Aliases for B3GNT4 Gene
Aliases for B3GNT4 Gene
- UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4 2 3 4 5
- Beta-1,3-N-Acetylglucosaminyltransferase 4 3 4
- Beta-1,3-Gn-T4 3 4
- Beta3Gn-T4 3 4
- BGnT-4 3 4
- N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 4 3
- Beta-1,3-N-Acetylglucosaminyltransferase BGn-T4 3
- EC 2.4.1.149 4
- B3GN-T4 3
External Ids for B3GNT4 Gene
- HGNC: 15683
- Entrez Gene: 79369
- Ensembl: ENSG00000176383
- OMIM: 605864
- UniProtKB: Q9C0J1
Previous GeneCards Identifiers for B3GNT4 Gene
- GC12M121471
- GC12M122667
- GC12P122496
- GC12P121125
- GC12P121212
- GC12P122689
- GC12P119649
Summaries for B3GNT4 Gene
-
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for B3GNT4 Gene
B3GNT4 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and O-linked glycosylation. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT7.
UniProtKB/Swiss-Prot for B3GNT4 Gene
-
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT4 Gene
Genomics for B3GNT4 Gene
Regulatory Elements for B3GNT4 Gene
- Transcription factor binding sites by QIAGEN in the B3GNT4 gene promoter:
Regulatory Element Products
Genomic Location for B3GNT4 Gene
- Chromosome:
- 12
- Start:
- 122,203,543 bp from pter
- End:
- 122,208,952 bp from pter
- Size:
- 5,410 bases
- Orientation:
- Plus strand
Genomic View for B3GNT4 Gene
- Cytogenetic band:
-
- 12q24.31 by Ensembl
- 12q24.31 by Entrez Gene
- 12q24.31 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for B3GNT4 Gene
Proteins for B3GNT4 Gene
-
Protein details for B3GNT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0J1-B3GN4_HUMAN
- Recommended name:
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4
- Protein Accession:
- Q9C0J1
- Q8N5W4
- Q8N934
- Q8ND21
- Q8WWR5
- Q8WY02
- Q96QH5
Protein attributes for B3GNT4 Gene
- Size:
- 378 amino acids
- Molecular mass:
- 42310 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAL37219.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for B3GNT4 Gene
Other Protein References for B3GNT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for B3GNT4
- Novus Biologicals Antibodies for B3GNT4
-
Abcam antibodies for B3GNT4
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Protein Products
- R&D Systems Proteins and Enzymes for B3GNT4 ("Beta-1,3-N-Acetylglucosaminyltransferase 4/B3GNT4")
-
OriGene Purified Proteins for B3GNT4
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- Search GeneTex for Proteins for B3GNT4
-
Abcam proteins for B3GNT4
Assay Products
No data available for DME Specific Peptides for B3GNT4 Gene
Domains & Families for B3GNT4 Gene
Gene Families for B3GNT4 Gene
Protein Domains for B3GNT4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for B3GNT4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9C0J1- Family:
-
- Belongs to the glycosyltransferase 31 family.
Function for B3GNT4 Gene
Molecular function for B3GNT4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
- UniProtKB/Swiss-Prot Function:
- Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.
Enzyme Numbers (IUBMB) for B3GNT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008378 | galactosyltransferase activity | IEA | -- |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | TAS | -- |
| GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for B3GNT4 Gene
- GenomeRNAi human phenotypes for B3GNT4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased G1 DNA content
- G0/1 arrest
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased homologous recombination repair frequency
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for B3GNT4 gene
-
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- Search ViGene Biosciences for B3GNT4
CRISPR Products
-
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-
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miRNA for B3GNT4 Gene
- miRTarBase miRNAs that target B3GNT4
miRNA Products
- Search ViGene Biosciences for B3GNT4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for B3GNT4
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for B3GNT4
-
ViGene Biosciences adenoviral particle packaged cDNA for B3GNT4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for B3GNT4 gene
-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT4 Gene
Localization for B3GNT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for B3GNT4 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for B3GNT4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Keratan sulfate/keratin metabolism | ||
| 4 | Metabolism of proteins | ||
| 5 | O-linked glycosylation | ||
Pathways by source for B3GNT4 Gene
9 Reactome pathways for B3GNT4 Gene
2 KEGG pathways for B3GNT4 Gene
UniProtKB/Swiss-Prot Q9C0J1-B3GN4_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for B3GNT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0018146 | keratan sulfate biosynthetic process | TAS | -- |
| GO:0030311 | poly-N-acetyllactosamine biosynthetic process | IDA | 11042166 |
No data available for SIGNOR curated interactions for B3GNT4 Gene
Transcripts for B3GNT4 Gene
mRNA/cDNA for B3GNT4 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (39) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for B3GNT4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT4
- GenScript: Design CRISPR guide RNA sequences for B3GNT4
miRNA Products
- Search ViGene Biosciences for B3GNT4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for B3GNT4
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-
ViGene Biosciences ready-to-package AAV shRNAs for B3GNT4 gene
Clone Products
-
OriGene ORF clones in human for B3GNT4
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- VectorBuilder custom plasmid, inducible vectors for B3GNT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for B3GNT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
-
Gonad
- Secondary Oocyte Antral Follicle
mRNA differential expression in normal tissues according to GTEx for B3GNT4 Gene
NURSA nuclear receptor signaling pathways regulating expression of B3GNT4 Gene:
B3GNT4SOURCE GeneReport for Unigene cluster for B3GNT4 Gene:
Hs.363315mRNA Expression by UniProt/SwissProt for B3GNT4 Gene:
Q9C0J1-B3GN4_HUMANEvidence on tissue expression from TISSUES for B3GNT4 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for B3GNT4
-
OriGene qPCR primer pairs and template standards for B3GNT4
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT4 Gene
Orthologs for B3GNT4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | B3GNT4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | B3GNT4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | B3GNT4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | B3gnt4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | B3gnt4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | B3GNT4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | B3GNT4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | B3GNT4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | B3GNT4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | b3gnt4 34 |
|
||
| Str.20273 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | b3gnt7l 35 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG30036 34 |
|
- Species where no ortholog for B3GNT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for B3GNT4 Gene
Paralogs for B3GNT4 Gene
(8) SIMAP similar genes for B3GNT4 Gene using alignment to 1 proteins:
Variants for B3GNT4 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519151 | Uncertain significance | 122,208,389(-) | GAGGC(-/CTACCTGCGTG)AGGAT | downstream-variant-500B, reference, utr-variant-3-prime, frameshift-variant | |
| rs150199226 | Benign | 122,208,431(+) | CTCCC(C/T)TTCCT | downstream-variant-500B, reference, missense, utr-variant-3-prime | |
| rs35426428 | Benign | 122,208,411(+) | TGCTC(C/T)GACTC | downstream-variant-500B, reference, synonymous-codon, utr-variant-3-prime | |
| rs1000342979 | -- | 122,203,752(+) | TCCGC(C/T)CTGGC | intron-variant, downstream-variant-500B, utr-variant-5-prime | |
| rs1000839607 | -- | 122,203,989(+) | GGGCC(C/T)ACGGG | intron-variant |
Relevant External Links for B3GNT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- B3GNT4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for B3GNT4 Gene
Disorders for B3GNT4 Gene
Relevant External Links for B3GNT4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- B3GNT4
No disorders were found for B3GNT4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT4 Gene
Publications for B3GNT4 Gene
- Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PMID: 10580128) Amado M. … Clausen H. (Biochim. Biophys. Acta 1999) 3 4 64
- Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3 64
Products for B3GNT4 Gene
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- OriGene qPCR primer pairs and template standards for B3GNT4
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- Novus Biologicals Antibodies for B3GNT4
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- Abcam antibodies for B3GNT4
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- Search for Assays for B3GNT4 at Abcam
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- ViGene Biosciences adenoviral particle packaged cDNA for B3GNT4 gene
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- Horizon Cell Lines for B3GNT4
- Cyagen custom Knockout/knockin (KOKI) mouse models for B3GNT4
- VectorBuilder custom plasmid, inducible vectors for B3GNT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for B3GNT4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




