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Aliases for B3GNT6 Gene

Aliases for B3GNT6 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6 2 3
  • Core 3 Synthase 2 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase 6 3 4
  • Beta-1,3-Gn-T6 3 4
  • Beta3Gn-T6 3 4
  • BGnT-6 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase Protein 3
  • EC 2.4.1.- 4
  • B3Gn-T6 3

External Ids for B3GNT6 Gene

Summaries for B3GNT6 Gene

GeneCards Summary for B3GNT6 Gene

B3GNT6 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include galactosyltransferase activity and beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT6 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT6 Gene

Genomics for B3GNT6 Gene

Genomic Location for B3GNT6 Gene

Start:
77,034,341 bp from pter
End:
77,041,973 bp from pter
Size:
7,633 bases
Orientation:
Plus strand

Genomic View for B3GNT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT6 Gene

Regulatory Elements for B3GNT6 Gene

Proteins for B3GNT6 Gene

  • Protein details for B3GNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMB0-B3GN6_HUMAN
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
    Protein Accession:
    Q6ZMB0
    Secondary Accessions:
    • E9PKS1
    • Q6ZSC5
    • Q8TAZ4
    • Q8TDX1

    Protein attributes for B3GNT6 Gene

    Size:
    384 amino acids
    Molecular mass:
    42748 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Injection into nude mice significantly suppress lung metastasis, indicating that the core structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells

    Alternative splice isoforms for B3GNT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for B3GNT6 Gene

Proteomics data for B3GNT6 Gene at MOPED

Post-translational modifications for B3GNT6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn73, Asn77, and Asn196

Other Protein References for B3GNT6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT6 Gene

Domains for B3GNT6 Gene

Gene Families for B3GNT6 Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GNT6 Gene

UniProtKB/Swiss-Prot:

B3GN6_HUMAN
Family:
  • Belongs to the glycosyltransferase 31 family.:
    • Q6ZMB0
genes like me logo Genes that share domains with B3GNT6: view

Function for B3GNT6 Gene

Molecular function for B3GNT6 Gene

UniProtKB/Swiss-Prot Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs
UniProtKB/Swiss-Prot Induction: Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker for distinguishing between benign adenomas and premalignant lesions (at protein level)

Enzyme Numbers (IUBMB) for B3GNT6 Gene

Gene Ontology (GO) - Molecular Function for B3GNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IDA 11821425
GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity NAS 11821425
genes like me logo Genes that share ontologies with B3GNT6: view
genes like me logo Genes that share phenotypes with B3GNT6: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for B3GNT6 Gene

Localization for B3GNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GNT6 Gene COMPARTMENTS Subcellular localization image for B3GNT6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for B3GNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane NAS 11821425
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT6: view

Pathways for B3GNT6 Gene

genes like me logo Genes that share pathways with B3GNT6: view

Pathways by source for B3GNT6 Gene

UniProtKB/Swiss-Prot Q6ZMB0-B3GN6_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GNT6 Gene

Gene Ontology (GO) - Biological Process for B3GNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0009101 glycoprotein biosynthetic process NAS 11821425
GO:0016266 O-glycan processing TAS --
GO:0016269 O-glycan processing, core 3 NAS 11821425
genes like me logo Genes that share ontologies with B3GNT6: view

Transcripts for B3GNT6 Gene

mRNA/cDNA for B3GNT6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GNT6 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT6 Gene

No ASD Table

Relevant External Links for B3GNT6 Gene

GeneLoc Exon Structure for
B3GNT6
ECgene alternative splicing isoforms for
B3GNT6

Expression for B3GNT6 Gene

mRNA expression in normal human tissues for B3GNT6 Gene

mRNA differential expression in normal tissues according to GTEx for B3GNT6 Gene

This gene is overexpressed in Colon - Transverse (22.1), Stomach (11.4), Small Intestine - Terminal Ileum (7.0), and Esophagus - Mucosa (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for B3GNT6 Gene

SOURCE GeneReport for Unigene cluster for B3GNT6 Gene Hs.352622

mRNA Expression by UniProt/SwissProt for B3GNT6 Gene

Q6ZMB0-B3GN6_HUMAN
Tissue specificity: Present in stomach and colon (at protein level). Restricted in the stomach, colon and small intestine, where core 3 structure is present.
genes like me logo Genes that share expressions with B3GNT6: view

Orthologs for B3GNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for B3GNT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT6 36
  • 98.96 (n)
  • 98.7 (a)
B3GNT6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia B3GNT6 36
  • 85.22 (n)
  • 81.53 (a)
B3GNT6 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GNT6 36
  • 86.39 (n)
  • 82.47 (a)
B3GNT6 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3gnt6 36
  • 78.41 (n)
  • 71.51 (a)
B3gnt6 16
B3gnt6 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia B3gnt6 36
  • 78.8 (n)
  • 73.58 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 47 (a)
OneToMany
B3GNT6 36
  • 63.58 (n)
  • 55.59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt3 36
  • 51.42 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii b3gnt3 37
  • 39 (a)
ManyToMany
si:ch211-126g16.10 37
  • 38 (a)
ManyToMany
si:ch211-126g16.11 37
  • 38 (a)
ManyToMany
zgc:86586 37
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH04269 38
  • 31 (a)
Species with no ortholog for B3GNT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT6 Gene

ENSEMBL:
Gene Tree for B3GNT6 (if available)
TreeFam:
Gene Tree for B3GNT6 (if available)

Paralogs for B3GNT6 Gene

Selected SIMAP similar genes for B3GNT6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with B3GNT6: view

Variants for B3GNT6 Gene

Sequence variations from dbSNP and Humsavar for B3GNT6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1894008 -- 77,037,138(-) CCGCT(C/T)CTCAT intron-variant
rs2096737 -- 77,036,785(+) CCCAC(C/G)CTATG intron-variant
rs6592698 -- 77,037,223(+) GAGAC(A/G)CCAAG intron-variant
rs6592699 -- 77,037,292(+) GAATG(A/G)AAGCA intron-variant
rs6592700 -- 77,037,425(+) CAGCT(C/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B3GNT6 Gene

Variant ID Type Subtype PubMed ID
dgv1225n71 CNV Loss 21882294
nsv397 CNV Insertion 18451855

Relevant External Links for B3GNT6 Gene

HapMap Linkage Disequilibrium report
B3GNT6

Disorders for B3GNT6 Gene

No disorders were found for B3GNT6 Gene.

No data available for UniProtKB/Swiss-Prot for B3GNT6 Gene

Publications for B3GNT6 Gene

  1. Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc- peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. (PMID: 11821425) Iwai T. … Narimatsu H. (J. Biol. Chem. 2002) 2 3 4
  2. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. (PMID: 15755813) Iwai T. … Narimatsu H. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. (PMID: 19395705) Lee S.H. … Fukuda M. (J. Biol. Chem. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for B3GNT6 Gene

Sources for B3GNT6 Gene

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