Aliases for B3GNT8 Gene
Aliases for B3GNT8 Gene
External Ids for B3GNT8 Gene
- HGNC: 24139
- Entrez Gene: 374907
- Ensembl: ENSG00000177191
- OMIM: 615357
- UniProtKB: Q7Z7M8
Previous HGNC Symbols for B3GNT8 Gene
- B3GALT7
Previous GeneCards Identifiers for B3GNT8 Gene
- GC00U909458
- GC19M046626
- GC19M041935
- GC19M038363
Summaries for B3GNT8 Gene
GeneCards Summary for B3GNT8 Gene
B3GNT8 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. GO annotations related to this gene include galactosyltransferase activity and protein N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT2.
UniProtKB/Swiss-Prot for B3GNT8 Gene
-
Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT8 Gene
Genomics for B3GNT8 Gene
Regulatory Elements for B3GNT8 Gene
Regulatory Element Products
Genomic Location for B3GNT8 Gene
- Chromosome:
- 19
- Start:
- 41,425,359 bp from pter
- End:
- 41,428,856 bp from pter
- Size:
- 3,498 bases
- Orientation:
- Minus strand
Genomic View for B3GNT8 Gene
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for B3GNT8 Gene
Proteins for B3GNT8 Gene
-
Protein details for B3GNT8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z7M8-B3GN8_HUMAN
- Recommended name:
- UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
- Protein Accession:
- Q7Z7M8
Protein attributes for B3GNT8 Gene
- Size:
- 397 amino acids
- Molecular mass:
- 43396 Da
- Quaternary structure:
-
- Interacts with B3GNT2; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.
Protein Expression for B3GNT8 Gene
Post-translational modifications for B3GNT8 Gene
Other Protein References for B3GNT8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for B3GNT8
-
Abcam antibodies for B3GNT8
- Invitrogen Antibodies for B3GNT8
- Search GeneTex for Antibodies for B3GNT8
Protein Products
-
OriGene Purified Proteins for B3GNT8
- Search Origene for MassSpec and Protein Over-expression Lysates for B3GNT8
- Origene Custom Protein Services for B3GNT8
- Novus Biologicals proteins for B3GNT8
- Search GeneTex for Proteins for B3GNT8
Assay Products
No data available for DME Specific Peptides for B3GNT8 Gene
Domains & Families for B3GNT8 Gene
Gene Families for B3GNT8 Gene
Protein Domains for B3GNT8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for B3GNT8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z7M8- Family:
-
- Belongs to the glycosyltransferase 31 family.
Function for B3GNT8 Gene
Molecular function for B3GNT8 Gene
- UniProtKB/Swiss-Prot Function:
- Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in colon cancer.
Enzyme Numbers (IUBMB) for B3GNT8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008378 | galactosyltransferase activity | IEA | -- |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | TAS | -- |
| GO:0016262 | protein N-acetylglucosaminyltransferase activity | IDA | 15620693 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for B3GNT8 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for B3GNT8 gene
-
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- Search ViGene Biosciences for B3GNT8
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT8
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT8
- GenScript: Design CRISPR guide RNA sequences for B3GNT8
miRNA for B3GNT8 Gene
- miRTarBase miRNAs that target B3GNT8
miRNA Products
- Search ViGene Biosciences for B3GNT8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for B3GNT8
- Browse OriGene Inhibitory RNA Products For B3GNT8
-
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Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for B3GNT8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for B3GNT8
-
ViGene Biosciences adenoviral particle packaged cDNA for B3GNT8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for B3GNT8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for B3GNT8 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT8 Gene
Localization for B3GNT8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for B3GNT8 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23533145 |
Pathways & Interactions for B3GNT8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | O-linked glycosylation | ||
Pathways by source for B3GNT8 Gene
4 Reactome pathways for B3GNT8 Gene
UniProtKB/Swiss-Prot Q7Z7M8-B3GN8_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for B3GNT8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0030311 | poly-N-acetyllactosamine biosynthetic process | IDA | 15620693 |
No data available for SIGNOR curated interactions for B3GNT8 Gene
Drugs & Compounds for B3GNT8 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Poly-N-acetyllactosamine |
|
82441-98-3 |
|
Transcripts for B3GNT8 Gene
mRNA/cDNA for B3GNT8 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (19) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for B3GNT8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT8
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT8
- GenScript: Design CRISPR guide RNA sequences for B3GNT8
miRNA Products
- Search ViGene Biosciences for B3GNT8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for B3GNT8
- Browse OriGene Inhibitory RNA Products For B3GNT8
-
ViGene Biosciences ready-to-package AAV shRNAs for B3GNT8 gene
Clone Products
-
OriGene ORF clones in human for B3GNT8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for B3GNT8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Expression for B3GNT8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Conventional Dendritic Cells II Spleen
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Nucleus Pulposus
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- Spleen (Hematopoietic System)
- Primitive Streak (Early Embryonic Tissues)
-
Peripheral Nervous System (Nervous System)
mRNA differential expression in normal tissues according to GTEx for B3GNT8 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GNT8 Gene
NURSA nuclear receptor signaling pathways regulating expression of B3GNT8 Gene:
B3GNT8SOURCE GeneReport for Unigene cluster for B3GNT8 Gene:
Hs.441681mRNA Expression by UniProt/SwissProt for B3GNT8 Gene:
Q7Z7M8-B3GN8_HUMANPrimer Products
-
OriGene qPCR primer pairs for B3GNT8
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT8 Gene
Orthologs for B3GNT8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | B3GNT8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | B3GNT8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | B3GNT8 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | B3gnt8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | B3gnt8 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | B3GNT8 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | B3GNT8 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | b3gnt2l 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.163 35 |
|
OneToMany |
- Species where no ortholog for B3GNT8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for B3GNT8 Gene
Paralogs for B3GNT8 Gene
(6) SIMAP similar genes for B3GNT8 Gene using alignment to 1 proteins:
Variants for B3GNT8 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10421626 | Likely benign | 41,424,917(+) | TGGAC(A/G)TGGCA | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs528816040 | Uncertain significance | 41,424,942(+) | ACTTG(C/T)GCAGG | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs564517344 | Uncertain significance | 41,424,932(+) | AGCCT(A/G)TGGAA | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs886054463 | Uncertain significance | 41,424,943(+) | CTTGC(A/G)CAGGT | downstream-variant-500B, utr-variant-3-prime | |
| rs886054464 | Uncertain significance | 41,424,973(+) | CACGA(A/G)TAAAC | downstream-variant-500B, utr-variant-3-prime |
Relevant External Links for B3GNT8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- B3GNT8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT8 Gene
Disorders for B3GNT8 Gene
Relevant External Links for B3GNT8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- B3GNT8
No disorders were found for B3GNT8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT8 Gene
Publications for B3GNT8 Gene
- A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. (PMID: 15620693) Ishida H. … Narimatsu H. (FEBS Lett. 2005) 3 4 22 64
- Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family. (PMID: 15486459) Huang C. … Yu L. (Glycoconj. J. 2004) 2 3 4 64
- Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. (PMID: 18826941) Seko A. … Yamashita K. (J. Biol. Chem. 2008) 3 4 64
- Transcription factor c-jun regulates I^3Gn-T8 expression in gastric cancer cell line SGC-7901. (PMID: 27459970) Jiang Z. … Wu S. (Oncol. Rep. 2016) 3 64
- I^3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147. (PMID: 24573103) Ni J. … Wu S. (Oncol. Rep. 2014) 3 64
Products for B3GNT8 Gene
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- OriGene qPCR primer pairs for B3GNT8
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- Novus Biologicals Antibodies for B3GNT8
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- Horizon Cell Lines for B3GNT8
- Cyagen custom Knockout/knockin (KOKI) mouse models for B3GNT8
- VectorBuilder custom plasmid, inducible vectors for B3GNT8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for B3GNT8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




