Aliases for B2M Gene
External Ids for B2M Gene
Previous GeneCards Identifiers for B2M Gene
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
GeneCards Summary for B2M Gene
B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Hypoproteinemia, Hypercatabolic and Variant Abeta2m Amyloidosis. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include identical protein binding.
UniProtKB/Swiss-Prot for B2M Gene
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.