Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B3GAT2 Gene

protein-coding   GIFtS: 57
GCID: GC06M071566

beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase...

 Explore 5 diseases affiliated with
B3GAT2 via our new
 Human Malady Compendium 
Biological research products
for B3GAT2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Beta-1,3-Glucuronyltransferase 2 (Glucuronosyltransferase S)1 2     Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 22
GLCATS2 3 5     GlcAT-D3
GlcAT-S1 3     UDP-Glucuronyltransferase S2
Glucuronosyltransferase S2 3     Uridine Diphosphate Glucuronic Acid:Acceptor Glucuronosyltransferase2
UDP-Glucuronosyltransferase S2 3     GlcAT-D3
EC 2.4.1.1353 8     Beta-1,3-Glucuronyltransferase 23
KIAA19633 5     

External Ids:    HGNC: 9221   Entrez Gene: 1351522   Ensembl: ENSG000001123097   OMIM: 6074975   UniProtKB: Q9NPZ53   

Export aliases for B3GAT2 gene to outside databases

Previous GC identifers: GC00U990665 GC06M071533 GC06M071562 GC06M071623 GC06M068769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for B3GAT2:
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the
transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids
containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the
human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and
adhesion in the nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: B3GA2_HUMAN, Q9NPZ5
Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By
similarity)

Gene Wiki entry for B3GAT2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B3GAT2 gene promoter:
         AREB6   N-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for B3GAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13   Ensembl cytogenetic band:  6q13   HGNC cytogenetic band: 6q12

B3GAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GAT2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M071566:  view genomic region     (about GC identifiers)

Start:
71,566,382 bp from pter      End:
71,666,788 bp from pter
Size:
100,407 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B3GA2_HUMAN, Q9NPZ5 (See protein sequence)
Recommended Name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2  
Size: 323 amino acids; 36919 Da
Cofactor: Manganese
Subunit: Homodimer (Potential)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAB70889.1; Type=Erroneous initiation; Sequence=BAB85549.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for B3GAT2:
2D0J (3D)    
Secondary accessions: Q5JS09 Q8TF38 Q96NK4

Explore the universe of human proteins at neXtProt for B3GAT2: NX_Q9NPZ5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPZ5

  • 4/5 DME Specific Peptides for B3GAT2 (Q9NPZ5) (see all 5)
     VWHTRTEK  VWPVGLVGG  RPFAIDMAGFAV  FADDDNTYSLELF 

    B3GAT2 Protein expression data from MOPED and PaxDb:    About this image 
    B3GAT2 Protein Expression
    REFSEQ proteins: NP_542780.1  
    ENSEMBL proteins: 
     ENSP00000230053  
    Reactome Protein details: Q9NPZ5
    Human Recombinant Protein Products for B3GAT2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for B3GAT2 
    GenScript Custom Purified and Recombinant Proteins Services for B3GAT2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--

    B3GAT2 for ontologies           About GeneDecksing



    B3GAT2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for B3GAT2 
    GenScript Custom Superior Antibodies Services for B3GAT2
    Novus Biologicals B3GAT2 Antibodies
    Abcam antibodies for B3GAT2 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for B3GAT2

    Assay Products for B3GAT2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for B3GAT2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    B3GAT2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005027 Glyco_trans_43

    Graphical View of Domain Structure for InterPro Entry Q9NPZ5

    ProtoNet protein and cluster: Q9NPZ5

    1 Blocks protein family: IPB005027 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GA2_HUMAN, Q9NPZ5
    Similarity: Belongs to the glycosyltransferase 43 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3GA2_HUMAN, Q9NPZ5
    Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By
    similarity)
    Catalytic activity: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP +
    3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein

         Enzyme Number (IUBMB): EC 2.4.1.1351 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015018galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISS--
    GO:0046872metal ion binding IEA--
         
    B3GAT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for B3GAT2:
     Increased viability after born 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for B3GAT2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: B3GAT2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat B3GAT2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate B3GAT2
    SwitchGear 3'UTR luciferase reporter plasmidB3GAT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GAT2 (see all 6)
    OriGene shRNA RFP: B3GAT2
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GAT2
    Sirion Biotech Custom design and validation of potent shRNA sequences against B3GAT2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for B3GAT2
    Sirion Biotech Customized adenovirus for overexpression of B3GAT2 
    Sirion Biotech Customized adenovirus for potent knockdown of B3GAT2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GAT2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: B3GAT2 (NM_080742)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GAT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for B3GAT2
    Search LifeMap BioReagents cell lines for B3GAT2
    Sirion Biotech Customized stable knockdown cell line services for B3GAT2 
    Sirion Biotech Customized inducible knockdown cell line services for B3GAT2
    Sirion Biotech Customized stable overexpressing cell line services for B3GAT2
    Sirion Biotech Customized inducible overexpressing cell line services for B3GAT2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GAT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/15 pathways (see all 15)
    MPS VI - Maroteaux-Lamy syndrome1.00
    MPS IIIA - Sanfilippo syndrome A1.00
    MPS IIIC - Sanfilippo syndrome C1.00
    MPS IIID - Sanfilippo syndrome D1.00
    MPS I - Hurler syndrome1.00
    MPS IX - Natowicz syndrome1.00
    Mucopolysaccharidoses1.00
    MPS II - Hunter syndrome1.00
    2dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis1.00
    chondroitin sulfate biosynthesis0.64
    Glycosaminoglycan biosynthesis - chondroitin sulfate0.73
    glycoaminoglycan-protein linkage region biosynthesis0.38
    3A tetrasaccharide linker sequence is required for GAG synthesis
    A tetrasaccharide linker sequence is required for GAG synthesis1.00
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    4Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    5heparan sulfate biosynthesis
    heparan sulfate biosynthesis1.00
    Glycosaminoglycan biosynthesis - heparan sulfate0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for B3GAT2 
        glycoaminoglycan-protein linkage region biosynthesis
    heparan sulfate biosynthesis
    dermatan sulfate biosynthesis
    chondroitin sulfate biosynthesis

    5/19        Reactome Pathways for B3GAT2 (see all 19)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    3         Kegg Pathways  (Kegg details for B3GAT2):
        Glycosaminoglycan biosynthesis - chondroitin sulfate
    Glycosaminoglycan biosynthesis - heparan sulfate
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GA2_HUMAN, Q9NPZ5
    Pathway: Protein modification; protein glycosylation


    B3GAT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for B3GAT2 (ENSP000002300534) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT6ENSP000003684964STRING: ENSP00000368496
    CSGALNACT1ENSP000003108914STRING: ENSP00000310891
    CSGALNACT2ENSP000003635904STRING: ENSP00000363590
    EXTL2ENSP000003591314STRING: ENSP00000359131
    EXTL3ENSP000002205624STRING: ENSP00000220562
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006486protein glycosylation IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    B3GAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    B3GAT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for B3GAT2

    3 HMDB Compounds for B3GAT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    2 Novoseek chemical compound relationships for B3GAT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paragloboside 90.8 1 15470230 (1)
    glycolipid 68.2 1 15470230 (1)

    Search CenterWatch for drugs/clinical trials and news about B3GAT2 / B3GA2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for B3GAT2 gene: 
    NM_080742.2  

    Unigene Cluster for B3GAT2:

    Beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
    Hs.713609  [show with all ESTs]
    Unigene Representative Sequence: AB075843
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000230053(uc003pfv.3 uc003pfw.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: B3GAT2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat B3GAT2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate B3GAT2
    SwitchGear 3'UTR luciferase reporter plasmidB3GAT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GAT2 (see all 6)
    OriGene shRNA RFP: B3GAT2
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GAT2
    Sirion Biotech Custom design and validation of potent shRNA sequences against B3GAT2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GAT2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: B3GAT2 (NM_080742)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GAT2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GAT2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B3GAT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GAT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GAT2

    Additional cDNA sequence: 

    AB075843.1 AK290018.1 AY070019.1 BC113995.1 

    10 DOTS entries:

    DT.308112  DT.454075  DT.454074  DT.95310418  DT.100784972  DT.91971398  DT.100703908  DT.121383613 
    DT.92407740  DT.95310431 

    24/49 AceView cDNA sequences (see all 49):

    BG149793 AB075843 F11751 NM_080742 AI138778 BF477827 BM693450 BM698655 
    AY070019 BM670746 AW590323 BM674929 AU253732 F05538 CB164059 R18896 
    R21032 BE089137 BM717735 BE550679 AI702728 D25748 AK055248 AI214308 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for B3GAT2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for B3GAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    B3GAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTATAAGC
    B3GAT2 Expression
    About this image
    See B3GAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for B3GAT2

    SOURCE GeneReport for Unigene cluster: Hs.713609

    UniProtKB/Swiss-Prot: B3GA2_HUMAN, Q9NPZ5
    Tissue specificity: Expressed in the trachea, retina, spinal cord, hippocampus and other brain regions, and, at lower
    levels, in testis and ovary

        SABiosciences Custom PCR Arrays for B3GAT2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GAT2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B3GAT2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GAT2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GAT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for B3GAT2 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B3gat21 , 5 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase more1, 5 88.54(n)1
    90.71(a)1
      1 (9.75 cM)5
    2806451  NM_172124.21  NP_742122.21 
     237617535 
    chicken
    (Gallus gallus)
    Aves B3GAT21 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase more 85.24(n)
    92.09(a)
      428638  NM_001031527.1  NP_001026698.1 
    lizard
    (Anolis carolinensis)
    Reptilia B3GAT26
    --
    76(a)
    1 ↔ 1
    1(167810951-167848701)
    zebrafish
    (Danio rerio)
    Actinopterygii AF506207.12   -- 73.84(n)   192334  AF506207.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta GlcAT-I6
    GlcAT-S6
    (see all 3)
    GlcAT-S
    (see all 3)
    42(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(4025250-4026866)
    2L(9616469-9623109)
    worm
    (Caenorhabditis elegans)
    Secernentea glct-16
    sqv-86
    (see all 7)
    Probable glucuronosyltransferase sqv-8
    (see all 7)
    33(a)
    32(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    I(12337959-12339230)
    II(9647879-9649165)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IRX9-L1 nucleotide-diphospho-sugar transferase domain-containing more 45.68(n)
    37.04(a)
      839652  NM_102525.2  NP_564290.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g02053001 hypothetical protein 48.82(n)
    36.73(a)
      4348270  NM_001070845.1  NP_001064310.1 


    ENSEMBL Gene Tree for B3GAT2 (if available)
    TreeFam Gene Tree for B3GAT2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for B3GAT2 gene
    B3GAT12  B3GAT32  
    3 SIMAP similar genes for B3GAT2 using alignment to 2 protein entries:     B3GA2_HUMAN (see all proteins):
    DKFZp547E046    B3GAT3    B3GAT1

    B3GAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1558 NCBI SNPs in B3GAT2 are shown (see all 1558    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819868651,2
    --71572266(+) GGTATG/TTGGGG 1 -- int10--------
    rs1868764171,2
    --71572294(+) GATATA/CAGGCC 1 -- int10--------
    rs1487060561,2
    --71572415(+) CATCTA/GTAATC 1 -- int10--------
    rs1914669751,2
    --71572492(+) GCATAA/GTGAGA 1 -- int10--------
    rs1380982191,2
    C--71572513(+) CAAAA-/AATAATAC 1 -- int10--------
    rs1422665471,2
    --71572566(+) TCCCAA/GCTACT 1 -- int10--------
    rs1179905181,2
    F--71572771(+) GCCATC/TTCAGC 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1512858651,2
    --71572810(+) CCCTGC/GATCTC 1 -- int10--------
    rs20384771,2
    C,F,A,H--71573109(+) ATAACG/ATGGTA 1 -- int129Minor allele frequency- A:0.34NS EA NA CSA WA 2909
    rs1426829061,2
    --71573372(+) CTCAA-/TGTT  
            
    TGATG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for B3GAT2 (71566382 - 71666788 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for B3GAT2
         1 CNV: 0086

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for B3GAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    B3GAT2 for disorders           About GeneDecksing

    OMIM gene information: 607497    OMIM disorders: --

    5 diseases for B3GAT2:    About MalaCards
    drug-induced hepatitis    gilbert syndrome    autoimmune hepatitis    hepatitis
    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: B3GAT2 (4 documents)

    Export disorders for B3GAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for B3GAT2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with B3GAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope. (PubMed id 16897771)1, 2, 9 Shiba T....Kato R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Cloning, characterization, and chromosome mapping of the human GlcAT- S gene. (PubMed id 12522689)1, 2 Marcos I.... Antinolo G. (2002)
    5. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    6. Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate. (PubMed id 15470230)1, 9 Kakuda S....Kawasaki T. (2005)
    7. Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli. (PubMed id 15039073)1, 9 Kakuda S....Kawasaki T. (2004)
    8. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associa ted with disease risk and cortical surface area. (PubMed id 20950796)1 KAohler A.K....Andreassen O.A. (2011)
    9. Genome-wide association study identifies genetic vari ants influencing F-cell levels in sickle-cell patients. (PubMed id 21326311)1 Bhatnagar P....Keefer J.R. (2011)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 135152 HGNC: 922 AceView: B3GAT2 Ensembl:ENSG00000112309 euGenes: HUgn135152
    ECgene: B3GAT2 Kegg: 135152 H-InvDB: B3GAT2

    (According to HUGE)
    About This Section
    HUGE: KIAA1963

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for B3GAT2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for B3GAT2 gene:
    Search GeneIP for patents involving B3GAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for B3GAT2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GAT2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GAT2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for B3GAT2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GAT2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GAT2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for B3GAT2   OriGene Custom Protein Services for B3GAT2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat B3GAT2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GAT2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GAT2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GAT2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GAT2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GAT2
     GenScript Custom Purified and Recombinant Proteins Services for B3GAT2 GenScript cDNA clones with any tag delivered in your preferred vector for B3GAT2
     GenScript Custom Assay Services for B3GAT2 GenScript Custom Superior Antibodies Services for B3GAT2
     GenScript Custom overexpressing Cell Line Services for B3GAT2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in B3GAT2 promoter
     Search Chromatin IP Primers for B3GAT2
     RT2 qPCR Primer Assay in human, mouse, rat B3GAT2
     Search GNC Networks for B3GAT2
     SABiosciences Custom PCR Arrays for B3GAT2
     Search Tocris compounds for B3GAT2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     B3GAT2 antibodies
     Antibodies for B3GAT2
     See all of Abcam's Antibodies, Kits and Proteins for B3GAT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for B3GAT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GAT2
     SwitchGear 3'UTR luciferase reporter plasmids for B3GAT2
     SwitchGear Promoter luciferase reporter plasmids for B3GAT2
     ThermoFisher Antibodies for B3GAT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GAT2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for B3GAT2
    Sirion Biotech Customized:
     stable knockdown cell line services for B3GAT2
     inducible knockdown cell line services for B3GAT2
     design and validation of potent shRNA sequences against B3GAT2
     adenovirus for potent knockdown of B3GAT2
     adenovirus for overexpression of B3GAT2
     stable overexpressing cell line services for B3GAT2
     inducible overexpressing cell line services for B3GAT2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      B3GAT2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4