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Aliases for AZU1 Gene

Aliases for AZU1 Gene

  • Azurocidin 1 2 3
  • Heparin-Binding Protein 2 3 4
  • Cationic Antimicrobial Protein CAP37 3 4
  • Cationic Antimicrobial Protein 37 2 3
  • Neutrophil Azurocidin 2 3
  • CAP37 3 6
  • HBP 3 4
  • Azurocidin 3
  • HUMAZUR 3
  • AZAMP 3
  • NAZC 3
  • AZU 3

External Ids for AZU1 Gene

Previous GeneCards Identifiers for AZU1 Gene

  • GC19P000909
  • GC19P000765
  • GC19P000776
  • GC19P000597

Summaries for AZU1 Gene

Entrez Gene Summary for AZU1 Gene

  • Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Dec 2014]

GeneCards Summary for AZU1 Gene

AZU1 (Azurocidin 1) is a Protein Coding gene. Diseases associated with AZU1 include cornea cancer and erysipelas. GO annotations related to this gene include serine-type endopeptidase activity and toxic substance binding. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for AZU1 Gene

  • This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Gene Wiki entry for AZU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZU1 Gene

Genomics for AZU1 Gene

Regulatory Elements for AZU1 Gene

Transcription factor binding sites by QIAGEN in the AZU1 gene promoter:

Genomic Location for AZU1 Gene

Start:
825,097 bp from pter
End:
832,018 bp from pter
Size:
6,922 bases
Orientation:
Plus strand

Genomic View for AZU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AZU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZU1 Gene

Proteins for AZU1 Gene

  • Protein details for AZU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20160-CAP7_HUMAN
    Recommended name:
    Azurocidin
    Protein Accession:
    P20160
    Secondary Accessions:
    • P80014
    • Q52LG4
    • Q9UCM1
    • Q9UCT5

    Protein attributes for AZU1 Gene

    Size:
    251 amino acids
    Molecular mass:
    26886 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for AZU1 Gene

neXtProt entry for AZU1 Gene

Proteomics data for AZU1 Gene at MOPED

Post-translational modifications for AZU1 Gene

  • Glycosylation at Asn126, Asn140, and Asn171

Other Protein References for AZU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AZU1 Gene

Domains for AZU1 Gene

Suggested Antigen Peptide Sequences for AZU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20160

UniProtKB/Swiss-Prot:

CAP7_HUMAN :
  • P20160
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with AZU1: view

No data available for Gene Families for AZU1 Gene

Function for AZU1 Gene

Molecular function for AZU1 Gene

GENATLAS Biochemistry: azurocidin,37kDa,neutrophil and monocyte derived serine protease homolog,released from azurophilic granules of neutrophiles,oxygen independent phagocytes of Gram- bacteria
UniProtKB/Swiss-Prot Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Gene Ontology (GO) - Molecular Function for AZU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IBA --
GO:0008201 heparin binding NAS 11994286
GO:0015643 toxic substance binding NAS 10534120
genes like me logo Genes that share ontologies with AZU1: view

Phenotypes for AZU1 Gene

GenomeRNAi human phenotypes for AZU1:
genes like me logo Genes that share phenotypes with AZU1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AZU1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AZU1 Gene

Localization for AZU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZU1 Gene

Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AZU1 Gene COMPARTMENTS Subcellular localization image for AZU1 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AZU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11861296
GO:0042582 azurophil granule IDA 11861296
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AZU1: view

Pathways for AZU1 Gene

SuperPathways for AZU1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Interacting Proteins for AZU1 Gene

Gene Ontology (GO) - Biological Process for AZU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEP 12465046
GO:0006508 proteolysis --
GO:0006954 inflammatory response NAS 12678126
GO:0006955 immune response IBA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 12465046
genes like me logo Genes that share ontologies with AZU1: view

No data available for Pathways by source for AZU1 Gene

Compounds for AZU1 Gene

(1) HMDB Compounds for AZU1 Gene

Compound Synonyms Cas Number PubMed IDs
Heparin
  • Arteven
9005-49-6

(32) Novoseek inferred chemical compound relationships for AZU1 Gene

Compound -log(P) Hits PubMed IDs
heparin 84.6 138
heparan sulfate 78.7 7
dermatan sulfate 53.9 1
glycosaminoglycan 53.9 2
tinzaparin 49.3 1
genes like me logo Genes that share compounds with AZU1: view

Transcripts for AZU1 Gene

mRNA/cDNA for AZU1 Gene

Unigene Clusters for AZU1 Gene

Azurocidin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AZU1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AZU1 Gene

No ASD Table

Relevant External Links for AZU1 Gene

GeneLoc Exon Structure for
AZU1
ECgene alternative splicing isoforms for
AZU1

Expression for AZU1 Gene

mRNA expression in normal human tissues for AZU1 Gene

mRNA differential expression in normal tissues according to GTEx for AZU1 Gene

This gene is overexpressed in Whole Blood (43.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AZU1 Gene

SOURCE GeneReport for Unigene cluster for AZU1 Gene Hs.72885

genes like me logo Genes that share expressions with AZU1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AZU1 Gene

Orthologs for AZU1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for AZU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZU1 35
  • 98.27 (n)
  • 98.4 (a)
AZU1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AZU1 35
  • 79.18 (n)
  • 78.9 (a)
AZU1 36
  • 71 (a)
OneToOne
Species with no ortholog for AZU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AZU1 Gene

ENSEMBL:
Gene Tree for AZU1 (if available)
TreeFam:
Gene Tree for AZU1 (if available)

Paralogs for AZU1 Gene

Paralogs for AZU1 Gene

Selected SIMAP similar genes for AZU1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for AZU1 Gene

genes like me logo Genes that share paralogs with AZU1: view

Variants for AZU1 Gene

Sequence variations from dbSNP and Humsavar for AZU1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs588442 -- 831,811(+) TTCAC(C/T)CGAGT reference, synonymous-codon
rs595844 -- 830,854(+) AGGTT(C/T)GTCAA synonymous-codon, reference
rs606119 -- 827,655(+) GAGAG(A/G)GAAAC upstream-variant-2KB
rs618168 -- 828,059(+) GCGGA(C/T)GGTGT intron-variant
rs623697 -- 832,427(+) ATCAC(C/T)TGAAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AZU1 Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
nsv910260 CNV Loss 21882294
dgv3548n71 CNV Loss 21882294
dgv3549n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3551n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
dgv3553n71 CNV Loss 21882294
dgv3554n71 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv458321 CNV Loss 19166990
nsv910318 CNV Loss 21882294
dgv3558n71 CNV Loss 21882294
esv2717794 CNV Deletion 23290073
esv2668045 CNV Deletion 23128226
esv2743058 CNV Deletion 23290073
nsv910320 CNV Loss 21882294

Relevant External Links for AZU1 Gene

HapMap Linkage Disequilibrium report
AZU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZU1 Gene

Disorders for AZU1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for AZU1 Gene including...

Search for AZU1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for AZU1 Gene

(22) Novoseek inferred disease relationships for AZU1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 18.9 5
carcinoma embryonal 14.5 1
thrombocytopenia 11.6 2
response acute phase 6.8 3
diphtheria 3.82 1

Relevant External Links for AZU1

Genetic Association Database (GAD)
AZU1
Human Genome Epidemiology (HuGE) Navigator
AZU1
genes like me logo Genes that share disorders with AZU1: view

No data available for UniProtKB/Swiss-Prot for AZU1 Gene

Publications for AZU1 Gene

  1. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. (PMID: 1919011) Morgan J.G. … Larrick J.L. (J. Immunol. 1991) 2 3 4 23
  2. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. (PMID: 2049091) Almeida R.P. … Gabay J.E. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  3. Structure of HBP, a multifunctional protein with a serine proteinase fold. (PMID: 9095193) Iversen L.F. … Larsen I.K. (Nat. Struct. Biol. 1997) 3 4 23
  4. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PMID: 1518849) Zimmer M. … Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  5. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. (PMID: 1755383) Morgan J.G. … Larrick J.W. (Adv. Exp. Med. Biol. 1991) 3 4 23

Products for AZU1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AZU1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AZU1
    • Block miRNA regulation of AZU1 using miScript Target Protectors

    Sources for AZU1 Gene

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