Aliases for B4GALT2 Gene
External Ids for B4GALT2 Gene
Previous GeneCards Identifiers for B4GALT2 Gene
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for B4GALT2 Gene
B4GALT2 (Beta-1,4-Galactosyltransferase 2) is a Protein Coding gene. Among its related pathways are Mannose type O-glycan biosynthesis and N-glycan antennae elongation in the medial/trans-Golgi. GO annotations related to this gene include galactosyltransferase activity and N-acetyllactosamine synthase activity. An important paralog of this gene is B4GALT1.
UniProtKB/Swiss-Prot for B4GALT2 Gene
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.