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Aliases for B3GNT9 Gene

Aliases for B3GNT9 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 9 2 3 5
  • Beta-1,3-N-Acetylglucosaminyltransferase 9 3 4
  • Beta-1,3-Gn-T9 3 4
  • Beta3Gn-T9 3 4
  • BGnT-9 3 4
  • Beta-1,3-Galactosyltransferase-Related Protein 3
  • EC 2.4.1.- 4

External Ids for B3GNT9 Gene

Previous GeneCards Identifiers for B3GNT9 Gene

  • GC16M065740
  • GC16M067182
  • GC16M053055

Summaries for B3GNT9 Gene

GeneCards Summary for B3GNT9 Gene

B3GNT9 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 9) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. GO annotations related to this gene include transferase activity, transferring glycosyl groups and galactosyltransferase activity. An important paralog of this gene is B3GNT7.

Additional gene information for B3GNT9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT9 Gene

Genomics for B3GNT9 Gene

Regulatory Elements for B3GNT9 Gene

Enhancers for B3GNT9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H066977 1.5 Ensembl ENCODE dbSUPER 11.2 +173.4 173414 0 HDGF ARID4B SIN3A ZNF2 SLC30A9 GLIS2 ZNF143 RUNX3 DEK SP5 CES2 ELMO3 CBFB B3GNT9 FBXL8 TRADD HSF4 C16orf70 RRAD CDH16
GH16H067027 1.4 ENCODE dbSUPER 11.1 +121.7 121723 3 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 EDC4 ACD CENPT CTCF NAE1 C16orf70 B3GNT9 ENSG00000259804 ELMO3 ENSG00000260465
GH16H066960 1.2 Ensembl ENCODE 11.3 +190.1 190094 1 HDGF PKNOX1 ARNT ARID4B ZNF2 ZNF143 ATF7 DEK REST MIER2 FBXL8 TRADD HSF4 CES2 RRAD CDH16 FAM96B B3GNT9 CBFB MIR328
GH16H066879 1.1 ENCODE 10.2 +270.4 270442 2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF416 ZNF143 CES2 EDC4 CTCF ENSG00000260465 CDH16 RRAD NAE1 ZDHHC1 FAM96B ACD
GH16H066871 1.5 FANTOM5 ENCODE 7.3 +277.4 277374 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 CES2 E2F4 CA7 PLEKHG4 ZDHHC1 ENSG00000260465 FAM96B FBXL8 CTCF TRADD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B3GNT9 on UCSC Golden Path with GeneCards custom track

Promoters for B3GNT9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087067 514 1001 HDAC1 ARID4B SIN3A DMAP1 EGR1 PAF1 SMARCA5 MXD4 USF2 ZNF398

Genomic Location for B3GNT9 Gene

Chromosome:
16
Start:
67,148,102 bp from pter
End:
67,151,214 bp from pter
Size:
3,113 bases
Orientation:
Minus strand

Genomic View for B3GNT9 Gene

Genes around B3GNT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT9 Gene

Proteins for B3GNT9 Gene

  • Protein details for B3GNT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX72-B3GN9_HUMAN
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
    Protein Accession:
    Q6UX72
    Secondary Accessions:
    • Q96EK0

    Protein attributes for B3GNT9 Gene

    Size:
    402 amino acids
    Molecular mass:
    43751 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC012191; Type=Frameshift; Positions=81; Evidence={ECO:0000305};

neXtProt entry for B3GNT9 Gene

Post-translational modifications for B3GNT9 Gene

  • Glycosylation at posLast=329329
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT9 Gene

Domains & Families for B3GNT9 Gene

Gene Families for B3GNT9 Gene

Protein Domains for B3GNT9 Gene

Suggested Antigen Peptide Sequences for B3GNT9 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UX72

UniProtKB/Swiss-Prot:

B3GN9_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT9: view

Function for B3GNT9 Gene

Enzyme Numbers (IUBMB) for B3GNT9 Gene

Gene Ontology (GO) - Molecular Function for B3GNT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GNT9: view
genes like me logo Genes that share phenotypes with B3GNT9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for B3GNT9

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for B3GNT9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for B3GNT9 Gene

Localization for B3GNT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT9 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B3GNT9 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for B3GNT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001650 fibrillar center IDA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT9: view

Pathways & Interactions for B3GNT9 Gene

genes like me logo Genes that share pathways with B3GNT9: view

Interacting Proteins for B3GNT9 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400157%0d%0a9606.ENSP00000302021%0d%0a9606.ENSP00000365473%0d%0a9606.ENSP00000357380%0d%0a9606.ENSP00000311364%0d%0a9606.ENSP00000416753%0d%0a
Selected Interacting proteins: ENSP00000400157 Q6UX72-B3GN9_HUMAN for B3GNT9 Gene via STRING IID

Gene Ontology (GO) - Biological Process for B3GNT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with B3GNT9: view

No data available for SIGNOR curated interactions for B3GNT9 Gene

Drugs & Compounds for B3GNT9 Gene

No Compound Related Data Available

Transcripts for B3GNT9 Gene

mRNA/cDNA for B3GNT9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(141) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GNT9 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for B3GNT9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT9 Gene

No ASD Table

Relevant External Links for B3GNT9 Gene

GeneLoc Exon Structure for
B3GNT9
ECgene alternative splicing isoforms for
B3GNT9

Expression for B3GNT9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B3GNT9 Gene

Protein differential expression in normal tissues from HIPED for B3GNT9 Gene

This gene is overexpressed in Serum (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GNT9 Gene



Protein tissue co-expression partners for B3GNT9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of B3GNT9 Gene:

B3GNT9

SOURCE GeneReport for Unigene cluster for B3GNT9 Gene:

Hs.744158

Evidence on tissue expression from TISSUES for B3GNT9 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with B3GNT9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT9 Gene

Orthologs for B3GNT9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GNT9 33
  • 86.36 (n)
dog
(Canis familiaris)
Mammalia B3GNT9 33 34
  • 85.17 (n)
rat
(Rattus norvegicus)
Mammalia B3gnt9 33
  • 80.2 (n)
mouse
(Mus musculus)
Mammalia B3gnt9 33 16 34
  • 80.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT9 34
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves B3GNT9 33 34
  • 62.72 (n)
lizard
(Anolis carolinensis)
Reptilia B3GNT9 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt9 33
  • 54.12 (n)
zebrafish
(Danio rerio)
Actinopterygii b3gnt9 33 34
  • 56.4 (n)
Species where no ortholog for B3GNT9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT9 Gene

ENSEMBL:
Gene Tree for B3GNT9 (if available)
TreeFam:
Gene Tree for B3GNT9 (if available)

Paralogs for B3GNT9 Gene

(6) SIMAP similar genes for B3GNT9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT9: view

Variants for B3GNT9 Gene

Sequence variations from dbSNP and Humsavar for B3GNT9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000042696 -- 67,151,388(+) CTGTC(-/T)TCTTA upstream-variant-2KB
rs1000114051 -- 67,152,868(+) AACTG(A/T)GTCCA upstream-variant-2KB
rs1000531733 -- 67,148,098(+) AGAAA(A/G)ATGTA downstream-variant-500B, utr-variant-3-prime
rs1000562328 -- 67,151,202(+) TAGCT(C/G)CCCCA upstream-variant-2KB
rs1000963083 -- 67,148,559(+) TTGGT(A/T)TTTTG intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for B3GNT9 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV loss 19592680
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for B3GNT9 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GNT9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
B3GNT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT9 Gene

Disorders for B3GNT9 Gene

Relevant External Links for B3GNT9

Genetic Association Database (GAD)
B3GNT9
Human Genome Epidemiology (HuGE) Navigator
B3GNT9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT9

No disorders were found for B3GNT9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT9 Gene

Publications for B3GNT9 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K … Vidal M (Nature methods 2009) 3 60
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 60
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X … Balch WE (Cell 2006) 3 60

Products for B3GNT9 Gene

Sources for B3GNT9 Gene

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