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Aliases for B3GNT2 Gene

Aliases for B3GNT2 Gene

  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2 2 3 4
  • B3GNT1 3 4 6
  • UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 1 2 3
  • Beta-1,3-Gn-T1 3 4
  • Beta-1,3-Gn-T2 3 4
  • Beta3Gn-T1 3 4
  • Beta3Gn-T2 3 4
  • BGnT-2 3 4
  • B3GNT 3 6
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 7 4
  • N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 2 3
  • UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 7 4
  • Beta-1,3-N-Acetylglucosaminyltransferase BGnT-1 3
  • Beta-1,3-N-Acetylglucosaminyltransferase BGnT-2 3
  • Beta-1,3-N-Acetylglucosaminyltransferase 1 4
  • Beta-1,3-N-Acetylglucosaminyltransferase 2 4
  • Beta-1,3-Galactosyltransferase 7 4
  • Beta-1,3-GalTase 7 4
  • Beta-3-Gx-T7 4
  • EC 2.4.1.149 4
  • Beta3Gal-T7 4
  • Beta3GalT7 4
  • BETA3GNT 3
  • B3Gal-T7 4
  • B3GN-T2 3
  • B3GNT-2 3
  • B3GALT7 4
  • BGnT-1 4
  • BGNT2 3

External Ids for B3GNT2 Gene

Previous HGNC Symbols for B3GNT2 Gene

  • B3GNT1

Previous GeneCards Identifiers for B3GNT2 Gene

  • GC02P062276
  • GC02P062423

Summaries for B3GNT2 Gene

Entrez Gene Summary for B3GNT2 Gene

  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GNT2 Gene

B3GNT2 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GNT2 Gene

  • Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase.

Gene Wiki entry for B3GNT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GNT2 Gene

Genomics for B3GNT2 Gene

Regulatory Elements for B3GNT2 Gene

Genomic Location for B3GNT2 Gene

Start:
62,196,113 bp from pter
End:
62,224,731 bp from pter
Size:
28,619 bases
Orientation:
Plus strand

Genomic View for B3GNT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GNT2 Gene

Proteins for B3GNT2 Gene

  • Protein details for B3GNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY97-B3GN2_HUMAN
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
    Protein Accession:
    Q9NY97
    Secondary Accessions:
    • Q54AC1
    • Q9NQQ9
    • Q9NQR0
    • Q9NUT9

    Protein attributes for B3GNT2 Gene

    Size:
    397 amino acids
    Molecular mass:
    46022 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with B3GNT8; this interaction greatly increases B3GNT2 catalytic activity, independently of B3GNT8 enzymatic activity.
    SequenceCaution:
    • Sequence=BAA92031.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for B3GNT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for B3GNT2 Gene

Proteomics data for B3GNT2 Gene at MOPED

Post-translational modifications for B3GNT2 Gene

  • Ubiquitination at Lys50
  • Glycosylation at Asn79, Asn89, Asn127, Asn173, and Asn219
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GNT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for B3GNT2 ("Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2")

Protein Products

No data available for DME Specific Peptides for B3GNT2 Gene

Domains for B3GNT2 Gene

Gene Families for B3GNT2 Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GNT2 Gene

Suggested Antigen Peptide Sequences for B3GNT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY97

UniProtKB/Swiss-Prot:

B3GN2_HUMAN :
  • Q9NY97
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GNT2: view

Function for B3GNT2 Gene

Molecular function for B3GNT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase.

Enzyme Numbers (IUBMB) for B3GNT2 Gene

Gene Ontology (GO) - Molecular Function for B3GNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity IEA --
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IDA 11042166
genes like me logo Genes that share ontologies with B3GNT2: view
genes like me logo Genes that share phenotypes with B3GNT2: view

Animal Model Products

miRNA for B3GNT2 Gene

miRTarBase miRNAs that target B3GNT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GNT2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for B3GNT2 Gene

Localization for B3GNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GNT2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for B3GNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with B3GNT2: view

No data available for Subcellular locations from COMPARTMENTS for B3GNT2 Gene

Pathways for B3GNT2 Gene

genes like me logo Genes that share pathways with B3GNT2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NY97-B3GN2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for B3GNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0007411 axon guidance IEA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with B3GNT2: view

Compounds for B3GNT2 Gene

(3) HMDB Compounds for B3GNT2 Gene

Compound Synonyms Cas Number PubMed IDs
Lacto-N-triaose
  • Agalacto-N-neotetraose
75645-27-1
Manganese
  • manganese
7439-96-5
Poly-N-acetyllactosamine
  • Poly(N-acetyllactosamine)
82441-98-3
genes like me logo Genes that share compounds with B3GNT2: view

Transcripts for B3GNT2 Gene

mRNA/cDNA for B3GNT2 Gene

Unigene Clusters for B3GNT2 Gene

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GNT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GNT2 Gene

No ASD Table

Relevant External Links for B3GNT2 Gene

GeneLoc Exon Structure for
B3GNT2
ECgene alternative splicing isoforms for
B3GNT2

Expression for B3GNT2 Gene

mRNA expression in normal human tissues for B3GNT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for B3GNT2 Gene

This gene is overexpressed in Serum (47.4) and Plasma (15.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for B3GNT2 Gene

SOURCE GeneReport for Unigene cluster for B3GNT2 Gene Hs.173203

mRNA Expression by UniProt/SwissProt for B3GNT2 Gene

Q9NY97-B3GN2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with B3GNT2: view

Expression partners for B3GNT2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for B3GNT2 Gene

Orthologs for B3GNT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for B3GNT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GNT2 35
  • 87.91 (n)
  • 88.66 (a)
-- 36
  • 85 (a)
OneToMany
B3GNT2 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia B3GNT2 35
  • 89.25 (n)
  • 91.94 (a)
B3GNT2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3gnt2 35
  • 84.97 (n)
  • 87.41 (a)
B3gnt2 16
B3gnt2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B3GNT2 35
  • 99.66 (n)
  • 100 (a)
B3GNT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3gnt2 35
  • 84.47 (n)
  • 87.91 (a)
oppossum
(Monodelphis domestica)
Mammalia B3GNT2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GNT2 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GNT2 35
  • 74.14 (n)
  • 74.56 (a)
B3GNT2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B3GNT2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b3gnt2 35
  • 67.34 (n)
  • 68.26 (a)
Str.7170 35
zebrafish
(Danio rerio)
Actinopterygii b3gnt2b 35
  • 60.82 (n)
  • 57.99 (a)
wufa55h04 35
B3GNT2 (2 of 4) 36
  • 40 (a)
OneToMany
B3GNT2 (3 of 4) 36
  • 35 (a)
OneToMany
b3gnt2a 36
  • 53 (a)
OneToMany
b3gnt2b 36
  • 57 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.163 36
  • 33 (a)
OneToMany
Species with no ortholog for B3GNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GNT2 Gene

ENSEMBL:
Gene Tree for B3GNT2 (if available)
TreeFam:
Gene Tree for B3GNT2 (if available)

Paralogs for B3GNT2 Gene

Selected SIMAP similar genes for B3GNT2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for B3GNT2 Gene

genes like me logo Genes that share paralogs with B3GNT2: view

Variants for B3GNT2 Gene

Sequence variations from dbSNP and Humsavar for B3GNT2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1008724 -- 62,202,976(+) TCTGA(C/G)AGGAG intron-variant
rs1008725 -- 62,203,073(+) CAGCA(A/G)TCAAC intron-variant
rs1136151 -- 62,223,608(+) TTTTA(C/T)GGATG utr-variant-3-prime
rs1562745 -- 62,202,898(+) GGCAC(A/G)AGGCC intron-variant
rs1562746 -- 62,202,978(+) TGAGA(A/G)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B3GNT2 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
nsv874231 CNV Gain 21882294

Relevant External Links for B3GNT2 Gene

HapMap Linkage Disequilibrium report
B3GNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GNT2 Gene

Disorders for B3GNT2 Gene

Relevant External Links for B3GNT2

Genetic Association Database (GAD)
B3GNT2

No disorders were found for B3GNT2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for B3GNT2 Gene

Publications for B3GNT2 Gene

  1. A beta-1,3-N-acetylglucosaminyltransferase with poly-N- acetyllactosamine synthase activity is structurally related to beta- 1,3-galactosyltransferases. (PMID: 9892646) Zhou D. … Hennet T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Identification and characterization of three novel beta 1,3-N- acetylglucosaminyltransferases structurally related to the beta 1,3- galactosyltransferase family. (PMID: 11042166) Shiraishi N. … Sasaki K. (J. Biol. Chem. 2001) 2 3 4 23
  3. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PMID: 10580128) Amado M. … Clausen H. (Biochim. Biophys. Acta 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4

Products for B3GNT2 Gene

Sources for B3GNT2 Gene

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