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AGTR1 Gene

protein-coding GIFtS: 67

GC03P148415

angiotensin II receptor, type 1
(Previous name: angiotensin receptor 1B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AGTR1B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
angiotensin II receptor, type 1¹ ²		HAT1R¹ ²
AT2R1¹ ² ³ ⁵		Angiotensin II type-1 receptor² ³
AGTR1A¹ ² ³ ⁵		AT1AR² ³
AT2R1B¹ ² ³		AGTR1B² ³
AT1¹ ² ³		AT1BR² ³
AT2R1A¹ ²		type-1B angiotensin II receptor²
angiotensin receptor 1B¹ ²		AT1R²
AT1B¹ ²		angiotensin receptor 1²
AG2S¹ ²		type-1 angiotensin II receptor²

External Ids:	HGNC: 336¹	Entrez Gene: 185²	Ensembl: ENSG00000144891⁷	UniProtKB: P30556³

Search outside databases for aliases for AGTR1 gene

Previous GC identifers: GC03P145407 GC03P149300 GC03P149697 GC03P149736 GC03P149898

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AGTR1:

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important

effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of

receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of

angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood

flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed;

however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants

have been described for this gene. Additional variants have been described but their full-length nature has not been

determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.

(provided by RefSeq)

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a

phosphatidylinositol-calcium second messenger system

summary for AGTR1:

The angiotensin1 receptors (AT1) is a member of the angiotensin group of G-protein-coupled receptors that

also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where

they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell

proliferation and migration and sympathetic stimulation. Most species express a single AT1 gene, but two

related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to

chromosome 3 (3q21-q25).

Gene Wiki entry for AGTR1 (Angiotensin II receptor type 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AGTR1 gene upstream (promoter) region

:
Sp1 PPAR-gamma1 PPAR-gamma2 SRY MyoD POU2F1 MEF-2A LCR-F1 FOXO4 Nkx2-2

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for AGTR1:

MePH05582-1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q25 Ensembl cytogenetic band: 3q24 HGNC cytogenetic band: 3q21-q25

AGTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P148415: view genomic region (about GC identifiers)

Start:	148,415,571 bp from pter
End:	148,460,795 bp from pter
Size:	45,225 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.11 NT_005612.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556 (See protein sequence)

Recommended Name: Type-1 angiotensin II receptor

Size: 359 amino acids; 41061 Da

Subunit: Interacts with MAS1 (Probable). Interacts with ARRB1 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1ZV0 (3D)

Secondary accessions: Q13725

Post-translational modifications:

C-terminal Ser or Thr residues may be phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_000676.1 NP_004826.2 NP_033611.1 NP_114038.1 NP_114438.1

ENSEMBL proteins:

ENSP00000273430 ENSP00000419422 ENSP00000385612 ENSP00000419783 ENSP00000418084 ENSP00000418851

ENSP00000420757 ENSP00000385641

Human Recombinant Proteins

	Millipore Purified and/or Recombinant AGTR1 Protein
	Sigma-Aldrich Proteins for AGTR1
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for AGTR1
	HuPro® and/or Recombinant Proteins from Abnova for AGTR1
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for AGTR1
	Novus Biologicals Lysate for AGTR1
	Browse Sino Biological Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	IC	1378723
GO:0016021	integral to membrane	NAS	8135787

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AGTR1 for ontologies About GeneDecksing

Antibodies for AGTR1:

	Millipore Mono- and Polyclonal Antibodies for the study of AGTR1
	Sigma-Aldrich Antibodies for AGTR1
	Browse R&D Systems for Antibodies
	Monoclonal and Polyclonal Antibodies from Abnova (AGTR1)
	Origene Antibodies: AGTR1
	Novus Biologicals Antibodies for AGTR1
	Browse antibodies at Epitomics

Assays for AGTR1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for AGTR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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AGTR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000190 ATII_AT1_rcpt

IPR017452 GPCR_Rhodpsn_supfam

IPR000248 ATII_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P30556

ProtoNet protein and cluster: P30556

2 Blocks protein families:

IPB000190 AT1 angiotensin II receptor signature

IPB000248 Angiotensin II receptor signature

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGTR1)
		Origene 29mer shRNA kits in GFP-retroviral vector: AGTR1 Origene shRNA RFP: AGTR1 Origene basic RS shRNA: AGTR1
		Applied Biosystems Silencer® siRNAs for AGTR1
		Sigma-Aldrich siRNA Panels and siRNA for AGTR1 Sigma-Aldrich shRNA Panels and shRNA for AGTR1 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Millipore Clones for the Expression of AGTR1
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector (see all 5): AGTR1 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): AGTR1 Origene untagged cDNA clones in CMV expression vector (see all 6): AGTR1
		Sino Biological Human cDNA Clone for AGTR1

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Function: Receptor for angiotensin II. Mediates its action by association with G proteins that activate a

phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for AGTR1:

angiotensin II (type-1) receptor,G protein coupled receptor superfamily,including two subtypes AT1A and AT1B,major

blood pressure regulator (activation of vascular growth),inhibiting adenylate cyclase,activating phospholipase C and

A2,contributing in association with ACE to the risk of coronary disease,localized in the substantia nigra, the caudate

nucleus and putamen (neuromodulator),blood vessels ,heart (conduction system) and kidney (renal medullary interstitial

cells)

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001596	angiotensin type I receptor activity	IPI	1378723
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004945	angiotensin type II receptor activity	IDA	1567413
GO:0005515	protein binding	IPI	15611106

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AGTR1 for ontologies About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Agtr1a):

behavior/neurological	cardiovascular system	growth/size	hematopoietic system	homeostasis/metabolism
lethality-postnatal	renal/urinary system

AGTR1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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AGTR1 for pathways About GeneDecksing

5 Millipore Pathways for AGTR1

	Development Angiotensin signaling via PYK2
	Development Angiotensin signaling via beta-Arrestin
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Cell adhesion Integrin inside-out signaling
	Development Angiotensin activation of ERK

5 Sigma-Aldrich "Your Favorite Gene" Pathways for AGTR1 (Your Favorite Gene powered by Ingenuity)

	p70S6K Signaling
	cAMP-mediated Signaling
	Hepatic Fibrosis / Hepatic Stellate Cell Activation
	Renin-Angiotensin Signaling
	G-Protein Coupled Receptor Signaling

2 GeneAssist Pathways for AGTR1

	JAK-STAT Pathway
	Renin-Angiotensin Pathway

4 Kegg Pathways (Kegg details for AGTR1):

	hsa04020 Calcium signaling pathway
	hsa04080 Neuroactive ligand-receptor interaction
	hsa04270 Vascular smooth muscle contraction
	hsa04614 Renin-angiotensin system

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AGTR1

5/13 Interacting proteins for AGTR1 (ENSP00000273430³ P30556²) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAQ	P50148²	STRING: ENSP00000286548 MINT-4791922
ARRB1	P49407²	MINT-4791905
AGTR2	ENSP00000360973³	STRING: ENSP00000360973
ARF6	ENSP00000298316³	STRING: ENSP00000298316
ADRBK1	ENSP00000312262³	STRING: ENSP00000312262

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5/25 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 25 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	NAS	17159080
GO:0001822	kidney development	IMP	16116425
GO:0002018	renin-angiotensin regulation of aldosterone production	NAS	17159080
GO:0002034	regulation of blood vessel size by renin-angiotensin	IC	10993080
GO:0003078	regulation of natriuresis	NAS	17159080

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AGTR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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AGTR1 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for AGTR1

Sigma-Aldrich Small Molecules for AGTR1:

Small Molecule - Inhibitor Small Molecule - Antagonist Small Molecule - Agonist

Compounds for AGTR1 available from Tocris Bioscience

Compound	Action	CAS number
EMD 66684	Potent, selective non-peptide AT1 antagonist	[187683-79-0]
ZD 7155 hydrochloride	Selective non-peptide AT1 antagonist	[146709-78-6]
Saralasin	Non-selective angiotensin II antagonist	[34273-10-4]
Angiotensin II	Potent vasoconstrictor peptide	[68521-88-0]
Losartan potassium	Selective, nonpeptide AT1 antagonist	[124750-99-8]

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10/483 Novoseek chemical compound relationships for AGTR1 gene (see all 483 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
olmesartan	100.00	94	18434761 (2), 18049031 (2), 17608670 (2), 17229913 (2) (see all 84)
candesartan	100.00	252	18650791 (6), 18854846 (3), 17044086 (3), 16675585 (3) (see all 100)
irbesartan	100.00	101	18464745 (6), 20155455 (2), 18460596 (2), 16138263 (2) (see all 83)
losartan	100.00	884	9314418 (6), 9734478 (4), 9661134 (4), 8023970 (4) (see all 100)
pd123319	100.00	141	9740612 (2), 9336375 (2), 7881743 (2), 18095594 (2) (see all 100)
valsartan	100.00	145	19307231 (5), 20100990 (3), 9369273 (2), 19791474 (2) (see all 100)
telmisartan	100.00	95	16938288 (8), 18158351 (4), 19004932 (3), 17122147 (3) (see all 69)
pd123177	86.76	42	9281434 (2), 8221742 (2), 1423940 (2), 9493859 (1) (see all 39)
cgp42112a	66.08	34	8675601 (2), 8243303 (2), 12364356 (2), 9761285 (1) (see all 31)
aldosterone	58.61	164	18326554 (6), 19762686 (5), 9430819 (3), 18162560 (3) (see all 100)

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2 PharmGKB drug compound relationships for AGTR1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
losartan	PK GN	11966404
perindopril	PD	8952600

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AGTR1)
		Applied Biosystems Silencer® siRNAs: NM_000685 NM_004835 NM_009585 NM_031850 NM_032049
		Origene 29mer shRNA kits in GFP-retroviral vector: AGTR1 Origene shRNA RFP: AGTR1 Origene basic RS shRNA: AGTR1
		Sigma-Aldrich siRNA Panels and siRNA for AGTR1 Sigma-Aldrich shRNA Panels and shRNA for AGTR1 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate AGTR1:

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_000685 NM_004835 NM_009585 NM_031850 NM_032049

Clones:

Origene GFP tagged cDNA clones in CMV expression vector (see all 5): AGTR1
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): AGTR1
Origene untagged cDNA clones in CMV expression vector (see all 6): AGTR1

Primers:		Origene genome-wide validated SYBR primer pairs: AGTR1
		SABiosciences RT2 qPCR Primer Assay for AGTR1: PPH02362A

REFSEQ mRNAs for AGTR1 gene (5 alternative transcripts):

NM_000685.4 NM_004835.3 NM_009585.3 NM_031850.2 NM_032049.2

Additional cDNA sequence:

AK291541.1 BC022447.1 BC068494.1 CR601313.1 M93394.1 S77410.1

11 DOTS entries:

DT.91753556 DT.100793614 DT.100035887 DT.100035892 DT.100737728 DT.100793608 DT.91753566 DT.95162616

DT.100793625 DT.65284361 DT.99966243

24/110 AceView cDNA sequences (see all 110 ):

CR593142 AA470024 CR600504 BU150328 AU136693 CR601313 BG536056 NM_004835

AI655268 AI911517 M93394 BV183221 AL572581 AI768584 AI016286 AL547734

AV646533 AV652107 BX417755 AI911539 BX397197 BF109945 R01616 CB989105

highest scoring ESTs for AGTR1:

D13814 S77410 AA412302 AA442719 AA470024 AI016286 AI240900 AI373895 AI378001 AI768584

Unigene Clusters for AGTR1:

Angiotensin II receptor, type 1

Hs.477887 [show with all ESTs], Hs.723124 [show with all ESTs]

Unigene Representative Sequences: M87290, NM_031850

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AGTR1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c
SP1:							-		-		-		-
SP2:
SP3:													-
SP4:					-		-		-		-		-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for AGTR1

10 Ensembl transcripts including schematic representations:

ENST00000349243 ENST00000497524 ENST00000404754 ENST00000475166 ENST00000475347 ENST00000474935

ENST00000461609 ENST00000468938 ENST00000480664 ENST00000402260

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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AGTR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AGTR1

¹ / ² / ³

7 probe-sets matching AGTR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
346_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.03	D13814	1.00	1.00	1.00	1
37983_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.33	S77410	1.00	1.00	1.00	1
88568_at²^{, 3}	U95-D	1	0.62	1.00	0.54	0.66	AI654811	0.40	1.00	0.76	1
205357_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000685	0.60	1.00	0.82	1
208016_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004835	0.60	1.00	0.82	1
205357_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208016_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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AGTR1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TTCGAAACCT

SOURCE GeneReport for Unigene clusters: Hs.477887 Hs.723124

Expression variation in blood from EXPOLDB for AGTR1

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Tissue specificity: Liver, lung, adrenal and adrenocortical adenomas

Primers:		Origene genome-wide validated SYBR primer pairs: AGTR1
		SABiosciences RT2 qPCR Primer Assay for AGTR1: PPH02362A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for AGTR1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	AGTR1¹	--	angiotensin II receptor, type 1	99.72(n) 99.72(a)	460762 XM_001136214.1 XP_001136214.1
cow (Bos taurus)	AGTR1¹	--	angiotensin II receptor, type 1	91.18(n) 95.26(a)	281607 NM_174233.2 NP_776658.1
rat (Rattus norvegicus)	Agtr1¹	--	angiotensin II receptor, type 1	86.35(n) 94.71(a)	24180 NM_030985.3 NP_112247.2
mouse (Mus musculus)	Agtr1a^{1, 5}	13 (16.00 cM)⁵	angiotensin II receptor, type 1a^{1, 5}	87(n)¹ 94.43(a)¹	11607¹ NM_177322.2¹ NP_796296.1¹ AI551199⁵ AI593508⁵ (see all 10)
chicken (Gallus gallus)	AGTR1¹	--	angiotensin II receptor, type 1	73.82(n) 75.77(a)	396065 NM_205157.2 NP_990488.1

About this table Species with no ortholog for AGTR1

ENSEMBL Gene Tree for AGTR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AGTR1 gene

BDKRB1² RXFP3² GPR25² APLNR² BDKRB2² GPR15² AGTR2² RXFP4²

AGTR1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/435 NCBI SNPs in AGTR1 are shown (see all 435 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 199)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
	rs389566^1,2	C,F,O,A,H	145818755(+)	`GATCCA/TGAAAT`	5	--	ng5¹ int¹		27	EA NS NA WA	3282
--	rs422858^1,2	C,F,A,H	145787857(-)	`TCACGCT/G /GG/TGGTCC`	4	--	ng5¹		4	NS EA	418
	rs388915^1,2	C,F,A,H	145820132(+)	`TGCTCA/GCAGGG`	5	--	ng5¹ int¹		16	MN EA NS NA WA	2818
--	rs387967^1,2	C,F,A	145787858(-)	`TTCACG/CGGGTC`	4	--	ng5¹		4	MN NA EA	346
--	rs12721226^1,2	C,F,H	148459309(+)	`TGCCAG/ACTATA`	10	/T /A	mis¹ ref¹		6	NS EA	542
--	rs275650^1,2	C,F,A	145786932(-)	`ATAAAT/ATTAAA`	4	--	ng5¹ tfbs³		9	NS NA EA WA	926
	rs12721256^1,2	C,F,H	145819810(+)	`GGCATC/TGGTGT`	5	--	ng5¹ int¹		7	NS EA	1104
--	rs12721225^1,2	C,F,H	148459552(+)	`TTATGG/TCAATT`	10	A S	ref¹ mis¹ ese³		7	NS EA	1066
	rs275651^1,2	C,F,A	145787260(-)	`atgttA/Tgatag`	4	--	ng5¹		17	NS EA NA WA	1738
	rs12695900^1,2	C,F,H	145819407(+)	`TGATGG/CTCTTG`	5	--	ng5¹ int¹		8	NS EA	1204

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HapMap Linkage Disequilibrium images for AGTR1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AGTR1: --

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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AGTR1 for disorders About GeneDecksing

OMIM: 106165 disorders: 145500 267430

UniProtKB/Swiss-Prot: AGTR1_HUMAN, P30556

Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive

severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably

due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype)

10/505 Novoseek disease relationships for AGTR1 gene (see all 505 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cardiac hypertrophy	68.46	96	20231526 (6), 9609089 (4), 9741738 (3), 19372206 (3) (see all 69)
hypertension	54.28	416	9314418 (6), 15545843 (5), 12390711 (5), 19172459 (4) (see all 100)
enzyme inhibition	50.46	60	9495257 (2), 8777826 (2), 12815575 (2), 9924854 (1) (see all 57)
essential hypertension	30.83	95	12778448 (4), 12358135 (4), 11110972 (4), 9498106 (3) (see all 63)
hypertrophies	27.01	98	19588183 (5), 9403620 (2), 15976327 (2), 14985364 (2) (see all 88)
diabetic nephropathies	26.31	66	9648845 (5), 12477969 (3), 8671962 (2), 19713965 (2) (see all 52)
hypertrophy; ventricular; left	18.16	65	15274684 (4), 8067441 (3), 19997001 (3), 11910301 (3) (see all 48)
cardiac; fibrosis	18.13	18	18049031 (6), 9719054 (3), 9349385 (1), 7536716 (1) (see all 11)
chronic heart failure	15.31	55	18768398 (5), 19717736 (4), 18660444 (4), 18566341 (4) (see all 29)
diastolic heart failure	15.25	18	12923407 (5), 19330904 (4), 19185300 (2), 19021695 (2) (see all 9)

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2 PharmGKB disease relationships for AGTR1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Hypertension	PD PK GN	11966404 8952600
Myocardial Infarction	CO GN	15454732

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Genatlas disease: AGTR1

Bartter syndrome characterized by hypokalemic alkalosis,normal or hypercalciuria,normal magnesemia,early onset and

hyperreninemia,hyperaldosteronism,hyperplasia of the juxtaglomerular apparatus

Human Gene Mutation Database: AGTR1
Genetic Association Database: AGTR1
Human Genome Epidemiology Navigator: AGTR1 (373 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1839 PubMed articles for AGTR1 gene (see all 1839 ):

Angiotensin II type I receptor gene and myocardial infarction: tagging SNPs and haplotype based association study. The Beijing atherosclerosis study. (PubMed id 15454732)^{1, 3, 7} Su S....Gu D. (2004)
Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. (PubMed id 1550596)^{2, 3, 4} Takayanagi R.... Nawata H. (1992)
1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia. (PubMed id 16076618)^{1, 3, 6} Seremak-Mrozikiewicz A....Mrozikiewicz P.M. (2005)
[A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations] (PubMed id 12778448)^{1, 3, 6} Liu Y....Qiu C.C. (2003)
[Association between early-onset coronary heart disease and angiotensin II type 1 receptor gene polymorphism] (PubMed id 12133518)^{1, 3, 6} Peng J....Gong W. (2002)
[Association between renin-angiotensin system gene polymorphism and type 2 diabetics with stroke in China] (PubMed id 11774217)^{1, 3, 6} Zhang X....Zhang S. (2001)
[Analyses on the association of CA-repeat polymorphism and A1166-->C variant in the 3'-flanking region of AT(1)R gene with essential hypertension in Tibetans] (PubMed id 11110972)^{1, 3, 6} Qiu C....Zhou W. (2000)
Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion. (PubMed id 15238568)^{1, 3, 6} Stolarz K....Grodzicki T. (2004)
Angiotensinogen and angiotensin II type 1 receptor gene polymorphism in patients with autosomal dominant polycystic kidney disease: effect on hypertension and ESRD. (PubMed id 12950120)^{1, 3, 6} Lee K.B. and Kim U.K. (2003)
Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS. (PubMed id 11926202)^{1, 3, 6} Basset e.l.-.E.A....Berthou F. (2002)

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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 185	HGNC: 336	AceView: AGTR1	Ensembl:ENSG00000144891	euGenes: HUgn185
ECgene: AGTR1	Kegg: 185	H-InvDB: AGTR1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGTR1
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1
Wikipedia	http://en.wikipedia.org/wiki/Angiotensin_receptor

Intellectual Property for AGTR1 gene
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Patent Information for AGTR1 gene:

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GeneCards and IP:

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Products for AGTR1:

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AGTR1 Gene

protein-coding GIFtS: 67

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complications; renal
minimal change glomerulonephritis
malformation
fibrosis myocardial
k deficiency
mixed cryoglobulinemia
hypoplasia; pulmonary
herpes simplex
factor v leiden
cardiovascular disease other
cystic fibrosis
neurodegenerative disease
interstitial pneumonia
interstitial nephritis
COPD
alcoholic cardiomyopathy
eccrine poroma
atherosclerosis
hypertrophy; ventricular; left
adrenal carcinoma
metaplasia
anterior myocardial infarction
hypertensive heart failure
hypoglycemia
congenital heart disease
neuroblastoma
perivascular fibrosis
diabetes mellitus insulin-dependent
volume overload
failure heart
uveitis
age-related macular degeneration
disease; liver
brain infarction
ischemia peripheral
pancreatic endocrine tumor
mass phenotype
AF
hypertensive left ventricular hypertrophy
renal artery stenosis
pancreatitis
ovarian cancer
cirrhosis (liver)
arterial thrombosis
leiomyoma
adpkd
myopathies
cognitive impairment
atherogenesis
diabetic complication
DMD
thrombus
hypertension malignant
hypertension complicated
cervical squamous cell carcinoma
fibrosis liver
abdominal aortic aneurysm
sclerosis; systemic
acute pyelonephritis
left ventricular systolic dysfunction
hyperemia
add1, gly460trp
structural dysfunction
hypotensive episode
desquamative interstitial pneumonia
malignant ventricular arrhythmias
metabolic syndrome
cardiac; hypoplasia
aortic stenosis
hypertension systolic
metastasis
cell injury
necrosis
lymph node metastasis
cardiac overload
hydronephrosis
prostate tumor
idiopathic pulmonary fibrosis
heymann nephritis
genetic hypertension
hypertensive portal gastropathy
chronic glomerulonephritis
middle cerebral artery occlusion
reflux nephropathy
atrial fibrillation
cardiac; fibrosis
astrocytoma
non-alcoholic steatohepatitis
cardiovascular abnormalities
epithelial tumor
emotional stress
renal fibrosis
hypertension; lv hypertrophy
chronic; glaucoma
acute myocardial ischemia
aortic coarctation
osteoporosis
acute cerebral ischemia
ards
agt, met235thr
infarction; myocardial, nontransmural
pituitary tumor
keratoacanthoma
cardiac death; sudden
adrenocortical carcinoma
hypertrophy; ventricular; right
chronic periodontitis
erythrocytosis
gastritis
acute ischemia
gene abnormality
autoimmune myocarditis
postinfarction
membranous nephropathies
dilatations
interstitial fibrosis
cerebrovascular disease
invasive breast cancer
chronic lung disease
vascular disease
mesangial proliferative glomerulonephritis
acute stroke
chronic heart failure
choriocarcinoma
fatty liver
disease; peripheral vascular
infertility
growth suppression
stunned myocardium
peritoneal carcinomatosis
atrial fibrillation paroxysmal
microangiopathy
sepsis
chronic inflammation
bronchial hyperresponsiveness
arrhythmia ventricular
distortion
hypertrophic scar
diabetic retinopathy proliferative
insulin sensitivity
gitelman syndrome
lung cancer
nephrosclerosis hypertensive
arteritis; giant cell
breast cancer
aneurysm cerebral
infarction; myocardial
hypercholesterolemia
damage; renal
antidiuresis
pancreatic fibrosis
nphs1
insufficiency renal
cervical intraepithelial neoplasia
diastolic heart failure
somatic mutation
vascular proliferation
shock
cerebral infarction
diabetic cardiomyopathy
hemorrhage intracerebral
pneumoniae
dominant-negative mutant
colorectal cancer
brachydactyly
diabetic nephropathies
choroidal neovascularization
aortocaval fistula
CHF
hypertension
renal impairment
nephritis autoimmune
fatty streaks
failure; myocardial
cysts
arrhythmia
hyperglycemia
cervical cancer
sarcoidosis
abdominal aortic stenosis
atrial hypertrophy
cerebral edema
vascular inflammations
diastolic dysfunction
thrombosis
hypertension; maternal
prostatic adenocarcinoma
eccentric hypertrophy
cardiovascular disease
steatosis
preeclampsia
cardiovascular pathology
colitis
hypertension, pregnancy-induced
left ventricular dilatation
gastric cancer
anhydramnios
stress related disorder
change; vascular
coronary occlusion
melanoma
post mi
malignant essential hypertension
glaucoma
reperfusion arrhythmia
tumor progression
glioma
hormone-refractory prostate cancer
aldosteronism primary
angina stable
carcinoma; renal cell
fetal hypoxia
hypertensive heart disease
hormone replacement
varicose vein
disease parkinsons
obese
disease; inflammatory bowel
eruption
fibrosis pulmonary
acute nephritis
ventricular dysfunction
myocarditis
disturbance; circulatory
disorder; metabolic
cardiovascular morbidity
metastatic renal cell carcinoma
ovary; polycystic (syndrome)
anastomosis
enzyme inhibition
pancreatic tumor
insulin resistance
sodium retention
disease; lung
venoconstriction
aneurysm aortic
familial hypercholesterolemia
VSD
solid tumor
cardiomyopathy hypertensive
hypoglossal nerve lesion
angina unstable
hepatic impairment
renal hypoplasia
complicated pregnancy
cerebral ischemia
obstructive sleep apnea
glomerulonephritis
hypertension; renovascular
endometrial cancer
mitral (valve) prolapse
angiotensin hypertension
acute infarct
microalbuminuria
down syndrome
glucose tolerance impaired
proliferative retinopathy
generalized aggressive periodontitis
endometriosis
anginal attack
renal hypertrophy
pancreatic ductal adenocarcinoma
dysplasia
end organ damage
tumor growth
bleeding breakthrough
lung metastases
left ventricular dysfunction
naion
edema
lesion; vascular
diabetic retinopathies
nephrotic syndrome
sarcoma 180
ureteral obstruction
coronary stenosis
adrenarche; premature
aortic regurgitation
nephropathy obstructive
cancer
obstruction
tumor necrosis
hypertension pulmonary
adenoma; pituitary
aneurysm
diabetic microangiopathies
preterm infant
basal cell carcinoma
sweat gland tumor
cor pulmonale
atrophies
ulcer
hypertension secondary
testicular torsion
sudden cardiac arrest
acute renal failure
bilateral renal artery stenosis
ring; vascular
cardiomyopathy dilated
inflammatory cell infiltration
mucinous tumor
congenital muscular dystrophy
hypertrophy; ventricular
endothelial dysfunction
pheochromocytoma
hypotensive
glucose-6-phosphate dehydrogenase deficiency
myocarditis; viral
renal ischemia
retinal vascular
heart rate increased
urogenital cancer
failure; renal
renal dysplasia
aortic root dilatation
interstitial inflammation
hyperplasia
dysfunction; myocardial
atherosclerotic plaque
renal interstitial fibrosis
cystadenoma
cardiovascular complication
RA
gene insertion
aortic dissection
fsgs
iga nephropathies
infarct
squamous cell carcinoma
congenital diaphragmatic hernia
leukemia
early cirrhosis
erectile dysfunction
diabetes mellitus
compensatory hypertrophy
contracture
poor glycemic control
arteriosclerosis
damage; vascular
pregnancy early
pancreatic cancer
gastric ulcer
sspe (subacute sclerosing panencephalitis)
myocardial stunning
diabetic complications renal
nonalcoholic steatohepatitis
cerebral ventricle
hypertrophies
chronic renal failure
aorta constriction
previous myocardial infarction
persistent pulmonary hypertension
eosinophilia
adenoma
infant vlbw
nphs2
polycystic kidney disease
ischemic stroke
xenograft model
CAD
acute mountain sickness
autoimmune
cardiomyopathies
Becker muscular dystrophy
liddle syndrome
goldblatt hypertension
dcis
inflammatory response
fistula
dementia
tumor angiogenesis
nephritis
migraine
hivan
hyperinsulinemia
essential hypertension
cardiac; lesion, congenital
disease; kawasaki
acute myocardial infarction
sclerosis
peyronie disease
hypoxic
cellular stress
glomerular disease
iugr
edema pulmonary
hyperlipidemia
glomerulonephritis membranoproliferative
diabetes; type 2
ischemia
death (sudden)
aldosteronoma
fibromuscular dysplasia
acute anterior myocardial infarction
pulmonary arterial hypertension
cancer cell growth
bartter syndrome
cholestasis
asthma
disease; urological
venous thromboembolism
coronary collateral circulation
obstructive uropathy
dilatation ventricular
brain; ischemic
renal scarring
coronary atherosclerosis
cardiovascular risk factor
dyslipidemia
recurrent urinary tract infection
acute pancreatitis
chronic hyperglycemia
idiopathic interstitial pneumonia
malnutrition
glomerulosclerosis
inflammation
proteinuria
tuberculosis
coronary thrombosis
fascination
hyperaldosteronism, familial, type ii
glomerulopathy
failure liver
hypertension uncomplicated
neurogenic hypertension
endometrial endometrioid adenocarcinoma
prostate cancer
bladder dysfunction
hyperoxaluria
carcinoma hepatocellular
sarcoma
nephrogenic systemic fibrosis
disease; ischemic heart
hypersensitivities
glioblastoma
hypertension renal
carotid atherosclerosis
glomerulonephritis proliferative
marfan syndrome
cushing syndrome
necrosis; tubular
hyponatremia
corneal neovascularization
dysplasia; epithelial
stemi
phenomenon; raynaud
hyperuricemia
disease; heart
adrenocortical tumor
bladder cancer
malignant renovascular hypertension
scleroderma renal crisis
invasive carcinoma
lipid deposition
diseases; multiple
increased growth
osteoarthritis
postural tachycardia syndrome
VUR
congestive heart failure treated
thrombosis venous
neurodegeneration
systolic heart failure
nephrosclerosis
chronic hepatitis c
pulmonary tuberculosis
nuclear accumulation
uremia
influenza
CKD
nephrosis
renal disease progressive
adrenocortical adenoma
hypertension portal
retinopathies
lacunar infarction
peripheral arterial disease
skin cancer
dementia vascular
cardia
pathological angiogenesis
rheumatic mitral valve disease
nephropathies
restenosis
cardiac hypertrophy
cerebral artery occlusion
adult disease
adrenal tumor
hemochromatosis
stroke
retinal neovascularization
liver metastases
cholera
mediastinal mass
syndrome x
ovarian tumor
mesangial proliferation
hot spots
synovitis
ovarian adenocarcinoma
reflux; vesicoureteral
dystrophy (muscular)
juxtaglomerular cell tumor
arthritis

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AGTR1 Gene

protein-coding GIFtS: 67

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