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Aliases for B3GNT4 Gene

Aliases for B3GNT4 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4 2 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase 4 3 4
  • Beta-1,3-Gn-T4 3 4
  • Beta3Gn-T4 3 4
  • BGnT-4 3 4
  • N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 4 3
  • Beta-1,3-N-Acetylglucosaminyltransferase BGn-T4 3
  • EC 2.4.1.149 4
  • B3GN-T4 3

External Ids for B3GNT4 Gene

Summaries for B3GNT4 Gene

Entrez Gene Summary for B3GNT4 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT4 Gene

B3GNT4 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4) is a Protein Coding gene. Diseases associated with B3GNT4 include mucopolysaccharidoses. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT4 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT4 Gene

Genomics for B3GNT4 Gene

Genomic Location for B3GNT4 Gene

Start:
122,203,543 bp from pter
End:
122,208,952 bp from pter
Size:
5,410 bases
Orientation:
Plus strand

Genomic View for B3GNT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT4 Gene

Regulatory Elements for B3GNT4 Gene

Proteins for B3GNT4 Gene

  • Protein details for B3GNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0J1-B3GN4_HUMAN
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4
    Protein Accession:
    Q9C0J1
    Secondary Accessions:
    • Q8N5W4
    • Q8N934
    • Q8ND21
    • Q8WWR5
    • Q8WY02
    • Q96QH5

    Protein attributes for B3GNT4 Gene

    Size:
    378 amino acids
    Molecular mass:
    42310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL37219.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for B3GNT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for B3GNT4 Gene

Proteomics data for B3GNT4 Gene at MOPED

Post-translational modifications for B3GNT4 Gene

Other Protein References for B3GNT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT4 Gene

Domains for B3GNT4 Gene

Gene Families for B3GNT4 Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GNT4 Gene

UniProtKB/Swiss-Prot:

B3GN4_HUMAN
Family:
  • Belongs to the glycosyltransferase 31 family.:
    • Q9C0J1
genes like me logo Genes that share domains with B3GNT4: view

Function for B3GNT4 Gene

Molecular function for B3GNT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.

Enzyme Numbers (IUBMB) for B3GNT4 Gene

Gene Ontology (GO) - Molecular Function for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IDA 11042166
GO:0016757 transferase activity, transferring glycosyl groups --
genes like me logo Genes that share ontologies with B3GNT4: view

Phenotypes for B3GNT4 Gene

GenomeRNAi human phenotypes for B3GNT4:
genes like me logo Genes that share phenotypes with B3GNT4: view

miRNA for B3GNT4 Gene

miRTarBase miRNAs that target B3GNT4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for B3GNT4 Gene

Localization for B3GNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GNT4 Gene COMPARTMENTS Subcellular localization image for B3GNT4 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT4: view

Pathways for B3GNT4 Gene

genes like me logo Genes that share pathways with B3GNT4: view

UniProtKB/Swiss-Prot Q9C0J1-B3GN4_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GNT4 Gene

Gene Ontology (GO) - Biological Process for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with B3GNT4: view

Transcripts for B3GNT4 Gene

Unigene Clusters for B3GNT4 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT4 Gene

No ASD Table

Relevant External Links for B3GNT4 Gene

GeneLoc Exon Structure for
B3GNT4
ECgene alternative splicing isoforms for
B3GNT4

Expression for B3GNT4 Gene

mRNA expression in normal human tissues for B3GNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.6), Brain - Cortex (5.5), and Brain - Hippocampus (4.7).

SOURCE GeneReport for Unigene cluster for B3GNT4 Gene Hs.363315

mRNA Expression by UniProt/SwissProt for B3GNT4 Gene

Q9C0J1-B3GN4_HUMAN
Tissue specificity: Mainly expressed in brain tissues such as whole brain, hippocampus, amygdala, cerebellum and caudate nucleus. Also expressed in colon, esophagus and kidney.
genes like me logo Genes that share expressions with B3GNT4: view

Orthologs for B3GNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B3GNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT4 36
  • 98.77 (n)
  • 98.15 (a)
B3GNT4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia B3GNT4 36
  • 85.32 (n)
  • 85.51 (a)
B3GNT4 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GNT4 36
  • 86.17 (n)
  • 88.07 (a)
B3GNT4 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3gnt4 36
  • 80.98 (n)
  • 80.06 (a)
B3gnt4 16
B3gnt4 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia B3GNT4 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT4 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3gnt4 36
  • 82.71 (n)
  • 81.99 (a)
chicken
(Gallus gallus)
Aves B3GNT4 36
  • 65.63 (n)
  • 60.99 (a)
B3GNT4 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B3GNT4 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt4 36
  • 61.66 (n)
  • 59.74 (a)
Str.20273 36
zebrafish
(Danio rerio)
Actinopterygii b3gnt7l 37
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30036 36
  • 45.93 (n)
  • 33.59 (a)
Species with no ortholog for B3GNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT4 Gene

ENSEMBL:
Gene Tree for B3GNT4 (if available)
TreeFam:
Gene Tree for B3GNT4 (if available)

Paralogs for B3GNT4 Gene

Selected SIMAP similar genes for B3GNT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT4: view

Variants for B3GNT4 Gene

Sequence variations from dbSNP and Humsavar for B3GNT4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs879132 -- 122,204,233(-) CTCGG(A/G)TCCCC intron-variant
rs1001178 - 122,206,498(-) GCTAG(A/T)CACTG missense, reference
rs7136356 - 122,204,634(+) CCCAG(C/G)CTTCC reference, missense
rs7304287 -- 122,204,948(+) tcgct(G/T)gaacc intron-variant
rs7484523 -- 122,204,297(+) GGGTC(A/G)TGCGC intron-variant

Relevant External Links for B3GNT4 Gene

HapMap Linkage Disequilibrium report
B3GNT4

No data available for Structural Variations from Database of Genomic Variants (DGV) for B3GNT4 Gene

Disorders for B3GNT4 Gene

(1) MalaCards Diseases for B3GNT4 Gene

Search for B3GNT4 Gene in MalaCards »
genes like me logo Genes that share disorders with B3GNT4: view

No data available for UniProtKB/Swiss-Prot for B3GNT4 Gene

Publications for B3GNT4 Gene

  1. Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4
  2. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PMID: 10580128) Amado M. … Clausen H. (Biochim. Biophys. Acta 1999) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for B3GNT4 Gene

Sources for B3GNT4 Gene

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