Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



B3GALT4 Gene

protein-coding   GIFtS: 57
GCID: GC06P033244

UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide...

  See B3GALT4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 41 2     GALT22
Beta-1,3-GalTase 42 3     Beta-1,3-Galactosyltransferase 42
Ganglioside Galactosyltransferase2 3     Beta-3-Galactosyltransferase 42
GALT42 3     gal-T22
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase2 3     Beta3Gal-T43
b3Gal-T42 3     Beta3GalT43
EC 2.4.1.623 8     Gal-T23
BETA3GALT42     GalT43

External Ids:    HGNC: 9191   Entrez Gene: 87052   Ensembl: ENSG000002358637   OMIM: 6030955   UniProtKB: O960243   

Export aliases for B3GALT4 gene to outside databases

Previous GC identifers: GC06U990168 GC06P033241 GC06P033237 GC06P033291 GC06P033252 GC06P033352 GC06P032986


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for B3GALT4 Gene:
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II
membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and
UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine).
The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence
contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or
alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas
beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during
embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other
beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to
the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid
biosynthesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for B3GALT4 Gene:
B3GALT4 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4) is a protein-coding gene. Diseases associated with B3GALT4 include uterine corpus cancer. GO annotations related to this gene include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity and ganglioside galactosyltransferase activity. An important paralog of this gene is B3GNT3.

UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024
Function: Involved in GM1/GD1B/GA1 ganglioside biosynthesis

Gene Wiki entry for B3GALT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the B3GALT4 gene promoter:
         ER-alpha   TBP   p53   AP-1   Olf-1   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB3GALT4 promoter sequence
   Search Chromatin IP Primers for B3GALT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B3GALT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

B3GALT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B3GALT4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033244:  view genomic region     (about GC identifiers)

Start:
33,244,917 bp from pter      End:
33,252,609 bp from pter
Size:
7,693 bases      Orientation:
plus strand

4 alternative locations:
Chr6+,NT_167248 4,477,156-4,478,841      Chr6+,NT_167245 4,526,239-4,527,924      Chr6+,NT_113891.2 4,688,727-4,690,412     
Chr6+,NT_167247 4,718,691-4,720,376     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024 (See protein sequence)
Recommended Name: Beta-1,3-galactosyltransferase 4  
Size: 378 amino acids; 41537 Da

Explore the universe of human proteins at neXtProt for B3GALT4: NX_O96024

Explore proteomics data for B3GALT4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn149
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for B3GALT4 (O96024) (see all 6)
     NLTLKTL  MQEAWKLV  PLLYLGRVHWRV  GEELLSLSLASL 


    See B3GALT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003773.1  
    ENSEMBL proteins: 
     ENSP00000390784  

    B3GALT4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for B3GALT4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for B3GALT4
    GenScript Custom Purified and Recombinant Proteins Services for B3GALT4
    Novus Biologicals B3GALT4 Proteins
    Novus Biologicals B3GALT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for B3GALT4 

    B3GALT4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for B3GALT4
    OriGene Custom Antibody Services for B3GALT4
    Novus Biologicals B3GALT4 Antibodies
    Abcam antibodies for B3GALT4
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for B3GALT4
    LSBio Antibodies in human, mouse, rat for B3GALT4

    B3GALT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for B3GALT4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for B3GALT4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for B3GALT4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases

    1 InterPro protein domain:
     IPR002659 Glyco_trans_31

    Graphical View of Domain Structure for InterPro Entry O96024

    ProtoNet protein and cluster: O96024

    1 Blocks protein domain: IPB002659 Glycosyl transferase

    UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024
    Similarity: Belongs to the glycosyltransferase 31 family


    Find genes that share domains with B3GALT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B3GT4_HUMAN, O96024
    Function: Involved in GM1/GD1B/GA1 ganglioside biosynthesis
    Catalytic activity: UDP-alpha-D-galactose + an
    N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
    = UDP + a
    beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

         Genatlas biochemistry entry for B3GALT4:
    UDP galactose

         Enzyme Number (IUBMB): EC 2.4.1.621 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity ----
    GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity TAS9582303
    GO:0047915ganglioside galactosyltransferase activity IEA--
         
    Find genes that share ontologies with B3GALT4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B3GALT4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for B3GALT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for B3GALT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for B3GALT4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat B3GALT4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate B3GALT4
    SwitchGear 3'UTR luciferase reporter plasmidB3GALT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for B3GALT4
    Predesigned siRNA for gene silencing in human, mouse, rat B3GALT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for B3GALT4

    Clone
    Products:
         
    OriGene clones in human, mouse for B3GALT4 (see all 6)
    OriGene ORF clones in mouse, rat for B3GALT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: B3GALT4 (NM_003782)
    Sino Biological Human cDNA Clone for B3GALT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GALT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GALT4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for B3GALT4
    Browse ESI BIO Cell Lines and PureStem Progenitors for B3GALT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    B3GT4_HUMAN, O96024: Golgi apparatus membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with B3GALT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for B3GALT4 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycosphingolipid biosynthesis - ganglio series
    Ganglio Sphingolipid Metabolism0.53
    Glycosphingolipid biosynthesis - ganglio series0.53
    2Metabolism
    Metabolic pathways0.38
    3Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis


    Find genes that share SuperPaths with B3GALT4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for B3GALT4
        Ganglio Sphingolipid Metabolism



    3 Kegg Pathways  (Kegg details for B3GALT4):
        Other types of O-glycan biosynthesis
    Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024
    Pathway: Protein modification; protein glycosylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for B3GALT4
    Interactions:

        Search GeneGlobe Interaction Network for B3GALT4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for B3GALT4 (O960242, 3 ENSP000003907844) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNLL1P631672, 3MINT-8249201 I2D: score=2 
    METTL18O955682, 3MINT-8249190 I2D: score=2 
    DDX19BQ9UMR23, ENSP000002880714I2D: score=3 STRING: ENSP00000288071
    --Q7Z4W53I2D: score=1 
    --Q96KE72MINT-65227
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--

    Find genes that share ontologies with B3GALT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for B3GALT4 (B3GT4)

    Selected HMDB Compounds for B3GALT4 (see all 62)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ganglioside GM1 (d18:0/12:0) --12486725
    Ganglioside GM1 (d18:0/14:0) --12486725
    Ganglioside GM1 (d18:0/16:0) --12486725
    Ganglioside GM1 (d18:0/18:0) --12486725
    Ganglioside GM1 (d18:0/18:1(11Z)) --12486725
    Ganglioside GM1 (d18:0/18:1(9Z)) --12486725
    Ganglioside GM1 (d18:0/20:0) --12486725
    Ganglioside GM1 (d18:0/22:0) --12486725
    Ganglioside GM1 (d18:0/22:1(13Z)) --12486725
    Ganglioside GM1 (d18:0/23:0) --12486725

    Selected Novoseek inferred chemical compound relationships for B3GALT4 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laccer 94.8 9 11740154 (2), 15229397 (2), 12900410 (1), 8481397 (1) (see all 7)
    lactosylceramide 93.4 8 8808768 (1), 11740154 (1), 8481397 (1), 9343929 (1) (see all 7)
    glucosylceramide 88.2 10 8808768 (1), 9061365 (1), 11740154 (1), 8781979 (1) (see all 6)
    glycosphingolipid 86.3 3 11740154 (1), 8481397 (1)
    ceramide 67.6 2 11740154 (1), 1834652 (1)
    ganglioside 66.9 6 8536214 (1), 8005614 (1), 9582303 (1)
    udpglucose 65.4 4 9061365 (1), 8781979 (1), 1551920 (1)
    galactose 32.8 1 8005614 (1)
    gtp 29.4 1 9254052 (1)
    lipid 1.29 4 2129343 (2), 15229397 (1)



    Find genes that share compounds with B3GALT4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for B3GALT4 gene: 
    NM_003782.3  

    Unigene Cluster for B3GALT4:

    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
    Hs.534375  [show with all ESTs]
    Unigene Representative Sequence: NM_003782
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606990 ENST00000451237(uc003odr.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat B3GALT4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate B3GALT4
    SwitchGear 3'UTR luciferase reporter plasmidB3GALT4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for B3GALT4
    Predesigned siRNA for gene silencing in human, mouse, rat B3GALT4
    Clone
    Products:
         
    OriGene clones in human, mouse for B3GALT4 (see all 6)
    OriGene ORF clones in mouse, rat for B3GALT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: B3GALT4 (NM_003782)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B3GALT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GALT4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for B3GALT4
    OriGene qSTAR qPCR primer pairs in human, mouse for B3GALT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat B3GALT4
      QuantiTect SYBR Green Assays in human, mouse, rat B3GALT4
      QuantiFast Probe-based Assays in human, mouse, rat B3GALT4

    Additional mRNA sequence: 

    AB026730.1 AF063595.1 AK075312.1 AK315647.1 BC032574.1 CR457093.1 Y15061.1 

    3 DOTS entries:

    DT.92419828  DT.210266  DT.97788718 

    Selected AceView cDNA sequences (see all 2732):

    BQ267768 BM090959 AJ714570 AA335401 BI857212 F24265 BM988608 AA497005 
    BE254292 BM545419 BE783565 AA112566 NM_022551 AV651340 AW338220 BF726352 
    BG026719 BU185555 H56513 BU947365 CB409488 BM782807 BU859886 BG421436 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    B3GALT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCGATACG
    B3GALT4 Expression
    About this image

    B3GALT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    B3GALT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534375

    UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024
    Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain,
    placenta, kidney, liver and lung

        Custom PCR Arrays for B3GALT4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for B3GALT4
    OriGene qSTAR qPCR primer pairs in human, mouse for B3GALT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat B3GALT4
    QuantiTect SYBR Green Assays in human, mouse, rat B3GALT4
    QuantiFast Probe-based Assays in human, mouse, rat B3GALT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for B3GALT4 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B3galt41 , 5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more1, 5 80.25(n)1
    82.05(a)1
      17 (17.98 cM)5
    542181  NM_019420.21  NP_062293.11 
     339499095 
    chicken
    (Gallus gallus)
    Aves B3GALT46
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase,...
    28(a)
    1 ↔ 1
    17(8270068-8272130)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    45(a)
    42(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343964.1(94620-95678)
    GL343520.1(383086-384138)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45522 Xenopus laevis transcribed sequence with strong similarity more 82.64(n)    48037142 
    zebrafish
    (Danio rerio)
    Actinopterygii rps182 ribosomal protein S18 81.86(n)   192300  AY099517.1 
    soybean
    (Glycine max)
    eudicotyledons 467327032   -- 75.15(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.254872 Transcribed sequence with weak similarity to protein more 76.71(n)    CA767430.2 


    ENSEMBL Gene Tree for B3GALT4 (if available)
    TreeFam Gene Tree for B3GALT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for B3GALT4 gene
    B3GNT32  B3GNT22  B3GNT52  B3GALT52  B3GALT12  B3GNT42  B3GALT22  B3GNT72  
    B3GNT82  B3GNT62  B3GALNT12  B3GNT92  
    1 SIMAP similar gene for B3GALT4 using alignment to 2 protein entries:     B3GT4_HUMAN (see all proteins):
    B3GALT1

    Find genes that share paralogs with B3GALT4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for B3GALT4 (see all 62)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726544851,2
    F--33244782(+) GCTGGA/TCAGAC 1 -- us2k11Minor allele frequency- T:0.02NS 736
    rs1928169021,2
    C--33244800(+) ACTCCA/GTTTGG 1 -- us2k10--------
    rs726544861,2
    C--33244806(+) TTTGGT/CGCCAC 1 -- us2k11Minor allele frequency- C:0.00NS 760
    rs726544871,2
    C,F--33244810(+) GTGCCA/CCTCCA 1 -- us2k12Minor allele frequency- C:0.01NS WA 878
    rs726544881,2
    C,F--33244814(+) CACTCC/TACCCG 1 -- us2k12Minor allele frequency- T:0.01NS WA 878
    rs797687311,2
    C--33244853(+) TCCGAC/TGCCGC 1 -- us2k10--------
    rs1852940691,2
    --33245075(+) GGTCCC/GGGTCG 1 -- ut510--------
    rs726544901,2
    C,F--33245205(+) CAGCTC/GAGGCT 2 L syn13Minor allele frequency- G:0.01NS WA NA 4550
    rs2019121531,2
    --33245259(+) TGGACC/TCTCTT 2 T syn10--------
    rs22312591,2
    C--33245355(+) GCCCTG/TCCCCG 2 L syn10--------

    HapMap Linkage Disequilibrium report for B3GALT4 (33244917 - 33252609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for B3GALT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    nsv830635CNV Loss17160897
    nsv5249CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing B3GALT4
    DNA2.0 Custom Variant and Variant Library Synthesis for B3GALT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603095    OMIM disorders: --

    1 disease for B3GALT4:    
    About MalaCards
    uterine corpus cancer

    1 disease from the University of Copenhagen DISEASES database for B3GALT4:
    Uterine corpus cancer

    Find genes that share disorders with B3GALT4           About GenesLikeMe

    2 Novoseek inferred disease relationships for B3GALT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 35.7 1 15229397 (1)
    tumors 0 2 8481397 (2)

    Genetic Association Database (GAD): B3GALT4
    Human Genome Epidemiology (HuGE) Navigator: B3GALT4 (2 documents)

    Export disorders for B3GALT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for B3GALT4 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with B3GALT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta- nacetyl-galactosamine beta-1,3-galactosyltransferase family. (PubMed id 9582303)1, 2, 3, 9 Amado M.... Clausen H. (J. Biol. Chem. 1998)
    2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    3. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PubMed id 18193043)1, 4 Willer C.J....Abecasis G.R. (Nat. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. The beta 1,3-galactosyltransferase-4 (b3Gal-T4) gene is located in the centromeric segment of the human MHC class II region. (PubMed id 10663566)1, 2 Shiina T.... Inoko H. (Immunogenetics 2000)
    7. Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function. (PubMed id 21519903)1 Dong L....Ladisch S. (Glycoconj. J. 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. GM1a88/a88GD1ba88/a88GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. (PubMed id 20594196)1 Dong Y....Furukawa K. (Cancer Sci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8705 HGNC: 919 AceView: B3GALT4andRPS18andD6S2723E Ensembl:ENSG00000235863 euGenes: HUgn8705
    ECgene: B3GALT4 Kegg: 8705 H-InvDB: B3GALT4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for B3GALT4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_431

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for B3GALT4 gene:
    Search GeneIP for patents involving B3GALT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for B3GALT4   OriGene RNAi products in human, mouse, rat for B3GALT4  
     OriGene qPCR primer pairs and template standards for B3GALT4   OriGene Protein Over-expression Lysate for B3GALT4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for B3GALT4  
     OriGene qSTAR qPCR primer pairs in human, mouse for B3GALT4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for B3GALT4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for B3GALT4   OriGene Custom Protein Services for B3GALT4  

     
     
     Block miRNA regulation of human, mouse, rat B3GALT4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing B3GALT4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B3GALT4 Predesigned siRNA for gene silencing in human, mouse, rat B3GALT4
     QuantiFast Probe-based Assays in human, mouse, rat B3GALT4 QuantiTect SYBR Green Assays in human, mouse, rat B3GALT4
     Custom PCR Arrays for B3GALT4 Search Chromatin IP Primers for B3GALT4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat B3GALT4  Search GeneGlobe Interaction Network for B3GALT4
     Regulatory tfbs in B3GALT4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for B3GALT4 GenScript cDNA clones with any tag delivered in your preferred vector for B3GALT4
     GenScript Custom Assay Services for B3GALT4 GenScript Custom overexpressing Cell Line Services for B3GALT4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for B3GALT4 (B3GT4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for B3GALT4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     B3GALT4 antibodies
     B3GALT4 proteins
     B3GALT4 lysates
     Antibodies for B3GALT4
     See all of Abcam's Antibodies, Kits and Proteins for B3GALT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for B3GALT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B3GALT4
     SwitchGear 3'UTR luciferase reporter plasmids for B3GALT4
     SwitchGear Promoter luciferase reporter plasmids for B3GALT4
     ThermoFisher Antibodies for B3GALT4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B3GALT4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B3GALT4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for B3GALT4
     LSBio Antibodies in human, mouse, rat for B3GALT4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for B3GALT4
      Search eBioscience for proteins for B3GALT4
      Search eBioscience for elisas for B3GALT4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      B3GALT4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4