V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

B3GALT6 Gene

protein-coding   GIFtS: 50

GC01P001157
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
(Previous names: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
EC 2.4.1.134 3
OTTHUMP00000001756 2
beta3GalT6 1, 2
Descriptions
GAG GalTII 3
Galactosyltransferase II 3
Galactosylxylosylprotein 3-beta-galactosyltransferase 3
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide
6 2, 3
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase,
polypeptide 6 1, 2
beta 3GalT6 3
beta-1,3-galactosyltransferase 6 2
External Ids
HGNC: 179781
Entrez Gene: 1267922
UniProtKB: Q96L583
Ensembl: ENSG000001760227
Search outside databases for aliases for B3GALT6 gene

Previous GC identifers: GC01P000694 GC01P000919 GC01P001044 GC01P001073 GC01P001207

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates
with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that
is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin
sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the B3GALT6 gene  

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

B3GALT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001157:     (about GC identifiers)

Start:
1,157,492 bp from pter
End:
1,160,284 bp from pter
Size:
2,793 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_004350.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58 (See protein sequence)
Recommended Name: Beta-1,3-galactosyltransferase 6  
Size: 329 amino acids; 37138 Da
Cofactor: Manganese
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein
Caution: PubMed:9892646 describes the wrong protein; the cDNAs used had been switched inadvertently
Secondary accessions: Q5T7M5

REFSEQ proteins: NP_542172.2  

ENSEMBL proteins: 
ENSP00000368496 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (B3GALT6)
Human Recombinant Proteins from Abnova (B3GALT6)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005794 Golgi apparatus IEA--
GO:0005797 Golgi medial cisterna IDA11551958
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

Antibodies for B3GALT6: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for B3GALT6
Browse R&D Systems for Antibodies
Antibodies from Abcam (B3GALT6), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (B3GALT6)
Novus Biologicals Antibodies for B3GALT6

Assays for B3GALT6: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro domain/family:
 IPR002659 Glyco_trans_31


   GeneDecks  B3GALT6 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96L58

ProtoNet protein and cluster: Q96L58

1 Blocks protein family: IPB002659 Glycosyl transferase

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
Similarity: Belongs to the glycosyltransferase 31 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (B3GALT6)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (B3GALT6)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080605

              Applied Biosystems Silencer® siRNAs for B3GALT6

              Sigma-Aldrich siRNA for B3GALT6  
                     Sigma-Aldrich shRNA for B3GALT6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080605
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_080605
                                 untagged cDNA clone in CMV expression vector: NM_080605 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_080605

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates
with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that
is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin
sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues
Catalytic activity: UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP +
3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
Enzyme Number (IUBMB): EC 2.4.1.134 

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IEA--
GO:0016757 transferase activity, transferring glycosyl groups IEA--
GO:0030145 manganese ion binding IEA--
GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Sigma-Aldrich "Your Favorite Gene" Pathway for  B3GALT6  (Your Favorite Gene powered by Ingenuity) 
 Chondroitin Sulfate Biosynthesis

   GeneDecks  B3GALT6 for the pathways selected above  
About GeneDecksing

2 Kegg Pathways  (Kegg details for B3GALT6):
 hsa00532 Chondroitin sulfate biosynthesis
 hsa00534 Heparan sulfate biosynthesis

   GeneDecks  B3GALT6 for the pathways selected above  
About GeneDecksing
UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
Pathway: Glycan metabolism; chondroitin sulfate biosynthesis
Pathway: Glycan metabolism; heparan sulfate biosynthesis

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process IMP11551958
GO:0006486 protein amino acid glycosylation IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for B3GALT6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (B3GALT6)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (B3GALT6)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080605

              Sigma-Aldrich siRNA for B3GALT6  
                     Sigma-Aldrich shRNA for B3GALT6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_080605  

REFSEQ mRNAs for B3GALT6 gene: 

NM_080605.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_080605  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080605
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_080605
                                 untagged cDNA clone in CMV expression vector: NM_080605 

Additional cDNA sequence: 

BC015549.1 BC041621.1 BC051719.1 

3 DOTS entries:

DT.451659  DT.75102664  DT.121376401 

24/101 AceView cDNA sequences (see all 101 ):

BE675787 AI924627 BM976581 BC041621 AA729674 BC015549 BU624451 BP340495 
AI953613 BF196927 AA236572 AI201722 AI278266 AI220144 CF145485 BU528237 
AI890557 AA749073 AI123578 CF145713 CD106998 AI355607 BF590665 CA425703 

highest scoring ESTs for B3GALT6:

AI890557 AA010543 AA085121 AA152191 AA236572 AA247178 AA247942 AA306012 AA358615 AA360059 

Unigene Cluster for B3GALT6:

UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
Hs.284284  [show with all ESTs]
Unigene Representative Sequence: NM_080605


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000379198  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

B3GALT6 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for B3GALT6

1 / 2 / 3

4 probe-sets matching B3GALT6 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

49058_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI890557 1.00 1.00 1.00 1

225733_at2, 3 U133-B 1 1.00 1.00 -- -- AI890557 1.00 1.00 1.00 1

225733_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1553959_a_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGATTTTGGT

SOURCE GeneReport for Unigene cluster: Hs.284284

UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58
Tissue specificity: Ubiquitous

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for B3GALT6 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
B3GALT61   -- UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide more 99.19(n)
98.78(a)
457187  XM_513707.2  XP_513707.1 
cow
(Bos taurus)
B3GALT61   -- UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide more 87.56(n)
90.21(a)
522406  XM_600686.3  XP_600686.1 
rat
(Rattus norvegicus)
B3galt61   -- UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide more 79.46(n)
85.76(a)
298690  XM_233721.3  XP_233721.1 
mouse
(Mus musculus)
B3galt61, 5 45
UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide more1, 5 81.94(n)1
85.14(a)1
1175921  NM_080445.31  NP_536693.11 
 AK0336085  AK0780835  (see all 15)
chicken
(Gallus gallus)
B3GALT61   -- UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide more 70.14(n)
69.94(a)
428185  XM_425743.2  XP_425743.1 
About this table        Species with no ortholog for B3GALT6

ENSEMBL Gene Tree for B3GALT6
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for B3GALT6 gene
B3GALNT22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


6 NCBI SNPs in B3GALT6 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs455911321,2
--1159278(+) CCGCCG/TTAAGA 1 -- ut310--------
--
rs455788471,2
--1159348(+) CCCTCA/GTTTAA 1 -- ut310--------
--
rs568529241,2
--1159836(+) TGGACA/GAGGAC 1 -- ut310--------
--
rs455918401,2
--1159591(+) CATGGG/TTTTGG 1 -- ut310--------
--
rs613539801,2
--1160011(+) AGGAAC/TCCTGC 1 -- ut310--------
--
rs594201861,2
--1160464(+) TCGACC/TGTGCA 1 -- ng310--------
About this table
The following additional 27 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs12249 rs2297864 rs3766189 rs3813196 rs3949751 rs11260562 rs12410680
 rs61745645 rs6603781 rs61744664 rs3766187 rs4970423 rs28499162 rs6675798
 rs61745652 rs3753342 rs6702268 rs7515488 rs35279523 rs35194949 rs4970364
 rs715643 rs61743559 rs3753343 rs3766188 rs3766186 rs3813199

HapMap Linkage Disequilibrium images for B3GALT6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for B3GALT6 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 126792 HGNC: 17978 AceView: B3GALT6 Ensembl:ENSG00000176022 euGenes: HUgn126792
ECgene: B3GALT6 H-InvDB: B3GALT6
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT6
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_433
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for B3GALT6:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for B3GALT6-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for B3GALT6 Antibodies for B3GALT6
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for B3GALT6 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (B3GALT6)
 Antibodies (B3GALT6)
 Chimera RNAi (B3GALT6)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(B3GALT6)
 Antibodies (B3GALT6)
 Search OriGene for B3GALT6
 Search Tocris compounds for B3GALT6




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for B3GALT6

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
B3GALT6 Gene at Home site.
Version 2.41.1
server5.xennexinc.com