Aliases for B3GNT7 Gene
Aliases for B3GNT7 Gene
External Ids for B3GNT7 Gene
- HGNC: 18811
- Entrez Gene: 93010
- Ensembl: ENSG00000156966
- OMIM: 615313
- UniProtKB: Q8NFL0
Previous GeneCards Identifiers for B3GNT7 Gene
- GC02P230320
- GC02P230992
- GC02P232225
- GC02P232462
- GC02P232085
- GC02P231968
- GC02P232260
- GC02P224101
Summaries for B3GNT7 Gene
GeneCards Summary for B3GNT7 Gene
B3GNT7 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and O-linked glycosylation. GO annotations related to this gene include transferase activity, transferring glycosyl groups and galactosyltransferase activity. An important paralog of this gene is B3GNT9.
UniProtKB/Swiss-Prot for B3GNT7 Gene
-
May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT7 Gene
Genomics for B3GNT7 Gene
Regulatory Elements for B3GNT7 Gene
Regulatory Element Products
Genomic Location for B3GNT7 Gene
- Chromosome:
- 2
- Start:
- 231,395,543 bp from pter
- End:
- 231,408,801 bp from pter
- Size:
- 13,259 bases
- Orientation:
- Plus strand
Genomic View for B3GNT7 Gene
- Cytogenetic band:
-
- 2q37.1 by Ensembl
- 2q37.1|2q37.1 by Entrez Gene
- 2q37.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for B3GNT7 Gene
Proteins for B3GNT7 Gene
-
Protein details for B3GNT7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFL0-B3GN7_HUMAN
- Recommended name:
- UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
- Protein Accession:
- Q8NFL0
- B3KWY4
- B7WNP0
Protein attributes for B3GNT7 Gene
- Size:
- 401 amino acids
- Molecular mass:
- 45987 Da
- Quaternary structure:
- No Data Available
Protein Expression for B3GNT7 Gene
Selected DME Specific Peptides for B3GNT7 Gene
- Q8NFL0:
-
- AIRQTWG
- PIDDVFLGMCL
Post-translational modifications for B3GNT7 Gene
Other Protein References for B3GNT7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for B3GNT7
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-
Abcam antibodies for B3GNT7
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- antibodies-online Antibodies for B3GNT7: See all 25
- GeneTex B3GNT7 antibody for B3GNT7
-
Santa Cruz Biotechnology (SCBT) Antibodies for B3GNT7
Protein Products
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-
Abcam proteins for B3GNT7
Assay Products
Domains & Families for B3GNT7 Gene
Gene Families for B3GNT7 Gene
Protein Domains for B3GNT7 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for B3GNT7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NFL0- Family:
-
- Belongs to the glycosyltransferase 31 family.
Function for B3GNT7 Gene
Molecular function for B3GNT7 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.
Enzyme Numbers (IUBMB) for B3GNT7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008378 | galactosyltransferase activity | IEA | -- |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | TAS | -- |
| GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for B3GNT7 Gene
- MGI mutant phenotypes for B3GNT7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for B3GNT7:
Animal Models for B3GNT7 Gene
- MGI Knock Outs for B3GNT7:
-
- B3gnt7 tm1e.1(KOMP)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for B3GNT7
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-
-
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-
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CRISPR Products
-
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-
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miRNA for B3GNT7 Gene
- miRTarBase miRNAs that target B3GNT7
-
- hsa-mir-4668-5p (MIRT637765)
- hsa-mir-3613-3p (MIRT637766)
- hsa-mir-5588-3p (MIRT637767)
- hsa-mir-6507-3p (MIRT637768)
- hsa-mir-7856-5p (MIRT660382)
- hsa-mir-384 (MIRT660383)
- hsa-mir-3658 (MIRT660384)
- hsa-mir-7975 (MIRT660385)
- hsa-mir-5571-3p (MIRT660386)
- hsa-mir-6832-3p (MIRT660387)
- hsa-mir-129-2-3p (MIRT660388)
- hsa-mir-129-1-3p (MIRT660389)
- hsa-mir-6779-3p (MIRT660390)
- hsa-mir-4687-5p (MIRT660391)
- hsa-mir-4461 (MIRT660392)
miRNA Products
- Search ViGene Biosciences for B3GNT7
Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for B3GNT7
-
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-
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-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GNT7 Gene
Localization for B3GNT7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for B3GNT7 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for B3GNT7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratan sulfate/keratin metabolism | ||
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Metabolism of proteins | ||
| 4 | O-linked glycosylation | ||
| 5 | Metabolism |
.37
|
|
Pathways by source for B3GNT7 Gene
9 Reactome pathways for B3GNT7 Gene
1 KEGG pathway for B3GNT7 Gene
UniProtKB/Swiss-Prot Q8NFL0-B3GN7_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for B3GNT7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0018146 | keratan sulfate biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for B3GNT7 Gene
Drugs & Compounds for B3GNT7 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Keratan |
|
69992-87-6 |
|
|||
| N-Acetylgalactosamine |
|
1811-31-0 |
|
Transcripts for B3GNT7 Gene
mRNA/cDNA for B3GNT7 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (41) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for B3GNT7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT7
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT7
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miRNA Products
- Search ViGene Biosciences for B3GNT7
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for B3GNT7
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-
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for B3GNT7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for B3GNT7 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for B3GNT7 Gene
NURSA nuclear receptor signaling pathways regulating expression of B3GNT7 Gene:
B3GNT7SOURCE GeneReport for Unigene cluster for B3GNT7 Gene:
Hs.299329Primer Products
-
OriGene qPCR primer pairs for B3GNT7
-
OriGene qPCR primer pairs and template standards for B3GNT7
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT7 Gene
Orthologs for B3GNT7 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | B3GNT7 34 |
|
||
| dog (Canis familiaris) |
Mammalia | B3GNT7 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | B3GNT7 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | B3gnt7 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | B3gnt7 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | B3GNT7 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | B3GNT7 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | B3GNT7 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | B3GNT7 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | b3gnt7 34 |
|
||
| Str.1901 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2079 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | b3gnt7 34 35 |
|
- Species where no ortholog for B3GNT7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for B3GNT7 Gene
Paralogs for B3GNT7 Gene
(10) SIMAP similar genes for B3GNT7 Gene using alignment to 1 proteins:
Variants for B3GNT7 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000538956 | -- | 231,400,627(+) | AGCCA(A/G)CCAGC | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000687449 | -- | 231,394,262(+) | TAATT(C/G)GCACT | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000763936 | -- | 231,400,915(+) | AAAAC(A/G/T)ACTGG | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000831213 | -- | 231,399,628(+) | CAGAA(A/G)AGCAG | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000865922 | -- | 231,395,626(+) | AAGGG(A/G)TTAAG | upstream-variant-2KB, utr-variant-5-prime |
Relevant External Links for B3GNT7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- B3GNT7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT7 Gene
Disorders for B3GNT7 Gene
Relevant External Links for B3GNT7
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- B3GNT7
No disorders were found for B3GNT7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT7 Gene
Publications for B3GNT7 Gene
- A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro. (PMID: 12061784) Kataoka K. … Huh N.-H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
- Beta1,3-N-acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans. (PMID: 14706853) Seko A. … Yamashita K. (FEBS Lett. 2004) 3 4 64
- Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells. (PMID: 24418929) Lu C.H. … Yu L.C. (Glycobiology 2014) 3 64
- Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3 64
Products for B3GNT7 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for B3GNT7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
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- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
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- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




