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Aliases for B3GNT7 Gene

Aliases for B3GNT7 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7 2 3 5
  • Beta-1,3-N-Acetylglucosaminyltransferase 7 3 4
  • Beta-1,3-Gn-T7 3 4
  • Beta3Gn-T7 3 4
  • BGnT-7 3 4
  • Beta 1,3-N-Acetylglucosaminyltransferase 7 3
  • EC 2.4.1.- 4
  • Beta3GnT7 3
  • EC 2.4.1 63

External Ids for B3GNT7 Gene

Previous GeneCards Identifiers for B3GNT7 Gene

  • GC02P230320
  • GC02P230992
  • GC02P232225
  • GC02P232462
  • GC02P232085
  • GC02P231968
  • GC02P232260
  • GC02P224101

Summaries for B3GNT7 Gene

GeneCards Summary for B3GNT7 Gene

B3GNT7 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Keratan sulfate/keratin metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT7 Gene

  • May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT7 Gene

Genomics for B3GNT7 Gene

Regulatory Elements for B3GNT7 Gene

Enhancers for B3GNT7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B3GNT7 on UCSC Golden Path with GeneCards custom track

Promoters for B3GNT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B3GNT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GNT7 Gene

Chromosome:
2
Start:
231,395,543 bp from pter
End:
231,408,801 bp from pter
Size:
13,259 bases
Orientation:
Plus strand

Genomic View for B3GNT7 Gene

Genes around B3GNT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT7 Gene

Proteins for B3GNT7 Gene

  • Protein details for B3GNT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFL0-B3GN7_HUMAN
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
    Protein Accession:
    Q8NFL0
    Secondary Accessions:
    • B3KWY4
    • B7WNP0

    Protein attributes for B3GNT7 Gene

    Size:
    401 amino acids
    Molecular mass:
    45987 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GNT7 Gene

Proteomics data for B3GNT7 Gene at MOPED

Selected DME Specific Peptides for B3GNT7 Gene

Post-translational modifications for B3GNT7 Gene

  • Glycosylation at Asn 88, Asn 94, Asn 214, and Asn 391
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for B3GNT7 Gene

Gene Families for B3GNT7 Gene

Protein Domains for B3GNT7 Gene

Suggested Antigen Peptide Sequences for B3GNT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFL0

UniProtKB/Swiss-Prot:

B3GN7_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT7: view

Function for B3GNT7 Gene

Molecular function for B3GNT7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.

Enzyme Numbers (IUBMB) for B3GNT7 Gene

genes like me logo Genes that share phenotypes with B3GNT7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for B3GNT7

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT7 Gene

Localization for B3GNT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GNT7 Gene COMPARTMENTS Subcellular localization image for B3GNT7 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for B3GNT7 Gene

Pathways & Interactions for B3GNT7 Gene

genes like me logo Genes that share pathways with B3GNT7: view

UniProtKB/Swiss-Prot Q8NFL0-B3GN7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT7 Gene

Gene Ontology (GO) - Biological Process for B3GNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0042339 keratan sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with B3GNT7: view

No data available for SIGNOR curated interactions for B3GNT7 Gene

Drugs & Compounds for B3GNT7 Gene

(2) Additional Compounds for B3GNT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
69992-87-6
N-Acetylgalactosamine
  • 2-Acetamido-2-deoxy-a-D-allopyranose
  • 2-Acetamido-2-deoxy-a-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-D-allopyranose
  • 2-Acetamido-2-deoxy-alpha-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-delta-allopyranose
1811-31-0
genes like me logo Genes that share compounds with B3GNT7: view

Transcripts for B3GNT7 Gene

mRNA/cDNA for B3GNT7 Gene

Unigene Clusters for B3GNT7 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT7 Gene

No ASD Table

Relevant External Links for B3GNT7 Gene

GeneLoc Exon Structure for
B3GNT7
ECgene alternative splicing isoforms for
B3GNT7

Expression for B3GNT7 Gene

mRNA expression in normal human tissues for B3GNT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT7 Gene

This gene is overexpressed in Colon - Transverse (x7.6).

Protein differential expression in normal tissues from HIPED for B3GNT7 Gene

This gene is overexpressed in Islet of Langerhans (48.3) and Rectum (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for B3GNT7 Gene



SOURCE GeneReport for Unigene cluster for B3GNT7 Gene Hs.299329

genes like me logo Genes that share expression patterns with B3GNT7: view

Protein tissue co-expression partners for B3GNT7 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for B3GNT7 Gene

Orthologs for B3GNT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GNT7 35
  • 85.54 (n)
  • 84.29 (a)
B3GNT7 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GNT7 35
  • 89.28 (n)
  • 89.28 (a)
B3GNT7 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3gnt7 35
  • 82.45 (n)
  • 86.15 (a)
B3gnt7 16
B3gnt7 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B3GNT7 35
  • 98.87 (n)
  • 98.69 (a)
rat
(Rattus norvegicus)
Mammalia B3gnt7 35
  • 82.28 (n)
  • 85.64 (a)
oppossum
(Monodelphis domestica)
Mammalia B3GNT7 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT7 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GNT7 35
  • 69.46 (n)
  • 68.27 (a)
B3GNT7 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B3GNT7 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt7 35
  • 58.44 (n)
  • 61.21 (a)
Str.1901 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2079 35
zebrafish
(Danio rerio)
Actinopterygii b3gnt7 35
  • 64.5 (n)
  • 61.95 (a)
b3gnt7 36
  • 53 (a)
OneToOne
Species with no ortholog for B3GNT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT7 Gene

ENSEMBL:
Gene Tree for B3GNT7 (if available)
TreeFam:
Gene Tree for B3GNT7 (if available)

Paralogs for B3GNT7 Gene

(10) SIMAP similar genes for B3GNT7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT7: view

Variants for B3GNT7 Gene

Sequence variations from dbSNP and Humsavar for B3GNT7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2290130 - 231,398,416(-) GGGGA(C/T)GTGGG nc-transcript-variant, reference, missense
rs4972989 -- 231,395,826(+) GGGGC(G/T)GGGGG intron-variant, upstream-variant-2KB
rs6750321 -- 231,397,077(+) TCAAC(A/C)ATGAG intron-variant, upstream-variant-2KB
rs10445829 -- 231,397,708(+) CCTCT(A/G)TACTG intron-variant
rs10445830 -- 231,399,262(+) AGGAA(C/T)GCTGT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for B3GNT7 Gene

Variant ID Type Subtype PubMed ID
nsv834566 CNV Loss 17160897
dgv4446n71 CNV Loss 21882294
nsv834567 CNV Gain 17160897
dgv4447n71 CNV Loss 21882294
nsv875965 CNV Gain 21882294

Variation tolerance for B3GNT7 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for B3GNT7 Gene

Disorders for B3GNT7 Gene

Relevant External Links for B3GNT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT7

No disorders were found for B3GNT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT7 Gene

Publications for B3GNT7 Gene

  1. A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. (PMID: 12061784) Kataoka K. … Huh N.-H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. (PMID: 24418929) Lu C.H. … Yu L.C. (Glycobiology 2014) 3
  3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3
  4. Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. (PMID: 17690104) Kitayama K. … Akama T.O. (J. Biol. Chem. 2007) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for B3GNT7 Gene

Sources for B3GNT7 Gene

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