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Aliases for B3GALTL Gene

Aliases for B3GALTL Gene

  • Beta 1,3-Galactosyltransferase-Like 2 3
  • B3GTL 3 4 6
  • Beta-3-Glycosyltransferase-Like 3 4
  • Beta3Glc-T 3 4
  • B3GLCT 3 6
  • UDP-GAL:Beta-GlcNAc Beta-1,3-Galactosyltransferase-Like 3
  • Beta 3-Glycosyltransferase-Like 3
  • Beta-1,3-Glucosyltransferase 3
  • EC 2.4.1.- 4
  • B3Glc-T 3
  • Gal-T 3

External Ids for B3GALTL Gene

Previous GeneCards Identifiers for B3GALTL Gene

  • GC13P030674
  • GC13P031774
  • GC13P012600

Summaries for B3GALTL Gene

Entrez Gene Summary for B3GALTL Gene

  • The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009]

GeneCards Summary for B3GALTL Gene

B3GALTL (Beta 1,3-Galactosyltransferase-Like) is a Protein Coding gene. Diseases associated with B3GALTL include peters anomaly. Among its related pathways are Other types of O-glycan biosynthesis. GO annotations related to this gene include transferase activity, transferring glycosyl groups.

UniProtKB/Swiss-Prot for B3GALTL Gene

  • O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.

Gene Wiki entry for B3GALTL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GALTL Gene

Genomics for B3GALTL Gene

Regulatory Elements for B3GALTL Gene

Genomic Location for B3GALTL Gene

31,199,936 bp from pter
31,332,276 bp from pter
132,341 bases
Plus strand

Genomic View for B3GALTL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GALTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GALTL Gene

Proteins for B3GALTL Gene

  • Protein details for B3GALTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K5F8
    • Q5W0H2
    • Q6NUI3

    Protein attributes for B3GALTL Gene

    498 amino acids
    Molecular mass:
    56564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GALTL Gene

Proteomics data for B3GALTL Gene at MOPED

Post-translational modifications for B3GALTL Gene

  • Glycosylation at Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GALTL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for B3GALTL Gene

Domains for B3GALTL Gene

Gene Families for B3GALTL Gene

  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GALTL Gene

Suggested Antigen Peptide Sequences for B3GALTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6Y288
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GALTL: view

Function for B3GALTL Gene

Molecular function for B3GALTL Gene

UniProtKB/Swiss-Prot Function:
O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.

Enzyme Numbers (IUBMB) for B3GALTL Gene

Gene Ontology (GO) - Molecular Function for B3GALTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with B3GALTL: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for B3GALTL Gene

Localization for B3GALTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GALTL Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for B3GALTL Gene COMPARTMENTS Subcellular localization image for B3GALTL gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for B3GALTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GALTL: view

Pathways for B3GALTL Gene

genes like me logo Genes that share pathways with B3GALTL: view

Pathways by source for B3GALTL Gene

1 KEGG pathway for B3GALTL Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q6Y288-B3GLT_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GALTL Gene

Gene Ontology (GO) - Biological Process for B3GALTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006004 fucose metabolic process IEA --
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0036066 protein O-linked fucosylation TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with B3GALTL: view

Compounds for B3GALTL Gene

(4) Novoseek inferred chemical compound relationships for B3GALTL Gene

Compound -log(P) Hits PubMed IDs
nocodazole 56.6 2
monensin 55.7 6
n-acetylglucosamine 48.2 2
polysaccharide 22.1 1
genes like me logo Genes that share compounds with B3GALTL: view

Transcripts for B3GALTL Gene

Unigene Clusters for B3GALTL Gene

Beta 1,3-galactosyltransferase-like:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GALTL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GALTL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP1: - - - - - - -
SP2: -
SP3: - - - -

Relevant External Links for B3GALTL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B3GALTL Gene

mRNA expression in normal human tissues for B3GALTL Gene

Protein differential expression in normal tissues for B3GALTL Gene

This gene is overexpressed in Uterus (12.3) and Ovary (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for B3GALTL Gene

SOURCE GeneReport for Unigene cluster for B3GALTL Gene Hs.13205

mRNA Expression by UniProt/SwissProt for B3GALTL Gene

Tissue specificity: Widely expressed, with highest levels in testis and uterus.
genes like me logo Genes that share expressions with B3GALTL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for B3GALTL Gene

Orthologs for B3GALTL Gene

This gene was present in the common ancestor of animals.

Orthologs for B3GALTL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia B3GALTL 35
  • 90.54 (n)
  • 92.9 (a)
  • 80 (a)
(Mus musculus)
Mammalia B3galtl 35
  • 82.34 (n)
  • 84.87 (a)
B3galtl 16
B3galtl 36
  • 85 (a)
(Pan troglodytes)
Mammalia B3GALTL 35
  • 99.4 (n)
  • 99.2 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia B3galtl 35
  • 83.12 (n)
  • 85.04 (a)
(Bos Taurus)
Mammalia B3GALTL 36
  • 88 (a)
(Monodelphis domestica)
Mammalia B3GALTL 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia B3GALTL 36
  • 73 (a)
(Gallus gallus)
Aves B3GALTL 35
  • 74.7 (n)
  • 76.1 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia B3GALTL 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia b3galtl 35
  • 66.11 (n)
  • 65.83 (a)
(Danio rerio)
Actinopterygii b3galtlb 35
  • 62.08 (n)
  • 60.72 (a)
Dr.20640 35
b3galtla 36
  • 68 (a)
b3galtlb 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2664 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009562 35
  • 49.92 (n)
  • 46.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9109 35
  • 48.08 (n)
  • 40.05 (a)
CG9109 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea ZC250.2 35
  • 48.24 (n)
  • 37.47 (a)
ZC250.2 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for B3GALTL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B3GALTL Gene

Gene Tree for B3GALTL (if available)
Gene Tree for B3GALTL (if available)

Paralogs for B3GALTL Gene

No data available for Paralogs for B3GALTL Gene

Variants for B3GALTL Gene

Sequence variations from dbSNP and Humsavar for B3GALTL Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs4057 -- 31,332,154(-) ACAAC(A/G)AGAGG utr-variant-3-prime
rs13080 -- 31,332,004(-) TAGTT(G/T)CAAGA utr-variant-3-prime
rs728930 -- 31,274,686(-) CATTA(C/T)GCACA intron-variant
rs755870 -- 31,231,679(-) ACACT(A/G)CCCTG intron-variant
rs767786 -- 31,277,107(+) GCGCA(C/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B3GALTL Gene

Variant ID Type Subtype PubMed ID
esv2751142 CNV Gain 17911159
nsv528568 CNV Gain 19592680
nsv899963 CNV Loss 21882294
nsv899964 CNV Loss 21882294
esv1007096 CNV Deletion 20482838
nsv899965 CNV Gain 21882294
nsv64080 CNV Loss 16902084
nsv899966 CNV Gain 21882294
esv270309 CNV Insertion 20981092
esv273721 CNV Insertion 20981092

Relevant External Links for B3GALTL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GALTL Gene

Disorders for B3GALTL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for B3GALTL Gene in MalaCards »

(1) Diseases for B3GALTL Gene including...

(1) OMIM Diseases for B3GALTL Gene (610308)


  • Peters-plus syndrome (PpS) [MIM:261540]: Autosomal recessive disorder characterized by anterior eye-chamber abnormalities, disproportionate short stature, developmental delay, characteristic craniofacial features, cleft lip and/or palate. {ECO:0000269 PubMed:16909395}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for B3GALTL Gene

(1) Novoseek inferred disease relationships for B3GALTL Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for B3GALTL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with B3GALTL: view

No data available for Genatlas for B3GALTL Gene

Publications for B3GALTL Gene

  1. Molecular cloning and characterization of a novel human beta1,3- glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain. (PMID: 16899492) Sato T. … Narimatsu H. (Glycobiology 2006) 2 3 4
  2. A novel human glycosyltransferase: primary structure and characterization of the gene and transcripts. (PMID: 12943678) Heinonen T.Y.K. … Kainulainen H. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for B3GALTL Gene

Sources for B3GALTL Gene

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