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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B3GNT5 Gene

protein-coding   GIFtS: 48
GCID: GC03P182971

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase...
  Search for B3GNT5
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Aliases
for B3GNT5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 51 2     Beta 1,3 N-Acetyglucosaminyltransferase Lc3 Synthase2
B3GN-T51 2     Beta-1,3-Gn-T53
Beta3Gn-T53     Beta-1,3-N-Acetylglucosaminyltransferase BGnT-52
Beta-1,3-N-Acetylglucosaminyltransferase 52 3     Lactosylceramide 1,3-N-Acetyl-Beta-D-Glucosaminyltransferase2
Lactotriaosylceramide Synthase2 3     Beta-1,3-Gn-T53
Lc(3)Cer Synthase2 3     Beta3Gn-T53
Lc3 Synthase2 3     EC 2.4.1.2063
BGnT-52 3     EC 2.4.18
UDP-GlcNAc:Beta-Gal Beta-1,3-N-Acetylglucosaminyltransferase 52 3     

External Ids:    HGNC: 156841   Entrez Gene: 840022   Ensembl: ENSG000001765977   UniProtKB: Q9BYG03   

Export aliases for B3GNT5 gene to outside databases

Previous GC identifers: GC03P179760 GC03P183826 GC03P184373 GC03P184291 GC03P184453 GC03P180376


Summaries
for B3GNT5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for B3GNT5:
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane
protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely
candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on
glycolipids. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series
carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate
structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer;
paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively.
Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development




Genomic Views
for B3GNT5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B3GNT5 gene promoter:
         Pbx1a   AML1a   Lmo2   RelA   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   RORalpha1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: B3GNT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for B3GNT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GNT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q28

B3GNT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GNT5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P182971:  view genomic region     (about GC identifiers)

Start:
 182,971,032 bp from pter      End:
 183,016,292 bp from pter
Size:
 45,261 bases      Orientation:
 plus strand

Proteins
for B3GNT5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0 (See protein sequence)
Recommended Name: Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase  
Size: 378 amino acids; 44053 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Sequence caution: Sequence=BAD92754.1; Type=Frameshift; Positions=347;
Secondary accessions: D3DNS5 Q59FE3 Q7L9Z5 Q8WWP9

Explore the universe of human proteins at neXtProt for B3GNT5: NX_Q9BYG0

4/7 DME Specific Peptides for B3GNT5 (Q9BYG0) (see all 7)
 MMTSHGH  PYHPCIY  YIDDVFMG  KSYSYRYL 

B3GNT5 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_114436.1  
ENSEMBL proteins: 
 ENSP00000316173   ENSP00000418785   ENSP00000420778   ENSP00000418477   ENSP00000417868  
 ENSP00000417301  
Reactome Protein details: Q9BYG0
Human Recombinant Protein Products: 
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Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane TAS--
GO:0005622intracellular IDA11384981
GO:0016020membrane ----
GO:0016021integral to membrane IEA--


B3GNT5 for ontologies           About GeneDecksing



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ThermoFisher Antibodies for B3GNT5

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Protein Domains /
Families
for B3GNT5 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
B3GNT5 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002659 Glyco_trans_31

Graphical View of Domain Structure for InterPro Entry Q9BYG0

ProtoNet protein and cluster: Q9BYG0

1 Blocks protein family: IPB002659 Glycosyl transferase

UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
Similarity: Belongs to the glycosyltransferase 31 family


Function
for B3GNT5 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series
carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate
structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer;
paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively.
Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development
Catalytic activity: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP +
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Induction: Up-regulated by stimulation with retinoic acid and down-regulated with 12-O-tetradecanoylphorbol-13-acetate
(TPA)

Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.2061

miRNA
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8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate B3GNT5 (see all 32):
hsa-miR-30c hsa-miR-3607-3p hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-944 hsa-miR-30d hsa-miR-1297
SwitchGear 3'UTR luciferase reporter plasmid: B3GNT5 3' UTR sequence
Inhib. RNA
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OriGene siRNA: B3GNT5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GNT5

Gene Editing
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Clone
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Cell Line
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In Situ Assay
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008378galactosyltransferase activity IEA--
GO:0008457beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity IDA11384981
GO:0008917lipopolysaccharide N-acetylglucosaminyltransferase activity IEA--
GO:0047256lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity IEA--


B3GNT5 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-outs for B3GNT5: B3gnt5tm1.1Cfg B3gnt5tm1Nari B3gnt5tm1Then B3gnt5tm2.1Big B3gnt5tm1Big
     6 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for B3gnt5):
 growth/size  hematopoietic system  immune system  mortality/aging  no phenotypic analysis 
 reproductive system 

B3GNT5 for phenotypes           About GeneDecksing


Pathways & Interactions
for B3GNT5 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Asparagine N-linked glycosylation
Post-translational protein modification0.44
Metabolism of proteins0.15
2Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - lacto and neolacto series1.00
3Metabolism
Metabolic pathways0.38
4Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
O-linked glycosylation of mucins0.28

Pathway sources
See GeneCards unified pathways
Show all pathways


3        Reactome Pathways for B3GNT5
    O-linked glycosylation of mucins
Metabolism of proteins
Post-translational protein modification


2         Kegg Pathways  (Kegg details for B3GNT5):
    Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways

UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
Pathway: Protein modification; protein glycosylation


B3GNT5 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GNT5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for B3GNT5 (ENSP000003161734) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

InteractantInteraction Details
GeneCardExternal ID(s)
B3GALT2ENSP000003564044STRING: ENSP00000356404
B3GALT1ENSP000003037404STRING: ENSP00000303740
B3GALT5ENSP000003433184STRING: ENSP00000343318
B4GALT1ENSP000003690554STRING: ENSP00000369055
B4GALT2ENSP000003492934STRING: ENSP00000349293
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006486protein glycosylation TAS11384981
GO:0007417central nervous system development IDA11384981
GO:0009247glycolipid biosynthetic process TAS11384981
GO:0016266O-glycan processing TAS--
GO:0043687post-translational protein modification TAS--


B3GNT5 for ontologies           About GeneDecksing



Drugs & Compounds
for B3GNT5 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for B3GNT5

10/521 HMDB Compounds for B3GNT5 (see all 521)    About this table
CompoundSynonyms CAS #PubMed Ids
3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
Search CenterWatch for drugs/clinical trials and news about B3GNT5 / B3GN5 

Transcripts
for B3GNT5 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for B3GNT5 gene: 
NM_032047.4  

Unigene Cluster for B3GNT5:

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Hs.718506  [show with all ESTs]
Unigene Representative Sequence: NM_032047
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000326505(uc003flk.3 uc003fll.3 uc003flm.3) ENST00000493370
ENST00000480551 ENST00000464191 ENST00000460419 ENST00000464923 ENST00000496270
ENST00000465010 ENST00000488301 ENST00000477699 ENST00000481531 ENST00000462559(uc003fln.1)


miRNA
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hsa-miR-30c hsa-miR-3607-3p hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-944 hsa-miR-30d hsa-miR-1297
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Inhib. RNA
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Clone
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Additional cDNA sequence: 

AB045278.1 AB209517.1 AF368169.1 AJ304505.1 AK074235.1 AK074424.1 AK091474.1 

9 DOTS entries:

DT.91907482  DT.311018  DT.100785405  DT.100785406  DT.120868479  DT.120868381  DT.120868418  DT.40111816 
DT.95162132 

24/123 AceView cDNA sequences (see all 123):

BF223815 BU684277 AX747008 AW452443 AW662544 AK074424 BF940440 NM_032047 
AK126337 BX499010 AW516070 AK074235 AK091474 BC028058 N57022 AW026723 
AW150816 AI825936 AI467964 BM142526 CD678910 CD678911 AB045278 BG236076 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT5    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d
SP1:                                                                  
SP2:                                -                                 
SP3:                          -     -                                 
SP4:        -     -     -     -     -     -                           
SP5:              -     -     -     -     -                           


ECgene alternative splicing isoforms for B3GNT5

Expression
for B3GNT5 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

B3GNT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTTGTAA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

B3GNT5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
AdiposeBody Subcutaneous White AdiposeAdipose
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See B3GNT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for B3GNT5

SOURCE GeneReport for Unigene cluster: Hs.718506

UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
Tissue specificity: Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and
cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus

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In Situ
Assay Products: 
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Orthologs
for B3GNT5 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for B3GNT5 gene from 4/14 species (see all 14)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves B3GNT51 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 75.65(n)
72.24(a)		   424960  NM_001113761.1  NP_001107233.1 
lizard
(Anolis carolinensis)		 Reptilia B3GNT56
 --
 72(a)
 1 ↔ 1
 3(54973-56118)
zebrafish
(Danio rerio)		 Actinopterygii b3gnt5a1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 60.89(n)
56.27(a)		   336526  NM_198876.1  NP_942577.1 
fruit fly
(Drosophila melanogaster)		 Insecta CG300366
CG300376
(see all 5)		 --
 21(a)
19(a)
(see all 5)		 many ↔ many
many ↔ many
(see all 5)		 2R(7865038-7866454)
2R(7866598-7867990)


ENSEMBL Gene Tree for B3GNT5 (if available)
TreeFam Gene Tree for B3GNT5 (if available) 

Paralogs
for B3GNT5 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for B3GNT5 gene
B3GNT32  B3GNT22  B3GALT52  B3GALT12  B3GNT42  B3GALT42  B3GNT72  B3GALT22  
B3GNT82  B3GNT62  B3GALNT12  B3GNT92  
10 SIMAP similar genes for B3GNT5 using alignment to 4 protein entries:     B3GN5_HUMAN (see all proteins):
B3GNT2    B3GALT5    B3GNT7    B3GALT2    B3GNT4    B3GALT1
B3GNT8    B3GNT6    B3GNT3    B3GNT9

B3GNT5 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for B3GNT5
PGOHUM00000236764


Genomic Variants
for B3GNT5 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GNT5
DNA2.0 Custom Variant and Variant Library Synthesis for B3GNT5

Disorders / Diseases
for B3GNT5 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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B3GNT5 for disorders           About MalaCards

B3GNT5 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: B3GNT5 (1 document)

Export disorders for B3GNT5 gene to outside databases

Publications
for B3GNT5 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for B3GNT5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with B3GNT5)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. (PubMed id 11283017)1, 2, 3 Togayachi A....Narimatsu H. (2001)
  2. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. (PubMed id 11384981)1, 2 Henion T.R.... Hennet T. (2001)
  3. High expression of lactotriaosylceramide, a differenti ation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients. (PubMed id 22411838)1 Wang Z....Li Y. (2012)
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
  5. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. (PubMed id 18483624)1 Marcos N.T....Reis C.A. (2008)
  6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

External Searches for B3GNT5 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing B3GNT5 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84002 HGNC: 15684 AceView: B3GNT5 Ensembl:ENSG00000176597 euGenes: HUgn84002
ECgene: B3GNT5 Kegg: 84002 H-InvDB: B3GNT5

Other Databases showing B3GNT5 gene

(According to HUGE)
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   --

Specialized Databases showing B3GNT5 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for B3GNT5 Pharmacogenomics, SNPs, Pathways
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT5
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_538

Intellectual Property
for B3GNT5 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for B3GNT5 gene:
Search GeneIP for patents involving B3GNT5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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