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ADRA2A Gene

protein-coding   GIFtS: 61

GC10P112826
adrenergic, alpha-2A-, receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ADRA2, ADRA2R)
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Aliases &
Descriptions
for ADRA2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
adrenergic, alpha-2A-, receptor1 2     ZNF322
ADRAR1 2 3     ALPHA2AAR2
ADRA2R2 3 5     alpha-2-adrenergic receptor, platelet type2
Alpha-2A adrenoceptor2 3     ADRA22
Alpha-2A adrenoreceptor2 3     alpha-2AAR subtype C102
Alpha-2 adrenergic receptor subtype C102 3     Alpha-2AAR3
alpha-2A adrenergic receptor2     

External Ids:    HGNC: 2811   Entrez Gene: 1502   Ensembl: ENSG000001505947   UniProtKB: P089133   

Search outside databases for aliases for ADRA2A gene

Previous GC identifers: GC10P111730 GC10P112070 GC10P112968 GC10P112501

Summaries
for ADRA2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for ADRA2A:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating
neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in
mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter
release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited
transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower
levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or
untranslated sequences. (provided by RefSeq)

UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the
action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >
epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For
antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin >
propanolol > alprenolol = pindolol

"" summary for ADRA2A:
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of
G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic
alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed
in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission,
smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been
identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

Gene Wiki entry for ADRA2A (Alpha-2A adrenergic receptor)

Genomic Views
for ADRA2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the ADRA2A gene upstream (promoter) region "":
E2F   E2F-1   AREB6   E47   c-Myc   Max1   Arnt   Bach1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for ADRA2A:  ""
MePH14280-3A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q26   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q24-q26

ADRA2A Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P112826:  view genomic region     (about GC identifiers)

Start:
 112,836,790 bp from pter
End:
 112,840,665 bp from pter
Size:
 3,876 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

Proteins
for ADRA2A gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913 (See protein sequence)
Recommended Name: Alpha-2A adrenergic receptor  
Size: 450 amino acids; 48957 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from "" and Proteopedia "" :
1HLL (3D) ""    1HO9 (3D) ""    1HOD (3D) ""    1HOF (3D) ""    
Secondary accessions: B0LPF6 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_000672.3  

    ENSEMBL proteins: 
    ENSP00000280155 ENSP00000397995 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant ADRA2A Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Browse recombinant and purified proteins available from Enzo Life Sciences
    ""HuPro® and/or Recombinant Proteins from Abnova for ADRA2A ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Protein for ADRA2A  ""
    Novus Biologicals Lysate for ADRA2A
    ""Browse Sino Biological Recombinant Proteins  ""

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS1354394
    GO:0016021 integral to membrane ----
    About this table

    "" ADRA2A for ontologies           About GeneDecksing



    Antibodies for ADRA2A: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for ADRA2A
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (ADRA2A)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for ADRA2A
    ""Browse antibodies at Epitomics

    Assays for ADRA2A: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Browse Enzo Life Sciences for kits & assays

    Protein Domains/
    Families
    for ADRA2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" ADRA2A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR002233 Adrnrgc_rcpt
     IPR001946 Adren_rcpt_A2A
     IPR015695 Adren_rcpt_A2A/B/C
     IPR000276 7TM_GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08913

    ProtoNet protein and cluster: P08913

    2 Blocks protein families:
    IPB001946 Alpha-2A adrenergic receptor signature
    IPB002233 Adrenergic receptor signature


    UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
    Similarity: Belongs to the G-protein coupled receptor 1 family

    Gene Function
    for ADRA2A gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ADRA2A)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: ADRA2A
    Origene shRNA RFP: ADRA2A
    Origene basic RS shRNA: ADRA2A

    ""Applied Biosystems Silencer® siRNAs for ADRA2A
    ""Sigma-Aldrich siRNA Panels and siRNA for ADRA2A
    Sigma-Aldrich shRNA Panels and shRNA for ADRA2A
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Millipore Clones for the Expression of ADRA2A
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): ADRA2A
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ADRA2A
    Origene untagged cDNA clones in CMV expression vector (see all 2): ADRA2A
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: ADA2A_HUMAN, P08913
    Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the
    action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine >
    epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For
    antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin >
    propanolol > alprenolol = pindolol

    Genatlas biochemistry entry for ADRA2A:
    adrenergic,alpha-2A-,receptor,G protein coupled receptor superfamily,inhibiting formation of cAMP opening K+
    channels,inhibiting Ca2+ channels

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0004935 adrenoceptor activity IEA--
    GO:0004938 alpha2-adrenergic receptor activity IEA--
    GO:0005515 protein binding IEA--
    About this table

    "" ADRA2A for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 3 alleles"") (MGI details for Adra2a):

    cardiovascular systemembryogenesishomeostasis/metabolismlethality-prenatal/perinatalnervous system
    normal

    "" ADRA2A for phenotypes           About GeneDecksing

    Pathways & Interactions
    for ADRA2A gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" ADRA2A for pathways           About GeneDecksing

    1 "" Millipore Pathway for ADRA2A
      ""  Development Alpha-2 adrenergic receptor activation of ERK

    5 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  ADRA2A  (Your Favorite Gene powered by Ingenuity)
      ""  AMPK Signaling
    ?-Adrenergic Signaling
    G-Protein Coupled Receptor Signaling
    cAMP-mediated Signaling
    Cardiac Hypertrophy Signaling

    5 "" GeneAssist Pathways for ADRA2A
      ""  AMPK Enzyme Complex Pathway
    Activation of cAMP-Dependent PKA
    cAMP Pathway
    Alpha-Adrenergic Signaling
    Signaling Involved in Cardiac Hypertrophy

    1 "" Kegg Pathway  (Kegg details for ADRA2A):
      ""  hsa04080 Neuroactive ligand-receptor interaction

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADRA2A

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187 activation of MAPK activity TAS10896916
    GO:0006928 cellular component movement TAS9624180
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway EXP18240029
    GO:0007194 negative regulation of adenylate cyclase activity TAS10896916
    About this table

    "" ADRA2A for ontologies           About GeneDecksing


    Drugs & Compounds
    for ADRA2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" ADRA2A for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for ADRA2A
    ""Sigma-Aldrich Small Molecules for ADRA2A:
    Small Molecule - Antagonist Small Molecule - Agonist Small Molecule - Mixed Agonist/Antagonist Small Molecule - Blocker

    "" Compounds for ADRA2A available from Tocris Bioscience
    CompoundAction CAS number
    BRL 44408 maleateSelective alpha2A antagonist[118343-19-4]
    Medetomidine hydrochloridePotent, highly selective alpha2 agonist[106807-72-1]
    About this table


    10/287 ""Novoseek chemical compound relationships for ADRA2A gene (see all 287 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    clonidine 100.00 150 9374797 (4), 19120051 (4), 6304444 (3), 6291932 (3) (see all 100)
    yohimbine 100.00 119 6292392 (3), 8134313 (2), 6319226 (2), 6291538 (2) (see all 100)
    norepinephrine 67.60 150 8554738 (5), 9223561 (4), 1361869 (3), 9415717 (2) (see all 100)
    epinephrine 50.44 79 9422350 (5), 9209252 (3), 3779100 (3), 3005307 (3) (see all 63)
    idazoxan 38.22 27 1972387 (2), 9483533 (1), 9481969 (1), 9347254 (1) (see all 26)
    prazosin 35.87 40 2885271 (3), 7048423 (2), 9483533 (1), 9378566 (1) (see all 37)
    adenylate 32.67 57 8099279 (3), 6327751 (3), 7755576 (2), 2981397 (2) (see all 48)
    dexmedetomidine 23.84 24 9597647 (3), 9098987 (1), 8933759 (1), 8735417 (1) (see all 22)
    agmatine 23.40 18 11471213 (3), 11501047 (2), 11270988 (2), 11270972 (2) (see all 12)
    guanfacine 15.05 11 12351753 (4), 19276088 (2), 2417047 (1), 17786553 (1) (see all 7)
    About this table

    3 PharmGKB drug compound relationships for ADRA2A gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    Beta adrenergic antagonistsFA  9174358
    sibutraminePD  12781566
    yohimbinePD  9663918
    About this table


    Transcripts
    for ADRA2A gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ADRA2A)
    ""Applied Biosystems Silencer® siRNAs:  NM_000681  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: ADRA2A
    Origene shRNA RFP: ADRA2A
    Origene basic RS shRNA: ADRA2A

    ""Sigma-Aldrich siRNA Panels and siRNA for ADRA2A
    Sigma-Aldrich shRNA Panels and shRNA for ADRA2A
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""Search SABiosciences for microRNAs that regulate ADRA2A: ""
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_000681  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): ADRA2A
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ADRA2A
    Origene untagged cDNA clones in CMV expression vector (see all 2): ADRA2A
    Primers:"" Origene genome-wide validated SYBR primer pairs: ADRA2A
    ""SABiosciences RT2 qPCR Primer Assay for ADRA2A: PPH02695A ""

    REFSEQ mRNAs for ADRA2A gene: 

    NM_000681.3  

    Additional cDNA sequence: 

    AF284095.1 BC035047.1 BC050414.1 

    2 DOTS entries:

    DT.101972051  DT.453118 

    24/70 AceView cDNA sequences (see all 70 ):

    T08946 AI597708 F03845 BC035047 BF725008 T16471 AW075300 F09185 
    AI147682 BM723451 BM695296 AW513366 CB045497 AW196450 H89355 BF725007 
    T34699 Z40854 AI572103 AW241599 AI656344 AW513365 AA885436 AI131333 

    "" highest scoring ESTs for ADRA2A:

    AI651732 AA328564 AA513474 AA885436 AF284095 AI131333 AI147682 AI572103 AI597708 AI656344 

    Unigene Cluster for ADRA2A:

    Adrenergic, alpha-2A-, receptor
    Hs.249159  [show with all ESTs]
    Unigene Representative Sequence: NM_000681


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000280155  ENST00000449894  

    Expression
    for ADRA2A gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    ADRA2A expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for ADRA2A

    1""  / 2""  / 3""

    4 probe-sets matching ADRA2A gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    264_at2, 3 U95-A 1 0.88 1.00 -0.16 0.43 M23533 0.20 1.00 0.72 1
    64888_at2, 3 U95-C 1 0.50 1.00 1.00 1.00 AI651732 1.00 1.00 1.00 1
    209869_at2, 3 U133-A 1 0.27 1.00 -- -- AF284095 0.80 1.00 0.91 1
    209869_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    "" ADRA2A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.249159

    Expression variation in blood from EXPOLDB for ADRA2A

    Primers:"" Origene genome-wide validated SYBR primer pairs: ADRA2A ""
    ""SABiosciences RT2 qPCR Primer Assay for ADRA2A: PPH02695A ""

    Orthologs
    for ADRA2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for ADRA2A gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ADRA2A1   -- adrenergic, alpha-2A-, receptor 93.24(n)
    93.14(a)    		 486888  XM_544018.2  XP_544018.2 
    chimpanzee
    (Pan troglodytes)    		 ADRA2A1   -- adrenergic, alpha-2A-, receptor 98.99(n)
    98.23(a)    		 466201  XM_521603.2  XP_521603.2 
    cow
    (Bos taurus)    		 ADRA2A1   -- adrenergic, alpha-2A-, receptor 90.35(n)
    91.76(a)    		 282135  NM_174499.1  NP_776924.1 
    mouse
    (Mus musculus)    		 Adra2a1, 5 19 (50.00 cM)5
    		 adrenergic receptor, alpha 2a1, 5 87.7(n)1
    92.22(a)1    		 115511  NM_007417.21  NP_031443.21 
     AK0468025  AK1385185  (see all 13)
    zebrafish
    (Danio rerio)    		 adra2a1   -- adrenergic, alpha-2A-, receptor 66.23(n)
    69.82(a)    		 266750  NM_207637.2  NP_997520.2 
    About this table        Species with no ortholog for ADRA2A

    ENSEMBL Gene Tree for ADRA2A

    Paralogs
    for ADRA2A gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for ADRA2A gene
    HTR62  HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HRH22  HTR2C2  
    ADRA1A2  DRD32  HTR1B2  ADRB12  ADRA1B2  HTR2B2  ADRA2C2  HTR72  
    DRD12  ADRB22  HTR1D2  ADRA2B2  HTR42  DRD52  ADRB32  HTR1E2  
    HTR5A2  ADRA1D2  

    "" ADRA2A for paralogs           About GeneDecksing


    Genomic Variants
    for ADRA2A gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/38 NCBI SNPs in ADRA2A are shown (see all 38 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 53)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs18005451,2
    		C,F,A,H112837538(+) AAGGCG/ACCCAC 1 -- ut51 ese3""8Minor allele frequency- A:0.16MN NS NA 791""
    ""
    rs5536681,2
    		C,F,A112839579(-) TTCTTC/TAAAAA 1 -- ut31 ese3""15Minor allele frequency- T:0.36EA MN NS NA WA 2719""
    ""
    rs5216741,2
    		C,F,A106464354(+) CCTTAA/TTGAAG 1 -- ng51 tfbs3""15Minor allele frequency- T:0.45EA NA NS WA 1278""
    ""
    rs111954191,2
    		C,F,A112839368(+) TTTGGC/ACACTC 1 -- ut31 ese3""19Minor allele frequency- A:0.20MN NS EA NA WA 1677""
    ""
    rs24845161,2
    		C,F,H112837073(+) GTCCCC/GGAGCT 1 -- ut51 ese3""6Minor allele frequency- G:0.04NS NA 578""
    ""
    rs18005441,2
    		C,F,A106465267(+) GGCCCC/GGAGCT 1 -- ng51""7Minor allele frequency- G:0.35NS NA EA 686""
    --
    rs772868011,2
    		C,F112839049(+) CTACTG/TCAACA 2 C F ref1 mis1""1Minor allele frequency- T:0.03NA 72""
    --
    rs70890691,2
    		C,F106465028(+) GGGTTC/TCATCC 1 -- ng51""3Minor allele frequency- T:0.03NS 548""
    ""
    rs18000351,2
    		C,F112838552(+) CCCAAC/GGGTCT 2 N K ref1 mis1""2Minor allele frequency- G:0.07NS 92""
    --
    rs133061441,2
    		C,F112839903(+) TGCCTA/GACAGC 1 -- ut31 ese3""1Minor allele frequency- G:0.07EA 88""
    About this table

    HapMap Linkage Disequilibrium images for ADRA2A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for ADRA2A: --

    Disorders & Mutations
    for ADRA2A gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" ADRA2A for disorders           About GeneDecksing

    OMIM: 104210

    10/108 ""Novoseek disease relationships for ADRA2A gene (see all 108 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adhd 21.73 44 16806103 (5), 16917924 (4), 16389583 (4), 12815749 (4) (see all 20)
    phenomenon; raynaud 8.45 12 3025464 (6), 6308842 (4), 9546943 (1), 7664425 (1)
    depletion; potassium 6.37 5 7908173 (5)
    hypotensive 6.12 14 2853758 (2), 9773147 (1), 9374797 (1), 8921215 (1) (see all 13)
    disorder; panic 2.82 8 9885796 (3), 2160772 (2), 3037926 (1), 1989571 (1) (see all 5)
    syndrome tourette 2.77 6 12707939 (2), 8047638 (1), 18794646 (1), 18075481 (1) (see all 5)
    reading disabilities 2.73 3 16178932 (3)
    lesion; nerve 2.57 3 10050019 (2), 10342420 (1)
    inattention 2.39 3 16806103 (1), 1548248 (1), 12815749 (1)
    adrenocortical carcinoma 1.88 3 2547152 (3)
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    2 PharmGKB disease relationships for ADRA2A gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    HypertensionPD  9663918
    ObesityPD  12781566
    About this table

    Human Gene Mutation Database: ADRA2A
    Genetic Association Database: ADRA2A
    Human Genome Epidemiology Navigator: ADRA2A (81 documents)

    Medical News
    for ADRA2A gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for ADRA2A gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/352 PubMed articles for ADRA2A gene (see all 352 ):

    Search for ADRA2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ADRA2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150 HGNC: 281 AceView: ADRA2A Ensembl:ENSG00000150594 euGenes: HUgn150
    ECgene: ADRA2A Kegg: 150 H-InvDB: ADRA2A

    Other Databases showing ADRA2A gene

    (According to HUGE)
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    Specialized Databases showing ADRA2A gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    SeattleSNPshttp://pga.gs.washington.edu/data/adra2a/

    Intellectual Property
    for ADRA2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for ADRA2A gene: ""
    Search GeneIP for patents involving ADRA2A

    GeneCards and IP: ""
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    Services
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    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
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    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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