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Aliases & Descriptions for B3GALT5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase , and/or 9 Nature :405,311-319 and CroW21)About This Section
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Aliases B3GalT-V 1 , 2 B3GalTx 2 B3T5 1 , 2 Beta-3-Gx-T5 3 Beta3Gal-T5 3 EC 2.4.1.- 3 GLCT5 1 , 2 , 5 OTTHUMP00000109185 2 OTTHUMP00000109186 2 b3Gal-T5 3 beta3Gal-T5 1 , 2
Descriptions Beta-1,3-GalTase 5 3 GlcNAc-beta-1,3-galactosyltransferase 5 2 , 9 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5 3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 5 2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5 3 homolog of C. elegans Bt toxin resistance gene bre-5 2
Search outside databases for aliases for B3GALT5 genePrevious GC identifers: GC21P037603 GC21P039950 GC21P039951
Summaries for B3GALT5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for B3GALT5 : This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This familyencodes type II membrane-bound glycoproteins with diverse enzymatic functions using differentdonor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars(N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly relatedto the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon.The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalTproteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereasbeta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changesduring embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups:beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the mostprobable candidate for synthesis of the type 1 Lewis antigens which are frequently found to beelevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linkedglycoproteins and functions in mucin glycosylation. Five transcript variants have been describedwhich differ in the 5' UTR. All transcript variants encode an identical protein. [provided byRefSeq] UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 Function : Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficientacceptor
Gene Wiki entry for B3GALT5
Genomic Location for B3GALT5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.2 HGNC cytogenetic band: 21q22.3 Nature(405: 311-319) cytogenetic band: 21q22.2 B3GALT5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
GC21P039949:
GeneLoc
Nature :405,311-319
Start:
39,850,239 bp from pter
26,602,223 bp from centromere
End:
39,956,686 bp from pter
26,607,784 bp from centromere
Size:
106,448 bases
5,562 bases
Orientation:
plus strand
plus strand
RefSeq DNA sequence: NC_000021.7 NT_011512.10 Whole chromosome sequencing:
cDNA sequence:
AB020337 genomic clones:
P70I24
Proteins for B3GALT5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 (See
protein sequence )Recommended Name: Beta-1,3-galactosyltransferase 5 Size : 310 amino acids; 36189 Da
Subcellular location : Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions : Q2M3L5 Q53Z19 Q9NY96 Q9P1X6 Q9P1X7
REFSEQ proteins (5 alternative transcripts):
NP_006048.1 NP_149360.1 NP_149361.1 NP_149362.1 NP_149363.1 ENSEMBL proteins: ENSP00000343318 ENSP00000369992 ENSP00000369994 ENSP00000381699 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for B3GALT5: Assays for B3GALT5:
Protein
Domains/ Families for B3GALT5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9Y2C3 ProtoNet protein and cluster: Q9Y2C3
1 Blocks protein family : IPB002659 Glycosyl transferase UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 Similarity : Belongs to the glycosyltransferase 31 family
Gene Function for B3GALT5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_033170 Applied Biosystems Silencer ® siRNAs for B3GALT5 Sigma-Aldrich siRNA for B3GALT5 Sigma-Aldrich shRNA for B3GALT5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_006057                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_006057                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_006057  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006057 UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 Function : Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficientacceptor Enzyme Number (IUBMB): EC 2.4.1.-
Genatlas biochemistry entry for B3GALT5 :UDP galactose
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for B3galt5) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008378 galactosyltransferase activity
IEA -- GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
TAS 10212226 GO:0016757 transferase activity, transferring glycosyl groups
IEA --
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Pathways & Interactions for B3GALT5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 Pathway : Protein modification; protein glycosylation
5/28 Interacting proteins for B3GALT5 (ENSP00000369992 3 ) via UniProtKB, MINT, and/or STRING (see all 28
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006486 protein amino acid glycosylation
TAS 10212226
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Drugs & Compounds for B3GALT5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for B3GALT5
Transcripts for B3GALT5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_033170 Sigma-Aldrich siRNA for B3GALT5 Sigma-Aldrich shRNA for B3GALT5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_006057 NM_033170 NM_033171 NM_033172 NM_033173
REFSEQ mRNAs for B3GALT5 gene (5 alternative transcripts): NM_006057.1 NM_033170.1 NM_033171.1 NM_033172.1 NM_033173.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006057 NM_033170 NM_033171 NM_033172 NM_033173
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_006057                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_006057                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_006057  
Additional cDNA sequence: AB020337.1 AK292951.1 AY372061.1 BC104862.1 BC104864.1 DQ645732.1 DQ645733.1 DQ645734.1 DQ645735.1 DQ645736.1 DQ645737.1 DQ645738.1
6 DOTS entries : DT.100017759 DT.70100727 DT.121129535 DT.100017758 DT.101979765 DT.121129542
14 AceView cDNA sequences :NM_033170 AW136254 NM_033173 AY372061 NM_033172 NM_033171 NM_006057 AB020337 BM674032 BM715577 BX281941 AI739518 BF366265 AU100432
highest scoring ESTs for B3GALT5 :AB020337 AI739518 AJ003597 AW136254 AY372061 BE699666 BF748181 NM_006057 NM_033170 NM_033171
Unigene Cluster for B3GALT5: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 Hs.655094 [show with all ESTs ] Unigene Representative Sequence: NM_033173 GeneLoc Exon Structure 4 Ensembl transcripts including schematic representations : ENST00000343118
ENST00000380618
ENST00000380620
ENST00000398714
Expression for B3GALT5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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B3GALT5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for B3GALT5 1 / 2 / 3
3 probe-sets matching B3GALT5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.655094 Expression variation in blood from EXPOLDB for B3GALT5
UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 Tissue specificity : Expressed in stomach, jejunum, colon, pancreas, small intestine, testis andgastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal glandand peripheral blood leukocytes
Orthologs for B3GALT5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for B3GALT5 gene from 5/10 species (see all 10
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
B3GALT51
--
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more
78.17(n) 76.77(a)
487766 XM_544891.2 XP_544891.2
chimpanzee (Pan troglodytes)
B3GALT51
--
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more
98.39(n) 97.42(a)
474117 XM_001171374.1 XP_001171374.1
cow (Bos taurus)
B3GALT51
--
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more
75.65(n) 67.86(a)
614873 XM_866515.2 XP_871608.2
rat (Rattus norvegicus)
B3galt51
--
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more
75.35(n) 71.66(a)
288161 XM_221525.4 XP_221525.4
mouse (Mus musculus)
B3galt51 , 5
165
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more 1, 5
74.38(n) 1 72.64(a) 1
93961 1 NM_033149.2 1 NP_149161.1 1 AF254738 5 AI451229 5 (see all 16 )
About this table Species with no ortholog for B3GALT5 ENSEMBL Gene Tree for B3GALT5 Paralogs for B3GALT5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for B3GALT5 gene B3GALT2 2 B3GALNT1 2 B3GALT1 2
SNPs/Variants for B3GALT5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for B3GALT5 (up to first 250kb)
Disorders & Mutations for B3GALT5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604066
Medical News for B3GALT5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for B3GALT5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/19 PubMed articles for B3GALT5 gene (see all 19
): Cloning, expression, and characterization of a novel UDP- galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. (PubMed id 10212226) 1, 2, 3, 4 Isshiki S....Narimatsu H. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. (PubMed id 14534330) 3, 4 Dunn C.A.... Mager D.L. (2003) The DNA sequence of human chromosome 21. (PubMed id 10830953) 3, 4 Hattori M....Yaspo M.L. (2000) Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128) 3, 4 Amado M.... Clausen H. (1999) Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme. (PubMed id 10406968) 3, 4 Zhou D.... Hennet T. (1999) Beta1,3-galactosyltransferases-4/5 are novel tumor markers for gynecological cancers. (PubMed id 19225246) 3 Seko A....Yamashita K. (2009) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588) 3 Hu Y.H....Janitz M. (2006) Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5. (PubMed id 16112824) 3 Dunn C.A....Mager D.L. (2005) Transcriptional regulation of the human beta-1,4- galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1. (PubMed id 15263012) 3 Sato T. and Furukawa K. (2004)
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Genome Databases showing B3GALT5
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing B3GALT5
(According to HUGE )
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--
Specialized Databases showing B3GALT5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
ATLAS Chromosomes in Cancer entry for B3GALT5 Genetics and Cytogenetics in Oncology and Haematology GGDB http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT5 Functional Glycomics Gateway - GTase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_432
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-- Services for B3GALT5 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for B3GALT5:
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Aliases for B3GALT5
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Drugs/Compounds for B3GALT5
Expression for B3GALT5
Function for B3GALT5
Location for B3GALT5
Medical News for B3GALT5
Orthologs for B3GALT5
Paralogs for B3GALT5
Pathways/Interactions for B3GALT5
Proteins for B3GALT5
Publications for B3GALT5
SNPs for B3GALT5
Search Box for B3GALT5
Services for B3GALT5
Summaries for B3GALT5
Technologies for B3GALT5
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009