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ALK Gene

protein-coding GIFtS: 66

GC02M029327

anaplastic lymphoma receptor tyrosine kinase
(Previous name: anaplastic lymphoma kinase (Ki-1) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD246 ^¹, ²
EC 2.7.10.1 ^³
TFG/ALK ^²

Descriptions
ALK tyrosine kinase receptor ^²
Anaplastic lymphoma kinase ^², ³
CD246 antigen ^², ³
anaplastic lymphoma kinase (Ki-1) ^¹
anaplastic lymphoma receptor tyrosine kinase ^²

External Ids
HGNC: 427¹
Entrez Gene: 238²
UniProtKB: Q9UM73³
Ensembl: ENSG00000171094⁷

Search outside databases for aliases for ALK gene

Previous GC identifers: GC02M029337 GC02M029508 GC02M029390

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALK:

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas

(ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma

kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2,

is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of

the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel

receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular

domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the

greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in

the development of the brain and exerts its effects on specific neurons in the nervous system.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73

Function: Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important

role in the normal development and function of the nervous system. Phosphorylates almost

exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif

Gene Wiki entry for ALK (Anaplastic_lymphoma_kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALK gene

Entrez Gene cytogenetic band: 2p23 Ensembl cytogenetic band: 2p23.1 HGNC cytogenetic band: 2p23

ALK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M029327: (about GC identifiers)

Start:	29,269,144 bp from pter
End:	29,997,936 bp from pter
Size:	728,793 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73 (See protein sequence)

Recommended Name: ALK tyrosine kinase receptor precursor

Size: 1620 amino acids; 176428 Da

Subunit: Homodimer. When bound to ligand

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structure from and Proteopedia :

2YS5 (3D)

2YT2 (3D)

Secondary accessions: Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6

Post-translational modifications:

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004295.2

ENSEMBL proteins:

ENSP00000373700

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ALK
	Millipore Purified and/or Recombinant ALK Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ALK)
	Human Recombinant Proteins from Abnova (ALK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9053841
GO:0016020	membrane	IEA	--

About this table

Antibodies for ALK:

	Invitrogen Antibodies for ALK
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALK
	R&D Systems Antibodies for ALK (ALK/CD246)
	Cell Signaling Technology (CST) Antibodies for ALK
	Antibodies from Abcam (ALK), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALK)
	Novus Biologicals Antibodies for ALK

Assays for ALK:

	Invitrogen Assays for ALK
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for ALK
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UM73

ProtoNet protein and cluster: Q9UM73

3 Blocks protein families:

IPB002011 Receptor tyrosine kinase

IPB002172 Low density lipoprotein-receptor

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor

subfamily

Similarity: Contains 1 LDL-receptor class A domain

Similarity: Contains 2 MAM domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004304

Applied Biosystems Silencer® siRNAs for ALK

Sigma-Aldrich siRNA and siRNA Panels for ALK

Sigma-Aldrich shRNA Panels and shRNA for ALK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004304
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004304
untagged cDNA clone in CMV expression vector: NM_004304

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004304

UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73

Function: Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important

role in the normal development and function of the nervous system. Phosphorylates almost

exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for ALK:

anaplastic (CD30 + large cell) lymphoma kinase playing an important role in brain

development,involved in anaplastic nodal non Hodgkin lymphoma or Hodgkin disease with

translocation t(2;5)(p23;q35) or inv2(23;q35),see NPM1

1 MGI phenotypic allele

for Alk (no phenotypes)

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	9174053
GO:0004716	receptor signaling protein tyrosine kinase activity	TAS	9053841
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ALK

5/57 Interacting proteins for ALK (ENSP00000373700³ Q9UM73^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRB	P23467¹	EBI-357361, EBI-1265766
PTPRG	P23470¹	EBI-357361, EBI-2258115
PTPRJ	Q12913¹	EBI-357361, EBI-2264500
MAP3K3	Q99759²	MINT-48477
PTN	ENSP00000341170³	STRING (score=.996)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0006487	protein amino acid N-linked glycosylation	IMP	9174053
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--
GO:0007399	nervous system development	IMP	11121404
GO:0007420	brain development	TAS	9053841

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALK
6 Novoseek chemical compound relationships for ALK gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	97.92	239	18549625 (6), 15713979 (5), 16114011 (5), 15291103 (4) (see all 77)
tyrosine	67.72	156	17681947 (4), 15226403 (4), 15938644 (3), 9174053 (3) (see all 75)
n-ipa	62.04	5	12748172 (3), 16009132 (1), 16258267 (1)
17-(allylamino)-17-demethoxygeldanamycin	39.62	4	17157164 (2), 11888936 (1)
phosphatidylinositol	14.53	1	11278720 (1)
phosphotyrosine	10.83	4	18083107 (1), 14626344 (1), 17274988 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004304

Sigma-Aldrich siRNA and siRNA Panels for ALK

Sigma-Aldrich shRNA Panels and shRNA for ALK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004304

REFSEQ mRNAs for ALK gene:

NM_004304.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004304

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004304
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004304
                                 untagged cDNA clone in CMV expression vector: NM_004304

Additional cDNA sequence:

AB209477.1 AF125093.1 AK296218.1 BX648960.1 D45915.1 U04946.1 U62540.1 U66559.1

3 DOTS entries:

DT.87014966 DT.101966450 DT.120998959

12 AceView cDNA sequences:

BG211498 BQ448051 BV183407 BX283500 BE206076 BF306767 BE019506 AA309216

U66559 NM_004304 U62540 AF362886

highest scoring ESTs for ALK:

U62540 U66559 AL525617 BE019506 BG211498 BX348694 BX366032 NM_004304 AA309216 BE206076

Unigene Cluster for ALK:

Anaplastic lymphoma receptor tyrosine kinase

Hs.654469 [show with all ESTs]

Unigene Representative Sequence: U62540

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000389048

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALK

¹ / ² / ³

6 probe-sets matching ALK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
451_at²^{, 3}	U95-A	1	1.00	1.00	0.80	1.03	U66559	1.00	0.90	0.95	1
38543_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U62540	1.00	0.90	0.95	1
208212_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004304	0.60	1.00	0.82	1
208211_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	U66559	1.00	0.90	0.95	1
208212_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208211_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.654469
Expression variation in blood from EXPOLDB for ALK
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73
Tissue specificity: Expressed in brain and CNS. Also expressed in the small intestine and testis,
but not in normal lymphoid cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALK gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALK¹	--	anaplastic lymphoma receptor tyrosine kinase	89.78(n) 92.41(a)	483021 XM_540136.2 XP_540136.2
cow (Bos taurus)	ALK¹	--	anaplastic lymphoma receptor tyrosine kinase	87.52(n) 90.14(a)	536642 XM_616782.3 XP_616782.3
mouse (Mus musculus)	Alk^{1, 5}	17 (50.00 cM)⁵	anaplastic lymphoma kinase^{1, 5}	84.77(n)¹ 88.38(a)¹	11682¹ NM_007439.2¹ NP_031465.2¹ AK051358⁵ AK158763⁵ (see all 11)
chicken (Gallus gallus)	ALK¹	--	anaplastic lymphoma kinase (Ki-1)	71.45(n) 72.45(a)	421297 XM_419364.2 XP_419364.2
zebrafish (Danio rerio)	alk¹	--	anaplastic lymphoma kinase (Ki-1)	59.86(n) 57.18(a)	563509 XM_686872.2 XP_691964.2

About this table Species with no ortholog for ALK

ENSEMBL Gene Tree for ALK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALK gene

LTK² PTK7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/4571 NCBI SNPs in ALK are shown (see all 4571 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1700)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1881420^1,2	A,C,F,H,O	29269985(-)	`GCACAA/GGGTCC`	1	K/R	mis¹ ese³		23	MN NA EA EU WA	3503
	rs1881421^1,2	A,C,F,H,O	29269870(-)	`CACGAG/CAGGGG`	1	E/D	mis¹ ese³		19	MN EU EA WA NA	3086
	rs6748439^1,2	A,C,F,H	29998637(+)	`AATACA/CTTTCA`	1	--	ng3¹		8	EU EA WA NA	624
	rs4618000^1,2	A,C,F,H	29998931(+)	`ATCCTC/TAGACA`	1	--	ng3¹		4	EU EA WA	412
	rs12714294^1,2	A,C,F,H	29999295(+)	`TCTATA/GTTTGG`	1	--	ng3¹		4	EU EA WA	420
	rs2256740^1,2	A,C,F	29308770(-)	`GGTGGT/CGCACG`	2	G/G	fra¹ ese³		1	EA	1484
	rs1670283^1,2	C,F,H	29270076(+)	`AGAGAC/TCTCTG`	1	I/V	mis¹ ese³		9	MN EU EA WA	1014
	rs1728828^1,2	C,F,H	29269296(-)	`TCTTTT/CAAATT`	1	--	ut3¹		8	MN NA EU EA WA	746
	rs7597981^1,2	A,H	29999410(+)	`ATATGC/TTCCTA`	1	--	ng3¹		4	EU EA WA	418
	rs4363989^1,2	C,H	29460171(+)	`GTATTC/ACAGGG`	1	X/E	non¹ ese³		4	EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for ALK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 105590 disorders: 256700

UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73

A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma.

Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and

the kinase becomes constitutively activated. The constitutively active fusion proteins are

responsible for 5-10% of non-Hodgkin lymphomas

A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic

tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A

A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma

(ALCL). Translocation t(2;17)(p23;q25) with ALO17

10/48 Novoseek disease relationships for ALK gene (see all 48 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anaplastic large cell lymphoma	97.72	200	8866227 (2), 11215285 (2), 16434370 (2), 19135051 (2) (see all 99)
lymphoma large cell	90.36	68	10886208 (2), 17332315 (2), 10194450 (2), 17464320 (2) (see all 33)
lymphoma	89.51	726	9415224 (7), 7655001 (5), 10994999 (4), 10505771 (4) (see all 99)
lymphomatoid papulosis	85.76	10	9415224 (2), 9638979 (1), 9250148 (1), 17325487 (1) (see all 5)
lymphoma t-cell peripheral	75.96	1	9736036 (1)
hodgkin disease	72.15	12	11697652 (2), 9638979 (1), 9490693 (1), 12500399 (1) (see all 9)
lymphoma b-cell	71.72	37	17509395 (2), 18220322 (2), 12750159 (2), 16440742 (2) (see all 17)
lymphoma non-hodgkins	70.82	22	9174053 (2), 15938644 (1), 9121481 (1), 17694547 (1) (see all 12)
pseudotumor inflammatory	63.17	4	11395553 (3)
lymphoproliferative disorders	61.35	6	15148593 (1), 17325487 (1), 8781433 (1)

About this table

Genatlas disease: ALK

nodal and extranodal,CD30+,anaplastic large-cell non Hodgkin's lymphoma,Hodgkin disease with

translocation t(2;5)(p23;q35),infalmmatory myofibroblastic tumors

Human Gene Mutation Database: ALK
Human Genome Epidemiology Navigator: ALK (2 documents)
Tumor Gene Database: ALK

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/402 PubMed articles for ALK gene (see all 402 ):

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (PubMed id 8122112)^{1, 2, 3, 4} Morris S.W....Look A.T. (1994)
Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity. (PubMed id 15938644)^{1, 3, 4} Donella-Deana A.... Pinna L.A. (2005)
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. (PubMed id 9053841)^{1, 3, 4} Iwahara T.... Yamamoto T. (1997)
Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. (PubMed id 16161041)^{1, 3, 4} Panagopoulos I.... Mandahl N. (2006)
ALK, the chromosome 2 gene locus altered by the t(2;5) in non- Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). (PubMed id 9174053)^{1, 3, 4} Morris S.W....Witte D.P. (1997)
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)^{1, 3, 4} Rikova K....Comb M.J. (2007)
The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation. (PubMed id 11387242)^{1, 3, 4} Simonitsch I.... Cerni C. (2001)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. (PubMed id 12112524)^{3, 4} Cools J.... Marynen P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 238	HGNC: 427	AceView: ALK	Ensembl:ENSG00000171094	euGenes: HUgn238
ECgene: ALK	H-InvDB: ALK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALK	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=ALK

Licensable Technologies for ALK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALK		Antibodies for ALK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies & Assays for ALK

	Recombinant Proteins (ALK)
	Antibodies (ALK)

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Antibodies for ALK

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ALK Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ALK

Summaries
for ALK

Genomic Location
for ALK

Proteins
for ALK

Protein Domains/
Families
for ALK

Gene Function
for ALK

Pathways & Interactions
for ALK

Drugs & Compounds
for ALK

Transcripts
for ALK

Expression
for ALK

Orthologs
for ALK

Paralogs
for ALK

SNPs/Variants
for ALK

Disorders & Mutations
for ALK

Medical News
for ALK

Publications
for ALK

Search for ALK

Genome Databases showing ALK

Other Databases showing ALK

Specialized Databases showing ALK

Licensable Technologies
for ALK

Services
for ALK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALK Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ALK

Summariesfor ALK

Genomic Locationfor ALK

Proteinsfor ALK

Protein Domains/Familiesfor ALK

Gene Functionfor ALK

Pathways & Interactionsfor ALK

Drugs & Compoundsfor ALK

Transcriptsfor ALK

Expression for ALK

Orthologsfor ALK

Paralogsfor ALK

SNPs/Variantsfor ALK

Disorders & Mutationsfor ALK

Medical Newsfor ALK

Publicationsfor ALK

Search for ALK

Genome Databases showing ALK

Other Databases showing ALK

Specialized Databases showing ALK

Licensable Technologiesfor ALK

Servicesfor ALK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALK

Summaries
for ALK

Genomic Location
for ALK

Proteins
for ALK

Protein Domains/
Families
for ALK

Gene Function
for ALK

Pathways & Interactions
for ALK

Drugs & Compounds
for ALK

Transcripts
for ALK

Expression
for ALK

Orthologs
for ALK

Paralogs
for ALK

SNPs/Variants
for ALK

Disorders & Mutations
for ALK

Medical News
for ALK

Publications
for ALK

Licensable Technologies
for ALK

Services
for ALK