Aliases for B2M Gene
External Ids for B2M Gene
Previous GeneCards Identifiers for B2M Gene
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
GeneCards Summary for B2M Gene
B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Hypoproteinemia, Hypercatabolic and Variant Abeta2m Amyloidosis. Among its related pathways are TNF Signaling (sino) and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include identical protein binding.
UniProtKB/Swiss-Prot for B2M Gene
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.