B3GNT7 Gene
protein-coding GIFtS: 48
GCID: GC02P232260
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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase...
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Aliases
for B3GNT7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 71 2 | | Beta3Gn-T73 | | Beta3GnT71 | | Beta-1,3-Gn-T73 | | Beta-1,3-N-Acetylglucosaminyltransferase 72 3 | | Beta3Gn-T73 | | BGnT-72 3 | | EC 2.4.1.-3 | | Beta 1,3-N-Acetylglucosaminyltransferase 72 | | EC 2.4.18 | | Beta-1,3-Gn-T73 | | |
Export aliases for B3GNT7 gene to outside databasesPrevious GC identifers: GC02P230320 GC02P230992 GC02P232225 GC02P232462 GC02P232085 GC02P231968 GC02P224101 |
Summaries
for B3GNT7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: B3GN7_HUMAN, Q8NFL0Function: May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratansulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invadingsurrounding tissues
|
Genomic Views
for B3GNT7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the B3GNT7 gene promoter:
Elk-1 AML1a MyoD Olf-1 Lmo2 AP-4 AREB6 N-Myc MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for B3GNT7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GNT7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q36.1B3GNT7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P232260: view genomic region
(about GC identifiers)
Start:
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232,260,254 bp from pter |
End:
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232,265,875 bp from pter |
Size:
|
5,622 bases |
Orientation:
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plus strand |
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Proteins
for B3GNT7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: B3GN7_HUMAN, Q8NFL0 (See
protein sequence)Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Size: 401 amino acids; 45987 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: B3KWY4 B7WNP0Explore the universe of human proteins at neXtProt for B3GNT7: NX_Q8NFL0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NFL0
2 DME Specific Peptides for B3GNT7 (Q8NFL0)
B3GNT7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660279.1
ENSEMBL proteins: ENSP00000287590 Reactome Protein details: Q8NFL0
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
B3GNT7 for ontologies About GeneDecksing
B3GNT7 Antibody Products:
Assay Products for B3GNT7: |
Protein
Domains /
Families
for B3GNT7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
B3GNT7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NFL0ProtoNet protein and cluster: Q8NFL0 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GN7_HUMAN, Q8NFL0Similarity: Belongs to the glycosyltransferase 31 family |
Function
for B3GNT7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: B3GN7_HUMAN, Q8NFL0Function: May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratansulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invadingsurrounding tissuesEnzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: B3GNT7 (NM_145236) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for B3GNT7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008378 | galactosyltransferase activity |
IEA | -- |
B3GNT7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for B3GNT7:
|
Pathways & Interactions
for B3GNT7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MPS IIIC - Sanfilippo syndrome C | | | 2 | Keratan sulfate biosynthesis | | | 3 | Asparagine N-linked glycosylation | | | 4 | Disease | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/21 
Reactome Pathways for B3GNT7 (see all 21)
1 
Kegg Pathway (Kegg details for B3GNT7):
UniProtKB/Swiss-Prot: B3GN7_HUMAN, Q8NFL0Pathway: Protein modification; protein glycosylation
B3GNT7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GNT7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for B3GNT7 (ENSP000002875904) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0016266 | O-glycan processing |
TAS | -- | | GO:0018146 | keratan sulfate biosynthetic process |
TAS | -- | | GO:0030203 | glycosaminoglycan metabolic process |
TAS | -- | | GO:0042339 | keratan sulfate metabolic process |
TAS | -- |
B3GNT7 for ontologies About GeneDecksing
|
Drugs & Compounds
for B3GNT7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for B3GNT7
2 HMDB Compounds for B3GNT7 About this table
Search CenterWatch for drugs/clinical trials and news about B3GNT7 / B3GN7
|
Transcripts
for B3GNT7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for B3GNT7 gene: NM_145236.2 Unigene Cluster for B3GNT7: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Hs.299329 [show with all ESTs]Unigene Representative Sequence: NM_1452362 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287590(uc002vrs.3) ENST00000479618
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: B3GNT7 (NM_145236) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for B3GNT7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT7 |
Additional cDNA sequence: AF502430.1 AK000770.1 AK126207.1 2 DOTS entries: DT.95182937 DT.121035174 24/41 AceView cDNA sequences (see all 41): NM_145236 AW591607 CR626252 AF502430 AK126207 AA669325 CA310615 CA314028 CA310256 AK000770 AW468484 AA568650 AW963021 BG830051 CA312028 CA310801 BX642147 AA296727 BQ705935 BQ448611 BG832264 BQ962194 CA314634 BU686873
GeneLoc Exon Structure
|
Expression
for B3GNT7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| B3GNT7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTGGAGG
About this image
See B3GNT7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for B3GNT7
SOURCE GeneReport for Unigene cluster: Hs.299329
SABiosciences Custom PCR Arrays for B3GNT7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GNT7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B3GNT7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GNT7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GNT7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT7 |
Orthologs
for B3GNT7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for B3GNT7 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for B3GNT7 (if available)
TreeFam Gene Tree for B3GNT7 (if available) |
Paralogs
for B3GNT7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for B3GNT7 gene
- B3GNT32 B3GNT22 B3GNT52 B3GALT52 B3GALT12 B3GNT42 B3GALT42 B3GALT22
- B3GNT82 B3GNT62 B3GALNT12 B3GNT92
11 SIMAP similar genes for B3GNT7 using alignment to 1 protein entry: B3GN7_HUMAN:B3GNT3 B3GNT2 B3GNT5 B3GNT9 B3GNT4 B3GNT6
B3GALT1 B3GALNT1 B3GALT2 B3GALT5 B3GNT8
B3GNT7 for paralogs About GeneDecksing
|
Genomic Variants
for B3GNT7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for B3GNT7 (232260254 - 232265875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for B3GNT7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GNT7 |
|
Disorders
/ Diseases
for B3GNT7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for B3GNT7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for B3GNT7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with B3GNT7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. (PubMed id 12061784)1, 2, 3 Kataoka K. and Huh N.-H. (2002)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Beta1,3-N-acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans. (PubMed id 14706853)1, 2 Seko A. and Yamashita K. (2004)
- Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. (PubMed id 17690104)1 Kitayama K....Akama T.O. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for B3GNT7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing B3GNT7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing B3GNT7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GNT7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for B3GNT7 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT7 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_562 |
|
| | |
About This Section
| Patent Information for B3GNT7 gene:
Search GeneIP for patents involving B3GNT7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for B3GNT7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for B3GNT7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GNT7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GNT7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for B3GNT7 | | OriGene 3'-UTR Clone for B3GNT7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat B3GNT7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GNT7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GNT7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GNT7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GNT7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GNT7 |
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 |  |  |  | |
| | | | Search Tocris compounds for B3GNT7 |
| |  |  |  |  | | | | |
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 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT7 |
|  |  |  | | | | ThermoFisher Antibodies for B3GNT7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT7 |
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