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Aliases for B3GNT8 Gene

Aliases for B3GNT8 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8 2 3 5
  • UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide 7 2 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 8 3 4
  • Beta-1,3-Gn-T8 3 4
  • Beta3Gn-T8 3 4
  • B3GALT7 3 4
  • BGALT15 3 4
  • BGnT-8 3 4
  • Beta1,3-N-Acetylglucosaminyltransferase 8 3
  • Beta Galactosyltransferase BGALT15 3
  • EC 2.4.1.- 4

External Ids for B3GNT8 Gene

Previous HGNC Symbols for B3GNT8 Gene

  • B3GALT7

Previous GeneCards Identifiers for B3GNT8 Gene

  • GC00U909458
  • GC19M046626
  • GC19M041935
  • GC19M038363

Summaries for B3GNT8 Gene

GeneCards Summary for B3GNT8 Gene

B3GNT8 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. GO annotations related to this gene include galactosyltransferase activity and protein N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT6.

UniProtKB/Swiss-Prot for B3GNT8 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.

Additional gene information for B3GNT8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT8 Gene

Genomics for B3GNT8 Gene

Regulatory Elements for B3GNT8 Gene

Enhancers for B3GNT8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H041217 1.8 FANTOM5 ENCODE dbSUPER 4.2 +205.8 205783 10 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF416 ZNF526 SNRPA ENSG00000269843 ZNF574 HNRNPUL1 CYP2G1P CCDC97 ENSG00000271299 CYP2G2P AXL
GH19H041440 0.6 ENCODE 9.3 -13.9 -13860 3 ELF3 KLF1 ZC3H11A NFIC ZNF366 IKZF1 GLIS1 KLF9 PRDM1 EXOSC5 B3GNT8 PCAT19 B9D2 DMAC2 TMEM91 ENSG00000277136 ERICH4
GH19H041135 0.8 FANTOM5 Ensembl ENCODE 5 +293.0 292956 1 CYP2F1 ENSG00000205041 B3GNT8 BCKDHA CYP2T3P PIR51429
GH19H041430 1.7 VISTA ENCODE dbSUPER 0.7 -2.9 -2946 2 HDGF ATF1 ARNT ZSCAN4 ZNF133 GLI4 RAD21 YY1 TCF12 GATA2 SNRPA ZNF526 ENSG00000269843 HNRNPUL1 EXOSC5 CCDC97 ITPKC B9D2 TGFB1 TMEM91
GH19H041424 1.2 ENCODE dbSUPER 0.7 +1.8 1845 4 HDGF ARNT ZFP64 ARID4B DMAP1 ZNF766 GLIS2 GATA2 ELK1 ZNF416 TMEM91 EXOSC5 DMAC2 ZNF574 SPTBN4 BCKDHA TGFB1 MEGF8 GRIK5 CCDC97
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B3GNT8 on UCSC Golden Path with GeneCards custom track

Promoters for B3GNT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109656 1256 1601 HDGF ARNT ZFP64 ARID4B DMAP1 ZNF766 GLIS2 GATA2 ZNF416 SP3

Genomic Location for B3GNT8 Gene

Chromosome:
19
Start:
41,425,359 bp from pter
End:
41,428,856 bp from pter
Size:
3,498 bases
Orientation:
Minus strand

Genomic View for B3GNT8 Gene

Genes around B3GNT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT8 Gene

Proteins for B3GNT8 Gene

  • Protein details for B3GNT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7M8-B3GN8_HUMAN
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Protein Accession:
    Q7Z7M8

    Protein attributes for B3GNT8 Gene

    Size:
    397 amino acids
    Molecular mass:
    43396 Da
    Quaternary structure:
    • Interacts with B3GNT2; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.

neXtProt entry for B3GNT8 Gene

Post-translational modifications for B3GNT8 Gene

  • Glycosylation at Asn57
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT8 Gene

Domains & Families for B3GNT8 Gene

Gene Families for B3GNT8 Gene

Protein Domains for B3GNT8 Gene

Suggested Antigen Peptide Sequences for B3GNT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7M8

UniProtKB/Swiss-Prot:

B3GN8_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT8: view

Function for B3GNT8 Gene

Molecular function for B3GNT8 Gene

UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.
UniProtKB/Swiss-Prot Induction:
Up-regulated in colon cancer.

Enzyme Numbers (IUBMB) for B3GNT8 Gene

Phenotypes From GWAS Catalog for B3GNT8 Gene

Gene Ontology (GO) - Molecular Function for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS --
GO:0016262 protein N-acetylglucosaminyltransferase activity IDA 15620693
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GNT8: view
genes like me logo Genes that share phenotypes with B3GNT8: view

Animal Model Products

CRISPR Products

miRNA for B3GNT8 Gene

miRTarBase miRNAs that target B3GNT8

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for B3GNT8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT8 Gene

Localization for B3GNT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT8 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B3GNT8 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 1

Gene Ontology (GO) - Cellular Components for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with B3GNT8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for B3GNT8 Gene

Pathways & Interactions for B3GNT8 Gene

genes like me logo Genes that share pathways with B3GNT8: view

UniProtKB/Swiss-Prot Q7Z7M8-B3GN8_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT8 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000312700%0d%0a9606.ENSP00000302021%0d%0a9606.ENSP00000416753%0d%0a9606.ENSP00000357380%0d%0a9606.ENSP00000311364%0d%0a9606.ENSP00000365473%0d%0a
Selected Interacting proteins: Q7Z7M8-B3GN8_HUMAN ENSP00000312700 for B3GNT8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for B3GNT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0030311 poly-N-acetyllactosamine biosynthetic process IDA 15620693
genes like me logo Genes that share ontologies with B3GNT8: view

No data available for SIGNOR curated interactions for B3GNT8 Gene

Drugs & Compounds for B3GNT8 Gene

(1) Additional Compounds for B3GNT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Poly-N-acetyllactosamine
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-Glucose
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose homopolymer
  • N-Acetyl-4-O-beta-D-galactopyranosyl-D-glucosamine
  • N-Acetyl-lactosamine
  • O-beta-D-Galactopyranosyl-(14)-2-deoxy-2-acetamido-D-glucose
82441-98-3
genes like me logo Genes that share compounds with B3GNT8: view

Transcripts for B3GNT8 Gene

mRNA/cDNA for B3GNT8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GNT8 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for B3GNT8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for B3GNT8 Gene

GeneLoc Exon Structure for
B3GNT8
ECgene alternative splicing isoforms for
B3GNT8

Expression for B3GNT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B3GNT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT8 Gene

This gene is overexpressed in Whole Blood (x20.1) and Esophagus - Mucosa (x7.4).

Protein differential expression in normal tissues from HIPED for B3GNT8 Gene

This gene is overexpressed in Serum (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GNT8 Gene



Protein tissue co-expression partners for B3GNT8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of B3GNT8 Gene:

B3GNT8

SOURCE GeneReport for Unigene cluster for B3GNT8 Gene:

Hs.441681

mRNA Expression by UniProt/SwissProt for B3GNT8 Gene:

Q7Z7M8-B3GN8_HUMAN
Tissue specificity: Highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, and ileum, and weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, and testis. Not detected in colon. Differentially expressed in human tumor cell lines.
genes like me logo Genes that share expression patterns with B3GNT8: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT8 Gene

Orthologs for B3GNT8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT8 33 34
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia B3GNT8 33 34
  • 85.47 (n)
dog
(Canis familiaris)
Mammalia B3GNT8 33
  • 84.05 (n)
rat
(Rattus norvegicus)
Mammalia B3gnt8 33
  • 80.81 (n)
mouse
(Mus musculus)
Mammalia B3gnt8 33 16 34
  • 80.38 (n)
oppossum
(Monodelphis domestica)
Mammalia B3GNT8 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B3GNT8 34
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii b3gnt2l 34
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.163 34
  • 21 (a)
OneToMany
Species where no ortholog for B3GNT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT8 Gene

ENSEMBL:
Gene Tree for B3GNT8 (if available)
TreeFam:
Gene Tree for B3GNT8 (if available)

Paralogs for B3GNT8 Gene

(6) SIMAP similar genes for B3GNT8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT8: view

Variants for B3GNT8 Gene

Sequence variations from dbSNP and Humsavar for B3GNT8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10421626 Likely benign 41,424,917(+) TGGAC(A/G)TGGCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs528816040 Uncertain significance 41,424,942(+) ACTTG(C/T)GCAGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs564517344 Uncertain significance 41,424,932(+) AGCCT(A/G)TGGAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs886054463 Uncertain significance 41,424,943(+) CTTGC(A/G)CAGGT downstream-variant-500B, utr-variant-3-prime
rs886054464 Uncertain significance 41,424,973(+) CACGA(A/G)TAAAC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for B3GNT8 Gene

Variant ID Type Subtype PubMed ID
nsv953578 CNV deletion 24416366

Variation tolerance for B3GNT8 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GNT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
B3GNT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT8 Gene

Disorders for B3GNT8 Gene

Relevant External Links for B3GNT8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT8

No disorders were found for B3GNT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT8 Gene

Publications for B3GNT8 Gene

  1. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. (PMID: 15620693) Ishida H … Narimatsu H (FEBS letters 2005) 3 4 22 60
  2. Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family. (PMID: 15486459) Huang C … Yu L (Glycoconjugate journal 2004) 2 3 4 60
  3. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. (PMID: 18826941) Seko A … Yamashita K (The Journal of biological chemistry 2008) 3 4 60
  4. Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901. (PMID: 27459970) Jiang Z … Wu S (Oncology reports 2016) 3 60
  5. Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans. (PMID: 25269761) Shen L … Wu S (International journal of oncology 2014) 3 60

Products for B3GNT8 Gene

Sources for B3GNT8 Gene

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