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Aliases & Descriptions for B3GALT4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BETA3GALT4 2 | | Beta3Gal-T4 3 | | EC 2.4.1.62 3 | | GAL-T2 3 | | GALT2 2 | | GALT4 2, 3 | | GalT4 1, 3 | | OTTHUMP00000029128 2 | | UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase 3 | | b3Gal-T4 3 | | beta3Gal-T4 1 |
| | | Descriptions |
|---|
| Beta-1,3-GalTase 4 3 | | Ganglioside galactosyltransferase 3 | | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 4 2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 2 | | beta-3-galactosyltransferase 4 2 |
|
| | Search outside databases for aliases for B3GALT4 genePrevious GC identifers: GC06U990168 GC06P033241 GC06P033237 GC06P033291 GC06P033252 |
Summaries for B3GALT4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B3GALT4: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq] UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024Function: Involved in GM1/GD1B/GA1 ganglioside biosynthesisGene Wiki entry for B3GALT4 |
Genomic Location for B3GALT4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B3GALT4 gene 
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3B3GALT4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P033352:
(about GC identifiers)
Start:
|
33,352,895 bp from pter |
End:
|
33,354,580 bp from pter |
Size:
|
1,686 bases |
Orientation:
|
plus strand |
2 alternative locations:
| Chr6+,c6_COX 33,313,589-33,315,282 | Chr6+,c6_QBL 33,316,612-33,318,297 |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113897.1
| Proteins for B3GALT4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024 (See
protein sequence)Recommended Name: Beta-1,3-galactosyltransferase 4 Size: 378 amino acids; 41537 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane proteinPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003773.1
ENSEMBL proteins: ENSP00000363756
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B3GALT4: Assays for B3GALT4: | Protein
Domains/ Families for B3GALT4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O96024
ProtoNet protein and cluster: O96024 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024Similarity: Belongs to the glycosyltransferase 31 family | Gene Function for B3GALT4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003782
Applied Biosystems Silencer® siRNAs for B3GALT4
Sigma-Aldrich siRNA for B3GALT4  Sigma-Aldrich shRNA for B3GALT4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003782                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003782                                  untagged cDNA clone in CMV expression vector: NM_003782 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003782
UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024Function: Involved in GM1/GD1B/GA1 ganglioside biosynthesisCatalytic activity: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-(1->3)-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosineEnzyme Number (IUBMB): EC 2.4.1.62 Genatlas biochemistry entry for B3GALT4:UDP galactose1 MGI phenotypic allele for B3galt4 (no phenotypes)
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008378 | galactosyltransferase activity |
IEA | -- | | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
TAS | 9582303 | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | | GO:0047915 | ganglioside galactosyltransferase activity |
IEA | -- | About this table | Pathways & Interactions for B3GALT4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for B3GALT4 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024Pathway: Protein modification; protein glycosylation 5/27 Interacting proteins for B3GALT4 (O960242 ENSP000003637563) via UniProtKB, MINT, and/or STRING (see all 27
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006486 | protein amino acid glycosylation |
TAS | 9582303 | About this table
|
Drugs & Compounds for B3GALT4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B3GALT4 10/11 Novoseek chemical compound relationships for B3GALT4 gene (see all 11
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| laccer |
95.09 |
9 |
11740154 (2), 15229397 (2), 12900410 (1), 8481397 (1) (see all 7) |
| lactosylceramide |
93.74 |
8 |
8808768 (1), 11740154 (1), 8481397 (1), 9343929 (1) (see all 7) |
| glucosylceramide |
85.89 |
10 |
8808768 (1), 9061365 (1), 11740154 (1), 8781979 (1) (see all 6) |
| glycosphingolipid |
83.82 |
3 |
11740154 (1), 8481397 (1) |
| ganglioside |
67.87 |
6 |
8536214 (1), 8005614 (1), 9582303 (1) |
| udpglucose |
66.55 |
4 |
9061365 (1), 8781979 (1), 1551920 (1) |
| ceramide |
59.93 |
2 |
11740154 (1), 1834652 (1) |
| galactose |
34.24 |
1 |
8005614 (1) |
| gtp |
30.67 |
1 |
9254052 (1) |
| lipid |
3.49 |
4 |
2129343 (2), 15229397 (1) |
About this table
|
Transcripts for B3GALT4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003782
Sigma-Aldrich siRNA for B3GALT4  Sigma-Aldrich shRNA for B3GALT4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003782 REFSEQ mRNAs for B3GALT4 gene: NM_003782.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003782               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003782                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003782                                  untagged cDNA clone in CMV expression vector: NM_003782  Additional cDNA sequence: AB026730.1 AF063595.1 AK075312.1 AK315647.1 BC032574.1 CR457093.1 CR619620.1 Y15061.1 3 DOTS entries: DT.92419828 DT.210266 DT.97788718 24/2732 AceView cDNA sequences (see all 2732
):BM459560 BQ058583 BU859886 AA360159 BQ683069 BU740293 AA301569 BM852084 BQ677276 F17992 AA844830 AI249442 BU183658 BQ676420 CB409488 BG286422 AA349284 BU627674 BU148523 AU185683 BQ958546 BM806420 AA342475 BE222652
highest scoring ESTs for B3GALT4:AV749969 BI522492 BI764671 BI772577 BI824146 BM545419 BM547323 BM712103 BM906020 BM921735 Unigene Cluster for B3GALT4: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 Hs.534375 [show with all ESTs]Unigene Representative Sequence: NM_003782
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000374626
|
Expression for B3GALT4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B3GALT4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B3GALT4
1 / 2 / 3 3 probe-sets matching B3GALT4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCCGATACG
SOURCE GeneReport for Unigene cluster: Hs.534375
Expression variation in blood from EXPOLDB for B3GALT4 UniProtKB/Swiss-Prot: B3GT4_HUMAN, O96024Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas and, to a lesser extent, in brain, placenta, kidney, liver and lung |
Orthologs for B3GALT4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B3GALT4 gene from 5/14 species (see all 14
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
B3GALT41 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
83.33(n) 83.33(a) |
481737 XM_538858.1 XP_538858.1 |
chimpanzee (Pan troglodytes) |
B3GALT41 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
99.82(n) 100(a) |
746800 XM_001170317.1 XP_001170317.1 |
rat (Rattus norvegicus) |
B3galt41 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
79.47(n) 82.29(a) |
171079 NM_133553.1 NP_598237.1 |
mouse (Mus musculus) |
B3galt41, 5 |
175
|
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more1, 5 |
80.02(n)1 81.74(a)1 |
542181 NM_019420.11 NP_062293.11 AB0391645 AB0391655 (see all 22) |
zebrafish (Danio rerio) |
rps182 |
-- |
ribosomal protein S18 |
81.86(n) |
192300 AY099517.1 |
About this table Species with no ortholog for B3GALT4
ENSEMBL Gene Tree for B3GALT4 | Paralogs for B3GALT4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B3GALT4 gene
- B3GNT52 ENSG000002146542
|
SNPs/Variants for B3GALT4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B3GALT4 (up to first 250kb)
|
Disorders & Mutations for B3GALT4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603095
2 Novoseek disease relationships for B3GALT4 gene
About this table
|
Medical News for B3GALT4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B3GALT4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/33 PubMed articles for B3GALT4 gene (see all 33
):- A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta- nacetyl-galactosamine beta-1,3-galactosyltransferase family. (PubMed id 9582303)1, 2, 3, 4 Amado M.... Clausen H. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- The beta 1,3-galactosyltransferase-4 (b3Gal-T4) gene is located in the centromeric segment of the human MHC class II region. (PubMed id 10663566)3, 4 Shiina T.... Inoko H. (2000)
- Beta1,3-galactosyltransferases-4/5 are novel tumor markers for gynecological cancers. (PubMed id 19225246)3 Seko A....Yamashita K. (2009)
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PubMed id 18193043)3 Willer C.J....Abecasis G.R. (2008)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3 Otsuki T....Isogai T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)3 Amado M.... Clausen H. (1999)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)3 Bonaldo M.F....Soares M.B. (1996)
|
Search for B3GALT4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B3GALT4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B3GALT4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GALT4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT4 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_431 |
|
| | | About This Section
| --
| Services for B3GALT4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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