B3GNT2 Gene
protein-coding GIFtS: 54
GC02P062276
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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (Previous name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: B3GNT1)
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Aliases & Descriptions for B3GNT2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
|---|
| B3GALT7 3 | | B3GN-T1 1, 2 | | B3GN-T2 1, 2 | | B3GNT 2 | | B3GNT-2 1, 2 | | B3GNT1 2, 3 | | BETA3GNT 1, 2 | | BGnT-1 3 | | Beta-3-Gx-T7 3 | | Beta3Gal-T7 3 | | Beta3Gn-T1 3 | | EC 2.4.1.- 3 | | b3Gal-T7 3 | | beta3gal-T5 2 |
| | | Descriptions |
|---|
| Beta-1,3-GalTase 7 3 | | Beta-1,3-galactosyltransferase 7 3 | | UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7 3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 1, 2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7 3 | | beta-1,3-N-acetylglucosaminyltransferase bGnT-1 2 | | beta-1,3-N-acetylglucosaminyltransferase bGnT-2 2 |
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| | Search outside databases for aliases for B3GNT2 gene |
Summaries for B3GNT2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B3GNT2: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. [provided by RefSeq] UniProtKB/Swiss-Prot: B3GN2_HUMAN, Q9NY97Function: Catalyzes the initiation and elongation of poly-N-acetyllactosamine chainsGene Wiki entry for B3GNT2 |
Genomic Location for B3GNT2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B3GNT2 gene 
Entrez Gene cytogenetic band: 2p15 Ensembl cytogenetic band: 2p15 HGNC cytogenetic band: 2p15B3GNT2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P062276:
(about GC identifiers)
Start:
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62,276,766 bp from pter |
End:
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62,305,370 bp from pter |
Size:
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28,605 bases |
Orientation:
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plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for B3GNT2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B3GN2_HUMAN, Q9NY97 (See
protein sequence)Recommended Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Size: 397 amino acids; 46022 Da
Cofactor: Manganese
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Caution: Was indicated as B3Gal-T6 in submitted DNA entries
Secondary accessions: Q9NQQ9 Q9NQR0 Q9NUT9Alternative splicing: 2 isoforms: Q9NY97-1 Q9NY97-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006568.2
ENSEMBL proteins: ENSP00000384692 ENSP00000305595 ENSP00000344143
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B3GNT2: Assays for B3GNT2: | Protein
Domains/ Families for B3GNT2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NY97
ProtoNet protein and cluster: Q9NY97 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GN2_HUMAN, Q9NY97Similarity: Belongs to the glycosyltransferase 31 family | Gene Function for B3GNT2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033252
Applied Biosystems Silencer® siRNAs for B3GNT2
Sigma-Aldrich siRNA for B3GNT2  Sigma-Aldrich shRNA for B3GNT2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006577                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006577                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006577 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006577
UniProtKB/Swiss-Prot: B3GN2_HUMAN, Q9NY97Function: Catalyzes the initiation and elongation of poly-N-acetyllactosamine chainsEnzyme Number (IUBMB): EC 2.4.1.- 6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for B3gnt2):
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008378 | galactosyltransferase activity |
IEA | -- | | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
NAS | -- | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | | GO:0030145 | manganese ion binding |
IEA | -- | About this table | Pathways & Interactions for B3GNT2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for B3GNT2 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: B3GN2_HUMAN, Q9NY97Pathway: Protein modification; protein glycosylation 5/16 Interacting proteins for B3GNT2 (ENSP000003055953) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006486 | protein amino acid glycosylation |
IEA | -- | | GO:0008150 | biological_process |
ND | -- | About this table
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Drugs & Compounds for B3GNT2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for B3GNT2
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Transcripts for B3GNT2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_033252
Sigma-Aldrich siRNA for B3GNT2  Sigma-Aldrich shRNA for B3GNT2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006577 REFSEQ mRNAs for B3GNT2 gene: NM_006577.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006577               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006577                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006577                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006577  Additional cDNA sequence: AB049584.1 AF092051.2 AF288208.1 AF288209.1 AJ006077.1 AK002009.1 BC030579.2 BC047933.1 XM_001718549.1 9 DOTS entries: DT.213887 DT.100748568 DT.100023248 DT.95164130 DT.121021177 DT.100716809 DT.100773165 DT.121021201 DT.91996120 24/124 AceView cDNA sequences (see all 124
):D87736 AA936769 BM557603 BQ101164 AA310578 BU753670 CK823150 AW136376 BX106672 AW613027 AA381830 BQ029038 AA835126 AI862049 BQ000660 AA377081 AA873030 AA381631 BG319463 BU620612 AI638560 CD367444 AI569147 BC047933
highest scoring ESTs for B3GNT2:AA310578 AA377081 AA449869 AA773646 AA873030 AA936769 AB049584 AF092051 AF288208 AF288209 Unigene Cluster for B3GNT2: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Hs.173203 [show with all ESTs]Unigene Representative Sequence: BC047933
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000405767
ENST00000301998
ENST00000340715
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Expression for B3GNT2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B3GNT2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B3GNT2
1 / 2 / 3 4 probe-sets matching B3GNT2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATATTTTAAA
SOURCE GeneReport for Unigene cluster: Hs.173203
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Orthologs for B3GNT2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for B3GNT2 gene from 5/8 species (see all 8
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About this table Species with no ortholog for B3GNT2
ENSEMBL Gene Tree for B3GNT2 | Paralogs for B3GNT2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B3GNT2 gene
- B3GNT82
Pseudogenes
- 1 related pseudogene
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SNPs/Variants for B3GNT2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for B3GNT2 (up to first 250kb)
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Disorders & Mutations for B3GNT2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 605581
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Medical News for B3GNT2(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for B3GNT2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for B3GNT2 gene (see all 16
):- A beta-1,3-N-acetylglucosaminyltransferase with poly-N- acetyllactosamine synthase activity is structurally related to beta- 1,3-galactosyltransferases. (PubMed id 9892646)1, 2, 3, 4 Zhou D.... Hennet T. (1999)
- Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. (PubMed id 11042166)1, 2, 3 Shiraishi N....Sasaki K. (2001)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)3, 4 Hillman R.T.... Brenner S.E. (2004)
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)3, 4 Amado M.... Clausen H. (1999)
- Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. (PubMed id 18826941)3 Seko A. and Yamashita K. (2008)
- Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans. (PubMed id 14686931)3 Mare L. and Trinchera M. (2004)
- Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase. (PubMed id 15560372)3 Zheng H.... Mao Y. (2004)
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Search for B3GNT2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing B3GNT2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B3GNT2
(According to HUGE)
About This Section
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Specialized Databases showing B3GNT2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT1 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_434 |
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| Services for B3GNT2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for B3GNT2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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