Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



B3GNT6 Gene

protein-coding   GIFtS: 51
GCID: GC11P076745

UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 6 (Core 3
Synthase)1 2
     Beta-1,3-N-Acetylglucosaminyltransferase Protein2
Beta-1,3-N-Acetylglucosaminyltransferase 62 3     beta3Gn-T62
Core 3 Synthase2 3     UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 62
BGnT-62 3     Beta-1,3-Gn-T63
B3Gn-T62     Beta3Gn-T63
beta-1,3-Gn-T62     EC 2.4.1.-3

External Ids:    HGNC: 241411   Entrez Gene: 1921342   Ensembl: ENSG000001984887   OMIM: 6153155   UniProtKB: Q6ZMB03   

Export aliases for B3GNT6 gene to outside databases

Previous GC identifers: GC11M068646 GC11M067794 GC11M066362 GC11M065889 GC11M065890 GC11M065869 GC11P076425 GC11P073043


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for B3GNT6 Gene:
B3GNT6 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)) is a protein-coding gene. Diseases associated with B3GNT6 include kidney fibrosarcoma, and fibrosarcoma. GO annotations related to this gene include galactosyltransferase activity and beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT3.

UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an
important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of
mucin-type O-glycans in digestive organs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the B3GNT6 gene promoter:
         NF-1   NF-1/L   CUTL1   XBP-1   AP-4   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GNT6 promoter sequence
   Search Chromatin IP Primers for B3GNT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B3GNT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.4

B3GNT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GNT6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P076745:  view genomic region     (about GC identifiers)

Start:
76,745,385 bp from pter      End:
76,753,096 bp from pter
Size:
7,712 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0 (See protein sequence)
Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6  
Size: 384 amino acids; 42748 Da
Miscellaneous: Injection into nude mice significantly suppress lung metastasis, indicating that the core
structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells
Secondary accessions: E9PKS1 Q6ZSC5 Q8TAZ4 Q8TDX1
Alternative splicing: 3 isoforms:  Q6ZMB0-1   Q6ZMB0-2   Q6ZMB0-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for B3GNT6: NX_Q6ZMB0

Explore proteomics data for B3GNT6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn73, Asn77, Asn196
  • Modification sites at PhosphoSitePlus

  • See B3GNT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_619651.3  
    ENSEMBL proteins: 
     ENSP00000435352   ENSP00000435628   ENSP00000346256   ENSP00000403463  
    Reactome Protein details: Q6ZMB0

    B3GNT6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for B3GNT6 (Beta-1,3-N-Acetylglucosaminyltransferase 6/B3GNT6)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for B3GNT6
    OriGene Protein Over-expression Lysate for B3GNT6
    OriGene MassSpec for B3GNT6
    OriGene Custom Protein Services for B3GNT6
    GenScript Custom Purified and Recombinant Proteins Services for B3GNT6
    Novus Biologicals B3GNT6 Lysates
    Sino Biological Recombinant Protein for B3GNT6
    Sino Biological Cell Lysate for B3GNT6
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    B3GNT6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for B3GNT6
    Novus Biologicals B3GNT6 Antibodies
    Abcam antibodies for B3GNT6
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for B3GNT6
    LSBio Antibodies in human, mouse, rat for B3GNT6

    B3GNT6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for B3GNT6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for B3GNT6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases

    1 InterPro protein domain:
     IPR002659 Glyco_trans_31

    Graphical View of Domain Structure for InterPro Entry Q6ZMB0

    ProtoNet protein and cluster: Q6ZMB0

    1 Blocks protein domain: IPB002659 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Similarity: Belongs to the glycosyltransferase 31 family


    B3GNT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3GN6_HUMAN, Q6ZMB0
    Function: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an
    important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of
    mucin-type O-glycans in digestive organs
    Induction: Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker for
    distinguishing between benign adenomas and premalignant lesions (at protein level)

         Enzyme Number (IUBMB): EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity IDA11821425
    GO:0047223beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity NAS11821425
         
    B3GNT6 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for B3gnt6):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  tumorigenesis 

    B3GNT6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B3GNT6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for B3GNT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for B3GNT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for B3GNT6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat B3GNT6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate B3GNT6:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidB3GNT6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for B3GNT6
    Predesigned siRNA for gene silencing in human, mouse, rat B3GNT6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for B3GNT6

    Clone
    Products:
         
    OriGene clones in human, mouse for B3GNT6 (see all 5)
    OriGene ORF clones in mouse, rat for B3GNT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: B3GNT6 (NM_138706)
    Sino Biological Human cDNA Clone for B3GNT6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GNT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for B3GNT6
    Browse ESI BIO Cell Lines and PureStem Progenitors for B3GNT6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    B3GN6_HUMAN, Q6ZMB0: Golgi apparatus membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016020membrane NAS11821425
    GO:0016021integral component of membrane IEA--

    B3GNT6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for B3GNT6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Mucin type O-Glycan biosynthesis0.47
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for B3GNT6
        O-linked glycosylation of mucins


    2 Kegg Pathways  (Kegg details for B3GNT6):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Pathway: Protein modification; protein glycosylation


    B3GNT6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for B3GNT6
    Interactions:

        Search GeneGlobe Interaction Network for B3GNT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for B3GNT6 (ENSP000003462564) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT15ENSP000003442604STRING: ENSP00000344260
    GCNT1ENSP000003659204STRING: ENSP00000365920
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0009101glycoprotein biosynthetic process NAS11821425
    GO:0016266O-glycan processing TAS--
    GO:0016269O-glycan processing, core 3 NAS11821425
    GO:0043687post-translational protein modification TAS--

    B3GNT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for B3GNT6 (B3GN6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for B3GNT6 gene: 
    NM_138706.4  

    Unigene Cluster for B3GNT6:

    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
    Hs.352622  [show with all ESTs]
    Unigene Representative Sequence: NM_138706
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533140(uc021qnp.1) ENST00000528622 ENST00000354301 ENST00000421061

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat B3GNT6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate B3GNT6:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidB3GNT6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for B3GNT6
    Predesigned siRNA for gene silencing in human, mouse, rat B3GNT6
    Clone
    Products:
         
    OriGene clones in human, mouse for B3GNT6 (see all 5)
    OriGene ORF clones in mouse, rat for B3GNT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: B3GNT6 (NM_138706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GNT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for B3GNT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat B3GNT6
      QuantiTect SYBR Green Assays in human, mouse, rat B3GNT6
      QuantiFast Probe-based Assays in human, mouse, rat B3GNT6

    Additional mRNA sequence: 

    AB073740.1 AK127544.1 AK172863.1 AK292773.1 AK313682.1 BC025357.1 BC103908.1 BC103909.2 
    BC103910.1 

    2 DOTS entries:

    DT.75195592  DT.101975582 

    19 AceView cDNA sequences:

    AK172863 AB073740 AW192172 BX480039 BC025357 NM_138706 CD636502 AK127544 
    CD636501 CD636507 CD636506 CD636505 BX477104 CD636508 BP383116 AW182889 
    CD636503 CD636500 CD636499 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    B3GNT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    B3GNT6 Expression
    About this image

    B3GNT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    B3GNT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352622

    UniProtKB/Swiss-Prot: B3GN6_HUMAN, Q6ZMB0
    Tissue specificity: Present in stomach and colon (at protein level). Restricted in the stomach, colon and small
    intestine, where core 3 structure is present

        Custom PCR Arrays for B3GNT6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for B3GNT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat B3GNT6
    QuantiTect SYBR Green Assays in human, mouse, rat B3GNT6
    QuantiFast Probe-based Assays in human, mouse, rat B3GNT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for B3GNT6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B3gnt61 , 5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more1, 5 78.41(n)1
    71.51(a)1
      7 (53.63 cM)5
    2724111  NM_001081167.11  NP_001074636.11 
     981924155 
    chicken
    (Gallus gallus)
    Aves B3GNT61 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 63.58(n)
    55.59(a)
      100859103  XM_003643418.2  XP_003643466.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia b3gnt31 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 51.42(n)
    50(a)
      100380117  XM_002935868.1  XP_002935914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii b3gnt36
    zgc:865866
    (see all 4)
    zgc:86586
    (see all 4)
    39(a)
    38(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    8(14147443-14157973) ENSDARG00000058100
    8(14051336-14058465) ENSDARG00000043482


    ENSEMBL Gene Tree for B3GNT6 (if available)
    TreeFam Gene Tree for B3GNT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for B3GNT6 gene
    B3GNT32  B3GNT22  B3GNT52  B3GALT52  B3GALT12  B3GNT42  B3GALT42  B3GALT22  
    B3GNT72  B3GNT82  B3GALNT12  B3GNT92  
    9 SIMAP similar genes for B3GNT6 using alignment to 3 protein entries:     B3GN6_HUMAN (see all proteins):
    B3GNT3    B3GNT2    B3GNT7    B3GNT4    B3GALT1    B3GNT5
    B3GALT5    B3GNT9    B3GALT2

    B3GNT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for B3GNT6 (see all 239)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019256861,2
    --76609010(+) TAAAT-/AAATA 
            
    AATAA
    1 -- us2k10--------
    rs3696542401,2
    --76609035(+) TACAT-/ACATATA 1 -- us2k10--------
    rs116043791,2
    C,H--76609071(+) atataT/Cacaca 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs2009416541,2
    --76609086(+) TACAT-/ACATATA 1 -- us2k10--------
    rs1908045421,2
    --76609087(+) ACATAC/TATATA 1 -- us2k10--------
    rs1830378791,2
    --76609097(+) ATATAC/TATACA 1 -- us2k10--------
    rs2019974321,2
    C--76609098(+) ATATA-/ATAC  
            
    TACAT
    1 -- us2k10--------
    rs561277691,2
    --76609113(+) ACATAC/TATATA 1 -- us2k10--------
    rs2009528361,2
    --76609114(+) CATAC-/ATATATA 1 -- us2k10--------
    rs1399672591,2
    --76609123(+) ATATAC/TATACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for B3GNT6 (76745385 - 76753096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for B3GNT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv397CNV Insertion18451855
    dgv1225n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing B3GNT6
    DNA2.0 Custom Variant and Variant Library Synthesis for B3GNT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615315    OMIM disorders: --

    4 diseases for B3GNT6:    About MalaCards
    kidney fibrosarcoma    fibrosarcoma    adenoma    prostatitis


    B3GNT6 for disorders           About GeneDecksing


    Export disorders for B3GNT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for B3GNT6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with B3GNT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc- peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. (PubMed id 11821425)1, 2, 3 Iwai T.... Narimatsu H. (J. Biol. Chem. 2002)
    2. Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells. (PubMed id 15755813)1, 2 Iwai T.... Narimatsu H. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    3. Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. (PubMed id 19395705)1 Lee S.H....Fukuda M. (J. Biol. Chem. 2009)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (Genomics 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 192134 HGNC: 24141 AceView: Galactosyl_T.2 Ensembl:ENSG00000198488 euGenes: HUgn192134
    ECgene: B3GNT6 Kegg: 192134 H-InvDB: B3GNT6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for B3GNT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for B3GNT6 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for B3GNT6 gene:
    Search GeneIP for patents involving B3GNT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for B3GNT6 (Beta-1,3-N-Acetylglucosaminyltransferase 6/B3GNT6)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for B3GNT6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for B3GNT6  
     OriGene MassSpec something-or-other for B3GNT6   OriGene clones in human, mouse for B3GNT6  
     OriGene qSTAR qPCR primer pairs in human, mouse for B3GNT6   OriGene Purified Protein for B3GNT6  
     OriGene ORF clones in mouse, rat for B3GNT6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for B3GNT6   OriGene Custom Protein Services for B3GNT6  

     
     
     Block miRNA regulation of human, mouse, rat B3GNT6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing B3GNT6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B3GNT6 Predesigned siRNA for gene silencing in human, mouse, rat B3GNT6
     QuantiFast Probe-based Assays in human, mouse, rat B3GNT6 QuantiTect SYBR Green Assays in human, mouse, rat B3GNT6
     Custom PCR Arrays for B3GNT6 Search Chromatin IP Primers for B3GNT6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat B3GNT6  Search GeneGlobe Interaction Network for B3GNT6
     Regulatory tfbs in B3GNT6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for B3GNT6 GenScript cDNA clones with any tag delivered in your preferred vector for B3GNT6
     GenScript Custom Assay Services for B3GNT6 GenScript Custom overexpressing Cell Line Services for B3GNT6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for B3GNT6 (B3GN6)
     Proteins for B3GNT6
     Cell Lysates for B3GNT6
     cDNA Clones for B3GNT6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     B3GNT6 antibodies
     B3GNT6 lysates
     Antibodies for B3GNT6
     See all of Abcam's Antibodies, Kits and Proteins for B3GNT6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for B3GNT6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT6
     SwitchGear 3'UTR luciferase reporter plasmids for B3GNT6
     SwitchGear Promoter luciferase reporter plasmids for B3GNT6
     ThermoFisher Antibodies for B3GNT6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GNT6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B3GNT6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for B3GNT6
     LSBio Antibodies in human, mouse, rat for B3GNT6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      B3GNT6 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4