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Aliases for B4GALNT4 Gene

Aliases for B4GALNT4 Gene

  • Beta-1,4-N-Acetyl-Galactosaminyltransferase 4 2 3 5
  • N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N- Acetylgalactosaminyltransferase 2 3
  • Beta-1,4-N-Acetylgalactosaminyltransferase IV 3 4
  • Beta4GalNAc-T4 3 4
  • Beta4GalNAcT4 3 4
  • NGalNAc-T1 3 4
  • N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N-Acetylgalactosaminyltransferase 1 3
  • Beta-1,4-N-Acetyl-Galactosaminyl Transferase 4 3
  • Beta1,4-N-Acetylgalactosaminyltransferases IV 3
  • EC 2.4.1.244 4
  • BetaGT4 3

External Ids for B4GALNT4 Gene

Previous GeneCards Identifiers for B4GALNT4 Gene

  • GC11P000360
  • GC11P000361
  • GC11P000362
  • GC11P000363
  • GC11P000364
  • GC11P000365
  • GC11P000366
  • GC11P000368
  • GC11P000189

Summaries for B4GALNT4 Gene

GeneCards Summary for B4GALNT4 Gene

B4GALNT4 (Beta-1,4-N-Acetyl-Galactosaminyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism. GO annotations related to this gene include acetylgalactosaminyltransferase activity and N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT3.

UniProtKB/Swiss-Prot for B4GALNT4 Gene

  • Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALNT4 Gene

Genomics for B4GALNT4 Gene

Regulatory Elements for B4GALNT4 Gene

Enhancers for B4GALNT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G000839 1.4 ENCODE dbSUPER 13.3 +474.0 474002 7.6 HDGF FOXA2 PKNOX1 ARNT CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 CD151 RIC8A SNORA52 TSPAN4 PHRF1 RPLP2 B4GALNT4 ENSG00000255237 PIDD1 SLC25A22
GH11G000364 1.1 Ensembl ENCODE 12.2 -5.0 -5025 1.4 ELF3 HDGF ARID4B ZNF48 RAD21 ZNF143 FOS MIXL1 THAP11 SP5 B4GALNT4 ENSG00000270972
GH11G000352 1.8 FANTOM5 Ensembl ENCODE 7.1 -15.2 -15193 4.7 HNRNPUL1 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B DMAP1 YBX1 IFITM1 ENSG00000254910 ENSG00000251661 PHRF1 PGGHG SNORA52 IFITM3 LOC105376505 ENSG00000255089 ENSG00000255237
GH11G000370 0.7 ENCODE 8.2 +0.6 609 1.6 ATF1 ZBTB21 ARID4B RBBP5 GLIS2 POLR2A EZH2 MAZ PHF8 CHD1 B4GALNT4 SIGIRR ENSG00000254815 GC11P000389
GH11G000824 1.3 ENCODE dbSUPER 4.2 +457.5 457522 6.4 HDGF PKNOX1 CREB3L1 AGO1 SIN3A ARID4B DMAP1 ZNF143 ZNF207 KLF13 CD151 RPLP2 PHRF1 SNORA52 ENSG00000255237 RIC8A TSPAN4 CRACR2B LOC171391 CHID1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B4GALNT4 on UCSC Golden Path with GeneCards custom track

Promoters for B4GALNT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035613 -179 1201 KLF1 ATF1 ZBTB21 ARID4B RBBP5 ZNF335 GLIS2 POLR2A PATZ1 KDM5B

Genomic Location for B4GALNT4 Gene

Chromosome:
11
Start:
369,779 bp from pter
End:
382,117 bp from pter
Size:
12,339 bases
Orientation:
Plus strand

Genomic View for B4GALNT4 Gene

Genes around B4GALNT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALNT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALNT4 Gene

Proteins for B4GALNT4 Gene

  • Protein details for B4GALNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KP1-B4GN4_HUMAN
    Recommended name:
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
    Protein Accession:
    Q76KP1
    Secondary Accessions:
    • Q96LV2

    Protein attributes for B4GALNT4 Gene

    Size:
    1039 amino acids
    Molecular mass:
    116513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for B4GALNT4 Gene

Post-translational modifications for B4GALNT4 Gene

  • Glycosylation at Asn105
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALNT4 Gene

No data available for DME Specific Peptides for B4GALNT4 Gene

Domains & Families for B4GALNT4 Gene

Gene Families for B4GALNT4 Gene

Protein Domains for B4GALNT4 Gene

Suggested Antigen Peptide Sequences for B4GALNT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KP1

UniProtKB/Swiss-Prot:

B4GN4_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with B4GALNT4: view

Function for B4GALNT4 Gene

Molecular function for B4GALNT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
UniProtKB/Swiss-Prot Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

Enzyme Numbers (IUBMB) for B4GALNT4 Gene

Gene Ontology (GO) - Molecular Function for B4GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IDA 15044014
GO:0016740 transferase activity IEA --
GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with B4GALNT4: view
genes like me logo Genes that share phenotypes with B4GALNT4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B4GALNT4 Gene

Localization for B4GALNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALNT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B4GALNT4 gene
Compartment Confidence
golgi apparatus 4
cytoskeleton 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for B4GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with B4GALNT4: view

Pathways & Interactions for B4GALNT4 Gene

SuperPathways for B4GALNT4 Gene

SuperPathway Contained pathways
1 Metabolism
genes like me logo Genes that share pathways with B4GALNT4: view

Pathways by source for B4GALNT4 Gene

1 KEGG pathway for B4GALNT4 Gene

Interacting Proteins for B4GALNT4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328277%0d%0a9606.ENSP00000198536%0d%0a9606.ENSP00000243776%0d%0a9606.ENSP00000035307%0d%0a
Selected Interacting proteins: ENSP00000328277 Q76KP1-B4GN4_HUMAN for B4GALNT4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for B4GALNT4 Gene

None

No data available for SIGNOR curated interactions for B4GALNT4 Gene

Drugs & Compounds for B4GALNT4 Gene

(1) Drugs for B4GALNT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(3) Additional Compounds for B4GALNT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine
  • 2-Acetamido-2-deoxy-a-D-allopyranose
  • 2-Acetamido-2-deoxy-a-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-D-allopyranose
  • 2-Acetamido-2-deoxy-alpha-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-delta-allopyranose
1811-31-0
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with B4GALNT4: view

Transcripts for B4GALNT4 Gene

Unigene Clusters for B4GALNT4 Gene

Beta-1,4-N-acetyl-galactosaminyl transferase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALNT4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2:
SP3:

Relevant External Links for B4GALNT4 Gene

GeneLoc Exon Structure for
B4GALNT4
ECgene alternative splicing isoforms for
B4GALNT4

Expression for B4GALNT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B4GALNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALNT4 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for B4GALNT4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B4GALNT4 Gene



Protein tissue co-expression partners for B4GALNT4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of B4GALNT4 Gene:

B4GALNT4

SOURCE GeneReport for Unigene cluster for B4GALNT4 Gene:

Hs.148074

mRNA Expression by UniProt/SwissProt for B4GALNT4 Gene:

Q76KP1-B4GN4_HUMAN
Tissue specificity: Highly expressed in ovary, adult and fetal brain. Also expressed in fetal kidney and lung.

Evidence on tissue expression from TISSUES for B4GALNT4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with B4GALNT4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for B4GALNT4 Gene

Orthologs for B4GALNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B4GALNT4 34 35
  • 97.74 (n)
cow
(Bos Taurus)
Mammalia B4GALNT4 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galnt4 34 16 35
  • 81.34 (n)
rat
(Rattus norvegicus)
Mammalia B4galnt4 34
  • 81.09 (n)
dog
(Canis familiaris)
Mammalia B4GALNT4 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B4GALNT4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves B4GALNT4 34 35
  • 68.79 (n)
lizard
(Anolis carolinensis)
Reptilia B4GALNT4 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galnt4 34
  • 67.08 (n)
Str.8405 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2208 34
zebrafish
(Danio rerio)
Actinopterygii LOC559305 34
  • 66.19 (n)
b4galnt4a 35
  • 50 (a)
OneToMany
B4GALNT4 (2 of 2) 35
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43313 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.937 35
  • 15 (a)
OneToMany
Species where no ortholog for B4GALNT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALNT4 Gene

ENSEMBL:
Gene Tree for B4GALNT4 (if available)
TreeFam:
Gene Tree for B4GALNT4 (if available)

Paralogs for B4GALNT4 Gene

Paralogs for B4GALNT4 Gene

(1) SIMAP similar genes for B4GALNT4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with B4GALNT4: view

Variants for B4GALNT4 Gene

Sequence variations from dbSNP and Humsavar for B4GALNT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000273459 -- 376,375(+) CCTGG(C/T)CCGCA intron-variant
rs1000429010 -- 380,122(+) TCGCC(C/G)TCCCC intron-variant, nc-transcript-variant
rs1000436225 -- 371,929(+) TGCTG(A/G/T)GGGGA intron-variant
rs1000819402 -- 381,836(+) GGCAG(C/G)TGCTG nc-transcript-variant, utr-variant-3-prime
rs1000891739 -- 372,214(+) AGCGG(A/T)GAGCA splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALNT4 Gene

Variant ID Type Subtype PubMed ID
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
dgv1507n54 CNV loss 21841781
dgv182e199 CNV deletion 23128226
esv1612736 CNV deletion 17803354
esv28392 CNV gain+loss 19812545
esv3445362 CNV duplication 20981092
esv990569 CNV deletion 20482838
nsv1069534 CNV deletion 25765185
nsv1069535 CNV deletion 25765185
nsv1118197 CNV deletion 24896259
nsv1126279 CNV deletion 24896259
nsv1159790 CNV deletion 26073780
nsv467633 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv552770 CNV gain 21841781
nsv552776 CNV loss 21841781
nsv825676 CNV gain 20364138
nsv951268 CNV deletion 24416366

Variation tolerance for B4GALNT4 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B4GALNT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
B4GALNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALNT4 Gene

Disorders for B4GALNT4 Gene

Relevant External Links for B4GALNT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B4GALNT4

No disorders were found for B4GALNT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B4GALNT4 Gene

Publications for B4GALNT4 Gene

  1. Molecular cloning and characterization of beta1,4-N- acetylgalactosaminyltransferases IV synthesizing N,N'- diacetyllactosediamine. (PMID: 15044014) Gotoh M. … Narimatsu H. (FEBS Lett. 2004) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Enhanced expression of the I^4-N-acetylgalactosaminyltransferase 4A gene impairs tumor growth of human breast cancer cells. (PMID: 25858323) Hirano K. … Furukawa K. (Biochem. Biophys. Res. Commun. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases I^1,4-N-acetylgalactosaminyl transferase 3 (I^4GalNAc-T3) and I^4GalNAc-T4. (PMID: 22722937) Fiete D. … Baenziger J.U. (J. Biol. Chem. 2012) 3 64

Products for B4GALNT4 Gene

Sources for B4GALNT4 Gene

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