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Aliases for B3GNT4 Gene

Aliases for B3GNT4 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4 2 3 4 5
  • Beta-1,3-N-Acetylglucosaminyltransferase 4 3 4
  • Beta-1,3-Gn-T4 3 4
  • Beta3Gn-T4 3 4
  • BGnT-4 3 4
  • N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 4 3
  • Beta-1,3-N-Acetylglucosaminyltransferase BGn-T4 3
  • EC 2.4.1.149 4
  • B3GN-T4 3

External Ids for B3GNT4 Gene

Previous GeneCards Identifiers for B3GNT4 Gene

  • GC12M121471
  • GC12M122667
  • GC12P122496
  • GC12P121125
  • GC12P121212
  • GC12P122689
  • GC12P119649

Summaries for B3GNT4 Gene

Entrez Gene Summary for B3GNT4 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT4 Gene

B3GNT4 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of proteins. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT9.

UniProtKB/Swiss-Prot for B3GNT4 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT4 Gene

Genomics for B3GNT4 Gene

Regulatory Elements for B3GNT4 Gene

Enhancers for B3GNT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F122085 1.4 Ensembl ENCODE 11.3 -109.1 -109060 17.2 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZCCHC8 ENSG00000272849 LINC01089 SETD1B MLXIP LOC100506691 ARL6IP4 ANAPC5 LRRC43 B3GNT4
GH12F122054 1.2 Ensembl ENCODE 11.7 -148.2 -148150 2.4 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 ZNF143 LOC101928346 LOC100506691 LRRC43 B3GNT4 DIABLO MLXIP ENSG00000255856
GH12F122050 1.2 Ensembl ENCODE 11.4 -152.2 -152159 1.5 ARNT MLX ARID4B YY1 GLIS2 GATA2 SP5 NFYC PPARG KAT8 BCL7A ENSG00000255856 LRRC43 B3GNT4 DIABLO MLXIP LOC100506691
GH12F121982 1.3 Ensembl ENCODE 10.5 -219.9 -219943 1.6 PKNOX1 ARID4B SIN3A ZNF121 GLIS2 ZNF766 ZNF207 ZNF263 REST TSHZ1 WDR66 ENSG00000255856 BCL7A RNU7-170P PSMD9 ENSG00000256950 HPD LRRC43 B3GNT4 ZCCHC8
GH12F122104 1.1 Ensembl ENCODE 12.3 -94.1 -94073 10.9 PKNOX1 FEZF1 ZBTB40 RARA ZNF121 FOS SP5 CEBPB ZEB2 SREBF1 MLXIP LOC100506691 LRRC43 B3GNT4 IL31 RNU7-170P PSMD9 ENSG00000256950 HPD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B3GNT4 on UCSC Golden Path with GeneCards custom track

Promoters for B3GNT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000438457 257 1201 ZNF76 KLF17 ZNF121 GLIS2 EGR1 SCRT2 EGR2 SP3 ZBTB2 REST

Genomic Location for B3GNT4 Gene

Chromosome:
12
Start:
122,203,543 bp from pter
End:
122,208,952 bp from pter
Size:
5,410 bases
Orientation:
Plus strand

Genomic View for B3GNT4 Gene

Genes around B3GNT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT4 Gene

Proteins for B3GNT4 Gene

  • Protein details for B3GNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0J1-B3GN4_HUMAN
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4
    Protein Accession:
    Q9C0J1
    Secondary Accessions:
    • Q8N5W4
    • Q8N934
    • Q8ND21
    • Q8WWR5
    • Q8WY02
    • Q96QH5

    Protein attributes for B3GNT4 Gene

    Size:
    378 amino acids
    Molecular mass:
    42310 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL37219.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for B3GNT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for B3GNT4 Gene

Post-translational modifications for B3GNT4 Gene

  • Glycosylation at Asn 192
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT4 Gene

No data available for DME Specific Peptides for B3GNT4 Gene

Domains & Families for B3GNT4 Gene

Gene Families for B3GNT4 Gene

Protein Domains for B3GNT4 Gene

Suggested Antigen Peptide Sequences for B3GNT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0J1

UniProtKB/Swiss-Prot:

B3GN4_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT4: view

Function for B3GNT4 Gene

Molecular function for B3GNT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.

Enzyme Numbers (IUBMB) for B3GNT4 Gene

Gene Ontology (GO) - Molecular Function for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS --
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GNT4: view
genes like me logo Genes that share phenotypes with B3GNT4: view

Animal Model Products

miRNA for B3GNT4 Gene

miRTarBase miRNAs that target B3GNT4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT4 Gene

Localization for B3GNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B3GNT4 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GNT4: view

Pathways & Interactions for B3GNT4 Gene

genes like me logo Genes that share pathways with B3GNT4: view

UniProtKB/Swiss-Prot Q9C0J1-B3GN4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030311 poly-N-acetyllactosamine biosynthetic process IDA 11042166
genes like me logo Genes that share ontologies with B3GNT4: view

No data available for SIGNOR curated interactions for B3GNT4 Gene

Transcripts for B3GNT4 Gene

Unigene Clusters for B3GNT4 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT4 Gene

No ASD Table

Relevant External Links for B3GNT4 Gene

GeneLoc Exon Structure for
B3GNT4
ECgene alternative splicing isoforms for
B3GNT4

Expression for B3GNT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for B3GNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.5), and Brain - Hippocampus (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of B3GNT4 Gene:

B3GNT4

SOURCE GeneReport for Unigene cluster for B3GNT4 Gene:

Hs.363315

mRNA Expression by UniProt/SwissProt for B3GNT4 Gene:

Q9C0J1-B3GN4_HUMAN
Tissue specificity: Mainly expressed in brain tissues such as whole brain, hippocampus, amygdala, cerebellum and caudate nucleus. Also expressed in colon, esophagus and kidney.
genes like me logo Genes that share expression patterns with B3GNT4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for B3GNT4 Gene

Orthologs for B3GNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B3GNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GNT4 34 35
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia B3GNT4 34 35
  • 86.17 (n)
cow
(Bos Taurus)
Mammalia B3GNT4 34 35
  • 85.32 (n)
rat
(Rattus norvegicus)
Mammalia B3gnt4 34
  • 82.71 (n)
mouse
(Mus musculus)
Mammalia B3gnt4 34 16 35
  • 80.98 (n)
oppossum
(Monodelphis domestica)
Mammalia B3GNT4 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT4 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GNT4 34 35
  • 65.63 (n)
lizard
(Anolis carolinensis)
Reptilia B3GNT4 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt4 34
  • 61.66 (n)
Str.20273 34
zebrafish
(Danio rerio)
Actinopterygii b3gnt7l 35
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30036 34
  • 45.93 (n)
Species where no ortholog for B3GNT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT4 Gene

ENSEMBL:
Gene Tree for B3GNT4 (if available)
TreeFam:
Gene Tree for B3GNT4 (if available)

Paralogs for B3GNT4 Gene

(8) SIMAP similar genes for B3GNT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT4: view

Variants for B3GNT4 Gene

Sequence variations from dbSNP and Humsavar for B3GNT4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35426428 Benign 122,208,411(+) TGCTC(C/T)GACTC downstream-variant-500B, reference, synonymous-codon, utr-variant-3-prime
rs1001178 -- 122,206,498(-) GCTAG(A/G/T)CACTG reference, missense
rs10848035 -- 122,201,890(+) GCACT(G/T)TGGCG intron-variant, upstream-variant-2KB
rs11060802 -- 122,202,460(+) tatat(G/T)gaatt intron-variant, upstream-variant-2KB
rs11061130 -- 122,207,414(+) CTGAG(A/G)GTGGA downstream-variant-500B, utr-variant-3-prime

Variation tolerance for B3GNT4 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.32; 90.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GNT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
B3GNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for B3GNT4 Gene

Disorders for B3GNT4 Gene

Relevant External Links for B3GNT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GNT4

No disorders were found for B3GNT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT4 Gene

Publications for B3GNT4 Gene

  1. Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PMID: 10580128) Amado M. … Clausen H. (Biochim. Biophys. Acta 1999) 3 4 64
  5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3 64

Products for B3GNT4 Gene

Sources for B3GNT4 Gene

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