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Aliases for B4GALT4 Gene

Aliases for B4GALT4 Gene

  • Beta-1,4-Galactosyltransferase 4 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 4 2 3 5
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 4 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 4 3 4
  • Beta-1,4-GalTase 4 3 4
  • Beta4Gal-T4 3 4
  • B4Gal-T4 3 4
  • Beta-N-Acetylglucosaminyl-Glycolipid Beta-1,4-Galactosyltransferase 4 3
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase 4 3
  • EC 2.4.1.- 4

External Ids for B4GALT4 Gene

Previous GeneCards Identifiers for B4GALT4 Gene

  • GC03M115619
  • GC03M118559
  • GC03M120211
  • GC03M120251
  • GC03M120413
  • GC03M118930
  • GC03M116306

Summaries for B4GALT4 Gene

Entrez Gene Summary for B4GALT4 Gene

  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for B4GALT4 Gene

B4GALT4 (Beta-1,4-Galactosyltransferase 4) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Keratan sulfate/keratin metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetyllactosamine synthase activity. An important paralog of this gene is B4GALT7.

UniProtKB/Swiss-Prot for B4GALT4 Gene

  • Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Wiki entry for B4GALT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALT4 Gene

Genomics for B4GALT4 Gene

Regulatory Elements for B4GALT4 Gene

Enhancers for B4GALT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B4GALT4 on UCSC Golden Path with GeneCards custom track

Promoters for B4GALT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B4GALT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for B4GALT4 Gene

Chromosome:
3
Start:
119,211,732 bp from pter
End:
119,241,103 bp from pter
Size:
29,372 bases
Orientation:
Minus strand

Genomic View for B4GALT4 Gene

Genes around B4GALT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALT4 Gene

Proteins for B4GALT4 Gene

  • Protein details for B4GALT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60513-B4GT4_HUMAN
    Recommended name:
    Beta-1,4-galactosyltransferase 4
    Protein Accession:
    O60513
    Secondary Accessions:
    • Q68D68
    • Q9BSW3
    • Q9C078

    Protein attributes for B4GALT4 Gene

    Size:
    344 amino acids
    Molecular mass:
    40041 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for B4GALT4 Gene

Proteomics data for B4GALT4 Gene at MOPED

Post-translational modifications for B4GALT4 Gene

  • Glycosylation at Asn 220 and Asn 335
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for B4GALT4 Gene

Domains & Families for B4GALT4 Gene

Gene Families for B4GALT4 Gene

Graphical View of Domain Structure for InterPro Entry

O60513

UniProtKB/Swiss-Prot:

B4GT4_HUMAN :
  • Belongs to the glycosyltransferase 7 family.
Family:
  • Belongs to the glycosyltransferase 7 family.
genes like me logo Genes that share domains with B4GALT4: view

Function for B4GALT4 Gene

Molecular function for B4GALT4 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=238 uM for GlcNAc-B-S-pNP {ECO:0000269 PubMed:11588157};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Enzyme Numbers (IUBMB) for B4GALT4 Gene

Gene Ontology (GO) - Molecular Function for B4GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B4GALT4: view
genes like me logo Genes that share phenotypes with B4GALT4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for B4GALT4

miRNA for B4GALT4 Gene

miRTarBase miRNAs that target B4GALT4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B4GALT4 Gene

Localization for B4GALT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B4GALT4 Gene COMPARTMENTS Subcellular localization image for B4GALT4 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for B4GALT4 Gene

Pathways & Interactions for B4GALT4 Gene

genes like me logo Genes that share pathways with B4GALT4: view

UniProtKB/Swiss-Prot O60513-B4GT4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B4GALT4 Gene

Gene Ontology (GO) - Biological Process for B4GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006643 membrane lipid metabolic process TAS 9792633
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with B4GALT4: view

No data available for SIGNOR curated interactions for B4GALT4 Gene

Drugs & Compounds for B4GALT4 Gene

(4) Drugs for B4GALT4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra Target 0
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
Manganese Pharma 32

(1) Additional Compounds for B4GALT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
32181-59-2
genes like me logo Genes that share compounds with B4GALT4: view

Transcripts for B4GALT4 Gene

Unigene Clusters for B4GALT4 Gene

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11a · 11b · 11c ^
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: -
SP9: - -
SP10:
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - -
SP17: - - - - - - - - - - - -

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for B4GALT4 Gene

GeneLoc Exon Structure for
B4GALT4
ECgene alternative splicing isoforms for
B4GALT4

Expression for B4GALT4 Gene

mRNA expression in normal human tissues for B4GALT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for B4GALT4 Gene

This gene is overexpressed in Islet of Langerhans (31.4), Placenta (17.4), and Platelet (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for B4GALT4 Gene



SOURCE GeneReport for Unigene cluster for B4GALT4 Gene Hs.13225

mRNA Expression by UniProt/SwissProt for B4GALT4 Gene

O60513-B4GT4_HUMAN
Tissue specificity: High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus.
genes like me logo Genes that share expression patterns with B4GALT4: view

Protein tissue co-expression partners for B4GALT4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for B4GALT4 Gene

Orthologs for B4GALT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B4GALT4 35
  • 86.35 (n)
  • 83.38 (a)
B4GALT4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B4GALT4 35
  • 87.79 (n)
  • 86.05 (a)
B4GALT4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galt4 35
  • 83.43 (n)
  • 83.43 (a)
B4galt4 16
B4galt4 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B4GALT4 35
  • 99.32 (n)
  • 97.97 (a)
B4GALT4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B4galt4 35
  • 83.04 (n)
  • 83.14 (a)
oppossum
(Monodelphis domestica)
Mammalia B4GALT4 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves B4GALT4 35
  • 70.26 (n)
  • 71.26 (a)
B4GALT4 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B4GALT4 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488464 35
  • 61.82 (n)
  • 60.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15219 35
zebrafish
(Danio rerio)
Actinopterygii b4galt4 35
  • 60.65 (n)
  • 61.39 (a)
b4galt4 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH13356 37
  • 42 (a)
CG14517 37
  • 39 (a)
beta4GalNAcTA 36
  • 28 (a)
ManyToMany
beta4GalNAcTB 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea W02B12.11 37
  • 36 (a)
Y73E7A.7 37
  • 44 (a)
bre-4 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.786 36
  • 31 (a)
OneToOne
Species with no ortholog for B4GALT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALT4 Gene

ENSEMBL:
Gene Tree for B4GALT4 (if available)
TreeFam:
Gene Tree for B4GALT4 (if available)

Paralogs for B4GALT4 Gene

Paralogs for B4GALT4 Gene

genes like me logo Genes that share paralogs with B4GALT4: view

Variants for B4GALT4 Gene

Sequence variations from dbSNP and Humsavar for B4GALT4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_022697 -
rs5868 -- 119,211,944(+) CAGCA(C/G/T)CTGCA utr-variant-3-prime
rs6774 -- 119,212,037(-) AAAGG(C/T)GACGA utr-variant-3-prime
rs1128038 -- 119,212,251(-) GACTC(C/T)GGTTG utr-variant-3-prime
rs4314161 -- 119,222,251(+) CAGAT(A/G)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALT4 Gene

Variant ID Type Subtype PubMed ID
esv25249 CNV Loss 19812545

Variation tolerance for B4GALT4 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 79.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for B4GALT4 Gene

Disorders for B4GALT4 Gene

Relevant External Links for B4GALT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B4GALT4

No disorders were found for B4GALT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B4GALT4 Gene

Publications for B4GALT4 Gene

  1. Cloning of a novel member of the UDP-galactose:beta-N- acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. (PMID: 9792633) Schwientek T. … Clausen H. (J. Biol. Chem. 1998) 2 3 4 67
  2. Chemoenzymatic synthesis of biotinylated nucleotide sugars as substrates for glycosyltransferases. (PMID: 11948877) BA1lter T. … Elling L. (Chembiochem 2001) 23 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PMID: 9597550) Lo N.-W. … Shaper N.L. (Glycobiology 1998) 2 3

Products for B4GALT4 Gene

Sources for B4GALT4 Gene

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