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Aliases & Descriptions for B3GALT6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.4.1.134 3 | | OTTHUMP00000001756 2 | | beta3GalT6 1, 2 |
| | | Descriptions |
|---|
| GAG GalTII 3 | | Galactosyltransferase II 3 | | Galactosylxylosylprotein 3-beta-galactosyltransferase 3 | UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 2, 3 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6 1, 2 | | beta 3GalT6 3 | | beta-1,3-galactosyltransferase 6 2 |
|
| | Search outside databases for aliases for B3GALT6 genePrevious GC identifers: GC01P000694 GC01P000919 GC01P001044 GC01P001073 GC01P001207 |
Summaries for B3GALT6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues |
Genomic Location for B3GALT6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B3GALT6 gene 
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33B3GALT6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P001157:
(about GC identifiers)
Start:
|
1,157,492 bp from pter |
End:
|
1,160,284 bp from pter |
Size:
|
2,793 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004350.18
| Proteins for B3GALT6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58 (See
protein sequence)Recommended Name: Beta-1,3-galactosyltransferase 6 Size: 329 amino acids; 37138 Da
Cofactor: Manganese
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein
Caution: PubMed:9892646 describes the wrong protein; the cDNAs used had been switched inadvertently
Secondary accessions: Q5T7M5REFSEQ proteins: NP_542172.2
ENSEMBL proteins: ENSP00000368496
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B3GALT6: Assays for B3GALT6: | Protein
Domains/ Families for B3GALT6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96L58
ProtoNet protein and cluster: Q96L58 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58Similarity: Belongs to the glycosyltransferase 31 family | Gene Function for B3GALT6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080605
Applied Biosystems Silencer® siRNAs for B3GALT6
Sigma-Aldrich siRNA for B3GALT6  Sigma-Aldrich shRNA for B3GALT6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080605                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080605                                  untagged cDNA clone in CMV expression vector: NM_080605 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080605
UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residuesCatalytic activity: UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylproteinEnzyme Number (IUBMB): EC 2.4.1.134 4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
IEA | -- | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | | GO:0030145 | manganese ion binding |
IEA | -- | | GO:0047220 | galactosylxylosylprotein 3-beta-galactosyltransferase activity |
IEA | -- | About this table | Pathways & Interactions for B3GALT6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for B3GALT6 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58Pathway: Glycan metabolism; chondroitin sulfate biosynthesisPathway: Glycan metabolism; heparan sulfate biosynthesis2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006024 | glycosaminoglycan biosynthetic process |
IMP | 11551958 | | GO:0006486 | protein amino acid glycosylation |
IEA | -- | About this table
|
Drugs & Compounds for B3GALT6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B3GALT6
|
Transcripts for B3GALT6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080605
Sigma-Aldrich siRNA for B3GALT6  Sigma-Aldrich shRNA for B3GALT6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_080605 REFSEQ mRNAs for B3GALT6 gene: NM_080605.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_080605               OriGene GFP tagged cDNA clone in CMV expression vector: NM_080605                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080605                                  untagged cDNA clone in CMV expression vector: NM_080605  Additional cDNA sequence: BC015549.1 BC041621.1 BC051719.1 3 DOTS entries: DT.451659 DT.75102664 DT.121376401 24/101 AceView cDNA sequences (see all 101
):BE675787 AI924627 BM976581 BC041621 AA729674 BC015549 BU624451 BP340495 AI953613 BF196927 AA236572 AI201722 AI278266 AI220144 CF145485 BU528237 AI890557 AA749073 AI123578 CF145713 CD106998 AI355607 BF590665 CA425703
highest scoring ESTs for B3GALT6:AI890557 AA010543 AA085121 AA152191 AA236572 AA247178 AA247942 AA306012 AA358615 AA360059 Unigene Cluster for B3GALT6: UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 Hs.284284 [show with all ESTs]Unigene Representative Sequence: NM_080605
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000379198
|
Expression for B3GALT6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B3GALT6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B3GALT6
1 / 2 / 3 4 probe-sets matching B3GALT6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGATTTTGGT
SOURCE GeneReport for Unigene cluster: Hs.284284 UniProtKB/Swiss-Prot: B3GT6_HUMAN, Q96L58Tissue specificity: Ubiquitous |
Orthologs for B3GALT6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B3GALT6 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for B3GALT6
ENSEMBL Gene Tree for B3GALT6 | Paralogs for B3GALT6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B3GALT6 gene
- B3GALNT22
|
SNPs/Variants for B3GALT6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 27 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for B3GALT6 (up to first 250kb)
|
Disorders & Mutations for B3GALT6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for B3GALT6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B3GALT6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for B3GALT6 gene:- Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). (PubMed id 11551958)1, 2, 3, 4 Bai X.... Esko J.D. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- A beta-1,3-N-acetylglucosaminyltransferase with poly-N- acetyllactosamine synthase activity is structurally related to beta- 1,3-galactosyltransferases. (PubMed id 9892646)3, 4 Zhou D.... Hennet T. (1999)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. (PubMed id 12584198)1 Hwang H.Y....Horvitz H.R. (2003)
|
Search for B3GALT6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B3GALT6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B3GALT6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GALT6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT6 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_433 |
|
| | | About This Section
| --
| Services for B3GALT6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for B3GALT6:

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Incremental update: 13 Oct 2009
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