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B3GNT5 Gene

protein-coding   GIFtS: 53
GCID: GC03P182971

UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 51 2     Beta 1,3 N-Acetyglucosaminyltransferase Lc3 Synthase2
Beta-1,3-N-Acetylglucosaminyltransferase 52 3     beta-1,3-Gn-T52
Lactotriaosylceramide Synthase2 3     Beta-1,3-N-Acetylglucosaminyltransferase BGnT-52
Lc(3)Cer Synthase2 3     beta3Gn-T52
Lc3 Synthase2 3     Lactosylceramide 1,3-N-Acetyl-Beta-D-Glucosaminyltransferase2
BGnT-52 3     Beta-1,3-Gn-T53
UDP-GlcNAc:Beta-Gal Beta-1,3-N-Acetylglucosaminyltransferase 52 3     Beta3Gn-T53
3-N-acetyl-beta-D-glucosaminyltransferase1     EC 2.4.1.2063
Lactosylceramide 11     EC 2.4.18
B3GN-T52     

External Ids:    HGNC: 156841   Entrez Gene: 840022   Ensembl: ENSG000001765977   OMIM: 6153335   UniProtKB: Q9BYG03   
ORGUL members:         

Export aliases for B3GNT5 gene to outside databases

Previous GC identifers: GC03P179760 GC03P183826 GC03P184373 GC03P184291 GC03P184453 GC03P180376


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for B3GNT5 Gene:
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II
membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as
the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of
Lewis X epitopes on glycolipids. (provided by RefSeq, Jul 2008)

GeneCards Summary for B3GNT5 Gene:
B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5) is a protein-coding gene. Diseases associated with B3GNT5 include acute myeloid leukemia, and myeloid leukemia. GO annotations related to this gene include galactosyltransferase activity and lipopolysaccharide N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT3.

UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or
neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X
carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide
(nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer),
respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic
development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the B3GNT5 gene promoter:
         Pbx1a   AML1a   Lmo2   RelA   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   RORalpha1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GNT5 promoter sequence
   Search Chromatin IP Primers for B3GNT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B3GNT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q28

B3GNT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GNT5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P182971:  view genomic region     (about GC identifiers)

Start:
182,971,032 bp from pter      End:
183,016,292 bp from pter
Size:
45,261 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0 (See protein sequence)
Recommended Name: Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase  
Size: 378 amino acids; 44053 Da
Sequence caution: Sequence=BAD92754.1; Type=Frameshift; Positions=347;
Secondary accessions: D3DNS5 Q59FE3 Q7L9Z5 Q8WWP9

Explore the universe of human proteins at neXtProt for B3GNT5: NX_Q9BYG0

Explore proteomics data for B3GNT5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for B3GNT5 (Q9BYG0) (see all 7)
     MMTSHGH  PYHPCIY  YIDDVFMG  KSYSYRYL 


    See B3GNT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114436.1  
    ENSEMBL proteins: 
     ENSP00000316173   ENSP00000418785   ENSP00000420778   ENSP00000418477   ENSP00000417868  
     ENSP00000417301  
    Reactome Protein details: Q9BYG0

    B3GNT5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases

    1 InterPro protein domain:
     IPR002659 Glyco_trans_31

    Graphical View of Domain Structure for InterPro Entry Q9BYG0

    ProtoNet protein and cluster: Q9BYG0

    1 Blocks protein domain: IPB002659 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
    Similarity: Belongs to the glycosyltransferase 31 family


    B3GNT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3GN5_HUMAN, Q9BYG0
    Function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or
    neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X
    carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide
    (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer),
    respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic
    development
    Catalytic activity: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP +
    N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
    Induction: Up-regulated by stimulation with retinoic acid and down-regulated with
    12-O-tetradecanoylphorbol-13-acetate (TPA)

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.2061

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity IEA--
    GO:0008457beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity IDA11384981
    GO:0008917lipopolysaccharide N-acetylglucosaminyltransferase activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0047256lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity IEA--
         
    B3GNT5 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for B3gnt5):
     growth/size/body  hematopoietic system  immune system  mortality/aging  no phenotypic analysis 
     reproductive system 

    B3GNT5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for B3GNT5: B3gnt5tm1.1Cfg B3gnt5tm1Nari B3gnt5tm1Then B3gnt5tm2.1Big B3gnt5tm1Big

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B3GNT5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for B3GNT5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for B3GNT5

    miRNA
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    miRTarBase miRNAs that target B3GNT5:
    hsa-mir-21-5p (MIRT031039), hsa-mir-215-5p (MIRT024816), hsa-mir-192-5p (MIRT026906), hsa-mir-30b-5p (MIRT023460), hsa-mir-10a-5p (MIRT047723), hsa-mir-335-5p (MIRT019068), hsa-mir-30c-5p (MIRT047995)

    Block miRNA regulation of human, mouse, rat B3GNT5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate B3GNT5 (see all 32):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-944 hsa-miR-30d hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidB3GNT5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat B3GNT5

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for B3GNT5 (see all 9)
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    GenScript: all cDNA clones in your preferred vector: B3GNT5 (NM_032047)
    Sino Biological Human cDNA Clone for B3GNT5
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GNT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B3GN5_HUMAN, Q9BYG0: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular IDA11384981
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    B3GNT5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for B3GNT5 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    2O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    3Metabolism
    Metabolic pathways0.38
    4Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for B3GNT5
        O-linked glycosylation of mucins


    2 Kegg Pathways  (Kegg details for B3GNT5):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
    Pathway: Protein modification; protein glycosylation


    B3GNT5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for B3GNT5
    Interactions:

        Search GeneGlobe Interaction Network for B3GNT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for B3GNT5 (ENSP000003161734) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT2ENSP000003564044STRING: ENSP00000356404
    B3GALT1ENSP000003037404STRING: ENSP00000303740
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS11384981
    GO:0007417central nervous system development IDA11384981
    GO:0009247glycolipid biosynthetic process TAS11384981
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--

    B3GNT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for B3GNT5 (B3GN5)

    Selected HMDB Compounds for B3GNT5 (see all 521)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for B3GNT5 gene: 
    NM_032047.4  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326505(uc003flk.3 uc003fll.3 uc003flm.3) ENST00000493370
    ENST00000480551 ENST00000464191 ENST00000460419 ENST00000464923 ENST00000496270
    ENST00000465010 ENST00000488301 ENST00000477699 ENST00000481531 ENST00000462559(uc003fln.1)

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    Selected qRT-PCR Assays for microRNAs that regulate B3GNT5 (see all 32):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-944 hsa-miR-30d hsa-miR-1297
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    Primer
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    OriGene qPCR primer pairs and template standards for B3GNT5
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      QuantiTect SYBR Green Assays in human, mouse, rat B3GNT5
      QuantiFast Probe-based Assays in human, mouse, rat B3GNT5

    Selected AceView cDNA sequences (see all 123):

    AI467964 AW516070 AK074424 BM142526 BX499010 CB163019 D81847 AB045278 
    AW662544 AK126337 BF223815 AK074235 CD678910 BM142352 BF109408 BF940440 
    AW452443 AK091474 AW026723 AX747008 NM_032047 BC028058 BQ722475 BU684277 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT5    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                                                  
    SP2:                                -                                 
    SP3:                          -     -                                 
    SP4:        -     -     -     -     -     -                           
    SP5:              -     -     -     -     -                           


    ECgene alternative splicing isoforms for B3GNT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    B3GNT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCTTGTAA
    B3GNT5 Expression
    About this image


    B3GNT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Lens
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Brain (Nervous System)
             Cerebellum
     
     Colon (Gastrointestinal Tract)
    B3GNT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    B3GNT5 Protein Expression

    UniProtKB/Swiss-Prot: B3GN5_HUMAN, Q9BYG0
    Tissue specificity: Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and
    cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for B3GNT5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B3gnt51 , 5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more1, 5 84(n)1
    80(a)1
      16 (12.23 cM)5
    1081051  NM_001159407.11  NP_001152879.11 
     197602085 
    chicken
    (Gallus gallus)
    Aves B3GNT51 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 75.74(n)
    72.24(a)
      424960  NM_001113761.1  NP_001107233.1 
    lizard
    (Anolis carolinensis)
    Reptilia B3GNT56
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltr...
    71(a)
    1 ↔ 1
    3(54973-56118)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia b3gnt51 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 68.72(n)
    66.49(a)
      394849  NM_203909.1  NP_989240.1 
    zebrafish
    (Danio rerio)
    Actinopterygii b3gnt5a1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase more 60.98(n)
    56.27(a)
      336526  NM_198876.1  NP_942577.1 


    ENSEMBL Gene Tree for B3GNT5 (if available)
    TreeFam Gene Tree for B3GNT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for B3GNT5 gene
    B3GNT32  B3GNT22  B3GALT52  B3GALT12  B3GNT42  B3GALT42  B3GALT22  B3GNT72  
    B3GNT82  B3GNT62  B3GALNT12  B3GNT92  
    10 SIMAP similar genes for B3GNT5 using alignment to 4 protein entries:     B3GN5_HUMAN (see all proteins):
    B3GNT2    B3GALT5    B3GNT7    B3GALT2    B3GNT4    B3GALT1
    B3GNT6    B3GNT8    B3GNT3    B3GNT9

    B3GNT5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for B3GNT5
    PGOHUM00000236764


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for B3GNT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726289CNV Deletion23290073
    esv2726288CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615333    OMIM disorders: --

    3 diseases for B3GNT5:    
    About MalaCards
    acute myeloid leukemia    myeloid leukemia    leukemia


    B3GNT5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): B3GNT5
    Human Genome Epidemiology (HuGE) Navigator: B3GNT5 (1 document)

    Export disorders for B3GNT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for B3GNT5 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with B3GNT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. (PubMed id 11283017)1, 2, 3 Togayachi A....Narimatsu H. (J. Biol. Chem. 2001)
    2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    3. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. (PubMed id 11384981)1, 2 Henion T.R.... Hennet T. (J. Biol. Chem. 2001)
    4. High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients. (PubMed id 22411838)1 Wang Z....Li Y. (Glycobiology 2012)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. (PubMed id 18483624)1 Marcos N.T....Reis C.A. (J. Clin. Invest. 2008)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84002 HGNC: 15684 AceView: B3GNT5 Ensembl:ENSG00000176597 euGenes: HUgn84002
    ECgene: B3GNT5 Kegg: 84002 H-InvDB: B3GNT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for B3GNT5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_538

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for B3GNT5 gene:
    Search GeneIP for patents involving B3GNT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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