Aliases for B3GALT6 Gene
- Beta-1,3-Galactosyltransferase 6 2 3 5
- UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide 6 2 3 4
- UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 6 2 3
- Galactosylxylosylprotein 3-Beta-Galactosyltransferase 3 4
- UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase 6 2 3
- Galactosyltransferase II 3 4
- Beta-1,3-GalTase 6 3 4
- Beta3Gal-T6 3 4
External Ids for B3GALT6 Gene
Previous GeneCards Identifiers for B3GALT6 Gene
The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013]
GeneCards Summary for B3GALT6 Gene
B3GALT6 (Beta-1,3-Galactosyltransferase 6) is a Protein Coding gene. Diseases associated with B3GALT6 include Ehlers-Danlos Syndrome, Progeroid Type, 2 and Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 1, With Or Without Fractures. Among its related pathways are Defective B4GALT7 causes EDS, progeroid type and Metabolism. GO annotations related to this gene include galactosyltransferase activity and UDP-galactosyltransferase activity. An important paralog of this gene is B3GALNT2.
UniProtKB/Swiss-Prot for B3GALT6 Gene
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.