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B3GALT5 Gene

protein-coding   GIFtS: 54
GCID: GC21P040928

UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 51 2     Beta-1,3-Galactosyltransferase 52
Homolog Of C. Elegans Bt Toxin Resistance Gene Bre-51 2     beta-3-Gx-T52
Beta-1,3-GalTase 52 3     Beta-3-Galactosyltransferase 52
UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 52 3     beta3Gal-T52
GLCT52 5     Beta-3-Gx-T53
3-Galactosyltransferase 51     Beta3Gal-T53
GlcNAc-beta-11     Beta3GalT53
GlcNAc-Beta-1,3-Galactosyltransferase 511     EC 2.4.1.-3
B3GalT-V2     b3Gal-T53
B3GalTx2     UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 53
B3T52     EC 2.4.18

External Ids:    HGNC: 9201   Entrez Gene: 103172   Ensembl: ENSG000001837787   OMIM: 6040665   UniProtKB: Q9Y2C33   

Export aliases for B3GALT5 gene to outside databases

Previous GC identifers: GC21P037603 GC21P039950 GC21P039949 GC21P039951 GC21P026498


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for B3GALT5 Gene:
This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1
Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript
variants have been observed for this gene, but the full-length nature of some of these variants has not been
determined. (provided by RefSeq, Jul 2013)

GeneCards Summary for B3GALT5 Gene:
B3GALT5 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5) is a protein-coding gene. Diseases associated with B3GALT5 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GNT3.

UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
Function: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan
GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor

Gene Wiki entry for B3GALT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Regulatory transcription factor binding sites in the B3GALT5 gene promoter:
         Max1   RP58   p53   Lmo2   FOXL1   RORalpha1   SRY   Sox9   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GALT5 promoter sequence

   Search Chromatin IP Primers for B3GALT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B3GALT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
B3GALT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GALT5 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040928:   GeneLoc Nature:405,311-319
Start:
40,928,369 bp from pter       26,602,223 bp from centromere
End:
41,045,064 bp from pter 26,607,784 bp from centromere
Size:
116,696 bases 5,562 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB020337
genomic clones: P70I24


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3 (See protein sequence)
Recommended Name: Beta-1,3-galactosyltransferase 5  
Size: 310 amino acids; 36189 Da
Secondary accessions: A8KA86 D3DSI3 Q2M3L5 Q53Z19 Q9NY96 Q9P1X6 Q9P1X7

Explore the universe of human proteins at neXtProt for B3GALT5: NX_Q9Y2C3

Explore proteomics data for B3GALT5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn130, Asn174, Asn231
  • Selected DME Specific Peptides for B3GALT5 (Q9Y2C3) (see all 8)
     VMKTDSD  TTRFFTG  FCSGTGY  AIRQTWG 


    See B3GALT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265579.1  NP_006048.1  NP_149360.1  NP_149361.1  NP_149362.2  

    ENSEMBL proteins: 
     ENSP00000369994   ENSP00000369992   ENSP00000343318   ENSP00000381699  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases

    1 InterPro protein domain:
     IPR002659 Glyco_trans_31

    Graphical View of Domain Structure for InterPro Entry Q9Y2C3

    ProtoNet protein and cluster: Q9Y2C3

    1 Blocks protein domain: IPB002659 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
    Similarity: Belongs to the glycosyltransferase 31 family


    B3GALT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3GT5_HUMAN, Q9Y2C3
    Function: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan
    GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor

         Genatlas biochemistry entry for B3GALT5:
    UDP galactose

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity ----
    GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS10212226
         
    B3GALT5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for B3galt5):
     normal 

    B3GALT5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B3GALT5
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    SwitchGear 3'UTR luciferase reporter plasmidB3GALT5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B3GT5_HUMAN, Q9Y2C3: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    extracellular3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005783endoplasmic reticulum IDA16780588
    GO:0005794Golgi apparatus IDA16780588
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    B3GALT5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for B3GALT5 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series
    3Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - globo series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    3 Kegg Pathways  (Kegg details for B3GALT5):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - globo series
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
    Pathway: Protein modification; protein glycosylation


    B3GALT5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for B3GALT5
    Interactions:

        Search GeneGlobe Interaction Network for B3GALT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for B3GALT5 (ENSP000003433184) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALNT1ENSP000003234794STRING: ENSP00000323479
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    FUT1ENSP000003120214STRING: ENSP00000312021
    FUT2ENSP000003757484STRING: ENSP00000375748
    FUT3ENSP000003056034STRING: ENSP00000305603
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--

    B3GALT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for B3GALT5 (B3GT5)

    Selected HMDB Compounds for B3GALT5 (see all 519)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for B3GALT5 gene (6 alternative transcripts): 
    NM_001278650.1  NM_006057.2  NM_033170.2  NM_033171.2  NM_033172.2  NM_033173.1  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380620(uc002yyf.1 uc002yyg.1 uc002yyh.1 uc002yyb.1)
    ENST00000475838 ENST00000380618(uc002yyi.1 uc002yyj.1 uc002yyk.1 uc002yyl.1 uc002yym.1)
    ENST00000343118(uc010gom.1 uc002yye.2) ENST00000398714
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    hsa-miR-4291 hsa-miR-4303 hsa-miR-3155 hsa-miR-24 hsa-miR-3155b hsa-miR-484
    SwitchGear 3'UTR luciferase reporter plasmidB3GALT5 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat B3GALT5

    14 AceView cDNA sequences:

    NM_006057 AB020337 AY372061 NM_033171 NM_033172 NM_033173 NM_033170 AW136254 
    AI739518 BM715577 BM674032 BX281941 BF366265 AU100432 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    B3GALT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    B3GALT5 Expression
    About this image


    B3GALT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
    B3GALT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    B3GALT5 Protein Expression

    UniProtKB/Swiss-Prot: B3GT5_HUMAN, Q9Y2C3
    Tissue specificity: Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal
    and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for B3GALT5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B3galt51 , 5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more1, 5 74.27(n)1
    72.31(a)1
      16 (56.88 cM)5
    939611  NM_033149.31  NP_149161.11 
     962358015 
    chicken
    (Gallus gallus)
    Aves B3GALT51 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more 61.87(n)
    58.9(a)
      427985  XM_004934555.1  XP_004934612.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    57(a)
    51(a)
    1 ↔ many
    1 ↔ many
    3(139533493-139537071)
    3(139511258-139513486)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162522 Xenopus laevis transcribed sequence with weak similarity more 74.38(n)    BJ632719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR759791.26
    Uncharacterized protein
    30(a)
    many ↔ many
    22(27129079-27131561) ENSDARG00000088591
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86683
    CG86731
    UDP-galactose beta-N-acetylglucosamine
    beta-1,3-galactosyltransferase3
    CG86731
    35(a)
    (best of 2)3
    49.78(n)1
    40.97(a)1
      28E73
    341051  NM_135338.21  NP_609182.11 
    rice
    (Oryza sativa)
    Liliopsida Os02g05773001 Os02g0577300 41.28(n)
    31.06(a)
      4329760  NM_001053755.2  NP_001047220.2 


    ENSEMBL Gene Tree for B3GALT5 (if available)
    TreeFam Gene Tree for B3GALT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for B3GALT5 gene
    B3GNT32  B3GNT22  B3GNT52  B3GALT12  B3GNT42  B3GALT42  B3GALT22  B3GNT72  
    B3GNT82  B3GNT62  B3GALNT12  B3GNT92  
    9 SIMAP similar genes for B3GALT5 using alignment to 1 protein entry:     B3GT5_HUMAN:
    OK/KNS-cl.1    B3GALT2    B3GALNT1    B3GALT1    B3GNT5    B3GNT3
    B3GNT6    B3GNT8    B3GNT7

    B3GALT5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for B3GALT5 (see all 227)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860172121,2
    --41027441(+) TTCTTA/CATTAC 4 -- us2k10--------
    rs1468701541,2
    --41027505(+) TTGAGC/GCCAGG 4 -- us2k10--------
    rs22393851,2
    C,F,A,H--41027747(+) GACACA/GGGAGT 4 -- us2k136Minor allele frequency- G:0.45EA NS NA WA CSA 4639
    rs22393861,2
    C,F,A,H--41027823(+) CCTTCT/CCCAGG 4 -- us2k110Minor allele frequency- C:0.44EA NA WA CSA 1878
    rs110884911,2
    C,F,A,H--41027854(+) GTACAA/GCGAAT 4 -- us2k111Minor allele frequency- G:0.10EA NA 618
    rs169980871,2
    C,F--41027864(+) TCCACT/GGAAAT 4 -- us2k18Minor allele frequency- G:0.11NA WA CSA 267
    rs1407043921,2
    --41027902(+) CTTCGA/GCCTTG 4 -- us2k10--------
    rs1445429391,2
    --41028079(+) CAAGCC/TTCCCG 4 -- us2k10--------
    rs762272641,2
    C,F--41028141(+) AGGGAC/TGTTGA 4 -- us2k11Minor allele frequency- T:0.01NA 120
    rs6314301,2
    C,F,O,A,H--41028197(+) GGCCTA/GTGCGG 4 -- us2k130Minor allele frequency- G:0.27NS EA NA WA CSA 2739

    HapMap Linkage Disequilibrium report for B3GALT5 (40928369 - 41045064 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for B3GALT5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing B3GALT5
    DNA2.0 Custom Variant and Variant Library Synthesis for B3GALT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604066    OMIM disorders: --

    7 diseases for B3GALT5:    
    About MalaCards
    pancreatic cancer    pancreatitis    schizoaffective disorder    sjogren's syndrome
    colon adenocarcinoma    hiv-1    adenocarcinoma


    B3GALT5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): B3GALT5
    Human Genome Epidemiology (HuGE) Navigator: B3GALT5 (1 document)

    Export disorders for B3GALT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for B3GALT5 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with B3GALT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and characterization of a novel UDP- galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. (PubMed id 10212226)1, 2, 3, 9 Isshiki S....Narimatsu H. (J. Biol. Chem. 1999)
    2. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. (PubMed id 19567891)1, 4 Hamshere M.L....Craddock N. (Br J Psychiatry 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. (PubMed id 14534330)1, 2 Dunn C.A.... Mager D.L. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    6. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)1, 2 Amado M.... Clausen H. (Biochim. Biophys. Acta 1999)
    7. Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme. (PubMed id 10406968)1, 2 Zhou D.... Hennet T. (Eur. J. Biochem. 1999)
    8. Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. (PubMed id 12855703)1, 9 Isshiki S....Narimatsu H. (J. Biol. Chem. 2003)
    9. Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements. (PubMed id 24128890)1 Zulueta A....Trinchera M. (FASEB J. 2014)
    10. Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients. (PubMed id 22101162)1 Castro I....GonzA!lez M.J. (Rheumatology (Oxford) 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10317 HGNC: 920 AceView: B3GALT5 Ensembl:ENSG00000183778 euGenes: HUgn10317
    ECgene: B3GALT5 Kegg: 10317 H-InvDB: B3GALT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for B3GALT5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for B3GALT5 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_432

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for B3GALT5 gene:
    Search GeneIP for patents involving B3GALT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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