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Aliases for B3GNT4 Gene

Aliases for B3GNT4 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4 2 3 4 5
  • Beta-1,3-N-Acetylglucosaminyltransferase 4 3 4
  • Beta-1,3-Gn-T4 3 4
  • Beta3Gn-T4 3 4
  • BGnT-4 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase BGn-T4 3
  • EC 4
  • B3GN-T4 3

External Ids for B3GNT4 Gene

Previous GeneCards Identifiers for B3GNT4 Gene

  • GC12M121471
  • GC12M122667
  • GC12P122496
  • GC12P121125
  • GC12P121212
  • GC12P122689
  • GC12P119649

Summaries for B3GNT4 Gene

Entrez Gene Summary for B3GNT4 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT4 Gene

B3GNT4 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Keratan sulfate/keratin metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT4 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT4 Gene

Genomics for B3GNT4 Gene

Regulatory Elements for B3GNT4 Gene

Enhancers for B3GNT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B3GNT4 on UCSC Golden Path with GeneCards custom track

Promoters for B3GNT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B3GNT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GNT4 Gene

122,203,543 bp from pter
122,208,952 bp from pter
5,410 bases
Plus strand

Genomic View for B3GNT4 Gene

Genes around B3GNT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GNT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT4 Gene

Proteins for B3GNT4 Gene

  • Protein details for B3GNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4
    Protein Accession:
    Secondary Accessions:
    • Q8N5W4
    • Q8N934
    • Q8ND21
    • Q8WWR5
    • Q8WY02
    • Q96QH5

    Protein attributes for B3GNT4 Gene

    378 amino acids
    Molecular mass:
    42310 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL37219.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for B3GNT4 Gene


neXtProt entry for B3GNT4 Gene

Proteomics data for B3GNT4 Gene at MOPED

Post-translational modifications for B3GNT4 Gene

  • Glycosylation at Asn 192
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B3GNT4 Gene

Domains & Families for B3GNT4 Gene

Gene Families for B3GNT4 Gene

Protein Domains for B3GNT4 Gene

Suggested Antigen Peptide Sequences for B3GNT4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 31 family.
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT4: view

Function for B3GNT4 Gene

Molecular function for B3GNT4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides.

Enzyme Numbers (IUBMB) for B3GNT4 Gene

genes like me logo Genes that share phenotypes with B3GNT4: view

Animal Model Products

miRNA for B3GNT4 Gene

miRTarBase miRNAs that target B3GNT4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B3GNT4 Gene

Localization for B3GNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for B3GNT4 Gene COMPARTMENTS Subcellular localization image for B3GNT4 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for B3GNT4 Gene

Pathways & Interactions for B3GNT4 Gene

genes like me logo Genes that share pathways with B3GNT4: view

UniProtKB/Swiss-Prot Q9C0J1-B3GN4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GNT4 Gene

Gene Ontology (GO) - Biological Process for B3GNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0042339 keratan sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with B3GNT4: view

No data available for SIGNOR curated interactions for B3GNT4 Gene

Drugs & Compounds for B3GNT4 Gene

No Compound Related Data Available

Transcripts for B3GNT4 Gene

Unigene Clusters for B3GNT4 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT4 Gene

No ASD Table

Relevant External Links for B3GNT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B3GNT4 Gene

mRNA expression in normal human tissues for B3GNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.5), and Brain - Hippocampus (x4.7).

SOURCE GeneReport for Unigene cluster for B3GNT4 Gene Hs.363315

mRNA Expression by UniProt/SwissProt for B3GNT4 Gene

Tissue specificity: Mainly expressed in brain tissues such as whole brain, hippocampus, amygdala, cerebellum and caudate nucleus. Also expressed in colon, esophagus and kidney.
genes like me logo Genes that share expression patterns with B3GNT4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for B3GNT4 Gene

Orthologs for B3GNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for B3GNT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia B3GNT4 35
  • 85.32 (n)
  • 85.51 (a)
B3GNT4 36
  • 83 (a)
(Canis familiaris)
Mammalia B3GNT4 35
  • 86.17 (n)
  • 88.07 (a)
B3GNT4 36
  • 89 (a)
(Mus musculus)
Mammalia B3gnt4 35
  • 80.98 (n)
  • 80.06 (a)
B3gnt4 16
B3gnt4 36
  • 78 (a)
(Pan troglodytes)
Mammalia B3GNT4 35
  • 98.77 (n)
  • 98.15 (a)
B3GNT4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia B3gnt4 35
  • 82.71 (n)
  • 81.99 (a)
(Monodelphis domestica)
Mammalia B3GNT4 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia B3GNT4 36
  • 66 (a)
(Gallus gallus)
Aves B3GNT4 35
  • 65.63 (n)
  • 60.99 (a)
B3GNT4 36
  • 55 (a)
(Anolis carolinensis)
Reptilia B3GNT4 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt4 35
  • 61.66 (n)
  • 59.74 (a)
Str.20273 35
(Danio rerio)
Actinopterygii b3gnt7l 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30036 35
  • 45.93 (n)
  • 33.59 (a)
Species with no ortholog for B3GNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT4 Gene

Gene Tree for B3GNT4 (if available)
Gene Tree for B3GNT4 (if available)

Paralogs for B3GNT4 Gene

(8) SIMAP similar genes for B3GNT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GNT4: view

Variants for B3GNT4 Gene

Sequence variations from dbSNP and Humsavar for B3GNT4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7136356 - 122,204,634(+) CCCAG(C/G)CTTCC intron-variant, reference, missense
rs1001178 - 122,206,498(-) GCTAG(A/G/T)CACTG reference, missense
rs35203505 - 122,206,511(+) CTCTC(C/T)GTCCC reference, missense
rs7304287 -- 122,204,948(+) tcgct(G/T)gaacc intron-variant
rs12822531 -- 122,204,418(+) GGGCC(A/G)CGGCG intron-variant

Variation tolerance for B3GNT4 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.32; 90.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for B3GNT4 Gene

Disorders for B3GNT4 Gene

Relevant External Links for B3GNT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for B3GNT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT4 Gene

Publications for B3GNT4 Gene

  1. Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4 67
  2. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for B3GNT4 Gene

Sources for B3GNT4 Gene