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Aliases & Descriptions for B3GALNT2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases B3GalNAc-T2 2 Beta-3-GalNAc-T2 3 EC 2.4.1.- 3 MGC39558 1 , 2 OTTHUMP00000038285 2
Descriptions Beta-1,3-N-acetylgalactosaminyltransferase II 3 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 2 UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 2 1 , 2 beta 1,3-N-acetylgalactosaminyltransferase-II (MGC39558) 2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 beta-1,3-galactosaminyltransferase 2 2
Search outside databases for aliases for B3GALNT2 genePrevious GC identifer: GC01M231940
Summaries for B3GALNT2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: B3GL2_HUMAN, Q8NCR0 Function : Beta-1,3-N-acetylgalactosaminyltransferase active in synthesizing a unique carbohydratestructure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyltransferase activity toward any acceptor substrate
Genomic Location for B3GALNT2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the B3GALNT2 gene Entrez Gene cytogenetic band: 1q42.3 Ensembl cytogenetic band: 1q42.3 HGNC cytogenetic band: 1q42.3 B3GALNT2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M233679:
(about GC identifiers )
Start:
233,679,867 bp from pter
End:
233,734,404 bp from pter
Size:
54,538 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004836.17 Proteins for B3GALNT2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: B3GL2_HUMAN, Q8NCR0 (See
protein sequence )Recommended Name: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 Size : 500 amino acids; 56704 Da
Subcellular location : Golgi apparatus membrane; Single-pass type II membrane protein (Bysimilarity)
Secondary accessions : Q59GR3 Q5TCI3 Q96AL7Alternative splicing : 2 isoforms : Q8NCR0-1 Q8NCR0-2
Post-translational modifications:
N-glycosylated (Probable)1
REFSEQ proteins: NP_689703.1 ENSEMBL proteins: ENSP00000355558 ENSP00000355559 ENSP00000315678 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for B3GALNT2: Assays for B3GALNT2:
Protein
Domains/ Families for B3GALNT2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8NCR0 ProtoNet protein and cluster: Q8NCR0
1 Blocks protein family : IPB002659 Glycosyl transferase UniProtKB/Swiss-Prot: B3GL2_HUMAN, Q8NCR0 Similarity : Belongs to the glycosyltransferase 31 family
Gene Function for B3GALNT2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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OriGene , and/or
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152490 Applied Biosystems Silencer ® siRNAs for B3GALNT2 Sigma-Aldrich siRNA for B3GALNT2 Sigma-Aldrich shRNA for B3GALNT2 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_152490                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152490                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_152490  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_152490 UniProtKB/Swiss-Prot: B3GL2_HUMAN, Q8NCR0 Function : Beta-1,3-N-acetylgalactosaminyltransferase active in synthesizing a unique carbohydratestructure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyltransferase activity toward any acceptor substrate Biophysicochemical properties : Kinetic parameters: KM=5.4 uM for UDP-GalNAc; KM=11 mM forGlcNAc-beta-Bn; Enzyme Number (IUBMB): EC 2.4.1.-
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008378 galactosyltransferase activity
IEA -- GO:0016757 transferase activity, transferring glycosyl groups
IEA --
About this table
Pathways & Interactions for B3GALNT2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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UniProtKB/Swiss-Prot: B3GL2_HUMAN, Q8NCR0 Pathway : Protein modification; protein glycosylation
1 Interacting protein for B3GALNT2 (ENSP00000355558 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006486 protein amino acid glycosylation
IEA --
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Drugs & Compounds for B3GALNT2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for B3GALNT2
Transcripts for B3GALNT2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152490 Sigma-Aldrich siRNA for B3GALNT2 Sigma-Aldrich shRNA for B3GALNT2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_152490
REFSEQ mRNAs for B3GALNT2 gene: NM_152490.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_152490
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152490                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152490                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_152490  
Additional cDNA sequence: AB209046.1 AK091497.1 AK130297.1 AK311626.1 BC016974.1 BC029564.1
11 DOTS entries : DT.40119049 DT.112386 DT.40110379 DT.452426 DT.121438830 DT.100018607 DT.121438647 DT.95236950 DT.100721410 DT.100789308 DT.95124398
24/117 AceView cDNA sequences (see all 117
):AI347669 BC029564 AL041616 BM127930 BX116951 AA971598 AL041615 NM_152490 CA418143 AI439682 CB137615 BQ221255 BQ774915 CA414713 AI289091 AA983214 AA992605 AI382500 AL046949 AA401102 AI140417 BG030855 AA052947 CB160860
highest scoring ESTs for B3GALNT2 :BC016974 BC029564 BG030855 BG720764 BG721298 CN481132 AI750563 AK130297 AL041615 AL046950
Unigene Cluster for B3GALNT2: Beta-1,3-N-acetylgalactosaminyltransferase 2 Hs.716571 [show with all ESTs ] Unigene Representative Sequence: AB209046 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for B3GALNT2 (see all 7
) ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 SP1 :     -       -       -   -   -     -     -                       SP2 :           -       -   -   -     -                           SP3 :                                               -     SP4 :     -     -   -                                         SP5 :                         -     -   -                    
About this scheme ECgene alternative splicing isoforms for B3GALNT2 3 Ensembl transcripts including schematic representations : ENST00000366599
ENST00000366600
ENST00000313984
Expression for B3GALNT2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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B3GALNT2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for B3GALNT2 1 / 2 / 3
9 probe-sets matching B3GALNT2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGAATGTAACSOURCE GeneReport for Unigene cluster: Hs.716571 UniProtKB/Swiss-Prot: B3GL2_HUMAN, Q8NCR0 Tissue specificity : Expressed in all tissues examined, but at highest levels in testis, adiposetissue, skeletal muscle and ovary
Orthologs for B3GALNT2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for B3GALNT2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for B3GALNT2 ENSEMBL Gene Tree for B3GALNT2 Paralogs for B3GALNT2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for B3GALNT2 gene B3GALT6 2
SNPs/Variants for B3GALNT2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for B3GALNT2 (up to first 250kb)
Disorders & Mutations for B3GALNT2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610194
Medical News for B3GALNT2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for B3GALNT2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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6 PubMed articles for B3GALNT2 gene : A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc. (PubMed id 14724282) 2, 3, 4 Hiruma T.... Narimatsu H. (2004) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 4 Sjoeblom T.... Velculescu V.E. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing B3GALNT2
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Specialized Databases showing B3GALNT2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
GGDB http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALNT2
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