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Aliases for B3GNT7 Gene

Aliases for B3GNT7 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7 2 3 5
  • Beta-1,3-Gn-T7 3 4
  • Beta3Gn-T7 3 4
  • BGnT-7 3 4
  • Beta 1,3-N-Acetylglucosaminyltransferase 7 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 7 4
  • EC 2.4.1.- 4
  • Beta3GnT7 3
  • EC 2.4.1 61

External Ids for B3GNT7 Gene

Previous GeneCards Identifiers for B3GNT7 Gene

  • GC02P230320
  • GC02P230992
  • GC02P232225
  • GC02P232462
  • GC02P232085
  • GC02P231968
  • GC02P232260
  • GC02P224101

Summaries for B3GNT7 Gene

GeneCards Summary for B3GNT7 Gene

B3GNT7 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and O-linked glycosylation. GO annotations related to this gene include transferase activity, transferring glycosyl groups and galactosyltransferase activity. An important paralog of this gene is B3GNT9.

UniProtKB/Swiss-Prot for B3GNT7 Gene

  • May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT7 Gene

Genomics for B3GNT7 Gene

Regulatory Elements for B3GNT7 Gene

Enhancers for B3GNT7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G231407 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.4 +15.9 15906 9.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 CBX5 B3GNT7 ARMC9 ENSG00000233538 SNORA75 SNORD20 HTR2B NCL RNU2-22P PSMD1 ENSG00000224376
GH02G231390 1.4 FANTOM5 ENCODE dbSUPER 15.3 -2.3 -2323 5.0 ELF3 HDGF TBP TBL1XR1 WRNIP1 SIN3A RAD21 GATA2 ELK1 ZNF207 B3GNT7 NMUR1 ENSG00000224376 PTMA PIR50605
GH02G231399 1.3 Ensembl ENCODE dbSUPER 16.3 +4.7 4746 2.2 HDGF CTCF NFIB TAL1 ZNF384 RAD21 ZIC2 RARA TEAD3 TCF12 B3GNT7 LOC105373926
GH02G231387 1.2 Ensembl ENCODE dbSUPER 13.5 -6.9 -6860 1.4 CTCF SAP130 RNF2 ARID4B ZNF48 ZGPAT MXD3 GABPB1 MBD1 ZNF580 B3GNT7 ENSG00000224376 PIR53220
GH02G231425 0.9 ENCODE dbSUPER 13.7 +30.9 30861 2.1 MAX EBF1 DPF2 RARA CTBP1 GATA3 JUND SCRT2 IKZF1 FOS B3GNT7 ENSG00000233538 SNORA75 SNORD20 ARMC9 NCL RNU2-22P HTR2B PSMD1 ZBTB8OSP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B3GNT7 on UCSC Golden Path with GeneCards custom track

Promoters for B3GNT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000131820 357 1001 STAT1 BACH1 GATAD2B DPF2 NR2F2 GATA2 POLR2A FOS ZNF652 EZH2

Genomic Location for B3GNT7 Gene

Chromosome:
2
Start:
231,395,543 bp from pter
End:
231,408,801 bp from pter
Size:
13,259 bases
Orientation:
Plus strand

Genomic View for B3GNT7 Gene

Genes around B3GNT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT7 Gene

Proteins for B3GNT7 Gene

  • Protein details for B3GNT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFL0-B3GN7_HUMAN
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
    Protein Accession:
    Q8NFL0
    Secondary Accessions:
    • B3KWY4
    • B7WNP0

    Protein attributes for B3GNT7 Gene

    Size:
    401 amino acids
    Molecular mass:
    45987 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GNT7 Gene

Selected DME Specific Peptides for B3GNT7 Gene

Q8NFL0:
  • AIRQTWG
  • PIDDVFLGMCL

Post-translational modifications for B3GNT7 Gene

  • Glycosylation at posLast=8888, posLast=9494, Asn214, and posLast=391391
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for B3GNT7 Gene

Gene Families for B3GNT7 Gene

Protein Domains for B3GNT7 Gene

Suggested Antigen Peptide Sequences for B3GNT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFL0

UniProtKB/Swiss-Prot:

B3GN7_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT7: view

Function for B3GNT7 Gene

Molecular function for B3GNT7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.

Enzyme Numbers (IUBMB) for B3GNT7 Gene

Gene Ontology (GO) - Molecular Function for B3GNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS --
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GNT7: view
genes like me logo Genes that share phenotypes with B3GNT7: view

Animal Models for B3GNT7 Gene

MGI Knock Outs for B3GNT7:

Animal Model Products

  • Taconic Biosciences Mouse Models for B3GNT7

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GNT7 Gene

Localization for B3GNT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B3GNT7 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for B3GNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT7: view

Pathways & Interactions for B3GNT7 Gene

genes like me logo Genes that share pathways with B3GNT7: view

UniProtKB/Swiss-Prot Q8NFL0-B3GN7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT7 Gene

Gene Ontology (GO) - Biological Process for B3GNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with B3GNT7: view

No data available for SIGNOR curated interactions for B3GNT7 Gene

Drugs & Compounds for B3GNT7 Gene

(2) Additional Compounds for B3GNT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
69992-87-6
N-Acetylgalactosamine
  • 2-Acetamido-2-deoxy-a-D-allopyranose
  • 2-Acetamido-2-deoxy-a-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-D-allopyranose
  • 2-Acetamido-2-deoxy-alpha-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-delta-allopyranose
1811-31-0
genes like me logo Genes that share compounds with B3GNT7: view

Transcripts for B3GNT7 Gene

mRNA/cDNA for B3GNT7 Gene

Unigene Clusters for B3GNT7 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT7 Gene

No ASD Table

Relevant External Links for B3GNT7 Gene

GeneLoc Exon Structure for
B3GNT7
ECgene alternative splicing isoforms for
B3GNT7

Expression for B3GNT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B3GNT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT7 Gene

This gene is overexpressed in Colon - Transverse (x7.6).

Protein differential expression in normal tissues from HIPED for B3GNT7 Gene

This gene is overexpressed in Islet of Langerhans (48.3) and Rectum (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for B3GNT7 Gene



Protein tissue co-expression partners for B3GNT7 Gene

NURSA nuclear receptor signaling pathways regulating expression of B3GNT7 Gene:

B3GNT7

SOURCE GeneReport for Unigene cluster for B3GNT7 Gene:

Hs.299329
genes like me logo Genes that share expression patterns with B3GNT7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT7 Gene

Orthologs for B3GNT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT7 34
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia B3GNT7 34 35
  • 89.28 (n)
cow
(Bos Taurus)
Mammalia B3GNT7 34 35
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia B3gnt7 34 16 35
  • 82.45 (n)
rat
(Rattus norvegicus)
Mammalia B3gnt7 34
  • 82.28 (n)
oppossum
(Monodelphis domestica)
Mammalia B3GNT7 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT7 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GNT7 34 35
  • 69.46 (n)
lizard
(Anolis carolinensis)
Reptilia B3GNT7 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt7 34
  • 58.44 (n)
Str.1901 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2079 34
zebrafish
(Danio rerio)
Actinopterygii b3gnt7 34 35
  • 64.5 (n)
Species where no ortholog for B3GNT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT7 Gene

ENSEMBL:
Gene Tree for B3GNT7 (if available)
TreeFam:
Gene Tree for B3GNT7 (if available)

Paralogs for B3GNT7 Gene

(10) SIMAP similar genes for B3GNT7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT7: view

Variants for B3GNT7 Gene

Sequence variations from dbSNP and Humsavar for B3GNT7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000538956 -- 231,400,627(+) AGCCA(A/G)CCAGC upstream-variant-2KB, utr-variant-3-prime
rs1000687449 -- 231,394,262(+) TAATT(C/G)GCACT upstream-variant-2KB, utr-variant-3-prime
rs1000763936 -- 231,400,915(+) AAAAC(A/G/T)ACTGG upstream-variant-2KB, utr-variant-3-prime
rs1000831213 -- 231,399,628(+) CAGAA(A/G)AGCAG upstream-variant-2KB, utr-variant-3-prime
rs1000865922 -- 231,395,626(+) AAGGG(A/G)TTAAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for B3GNT7 Gene

Variant ID Type Subtype PubMed ID
esv3594622 CNV gain 21293372
nsv834566 CNV loss 17160897
nsv834567 CNV gain 17160897

Variation tolerance for B3GNT7 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GNT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
B3GNT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT7 Gene

Disorders for B3GNT7 Gene

Relevant External Links for B3GNT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT7

No disorders were found for B3GNT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT7 Gene

Publications for B3GNT7 Gene

  1. A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. (PMID: 12061784) Kataoka K. … Huh N.-H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Beta1,3-N-acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans. (PMID: 14706853) Seko A. … Yamashita K. (FEBS Lett. 2004) 3 4 64
  4. Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. (PMID: 24418929) Lu C.H. … Yu L.C. (Glycobiology 2014) 3 64
  5. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3 64

Products for B3GNT7 Gene

Sources for B3GNT7 Gene

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