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Aliases for B3GALT4 Gene

Aliases for B3GALT4 Gene

  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 4 2 3
  • UDP-Galactose:Beta-N-Acetyl-Galactosamine-Beta-1,3-Galactosyltransferase 3 4
  • Ganglioside Galactosyltransferase 3 4
  • Beta-1,3-GalTase 4 3 4
  • EC 2.4.1.62 4 63
  • BETA3GALT4 3 4
  • B3Gal-T4 3 4
  • Gal-T2 3 4
  • GALT4 3 4
  • Beta-1,3-Galactosyltransferase 4 3
  • Beta-3-Galactosyltransferase 4 3
  • Beta3Gal-T4 4
  • GALT2 3

External Ids for B3GALT4 Gene

Previous GeneCards Identifiers for B3GALT4 Gene

  • GC06U990168
  • GC06P033241
  • GC06P033237
  • GC06P033291
  • GC06P033252
  • GC06P033352
  • GC06P033244
  • GC06P032986

Summaries for B3GALT4 Gene

Entrez Gene Summary for B3GALT4 Gene

  • This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GALT4 Gene

B3GALT4 (UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 4) is a Protein Coding gene. Diseases associated with B3GALT4 include uterine corpus cancer. Among its related pathways are Metabolism and Other types of O-glycan biosynthesis. GO annotations related to this gene include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity and ganglioside galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GALT4 Gene

  • Involved in GM1/GD1B/GA1 ganglioside biosynthesis.

Gene Wiki entry for B3GALT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GALT4 Gene

Genomics for B3GALT4 Gene

Regulatory Elements for B3GALT4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for B3GALT4 Gene

Start:
33,277,132 bp from pter
End:
33,284,832 bp from pter
Size:
7,701 bases
Orientation:
Plus strand

Genomic View for B3GALT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B3GALT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for B3GALT4 Gene

  • Protein details for B3GALT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96024-B3GT4_HUMAN
    Recommended name:
    Beta-1,3-galactosyltransferase 4
    Protein Accession:
    O96024
    Secondary Accessions:

    Protein attributes for B3GALT4 Gene

    Size:
    378 amino acids
    Molecular mass:
    41537 Da
    Quaternary structure:
    No Data Available

neXtProt entry for B3GALT4 Gene

Proteomics data for B3GALT4 Gene at MOPED

Selected DME Specific Peptides for B3GALT4 Gene

Post-translational modifications for B3GALT4 Gene

  • Glycosylation at Asn149
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GALT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for B3GALT4 Gene

Gene Families for B3GALT4 Gene

HGNC:
  • B3GT :Beta 3-glycosyltransferases

Protein Domains for B3GALT4 Gene

Graphical View of Domain Structure for InterPro Entry

O96024

UniProtKB/Swiss-Prot:

B3GT4_HUMAN :
  • O96024
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GALT4: view

Function for B3GALT4 Gene

Molecular function for B3GALT4 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
UniProtKB/Swiss-Prot Function:
Involved in GM1/GD1B/GA1 ganglioside biosynthesis.

Enzyme Numbers (IUBMB) for B3GALT4 Gene

Gene Ontology (GO) - Molecular Function for B3GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity --
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS 9582303
GO:0047915 ganglioside galactosyltransferase activity IEA --
genes like me logo Genes that share ontologies with B3GALT4: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GALT4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for B3GALT4 Gene

Localization for B3GALT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GALT4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GALT4 Gene COMPARTMENTS Subcellular localization image for B3GALT4 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for B3GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with B3GALT4: view

Pathways for B3GALT4 Gene

genes like me logo Genes that share pathways with B3GALT4: view

Pathways by source for B3GALT4 Gene

UniProtKB/Swiss-Prot O96024-B3GT4_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B3GALT4 Gene

Selected Interacting proteins: O96024-B3GT4_HUMAN for B3GALT4 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for B3GALT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with B3GALT4: view

Compounds for B3GALT4 Gene

(62) HMDB Compounds for B3GALT4 Gene

Compound Synonyms Cas Number PubMed IDs
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/22:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1

(11) Novoseek inferred chemical compound relationships for B3GALT4 Gene

Compound -log(P) Hits PubMed IDs
laccer 94.8 9
lactosylceramide 93.4 7
glucosylceramide 88.2 6
glycosphingolipid 86.3 2
ceramide 67.6 2
genes like me logo Genes that share compounds with B3GALT4: view

Transcripts for B3GALT4 Gene

mRNA/cDNA for B3GALT4 Gene

Unigene Clusters for B3GALT4 Gene

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for B3GALT4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for B3GALT4 Gene

No ASD Table

Relevant External Links for B3GALT4 Gene

GeneLoc Exon Structure for
B3GALT4
ECgene alternative splicing isoforms for
B3GALT4

Expression for B3GALT4 Gene

mRNA expression in normal human tissues for B3GALT4 Gene

mRNA differential expression in normal tissues according to GTEx for B3GALT4 Gene

This gene is overexpressed in Whole Blood (5.5).

Protein differential expression in normal tissues for B3GALT4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for B3GALT4 Gene

SOURCE GeneReport for Unigene cluster for B3GALT4 Gene Hs.534375

mRNA Expression by UniProt/SwissProt for B3GALT4 Gene

O96024-B3GT4_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung.
genes like me logo Genes that share expressions with B3GALT4: view

Expression partners for B3GALT4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for B3GALT4 Gene

Orthologs for B3GALT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for B3GALT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B3GALT4 35
  • 83.29 (n)
  • 83.65 (a)
B3GALT4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B3GALT4 35
  • 83.52 (n)
  • 83.15 (a)
B3GALT4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3galt4 35
  • 80.25 (n)
  • 82.05 (a)
B3galt4 16
B3galt4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B3GALT4 35
  • 99.82 (n)
  • 100 (a)
B3GALT4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3galt4 35
  • 79.58 (n)
  • 82.62 (a)
oppossum
(Monodelphis domestica)
Mammalia B3GALT4 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GALT4 36
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves B3GALT4 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia b3galt4 35
  • 49.03 (n)
  • 45.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4552 35
zebrafish
(Danio rerio)
Actinopterygii LOC101886595 35
  • 48.75 (n)
  • 46.24 (a)
rps18 35
B3GALT4 36
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.25487 35
corn
(Zea mays)
Liliopsida Zm.7097 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5482 35
Species with no ortholog for B3GALT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GALT4 Gene

ENSEMBL:
Gene Tree for B3GALT4 (if available)
TreeFam:
Gene Tree for B3GALT4 (if available)

Paralogs for B3GALT4 Gene

Selected SIMAP similar genes for B3GALT4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with B3GALT4: view

Variants for B3GALT4 Gene

Sequence variations from dbSNP and Humsavar for B3GALT4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2231259 -- 33,277,578(+) GCCCT(G/T)CCCCG reference, synonymous-codon
rs2231260 -- 33,278,140(+) CACCG(C/G/T)GGGGC missense, reference
rs34974978 -- 33,277,284(+) CCCCA(-/G)GGTGC utr-variant-5-prime
rs45531637 -- 33,277,559(+) CTCAC(C/T)GGGGC reference, missense
rs61736930 -- 33,278,091(+) CCTCT(A/T)CTGTA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for B3GALT4 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897

Relevant External Links for B3GALT4 Gene

HapMap Linkage Disequilibrium report
B3GALT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B3GALT4 Gene

Disorders for B3GALT4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for B3GALT4 Gene in MalaCards »

(1) Diseases for B3GALT4 Gene including...

(1) University of Copenhagen DISEASES for B3GALT4 Gene

(2) Novoseek inferred disease relationships for B3GALT4 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 35.7 1
tumors 0 2

Relevant External Links for B3GALT4

Genetic Association Database (GAD)
B3GALT4
Human Genome Epidemiology (HuGE) Navigator
B3GALT4
genes like me logo Genes that share disorders with B3GALT4: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for B3GALT4 Gene

Publications for B3GALT4 Gene

  1. A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta- nacetyl-galactosamine beta-1,3-galactosyltransferase family. (PMID: 9582303) Amado M. … Clausen H. (J. Biol. Chem. 1998) 2 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The beta 1,3-galactosyltransferase-4 (b3Gal-T4) gene is located in the centromeric segment of the human MHC class II region. (PMID: 10663566) Shiina T. … Inoko H. (Immunogenetics 2000) 3 4
  5. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PMID: 18193043) Willer C.J. … Abecasis G.R. (Nat. Genet. 2008) 3 48

Products for B3GALT4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate B3GALT4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for B3GALT4
    • Block miRNA regulation of B3GALT4 using miScript Target Protectors

    Sources for B3GALT4 Gene

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