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Aliases for B4GALNT4 Gene

Aliases for B4GALNT4 Gene

  • Beta-1,4-N-Acetyl-Galactosaminyltransferase 4 2 3
  • N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N- Acetylgalactosaminyltransferase 2 3
  • Beta-1,4-N-Acetyl-Galactosaminyl Transferase 4 3 5
  • Beta-1,4-N-Acetylgalactosaminyltransferase IV 3 4
  • Beta4GalNAc-T4 3 4
  • Beta4GalNAcT4 3 4
  • NGalNAc-T1 3 4
  • Beta1,4-N-Acetylgalactosaminyltransferases IV 3
  • EC 2.4.1.244 4
  • BetaGT4 3

External Ids for B4GALNT4 Gene

Previous GeneCards Identifiers for B4GALNT4 Gene

  • GC11P000360
  • GC11P000361
  • GC11P000362
  • GC11P000363
  • GC11P000364
  • GC11P000365
  • GC11P000366
  • GC11P000368
  • GC11P000189

Summaries for B4GALNT4 Gene

GeneCards Summary for B4GALNT4 Gene

B4GALNT4 (Beta-1,4-N-Acetyl-Galactosaminyltransferase 4) is a Protein Coding gene. GO annotations related to this gene include acetylgalactosaminyltransferase activity and N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT3.

UniProtKB/Swiss-Prot for B4GALNT4 Gene

  • Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALNT4 Gene

Genomics for B4GALNT4 Gene

Regulatory Elements for B4GALNT4 Gene

Promoters for B4GALNT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B4GALNT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for B4GALNT4 Gene

Chromosome:
11
Start:
369,779 bp from pter
End:
382,117 bp from pter
Size:
12,339 bases
Orientation:
Plus strand

Genomic View for B4GALNT4 Gene

Genes around B4GALNT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALNT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALNT4 Gene

Proteins for B4GALNT4 Gene

  • Protein details for B4GALNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KP1-B4GN4_HUMAN
    Recommended name:
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
    Protein Accession:
    Q76KP1
    Secondary Accessions:
    • Q96LV2

    Protein attributes for B4GALNT4 Gene

    Size:
    1039 amino acids
    Molecular mass:
    116513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for B4GALNT4 Gene

Proteomics data for B4GALNT4 Gene at MOPED

Post-translational modifications for B4GALNT4 Gene

  • Glycosylation at Asn 105
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALNT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B4GALNT4 Gene

Domains & Families for B4GALNT4 Gene

Gene Families for B4GALNT4 Gene

Protein Domains for B4GALNT4 Gene

Suggested Antigen Peptide Sequences for B4GALNT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KP1

UniProtKB/Swiss-Prot:

B4GN4_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with B4GALNT4: view

Function for B4GALNT4 Gene

Molecular function for B4GALNT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
UniProtKB/Swiss-Prot Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

Enzyme Numbers (IUBMB) for B4GALNT4 Gene

genes like me logo Genes that share phenotypes with B4GALNT4: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B4GALNT4 Gene

Localization for B4GALNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALNT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B4GALNT4 Gene COMPARTMENTS Subcellular localization image for B4GALNT4 gene
Compartment Confidence
golgi apparatus 4
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for B4GALNT4 Gene

Pathways & Interactions for B4GALNT4 Gene

SuperPathways for B4GALNT4 Gene

No Data Available

Interacting Proteins for B4GALNT4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328277%0d%0a9606.ENSP00000035307%0d%0a9606.ENSP00000243776%0d%0a
Selected Interacting proteins: ENSP00000328277 for B4GALNT4 Gene via STRING

Gene Ontology (GO) - Biological Process for B4GALNT4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for B4GALNT4 Gene

Drugs & Compounds for B4GALNT4 Gene

(1) Drugs for B4GALNT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(3) Additional Compounds for B4GALNT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine
  • 2-Acetamido-2-deoxy-a-D-allopyranose
  • 2-Acetamido-2-deoxy-a-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-D-allopyranose
  • 2-Acetamido-2-deoxy-alpha-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-delta-allopyranose
1811-31-0
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with B4GALNT4: view

Transcripts for B4GALNT4 Gene

Unigene Clusters for B4GALNT4 Gene

Beta-1,4-N-acetyl-galactosaminyl transferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALNT4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2:
SP3:

Relevant External Links for B4GALNT4 Gene

GeneLoc Exon Structure for
B4GALNT4
ECgene alternative splicing isoforms for
B4GALNT4

Expression for B4GALNT4 Gene

mRNA expression in normal human tissues for B4GALNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALNT4 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for B4GALNT4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B4GALNT4 Gene



SOURCE GeneReport for Unigene cluster for B4GALNT4 Gene Hs.148074

mRNA Expression by UniProt/SwissProt for B4GALNT4 Gene

Q76KP1-B4GN4_HUMAN
Tissue specificity: Highly expressed in ovary, adult and fetal brain. Also expressed in fetal kidney and lung.
genes like me logo Genes that share expression patterns with B4GALNT4: view

Protein tissue co-expression partners for B4GALNT4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for B4GALNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B4GALNT4 35
  • 97.74 (n)
  • 96.56 (a)
B4GALNT4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia B4GALNT4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B4GALNT4 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galnt4 36
  • 85 (a)
OneToOne
B4galnt4 16
B4galnt4 35
  • 81.34 (n)
  • 85.2 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia B4GALNT4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B4galnt4 35
  • 81.09 (n)
  • 85.58 (a)
chicken
(Gallus gallus)
Aves B4GALNT4 36
  • 63 (a)
OneToOne
B4GALNT4 35
  • 68.79 (n)
  • 66.26 (a)
lizard
(Anolis carolinensis)
Reptilia B4GALNT4 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2208 35
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galnt4 35
  • 67.08 (n)
  • 67.12 (a)
Str.8405 35
zebrafish
(Danio rerio)
Actinopterygii LOC559305 35
  • 66.19 (n)
  • 67.1 (a)
B4GALNT4 (2 of 2) 36
  • 48 (a)
OneToMany
b4galnt4a 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43313 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.937 36
  • 15 (a)
OneToMany
Species with no ortholog for B4GALNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALNT4 Gene

ENSEMBL:
Gene Tree for B4GALNT4 (if available)
TreeFam:
Gene Tree for B4GALNT4 (if available)

Paralogs for B4GALNT4 Gene

Paralogs for B4GALNT4 Gene

(1) SIMAP similar genes for B4GALNT4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with B4GALNT4: view

Variants for B4GALNT4 Gene

Sequence variations from dbSNP and Humsavar for B4GALNT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34063493 - 372,157(+) CGCTG(A/C/G/T)GCCAT reference, missense
rs11822725 - 372,669(+) CGAAG(G/T)TCGGG reference, missense
rs7480018 -- 381,041(-) TGGGC(A/G)CCGTG intron-variant
rs7395781 -- 373,427(-) CAGGG(A/G)TGGTG intron-variant
rs7396812 -- 373,404(-) GTTCA(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALNT4 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv896488 CNV Loss 21882294
nsv896491 CNV Loss 21882294
dgv923n71 CNV Loss 21882294
esv28392 CNV Gain+Loss 19812545
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv825676 CNV Gain 20364138
nsv469923 CNV Loss 18288195
esv990569 CNV Deletion 20482838
esv1612736 CNV Deletion 17803354

Variation tolerance for B4GALNT4 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B4GALNT4 Gene

HapMap Linkage Disequilibrium report
B4GALNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALNT4 Gene

Disorders for B4GALNT4 Gene

Relevant External Links for B4GALNT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B4GALNT4

No disorders were found for B4GALNT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B4GALNT4 Gene

Publications for B4GALNT4 Gene

  1. Molecular cloning and characterization of beta1,4-N- acetylgalactosaminyltransferases IV synthesizing N,N'- diacetyllactosediamine. (PMID: 15044014) Gotoh M. … Narimatsu H. (FEBS Lett. 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Enhanced expression of the I^4-N-acetylgalactosaminyltransferase 4A gene impairs tumor growth of human breast cancer cells. (PMID: 25858323) Hirano K. … Furukawa K. (Biochem. Biophys. Res. Commun. 2015) 3
  4. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases I^1,4-N-acetylgalactosaminyl transferase 3 (I^4GalNAc-T3) and I^4GalNAc-T4. (PMID: 22722937) Fiete D. … Baenziger J.U. (J. Biol. Chem. 2012) 3
  5. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases I^1,4-N-acetylgalactosaminyl transferase 3 (I^4GalNAc-T3) and I^4GalNAc-T4. (PMID: 22722940) Fiete D. … Baenziger J.U. (J. Biol. Chem. 2012) 3

Products for B4GALNT4 Gene

Sources for B4GALNT4 Gene

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