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Aliases for B4GALT4 Gene

Aliases for B4GALT4 Gene

  • Beta-1,4-Galactosyltransferase 4 2 3 5
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 4 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 4 2 3
  • UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 4 3 4
  • Beta-1,4-GalTase 4 3 4
  • Beta4Gal-T4 3 4
  • B4Gal-T4 3 4
  • Beta-N-Acetylglucosaminyl-Glycolipid Beta-1,4-Galactosyltransferase 4 3
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase 4 3
  • EC 2.4.1.- 4

External Ids for B4GALT4 Gene

Previous GeneCards Identifiers for B4GALT4 Gene

  • GC03M115619
  • GC03M118559
  • GC03M120211
  • GC03M120251
  • GC03M120413
  • GC03M118930
  • GC03M116306

Summaries for B4GALT4 Gene

Entrez Gene Summary for B4GALT4 Gene

  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for B4GALT4 Gene

B4GALT4 (Beta-1,4-Galactosyltransferase 4) is a Protein Coding gene. Among its related pathways are N-glycan antennae elongation in the medial/trans-Golgi and Keratan sulfate/keratin metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetyllactosamine synthase activity. An important paralog of this gene is B4GALT3.

UniProtKB/Swiss-Prot for B4GALT4 Gene

  • Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Wiki entry for B4GALT4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALT4 Gene

Genomics for B4GALT4 Gene

Regulatory Elements for B4GALT4 Gene

Enhancers for B4GALT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G119236 1.3 Ensembl ENCODE 11.9 +2.0 1956 5.2 HDGF FOXA2 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A YY1 ZNF143 ZNF263 B4GALT4 ARHGAP31 GSK3B GC03M119181
GH03G119348 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.2 -110.4 -110425 6.1 ATF1 TBL1XR1 ZSCAN4 RAD21 YY1 ETS1 GATA2 CBX5 RELB ETV6 ARHGAP31 ADPRH ARHGAP31-AS1 CD80 B4GALT4 IGSF11 RPL10P7 COX17 RNU6-1127P GC03M119342
GH03G119210 0.7 ENCODE 12.8 +29.7 29727 2.4 HDAC1 PKNOX1 TAL1 TCF12 NCOR1 ZBTB11 DPF2 ARID1B JUND HNF1A IGSF11 B4GALT4 UPK1B B4GALT4-AS1
GH03G120135 0.8 Ensembl ENCODE 10.4 -894.7 -894655 0.8 GTF3C2 JUND TEAD1 JUN CEBPB FOS EP300 POGLUT1 TMEM39A B4GALT4 GSK3B GPR156 PIR33291 RN7SL397P
GH03G119321 1.6 FANTOM5 ENCODE dbSUPER 4.6 -81.9 -81875 2.7 HDGF ARID4B SIN3A ZNF2 CBX5 ZNF143 ZNF207 FOS SP3 SP5 ARHGAP31 ADPRH B4GALT4 COX17 CD80 ARHGAP31-AS1 RNU6-1127P GC03M119342
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B4GALT4 on UCSC Golden Path with GeneCards custom track

Promoters for B4GALT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000305717 903 2001 HDGF ATF1 CREB3L1 AGO1 SIN3A YBX1 ZNF48 GLIS2 ZNF263 SP3

Genomic Location for B4GALT4 Gene

119,211,732 bp from pter
119,241,103 bp from pter
29,372 bases
Minus strand

Genomic View for B4GALT4 Gene

Genes around B4GALT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALT4 Gene

Proteins for B4GALT4 Gene

  • Protein details for B4GALT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-1,4-galactosyltransferase 4
    Protein Accession:
    Secondary Accessions:
    • Q68D68
    • Q9BSW3
    • Q9C078

    Protein attributes for B4GALT4 Gene

    344 amino acids
    Molecular mass:
    40041 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for B4GALT4 Gene

Post-translational modifications for B4GALT4 Gene

  • Glycosylation at posLast=220220 and posLast=335335
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for B4GALT4 Gene

Domains & Families for B4GALT4 Gene

Gene Families for B4GALT4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 7 family.
  • Belongs to the glycosyltransferase 7 family.
genes like me logo Genes that share domains with B4GALT4: view

Function for B4GALT4 Gene

Molecular function for B4GALT4 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=238 uM for GlcNAc-B-S-pNP {ECO:0000269 PubMed:11588157};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Enzyme Numbers (IUBMB) for B4GALT4 Gene

Gene Ontology (GO) - Molecular Function for B4GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity TAS --
GO:0003945 N-acetyllactosamine synthase activity IEA --
GO:0008378 galactosyltransferase activity TAS 9792633
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B4GALT4: view
genes like me logo Genes that share phenotypes with B4GALT4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for B4GALT4

miRNA for B4GALT4 Gene

miRTarBase miRNAs that target B4GALT4

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B4GALT4 Gene

Localization for B4GALT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B4GALT4 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for B4GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with B4GALT4: view

Pathways & Interactions for B4GALT4 Gene

genes like me logo Genes that share pathways with B4GALT4: view

UniProtKB/Swiss-Prot O60513-B4GT4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for B4GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006486 protein glycosylation IEA --
GO:0006643 membrane lipid metabolic process TAS 9792633
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with B4GALT4: view

No data available for SIGNOR curated interactions for B4GALT4 Gene

Drugs & Compounds for B4GALT4 Gene

(4) Drugs for B4GALT4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra Target 0
Manganese Approved Nutra 34
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(1) Additional Compounds for B4GALT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
genes like me logo Genes that share compounds with B4GALT4: view

Transcripts for B4GALT4 Gene

Unigene Clusters for B4GALT4 Gene

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11a · 11b · 11c ^
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: -
SP9: - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - -
SP17: - - - - - - - - - - - -

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - -
SP2: - -
SP3: -

Relevant External Links for B4GALT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B4GALT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B4GALT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for B4GALT4 Gene

This gene is overexpressed in Islet of Langerhans (31.4), Placenta (17.4), and Platelet (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for B4GALT4 Gene

Protein tissue co-expression partners for B4GALT4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of B4GALT4 Gene:


SOURCE GeneReport for Unigene cluster for B4GALT4 Gene:


mRNA Expression by UniProt/SwissProt for B4GALT4 Gene:

Tissue specificity: High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus.

Evidence on tissue expression from TISSUES for B4GALT4 Gene

  • Intestine(4.3)
  • Nervous system(4.3)
  • Muscle(4.2)
  • Kidney(3.1)
genes like me logo Genes that share expression patterns with B4GALT4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for B4GALT4 Gene

Orthologs for B4GALT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia B4GALT4 34 35
  • 99.32 (n)
(Canis familiaris)
Mammalia B4GALT4 34 35
  • 87.79 (n)
(Bos Taurus)
Mammalia B4GALT4 34 35
  • 86.35 (n)
(Mus musculus)
Mammalia B4galt4 34 16 35
  • 83.43 (n)
(Rattus norvegicus)
Mammalia B4galt4 34
  • 83.04 (n)
(Monodelphis domestica)
Mammalia B4GALT4 35
  • 74 (a)
(Gallus gallus)
Aves B4GALT4 34 35
  • 70.26 (n)
(Anolis carolinensis)
Reptilia B4GALT4 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488464 34
  • 61.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15219 34
(Danio rerio)
Actinopterygii b4galt4 34 35
  • 60.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH13356 36
  • 42 (a)
CG14517 36
  • 39 (a)
beta4GalNAcTB 35
  • 32 (a)
beta4GalNAcTA 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y73E7A.7 36
  • 44 (a)
W02B12.11 36
  • 36 (a)
bre-4 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.786 35
  • 31 (a)
Species where no ortholog for B4GALT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALT4 Gene

Gene Tree for B4GALT4 (if available)
Gene Tree for B4GALT4 (if available)

Paralogs for B4GALT4 Gene

Paralogs for B4GALT4 Gene

genes like me logo Genes that share paralogs with B4GALT4: view

Variants for B4GALT4 Gene

Sequence variations from dbSNP and Humsavar for B4GALT4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000132640 -- 119,240,643(+) GTGCC(C/T)CCCGC intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000268480 -- 119,225,674(+) TCCAC(C/T)CACCT intron-variant, upstream-variant-2KB
rs1000336401 -- 119,232,093(+) TTGAA(G/T)GAAAC intron-variant
rs1000436768 -- 119,238,841(+) TACAT(A/G)AGTTT intron-variant
rs1000731267 -- 119,227,752(+) TTCCA(C/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALT4 Gene

Variant ID Type Subtype PubMed ID
esv25249 CNV loss 19812545
esv3386832 CNV duplication 20981092
esv3597553 CNV loss 21293372
esv3597554 CNV loss 21293372
nsv591362 CNV loss 21841781

Variation tolerance for B4GALT4 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 79.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B4GALT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALT4 Gene

Disorders for B4GALT4 Gene

Relevant External Links for B4GALT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for B4GALT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B4GALT4 Gene

Publications for B4GALT4 Gene

  1. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PMID: 9597550) Lo N.-W. … Shaper N.L. (Glycobiology 1998) 2 3 4 64
  2. Cloning of a novel member of the UDP-galactose:beta-N- acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. (PMID: 9792633) Schwientek T. … Clausen H. (J. Biol. Chem. 1998) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Galactosylation of N-linked oligosaccharides by human beta-1,4- galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells. (PMID: 11588157) Guo S. … Furukawa K. (Glycobiology 2001) 3 4 64

Products for B4GALT4 Gene

Sources for B4GALT4 Gene

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