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Aliases & Descriptions for B4GALNT3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B4GalNac-T3 1 | | Beta4GalNAc-T3 2, 3 | | Beta4GalNAcT3 3 | | EC 2.4.1.244 3 | | FLJ16224 1, 2 | | FLJ40362 1, 2 | | NGalNAc-T2 2, 3 |
| | | Descriptions |
|---|
| Beta-1,4-N-acetylgalactosaminyltransferase III 3 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 | | beta 1,4-N-acetylgalactosaminyltransferase-transferase 3 2 | | beta-1,4-N-acetyl-galactosaminyl transferase 3 2 |
|
| | Search outside databases for aliases for B4GALNT3 gene |
Summaries for B4GALNT3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B4GALNT3: B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM] UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6Function: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa |
Genomic Location for B4GALNT3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B4GALNT3 gene 
Entrez Gene cytogenetic band: 12p13.33 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33B4GALNT3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P000440:
(about GC identifiers)
Start:
|
439,804 bp from pter |
End:
|
541,319 bp from pter |
Size:
|
101,516 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009759.15
| Proteins for B4GALNT3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6 (See
protein sequence)Recommended Name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2 Size: 998 amino acids; 114975 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes to apical Golgi
Secondary accessions: Q6ZNC1 Q8N7T6Alternative splicing: 2 isoforms: Q6L9W6-1 Q6L9W6-2 REFSEQ proteins: NP_775864.3
ENSEMBL proteins: ENSP00000322953 ENSP00000266383
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B4GALNT3: Assays for B4GALNT3: | Protein
Domains/ Families for B4GALNT3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6L9W6
ProtoNet protein and cluster: Q6L9W6 1 Blocks protein family: IPB011658 PA14
UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family | Gene Function for B4GALNT3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173593
Applied Biosystems Silencer® siRNAs for B4GALNT3
Sigma-Aldrich siRNA for B4GALNT3  Sigma-Aldrich shRNA for B4GALNT3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173593                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173593                                  untagged cDNA clone in CMV expression vector: NM_173593 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_173593
UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6Function: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosaCatalytic activity: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl groupEnzyme Number (IUBMB): EC 2.4.1.244 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016740 | transferase activity |
IEA | -- | | GO:0033842 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity |
IEA | -- | About this table | Pathways & Interactions for B4GALNT3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| -- |
Drugs & Compounds for B4GALNT3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B4GALNT3
|
Transcripts for B4GALNT3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173593
Sigma-Aldrich siRNA for B4GALNT3  Sigma-Aldrich shRNA for B4GALNT3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_173593 REFSEQ mRNAs for B4GALNT3 gene: NM_173593.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_173593               OriGene GFP tagged cDNA clone in CMV expression vector: NM_173593                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173593                                  untagged cDNA clone in CMV expression vector: NM_173593  Additional cDNA sequence: AB089940.1 AK093503.1 AK097681.1 AK131277.1 9 DOTS entries: DT.101955455 DT.308970 DT.100019906 DT.92040840 DT.91642367 DT.121126316 DT.75167858 DT.91906001 DT.95287914 24/78 AceView cDNA sequences (see all 78
):BI520398 BX505733 AX748171 BF002388 BI825677 BX505732 AK093503 BQ447741 AI460267 BF222703 AI204181 AA911067 BX111532 AI654238 CD642821 AI653170 AI720529 AI369755 BX505894 AI650840 BI826822 CB216574 AK131277 AW148812
highest scoring ESTs for B4GALNT3:AA476456 AA758653 AB089940 AI654238 AK097681 BF970657 BI116830 CB216574 AA299607 AA341190 Unigene Cluster for B4GALNT3: Beta-1,4-N-acetyl-galactosaminyl transferase 3 Hs.504416 [show with all ESTs]Unigene Representative Sequence: AK131277
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for B4GALNT3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for B4GALNT3
2 Ensembl transcripts including schematic representations: ENST00000322843
ENST00000266383
|
Expression for B4GALNT3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B4GALNT3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B4GALNT3
1 / 2 / 3 8 probe-sets matching B4GALNT3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGGACAGAG
SOURCE GeneReport for Unigene cluster: Hs.504416 UniProtKB/Swiss-Prot: B4GN3_HUMAN, Q6L9W6Tissue specificity: Highly expressed in testis, colon and stomach. Weakly expressed in other tissues |
Orthologs for B4GALNT3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B4GALNT3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for B4GALNT3
ENSEMBL Gene Tree for B4GALNT3 | Paralogs for B4GALNT3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B4GALNT3 gene
- B4GALNT42
|
SNPs/Variants for B4GALNT3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B4GALNT3 (up to first 250kb)
|
Disorders & Mutations for B4GALNT3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612220
|
Medical News for B4GALNT3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B4GALNT3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for B4GALNT3 gene:- Molecular cloning and characterization of a novel human beta 1,4-N- acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. (PubMed id 12966086)2, 3, 4 Sato T.... Narimatsu H. (2003)
- Apical Golgi localization of N,N'-diacetyllactosediamine synthase, beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa. (PubMed id 16728562)3, 4 Ikehara Y.... Narimatsu H. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- A necessary and sufficient determinant for protein-selective glycosylation in vivo. (PubMed id 18048353)3 Miller E....Baenziger J.U. (2008)
- Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells. (PubMed id 17579116)3 Huang J....Huang M.C. (2007)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)4 Scherer S.E.... Gibbs R.A. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)3 Brandenberger R.... Stanton L.W. (2004)
|
Search for B4GALNT3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B4GALNT3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B4GALNT3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B4GALNT3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
|
| | | About This Section
| --
| Services for B4GALNT3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for B4GALNT3:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|