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Aliases for B3GALT2 Gene

Aliases for B3GALT2 Gene

  • Beta-1,3-Galactosyltransferase 2 2 3 5
  • UDP-Galactose:2-Acetamido-2-Deoxy-D-Glucose 3beta-Galactosyltransferase 2 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase, Polypeptide 2 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,3-Galactosyltransferase 2 2 3
  • Beta-1,3-GalTase 2 3 4
  • Beta3Gal-T2 3 4
  • BETA3GALT2 3 4
  • Beta-3-Galt2 3
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • GLCT2 3

External Ids for B3GALT2 Gene

Previous GeneCards Identifiers for B3GALT2 Gene

  • GC01M190938
  • GC01M188662
  • GC01M189614
  • GC01M190436
  • GC01M189879
  • GC01M191414
  • GC01M164383

Summaries for B3GALT2 Gene

Entrez Gene Summary for B3GALT2 Gene

  • This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]

GeneCards Summary for B3GALT2 Gene

B3GALT2 (Beta-1,3-Galactosyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include galactosyltransferase activity and UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GNT5.

UniProtKB/Swiss-Prot for B3GALT2 Gene

  • Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B3GALT2 Gene

Genomics for B3GALT2 Gene

Regulatory Elements for B3GALT2 Gene

Promoters for B3GALT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B3GALT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for B3GALT2 Gene

Chromosome:
1
Start:
193,178,730 bp from pter
End:
193,186,654 bp from pter
Size:
7,925 bases
Orientation:
Minus strand

Genomic View for B3GALT2 Gene

Genes around B3GALT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B3GALT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B3GALT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B3GALT2 Gene

Proteins for B3GALT2 Gene

  • Protein details for B3GALT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43825-B3GT2_HUMAN
    Recommended name:
    Beta-1,3-galactosyltransferase 2
    Protein Accession:
    O43825
    Secondary Accessions:
    • B2RAB1
    • Q9BZQ9

    Protein attributes for B3GALT2 Gene

    Size:
    422 amino acids
    Molecular mass:
    49213 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for B3GALT2 Gene

Proteomics data for B3GALT2 Gene at MOPED

Selected DME Specific Peptides for B3GALT2 Gene

Post-translational modifications for B3GALT2 Gene

  • Glycosylation at Asn 75, Asn 100, Asn 119, Asn 176, and Asn 226
  • Modification sites at PhosphoSitePlus

Other Protein References for B3GALT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for B3GALT2 Gene

Gene Families for B3GALT2 Gene

Protein Domains for B3GALT2 Gene

Suggested Antigen Peptide Sequences for B3GALT2 Gene

Graphical View of Domain Structure for InterPro Entry

O43825

UniProtKB/Swiss-Prot:

B3GT2_HUMAN :
  • Belongs to the glycosyltransferase 31 family.
Family:
  • Belongs to the glycosyltransferase 31 family.
genes like me logo Genes that share domains with B3GALT2: view

Function for B3GALT2 Gene

Molecular function for B3GALT2 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot Function:
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.

Enzyme Numbers (IUBMB) for B3GALT2 Gene

genes like me logo Genes that share phenotypes with B3GALT2: view

Animal Models for B3GALT2 Gene

MGI Knock Outs for B3GALT2:

Animal Model Products

miRNA for B3GALT2 Gene

miRTarBase miRNAs that target B3GALT2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for B3GALT2 Gene

Localization for B3GALT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B3GALT2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B3GALT2 Gene COMPARTMENTS Subcellular localization image for B3GALT2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for B3GALT2 Gene

Pathways & Interactions for B3GALT2 Gene

genes like me logo Genes that share pathways with B3GALT2: view

Pathways by source for B3GALT2 Gene

UniProtKB/Swiss-Prot O43825-B3GT2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B3GALT2 Gene

Gene Ontology (GO) - Biological Process for B3GALT2 Gene

None

No data available for SIGNOR curated interactions for B3GALT2 Gene

Drugs & Compounds for B3GALT2 Gene

(1) Drugs for B3GALT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
genes like me logo Genes that share compounds with B3GALT2: view

Transcripts for B3GALT2 Gene

mRNA/cDNA for B3GALT2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B3GALT2 Gene

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B3GALT2 Gene

No ASD Table

Relevant External Links for B3GALT2 Gene

GeneLoc Exon Structure for
B3GALT2
ECgene alternative splicing isoforms for
B3GALT2

Expression for B3GALT2 Gene

mRNA expression in normal human tissues for B3GALT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B3GALT2 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.0), Brain - Anterior cingulate cortex (BA24) (x6.3), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Cortex (x4.6).

SOURCE GeneReport for Unigene cluster for B3GALT2 Gene Hs.518834

mRNA Expression by UniProt/SwissProt for B3GALT2 Gene

O43825-B3GT2_HUMAN
Tissue specificity: Detected in heart and brain.
genes like me logo Genes that share expression patterns with B3GALT2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for B3GALT2 Gene

Orthologs for B3GALT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for B3GALT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B3GALT2 36
  • 100 (a)
OneToOne
B3GALT2 35
  • 99.84 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia B3GALT2 36
  • 97 (a)
OneToOne
B3GALT2 35
  • 91.94 (n)
  • 97.16 (a)
dog
(Canis familiaris)
Mammalia B3GALT2 35
  • 94.55 (n)
  • 98.82 (a)
B3GALT2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B3galt2 16
B3galt2 35
  • 89.97 (n)
  • 94.55 (a)
B3galt2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia B3GALT2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B3GALT2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia B3galt2 35
  • 91.31 (n)
  • 96.21 (a)
chicken
(Gallus gallus)
Aves B3GALT2 35
  • 81.04 (n)
  • 91.23 (a)
B3GALT2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B3GALT2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487440 35
  • 75.69 (n)
  • 84.8 (a)
zebrafish
(Danio rerio)
Actinopterygii b3galt2 36
  • 65 (a)
OneToOne
b3galt2 35
  • 64.51 (n)
  • 68.59 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GALT1 35
  • 43.09 (n)
  • 28.15 (a)
rice
(Oryza sativa)
Liliopsida Os06g0229200 35
  • 44.22 (n)
  • 26.8 (a)
Species with no ortholog for B3GALT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for B3GALT2 Gene

ENSEMBL:
Gene Tree for B3GALT2 (if available)
TreeFam:
Gene Tree for B3GALT2 (if available)

Paralogs for B3GALT2 Gene

(6) SIMAP similar genes for B3GALT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B3GALT2: view

Variants for B3GALT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for B3GALT2 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv832148 CNV Gain 17160897
nsv872831 CNV Gain 21882294
esv275335 CNV Gain+Loss 21479260

Variation tolerance for B3GALT2 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B3GALT2 Gene

HapMap Linkage Disequilibrium report
B3GALT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for B3GALT2 Gene

Disorders for B3GALT2 Gene

Relevant External Links for B3GALT2

Genetic Association Database (GAD)
B3GALT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B3GALT2

No disorders were found for B3GALT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for B3GALT2 Gene

Publications for B3GALT2 Gene

  1. A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta- nacetyl-galactosamine beta-1,3-galactosyltransferase family. (PMID: 9582303) Amado M. … Clausen H. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta- galactosyltransferase catalyzing the formation of type 1 chains. (PMID: 9417100) Kolbinger F. … Katopodis A.G. (J. Biol. Chem. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein. (PMID: 18565761) Irungu J. … Desaire H. (J. Am. Soc. Mass Spectrom. 2008) 3

Products for B3GALT2 Gene

Sources for B3GALT2 Gene

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