Aliases for B3GNT3 Gene
Aliases for B3GNT3 Gene
- UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3 2 3 4 5
- Transmembrane Protein 3 2 3 4
- Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,3-N-Acetylglucosaminyltransferase 3 4
- UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 8 3 4
- Core 1 Extending Beta-1,3-N-Acetylglucosaminyltransferase 3 4
- UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 8 3 4
- Beta-1,3-N-Acetylglucosaminyltransferase BGnT-3 2 3
- Putative Type II Membrane Protein 2 3
- Beta-1,3-GalTase 8 3 4
- Core1-Beta3GlcNAcT 3 4
- Beta-1,3-Gn-T3 3 4
- Beta-3-Gx-T8 3 4
- Beta3GalT8 3 4
- Beta3Gn-T3 3 4
- B3GAL-T8 3 4
External Ids for B3GNT3 Gene
- HGNC: 13528
- Entrez Gene: 10331
- Ensembl: ENSG00000179913
- OMIM: 605863
- UniProtKB: Q9Y2A9
Previous HGNC Symbols for B3GNT3 Gene
- TMEM3
Previous GeneCards Identifiers for B3GNT3 Gene
- GC19P018399
- GC19P018298
- GC19P017751
- GC19P017766
- GC19P017905
- GC19P017471
Summaries for B3GNT3 Gene
-
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]
GeneCards Summary for B3GNT3 Gene
B3GNT3 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and O-linked glycosylation. GO annotations related to this gene include galactosyltransferase activity and beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GNT6.
UniProtKB/Swiss-Prot for B3GNT3 Gene
-
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT3 Gene
Genomics for B3GNT3 Gene
Regulatory Elements for B3GNT3 Gene
Enhancers for B3GNT3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around B3GNT3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for B3GNT3 Gene
- Chromosome:
- 19
- Start:
- 17,794,828 bp from pter
- End:
- 17,813,576 bp from pter
- Size:
- 18,749 bases
- Orientation:
- Plus strand
Genomic View for B3GNT3 Gene
Genes around B3GNT3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Ensembl
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
B3GNT3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for B3GNT3 Gene
Proteins for B3GNT3 Gene
-
Protein details for B3GNT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2A9-B3GN3_HUMAN
- Recommended name:
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3
- Protein Accession:
- Q9Y2A9
- B2RAS4
- Q6NWU9
- Q6NXU9
- Q8WWR6
- Q9C0J2
Protein attributes for B3GNT3 Gene
- Size:
- 372 amino acids
- Molecular mass:
- 42534 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAC82374.1; Type=Frameshift; Positions=194, 196, 202, 204, 209, 215; Evidence={ECO:0000305};
Protein Expression for B3GNT3 Gene
Selected DME Specific Peptides for B3GNT3 Gene
- Q9Y2A9:
-
- PIDDVFLGMCL
- DILQWDF
Post-translational modifications for B3GNT3 Gene
Other Protein References for B3GNT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for B3GNT3
- Novus Biologicals Antibodies for B3GNT3
- Invitrogen Antibodies for B3GNT3
- antibodies-online Antibodies for B3GNT3: See all 23
- GeneTex B3GNT3 antibody for B3GNT3
Protein Products
-
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- Search Origene for MassSpec and Protein Over-expression Lysates for B3GNT3
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- antibodies-online Proteins for B3GNT3: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for B3GNT3
Domains & Families for B3GNT3 Gene
Gene Families for B3GNT3 Gene
Protein Domains for B3GNT3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for B3GNT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y2A9- Family:
-
- Belongs to the glycosyltransferase 31 family.
Function for B3GNT3 Gene
Molecular function for B3GNT3 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
- UniProtKB/Swiss-Prot Function:
- Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).
Enzyme Numbers (IUBMB) for B3GNT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008378 | galactosyltransferase activity | IEA | -- |
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | TAS | -- |
| GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for B3GNT3 Gene
- MGI mutant phenotypes for B3GNT3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for B3GNT3:
Animal Models for B3GNT3 Gene
- MGI Knock Outs for B3GNT3:
-
- B3gnt3 tm1Dgen
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for B3GNT3 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for B3GNT3
-
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miRNA for B3GNT3 Gene
- miRTarBase miRNAs that target B3GNT3
miRNA Products
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Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for B3GNT3
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for B3GNT3
-
ViGene Biosciences adenoviral particle packaged cDNA for B3GNT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for B3GNT3 gene
-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GNT3 Gene
Localization for B3GNT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for B3GNT3 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 4 |
| extracellular | 2 |
| endosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10072769 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for B3GNT3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Keratan sulfate/keratin metabolism | ||
| 4 | Metabolism of proteins | ||
| 5 | O-linked glycosylation | ||
Pathways by source for B3GNT3 Gene
1 BioSystems pathway for B3GNT3 Gene
9 Reactome pathways for B3GNT3 Gene
2 KEGG pathways for B3GNT3 Gene
UniProtKB/Swiss-Prot Q9Y2A9-B3GN3_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for B3GNT3 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| B3GNT2 | ||
| C6orf120 | ||
| CD19 | ||
| CSGALNACT2 | ||
| DSTYK |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0018146 | keratan sulfate biosynthetic process | TAS | -- |
| GO:0030311 | poly-N-acetyllactosamine biosynthetic process | IDA | 11042166 |
No data available for SIGNOR curated interactions for B3GNT3 Gene
Transcripts for B3GNT3 Gene
mRNA/cDNA for B3GNT3 Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (131) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for B3GNT3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for B3GNT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for B3GNT3
- GenScript: Design CRISPR guide RNA sequences for B3GNT3
miRNA Products
- Search ViGene Biosciences for B3GNT3
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for B3GNT3
- Browse OriGene Inhibitory RNA Products For B3GNT3
-
ViGene Biosciences ready-to-package AAV shRNAs for B3GNT3 gene
Clone Products
-
OriGene ORF clones in human for B3GNT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for B3GNT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for B3GNT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | - |
Expression for B3GNT3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for B3GNT3 Gene
This gene is overexpressed in Colon - Transverse (x11.3), Stomach (x8.6), Minor Salivary Gland (x7.2), Esophagus - Mucosa (x6.5), and Small Intestine - Terminal Ileum (x4.6).
This gene is overexpressed in Nasal epithelium (66.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for B3GNT3 Gene
NURSA nuclear receptor signaling pathways regulating expression of B3GNT3 Gene:
B3GNT3SOURCE GeneReport for Unigene cluster for B3GNT3 Gene:
Hs.69009mRNA Expression by UniProt/SwissProt for B3GNT3 Gene:
Q9Y2A9-B3GN3_HUMAN
Tissue specificity:
Expressed in colon, jejunum, stomach, esophagus, placenta and trachea.
Evidence on tissue expression from TISSUES for B3GNT3 Gene
- Stomach(4.3)
- Intestine(3.3)
Primer Products
-
OriGene qPCR primer pairs for B3GNT3
-
OriGene qPCR primer pairs and template standards for B3GNT3
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for B3GNT3 Gene
Orthologs for B3GNT3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | B3GNT3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | B3GNT3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | B3GNT3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | B3gnt3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | B3gnt3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | B3GNT3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | B3GNT3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100145701 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | b3gnt3 34 35 |
|
||
| si:ch211-126g16.10 35 |
|
ManyToMany | |||
| si:ch211-126g16.11 35 |
|
ManyToMany | |||
| zgc:86586 35 |
|
ManyToMany |
- Species where no ortholog for B3GNT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for B3GNT3 Gene
Paralogs for B3GNT3 Gene
(10) SIMAP similar genes for B3GNT3 Gene using alignment to 3 proteins:
Variants for B3GNT3 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000149153 | -- | 17,795,651(+) | GTTCC(A/G)GTGCT | intron-variant | |
| rs1000182016 | -- | 17,795,938(+) | GAGTG(C/G)ATAGG | intron-variant | |
| rs1000418679 | -- | 17,813,016(+) | TCTGC(C/T)AGTCA | utr-variant-3-prime | |
| rs1000477609 | -- | 17,794,248(+) | CATAT(C/G)TAGAA | upstream-variant-2KB | |
| rs1000867466 | -- | 17,807,104(+) | AGCAG(C/T)GGCCC | intron-variant |
Residual Variation Intolerance Score:
38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.76;
47.06% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for B3GNT3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT3 Gene
Disorders for B3GNT3 Gene
Relevant External Links for B3GNT3
No disorders were found for B3GNT3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GNT3 Gene
Publications for B3GNT3 Gene
- Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4 64
- Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PMID: 10072769) Yokoyama-Kobayashi M. … Kato S. (Gene 1999) 2 3 4 64
- L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
- Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (PMID: 17827388) Cerhan J.R. … Slager S.L. (Blood 2007) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for B3GNT3 Gene
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- antibodies-online Antibodies for B3GNT3: See all 23
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- GeneTex B3GNT3 antibody for B3GNT3
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- ViGene Biosciences adenoviral particle packaged cDNA for B3GNT3 gene
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- Horizon Cell Lines for B3GNT3
- Cyagen custom Knockout/knockin (KOKI) mouse models for B3GNT3
- VectorBuilder custom plasmid, inducible vectors for B3GNT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for B3GNT3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for B3GNT3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
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