Free for academic non-profit institutions. Other users need a Commercial license

Aliases for B3GALT4 Gene

Aliases for B3GALT4 Gene

  • Beta-1,3-Galactosyltransferase 4 2 3 5
  • UDP-Galactose:Beta-N-Acetyl-Galactosamine-Beta-1,3-Galactosyltransferase 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 4 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase 4 2 3
  • Ganglioside Galactosyltransferase 3 4
  • Beta-1,3-GalTase 4 3 4
  • EC 2.4.1.62 4 63
  • BETA3GALT4 3 4
  • B3Gal-T4 3 4
  • Gal-T2 3 4
  • GALT4 3 4
  • Beta-3-Galactosyltransferase 4 3
  • Beta3Gal-T4 4
  • GALT2 3

External Ids for B3GALT4 Gene

Previous GeneCards Identifiers for B3GALT4 Gene

  • GC06U990168
  • GC06P033241
  • GC06P033237
  • GC06P033291
  • GC06P033252
  • GC06P033352
  • GC06P033244
  • GC06P032986

Summaries for B3GALT4 Gene

Entrez Gene Summary for B3GALT4 Gene

  • This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GALT4 Gene

B3GALT4 (Beta-1,3-Galactosyltransferase 4) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - ganglio series and Metabolism. GO annotations related to this gene include galactosyltransferase activity and ganglioside galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GALT4 Gene

  • Involved in GM1/GD1B/GA1 ganglioside biosynthesis.

Gene Wiki entry for B3GALT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GALT4 Gene

Genomics for B3GALT4 Gene

Regulatory Elements for B3GALT4 Gene

Enhancers for B3GALT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B3GALT4 on UCSC Golden Path with GeneCards custom track

Promoters for B3GALT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B3GALT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GALT4 Gene

Chromosome:
6
Start:
33,277,132 bp from pter
End:
33,284,832 bp from pter
Size:
7,701 bases
Orientation:
Plus strand

Genomic View for B3GALT4 Gene

Genes around B3GALT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GALT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GALT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for B3GALT4 Gene

  • Protein details for B3GALT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96024-B3GT4_HUMAN
    Recommended name:
    Beta-1,3-galactosyltransferase 4
    Protein Accession:
    O96024

    Protein attributes for B3GALT4 Gene

    Size:
    378 amino acids
    Molecular mass:
    41537 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GALT4 Gene

Proteomics data for B3GALT4 Gene at MOPED

Selected DME Specific Peptides for B3GALT4 Gene

Post-translational modifications for B3GALT4 Gene

  • Glycosylation at Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GALT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for B3GALT4 Gene

Gene Families for B3GALT4 Gene

Protein Domains for B3GALT4 Gene

Graphical View of Domain Structure for InterPro Entry

O96024

UniProtKB/Swiss-Prot:

B3GT4_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GALT4: view

Function for B3GALT4 Gene

Molecular function for B3GALT4 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Involved in GM1/GD1B/GA1 ganglioside biosynthesis.

Enzyme Numbers (IUBMB) for B3GALT4 Gene

genes like me logo Genes that share phenotypes with B3GALT4: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for B3GALT4 Gene

Localization for B3GALT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GALT4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GALT4 Gene COMPARTMENTS Subcellular localization image for B3GALT4 gene
Compartment Confidence
golgi apparatus 3

No data available for Gene Ontology (GO) - Cellular Components for B3GALT4 Gene

Pathways & Interactions for B3GALT4 Gene

genes like me logo Genes that share pathways with B3GALT4: view

Pathways by source for B3GALT4 Gene

UniProtKB/Swiss-Prot O96024-B3GT4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GALT4 Gene

Selected Interacting proteins: O96024-B3GT4_HUMAN for B3GALT4 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for B3GALT4 Gene

None

No data available for SIGNOR curated interactions for B3GALT4 Gene

Drugs & Compounds for B3GALT4 Gene

(3) Drugs for B3GALT4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(62) Additional Compounds for B3GALT4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (d18:0/12:0)
Ganglioside GM1 (d18:0/14:0)
genes like me logo Genes that share compounds with B3GALT4: view

Transcripts for B3GALT4 Gene

mRNA/cDNA for B3GALT4 Gene

Unigene Clusters for B3GALT4 Gene

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GALT4 Gene

No ASD Table

Relevant External Links for B3GALT4 Gene

GeneLoc Exon Structure for
B3GALT4
ECgene alternative splicing isoforms for
B3GALT4

Expression for B3GALT4 Gene

mRNA expression in normal human tissues for B3GALT4 Gene

mRNA differential expression in normal tissues according to GTEx for B3GALT4 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for B3GALT4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for B3GALT4 Gene



SOURCE GeneReport for Unigene cluster for B3GALT4 Gene Hs.534375

mRNA Expression by UniProt/SwissProt for B3GALT4 Gene

O96024-B3GT4_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung.
genes like me logo Genes that share expression patterns with B3GALT4: view

Protein tissue co-expression partners for B3GALT4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for B3GALT4 Gene

Orthologs for B3GALT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for B3GALT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GALT4 35
  • 83.29 (n)
  • 83.65 (a)
B3GALT4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GALT4 35
  • 83.52 (n)
  • 83.15 (a)
B3GALT4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3galt4 35
  • 80.25 (n)
  • 82.05 (a)
B3galt4 16
B3galt4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B3GALT4 35
  • 99.82 (n)
  • 100 (a)
B3GALT4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3galt4 35
  • 79.58 (n)
  • 82.62 (a)
oppossum
(Monodelphis domestica)
Mammalia B3GALT4 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GALT4 36
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GALT4 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia b3galt4 35
  • 49.03 (n)
  • 45.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4552 35
zebrafish
(Danio rerio)
Actinopterygii LOC101886595 35
  • 48.75 (n)
  • 46.24 (a)
rps18 35
B3GALT4 36
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.25487 35
corn
(Zea mays)
Liliopsida Zm.7097 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5482 35
Species with no ortholog for B3GALT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GALT4 Gene

ENSEMBL:
Gene Tree for B3GALT4 (if available)
TreeFam:
Gene Tree for B3GALT4 (if available)

Paralogs for B3GALT4 Gene

(1) SIMAP similar genes for B3GALT4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with B3GALT4: view

Variants for B3GALT4 Gene

Sequence variations from dbSNP and Humsavar for B3GALT4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2231259 -- 33,277,578(+) GCCCT(G/T)CCCCG reference, synonymous-codon
rs2231260 -- 33,278,140(+) CACCG(C/G/T)GGGGC reference, missense
rs2231261 -- 33,278,415(+) TCCCA(C/T)AGGCT reference, synonymous-codon
rs62639320 -- 33,277,576(+) TGGCC(C/G)TGCCC reference, missense
rs72654485 -- 33,277,005(+) GCTGG(A/G/T)CAGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for B3GALT4 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897

Variation tolerance for B3GALT4 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GALT4 Gene

HapMap Linkage Disequilibrium report
B3GALT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GALT4 Gene

Disorders for B3GALT4 Gene

Relevant External Links for B3GALT4

Genetic Association Database (GAD)
B3GALT4
Human Genome Epidemiology (HuGE) Navigator
B3GALT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GALT4

No disorders were found for B3GALT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GALT4 Gene

Publications for B3GALT4 Gene

  1. A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta- nacetyl-galactosamine beta-1,3-galactosyltransferase family. (PMID: 9582303) Amado M. … Clausen H. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function. (PMID: 21519903) Dong L. … Ladisch S. (Glycoconj. J. 2011) 3
  5. GM1a88/a88GD1ba88/a88GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. (PMID: 20594196) Dong Y. … Furukawa K. (Cancer Sci. 2010) 3

Products for B3GALT4 Gene

Sources for B3GALT4 Gene

Content