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Aliases for B3GALT5 Gene

Aliases for B3GALT5 Gene

  • Beta-1,3-Galactosyltransferase 5 2 3 5
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 5 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 5 2 3
  • Homolog Of C. Elegans Bt Toxin Resistance Gene Bre-5 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase 5 2 3
  • Beta-1,3-GalTase 5 3 4
  • Beta-3-Gx-T5 3 4
  • Beta3Gal-T5 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 5 4
  • GlcNAc-Beta-1,3-Galactosyltransferase 5 2
  • Beta-3-Galactosyltransferase 5 3
  • Beta3GalT5 4
  • EC 2.4.1.- 4
  • B3GalT-V 3
  • B3Gal-T5 4
  • EC 2.4.1 63
  • B3GalTx 3
  • GLCT5 3
  • B3T5 3

External Ids for B3GALT5 Gene

Previous GeneCards Identifiers for B3GALT5 Gene

  • GC21P037603
  • GC21P039950
  • GC21P039949
  • GC21P039951
  • GC21P040928
  • GC21P026498

Summaries for B3GALT5 Gene

Entrez Gene Summary for B3GALT5 Gene

  • This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants have been observed for this gene, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2013]

GeneCards Summary for B3GALT5 Gene

B3GALT5 (Beta-1,3-Galactosyltransferase 5) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - globo series and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include galactosyltransferase activity and UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GALT5 Gene

  • Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

Gene Wiki entry for B3GALT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GALT5 Gene

Genomics for B3GALT5 Gene

Regulatory Elements for B3GALT5 Gene

Enhancers for B3GALT5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B3GALT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GALT5 Gene

Chromosome:
21
Start:
39,556,442 bp from pter
End:
39,673,137 bp from pter
Size:
116,696 bases
Orientation:
Plus strand

Genomic View for B3GALT5 Gene

Genes around B3GALT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GALT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GALT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GALT5 Gene

Proteins for B3GALT5 Gene

  • Protein details for B3GALT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C3-B3GT5_HUMAN
    Recommended name:
    Beta-1,3-galactosyltransferase 5
    Protein Accession:
    Q9Y2C3
    Secondary Accessions:
    • A8KA86
    • D3DSI3
    • Q2M3L5
    • Q53Z19
    • Q9NY96
    • Q9P1X6
    • Q9P1X7

    Protein attributes for B3GALT5 Gene

    Size:
    310 amino acids
    Molecular mass:
    36189 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GALT5 Gene

Proteomics data for B3GALT5 Gene at MOPED

Selected DME Specific Peptides for B3GALT5 Gene

Post-translational modifications for B3GALT5 Gene

  • Glycosylation at Asn 130, Asn 174, and Asn 231
  • Modification sites at PhosphoSitePlus

Domains & Families for B3GALT5 Gene

Gene Families for B3GALT5 Gene

Protein Domains for B3GALT5 Gene

Suggested Antigen Peptide Sequences for B3GALT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2C3

UniProtKB/Swiss-Prot:

B3GT5_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GALT5: view

Function for B3GALT5 Gene

Molecular function for B3GALT5 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

Enzyme Numbers (IUBMB) for B3GALT5 Gene

Phenotypes for B3GALT5 Gene

genes like me logo Genes that share phenotypes with B3GALT5: view

Animal Models for B3GALT5 Gene

MGI Knock Outs for B3GALT5:

Animal Model Products

miRNA for B3GALT5 Gene

miRTarBase miRNAs that target B3GALT5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GALT5 Gene

Localization for B3GALT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GALT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GALT5 Gene COMPARTMENTS Subcellular localization image for B3GALT5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for B3GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GALT5: view

Pathways & Interactions for B3GALT5 Gene

genes like me logo Genes that share pathways with B3GALT5: view

UniProtKB/Swiss-Prot Q9Y2C3-B3GT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GALT5 Gene

Gene Ontology (GO) - Biological Process for B3GALT5 Gene

None

No data available for SIGNOR curated interactions for B3GALT5 Gene

Drugs & Compounds for B3GALT5 Gene

(3) Drugs for B3GALT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(462) Additional Compounds for B3GALT5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with B3GALT5: view

Transcripts for B3GALT5 Gene

Unigene Clusters for B3GALT5 Gene

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GALT5 Gene

No ASD Table

Relevant External Links for B3GALT5 Gene

GeneLoc Exon Structure for
B3GALT5
ECgene alternative splicing isoforms for
B3GALT5

Expression for B3GALT5 Gene

mRNA expression in normal human tissues for B3GALT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GALT5 Gene

This gene is overexpressed in Colon - Transverse (x15.7) and Small Intestine - Terminal Ileum (x10.1).

Protein differential expression in normal tissues from HIPED for B3GALT5 Gene

This gene is overexpressed in Heart (47.9) and Colon (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for B3GALT5 Gene



SOURCE GeneReport for Unigene cluster for B3GALT5 Gene Hs.733638

mRNA Expression by UniProt/SwissProt for B3GALT5 Gene

Q9Y2C3-B3GT5_HUMAN
Tissue specificity: Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with B3GALT5: view

Protein tissue co-expression partners for B3GALT5 Gene

Primer Products

In Situ Assay Products

Orthologs for B3GALT5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for B3GALT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GALT5 35
  • 75.65 (n)
  • 67.86 (a)
B3GALT5 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GALT5 35
  • 78.17 (n)
  • 76.77 (a)
B3GALT5 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3galt5 35
  • 74.27 (n)
  • 72.31 (a)
B3galt5 16
B3galt5 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B3GALT5 35
  • 98.41 (n)
  • 97.45 (a)
B3GALT5 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3galt5 35
  • 75.35 (n)
  • 71.66 (a)
oppossum
(Monodelphis domestica)
Mammalia B3GALT5 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GALT5 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GALT5 35
  • 61.87 (n)
  • 58.9 (a)
B3GALT5 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495133 35
  • 60.42 (n)
  • 56.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16252 35
zebrafish
(Danio rerio)
Actinopterygii CR759791.2 36
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta brn 37
  • 33 (a)
CG8668 37
  • 35 (a)
CG8673 35
  • 49.78 (n)
  • 40.97 (a)
rice
(Oryza sativa)
Liliopsida Os02g0577300 35
  • 41.28 (n)
  • 31.06 (a)
Species with no ortholog for B3GALT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GALT5 Gene

ENSEMBL:
Gene Tree for B3GALT5 (if available)
TreeFam:
Gene Tree for B3GALT5 (if available)

Paralogs for B3GALT5 Gene

(9) SIMAP similar genes for B3GALT5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GALT5: view

Variants for B3GALT5 Gene

Sequence variations from dbSNP and Humsavar for B3GALT5 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs3746887 - 39,660,813(+) GAGGA(C/T)GGTGA reference, missense
rs734411 - 39,660,990(+) CCATC(A/G)CTTTT reference, missense
rs12627708 - 39,660,640(+) TACAG(G/T)CTAAA reference, missense
rs1205324 -- 39,639,766(-) gcgca(G/T)tggtt intron-variant
rs1205327 -- 39,639,548(-) gagca(A/G)agatc intron-variant

Variation tolerance for B3GALT5 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GALT5 Gene

HapMap Linkage Disequilibrium report
B3GALT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for B3GALT5 Gene

Disorders for B3GALT5 Gene

Relevant External Links for B3GALT5

Genetic Association Database (GAD)
B3GALT5
Human Genome Epidemiology (HuGE) Navigator
B3GALT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GALT5

No disorders were found for B3GALT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GALT5 Gene

Publications for B3GALT5 Gene

  1. Cloning, expression, and characterization of a novel UDP- galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom. (PMID: 10212226) Isshiki S. … Narimatsu H. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. (PMID: 12855703) Isshiki S. … Narimatsu H. (J. Biol. Chem. 2003) 3 23
  3. Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements. (PMID: 24128890) Zulueta A. … Trinchera M. (FASEB J. 2014) 3
  4. DNA methylation and histone modifications modulate the I^1,3 galactosyltransferase I^3Gal-T5 native promoter in cancer cells. (PMID: 22001559) Caretti A. … Trinchera M. (Int. J. Biochem. Cell Biol. 2012) 3
  5. Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients. (PMID: 22101162) Castro I. … GonzA!lez M.J. (Rheumatology (Oxford) 2012) 3

Products for B3GALT5 Gene

Sources for B3GALT5 Gene

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