Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B3GALT5 Gene

protein-coding   GIFtS: 55
GCID: GC21P040928

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide...

 Explore 5 diseases affiliated with
B3GALT5 via our new
 Human Malady Compendium 
Biological research products
for B3GALT5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 51 2     B3GalTx2
GLCT51 2 5     Beta-1,3-Galactosyltransferase 52
B3GalT-V1 2     Beta-3-Gx-T53
B3T51 2     Beta3GalT53
Beta3Gal-T53     Homolog Of C. Elegans Bt Toxin Resistance Gene Bre-52
GlcNAc-Beta-1,3-Galactosyltransferase 52 11     Beta-3-Gx-T53
Beta-1,3-GalTase 52 3     Beta3Gal-T53
B3Gal-T51     Beta3GalT53
UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 52 3     EC 2.4.1.-3
UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 52 3     EC 2.4.18

External Ids:    HGNC: 9201   Entrez Gene: 103172   Ensembl: ENSG000001837787   OMIM: 6040665   UniProtKB: Q9Y2C33   

Export aliases for B3GALT5 gene to outside databases

Previous GC identifers: GC21P037603 GC21P039950 GC21P039949 GC21P039951 GC21P026498


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for B3GALT5:
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II
membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and
UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The
beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained
in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT
proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes
synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence
similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3,
beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are
frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with
N-linked glycoproteins and functions in mucin glycosylation. Alternatively spliced transcript variants encoding the
same protein have been observed for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
Function: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan
GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor

Gene Wiki entry for B3GALT5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B3GALT5 gene promoter:
         Max1   RP58   p53   Lmo2   FOXL1   RORalpha1   SRY   Sox9   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GALT5 promoter sequence

   Search SABiosciences Chromatin IP Primers for B3GALT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GALT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
B3GALT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GALT5 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040928:   GeneLoc Nature:405,311-319
Start:
40,928,369 bp from pter       26,602,223 bp from centromere
End:
41,034,816 bp from pter 26,607,784 bp from centromere
Size:
106,448 bases 5,562 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB020337
genomic clones: P70I24


(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 (See protein sequence)
Recommended Name: Beta-1,3-galactosyltransferase 5  
Size: 310 amino acids; 36189 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: A8KA86 D3DSI3 Q2M3L5 Q53Z19 Q9NY96 Q9P1X6 Q9P1X7

Explore the universe of human proteins at neXtProt for B3GALT5: NX_Q9Y2C3

4/8 DME Specific Peptides for B3GALT5 (Q9Y2C3) (see all 8)
 VMKTDSD  TTRFFTG  FCSGTGY  AIRQTWG 

B3GALT5 Protein expression data from MOPED and PaxDb:    About this image 
B3GALT5 Protein Expression
REFSEQ proteins (4 alternative transcripts): 
NP_006048.1  NP_149360.1  NP_149361.1  NP_149362.1  

ENSEMBL proteins: 
 ENSP00000369994   ENSP00000369992   ENSP00000343318   ENSP00000381699  

Human Recombinant Protein Products for B3GALT5: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: B3GALT5
OriGene Protein Over-expression Lysate (see all 9): B3GALT5
OriGene Custom Protein Services for B3GALT5 
GenScript Custom Purified and Recombinant Proteins Services for B3GALT5
Novus Biologicals B3GALT5 Protein
Novus Biologicals B3GALT5 Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005783endoplasmic reticulum IDA16780588
GO:0005794Golgi apparatus IDA16780588
GO:0016021integral to membrane IEA--

B3GALT5 for ontologies           About GeneDecksing



B3GALT5 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for B3GALT5 
GenScript Custom Superior Antibodies Services for B3GALT5
Novus Biologicals B3GALT5 Antibody
Search for Antibodies for B3GALT5 at Abcam  
Browse Antibodies at Uscn
ThermoFisher Antibodies for B3GALT5

Assay Products for B3GALT5: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for B3GALT5
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

B3GALT5 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002659 Glyco_trans_31

Graphical View of Domain Structure for InterPro Entry Q9Y2C3

ProtoNet protein and cluster: Q9Y2C3

1 Blocks protein family: IPB002659 Glycosyl transferase

UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
Similarity: Belongs to the glycosyltransferase 31 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: B3GT5_HUMAN, Q9Y2C3
Function: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan
GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor

     Genatlas biochemistry entry for B3GALT5:
UDP galactose

     Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS10212226
     
B3GALT5 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for B3galt5):
 normal 

B3GALT5 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for B3GALT5 

miRNA
Products:
    
Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat B3GALT5
6 QIAGEN miScript miRNA Assays for microRNAs that regulate B3GALT5:
hsa-miR-4291 hsa-miR-4303 hsa-miR-3155 hsa-miR-24 hsa-miR-3155b hsa-miR-484
SwitchGear 3'UTR luciferase reporter plasmidB3GALT5 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GALT5 (see all 7)
OriGene shRNA RFP: B3GALT5
OriGene siRNA: B3GALT5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GALT5
Sirion Biotech Custom design and validation of potent shRNA sequences against B3GALT5 

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for B3GALT5
Sirion Biotech Customized adenovirus for overexpression of B3GALT5 
Sirion Biotech Customized adenovirus for potent knockdown of B3GALT5

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GALT5 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GALT5 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 5): B3GALT5 (NM_006057)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GALT5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GALT5 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for B3GALT5
Search LifeMap BioReagents cell lines for B3GALT5
Sirion Biotech Customized stable knockdown cell line services for B3GALT5 
Sirion Biotech Customized inducible knockdown cell line services for B3GALT5
Sirion Biotech Customized stable overexpressing cell line services for B3GALT5
Sirion Biotech Customized inducible overexpressing cell line services for B3GALT5

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT5


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - lacto and neolacto series1.00
2Glycosphingolipid biosynthesis - globo series
Glycosphingolipid biosynthesis - globo series1.00
3Metabolism
Metabolic pathways0.38

Pathway sources
See GeneCards unified pathways
Show all pathways



3         Kegg Pathways  (Kegg details for B3GALT5):
    Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo series
Metabolic pathways

UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
Pathway: Protein modification; protein glycosylation


B3GALT5 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B3GALT5

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for B3GALT5 (ENSP000003433184) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

InteractantInteraction Details
GeneCardExternal ID(s)
B3GALNT1ENSP000003234794STRING: ENSP00000323479
B4GALT1ENSP000003690554STRING: ENSP00000369055
FUT1ENSP000003120214STRING: ENSP00000312021
FUT2ENSP000003757484STRING: ENSP00000375748
FUT3ENSP000003056034STRING: ENSP00000305603
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006486protein glycosylation IEA--

B3GALT5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for B3GALT5

10/519 HMDB Compounds for B3GALT5 (see all 519)    About this table
CompoundSynonyms CAS #PubMed Ids
3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
Search CenterWatch for drugs/clinical trials and news about B3GALT5 / B3GT5 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for B3GALT5 gene (5 alternative transcripts): 
NM_006057.1  NM_033170.1  NM_033171.1  NM_033172.1  NM_033173.1  

Unigene Cluster for B3GALT5:

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
Hs.733638  [show with all ESTs]
Unigene Representative Sequence: AY372061
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380620(uc002yyf.1 uc002yyg.1 uc002yyh.1 uc002yyb.1)
ENST00000475838 ENST00000380618(uc002yyi.1 uc002yyj.1 uc002yyk.1 uc002yyl.1 uc002yym.1)
ENST00000343118(uc010gom.1 uc002yye.2) ENST00000398714

miRNA
Products:
     
Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat B3GALT5
6 QIAGEN miScript miRNA Assays for microRNAs that regulate B3GALT5:
hsa-miR-4291 hsa-miR-4303 hsa-miR-3155 hsa-miR-24 hsa-miR-3155b hsa-miR-484
SwitchGear 3'UTR luciferase reporter plasmidB3GALT5 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GALT5 (see all 7)
OriGene shRNA RFP: B3GALT5
OriGene siRNA: B3GALT5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GALT5
Sirion Biotech Custom design and validation of potent shRNA sequences against B3GALT5 
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GALT5 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GALT5 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 5): B3GALT5 (NM_006057)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GALT5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GALT5 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GALT5
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B3GALT5
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GALT5
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GALT5

Additional cDNA sequence: 

AB020337.1 AK292951.1 AY372061.1 BC104862.1 BC104864.1 DQ645732.1 DQ645733.1 DQ645734.1 
DQ645735.1 DQ645736.1 DQ645737.1 DQ645738.1 

5 DOTS entries:

DT.100017759  DT.70100727  DT.121129535  DT.100017758  DT.101979765 

14 AceView cDNA sequences:

NM_006057 NM_033170 AY372061 AW136254 NM_033173 NM_033172 AB020337 NM_033171 
BM715577 BX281941 AI739518 BM674032 BF366265 AU100432 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

B3GALT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
B3GALT5 Expression
About this image

B3GALT5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
OvaryPrimary FollicleGranulosa CellsOvary
OvaryPrimordial FolliclePre-Granulosa CellsOvary
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See B3GALT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for B3GALT5

SOURCE GeneReport for Unigene cluster: Hs.733638

UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
Tissue specificity: Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and
pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes

    SABiosciences Custom PCR Arrays for B3GALT5
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GALT5
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B3GALT5
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GALT5
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GALT5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for B3GALT5 gene from 6/18 species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves B3GALT51 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more 64.61(n)
62.93(a)
  427985  XM_425555.3  XP_425555.3 
lizard
(Anolis carolinensis)
Reptilia --
--
--
61(a)
51(a)
1 ↔ many
1 ↔ many
3(139533568-139534482)
3(139511258-139513504)
African clawed frog
(Xenopus laevis)
Amphibia Xl.162522 Xenopus laevis transcribed sequence with weak similarity more 74.38(n)    BJ632719.1 
fruit fly
(Drosophila melanogaster)
Insecta CG86683
CG86731
UDP-galactose beta-N-acetylglucosamine
beta-1,3-galactosyltransferase3
CG86731
35(a)
(best of 2)3
49.78(n)1
40.97(a)1
  28E73
341051  NM_135338.21  NP_609182.11 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G064401 putative beta-1,3-galactosyltransferase 16 41.49(n)
31.54(a)
  819820  NM_111519.2  NP_566284.1 
rice
(Oryza sativa)
Liliopsida Os01g03289001 hypothetical protein 42.15(n)
29.75(a)
  4326981  NM_001049454.1  NP_001042919.1 


ENSEMBL Gene Tree for B3GALT5 (if available)
TreeFam Gene Tree for B3GALT5 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for B3GALT5 gene
B3GNT32  B3GNT22  B3GNT52  B3GALT12  B3GNT42  B3GALT42  B3GNT72  B3GALT22  
B3GNT82  B3GNT62  B3GALNT12  B3GNT92  
9 SIMAP similar genes for B3GALT5 using alignment to 1 protein entry:     B3GT5_HUMAN:
OK/KNS-cl.1    B3GALT2    B3GALNT1    B3GALT1    B3GNT5    B3GNT3
B3GNT6    B3GNT8    B3GNT7

B3GALT5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/176 NCBI SNPs in B3GALT5 are shown (see all 176    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs732155021,2
C--26498877(+) TATCTG/ATCTGT 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1860172121,2
--41027441(+) TTCTTA/CATTAC 4 -- us2k10--------
rs1468701541,2
--41027505(+) TTGAGC/GCCAGG 4 -- us2k10--------
rs22393851,2
C,F,A,H--41027747(+) GACACA/GGGAGT 4 -- us2k136Minor allele frequency- G:0.45EA NS NA WA CSA 4639
rs22393861,2
C,F,A,H--41027823(+) CCTTCT/CCCAGG 4 -- us2k110Minor allele frequency- C:0.44EA NA WA CSA 1878
rs110884911,2
C,F,A,H--41027854(+) GTACAA/GCGAAT 4 -- us2k111Minor allele frequency- G:0.10EA NA 618
rs169980871,2
C,F--41027864(+) TCCACT/GGAAAT 4 -- us2k18Minor allele frequency- G:0.11NA WA CSA 267
rs1407043921,2
--41027902(+) CTTCGA/GCCTTG 4 -- us2k10--------
rs1445429391,2
--41028079(+) CAAGCC/TTCCCG 4 -- us2k10--------
rs762272641,2
--41028141(+) AGGGAC/TGTTGA 4 -- us2k11Minor allele frequency- T:0.01NA 120

HapMap Linkage Disequilibrium report for B3GALT5 (40928369 - 41034816 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for B3GALT5: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GALT5
DNA2.0 Custom Variant and Variant Library Synthesis for B3GALT5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

B3GALT5 for disorders           About GeneDecksing

OMIM gene information: 604066    OMIM disorders: --

5 diseases for B3GALT5:    About MalaCards
pancreatic cancer    pancreatitis    colon carcinoma    immunodeficiency
carcinoma

Human Genome Epidemiology (HuGE) Navigator: B3GALT5 (1 document)

Export disorders for B3GALT5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for B3GALT5 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with B3GALT5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, expression, and characterization of a novel UDP- galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. (PubMed id 10212226)1, 2, 3, 9 Isshiki S....Narimatsu H. (1999)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. (PubMed id 14534330)1, 2 Dunn C.A.... Mager D.L. (2003)
  4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
  5. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)1, 2 Amado M.... Clausen H. (1999)
  6. Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme. (PubMed id 10406968)1, 2 Zhou D.... Hennet T. (1999)
  7. DNA methylation and histone modifications modulate the b1,3 galactosyltransferase b3Gal-T5 native promoter in cancer cells. (PubMed id 22001559)1 Caretti A....Trinchera M. (2012)
  8. Functional analysis and identification of cis-regulat ory elements of human chromosome 21 gene promoters. (PubMed id 20494980)1 Warnatz H.J....Yaspo M.L. (2010)
  9. Genetic utility of broadly defined bipolar schizoaffe ctive disorder as a diagnostic concept. (PubMed id 19567891)1 Hamshere M.L....McGuffin P. (2009)
  10. Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains o n lactosylceramides of selected human colonic carcinoma cell lines. (PubMed id 19136585)1 Lin C.H....Khoo K.H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10317 HGNC: 920 AceView: B3GALT5 Ensembl:ENSG00000183778 euGenes: HUgn10317
ECgene: B3GALT5 Kegg: 10317 H-InvDB: B3GALT5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for B3GALT5 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for B3GALT5 Genetics and Cytogenetics in Oncology and Haematology
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT5
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_432

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for B3GALT5 gene:
Search GeneIP for patents involving B3GALT5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
 Browse OriGene Antibodies   OriGene shRNA RFP for B3GALT5  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for B3GALT5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for B3GALT5  
 OriGene Protein Over-expression Lysate for B3GALT5   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for B3GALT5   Browse 3'-UTR reporter clones for miRNA target validation  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for B3GALT5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for B3GALT5  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 OriGene Purified Protein for B3GALT5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for B3GALT5   OriGene Custom Protein Services for B3GALT5  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat B3GALT5
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing B3GALT5
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B3GALT5
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B3GALT5
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B3GALT5
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B3GALT5
 GenScript Custom Purified and Recombinant Proteins Services for B3GALT5 GenScript cDNA clones with any tag delivered in your preferred vector for B3GALT5
 GenScript Custom Assay Services for B3GALT5 GenScript Custom Superior Antibodies Services for B3GALT5
 GenScript Custom overexpressing Cell Line Services for B3GALT5 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in B3GALT5 promoter
 Search Chromatin IP Primers for B3GALT5
 RT2 qPCR Primer Assay in human, mouse, rat B3GALT5
 Search GNC Networks for B3GALT5
 SABiosciences Custom PCR Arrays for B3GALT5
 Search Tocris compounds for B3GALT5
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 B3GALT5 antibodies
 B3GALT5 proteins
 B3GALT5 lysates
 Search for Antibodies for B3GALT5 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for B3GALT5
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
 Search LifeMap BioReagents cell lines for B3GALT5
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT5
 SwitchGear 3'UTR luciferase reporter plasmids for B3GALT5
 SwitchGear Promoter luciferase reporter plasmids for B3GALT5
 ThermoFisher Antibodies for B3GALT5
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GALT5
 inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for B3GALT5
Sirion Biotech Customized:
 stable knockdown cell line services for B3GALT5
 inducible knockdown cell line services for B3GALT5
 design and validation of potent shRNA sequences against B3GALT5
 adenovirus for potent knockdown of B3GALT5
 adenovirus for overexpression of B3GALT5
 stable overexpressing cell line services for B3GALT5
 inducible overexpressing cell line services for B3GALT5
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      B3GALT5 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4