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Aliases for B4GALNT4 Gene

Aliases for B4GALNT4 Gene

  • Beta-1,4-N-Acetyl-Galactosaminyl Transferase 4 2 3
  • Beta-1,4-N-Acetylgalactosaminyltransferase IV 3 4
  • Beta4GalNAc-T4 3 4
  • Beta4GalNAcT4 3 4
  • NGalNAc-T1 3 4
  • N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N-Acetylgalactosaminyltransferase 1 3
  • Beta1,4-N-Acetylgalactosaminyltransferases IV 3
  • EC 2.4.1.244 4
  • BetaGT4 3

External Ids for B4GALNT4 Gene

Previous GeneCards Identifiers for B4GALNT4 Gene

  • GC11P000360
  • GC11P000361
  • GC11P000362
  • GC11P000363
  • GC11P000364
  • GC11P000365
  • GC11P000366
  • GC11P000368
  • GC11P000189

Summaries for B4GALNT4 Gene

GeneCards Summary for B4GALNT4 Gene

B4GALNT4 (Beta-1,4-N-Acetyl-Galactosaminyl Transferase 4) is a Protein Coding gene. GO annotations related to this gene include acetylgalactosaminyltransferase activity and N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT3.

UniProtKB/Swiss-Prot for B4GALNT4 Gene

  • Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALNT4 Gene

Genomics for B4GALNT4 Gene

Regulatory Elements for B4GALNT4 Gene

Genomic Location for B4GALNT4 Gene

Start:
369,795 bp from pter
End:
382,117 bp from pter
Size:
12,323 bases
Orientation:
Plus strand

Genomic View for B4GALNT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B4GALNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALNT4 Gene

Proteins for B4GALNT4 Gene

  • Protein details for B4GALNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KP1-B4GN4_HUMAN
    Recommended name:
    N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
    Protein Accession:
    Q76KP1
    Secondary Accessions:
    • Q96LV2

    Protein attributes for B4GALNT4 Gene

    Size:
    1039 amino acids
    Molecular mass:
    116513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for B4GALNT4 Gene

Proteomics data for B4GALNT4 Gene at MOPED

Post-translational modifications for B4GALNT4 Gene

  • Glycosylation at Asn105
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALNT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B4GALNT4 Gene

Domains for B4GALNT4 Gene

Gene Families for B4GALNT4 Gene

HGNC:
  • B4GT :Beta 4-glycosyltransferases

Protein Domains for B4GALNT4 Gene

Suggested Antigen Peptide Sequences for B4GALNT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KP1

UniProtKB/Swiss-Prot:

B4GN4_HUMAN :
  • Q76KP1
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with B4GALNT4: view

Function for B4GALNT4 Gene

Molecular function for B4GALNT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
UniProtKB/Swiss-Prot Function: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans

Enzyme Numbers (IUBMB) for B4GALNT4 Gene

Gene Ontology (GO) - Molecular Function for B4GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IDA 15044014
GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with B4GALNT4: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for B4GALNT4 Gene

Localization for B4GALNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALNT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B4GALNT4 Gene COMPARTMENTS Subcellular localization image for B4GALNT4 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for B4GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with B4GALNT4: view

Pathways for B4GALNT4 Gene

SuperPathways for B4GALNT4 Gene

No Data Available

Interacting Proteins for B4GALNT4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328277%0d%0a9606.ENSP00000243776%0d%0a9606.ENSP00000035307%0d%0a
Selected Interacting proteins: ENSP00000328277 for B4GALNT4 Gene via STRING

Gene Ontology (GO) - Biological Process for B4GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with B4GALNT4: view

No data available for Pathways by source for B4GALNT4 Gene

Compounds for B4GALNT4 Gene

(2) HMDB Compounds for B4GALNT4 Gene

Compound Synonyms Cas Number PubMed IDs
N-Acetylgalactosamine
  • 2-Acetamido-2-desoxy-b-D-talofuranose
1811-31-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with B4GALNT4: view

Transcripts for B4GALNT4 Gene

Unigene Clusters for B4GALNT4 Gene

Beta-1,4-N-acetyl-galactosaminyl transferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALNT4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2:
SP3:

Relevant External Links for B4GALNT4 Gene

GeneLoc Exon Structure for
B4GALNT4
ECgene alternative splicing isoforms for
B4GALNT4

Expression for B4GALNT4 Gene

mRNA expression in normal human tissues for B4GALNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALNT4 Gene

This gene is overexpressed in Brain - Cerebellum (4.3) and Brain - Cortex (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for B4GALNT4 Gene

SOURCE GeneReport for Unigene cluster for B4GALNT4 Gene Hs.148074

mRNA Expression by UniProt/SwissProt for B4GALNT4 Gene

Q76KP1-B4GN4_HUMAN
Tissue specificity: Highly expressed in ovary, adult and fetal brain. Also expressed in fetal kidney and lung.
genes like me logo Genes that share expressions with B4GALNT4: view

Orthologs for B4GALNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B4GALNT4 35
  • 97.74 (n)
  • 96.56 (a)
B4GALNT4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia B4GALNT4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B4GALNT4 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galnt4 35
  • 81.34 (n)
  • 85.2 (a)
B4galnt4 16
B4galnt4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B4GALNT4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B4galnt4 35
  • 81.09 (n)
  • 85.58 (a)
chicken
(Gallus gallus)
Aves B4GALNT4 35
  • 68.79 (n)
  • 66.26 (a)
B4GALNT4 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B4GALNT4 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2208 35
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galnt4 35
  • 67.08 (n)
  • 67.12 (a)
Str.8405 35
zebrafish
(Danio rerio)
Actinopterygii B4GALNT4 (2 of 2) 36
  • 48 (a)
OneToMany
b4galnt4a 36
  • 50 (a)
OneToMany
LOC559305 35
  • 66.19 (n)
  • 67.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43313 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.937 36
  • 15 (a)
OneToMany
Species with no ortholog for B4GALNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALNT4 Gene

ENSEMBL:
Gene Tree for B4GALNT4 (if available)
TreeFam:
Gene Tree for B4GALNT4 (if available)

Paralogs for B4GALNT4 Gene

Paralogs for B4GALNT4 Gene

Selected SIMAP similar genes for B4GALNT4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with B4GALNT4: view

Variants for B4GALNT4 Gene

Sequence variations from dbSNP and Humsavar for B4GALNT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15649 -- 377,284(-) GGTCA(C/T)GTCCA missense, reference
rs1134699 -- 379,598(-) GCGGG(C/T)TCGGG reference, synonymous-codon
rs7120441 -- 371,047(-) GGTTT(C/T)GTTCT intron-variant
rs7129699 -- 377,773(-) GGAAC(A/G)CCCAG intron-variant
rs7395781 -- 373,427(-) CAGGG(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALNT4 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv896488 CNV Loss 21882294
nsv896491 CNV Loss 21882294
dgv923n71 CNV Loss 21882294
esv28392 CNV Gain+Loss 19812545
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv825676 CNV Gain 20364138
nsv469923 CNV Loss 18288195
esv990569 CNV Deletion 20482838
esv1612736 CNV Deletion 17803354

Relevant External Links for B4GALNT4 Gene

HapMap Linkage Disequilibrium report
B4GALNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALNT4 Gene

Disorders for B4GALNT4 Gene

No disorders were found for B4GALNT4 Gene.

No data available for UniProtKB/Swiss-Prot for B4GALNT4 Gene

Publications for B4GALNT4 Gene

  1. Molecular cloning and characterization of beta1,4-N- acetylgalactosaminyltransferases IV synthesizing N,N'- diacetyllactosediamine. (PMID: 15044014) Gotoh M. … Narimatsu H. (FEBS Lett. 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. A necessary and sufficient determinant for protein-selective glycosylation in vivo. (PMID: 18048353) Miller E. … Baenziger J.U. (J. Biol. Chem. 2008) 3
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for B4GALNT4 Gene

Sources for B4GALNT4 Gene

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