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Aliases for B3GNT3 Gene

Aliases for B3GNT3 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3 2 3 4
  • Transmembrane Protein 3 2 3 4
  • Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,3-N-Acetylglucosaminyltransferase 3 4
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 8 3 4
  • Core 1 Extending Beta-1,3-N-Acetylglucosaminyltransferase 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 8 3 4
  • Beta-1,3-N-Acetylglucosaminyltransferase BGnT-3 2 3
  • Putative Type II Membrane Protein 2 3
  • Beta-1,3-GalTase 8 3 4
  • Core1-Beta3GlcNAcT 3 4
  • Beta-1,3-Gn-T3 3 4
  • Beta-3-Gx-T8 3 4
  • Beta3GalT8 3 4
  • Beta3Gn-T3 3 4
  • B3GAL-T8 3 4
  • TMEM3 3 4
  • N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 3 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 3 4
  • Beta-1,3-Galactosyltransferase 8 4
  • EC 4
  • EC 4
  • Beta3Gal-T8 4
  • EC 2.4.1 63
  • B3GN-T3 3
  • B3GNT-3 3
  • HP10328 3
  • B3GALT8 4
  • TMEM3, 6
  • BGnT-3 4

External Ids for B3GNT3 Gene

Previous HGNC Symbols for B3GNT3 Gene

  • TMEM3

Previous GeneCards Identifiers for B3GNT3 Gene

  • GC19P018399
  • GC19P018298
  • GC19P017751
  • GC19P017905
  • GC19P017471

Summaries for B3GNT3 Gene

Entrez Gene Summary for B3GNT3 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT3 Gene

B3GNT3 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT3 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).

Gene Wiki entry for B3GNT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT3 Gene

Genomics for B3GNT3 Gene

Regulatory Elements for B3GNT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for B3GNT3 Gene

17,794,828 bp from pter
17,813,576 bp from pter
18,749 bases
Plus strand

Genomic View for B3GNT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT3 Gene

Proteins for B3GNT3 Gene

  • Protein details for B3GNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
    Protein Accession:
    Secondary Accessions:
    • B2RAS4
    • Q6NWU9
    • Q6NXU9
    • Q8WWR6
    • Q9C0J2

    Protein attributes for B3GNT3 Gene

    372 amino acids
    Molecular mass:
    42534 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC82374.1; Type=Frameshift; Positions=194, 196, 202, 204, 209, 215; Evidence={ECO:0000305};

neXtProt entry for B3GNT3 Gene

Proteomics data for B3GNT3 Gene at MOPED

Selected DME Specific Peptides for B3GNT3 Gene

Post-translational modifications for B3GNT3 Gene

  • Glycosylation at Asn64, Asn184, Asn202, Asn362, and Asn367
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for B3GNT3 Gene

Gene Families for B3GNT3 Gene

  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GNT3 Gene

Suggested Antigen Peptide Sequences for B3GNT3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2A9
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT3: view

Function for B3GNT3 Gene

Molecular function for B3GNT3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).

Enzyme Numbers (IUBMB) for B3GNT3 Gene

Gene Ontology (GO) - Molecular Function for B3GNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IDA 11042166
GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with B3GNT3: view

Phenotypes for B3GNT3 Gene

genes like me logo Genes that share phenotypes with B3GNT3: view

Animal Models for B3GNT3 Gene

MGI Knock Outs for B3GNT3:

Animal Model Products

miRNA for B3GNT3 Gene

miRTarBase miRNAs that target B3GNT3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GNT3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for B3GNT3 Gene

Localization for B3GNT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for B3GNT3 Gene COMPARTMENTS Subcellular localization image for B3GNT3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for B3GNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0005887 integral component of plasma membrane TAS 10072769
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with B3GNT3: view

Pathways for B3GNT3 Gene

genes like me logo Genes that share pathways with B3GNT3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9Y2A9-B3GN3_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GNT3 Gene

Gene Ontology (GO) - Biological Process for B3GNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with B3GNT3: view

Transcripts for B3GNT3 Gene

Unigene Clusters for B3GNT3 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GNT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: -
SP4: -

Relevant External Links for B3GNT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B3GNT3 Gene

mRNA expression in normal human tissues for B3GNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GNT3 Gene

This gene is overexpressed in Colon - Transverse (11.3), Stomach (8.6), Minor Salivary Gland (7.2), Esophagus - Mucosa (6.5), and Small Intestine - Terminal Ileum (4.6).

Protein differential expression in normal tissues for B3GNT3 Gene

This gene is overexpressed in Nasal epithelium (66.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for B3GNT3 Gene

SOURCE GeneReport for Unigene cluster for B3GNT3 Gene Hs.69009

mRNA Expression by UniProt/SwissProt for B3GNT3 Gene

Tissue specificity: Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.
genes like me logo Genes that share expressions with B3GNT3: view

In Situ Assay Products

No data available for Expression partners for B3GNT3 Gene

Orthologs for B3GNT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia B3GNT3 35
  • 80.37 (n)
  • 75.22 (a)
B3GNT3 36
  • 73 (a)
(Canis familiaris)
Mammalia B3GNT3 35
  • 79.66 (n)
  • 73.12 (a)
B3GNT3 36
  • 73 (a)
(Mus musculus)
Mammalia B3gnt3 35
  • 70.46 (n)
  • 68.06 (a)
B3gnt3 16
B3gnt3 36
  • 67 (a)
(Pan troglodytes)
Mammalia B3GNT3 35
  • 99.28 (n)
  • 99.46 (a)
B3GNT3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia B3gnt3 35
  • 70.74 (n)
  • 67.78 (a)
(Monodelphis domestica)
Mammalia B3GNT3 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia B3GNT3 36
  • 60 (a)
(Gallus gallus)
Aves -- 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145701 35
  • 56.7 (n)
  • 54.66 (a)
(Danio rerio)
Actinopterygii b3gnt3 35
  • 59.34 (n)
  • 57.7 (a)
b3gnt3 36
  • 46 (a)
si:ch211-126g16.10 36
  • 46 (a)
si:ch211-126g16.11 36
  • 46 (a)
zgc:86586 36
  • 44 (a)
Species with no ortholog for B3GNT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT3 Gene

Gene Tree for B3GNT3 (if available)
Gene Tree for B3GNT3 (if available)

Paralogs for B3GNT3 Gene

Selected SIMAP similar genes for B3GNT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with B3GNT3: view

Variants for B3GNT3 Gene

Sequence variations from dbSNP and Humsavar for B3GNT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14268 -- 17,812,986(+) CCCTG(C/T)AGCCC utr-variant-3-prime
rs36686 - 17,811,986(+) GCAAC(A/G)CCTGT missense, reference
rs36687 -- 17,810,097(+) ACAGC(A/G)CCCGG intron-variant
rs36688 -- 17,800,403(+) CAGGG(A/C)TGAGG intron-variant
rs36689 -- 17,799,830(+) AGAGC(A/G)ATCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B3GNT3 Gene

Variant ID Type Subtype PubMed ID
dgv50n68 CNV Loss 17160897
nsv911209 CNV Loss 21882294
dgv3764n71 CNV Loss 21882294
nsv911214 CNV Loss 21882294
dgv3765n71 CNV Loss 21882294
nsv911218 CNV Gain 21882294
nsv911219 CNV Loss 21882294
nsv911220 CNV Loss 21882294
nsv911221 CNV Loss 21882294
dgv3766n71 CNV Loss 21882294

Relevant External Links for B3GNT3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT3 Gene

Disorders for B3GNT3 Gene

Relevant External Links for B3GNT3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for B3GNT3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for B3GNT3 Gene

Publications for B3GNT3 Gene

  1. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 2 3 4
  2. Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4
  3. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. (PMID: 11439191) Yeh J.-C. … Fakuda M. (Cell 2001) 3 4
  4. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (PMID: 17827388) Cerhan J.R. … Slager S.L. (Blood 2007) 3 48
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 48

Products for B3GNT3 Gene

Sources for B3GNT3 Gene

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