 |
 | Services
| |
 |
Aliases & Descriptions for B3GALT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Beta3GalT1 3 | | EC 2.4.1.- 3 | | MGC126594 2 | | beta-3-galt1 2 | | beta3Gal-T1 1, 2 |
| | | Descriptions |
|---|
| Beta-1,3-GalTase 1 3 | | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 1 2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 2 | UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1 3 |
|
| | Search outside databases for aliases for B3GALT1 genePrevious GC identifers: GC02P166727 GC02P167216 GC02P168639 GC02P168878 GC02P168879 GC02P168500 |
Summaries for B3GALT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B3GALT1: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is expressed exclusively in the brain. The encoded protein shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq] UniProtKB/Swiss-Prot: B3GT1_HUMAN, Q9Y5Z6Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues |
Genomic Location for B3GALT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B3GALT1 gene 
Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24.3B3GALT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P168383:
(about GC identifiers)
Start:
|
168,383,428 bp from pter |
End:
|
168,435,612 bp from pter |
Size:
|
52,185 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for B3GALT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B3GT1_HUMAN, Q9Y5Z6 (See
protein sequence)Recommended Name: Beta-1,3-galactosyltransferase 1 Size: 326 amino acids; 37993 Da
Cofactor: Manganese (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: Q53SS2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_066191.1
ENSEMBL proteins: ENSP00000303740 ENSP00000376456
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B3GALT1: Assays for B3GALT1: | Protein
Domains/ Families for B3GALT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y5Z6
ProtoNet protein and cluster: Q9Y5Z6 1 Blocks protein family: IPB002659 Glycosyl transferase
UniProtKB/Swiss-Prot: B3GT1_HUMAN, Q9Y5Z6Similarity: Belongs to the glycosyltransferase 31 family | Gene Function for B3GALT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020981
Applied Biosystems Silencer® siRNAs for B3GALT1
Sigma-Aldrich siRNA for B3GALT1  Sigma-Aldrich shRNA for B3GALT1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020981                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020981                                  untagged cDNA clone in CMV expression vector: NM_020981 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020981
UniProtKB/Swiss-Prot: B3GT1_HUMAN, Q9Y5Z6Function: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residuesEnzyme Number (IUBMB): EC 2.4.1.- 4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008378 | galactosyltransferase activity |
IEA | -- | | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
NAS | -- | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | | GO:0030145 | manganese ion binding |
IEA | -- | About this table | Pathways & Interactions for B3GALT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: B3GT1_HUMAN, Q9Y5Z6Pathway: Protein modification; protein glycosylation 5/9 Interacting proteins for B3GALT1 (ENSP000003037403) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006486 | protein amino acid glycosylation |
NAS | -- | | GO:0009312 | oligosaccharide biosynthetic process |
IEA | -- | | GO:0030259 | lipid glycosylation |
NAS | -- | About this table
|
Drugs & Compounds for B3GALT1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B3GALT1
|
Transcripts for B3GALT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020981
Sigma-Aldrich siRNA for B3GALT1  Sigma-Aldrich shRNA for B3GALT1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020981 REFSEQ mRNAs for B3GALT1 gene: NM_020981.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020981               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020981                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020981                                  untagged cDNA clone in CMV expression vector: NM_020981  Additional cDNA sequence: AF117222.1 BC101545.1 BC104813.1 2 DOTS entries: DT.92041619 DT.120931354 6 AceView cDNA sequences:NM_020981 BX279676 AF117222 BG207694 AW196495 BV202899
highest scoring ESTs for B3GALT1:AF117222 AW196495 BG207694 BX279676 NM_020981 BC101545 BC104813 AA016019 AA016071 AA018308 Unigene Cluster for B3GALT1: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 Hs.657258 [show with all ESTs]Unigene Representative Sequence: NM_020981
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000305861
ENST00000392690
|
Expression for B3GALT1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B3GALT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B3GALT1
1 / 2 / 3 4 probe-sets matching B3GALT1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.657258 UniProtKB/Swiss-Prot: B3GT1_HUMAN, Q9Y5Z6Tissue specificity: Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells |
Orthologs for B3GALT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B3GALT1 gene from 5/13 species (see all 13
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
B3GALT11 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
92.64(n) 99.69(a) |
488386 XM_545508.2 XP_545508.2 |
chimpanzee (Pan troglodytes) |
B3GALT11 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
99.18(n) 100(a) |
459710 NM_001009096.1 NP_001009096.1 |
cow (Bos taurus) |
B3GALT11 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
91.41(n) 99.08(a) |
539027 XM_584336.3 XP_584336.2 |
rat (Rattus norvegicus) |
B3galt11 |
-- |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more |
91.1(n) 100(a) |
366064 XM_345362.3 XP_345363.1 |
mouse (Mus musculus) |
B3galt11, 5 |
25
|
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, more1, 5 |
90.49(n)1 100(a)1 |
268771 NM_020283.21 NP_064679.21 AB0391345 AB0391355 (see all 21) |
About this table Species with no ortholog for B3GALT1
ENSEMBL Gene Tree for B3GALT1 | Paralogs for B3GALT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B3GALT1 gene
- B3GALT22 B3GALNT12 B3GALT52
|
SNPs/Variants for B3GALT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B3GALT1 (up to first 250kb)
|
Disorders & Mutations for B3GALT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603093
|
Medical News for B3GALT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B3GALT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for B3GALT1 gene (see all 14
):- A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta- nacetyl-galactosamine beta-1,3-galactosyltransferase family. (PubMed id 9582303)1, 2, 3, 4 Amado M.... Clausen H. (1998)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa. (PubMed id 10356986)3, 4 Bardoni A.... Trinchera M. (1999)
- Human-specific amino acid changes found in 103 protein-coding genes. (PubMed id 15014171)4 Kitano T.... Saitou N. (2004)
- Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. (PubMed id 12925779)3 Sprong H....van Meer G. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)3 Amado M.... Clausen H. (1999)
- Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains. (PubMed id 9417100)3 Kolbinger F....Katopodis A.G. (1998)
- Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. (PubMed id 2187500)3 Kalyanaraman V.S....Sarngadharan M.G. (1990)
|
Search for B3GALT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing B3GALT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B3GALT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B3GALT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT1 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_429 |
|
| | | About This Section
| --
| Services for B3GALT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for B3GALT1:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for B3GALT1 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|