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Aliases & Descriptions for B3GNT3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B3GAL-T8 2 | | B3GALT8 3 | | B3GN-T3 1, 2 | | B3GNT-3 1, 2 | | BGnT-3 3 | | Beta-3-Gx-T8 3 | | Beta3Gal-T8 3 | | Beta3Gn-T3 3 | | Core1-beta3GlcNAcT 3 | | EC 2.4.1.- 3 | | HP10328 1, 2 | | TMEM3 2, 3, 5 | | b3Gal-T8 3 | | beta3Gn-T3 1, 2 |
| | | Descriptions |
|---|
| Beta-1,3-GalTase 8 3 | | Beta-1,3-galactosyltransferase 8 3 | | Core 1 extending beta-1,3-N-acetylglucosaminyltransferase 3 | | UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8 3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8 3 | | beta-1,3-N-acetylglucosaminyltransferase bGnT-3 2 | | putative type II membrane protein 2 | | transmembrane protein 3 2 |
|
| | Search outside databases for aliases for B3GNT3 genePrevious GC identifers: GC19P018399 GC19P018298 GC19P017751 |
Summaries for B3GNT3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B3GNT3: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq] UniProtKB/Swiss-Prot: B3GN3_HUMAN, Q9Y2A9Function: Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharidesGene Wiki entry for B3GNT3 |
Genomic Location for B3GNT3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B3GNT3 gene 
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1B3GNT3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017766:
(about GC identifiers)
Start:
|
17,766,919 bp from pter |
End:
|
17,785,385 bp from pter |
Size:
|
18,467 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for B3GNT3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B3GN3_HUMAN, Q9Y2A9 (See
protein sequence)Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Size: 372 amino acids; 42515 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=CAC82374.1; Type=Frameshift; Positions=194, 196, 202, 204, 209, 215;
Secondary accessions: B2RAS4 Q6NWU9 Q6NXU9 Q8WWR6 Q9C0J2REFSEQ proteins: NP_055071.2
ENSEMBL proteins: ENSP00000321874
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B3GNT3: Assays for B3GNT3: | Protein
Domains/ Families for B3GNT3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y2A9
ProtoNet protein and cluster: Q9Y2A9 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GN3_HUMAN, Q9Y2A9Similarity: Belongs to the glycosyltransferase 31 family | Gene Function for B3GNT3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014256
Applied Biosystems Silencer® siRNAs for B3GNT3
Sigma-Aldrich siRNA for B3GNT3  Sigma-Aldrich shRNA for B3GNT3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014256                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014256                                  untagged cDNA clone in CMV expression vector: NM_014256 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014256
UniProtKB/Swiss-Prot: B3GN3_HUMAN, Q9Y2A9Function: Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharidesEnzyme Number (IUBMB): EC 2.4.1.- 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for B3gnt3):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008378 | galactosyltransferase activity |
IEA | -- | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | About this table | Pathways & Interactions for B3GNT3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: B3GN3_HUMAN, Q9Y2A9Pathway: Protein modification; protein glycosylation 5/15 Interacting proteins for B3GNT3 (ENSP000003218743) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006486 | protein amino acid glycosylation |
IEA | -- | About this table
|
Drugs & Compounds for B3GNT3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B3GNT3
|
Transcripts for B3GNT3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014256
Sigma-Aldrich siRNA for B3GNT3  Sigma-Aldrich shRNA for B3GNT3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014256 REFSEQ mRNAs for B3GNT3 gene: NM_014256.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014256               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014256                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014256                                  untagged cDNA clone in CMV expression vector: NM_014256  Additional cDNA sequence: BC066876.1 BC067423.1 10 DOTS entries: DT.95259878 DT.100786910 DT.91702134 DT.411543 DT.121431940 DT.100786905 DT.100786906 DT.121432096 DT.121432184 DT.121432183 24/131 AceView cDNA sequences (see all 131
):CR611299 AI738415 BM718996 BX483385 AW848963 BM837166 NM_014256 AB049585 CR614648 AI337293 BM682980 BM751524 AF293973 AB015630 AJ130847 R77875 BF109635 BM821698 AK075466 AI669036 AK075434 AI684023 BX359759 CD559581
highest scoring ESTs for B3GNT3:AB015630 AA131918 AA172052 AA367608 AA552420 AA552613 AA569131 AB049585 AF293973 AI023867 Unigene Clusters for B3GNT3: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Hs.69009 [show with all ESTs], Hs.657825 [show with all ESTs]Unigene Representative Sequences: NM_014256, BC066876
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | |
| SP1: | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for B3GNT3
1 Ensembl transcript including schematic representation: ENST00000318683
|
Expression for B3GNT3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B3GNT3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B3GNT3
1 / 2 / 3 3 probe-sets matching B3GNT3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.69009 Hs.657825
Expression variation in blood from EXPOLDB for B3GNT3 UniProtKB/Swiss-Prot: B3GN3_HUMAN, Q9Y2A9Tissue specificity: Expressed in colon, jejunum, stomach, esophagus, placenta and trachea |
Orthologs for B3GNT3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B3GNT3 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for B3GNT3
ENSEMBL Gene Tree for B3GNT3 | Paralogs for B3GNT3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B3GNT3 gene
- B3GNT72 B3GNT42
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for B3GNT3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B3GNT3 (up to first 250kb)
|
Disorders & Mutations for B3GNT3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605863
Human Gene Mutation Database: B3GNT3 Human Genome Epidemiology Navigator: B3GNT3 (1 document)
|
Medical News for B3GNT3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B3GNT3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for B3GNT3 gene (see all 16
):- Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. (PubMed id 11042166)2, 3, 4 Shiraishi N....Sasaki K. (2001)
- Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PubMed id 10072769)2, 3, 4 Yokoyama-Kobayashi M.... Kato S. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. (PubMed id 11439191)3, 4 Yeh J.-C.... Fakuda M. (2001)
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)3, 4 Amado M.... Clausen H. (1999)
- Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)4 Yu L.-R.... Veenstra T.D. (2007)
- Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (PubMed id 17827388)3 Cerhan J.R....Slager S.L. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3 Otsuki T....Isogai T. (2005)
|
Search for B3GNT3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B3GNT3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B3GNT3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GNT3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT3 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_536 |
|
| | | About This Section
| --
| Services for B3GNT3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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Incremental update: 13 Oct 2009
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