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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AZU1 Gene

protein-coding   GIFtS: 56
GCID: GC19P000825

Azurocidin 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Azurocidin 11 2     CAP372 5
Heparin-Binding Protein1 2 3     AZAMP2
Cationic Antimicrobial Protein 371 2     AZU2
Neutrophil Azurocidin1 2     HUMAZUR2
Cationic Antimicrobial Protein CAP372 3     NAZC2
HBP2 3     azurocidin2

External Ids:    HGNC: 9131   Entrez Gene: 5662   Ensembl: ENSG000001722327   OMIM: 1628155   UniProtKB: P201603   

Export aliases for AZU1 gene to outside databases

Previous GC identifers: GC19P000909 GC19P000765 GC19P000776 GC19P000597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AZU1 Gene:
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the
killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with
monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator.
This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because
the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase
2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and
their protein products are packaged together into azurophil granules during neutrophil differentiation. (provided
by RefSeq, Jul 2008)

GeneCards Summary for AZU1 Gene: 
AZU1 (azurocidin 1) is a protein-coding gene. Diseases associated with AZU1 include cornea cancer, and erysipelas. GO annotations related to this gene include toxic substance binding and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic
glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this
specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged
lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in
mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the
Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does
not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532,
A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC
23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has
antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or
cathepsin G

Gene Wiki entry for AZU1 (Azurocidin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AZU1 gene promoter:
         AP-1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AZU1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AZU1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

AZU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZU1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000825:  view genomic region     (about GC identifiers)

Start:
825,097 bp from pter      End:
832,017 bp from pter
Size:
6,921 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160 (See protein sequence)
Recommended Name: Azurocidin precursor  
Size: 251 amino acids; 26886 Da
Subunit: Monomer
Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils
4 PDB 3D structures from and Proteopedia for AZU1:
1A7S (3D)        1AE5 (3D)        1FY1 (3D)        1FY3 (3D)    
Secondary accessions: P80014 Q52LG4 Q9UCM1 Q9UCT5

Explore the universe of human proteins at neXtProt for AZU1: NX_P20160

Explore proteomics data for AZU1 at MOPED 

AZU1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

AZU1 Protein Expression

REFSEQ proteins: NP_001691.1  
ENSEMBL proteins: 
 ENSP00000233997  

Human Recombinant Protein Products for AZU1: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for AZU1 (Azurocidin/CAP37/HBP)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for AZU1
OriGene Custom MassSpec 
OriGene Custom Protein Services for AZU1
GenScript Custom Purified and Recombinant Proteins Services for AZU1
Novus Biologicals AZU1 Protein
Novus Biologicals AZU1 Lysate
Sino Biological Recombinant Protein for AZU1
Sino Biological Cell Lysate for AZU1 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for AZU1 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS11861296
GO:0042582azurophil granule IDA11861296

AZU1 for ontologies           About GeneDecksing



AZU1 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for AZU1 (Azurocidin/CAP37/HBP)
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Abcam antibodies for AZU1
Cloud-Clone Corp. Antibodies for AZU1 
Search ThermoFisher Antibodies for AZU1
LSBio Antibodies in human, mouse, rat for AZU1 

Assay Products for AZU1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for AZU1
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GenScript Custom Assay Services for AZU1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for AZU1 
Cloud-Clone Corp. CLIAs for AZU1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR009003 Trypsin-like_Pept_dom
 IPR001254 Peptidase_S1

Graphical View of Domain Structure for InterPro Entry P20160

ProtoNet protein and cluster: P20160

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


AZU1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CAP7_HUMAN, P20160
Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic
glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this
specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged
lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in
mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the
Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does
not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532,
A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC
23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has
antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or
cathepsin G

     Genatlas biochemistry entry for AZU1:
azurocidin,37kDa,neutrophil and monocyte derived serine protease homolog,released from azurophilic granules of
neutrophiles,oxygen independent phagocytes of Gram- bacteria

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0008201heparin binding NAS11994286
GO:0015643toxic substance binding NAS10534120
     
AZU1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for AZU1:
 Decreased Salmonella enterica  

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for AZU1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AZU1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AZU1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AZU1 

miRNA
Products:
    
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AZU1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for AZU1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZU1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for AZU1
Sirion Biotech Customized adenovirus for overexpression of AZU1

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for AZU1 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AZU1 (NM_001700)
Sino Biological Human cDNA Clone for AZU1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZU1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AZU1
Sirion Biotech Customized lentivirus for stable overexpression of AZU1 
                     Customized lentivirus expression plasmids for stable overexpression of AZU1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for AZU1
Search LifeMap BioReagents cell lines for AZU1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZU1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AZU1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/37 Interacting proteins for AZU1 (P201602, 3 ENSP000002339974) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
InteractantInteraction Details
GeneCardExternal ID(s)
CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
TTKP339813, ENSP000002305104I2D: score=2 STRING: ENSP00000230510
ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
ELANEP082463I2D: score=1 
A2MP010232MINT-4054731
About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001774microglial cell activation IEP12465046
GO:0006508proteolysis IEA--
GO:0006954inflammatory response NAS12678126
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway TAS12465046
GO:0008347glial cell migration IDA12465046

AZU1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AZU1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AZU1 (CAP7)

1 HMDB Compound for AZU1    About this table
CompoundSynonyms CAS #PubMed Ids
HeparinArteven (see all 17)9005-49-6--

10/32 Novoseek inferred chemical compound relationships for AZU1 gene (see all 32)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 84.6 271 9544807 (4), 1699446 (4), 9177698 (4), 16314105 (4) (see all 99)
heparan sulfate 78.7 8 1387642 (1), 8662616 (1), 18343110 (1), 12491369 (1) (see all 7)
dermatan sulfate 53.9 2 14588099 (1)
glycosaminoglycan 53.9 2 8195298 (1), 16712822 (1)
tinzaparin 49.3 1 12166042 (1)
protamine sulfate 48.7 1 11801647 (1)
chondroitin sulfate 48.3 1 19389385 (1)
serine 42.5 25 1518849 (2), 2332502 (2), 1919011 (2), 2049091 (1) (see all 11)
fucoidan 33.7 3 9826363 (3)
polysaccharide 23.4 1 10548047 (1)

Search CenterWatch for drugs/clinical trials and news about AZU1 / CAP7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AZU1 gene: 
NM_001700.3  

Unigene Cluster for AZU1:

Azurocidin 1
Hs.72885  [show with all ESTs]
Unigene Representative Sequence: BC044940
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000592205 ENST00000233997(uc002lpz.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AZU1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AZU1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for AZU1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZU1
Clone
Products:
     
OriGene clones in human, mouse for AZU1 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: AZU1 (NM_001700)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZU1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AZU1
Sirion Biotech Customized lentivirus for stable overexpression of AZU1 
                     Customized lentivirus expression plasmids for stable overexpression of AZU1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for AZU1
OriGene qSTAR qPCR primer pairs in human, mouse for AZU1
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AZU1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZU1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZU1

Additional mRNA sequence: 

BC044940.1 BC069495.1 BC093931.1 BC093933.1 X58794.1 

3 DOTS entries:

DT.409983  DT.95157270  DT.91826897 

24/34 AceView cDNA sequences (see all 34):

BC069495 BI031057 NM_001700 BU617927 BI770059 X58794 T28021 BQ447054 
BP430543 BI029207 BC044940 AJ705649 AW075790 BI022268 AA505389 AW467282 
AA456322 AA702802 BQ335848 BF903310 BI022758 BI026721 AW195252 AW467266 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AZU1 expression in normal human tissues (normalized intensities)      AZU1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
AZU1 Expression
About this image


AZU1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 7 entries
         Bone marrow-derived hematopoietic stem cells
         Bone Marrow CD34+ Cells   
         bone marrow mononuclear cells   
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Bone Marrow
         bone marrow   
 
 Liver (Hepatobiliary System)
         Fetal Liver CD34+ Cells   

See AZU1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AZU1

SOURCE GeneReport for Unigene cluster: Hs.72885
    SABiosciences Expression via Pathway-Focused PCR Arrays including AZU1: 
          Apoptosis 384HT in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for AZU1
OriGene qSTAR qPCR primer pairs in human, mouse for AZU1
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AZU1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZU1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZU1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZU1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AZU1 gene from 3/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
cow
(Bos taurus)
Mammalia AZU11 azurocidin 1 80.68(n)
80.41(a)
  100336938  XM_002689142.1  XP_002689188.1 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-78l4.46
si:dkey-78l4.136
(see all 25)
si:dkey-78l4.13
(see all 25)
33(a)
32(a)
(see all 25)
possible ortholog
possible ortholog
(see all 25)
22(19733409-19736079)
22(19841769-19848393)
fruit fly
(Drosophila melanogaster)
Insecta CG328086
CG167496
(see all 3)
--
26(a)
23(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
X(1362763-1363679)
3R(5156607-5157617)


ENSEMBL Gene Tree for AZU1 (if available)
TreeFam Gene Tree for AZU1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for AZU1 gene
GZMH2  PRTN32  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  
GZMM2  GZMA2  GZMB2  
18/27 SIMAP similar genes for AZU1 using alignment to 2 protein entries:     CAP7_HUMAN (see all proteins) (see all similar genes):
PRTN3    ELA2    ELANE    GZMH    PRSSL1    GZMB
APS    KLK3    CTSG    GZMK    KLK2    LPA
PRSS57    GZMA    GZMM    KLK11    KLK12    KLK14

AZU1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for AZU1
PGOHUM00000248374


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/252 SNPs in AZU1 are shown (see all 252)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1388973261,2
--825862(+) TTGGAC/TGCAGT 1 -- us2k10--------
rs1127564591,2
C,F--825894(+) CACTTC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs286315971,2
C,F--826044(+) GAGGCG/AGGAGG 1 -- us2k13Minor allele frequency- A:0.40NA CSA 5
rs1378998171,2
--826077(+) AGGCTG/TCAGCG 1 -- us2k10--------
rs1814636041,2
--826116(+) CTGGGA/CAACAT 1 -- us2k10--------
rs1114715791,2
C,F--826118(+) GGGCAC/ACATAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1505244371,2
C--826160(+) TTAGCC/TGGGCA 1 -- us2k10--------
rs1839098161,2
--826173(+) GTGGCA/GGGTGC 1 -- us2k10--------
rs1118330051,2
C,F--826248(+) GCAGTG/TAGCTG 1 -- us2k13Minor allele frequency- T:0.22WA CSA 122
rs1890815741,2
--826293(+) CGAGAC/TCTCAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for AZU1 (825097 - 832017 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/23 variations for AZU1 (see all 23):    About this table     
Variant IDTypeSubtypePubMed ID
esv2717794CNV Deletion23290073
esv2668045CNV Deletion23128226
esv2743058CNV Deletion23290073
nsv470101CNV Loss18288195
dgv3550n71CNV Loss21882294
nsv910292CNV Loss21882294
dgv3548n71CNV Loss21882294
dgv3558n71CNV Loss21882294
dgv3555n71CNV Loss21882294
dgv3552n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 162815    OMIM disorders: --

20/30 diseases for AZU1 (see all 30):    About MalaCards
cornea cancer    erysipelas    heparin-induced thrombocytopenia    ovarian hyperstimulation syndrome
peritonitis    thrombocytopenia    duchenne muscular dystrophy    diphtheria
biliary atresia    epididymitis    vasculitis    thrombosis
thromboembolism    diabetic retinopathy    muscular dystrophy    nephritis
alzheimer's disease    herpes simplex    glomerulonephritis    endometriosis

1 disease from the University of Copenhagen DISEASES database for AZU1:
Cornea cancer

AZU1 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/22 Novoseek inferred disease relationships for AZU1 gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 18.9 6 2332502 (2), 11590435 (1), 11170199 (1), 11980855 (1)
carcinoma embryonal 14.5 1 2229028 (1)
thrombocytopenia 11.6 2 9372019 (1), 8833886 (1)
response acute phase 6.8 4 9301637 (3)
diphtheria 3.82 1 11284691 (1)
cancer 3.67 1 19002078 (1)
tumors 2.34 15 1987767 (1), 16519745 (1), 19754371 (1), 11980855 (1) (see all 11)
edema 1.63 2 19477593 (1)
thrombosis 0.786 2 9372019 (1), 8833886 (1)
carcinoma squamous cell 0 1 1885605 (1)

Genetic Association Database (GAD): AZU1
Human Genome Epidemiology (HuGE) Navigator: AZU1 (3 documents)

Export disorders for AZU1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for AZU1 gene, integrated from 9 sources (see all 252):
(articles sorted by number of sources associating them with AZU1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. (PubMed id 1919011)1, 2, 3, 9 Morgan J.G.... Larrick J.L. (1991)
  2. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. (PubMed id 2332502)1, 2, 9 Pereira H.A.... Spitznagel J.K. (1990)
  3. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (1992)
  4. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. (PubMed id 8506327)1, 2, 9 Pereira H.A.... Spitznagel J.K. (1993)
  5. Atomic resolution structure of human HBP/CAP37/azurocidin. (PubMed id 9761855)1, 2, 9 Karlsen S.... Kastrup J.S. (1998)
  6. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. (PubMed id 1755383)1, 2, 9 Morgan J.G....Larrick J.W. (1991)
  7. Structure of HBP, a multifunctional protein with a serine proteinase fold. (PubMed id 9095193)1, 2, 9 Iversen L.F.... Larsen I.K. (1997)
  8. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. (PubMed id 2049091)1, 2, 9 Almeida R.P.... Gabay J.E. (1991)
  9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
  10. Postural changes in blood pressure associated with in teractions between candidate genes for chronic respiratory diseases and exposur e to particulate matter. (PubMed id 19590686)1, 4 Wilker E....Schwartz J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 566 HGNC: 913 AceView: AZU1 Ensembl:ENSG00000172232 euGenes: HUgn566
ECgene: AZU1 H-InvDB: AZU1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for AZU1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for AZU1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for AZU1 gene:
Search GeneIP for patents involving AZU1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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