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Aliases for B3GNT8 Gene

Aliases for B3GNT8 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8 2 3
  • B3GALT7 3 4 6
  • BGALT15 3 4 6
  • UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide 7 2 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 8 3 4
  • Beta-1,3-Gn-T8 3 4
  • Beta3Gn-T8 3 4
  • BGnT-8 3 4
  • Beta1,3-N-Acetylglucosaminyltransferase 8 3
  • Beta Galactosyltransferase BGALT15 3
  • EC 2.4.1.- 4

External Ids for B3GNT8 Gene

Previous Symbols for B3GNT8 Gene

  • B3GALT7

Summaries for B3GNT8 Gene

GeneCards Summary for B3GNT8 Gene

B3GNT8 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include galactosyltransferase activity and protein N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT8 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT8 Gene

Genomics for B3GNT8 Gene

Genomic Location for B3GNT8 Gene

Start:
41,425,359 bp from pter
End:
41,428,730 bp from pter
Size:
3,372 bases
Orientation:
Minus strand

Genomic View for B3GNT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GNT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT8 Gene

Regulatory Elements for B3GNT8 Gene

Proteins for B3GNT8 Gene

  • Protein details for B3GNT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7M8-B3GN8_HUMAN
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Protein Accession:
    Q7Z7M8
    Secondary Accessions:

    Protein attributes for B3GNT8 Gene

    Size:
    397 amino acids
    Molecular mass:
    43396 Da
    Quaternary structure:
    • Interacts with B3GNT2; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.

neXtProt entry for B3GNT8 Gene

Proteomics data for B3GNT8 Gene at MOPED

Post-translational modifications for B3GNT8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn57

Other Protein References for B3GNT8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT8 Gene

Domains for B3GNT8 Gene

Gene Families for B3GNT8 Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GNT8 Gene

Suggested Antigen Peptide Sequences for B3GNT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7M8

UniProtKB/Swiss-Prot:

B3GN8_HUMAN
Family:
  • Belongs to the glycosyltransferase 31 family.:
    • Q7Z7M8
genes like me logo Genes that share domains with B3GNT8: view

Function for B3GNT8 Gene

Molecular function for B3GNT8 Gene

UniProtKB/Swiss-Prot Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.
UniProtKB/Swiss-Prot Induction: Up-regulated in colon cancer.

Enzyme Numbers (IUBMB) for B3GNT8 Gene

Gene Ontology (GO) - Molecular Function for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0016262 protein N-acetylglucosaminyltransferase activity IDA 15620693
genes like me logo Genes that share ontologies with B3GNT8: view

miRNA for B3GNT8 Gene

miRTarBase miRNAs that target B3GNT8

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for B3GNT8 Gene

Localization for B3GNT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT8 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GNT8 Gene COMPARTMENTS Subcellular localization image for B3GNT8 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with B3GNT8: view

Pathways for B3GNT8 Gene

genes like me logo Genes that share pathways with B3GNT8: view

Pathways by source for B3GNT8 Gene

UniProtKB/Swiss-Prot Q7Z7M8-B3GN8_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT8 Gene

Gene Ontology (GO) - Biological Process for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0030311 poly-N-acetyllactosamine biosynthetic process IDA 15620693
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with B3GNT8: view

Compounds for B3GNT8 Gene

(1) HMDB Compounds for B3GNT8 Gene

Compound Synonyms Cas Number PubMed IDs
Poly-N-acetyllactosamine
  • Poly(N-acetyllactosamine)
82441-98-3
genes like me logo Genes that share compounds with B3GNT8: view

Transcripts for B3GNT8 Gene

mRNA/cDNA for B3GNT8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GNT8 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for B3GNT8 Gene

GeneLoc Exon Structure for
B3GNT8
ECgene alternative splicing isoforms for
B3GNT8

Expression for B3GNT8 Gene

mRNA expression in normal human tissues for B3GNT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT8 Gene

This gene is overexpressed in Whole Blood (20.1) and Esophagus - Mucosa (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for B3GNT8 Gene

SOURCE GeneReport for Unigene cluster for B3GNT8 Gene Hs.441681

mRNA Expression by UniProt/SwissProt for B3GNT8 Gene

Q7Z7M8-B3GN8_HUMAN
Tissue specificity: Highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, and ileum, and weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, and testis. Not detected in colon. Differentially expressed in human tumor cell lines.
genes like me logo Genes that share expressions with B3GNT8: view

Orthologs for B3GNT8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT8 35
  • 99.5 (n)
  • 99.24 (a)
B3GNT8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia B3GNT8 35
  • 85.47 (n)
  • 84.13 (a)
B3GNT8 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GNT8 35
  • 84.05 (n)
  • 83.12 (a)
mouse
(Mus musculus)
Mammalia B3gnt8 35
  • 80.38 (n)
  • 77.63 (a)
B3gnt8 16
B3gnt8 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia B3GNT8 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3gnt8 35
  • 80.81 (n)
  • 77.89 (a)
lizard
(Anolis carolinensis)
Reptilia B3GNT8 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii b3gnt2l 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.163 36
  • 21 (a)
OneToMany
Species with no ortholog for B3GNT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT8 Gene

ENSEMBL:
Gene Tree for B3GNT8 (if available)
TreeFam:
Gene Tree for B3GNT8 (if available)

Paralogs for B3GNT8 Gene

Selected SIMAP similar genes for B3GNT8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT8: view

Variants for B3GNT8 Gene

Sequence variations from dbSNP and Humsavar for B3GNT8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs284660 -- 41,426,179(-) GTGGC(A/C)TGGGA synonymous-codon, reference
rs284661 -- 41,426,215(-) CCGGT(A/G)GGTGA synonymous-codon, reference
rs284662 - 41,426,370(-) GTGGC(A/G)GCCAA reference, missense
rs284663 -- 41,426,707(-) ATCGA(A/G)TGGAC synonymous-codon, reference
rs364310 -- 41,425,549(-) TGGCC(C/T)GGGCC utr-variant-3-prime

Relevant External Links for B3GNT8 Gene

HapMap Linkage Disequilibrium report
B3GNT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for B3GNT8 Gene

Disorders for B3GNT8 Gene

No disorders were found for B3GNT8 Gene.

No data available for UniProtKB/Swiss-Prot for B3GNT8 Gene

Publications for B3GNT8 Gene

  1. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. (PMID: 15620693) Ishida H. … Narimatsu H. (FEBS Lett. 2005) 3 4 23
  2. Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family. (PMID: 15486459) Huang C. … Yu L. (Glycoconj. J. 2004) 2 3 4
  3. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. (PMID: 18826941) Seko A. … Yamashita K. (J. Biol. Chem. 2008) 3 4
  4. Regulation of MMP-2 expression and activity by I^-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells. (PMID: 20963502) Shen L. … Wu S. (Mol. Biol. Rep. 2011) 3
  5. Down-regulation of I^-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer. (PMID: 21468598) Liu Z. … Wu S. (Mol Med Rep 2011) 3

Products for B3GNT8 Gene

Sources for B3GNT8 Gene

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