B3GNT6 Gene
protein-coding GIFtS: 47
GCID: GC11P076745
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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase...
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Aliases for B3GNT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6 (Core 3Synthase)1 2 | | Beta-1,3-N-Acetylglucosaminyltransferase Protein2 | | B3Gn-T61 2 | | Beta3Gn-T63 | | Beta-1,3-N-Acetylglucosaminyltransferase 62 3 | | UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 62 | | Core 3 Synthase2 3 | | Beta-1,3-Gn-T63 | | BGnT-62 3 | | Beta3Gn-T63 | | IMAGE:49070982 | | EC 2.4.1.-3 | | Beta-1,3-Gn-T63 | | |
Export aliases for B3GNT6 gene to outside databasesPrevious GC identifers: GC11M068646 GC11M067794 GC11M066362 GC11M065889 GC11M065890 GC11M065869 GC11P076425 GC11P073043 |
Summaries for B3GNT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an importantprecursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-typeO-glycans in digestive organs
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Genomic Views for B3GNT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the B3GNT6 gene promoter: NF-1 NF-1/L CUTL1 XBP-1 AP-4 PPAR-gamma1 E2F-1 E2F PPAR-gamma2 ATF6 Other transcription factors
Search SABiosciences Chromatin IP Primers for B3GNT6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GNT6 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.4B3GNT6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P076745: view genomic region
(about GC identifiers)
Start:
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76,745,385 bp from pter |
End:
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76,753,096 bp from pter |
Size:
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7,712 bases |
Orientation:
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plus strand |
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Proteins for B3GNT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0 (See
protein sequence)Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 Size: 384 amino acids; 42748 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Miscellaneous: Injection into nude mice significantly suppress lung metastasis, indicating that the core structures ofO-glycans are profoundly involved in the metastatic capacity of cancer cells
Secondary accessions: Q6ZSC5 Q8TAZ4 Q8TDX1Alternative splicing: 2 isoforms: Q6ZMB0-1 Q6ZMB0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for B3GNT6: NX_Q6ZMB0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZMB0 B3GNT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_619651.3 ENSEMBL proteins: ENSP00000435352 ENSP00000435628 ENSP00000346256 ENSP00000403463 Reactome Protein details: Q6ZMB0 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
B3GNT6 for ontologies About GeneDecksing
B3GNT6 Antibody Products: Assay Products for B3GNT6: |
Protein
Domains / Families for B3GNT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
B3GNT6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZMB0ProtoNet protein and cluster: Q6ZMB0 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Similarity: Belongs to the glycosyltransferase 31 family |
Function for B3GNT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an importantprecursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-typeO-glycans in digestive organsInduction: Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker fordistinguishing between benign adenomas and premalignant lesions (at protein level)Enzyme Number (IUBMB): EC 2.4.1.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT6 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: B3GNT6 (NM_138706) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for B3GNT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT6  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008378 | galactosyltransferase activity |
IDA | 11821425 | | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity |
NAS | 11821425 |
B3GNT6 for ontologies About GeneDecksing
Animal Models: 10 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for B3gnt6):
B3GNT6 for phenotypes About GeneDecksing
|
Pathways & Interactions for B3GNT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | | | 2 | Asparagine N-linked glycosylation | | | 3 | Metabolism | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Reactome Pathways for B3GNT6
2
Kegg Pathways (Kegg details for B3GNT6): UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Pathway: Protein modification; protein glycosylation
B3GNT6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GNT6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
 5/24 Interacting proteins for B3GNT6 (ENSP000003462564) via UniProtKB, MINT, STRING, and/or I2D (see all 24) About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
B3GNT6 for ontologies About GeneDecksing
|
Drugs & Compounds for B3GNT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for B3GNT6 Search CenterWatch for drugs/clinical trials and news about B3GNT6 / B3GN6 
|
Transcripts for B3GNT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for B3GNT6 gene: NM_138706.3 Unigene Cluster for B3GNT6: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase) Hs.352622 [show with all ESTs]Unigene Representative Sequence: NM_1387064 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533140(uc021qnp.1) ENST00000528622 ENST00000354301 ENST00000421061
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GNT6 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: B3GNT6 (NM_138706) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for B3GNT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT6  |
Additional cDNA sequence: AB073740.1 AK127544.1 AK172863.1 AK292773.1 AK313682.1 BC025357.1 BC103908.1 BC103909.2 BC103910.1 2 DOTS entries: DT.75195592 DT.101975582 19 AceView cDNA sequences: NM_138706 AW192172 BC025357 BX480039 AK172863 AB073740 CD636502 AK127544 CD636501 CD636508 CD636506 CD636507 BX477104 CD636505 CD636503 AW182889 BP383116 CD636499 CD636500 GeneLoc Exon Structure
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Expression for B3GNT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| B3GNT6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See B3GNT6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for B3GNT6
SOURCE GeneReport for Unigene cluster: Hs.352622 UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Tissue specificity: Present in stomach and colon (at protein level). Restricted in the stomach, colon and smallintestine, where core 3 structure is present SABiosciences Custom PCR Arrays for B3GNT6
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GNT6 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B3GNT6 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GNT6 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GNT6 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6 |
Orthologs for B3GNT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for B3GNT6 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for B3GNT6 (if available) TreeFam Gene Tree for B3GNT6 (if available)  |
Paralogs for B3GNT6 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for B3GNT6 gene
- B3GNT32 B3GNT22 B3GNT52 B3GALT52 B3GALT12 B3GNT42 B3GALT42 B3GNT72
- B3GALT22 B3GNT82 B3GALNT12 B3GNT92
12 SIMAP similar genes for B3GNT6 using alignment to 4 protein entries: B3GN6_HUMAN (see all proteins):B3GNT3 B3GNT2 B3GNT4 B3GNT7 B3GALT1 B3GNT5 B3GALT5 B3GNT9 OK/KNS-cl.1 B3GALNT1 B3GALT2 B3GNT8
B3GNT6 for paralogs About GeneDecksing
|
Genomic Variants for B3GNT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GNT6 |
|
Disorders
/ Diseases for B3GNT6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
B3GNT6 for disorders About GeneDecksing
7 diseases for B3GNT6: About MalaCardskidney fibrosarcoma fibrosarcoma colon carcinoma prostate carcinoma adenoma carcinoma prostatitis Export disorders for B3GNT6 gene to outside databases
|
Publications for B3GNT6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for B3GNT6 gene integrated from 9 sources: (articles sorted by number of sources associating them with B3GNT6) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc- peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. (PubMed id 11821425)1, 2, 3 Iwai T.... Narimatsu H. (2002)
- Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. (PubMed id 15755813)1, 2 Iwai T.... Narimatsu H. (2005)
- Core3 O-glycan synthase suppresses tumor formation an d metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. (PubMed id 19395705)1 Lee S.H....Fukuda M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for B3GNT6 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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|
Genome Databases showing B3GNT6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing B3GNT6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GNT6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for B3GNT6 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT6 |
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About This Section
| Patent Information for B3GNT6 gene: Search GeneIP for patents involving B3GNT6
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for B3GNT6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6 |
|  |  |  | | | ThermoFisher Antibodies for B3GNT6 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT6 |
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