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B4GALNT3 Gene

protein-coding   GIFtS: 48
GCID: GC12P000569

Beta-1,4-N-Acetyl-Galactosaminyl Transferase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Beta-1,4-N-Acetyl-Galactosaminyl Transferase 31 2     Beta-1,4-N-Acetylgalactosaminyltransferase 32
Beta-1,4-N-Acetylgalactosaminyltransferase III2 3     beta4GalNAcT32
B4GalNAcT32 3     N-Acetyl-Beta-Glucosaminyl-Glycoprotein 4-Beta-N-
Acetylgalactosaminyltransferase2
Beta4GalNAc-T32 3     Beta4GalNAcT33
NGalNAc-T22 3     EC 2.4.1.2443
N-Acetyl-Beta-Glucosaminyl-Glycoprotein
4-Beta-N-Acetylgalactosaminyltransferase 22 3
     

External Ids:    HGNC: 241371   Entrez Gene: 2833582   Ensembl: ENSG000001390447   OMIM: 6122205   UniProtKB: Q6L9W63   

Export aliases for B4GALNT3 gene to outside databases

Previous GC identifer: GC12P000440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for B4GALNT3 Gene:
B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine
(LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 (PubMed
16728562)).(supplied by OMIM, Aug 2008)

GeneCards Summary for B4GALNT3 Gene:
B4GALNT3 (beta-1,4-N-acetyl-galactosaminyl transferase 3) is a protein-coding gene. GO annotations related to this gene include acetylgalactosaminyltransferase activity and N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is CSGALNACT1.

UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6
Function: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a
beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and
probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the B4GALNT3 gene promoter:
         Bach1   Pax-5   MEF-2   NCX/Ncx   Evi-1   MEF-2A   POU2F1   POU2F1a   SEF-1 (1)   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB4GALNT3 promoter sequence
   Search Chromatin IP Primers for B4GALNT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B4GALNT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.33   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.33

B4GALNT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B4GALNT3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P000569:  view genomic region     (about GC identifiers)

Start:
569,530 bp from pter      End:
672,675 bp from pter
Size:
103,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6 (See protein sequence)
Recommended Name: Beta-1,4-N-acetylgalactosaminyltransferase 3  
Size: 998 amino acids; 114975 Da
Sequence caution: Sequence=BAC05141.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD18454.1; Type=Miscellaneous discrepancy; Note=Probable intron retention;
Secondary accessions: Q6ZNC1 Q8N7T6

Explore the universe of human proteins at neXtProt for B4GALNT3: NX_Q6L9W6

Explore proteomics data for B4GALNT3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser70
  • Modification sites at PhosphoSitePlus

  • See B4GALNT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775864.3  
    ENSEMBL proteins: 
     ENSP00000266383   ENSP00000322953  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B4GT: Beta 4-glycosyltransferases

    2 InterPro protein domains:
     IPR011658 PA14
     IPR008428 Chond_GalNAc

    Graphical View of Domain Structure for InterPro Entry Q6L9W6

    ProtoNet protein and cluster: Q6L9W6

    1 Blocks protein domain: IPB011658 PA14

    UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6
    Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family


    Find genes that share domains with B4GALNT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B4GN3_HUMAN, Q6L9W6
    Function: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a
    beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and
    probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP +
    N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group

         Enzyme Number (IUBMB): EC 2.4.1.2441

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008376acetylgalactosaminyltransferase activity IDA12966086
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0033842N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA--
         
    Find genes that share ontologies with B4GALNT3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for B4galnt3):
     behavior/neurological  homeostasis/metabolism  pigmentation  vision/eye 

    Find genes that share phenotypes with B4GALNT3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for B4GALNT3

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    miRTarBase miRNAs that target B4GALNT3:
    hsa-mir-378a-3p (MIRT043861), hsa-mir-423-3p (MIRT042532), hsa-let-7a-5p (MIRT052526)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B4GN3_HUMAN, Q6L9W6: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes
    to apical Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with B4GALNT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for B4GALNT3
    Interactions:

        Search GeneGlobe Interaction Network for B4GALNT3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process IDA12966086

    Find genes that share ontologies with B4GALNT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for B4GALNT3 (B4GN3)

    3 HMDB Compounds for B4GALNT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    N-Acetylgalactosamine2-Acetamido-2-desoxy-b-D-talofuranose (see all 113)1811-31-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for B4GALNT3 gene: 
    NM_173593.3  

    Unigene Cluster for B4GALNT3:

    Beta-1,4-N-acetyl-galactosaminyl transferase 3
    Hs.504416  [show with all ESTs]
    Unigene Representative Sequence: AK131277
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266383(uc001qii.1) ENST00000535680 ENST00000544638 ENST00000540836
    ENST00000322843(uc001qij.1) ENST00000535402(uc001qik.1)
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    Additional mRNA sequence: 

    AB089940.1 AK093503.1 AK097681.1 AK131277.1 

    9 DOTS entries:

    DT.101955455  DT.308970  DT.100019906  DT.92040840  DT.91642367  DT.121126316  DT.75167858  DT.91906001 
    DT.95287914 

    Selected AceView cDNA sequences (see all 78):

    AX748171 AI460267 BQ447741 BX111532 AA911067 AI204181 BF222703 AI653170 
    BX505733 BI520398 CD642821 AI720529 AK093503 BX505732 AI654238 BF002388 
    BI825677 BE304866 AI650840 BM791086 AW148812 AI553784 AW196293 AK097681 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for B4GALNT3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                        
    SP2:                                                              -                                                         
    SP3:                                                                                                                        
    SP4:                                                              -                                                         
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for B4GALNT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    B4GALNT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGACAGAG
    B4GALNT3 Expression
    About this image


    B4GALNT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Stomach (Gastrointestinal Tract)
    B4GALNT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    B4GALNT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504416

    UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6
    Tissue specificity: Highly expressed in testis, colon and stomach. Weakly expressed in other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for B4GALNT3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B4galnt31 , 5 beta-1,4-N-acetyl-galactosaminyl transferase 31, 5 84.1(n)1
    83.76(a)1
      6 (56.94 cM)5
    3304061  NM_198884.11  NP_942585.11 
     1202030735 
    chicken
    (Gallus gallus)
    Aves B4GALNT31 beta-1,4-N-acetyl-galactosaminyl transferase 3 69.33(n)
    67.93(a)
      418150  XM_416381.4  XP_416381.4 
    lizard
    (Anolis carolinensis)
    Reptilia B4GALNT36
    beta-1,4-N-acetyl-galactosaminyl transferase 3
    55(a)
    1 ↔ 1
    5(11969736-12077422)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154752 Xenopus laevis transcribed sequences 81.03(n)    BJ037279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570914432   -- 72.81(n)    57091443 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG433136
    --
    12(a)
    1 → many
    X(12990125-13006475)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-226
    Protein MIG-22, isoform a
    11(a)
    1 → many
    III(8763291-8767342) WBGene00003253


    ENSEMBL Gene Tree for B4GALNT3 (if available)
    TreeFam Gene Tree for B4GALNT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for B4GALNT3 gene
    CSGALNACT12  CHSY32  CHPF2  CSGALNACT22  CHSY12  CHPF22  B4GALNT42  
    1 SIMAP similar gene for B4GALNT3 using alignment to 2 protein entries:     B4GN3_HUMAN (see all proteins):
    B4GALNT4

    Find genes that share paralogs with B4GALNT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for B4GALNT3 (see all 2974)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503652411,2
    Cuntested1666022(+) CACTTC/TGTCGT 2 F syn11Minor allele frequency- T:0.00EU 1319
    rs340475431,2
    C--442193(+) aaaaa-/ATTaGAGG 1 -- int11Minor allele frequency- ATT:0.00NA 2
    rs570440651,2
    C--467726(+) CTCTG-/AACAG 
            
    CTGCC
    1 -- int11Minor allele frequency- AACAG:0.00NA 2
    rs1822667051,2
    --504916(+) CACACA/GCTCCA 1 -- us2k10--------
    rs1428467151,2
    --567582(+) ACCAAC/TTAGAA 1 -- us2k10--------
    rs1460601041,2
    --567590(+) GAAAAG/TAAAAT 1 -- us2k10--------
    rs1998542211,2
    C--567744(+) TTTTG-/AGCAGG 1 -- us2k10--------
    rs113022041,2
    C--567769(+) TTTTT-/T/TTT 
            
    TTTTT
    2 -- us2k1 cds1 trp31NA 2
    rs1889216321,2
    --567874(+) CCCACC/TTCAGC 1 -- us2k10--------
    rs773316931,2
    C,F--568009(+) CTGTAG/AAAACT 1 -- us2k12Minor allele frequency- A:0.02WA NA 238

    HapMap Linkage Disequilibrium report for B4GALNT3 (569530 - 672675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for B4GALNT3 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745354CNV Deletion23290073
    esv1270072CNV Deletion17803354
    esv2745357CNV Deletion23290073
    esv2745358CNV Deletion23290073
    esv1142574CNV Deletion17803354
    esv1129945CNV Deletion17803354
    esv2745356CNV Deletion23290073
    esv2745355CNV Deletion23290073
    esv2745359CNV Deletion23290073
    esv2210414CNV Deletion18987734

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612220    OMIM disorders: --


    Find genes that share disorders with B4GALNT3           About GenesLikeMe

    Genetic Association Database (GAD): B4GALNT3
    Human Genome Epidemiology (HuGE) Navigator: B4GALNT3 (2 documents)

    Export disorders for B4GALNT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for B4GALNT3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with B4GALNT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human beta 1,4-N- acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. (PubMed id 12966086)1, 2, 3 Sato T.... Narimatsu H. (J. Biol. Chem. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PubMed id 20360844)1, 4 Arking D.E....Chugh S.S. (PLoS ONE 2010)
    4. Apical Golgi localization of N,N'-diacetyllactosediamine synthase, beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa. (PubMed id 16728562)1, 2 Ikehara Y.... Narimatsu H. (Glycobiology 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases I^1,4-N-acetylgalactosaminyl transferase 3 (I^4GalNAc-T3) and I^4GalNAc-T4. (PubMed id 22722940)1 Fiete D....Baenziger J.U. (J. Biol. Chem. 2012)
    7. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases I^1,4-N-acetylgalactosaminyl transferase 3 (I^4GalNAc-T3) and I^4GalNAc-T4. (PubMed id 22722937)1 Fiete D....Baenziger J.U. (J. Biol. Chem. 2012)
    8. A necessary and sufficient determinant for protein-selective glycosylation in vivo. (PubMed id 18048353)1 Miller E....Baenziger J.U. (J. Biol. Chem. 2008)
    9. Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells. (PubMed id 17579116)1 Huang J....Huang M.C. (Mol. Cancer Res. 2007)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283358 HGNC: 24137 AceView: B4GalNac-T3 Ensembl:ENSG00000139044 euGenes: HUgn283358
    ECgene: B4GALNT3 H-InvDB: B4GALNT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for B4GALNT3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALNT3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for B4GALNT3 gene:
    Search GeneIP for patents involving B4GALNT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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