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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B3GNT6 Gene

protein-coding   GIFtS: 47
GCID: GC11P076745

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase...

 Explore 7 diseases affiliated with
B3GNT6 via our new
 Human Malady Compendium 
Biological research products
for B3GNT6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6 (Core 3
Synthase)1 2
     Beta-1,3-N-Acetylglucosaminyltransferase Protein2
B3Gn-T61 2     Beta3Gn-T63
Beta-1,3-N-Acetylglucosaminyltransferase 62 3     UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 62
Core 3 Synthase2 3     Beta-1,3-Gn-T63
BGnT-62 3     Beta3Gn-T63
IMAGE:49070982     EC 2.4.1.-3
Beta-1,3-Gn-T63     

External Ids:    HGNC: 241411   Entrez Gene: 1921342   Ensembl: ENSG000001984887   UniProtKB: Q6ZMB03   

Export aliases for B3GNT6 gene to outside databases

Previous GC identifers: GC11M068646 GC11M067794 GC11M066362 GC11M065889 GC11M065890 GC11M065869 GC11P076425 GC11P073043


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important
precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type
O-glycans in digestive organs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B3GNT6 gene promoter:
         NF-1   NF-1/L   CUTL1   XBP-1   AP-4   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GNT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for B3GNT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GNT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.4

B3GNT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GNT6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P076745:  view genomic region     (about GC identifiers)

Start:
76,745,385 bp from pter      End:
76,753,096 bp from pter
Size:
7,712 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0 (See protein sequence)
Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6  
Size: 384 amino acids; 42748 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Miscellaneous: Injection into nude mice significantly suppress lung metastasis, indicating that the core structures of
O-glycans are profoundly involved in the metastatic capacity of cancer cells
Secondary accessions: Q6ZSC5 Q8TAZ4 Q8TDX1
Alternative splicing: 2 isoforms:  Q6ZMB0-1   Q6ZMB0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for B3GNT6: NX_Q6ZMB0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZMB0

  • B3GNT6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_619651.3  
    ENSEMBL proteins: 
     ENSP00000435352   ENSP00000435628   ENSP00000346256   ENSP00000403463  
    Reactome Protein details: Q6ZMB0
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016020membrane NAS11821425
    GO:0016021integral to membrane IEA--


    B3GNT6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    B3GNT6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002659 Glyco_trans_31

    Graphical View of Domain Structure for InterPro Entry Q6ZMB0

    ProtoNet protein and cluster: Q6ZMB0

    1 Blocks protein family: IPB002659 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Similarity: Belongs to the glycosyltransferase 31 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important
    precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type
    O-glycans in digestive organs
    Induction: Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker for
    distinguishing between benign adenomas and premalignant lesions (at protein level)

    Enzyme Number (IUBMB): EC 2.4.1.-1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity IDA11821425
    GO:0047223beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity NAS11821425


    B3GNT6 for ontologies           About GeneDecksing


    Animal Models:
         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for B3gnt6):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  tumorigenesis 

    B3GNT6 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    O-linked glycosylation of mucins0.28
    Mucin type O-Glycan biosynthesis0.00
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.15
    3Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for B3GNT6
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for B3GNT6):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Pathway: Protein modification; protein glycosylation


    B3GNT6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GNT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for B3GNT6 (ENSP000003462564) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT15ENSP000003442604STRING: ENSP00000344260
    GCNT1ENSP000003659204STRING: ENSP00000365920
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0009101glycoprotein biosynthetic process NAS11821425
    GO:0016266O-glycan processing TAS--
    GO:0016269O-glycan processing, core 3 NAS11821425
    GO:0043687post-translational protein modification TAS--


    B3GNT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for B3GNT6
    Search CenterWatch for drugs/clinical trials and news about B3GNT6 / B3GN6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for B3GNT6 gene: 
    NM_138706.3  

    Unigene Cluster for B3GNT6:

    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
    Hs.352622  [show with all ESTs]
    Unigene Representative Sequence: NM_138706
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533140(uc021qnp.1) ENST00000528622 ENST00000354301 ENST00000421061


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    Additional cDNA sequence: 

    AB073740.1 AK127544.1 AK172863.1 AK292773.1 AK313682.1 BC025357.1 BC103908.1 BC103909.2 
    BC103910.1 

    2 DOTS entries:

    DT.75195592  DT.101975582 

    19 AceView cDNA sequences:

    NM_138706 AW192172 BC025357 BX480039 AK172863 AB073740 CD636502 AK127544 
    CD636501 CD636508 CD636506 CD636507 BX477104 CD636505 CD636503 AW182889 
    BP383116 CD636499 CD636500 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    B3GNT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See B3GNT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for B3GNT6

    SOURCE GeneReport for Unigene cluster: Hs.352622

    UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Tissue specificity: Present in stomach and colon (at protein level). Restricted in the stomach, colon and small
    intestine, where core 3 structure is present

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for B3GNT6 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008591031 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6-like less 63.58(n)
    55.59(a)
      100859103  XM_003643418.1  XP_003643466.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    30(a)
    29(a)
    possible ortholog
    possible ortholog
    GL343939.1(35045-36472)
    GL343939.1(65643-68570)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1715386
    si:ch211-126g16.106
    (see all 4)
    si:ch211-126g16.10
    (see all 4)
    40(a)
    40(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    8(14147443-14157973)
    8(14089482-14091715)
    fruit fly
    (Drosophila melanogaster)
    Insecta BEST:GH042693 N-acetyllactosaminide
    beta-1,3-N-acetylglucosaminyltransferase less
    31(a)   60B11   --


    ENSEMBL Gene Tree for B3GNT6 (if available)
    TreeFam Gene Tree for B3GNT6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for B3GNT6 gene
    B3GNT32  B3GNT22  B3GNT52  B3GALT52  B3GALT12  B3GNT42  B3GALT42  B3GNT72  
    B3GALT22  B3GNT82  B3GALNT12  B3GNT92  
    12 SIMAP similar genes for B3GNT6 using alignment to 4 protein entries:     B3GN6_HUMAN (see all proteins):
    B3GNT3    B3GNT2    B3GNT4    B3GNT7    B3GALT1    B3GNT5
    B3GALT5    B3GNT9    OK/KNS-cl.1    B3GALNT1    B3GALT2    B3GNT8

    B3GNT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GNT6
    DNA2.0 Custom Variant and Variant Library Synthesis for B3GNT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    B3GNT6 for disorders           About GeneDecksing

    7 diseases for B3GNT6:    About MalaCards
    kidney fibrosarcoma    fibrosarcoma    colon carcinoma    prostate carcinoma
    adenoma    carcinoma    prostatitis


    Export disorders for B3GNT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for B3GNT6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with B3GNT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc- peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. (PubMed id 11821425)1, 2, 3 Iwai T.... Narimatsu H. (2002)
    2. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. (PubMed id 15755813)1, 2 Iwai T.... Narimatsu H. (2005)
    3. Core3 O-glycan synthase suppresses tumor formation an d metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. (PubMed id 19395705)1 Lee S.H....Fukuda M. (2009)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 192134 HGNC: 24141 AceView: Galactosyl_T.2 Ensembl:ENSG00000198488 euGenes: HUgn192134
    ECgene: B3GNT6 Kegg: 192134 H-InvDB: B3GNT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for B3GNT6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for B3GNT6 gene:
    Search GeneIP for patents involving B3GNT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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