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Aliases for B4GALNT3 Gene

Aliases for B4GALNT3 Gene

  • Beta-1,4-N-Acetyl-Galactosaminyltransferase 3 2 3
  • N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N-Acetylgalactosaminyltransferase 2 3 4
  • Beta-1,4-N-Acetylgalactosaminyltransferase III 3 4
  • Beta-1,4-N-Acetyl-Galactosaminyl Transferase 3 3 5
  • Beta4GalNAc-T3 3 4
  • Beta4GalNAcT3 3 4
  • B4GalNAcT3 3 4
  • NGalNAc-T2 3 4
  • N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N- Acetylgalactosaminyltransferase 3
  • EC 4

External Ids for B4GALNT3 Gene

Previous GeneCards Identifiers for B4GALNT3 Gene

  • GC12P000440
  • GC12P000569

Summaries for B4GALNT3 Gene

Entrez Gene Summary for B4GALNT3 Gene

  • B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]

GeneCards Summary for B4GALNT3 Gene

B4GALNT3 (Beta-1,4-N-Acetyl-Galactosaminyltransferase 3) is a Protein Coding gene. GO annotations related to this gene include acetylgalactosaminyltransferase activity and N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for B4GALNT3 Gene

  • Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N-diacetyllactosediamine formation on gastric mucosa.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALNT3 Gene

Genomics for B4GALNT3 Gene

Regulatory Elements for B4GALNT3 Gene

Enhancers for B4GALNT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B4GALNT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for B4GALNT3 Gene

460,364 bp from pter
563,509 bp from pter
103,146 bases
Plus strand

Genomic View for B4GALNT3 Gene

Genes around B4GALNT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALNT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALNT3 Gene

Proteins for B4GALNT3 Gene

  • Protein details for B4GALNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-1,4-N-acetylgalactosaminyltransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q6ZNC1
    • Q8N7T6

    Protein attributes for B4GALNT3 Gene

    998 amino acids
    Molecular mass:
    114975 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18454.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305};

neXtProt entry for B4GALNT3 Gene

Proteomics data for B4GALNT3 Gene at MOPED

Post-translational modifications for B4GALNT3 Gene

  • Glycosylation at Ser 70
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALNT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B4GALNT3 Gene

Domains & Families for B4GALNT3 Gene

Gene Families for B4GALNT3 Gene

Protein Domains for B4GALNT3 Gene

Suggested Antigen Peptide Sequences for B4GALNT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with B4GALNT3: view

Function for B4GALNT3 Gene

Molecular function for B4GALNT3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
UniProtKB/Swiss-Prot Function:
Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N-diacetyllactosediamine formation on gastric mucosa.

Enzyme Numbers (IUBMB) for B4GALNT3 Gene

genes like me logo Genes that share phenotypes with B4GALNT3: view

Animal Models for B4GALNT3 Gene

MGI Knock Outs for B4GALNT3:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B4GALNT3 Gene

Localization for B4GALNT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALNT3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes to apical Golgi.

Subcellular locations from

Jensen Localization Image for B4GALNT3 Gene COMPARTMENTS Subcellular localization image for B4GALNT3 gene
Compartment Confidence
golgi apparatus 4
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for B4GALNT3 Gene

Pathways & Interactions for B4GALNT3 Gene

SuperPathways for B4GALNT3 Gene

No Data Available

Interacting Proteins for B4GALNT3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000266383 for B4GALNT3 Gene via STRING

Gene Ontology (GO) - Biological Process for B4GALNT3 Gene


No data available for Pathways by source and SIGNOR curated interactions for B4GALNT3 Gene

Drugs & Compounds for B4GALNT3 Gene

(2) Drugs for B4GALNT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0
Chondroitin Nutra 43

(3) Additional Compounds for B4GALNT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-Acetamido-2-deoxy-a-D-allopyranose
  • 2-Acetamido-2-deoxy-a-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-D-allopyranose
  • 2-Acetamido-2-deoxy-alpha-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-delta-allopyranose
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
genes like me logo Genes that share compounds with B4GALNT3: view

Transcripts for B4GALNT3 Gene

Unigene Clusters for B4GALNT3 Gene

Beta-1,4-N-acetyl-galactosaminyl transferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALNT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: -
SP4: -

Relevant External Links for B4GALNT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B4GALNT3 Gene

mRNA expression in normal human tissues for B4GALNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALNT3 Gene

This gene is overexpressed in Stomach (x7.6).

Protein differential expression in normal tissues from HIPED for B4GALNT3 Gene

This gene is overexpressed in Liver (47.2) and Bone (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B4GALNT3 Gene

SOURCE GeneReport for Unigene cluster for B4GALNT3 Gene Hs.504416

mRNA Expression by UniProt/SwissProt for B4GALNT3 Gene

Tissue specificity: Highly expressed in testis, colon and stomach. Weakly expressed in other tissues.
genes like me logo Genes that share expression patterns with B4GALNT3: view

Protein tissue co-expression partners for B4GALNT3 Gene

Primer Products

Orthologs for B4GALNT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALNT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia B4GALNT3 35
  • 83.71 (n)
  • 82.09 (a)
  • 79 (a)
(Canis familiaris)
Mammalia B4GALNT3 35
  • 88.16 (n)
  • 88.27 (a)
  • 88 (a)
(Mus musculus)
Mammalia B4galnt3 35
  • 84.1 (n)
  • 83.76 (a)
B4galnt3 16
B4galnt3 36
  • 84 (a)
(Pan troglodytes)
Mammalia B4GALNT3 35
  • 99.27 (n)
  • 99.2 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia B4galnt3 35
  • 83.2 (n)
  • 82.48 (a)
(Monodelphis domestica)
Mammalia B4GALNT3 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia B4GALNT3 36
  • 65 (a)
(Gallus gallus)
Aves B4GALNT3 35
  • 69.33 (n)
  • 67.93 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia B4GALNT3 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galnt3 35
  • 64.66 (n)
  • 61.44 (a)
Str.11923 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15475 35
(Danio rerio)
Actinopterygii b4galnt3b 35
  • 59.56 (n)
  • 55.9 (a)
B4GALNT3 (2 of 3) 36
  • 41 (a)
b4galnt3a 36
  • 40 (a)
b4galnt3b 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43313 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea mig-22 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.937 36
  • 15 (a)
Species with no ortholog for B4GALNT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALNT3 Gene

Gene Tree for B4GALNT3 (if available)
Gene Tree for B4GALNT3 (if available)

Paralogs for B4GALNT3 Gene

Paralogs for B4GALNT3 Gene

(1) SIMAP similar genes for B4GALNT3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with B4GALNT3: view

Variants for B4GALNT3 Gene

Sequence variations from dbSNP and Humsavar for B4GALNT3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2075033 - 535,171(+) GGTAC(A/G)GCAGC reference, missense
rs11063529 - 548,238(+) GCGAC(A/G)GAACG reference, missense
rs7298766 - 552,490(+) CATCA(A/G)GATTG reference, missense
rs11063570 - 556,789(+) TACCC(A/G)GGCCC reference, missense
rs36078145 - 561,429(-) GGCGA(C/T)GGCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for B4GALNT3 Gene

Variant ID Type Subtype PubMed ID
dgv452e1 CNV Complex 17122850
nsv898566 CNV Loss 21882294
dgv1337n71 CNV Gain 21882294
nsv898569 CNV Gain 21882294
nsv898570 CNV Gain 21882294
nsv468948 CNV Gain 19166990
nsv898571 CNV Gain 21882294
esv2745354 CNV Deletion 23290073
esv21735 CNV Loss 19812545
esv2210414 CNV Deletion 18987734
esv2745355 CNV Deletion 23290073
esv1142574 CNV Deletion 17803354
esv1129945 CNV Deletion 17803354
esv2745356 CNV Deletion 23290073
esv1270072 CNV Deletion 17803354
nsv468951 CNV Gain 19166990
nsv470254 CNV Gain 18288195
nsv8885 CNV Loss 18304495
nsv8886 CNV Loss 18304495
esv2745357 CNV Deletion 23290073
esv2745358 CNV Deletion 23290073
esv2745359 CNV Deletion 23290073
esv1181627 CNV Insertion 17803354
nsv8887 CNV Gain 18304495
nsv898572 CNV Gain 21882294
nsv519441 CNV Gain 19592680

Variation tolerance for B4GALNT3 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.56; 96.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for B4GALNT3 Gene

Disorders for B4GALNT3 Gene

Relevant External Links for B4GALNT3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for B4GALNT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B4GALNT3 Gene

Publications for B4GALNT3 Gene

  1. Molecular cloning and characterization of a novel human beta 1,4-N- acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. (PMID: 12966086) Sato T. … Narimatsu H. (J. Biol. Chem. 2003) 2 3 4 67
  2. New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. (PMID: 25803323) Costa V. … Ciccodicola A. (Oncotarget 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. I^1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells. (PMID: 25003232) Che M.I. … Huang M.C. (Oncotarget 2014) 3
  5. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases I^1,4-N-acetylgalactosaminyl transferase 3 (I^4GalNAc-T3) and I^4GalNAc-T4. (PMID: 22722937) Fiete D. … Baenziger J.U. (J. Biol. Chem. 2012) 3

Products for B4GALNT3 Gene

Sources for B4GALNT3 Gene