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Aliases for B3GALT5 Gene

Aliases for B3GALT5 Gene

  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 5 2 3
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 5 3 4
  • Homolog Of C. Elegans Bt Toxin Resistance Gene Bre-5 2 3
  • Beta-1,3-GalTase 5 3 4
  • Beta-3-Gx-T5 3 4
  • Beta3Gal-T5 3 4
  • GLCT5 3 6
  • UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 5 4
  • GlcNAc-Beta-1,3-Galactosyltransferase 5 2
  • Beta-1,3-Galactosyltransferase 5 3
  • Beta-3-Galactosyltransferase 5 3
  • Beta3GalT5 4
  • EC 2.4.1.- 4
  • B3GalT-V 3
  • B3Gal-T5 4
  • EC 2.4.1 63
  • B3GalTx 3
  • B3T5 3

External Ids for B3GALT5 Gene

Previous GeneCards Identifiers for B3GALT5 Gene

  • GC21P037603
  • GC21P039950
  • GC21P039949
  • GC21P039951
  • GC21P040928
  • GC21P026498

Summaries for B3GALT5 Gene

Entrez Gene Summary for B3GALT5 Gene

  • This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants have been observed for this gene, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2013]

GeneCards Summary for B3GALT5 Gene

B3GALT5 (UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 5) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GALT5 Gene

  • Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor

Gene Wiki entry for B3GALT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GALT5 Gene

Genomics for B3GALT5 Gene

Regulatory Elements for B3GALT5 Gene

Genomic Location for B3GALT5 Gene

39,556,442 bp from pter
39,673,137 bp from pter
116,696 bases
Plus strand

Genomic View for B3GALT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GALT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GALT5 Gene

Proteins for B3GALT5 Gene

  • Protein details for B3GALT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-1,3-galactosyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • A8KA86
    • D3DSI3
    • Q2M3L5
    • Q53Z19
    • Q9NY96
    • Q9P1X6
    • Q9P1X7

    Protein attributes for B3GALT5 Gene

    310 amino acids
    Molecular mass:
    36189 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GALT5 Gene

Proteomics data for B3GALT5 Gene at MOPED

Selected DME Specific Peptides for B3GALT5 Gene

Post-translational modifications for B3GALT5 Gene

  • Glycosylation at Asn130, Asn174, and Asn231
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for B3GALT5 Gene

Gene Families for B3GALT5 Gene

  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GALT5 Gene

Suggested Antigen Peptide Sequences for B3GALT5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2C3
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GALT5: view

Function for B3GALT5 Gene

Molecular function for B3GALT5 Gene

GENATLAS Biochemistry: UDP galactose
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor

Enzyme Numbers (IUBMB) for B3GALT5 Gene

Gene Ontology (GO) - Molecular Function for B3GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS 10212226
genes like me logo Genes that share ontologies with B3GALT5: view

Phenotypes for B3GALT5 Gene

MGI mutant phenotypes for B3GALT5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with B3GALT5: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for B3GALT5 Gene

Localization for B3GALT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GALT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for B3GALT5 Gene COMPARTMENTS Subcellular localization image for B3GALT5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for B3GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA 16780588
GO:0005794 Golgi apparatus IDA 16780588
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GALT5: view

Pathways for B3GALT5 Gene

genes like me logo Genes that share pathways with B3GALT5: view

UniProtKB/Swiss-Prot Q9Y2C3-B3GT5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GALT5 Gene

Gene Ontology (GO) - Biological Process for B3GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with B3GALT5: view

Compounds for B3GALT5 Gene

(519) HMDB Compounds for B3GALT5 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Hydroxy-2-amino-3-oxo-octadecane
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
genes like me logo Genes that share compounds with B3GALT5: view

Transcripts for B3GALT5 Gene

Unigene Clusters for B3GALT5 Gene

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GALT5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for B3GALT5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GALT5 Gene

No ASD Table

Relevant External Links for B3GALT5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B3GALT5 Gene

mRNA expression in normal human tissues for B3GALT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GALT5 Gene

This gene is overexpressed in Colon - Transverse (15.7) and Small Intestine - Terminal Ileum (10.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for B3GALT5 Gene

SOURCE GeneReport for Unigene cluster for B3GALT5 Gene Hs.733638

mRNA Expression by UniProt/SwissProt for B3GALT5 Gene

Tissue specificity: Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes
genes like me logo Genes that share expressions with B3GALT5: view

In Situ Assay Products

Orthologs for B3GALT5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for B3GALT5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia B3GALT5 35
  • 98.41 (n)
  • 97.45 (a)
B3GALT5 36
  • 97 (a)
(Bos Taurus)
Mammalia B3GALT5 35
  • 75.65 (n)
  • 67.86 (a)
B3GALT5 36
  • 67 (a)
(Canis familiaris)
Mammalia B3GALT5 35
  • 78.17 (n)
  • 76.77 (a)
B3GALT5 36
  • 74 (a)
(Mus musculus)
Mammalia B3galt5 35
  • 74.27 (n)
  • 72.31 (a)
B3galt5 16
B3galt5 36
  • 72 (a)
(Monodelphis domestica)
Mammalia B3GALT5 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia B3GALT5 36
  • 58 (a)
(Rattus norvegicus)
Mammalia B3galt5 35
  • 75.35 (n)
  • 71.66 (a)
(Gallus gallus)
Aves B3GALT5 35
  • 61.87 (n)
  • 58.9 (a)
B3GALT5 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
-- 36
  • 57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16252 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495133 35
  • 60.42 (n)
  • 56.64 (a)
(Danio rerio)
Actinopterygii CR759791.2 36
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8673 35
  • 49.78 (n)
  • 40.97 (a)
brn 37
  • 33 (a)
CG8668 37
  • 35 (a)
(Oryza sativa)
Liliopsida Os02g0577300 35
  • 41.28 (n)
  • 31.06 (a)
Species with no ortholog for B3GALT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GALT5 Gene

Gene Tree for B3GALT5 (if available)
Gene Tree for B3GALT5 (if available)

Paralogs for B3GALT5 Gene

Selected SIMAP similar genes for B3GALT5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GALT5: view

Variants for B3GALT5 Gene

Sequence variations from dbSNP and Humsavar for B3GALT5 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs83969 -- 39,636,570(-) CAGGA(C/G)CCTGT intron-variant
rs117482 -- 39,631,456(-) gtagg(C/G)tgggc intron-variant
rs398644 -- 39,626,252(-) aaatt(C/T)tgtca intron-variant
rs426768 -- 39,626,083(-) gagga(A/G)aaatg intron-variant
rs429096 -- 39,627,301(-) CCAAA(G/T)TCTGC intron-variant

Relevant External Links for B3GALT5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for B3GALT5 Gene

Disorders for B3GALT5 Gene

Relevant External Links for B3GALT5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with B3GALT5: view

No data available for UniProtKB/Swiss-Prot for B3GALT5 Gene

Publications for B3GALT5 Gene

  1. Cloning, expression, and characterization of a novel UDP- galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. (PMID: 10212226) Isshiki S. … Narimatsu H. (J. Biol. Chem. 1999) 2 3 4 23
  2. An endogenous retroviral long terminal repeat is the dominant promoter for human beta1,3-galactosyltransferase 5 in the colon. (PMID: 14534330) Dunn C.A. … Mager D.L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. (PMID: 19567891) Hamshere M.L. … Craddock N. (Br J Psychiatry 2009) 3 48
  4. Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. (PMID: 12855703) Isshiki S. … Narimatsu H. (J. Biol. Chem. 2003) 3 23
  5. Molecular cloning of a human UDP-galactose:GlcNAcbeta1,3GalNAc beta1, 3 galactosyltransferase gene encoding an O-linked core3-elongation enzyme. (PMID: 10406968) Zhou D. … Hennet T. (Eur. J. Biochem. 1999) 3 4

Products for B3GALT5 Gene

Sources for B3GALT5 Gene

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