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B3GNTL1 Gene

protein-coding GIFtS: 43

GC17M078495

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
B3GNT8 ^¹, ², ³
BGnT-8 ^³
Beta3Gn-T8 ^³
Beta3GnTL1 ^³
EC 2.4.1.- ^³
MGC126253 ^²
MGC126256 ^²

Descriptions
BGnT-like protein 1 ^³
Beta1,3-N-acetylglucosaminyltransferase-like protein 1 ^³
Beta3Gn-T-like protein 1 ^³
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 ^²
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 ^²

External Ids
HGNC: 21727¹
Entrez Gene: 146712²
UniProtKB: Q67FW5³
Ensembl: ENSG00000175711⁷

Search outside databases for aliases for B3GNTL1 gene

Previous GC identifers: GC17M081580 GC17U900469

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: B3GNL_HUMAN, Q67FW5

Function: Putative glycosyltransferase (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the B3GNTL1 gene

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

B3GNTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M078495: (about GC identifiers)

Start:	78,494,956 bp from pter
End:	78,602,975 bp from pter
Size:	108,020 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010663.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: B3GNL_HUMAN, Q67FW5 (See protein sequence)

Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1

Size: 361 amino acids; 40782 Da

Secondary accessions: Q6GV30 Q8WUT3

REFSEQ proteins: NP_001009905.1

ENSEMBL proteins:

ENSP00000319979

Human Recombinant Proteins

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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for B3GNTL1:

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Assays for B3GNTL1:

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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q67FW5

ProtoNet protein and cluster: Q67FW5

1 Blocks protein family: IPB001173 Glycosyl transferase

UniProtKB/Swiss-Prot: B3GNL_HUMAN, Q67FW5

Similarity: Belongs to the glycosyltransferase 2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (B3GNTL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001009905

Applied Biosystems Silencer® siRNAs for B3GNTL1

Sigma-Aldrich siRNA for B3GNTL1

Sigma-Aldrich shRNA for B3GNTL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001009905
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001009905
untagged cDNA clones in CMV expression vector (see all 2): NM_001009905

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001009905

UniProtKB/Swiss-Prot: B3GNL_HUMAN, Q67FW5

Function: Putative glycosyltransferase (Potential)

Enzyme Number (IUBMB): EC 2.4.1.-

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for B3GNTL1 (Q67FW5²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
MPP3 Q13368² MINT-64790
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for B3GNTL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (B3GNTL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001009905

Sigma-Aldrich siRNA for B3GNTL1

Sigma-Aldrich shRNA for B3GNTL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001009905

REFSEQ mRNAs for B3GNTL1 gene:

NM_001009905.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001009905

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001009905
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001009905
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001009905

Additional cDNA sequence:

AK054757.1 AK126018.1 AY304503.1 AY634364.1 BC019623.1 BC035891.1 BC041588.1 BC065543.1

BC110528.1 BC110529.1 U79265.1

13 DOTS entries:

DT.312051 DT.312050 DT.97776858 DT.307665 DT.100673985 DT.101962460 DT.100010112 DT.108355

DT.97790524 DT.100711913 DT.120974050 DT.75146335 DT.99997957

24/114 AceView cDNA sequences (see all 114 ):

U79265 AY634364 F13312 BI253904 AA338914 Z41581 AA428168 BM542160

AK054757 AA621585 BU849242 AA845994 BM709913 AI346329 BU931205 BC041588

BQ632090 BU845472 BU623325 BC019623 AW166378 AI091322 BI020674 BM976676

highest scoring ESTs for B3GNTL1:

U79265 AA079400 AA134647 AA613445 AA621585 AA845994 AI240973 AI375397 AI859793 AK126018

Unigene Cluster for B3GNTL1:

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1

Hs.718480 [show with all ESTs]

Unigene Representative Sequence: AK126018

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000320865

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

B3GNTL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for B3GNTL1

¹ / ² / ³

6 probe-sets matching B3GNTL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41006_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.14	U79265	0.80	1.00	0.91	1
42436_at²^{, 3}	U95-B	1	1.00	1.00	0.95	0.87	AA428168	0.60	0.75	0.68	1
213589_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW468201	0.40	1.00	0.76	1
215055_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U79265	0.80	1.00	0.91	1
213589_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215055_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks B3GNTL1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: TGGCCAAGGC

SOURCE GeneReport for Unigene cluster: Hs.718480
UniProtKB/Swiss-Prot: B3GNL_HUMAN, Q67FW5
Tissue specificity: Widely expressed. Highly expressed in adult pancreas. Expressed at moderate
level in kidney, spleen, thymus, prostate, testis and ovary. Weakly expressed in small intestine,
colon, peripheral blood leukocyte and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for B3GNTL1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	B3GNTL1¹	--	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like more	89.64(n) 84.87(a)	747667 XM_001157868.1 XP_001157868.1
cow (Bos taurus)	B3GNTL1¹	--	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like more	86.07(n) 89.93(a)	617397 XM_869650.2 XP_874743.2
rat (Rattus norvegicus)	B3gntl1¹	--	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like more	82.18(n) 86.21(a)	367384 NM_001015035.1 NP_001015035.1
mouse (Mus musculus)	B3gntl1^{1, 5}	11⁵	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like more^{1, 5}	82.36(n)¹ 85.47(a)¹	210004¹ NM_178664.3¹ NP_848779.1¹ AK031361⁵ AK043722⁵ (see all 16)
chicken (Gallus gallus)	B3GNTL1¹	--	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like more	69.21(n) 73.61(a)	417333 XM_415599.2 XP_415599.2

About this table Species with no ortholog for B3GNTL1

ENSEMBL Gene Tree for B3GNTL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1168 NCBI SNPs in B3GNTL1 are shown (see all 1168 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 198)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11077950^1,2	A,C,F,H	78495039(+)	`GGTCAC/TGTGGT`	1	--	ut3¹ ese³		4		EU EA WA	412
	rs7225887^1,2	A,C,F,H	78498133(+)	`AAAGGC/TGCCCC`	1	A/T	mis¹		11		EU EA WA NA	972
--	rs7212795^1,2	A,C,F	78603123(+)	`ggTCGC/TCGCCT`	1	--	ng3¹		3		NA	130
--	rs8073945^1,2	A,C	78604104(+)	`TGCCCA/GGGAGT`	1	--	ng3¹		0	--	--	--	--
--	rs8073908^1,2	A,C	78604053(+)	`TGCCCA/GGGAGT`	1	--	ng3¹		0	--	--	--	--
	rs9910909^1,2	A,C	78603437(+)	`CAGACA/GCGGTA`	1	--	ng3¹		0	--	--	--	--
--	rs7221891^1,2	A	78603390(+)	`GCTACC/TTGACC`	1	--	ng3¹		0	--	--	--	--
--	rs8073922^1,2	A	78604076(+)	`CCACCA/GCGAGG`	1	--	ng3¹		0	--	--	--	--
--	rs8075062^1,2	C	78604085(+)	`GGTCCC/TCCAGG`	1	--	ng3¹		0	--	--	--	--
--	rs8075060^1,2	A	78604077(+)	`CACCGC/GGAGGT`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for B3GNTL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for B3GNTL1 gene:

Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase. (PubMed id 15560372)^{3, 4} Zheng H.... Mao Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)³ Yu W....Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)³ Andersson B....Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 146712	HGNC: 21727	AceView: LOC146712	Ensembl:ENSG00000175711	euGenes: HUgn146712
ECgene: B3GNTL1	H-InvDB: B3GNTL1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for B3GNTL1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for B3GNTL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for B3GNTL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for B3GNTL1		Antibodies for B3GNTL1
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B3GNTL1 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for B3GNTL1

Summaries
for B3GNTL1

Genomic Location
for B3GNTL1

Proteins
for B3GNTL1

Protein Domains/
Families
for B3GNTL1

Gene Function
for B3GNTL1

Pathways & Interactions
for B3GNTL1

Drugs & Compounds
for B3GNTL1

Transcripts
for B3GNTL1

Expression
for B3GNTL1

Orthologs
for B3GNTL1

Paralogs
for B3GNTL1

SNPs/Variants
for B3GNTL1

Disorders & Mutations
for B3GNTL1

Medical News
for B3GNTL1

Publications
for B3GNTL1

Search for B3GNTL1

Genome Databases showing B3GNTL1

Other Databases showing B3GNTL1

Specialized Databases showing B3GNTL1

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

B3GNTL1 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor B3GNTL1

Summariesfor B3GNTL1

Genomic Locationfor B3GNTL1

Proteinsfor B3GNTL1

Protein Domains/Familiesfor B3GNTL1

Gene Functionfor B3GNTL1

Pathways & Interactionsfor B3GNTL1

Drugs & Compoundsfor B3GNTL1

Transcriptsfor B3GNTL1

Expression for B3GNTL1

Orthologsfor B3GNTL1

Paralogsfor B3GNTL1

SNPs/Variantsfor B3GNTL1

Disorders & Mutationsfor B3GNTL1

Medical Newsfor B3GNTL1

Publicationsfor B3GNTL1

Search for B3GNTL1

Genome Databases showing B3GNTL1

Other Databases showing B3GNTL1

Specialized Databases showing B3GNTL1

Licensable Technologiesfor B3GNTL1

Servicesfor B3GNTL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for B3GNTL1

Summaries
for B3GNTL1

Genomic Location
for B3GNTL1

Proteins
for B3GNTL1

Protein Domains/
Families
for B3GNTL1

Gene Function
for B3GNTL1

Pathways & Interactions
for B3GNTL1

Drugs & Compounds
for B3GNTL1

Transcripts
for B3GNTL1

Expression
for B3GNTL1

Orthologs
for B3GNTL1

Paralogs
for B3GNTL1

SNPs/Variants
for B3GNTL1

Disorders & Mutations
for B3GNTL1

Medical News
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Publications
for B3GNTL1

Licensable Technologies
for B3GNTL1

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