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Aliases & Descriptions for B4GALT3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Beta4Gal-T3 3 | | EC 2.4.1.- 3 | | OTTHUMP00000032247 2 | | OTTHUMP00000032248 2 | | b4Gal-T3 3 | | beta4Gal-T3 1, 2 |
| | | Descriptions |
|---|
| Beta-1,4-GalTase 3 3 | | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3 3 | | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 3 2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2 | UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3 3 | beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 3 2 |
|
| | Search outside databases for aliases for B4GALT3 genePrevious GC identifers: GC01M158852 GC01M156873 GC01M157918 GC01M158357 GC01M157954 |
Summaries for B4GALT3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B4GALT3: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. [provided by RefSeq] UniProtKB/Swiss-Prot: B4GT3_HUMAN, O60512Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipidsGene Wiki entry for B4GALT3 |
Genomic Location for B4GALT3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B4GALT3 gene 
Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q21-q23B4GALT3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M159407:
(about GC identifiers)
Start:
|
159,407,725 bp from pter |
End:
|
159,413,938 bp from pter |
Size:
|
6,214 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for B4GALT3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B4GT3_HUMAN, O60512 (See
protein sequence)Recommended Name: Beta-1,4-galactosyltransferase 3 Size: 393 amino acids; 43928 Da
Cofactor: Manganese (By similarity)
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack
Secondary accessions: O60910 Q9BPZ4 Q9H8T2Alternative splicing: 2 isoforms: O60512-1 O60512-2 REFSEQ proteins: NP_003770.1
ENSEMBL proteins: ENSP00000320965 ENSP00000385694 ENSP00000356977 ENSP00000356976 ENSP00000308551
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B4GALT3: Assays for B4GALT3: | Protein
Domains/ Families for B4GALT3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O60512
ProtoNet protein and cluster: O60512 1 Blocks protein family: IPB003859 Metazoa galactosyltransferase
UniProtKB/Swiss-Prot: B4GT3_HUMAN, O60512Similarity: Belongs to the glycosyltransferase 7 family | Gene Function for B4GALT3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003779
Applied Biosystems Silencer® siRNAs for B4GALT3
Sigma-Aldrich siRNA for B4GALT3  Sigma-Aldrich shRNA for B4GALT3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003779                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003779                                  untagged cDNA clone in CMV expression vector: NM_003779 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003779
UniProtKB/Swiss-Prot: B4GT3_HUMAN, O60512Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipidsCatalytic activity: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptideCatalytic activity: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamineBiophysicochemical properties: Kinetic parameters: KM=63 uM for GlcNAc-B-S-pNP;Enzyme Number (IUBMB): EC 2.4.1.- Genatlas biochemistry entry for B4GALT3:UDP galactose5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity |
IEA | -- | | GO:0003945 | N-acetyllactosamine synthase activity |
IEA | -- | | GO:0008378 | galactosyltransferase activity |
TAS | 9405390 | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | | GO:0030145 | manganese ion binding |
IEA | -- | About this table | Pathways & Interactions for B4GALT3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for B4GALT3 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: B4GT3_HUMAN, O60512Pathway: Protein modification; protein glycosylation 5/24 Interacting proteins for B4GALT3 (ENSP000003569773 O605122) via UniProtKB, MINT, and/or STRING (see all 24
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for B4GALT3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B4GALT3
|
Transcripts for B4GALT3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003779
Sigma-Aldrich siRNA for B4GALT3  Sigma-Aldrich shRNA for B4GALT3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003779 REFSEQ mRNAs for B4GALT3 gene: NM_003779.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003779               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003779                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003779                                  untagged cDNA clone in CMV expression vector: NM_003779  Additional cDNA sequence: AB024435.1 AF020921.1 AF038661.1 AK023311.1 AK056851.1 AK092493.1 AK094384.1 AK291455.1 BC000276.1 BC006099.1 BC009985.2 CR592876.1 CR599499.1 CR605946.1 CR607487.1 CR612341.1 CR614082.1 Y12509.1 24/28 DOTS entries (see all 28
): DT.100844432 DT.100820316 DT.447372 DT.95367558 DT.95367553 DT.95367546 DT.121391037 DT.99929812 DT.100820308 DT.100820304 DT.100820317 DT.121390996 DT.100820309 DT.91964187 DT.121390989 DT.121391036 DT.121390999 DT.100820306 DT.100820312 DT.121391039 DT.95367547 DT.100820307 DT.121390946 DT.121391019 24/389 AceView cDNA sequences (see all 389
):BQ918131 CB529148 AA887138 BF448185 BE793405 BM922744 AA479088 BM683525 AA704450 CR612341 BQ007000 AI582906 BM827492 BX279904 AK056851 BQ270935 BC009985 BM471281 AI298086 AA721091 AW770538 BQ942399 CR614082 BI768269
highest scoring ESTs for B4GALT3:AF038661 AA219689 AA219716 AA234701 AA411386 AA434286 AF020921 AL538395 AL558425 AL602940 Unigene Cluster for B4GALT3: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 Hs.321231 [show with all ESTs]Unigene Representative Sequence: AK056851
GeneLoc Exon Structure
5/22 Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT3 (see all 22
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | |
| SP1: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 13c | · | 13d | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for B4GALT3
5 Ensembl transcripts including schematic representations: ENST00000319769
ENST00000407555
ENST00000367998
ENST00000367997
ENST00000310413
|
Expression for B4GALT3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B4GALT3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B4GALT3
1 / 2 / 3 3 probe-sets matching B4GALT3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGAGAAGAG
SOURCE GeneReport for Unigene cluster: Hs.321231
Expression variation in blood from EXPOLDB for B4GALT3 UniProtKB/Swiss-Prot: B4GT3_HUMAN, O60512Tissue specificity: Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain |
Orthologs for B4GALT3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B4GALT3 gene from 5/9 species (see all 9
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
B4GALT31 |
-- |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more |
92.62(n) 98.22(a) |
488650 XM_545767.2 XP_545767.2 |
chimpanzee (Pan troglodytes) |
B4GALT31 |
-- |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more |
99.41(n) 99.75(a) |
457451 XM_001173446.1 XP_001173446.1 |
cow (Bos taurus) |
B4GALT31 |
-- |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more |
91.01(n) 95.93(a) |
515771 NM_001015609.1 NP_001015609.1 |
rat (Rattus norvegicus) |
B4galt31 |
-- |
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, more |
89.65(n) 96.69(a) |
494342 NM_001009539.1 NP_001009539.1 |
mouse (Mus musculus) |
B4galt31, 5 |
1 (92.60 cM)5
|
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, more1, 5 |
88.63(n)1 96.95(a)1 |
573701 NM_020579.11 NP_065604.11 AA1045625 AF1426715 (see all 17) |
About this table Species with no ortholog for B4GALT3
ENSEMBL Gene Tree for B4GALT3 | Paralogs for B4GALT3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B4GALT3 gene
- B4GALT22 B4GALT12 B4GALT42
|
SNPs/Variants for B4GALT3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B4GALT3 (up to first 250kb)
|
Disorders & Mutations for B4GALT3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604014
|
Medical News for B4GALT3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B4GALT3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for B4GALT3 gene (see all 16
):- A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. (PubMed id 9405390)1, 2, 3, 4 Almeida R.... Clausen H. (1997)
- The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PubMed id 9597550)2, 3, 4 Lo N.W....Shaper N.L. (1998)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Galactosylation of N-linked oligosaccharides by human beta-1,4- galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells. (PubMed id 11588157)3, 4 Guo S.... Furukawa K. (2001)
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)3, 4 Amado M.... Clausen H. (1999)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3. (PubMed id 17613536)3 Davidsson J....Johansson B. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
|
Search for B4GALT3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B4GALT3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B4GALT3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B4GALT3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_438 |
|
| | | About This Section
| --
| Services for B4GALT3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for B4GALT3:

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Incremental update: 13 Oct 2009
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