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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B3GALT6 Gene

protein-coding   GIFtS: 56
GCID: GC01P001157

UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide...

(Previous names: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide 61 2 3     EDSP22
UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 61 2     SEMDJL12
Beta-1,3-GalTase 62 3     Beta-1,3-Galactosyltransferase 62
Galactosyltransferase II2 3     beta3Gal-T62
Galactosylxylosylprotein 3-Beta-Galactosyltransferase2 3     beta3GalT62
GAG GalTII2 3     Beta3Gal-T63
3-galactosyltransferase-61     Beta3GalT63
beta-11     EC 2.4.1.1343

External Ids:    HGNC: 179781   Entrez Gene: 1267922   Ensembl: ENSG000001760227   OMIM: 6152915   UniProtKB: Q96L583   

Export aliases for B3GALT6 gene to outside databases

Previous GC identifers: GC01P000694 GC01P000919 GC01P001044 GC01P001073 GC01P001207 GC01P000424


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for B3GALT6 Gene:
The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi
apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal
beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in
the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. (provided by RefSeq,
Jun 2013)

GeneCards Summary for B3GALT6 Gene: 
B3GALT6 (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6) is a protein-coding gene. Diseases associated with B3GALT6 include chancroid, and morquio syndrome b, and among its related super-pathways are Metabolic pathways and Metabolism of carbohydrates. GO annotations related to this gene include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity and galactosylxylosylprotein 3-beta-galactosyltransferase activity. An important paralog of this gene is B3GALNT2.

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal
beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region
of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with
terminal glucosamine or galactosamine residues




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B3GALT6 gene promoter:
         STAT1   AP-1   Sp1   Bach2   RelA   MIF-1   NF-kappaB   Pax-4a   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GALT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for B3GALT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GALT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

B3GALT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GALT6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001157:  view genomic region     (about GC identifiers)

Start:
1,167,629 bp from pter      End:
1,170,421 bp from pter
Size:
2,793 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58 (See protein sequence)
Recommended Name: Beta-1,3-galactosyltransferase 6  
Size: 329 amino acids; 37138 Da
Cofactor: Manganese
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein
Caution: PubMed:9892646 describes the wrong protein; the cDNAs used had been switched inadvertently
Secondary accessions: Q5T7M5

Explore the universe of human proteins at neXtProt for B3GALT6: NX_Q96L58

Explore proteomics data for B3GALT6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96L58

  • B3GALT6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    B3GALT6 Protein Expression
    REFSEQ proteins: NP_542172.2  
    ENSEMBL proteins: 
     ENSP00000368496  
    Reactome Protein details: Q96L58
    Human Recombinant Protein Products for B3GALT6: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005797Golgi medial cisterna IDA11551958
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    B3GALT6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    B3GT: Beta 3-glycosyltransferases

    1 InterPro protein domain:
     IPR002659 Glyco_trans_31

    Graphical View of Domain Structure for InterPro Entry Q96L58

    ProtoNet protein and cluster: Q96L58

    1 Blocks protein domain: IPB002659 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
    Similarity: Belongs to the glycosyltransferase 31 family


    B3GALT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3GT6_HUMAN, Q96L58
    Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal
    beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region
    of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with
    terminal glucosamine or galactosamine residues
    Catalytic activity: UDP-alpha-D-galactose + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein] = UDP +
    3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]

         Enzyme Number (IUBMB): EC 2.4.1.1341

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity ----
    GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IEA--
    GO:0035250UDP-galactosyltransferase activity IDA11551958
    GO:0047220galactosylxylosylprotein 3-beta-galactosyltransferase activity IEA--
         
    B3GALT6 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for B3GALT6 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    3A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    A tetrasaccharide linker sequence is required for GAG synthesis0.54
    4heparan sulfate biosynthesis
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    5chondroitin sulfate biosynthesis
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/19        Reactome Pathways for B3GALT6 (see all 19)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome


    3         Kegg Pathways  (Kegg details for B3GALT6):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
    Pathway: Glycan metabolism; chondroitin sulfate biosynthesis
    Pathway: Glycan metabolism; heparan sulfate biosynthesis


    B3GALT6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GALT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/24 Interacting proteins for B3GALT6 (Q96L583 ENSP000003684964) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013I2D: score=1 
    B3GAT1ENSP000003078754STRING: ENSP00000307875
    B3GAT2ENSP000002300534STRING: ENSP00000230053
    B3GAT3ENSP000002654714STRING: ENSP00000265471
    B4GALT7ENSP000000294104STRING: ENSP00000029410
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process IMP11551958
    GO:0006486protein glycosylation IEA--
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--

    B3GALT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for B3GALT6 (B3GT6)

    4 HMDB Compounds for B3GALT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Heparan sulfateHHS 5 (see all 13)9050-30-0--
    Manganesemanganese 7439-96-5--
    Poly-N-acetyllactosaminePoly(N-acetyllactosamine) (see all 6)82441-98-3--

    Search CenterWatch for drugs/clinical trials and news about B3GALT6 / B3GT6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for B3GALT6 gene: 
    NM_080605.3  

    Unigene Cluster for B3GALT6:

    UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
    Hs.284284  [show with all ESTs]
    Unigene Representative Sequence: NM_080605
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379198(uc001adk.3)
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    Additional mRNA sequence: 

    BC015549.1 BC041621.1 BC051719.1 

    3 DOTS entries:

    DT.451659  DT.75102664  DT.121376401 

    24/101 AceView cDNA sequences (see all 101):

    AA749073 AI220144 BE675787 BU624451 AI355607 BF590665 AA236572 AI890557 
    BC015549 AI924627 AI953613 AA729674 AI201722 CF145713 BM976581 BP340495 
    BU528237 CF145485 AI123578 AI278266 BF196927 AA358615 CD106998 CA425703 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    B3GALT6 expression in normal human tissues (normalized intensities)      B3GALT6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTTTGGT
    B3GALT6 Expression
    About this image


    B3GALT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells

    See B3GALT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for B3GALT6

    SOURCE GeneReport for Unigene cluster: Hs.284284

    UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for B3GALT6 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B3galt61 , 5 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide more1, 5 81.94(n)1
    85.14(a)1
      4 (87.66 cM)5
    1175921  NM_080445.41  NP_536693.11 
     1559894665 
    chicken
    (Gallus gallus)
    Aves B3GALT61 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide more 70.14(n)
    69.94(a)
      428185  XM_425743.2  XP_425743.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.187712 Transcribed sequence with moderate similarity to protein more 77.13(n)    BX769613.1 
    zebrafish
    (Danio rerio)
    Actinopterygii b3galt61 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide more 63.59(n)
    66.15(a)
      572324  NM_001045225.1  NP_001038690.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87343 chondroitin sulfate biosynthesis
    transferase, more
    42(a)   44D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A2AL.143
    sqv-21
    Protein SQV-21 42(a)3
    47.68(n)1
    44.37(a)1
      II(2889216-2894374)3
    1736351  NM_061993.41  NP_494394.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G210601 Galactosyltransferase family protein 39.71(n)
    34.35(a)
      827853  NM_001160788.1  NP_001154260.1 


    ENSEMBL Gene Tree for B3GALT6 (if available)
    TreeFam Gene Tree for B3GALT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for B3GALT6 gene
    B3GALNT22  

    B3GALT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/39 SNPs in B3GALT6 are shown (see all 39)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0593174
    ----see VAR_0593172 E D mis40--------
    rs455918401,2
    C,F--1169728(+) CATGGG/TTTTGG 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs794430111,2
    C--1169878(+) GACTGA/GAGGCG 1 -- ut310--------
    rs568529241,2
    C,F--1169973(+) TGGACG/AAGGAC 1 -- ut312Minor allele frequency- A:0.04WA NA 238
    rs1142089401,2
    F--1169980(+) GGACTC/TGTGAG 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1164495401,2
    C,F--1170005(+) GACCCC/TGGTGT 1 -- ut311Minor allele frequency- T:0.10WA 118
    rs1452653291,2
    --1170017(+) AGCAGA/GATGGG 1 -- ut310--------
    rs1475840421,2
    C--1170108(+) TTTTAC/TCTGGG 1 -- ut310--------
    rs613539801,2
    C,F--1170148(+) AGGAAC/TCCTGC 1 -- ut312Minor allele frequency- T:0.02WA NA 238
    rs1829760371,2
    --1170238(+) CCACAC/TCTCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for B3GALT6 (1167629 - 1170421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for B3GALT6 (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv470680CNV Loss18288195
    nsv871680CNV Loss21882294
    nsv482937CNV Loss15286789
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv21n71CNV Loss21882294
    nsv871965CNV Loss21882294
    dgv26n71CNV Loss21882294
    dgv11n71CNV Loss21882294
    dgv17n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): B3GALT6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing B3GALT6
    DNA2.0 Custom Variant and Variant Library Synthesis for B3GALT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615291    OMIM disorders: --

    2 diseases for B3GALT6:    About MalaCards
    chancroid    morquio syndrome b


    B3GALT6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): B3GALT6
    Human Genome Epidemiology (HuGE) Navigator: B3GALT6 (3 documents)

    Export disorders for B3GALT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for B3GALT6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with B3GALT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). (PubMed id 11551958)1, 2, 3, 9 Bai X.... Esko J.D. (2001)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. A beta-1,3-N-acetylglucosaminyltransferase with poly-N- acetyllactosamine synthase activity is structurally related to beta- 1,3-galactosyltransferases. (PubMed id 9892646)1, 2 Zhou D.... Hennet T. (1999)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. (PubMed id 12584198)9 Hwang H.Y....Horvitz H.R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126792 HGNC: 17978 AceView: B3GALT6 Ensembl:ENSG00000176022 euGenes: HUgn126792
    ECgene: B3GALT6 Kegg: 126792 H-InvDB: B3GALT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for B3GALT6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_433

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for B3GALT6 gene:
    Search GeneIP for patents involving B3GALT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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