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Aliases for B4GALT2 Gene

Aliases for B4GALT2 Gene

  • Beta-1,4-Galactosyltransferase 2 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 2 2 3 5
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 2 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 2 3 4
  • Beta-1,4-GalTase 2 3 4
  • Beta4Gal-T2 3 4
  • B4Gal-T2 3 4
  • Beta-N-Acetylglucosaminyl-Glycolipid Beta-1,4-Galactosyltransferase 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,4-Galactosyltransferase, Polypeptide 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase 2 3
  • Beta-4-GalT2 3
  • EC 2.4.1.- 4
  • B4Gal-T3 3

External Ids for B4GALT2 Gene

Previous GeneCards Identifiers for B4GALT2 Gene

  • GC01P044283
  • GC01P043445
  • GC01P043875
  • GC01P043858
  • GC01P044114
  • GC01P044217
  • GC01P044444
  • GC01P042560

Summaries for B4GALT2 Gene

Entrez Gene Summary for B4GALT2 Gene

  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for B4GALT2 Gene

B4GALT2 (Beta-1,4-Galactosyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include galactosyltransferase activity and N-acetyllactosamine synthase activity. An important paralog of this gene is B4GALT7.

UniProtKB/Swiss-Prot for B4GALT2 Gene

  • Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.

Gene Wiki entry for B4GALT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALT2 Gene

Genomics for B4GALT2 Gene

Regulatory Elements for B4GALT2 Gene

Promoters for B4GALT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B4GALT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for B4GALT2 Gene

Chromosome:
1
Start:
43,978,943 bp from pter
End:
43,991,171 bp from pter
Size:
12,229 bases
Orientation:
Plus strand

Genomic View for B4GALT2 Gene

Genes around B4GALT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALT2 Gene

Proteins for B4GALT2 Gene

  • Protein details for B4GALT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60909-B4GT2_HUMAN
    Recommended name:
    Beta-1,4-galactosyltransferase 2
    Protein Accession:
    O60909
    Secondary Accessions:
    • B3KTP0
    • B4DE14
    • D3DPY6
    • D3DPY7
    • O60511
    • Q4V9L9
    • Q5T4X5
    • Q5T4Y5
    • Q9BUP6
    • Q9NSY7

    Protein attributes for B4GALT2 Gene

    Size:
    372 amino acids
    Molecular mass:
    41972 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for B4GALT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for B4GALT2 Gene

Proteomics data for B4GALT2 Gene at MOPED

Post-translational modifications for B4GALT2 Gene

  • Glycosylation at Asn 66, Asn 71, and Asn 357
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALT2 Gene

No data available for DME Specific Peptides for B4GALT2 Gene

Domains & Families for B4GALT2 Gene

Gene Families for B4GALT2 Gene

Suggested Antigen Peptide Sequences for B4GALT2 Gene

Graphical View of Domain Structure for InterPro Entry

O60909

UniProtKB/Swiss-Prot:

B4GT2_HUMAN :
  • Belongs to the glycosyltransferase 7 family.
Family:
  • Belongs to the glycosyltransferase 7 family.
genes like me logo Genes that share domains with B4GALT2: view

Function for B4GALT2 Gene

Molecular function for B4GALT2 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=71 uM for GlcNAc-B-S-pNP {ECO:0000269 PubMed:11588157};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + D-glucose = UDP + lactose.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
UniProtKB/Swiss-Prot Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.

Enzyme Numbers (IUBMB) for B4GALT2 Gene

Gene Ontology (GO) - Molecular Function for B4GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004461 lactose synthase activity IEA --
genes like me logo Genes that share ontologies with B4GALT2: view
genes like me logo Genes that share phenotypes with B4GALT2: view

Animal Models for B4GALT2 Gene

MGI Knock Outs for B4GALT2:

Animal Model Products

miRNA for B4GALT2 Gene

miRTarBase miRNAs that target B4GALT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B4GALT2 Gene

Localization for B4GALT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALT2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B4GALT2 Gene COMPARTMENTS Subcellular localization image for B4GALT2 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for B4GALT2 Gene

Pathways & Interactions for B4GALT2 Gene

genes like me logo Genes that share pathways with B4GALT2: view

UniProtKB/Swiss-Prot O60909-B4GT2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B4GALT2 Gene

Gene Ontology (GO) - Biological Process for B4GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with B4GALT2: view

No data available for SIGNOR curated interactions for B4GALT2 Gene

Drugs & Compounds for B4GALT2 Gene

(5) Drugs for B4GALT2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra Target 0
lactose Experimental Pharma 0
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
Manganese Pharma 32

(3) Additional Compounds for B4GALT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-Lactose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucopyranose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucose
  • beta-Lactose
5965-66-2
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
32181-59-2
genes like me logo Genes that share compounds with B4GALT2: view

Transcripts for B4GALT2 Gene

Unigene Clusters for B4GALT2 Gene

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -

Relevant External Links for B4GALT2 Gene

GeneLoc Exon Structure for
B4GALT2
ECgene alternative splicing isoforms for
B4GALT2

Expression for B4GALT2 Gene

mRNA expression in normal human tissues for B4GALT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for B4GALT2 Gene

This gene is overexpressed in Pancreas (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for B4GALT2 Gene



SOURCE GeneReport for Unigene cluster for B4GALT2 Gene Hs.632403

mRNA Expression by UniProt/SwissProt for B4GALT2 Gene

O60909-B4GT2_HUMAN
Tissue specificity: Weakly expressed in various tissues. Highest expression in prostate, testis, ovary, intestine, muscle, and in fetal brain.
genes like me logo Genes that share expression patterns with B4GALT2: view

Protein tissue co-expression partners for B4GALT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for B4GALT2 Gene

Orthologs for B4GALT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B4GALT2 35
  • 91.24 (n)
  • 95.93 (a)
B4GALT2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B4GALT2 35
  • 92.04 (n)
  • 95.48 (a)
B4GALT2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galt2 35
  • 89.97 (n)
  • 92.68 (a)
B4galt2 16
B4galt2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B4GALT2 35
  • 99 (n)
  • 99.25 (a)
B4GALT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B4galt2 35
  • 89.25 (n)
  • 92.14 (a)
oppossum
(Monodelphis domestica)
Mammalia B4GALT2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B4GALT2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves B4GALT2 35
  • 75.27 (n)
  • 77.75 (a)
B4GALT2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B4GALT2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galt2 35
  • 69.43 (n)
  • 76.8 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100148828 35
  • 69.47 (n)
  • 71 (a)
b4galt2 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH13356 37
  • 39 (a)
CG14517 37
  • 38 (a)
beta4GalNAcTA 35
  • 50.06 (n)
  • 41.28 (a)
beta4GalNAcTA 36
  • 31 (a)
ManyToMany
beta4GalNAcTB 36
  • 30 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004781 35
  • 53.44 (n)
  • 46.95 (a)
worm
(Caenorhabditis elegans)
Secernentea W02B12.11 37
  • 34 (a)
Y73E7A.7 37
  • 43 (a)
bre-4 35
  • 47.77 (n)
  • 41.24 (a)
bre-4 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13709 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for B4GALT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALT2 Gene

ENSEMBL:
Gene Tree for B4GALT2 (if available)
TreeFam:
Gene Tree for B4GALT2 (if available)

Paralogs for B4GALT2 Gene

Paralogs for B4GALT2 Gene

(5) SIMAP similar genes for B4GALT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B4GALT2: view

Variants for B4GALT2 Gene

Sequence variations from dbSNP and Humsavar for B4GALT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1859728 - 43,981,741(+) GTGCA(C/G)AGGGA reference, missense
VAR_054021 -
rs730915 -- 43,988,215(+) GCTTA(A/G)AAAGG intron-variant
rs730916 -- 43,987,898(+) CTCTA(C/T)CTGGA intron-variant
rs882961 -- 43,981,412(+) CCCAG(G/T)GCCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for B4GALT2 Gene

Variant ID Type Subtype PubMed ID
nsv870606 CNV Loss 21882294
dgv217n71 CNV Loss 21882294
nsv732 CNV Insertion 18451855

Variation tolerance for B4GALT2 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B4GALT2 Gene

HapMap Linkage Disequilibrium report
B4GALT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALT2 Gene

Disorders for B4GALT2 Gene

Relevant External Links for B4GALT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B4GALT2

No disorders were found for B4GALT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B4GALT2 Gene

Publications for B4GALT2 Gene

  1. A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. (PMID: 9405390) Almeida R. … Clausen H. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PMID: 9597550) Lo N.-W. … Shaper N.L. (Glycobiology 1998) 2 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for B4GALT2 Gene

Sources for B4GALT2 Gene

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