Aliases for B3GALT6 Gene
- Beta-1,3-Galactosyltransferase 6 2 3 5
- UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase Polypeptide 6 2 3 4
- UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 6 2 3
- Galactosylxylosylprotein 3-Beta-Galactosyltransferase 3 4
- UDP-Gal:BetaGal Beta 1,3-Galactosyltransferase 6 2 3
- Galactosyltransferase II 3 4
- Beta-1,3-GalTase 6 3 4
- Beta3Gal-T6 3 4
External Ids for B3GALT6 Gene
Previous GeneCards Identifiers for B3GALT6 Gene
The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013]
GeneCards Summary for B3GALT6 Gene
B3GALT6 (Beta-1,3-Galactosyltransferase 6) is a Protein Coding gene. Diseases associated with B3GALT6 include Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 1, With Or Without Fractures and Ehlers-Danlos Syndrome, Progeroid Type, 2. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include galactosyltransferase activity and UDP-galactosyltransferase activity. An important paralog of this gene is B3GALNT2.
UniProtKB/Swiss-Prot for B3GALT6 Gene
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.