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Aliases for B3GNT6 Gene

Aliases for B3GNT6 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6 2 3 4 5
  • Core 3 Synthase 2 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase 6 3 4
  • Beta-1,3-Gn-T6 3 4
  • Beta3Gn-T6 3 4
  • BGnT-6 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase Protein 3
  • EC 4
  • B3Gn-T6 3

External Ids for B3GNT6 Gene

Previous GeneCards Identifiers for B3GNT6 Gene

  • GC11M068646
  • GC11M067794
  • GC11M066362
  • GC11M065889
  • GC11M065890
  • GC11M065869
  • GC11P076425
  • GC11P076745
  • GC11P073043

Summaries for B3GNT6 Gene

GeneCards Summary for B3GNT6 Gene

B3GNT6 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include galactosyltransferase activity and beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT6 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT6 Gene

Genomics for B3GNT6 Gene

Regulatory Elements for B3GNT6 Gene

Enhancers for B3GNT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B3GNT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GNT6 Gene

77,034,341 bp from pter
77,041,973 bp from pter
7,633 bases
Plus strand

Genomic View for B3GNT6 Gene

Genes around B3GNT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT6 Gene

Proteins for B3GNT6 Gene

  • Protein details for B3GNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
    Protein Accession:
    Secondary Accessions:
    • E9PKS1
    • Q6ZSC5
    • Q8TAZ4
    • Q8TDX1

    Protein attributes for B3GNT6 Gene

    384 amino acids
    Molecular mass:
    42748 Da
    Quaternary structure:
    No Data Available
    • Injection into nude mice significantly suppress lung metastasis, indicating that the core structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells.

    Alternative splice isoforms for B3GNT6 Gene


neXtProt entry for B3GNT6 Gene

Proteomics data for B3GNT6 Gene at MOPED

Post-translational modifications for B3GNT6 Gene

  • Glycosylation at Asn 73, Asn 77, and Asn 196
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for B3GNT6 Gene

Domains & Families for B3GNT6 Gene

Gene Families for B3GNT6 Gene

Protein Domains for B3GNT6 Gene

Suggested Antigen Peptide Sequences for B3GNT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 31 family.
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT6: view

Function for B3GNT6 Gene

Molecular function for B3GNT6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.3 mM for GalNAc-alpha-Bn {ECO:0000269 PubMed:7655172}; Vmax=4.5 nmol/h/mg enzyme with GalNAc-alpha-Bn as substrate {ECO:0000269 PubMed:7655172};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-glucosamine + O(3)-(N-acetyl-alpha-D-galactosaminyl)-L-threonyl/L-seryl-[protein] = UDP + O(3)-(N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl)-L-threonyl/L-seryl-[protein].
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.
UniProtKB/Swiss-Prot Induction:
Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker for distinguishing between benign adenomas and premalignant lesions (at protein level).

Enzyme Numbers (IUBMB) for B3GNT6 Gene

genes like me logo Genes that share phenotypes with B3GNT6: view

Animal Models for B3GNT6 Gene

MGI Knock Outs for B3GNT6:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GNT6 Gene

Localization for B3GNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for B3GNT6 Gene COMPARTMENTS Subcellular localization image for B3GNT6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for B3GNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT6: view

Pathways & Interactions for B3GNT6 Gene

genes like me logo Genes that share pathways with B3GNT6: view

Pathways by source for B3GNT6 Gene

UniProtKB/Swiss-Prot Q6ZMB0-B3GN6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT6 Gene

Gene Ontology (GO) - Biological Process for B3GNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0009101 glycoprotein biosynthetic process NAS 11821425
GO:0016269 O-glycan processing, core 3 NAS 11821425
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with B3GNT6: view

No data available for SIGNOR curated interactions for B3GNT6 Gene

Drugs & Compounds for B3GNT6 Gene

No Compound Related Data Available

Transcripts for B3GNT6 Gene

mRNA/cDNA for B3GNT6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GNT6 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT6 Gene

No ASD Table

Relevant External Links for B3GNT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B3GNT6 Gene

mRNA expression in normal human tissues for B3GNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT6 Gene

This gene is overexpressed in Colon - Transverse (x22.1), Stomach (x11.4), Small Intestine - Terminal Ileum (x7.0), and Esophagus - Mucosa (x6.8).

Protein differential expression in normal tissues from HIPED for B3GNT6 Gene

This gene is overexpressed in Colon (50.4) and Testis (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GNT6 Gene

SOURCE GeneReport for Unigene cluster for B3GNT6 Gene Hs.352622

mRNA Expression by UniProt/SwissProt for B3GNT6 Gene

Tissue specificity: Present in stomach and colon (at protein level). Restricted in the stomach, colon and small intestine, where core 3 structure is present.
genes like me logo Genes that share expression patterns with B3GNT6: view

Protein tissue co-expression partners for B3GNT6 Gene

Primer Products

Orthologs for B3GNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for B3GNT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia B3GNT6 35
  • 85.22 (n)
  • 81.53 (a)
B3GNT6 36
  • 79 (a)
(Canis familiaris)
Mammalia B3GNT6 35
  • 86.39 (n)
  • 82.47 (a)
B3GNT6 36
  • 77 (a)
(Mus musculus)
Mammalia B3gnt6 35
  • 78.41 (n)
  • 71.51 (a)
B3gnt6 16
B3gnt6 36
  • 65 (a)
(Pan troglodytes)
Mammalia B3GNT6 35
  • 98.96 (n)
  • 98.7 (a)
B3GNT6 36
  • 98 (a)
(Rattus norvegicus)
Mammalia B3gnt6 35
  • 78.8 (n)
  • 73.58 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Gallus gallus)
Aves B3GNT6 35
  • 63.58 (n)
  • 55.59 (a)
-- 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt3 35
  • 51.42 (n)
  • 50 (a)
(Danio rerio)
Actinopterygii b3gnt3 36
  • 39 (a)
si:ch211-126g16.10 36
  • 38 (a)
si:ch211-126g16.11 36
  • 38 (a)
zgc:86586 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH04269 37
  • 31 (a)
Species with no ortholog for B3GNT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT6 Gene

Gene Tree for B3GNT6 (if available)
Gene Tree for B3GNT6 (if available)

Paralogs for B3GNT6 Gene

(9) SIMAP similar genes for B3GNT6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with B3GNT6: view

Variants for B3GNT6 Gene

Sequence variations from dbSNP and Humsavar for B3GNT6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1894008 -- 77,037,138(-) CCGCT(C/T)CTCAT intron-variant
rs2096737 -- 77,036,785(+) CCCAC(C/G)CTATG intron-variant
rs7115080 -- 77,036,214(+) GTAGA(C/G)AGTTG intron-variant
rs11604379 -- 77,032,678(+) atata(C/T)acaca upstream-variant-2KB
rs61089763 -- 77,032,732(+) ATATA(C/T)ACATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for B3GNT6 Gene

Variant ID Type Subtype PubMed ID
dgv1225n71 CNV Loss 21882294
nsv397 CNV Insertion 18451855

Variation tolerance for B3GNT6 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.05; 92.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for B3GNT6 Gene

Disorders for B3GNT6 Gene

Relevant External Links for B3GNT6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for B3GNT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT6 Gene

Publications for B3GNT6 Gene

  1. Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc- peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. (PMID: 11821425) Iwai T. … Narimatsu H. (J. Biol. Chem. 2002) 2 3 4 67
  2. Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. (PMID: 19395705) Lee S.H. … Fukuda M. (J. Biol. Chem. 2009) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. (PMID: 15755813) Iwai T. … Narimatsu H. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3
  5. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3

Products for B3GNT6 Gene

Sources for B3GNT6 Gene