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Aliases & Descriptions for B3GNT6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B3Gn-T6 1, 2 | | BGnT-6 3 | | Beta-1,3-N-acetylglucosaminyltransferase-6 3 | | Beta3Gn-T6 3 | | EC 2.4.1.- 3 | | IMAGE:4907098 2 | | MGC119334 2 | | MGC119336 2 | | MGC119337 2 |
| | | Descriptions |
|---|
| Core 3 synthase 3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase) 2 | | beta-1,3-N-acetylglucosaminyltransferase protein 2 |
|
| | Search outside databases for aliases for B3GNT6 genePrevious GC identifers: GC11M068646 GC11M067794 GC11M066362 GC11M065889 GC11M065890 GC11M065869 |
Summaries for B3GNT6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs |
Genomic Location for B3GNT6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B3GNT6 gene 
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.4B3GNT6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P076425:
(about GC identifiers)
Start:
|
76,423,083 bp from pter |
End:
|
76,430,668 bp from pter |
Size:
|
7,586 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033927.7
| Proteins for B3GNT6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0 (See
protein sequence)Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 Size: 384 amino acids; 42748 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Miscellaneous: Injection into nude mice significantly suppress lung metastasis, indicating that the core structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells
Secondary accessions: Q6ZSC5 Q8TAZ4 Q8TDX1Alternative splicing: 2 isoforms: Q6ZMB0-1 Q6ZMB0-2 REFSEQ proteins: NP_619651.3
ENSEMBL proteins: ENSP00000346256
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B3GNT6: Assays for B3GNT6: | Protein
Domains/ Families for B3GNT6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6ZMB0
ProtoNet protein and cluster: Q6ZMB0 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Similarity: Belongs to the glycosyltransferase 31 family | Gene Function for B3GNT6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138706
Applied Biosystems Silencer® siRNAs for B3GNT6
Sigma-Aldrich siRNA for B3GNT6  Sigma-Aldrich shRNA for B3GNT6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138706                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138706                                  untagged cDNA clone in CMV expression vector: NM_138706 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_138706
UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organsInduction: Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker for distinguishing between benign adenomas and premalignant lesions (at protein level)Enzyme Number (IUBMB): EC 2.4.1.- 3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008378 | galactosyltransferase activity |
IDA | 11821425 | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity |
NAS | 11821425 | About this table | Pathways & Interactions for B3GNT6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for B3GNT6 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Pathway: Protein modification; protein glycosylation 5/23 Interacting proteins for B3GNT6 (ENSP000003462563) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for B3GNT6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B3GNT6
|
Transcripts for B3GNT6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138706
Sigma-Aldrich siRNA for B3GNT6  Sigma-Aldrich shRNA for B3GNT6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_138706 REFSEQ mRNAs for B3GNT6 gene: NM_138706.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138706               OriGene GFP tagged cDNA clone in CMV expression vector: NM_138706                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138706                                  untagged cDNA clone in CMV expression vector: NM_138706  Additional cDNA sequence: AB073740.1 AK127544.1 AK172863.1 AK292773.1 AK313682.1 BC025357.1 BC103908.1 BC103909.2 BC103910.1 2 DOTS entries: DT.75195592 DT.101975582 19 AceView cDNA sequences:BC025357 BX480039 AK172863 AB073740 AW192172 NM_138706 AK127544 CD636501 CD636502 CD636507 CD636508 CD636506 CD636505 BX477104 CD636503 BP383116 AW182889 CD636500 CD636499
highest scoring ESTs for B3GNT6:AB073740 AK172863 AW192172 BC025357 BX477104 CD636501 CD636502 CD636503 CD636505 CD636506 Unigene Cluster for B3GNT6: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase) Hs.352622 [show with all ESTs]Unigene Representative Sequence: NM_138706
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000354301
|
Expression for B3GNT6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B3GNT6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B3GNT6
1 / 2 2 probe-sets matching B3GNT6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.352622
Expression variation in blood from EXPOLDB for B3GNT6 UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0Tissue specificity: Present in stomach and colon (at protein level). Restricted in the stomach, colon and small intestine, where core 3 structure is present |
Orthologs for B3GNT6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B3GNT6 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
B3GNT11 |
-- |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more |
86.63(n) 82.63(a) |
485176 XM_542294.2 XP_542294.2 |
chimpanzee (Pan troglodytes) |
B3GNT11 |
-- |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more |
99.05(n) 98.7(a) |
451437 XM_001175035.1 XP_001175035.1 |
rat (Rattus norvegicus) |
B3gnt61 |
-- |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more |
78.89(n) 73.58(a) |
292325 XM_217903.4 XP_217903.3 |
mouse (Mus musculus) |
B3gnt61, 5 |
75
|
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more1, 5 |
78.62(n)1 71.7(a)1 |
2724111 NM_001081167.11 NP_001074636.11 AK1404295 BC0397895 (see all 6) |
fruit fly (Drosophila melanogaster) |
BEST:GH042693 |
60B11 |
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase |
31(a) |
-- |
About this table Species with no ortholog for B3GNT6
ENSEMBL Gene Tree for B3GNT6 | Paralogs for B3GNT6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for B3GNT6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B3GNT6 (up to first 250kb)
|
Disorders & Mutations for B3GNT6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for B3GNT6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B3GNT6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for B3GNT6 gene: |
Search for B3GNT6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B3GNT6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B3GNT6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GNT6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT6 |
|
| | | About This Section
| --
| Services for B3GNT6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for B3GNT6:

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Incremental update: 13 Oct 2009
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