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Aliases for B3GNT5 Gene

Aliases for B3GNT5 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 5 2 3
  • UDP-GlcNAc:Beta-Gal Beta-1,3-N-Acetylglucosaminyltransferase 5 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase 5 3 4
  • Lactotriaosylceramide Synthase 3 4
  • Lc(3)Cer Synthase 3 4
  • Beta-1,3-Gn-T5 3 4
  • Lc3 Synthase 3 4
  • Beta3Gn-T5 3 4
  • BGnT-5 3 4
  • Lactosylceramide 1,3-N-Acetyl-Beta-D-Glucosaminyltransferase 2
  • Beta 1,3 N-Acetyglucosaminyltransferase Lc3 Synthase 3
  • Beta-1,3-N-Acetylglucosaminyltransferase BGnT-5 3
  • EC 2.4.1.206 4
  • EC 2.4.1 63
  • B3GN-T5 3

External Ids for B3GNT5 Gene

Previous GeneCards Identifiers for B3GNT5 Gene

  • GC03P179760
  • GC03P183826
  • GC03P184373
  • GC03P184291
  • GC03P184453
  • GC03P182971
  • GC03P180376

Summaries for B3GNT5 Gene

Entrez Gene Summary for B3GNT5 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT5 Gene

B3GNT5 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GALT2.

UniProtKB/Swiss-Prot for B3GNT5 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT5 Gene

Genomics for B3GNT5 Gene

Regulatory Elements for B3GNT5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for B3GNT5 Gene

Chromosome:
3
Start:
183,253,226 bp from pter
End:
183,298,504 bp from pter
Size:
45,279 bases
Orientation:
Plus strand

Genomic View for B3GNT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GNT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT5 Gene

Proteins for B3GNT5 Gene

  • Protein details for B3GNT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG0-B3GN5_HUMAN
    Recommended name:
    Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
    Protein Accession:
    Q9BYG0
    Secondary Accessions:
    • D3DNS5
    • Q59FE3
    • Q7L9Z5
    • Q8WWP9

    Protein attributes for B3GNT5 Gene

    Size:
    378 amino acids
    Molecular mass:
    44053 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92754.1; Type=Frameshift; Positions=347; Evidence={ECO:0000305};

neXtProt entry for B3GNT5 Gene

Proteomics data for B3GNT5 Gene at MOPED

Selected DME Specific Peptides for B3GNT5 Gene

Post-translational modifications for B3GNT5 Gene

  • Glycosylation at Asn 59
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT5 Gene

Domains & Families for B3GNT5 Gene

Gene Families for B3GNT5 Gene

Protein Domains for B3GNT5 Gene

Suggested Antigen Peptide Sequences for B3GNT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYG0

UniProtKB/Swiss-Prot:

B3GN5_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT5: view

Function for B3GNT5 Gene

Molecular function for B3GNT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development
UniProtKB/Swiss-Prot Induction:
Up-regulated by stimulation with retinoic acid and down-regulated with 12-O-tetradecanoylphorbol-13-acetate (TPA).

Enzyme Numbers (IUBMB) for B3GNT5 Gene

Gene Ontology (GO) - Molecular Function for B3GNT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity IDA 11384981
GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with B3GNT5: view
genes like me logo Genes that share phenotypes with B3GNT5: view

Animal Models for B3GNT5 Gene

MGI Knock Outs for B3GNT5:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GNT5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for B3GNT5 Gene

Localization for B3GNT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GNT5 Gene COMPARTMENTS Subcellular localization image for B3GNT5 gene
Compartment Confidence
golgi apparatus 4
nucleus 2

Gene Ontology (GO) - Cellular Components for B3GNT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IDA 11384981
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT5: view

Pathways & Interactions for B3GNT5 Gene

genes like me logo Genes that share pathways with B3GNT5: view

UniProtKB/Swiss-Prot Q9BYG0-B3GN5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GNT5 Gene

Gene Ontology (GO) - Biological Process for B3GNT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 11384981
GO:0006493 protein O-linked glycosylation TAS --
GO:0007417 central nervous system development IDA 11384981
GO:0009247 glycolipid biosynthetic process TAS 11384981
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with B3GNT5: view

No data available for SIGNOR curated interactions for B3GNT5 Gene

Drugs & Compounds for B3GNT5 Gene

(4) Drugs for B3GNT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Uridine 5'-diphosphate Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Agonist Endogenous agonist at S1P1-5 0

(463) Additional Compounds for B3GNT5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with B3GNT5: view

Transcripts for B3GNT5 Gene

Unigene Clusters for B3GNT5 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GNT5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - - - - - -
SP5: - - - - -

Relevant External Links for B3GNT5 Gene

GeneLoc Exon Structure for
B3GNT5
ECgene alternative splicing isoforms for
B3GNT5

Expression for B3GNT5 Gene

mRNA expression in normal human tissues for B3GNT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT5 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.3) and Muscle - Skeletal (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for B3GNT5 Gene



SOURCE GeneReport for Unigene cluster for B3GNT5 Gene Hs.718506

mRNA Expression by UniProt/SwissProt for B3GNT5 Gene

Q9BYG0-B3GN5_HUMAN
Tissue specificity: Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus.
genes like me logo Genes that share expression patterns with B3GNT5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for B3GNT5 Gene

Orthologs for B3GNT5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GNT5 35
  • 86.57 (n)
  • 87.06 (a)
B3GNT5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GNT5 35
  • 87.23 (n)
  • 86.44 (a)
B3GNT5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3gnt5 35
  • 84 (n)
  • 80 (a)
B3gnt5 16
B3gnt5 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B3GNT5 35
  • 99.69 (n)
  • 100 (a)
B3GNT5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3gnt5 35
  • 82.36 (n)
  • 80.05 (a)
oppossum
(Monodelphis domestica)
Mammalia B3GNT5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT5 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GNT5 35
  • 75.74 (n)
  • 72.24 (a)
B3GNT5 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B3GNT5 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt5 35
  • 68.72 (n)
  • 66.49 (a)
zebrafish
(Danio rerio)
Actinopterygii b3gnt5a 35
  • 60.98 (n)
  • 56.27 (a)
b3gnt5a 36
  • 56 (a)
OneToMany
b3gnt5b 36
  • 49 (a)
OneToMany
Species with no ortholog for B3GNT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT5 Gene

ENSEMBL:
Gene Tree for B3GNT5 (if available)
TreeFam:
Gene Tree for B3GNT5 (if available)

Paralogs for B3GNT5 Gene

(10) SIMAP similar genes for B3GNT5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for B3GNT5 Gene

genes like me logo Genes that share paralogs with B3GNT5: view

Variants for B3GNT5 Gene

Structural Variations from Database of Genomic Variants (DGV) for B3GNT5 Gene

Variant ID Type Subtype PubMed ID
esv2726288 CNV Deletion 23290073
esv2726289 CNV Deletion 23290073

Variation tolerance for B3GNT5 Gene

Residual Variation Intolerance Score: 47.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GNT5 Gene

HapMap Linkage Disequilibrium report
B3GNT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for B3GNT5 Gene

Disorders for B3GNT5 Gene

Relevant External Links for B3GNT5

Genetic Association Database (GAD)
B3GNT5
Human Genome Epidemiology (HuGE) Navigator
B3GNT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT5
genes like me logo Genes that share disorders with B3GNT5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT5 Gene

Publications for B3GNT5 Gene

  1. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. (PMID: 11283017) Togayachi A. … Narimatsu H. (J. Biol. Chem. 2001) 2 67
  2. High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients. (PMID: 22411838) Wang Z. … Li Y. (Glycobiology 2012) 67
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 67
  5. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. (PMID: 18483624) Marcos N.T. … Reis C.A. (J. Clin. Invest. 2008) 67

Products for B3GNT5 Gene

Sources for B3GNT5 Gene

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