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AZU1 Gene

protein-coding   GIFtS: 57
GCID: GC19P000825

Azurocidin 1

  See AZU1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Azurocidin 11 2     CAP372 5
Heparin-Binding Protein1 2 3     AZAMP2
Cationic Antimicrobial Protein 371 2     AZU2
Neutrophil Azurocidin1 2     HUMAZUR2
Cationic Antimicrobial Protein CAP372 3     NAZC2
HBP2 3     azurocidin2

External Ids:    HGNC: 9131   Entrez Gene: 5662   Ensembl: ENSG000001722327   OMIM: 1628155   UniProtKB: P201603   

Export aliases for AZU1 gene to outside databases

Previous GC identifers: GC19P000909 GC19P000765 GC19P000776 GC19P000597


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AZU1 Gene:
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the
killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with
monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator.
This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because
the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase
2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and
their protein products are packaged together into azurophil granules during neutrophil differentiation. (provided
by RefSeq, Jul 2008)

GeneCards Summary for AZU1 Gene:
AZU1 (azurocidin 1) is a protein-coding gene. Diseases associated with AZU1 include cornea cancer, and erysipelas. GO annotations related to this gene include toxic substance binding and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic
glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this
specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged
lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in
mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the
Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does
not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532,
A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC
23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has
antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or
cathepsin G

Gene Wiki entry for AZU1 (Azurocidin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  NT_187622.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the AZU1 gene promoter:
         AP-1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AZU1 promoter sequence
   Search Chromatin IP Primers for AZU1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AZU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

AZU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZU1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000825:  view genomic region     (about GC identifiers)

Start:
825,097 bp from pter      End:
832,017 bp from pter
Size:
6,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160 (See protein sequence)
Recommended Name: Azurocidin precursor  
Size: 251 amino acids; 26886 Da
Subunit: Monomer
4 PDB 3D structures from and Proteopedia for AZU1:
1A7S (3D)        1AE5 (3D)        1FY1 (3D)        1FY3 (3D)    
Secondary accessions: P80014 Q52LG4 Q9UCM1 Q9UCT5

Explore the universe of human proteins at neXtProt for AZU1: NX_P20160

Explore proteomics data for AZU1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn126, Asn140, Asn171

  • See AZU1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001691.1  
    ENSEMBL proteins: 
     ENSP00000233997  

    AZU1 Human Recombinant Protein Products:

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    antibodies-online proteins for AZU1 (12 products) 

     
    antibodies-online peptides for AZU1

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    antibodies-online antibodies for AZU1 (36 products) 

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    antibodies-online kits for AZU1 (32 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P20160

    ProtoNet protein and cluster: P20160

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with AZU1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAP7_HUMAN, P20160
    Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic
    glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this
    specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged
    lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in
    mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the
    Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does
    not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532,
    A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC
    23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has
    antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or
    cathepsin G

         Genatlas biochemistry entry for AZU1:
    azurocidin,37kDa,neutrophil and monocyte derived serine protease homolog,released from azurophilic granules of
    neutrophiles,oxygen independent phagocytes of Gram- bacteria

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252NOT serine-type endopeptidase activity IBA--
    GO:0008201heparin binding NAS11994286
    GO:0015643toxic substance binding NAS10534120
         
    Find genes that share ontologies with AZU1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AZU1:
     Decreased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AZU1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAP7_HUMAN, P20160: Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    vacuole5
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11861296
    GO:0042582azurophil granule IDA11861296
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with AZU1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including AZU1: 
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AZU1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for AZU1 (P201602, 3 ENSP000002339974) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    TTKP339813, ENSP000002305104I2D: score=2 STRING: ENSP00000230510
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    ELANEP082463I2D: score=1 
    A2MP010232MINT-4054731
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001774microglial cell activation IEP12465046
    GO:0006508proteolysis IBA--
    GO:0006954inflammatory response NAS12678126
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway TAS12465046
    GO:0008347glial cell migration IDA12465046

    Find genes that share ontologies with AZU1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AZU1 (CAP7)

    1 HMDB Compound for AZU1    About this table
    CompoundSynonyms CAS #PubMed Ids
    HeparinArteven (see all 17)9005-49-6--

    Selected Novoseek inferred chemical compound relationships for AZU1 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 84.6 271 9544807 (4), 1699446 (4), 9177698 (4), 16314105 (4) (see all 99)
    heparan sulfate 78.7 8 1387642 (1), 8662616 (1), 18343110 (1), 12491369 (1) (see all 7)
    dermatan sulfate 53.9 2 14588099 (1)
    glycosaminoglycan 53.9 2 8195298 (1), 16712822 (1)
    tinzaparin 49.3 1 12166042 (1)
    protamine sulfate 48.7 1 11801647 (1)
    chondroitin sulfate 48.3 1 19389385 (1)
    serine 42.5 25 1518849 (2), 2332502 (2), 1919011 (2), 2049091 (1) (see all 11)
    fucoidan 33.7 3 9826363 (3)
    polysaccharide 23.4 1 10548047 (1)



    Find genes that share compounds with AZU1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AZU1 gene: 
    NM_001700.3  

    Unigene Cluster for AZU1:

    Azurocidin 1
    Hs.72885  [show with all ESTs]
    Unigene Representative Sequence: BC044940
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592205 ENST00000233997(uc002lpz.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat AZU1
      QuantiFast Probe-based Assays in human, mouse, rat AZU1

    Additional mRNA sequence: 

    BC044940.1 BC069495.1 BC093931.1 BC093933.1 X58794.1 

    3 DOTS entries:

    DT.409983  DT.95157270  DT.91826897 

    Selected AceView cDNA sequences (see all 34):

    NM_001700 BC069495 BU617927 BI031057 X58794 BP430543 BI029207 T28021 
    BI770059 BQ447054 BC044940 AA505389 BI022268 AJ705649 AW075790 AA702802 
    AW467282 AA456322 BF903310 BQ335848 AW195252 BI022758 BI026721 BQ335269 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AZU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AZU1 Expression
    About this image


    AZU1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Bone marrow-derived hematopoietic stem cells (family)
             Bone Marrow CD34+ Cells   
             bone marrow mononuclear cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
    AZU1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AZU1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72885
        Pathway & Disease-focused RT2 Profiler PCR Arrays including AZU1: 
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for AZU1 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia AZU11 azurocidin 1 79.18(n)
    78.9(a)
      100336938  XM_005209322.1  XP_005209379.1 


    ENSEMBL Gene Tree for AZU1 (if available)
    TreeFam Gene Tree for AZU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AZU1 gene
    GZMH2  PRTN32  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  
    GZMM2  GZMA2  GZMB2  
    Selected SIMAP similar genes for AZU1 using alignment to 2 protein entries:     CAP7_HUMAN (see all proteins) (see all similar genes):
    PRTN3    ELA2    ELANE    GZMH    PRSSL1    GZMB
    APS    KLK3    CTSG    GZMK    KLK2    LPA
    PRSS57    GZMM    GZMA    KLK11    KLK12    KLK14

    Find genes that share paralogs with AZU1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for AZU1
    PGOHUM00000248374


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AZU1 (see all 252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388973261,2
    --825862(+) TTGGAC/TGCAGT 1 -- us2k10--------
    rs1127564591,2
    C,F--825894(+) CACTTC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs286315971,2
    C,F--826044(+) GAGGCG/AGGAGG 1 -- us2k13Minor allele frequency- A:0.40NA CSA 5
    rs1378998171,2
    --826077(+) AGGCTG/TCAGCG 1 -- us2k10--------
    rs1814636041,2
    --826116(+) CTGGGA/CAACAT 1 -- us2k10--------
    rs1114715791,2
    C,F--826118(+) GGGCAC/ACATAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1505244371,2
    C--826160(+) TTAGCC/TGGGCA 1 -- us2k10--------
    rs1839098161,2
    --826173(+) GTGGCA/GGGTGC 1 -- us2k10--------
    rs1118330051,2
    C,F--826248(+) GCAGTG/TAGCTG 1 -- us2k13Minor allele frequency- T:0.22WA CSA 122
    rs1890815741,2
    --826293(+) CGAGAC/TCTCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AZU1 (825097 - 832017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AZU1 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717794CNV Deletion23290073
    esv2668045CNV Deletion23128226
    esv2743058CNV Deletion23290073
    nsv470101CNV Loss18288195
    dgv3550n71CNV Loss21882294
    nsv910292CNV Loss21882294
    dgv3548n71CNV Loss21882294
    dgv3558n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3552n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AZU1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162815    OMIM disorders: --

    3 diseases for AZU1:    
    About MalaCards
    cornea cancer    erysipelas    burns

    1 disease from the University of Copenhagen DISEASES database for AZU1:
    Cornea cancer

    Find genes that share disorders with AZU1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AZU1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 18.9 6 2332502 (2), 11590435 (1), 11170199 (1), 11980855 (1)
    carcinoma embryonal 14.5 1 2229028 (1)
    thrombocytopenia 11.6 2 9372019 (1), 8833886 (1)
    response acute phase 6.8 4 9301637 (3)
    diphtheria 3.82 1 11284691 (1)
    cancer 3.67 1 19002078 (1)
    tumors 2.34 15 1987767 (1), 16519745 (1), 19754371 (1), 11980855 (1) (see all 11)
    edema 1.63 2 19477593 (1)
    thrombosis 0.786 2 9372019 (1), 8833886 (1)
    carcinoma squamous cell 0 1 1885605 (1)

    Genetic Association Database (GAD): AZU1
    Human Genome Epidemiology (HuGE) Navigator: AZU1 (3 documents)

    Export disorders for AZU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AZU1 gene, integrated from 10 sources (see all 253):
    (articles sorted by number of sources associating them with AZU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. (PubMed id 1919011)1, 2, 3, 9 Morgan J.G.... Larrick J.L. (J. Immunol. 1991)
    2. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. (PubMed id 2332502)1, 2, 9 Pereira H.A.... Spitznagel J.K. (J. Clin. Invest. 1990)
    3. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    4. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. (PubMed id 8506327)1, 2, 9 Pereira H.A.... Spitznagel J.K. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    5. Atomic resolution structure of human HBP/CAP37/azurocidin. (PubMed id 9761855)1, 2, 9 Karlsen S.... Kastrup J.S. (Acta Crystallogr. D 1998)
    6. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. (PubMed id 1755383)1, 2, 9 Morgan J.G....Larrick J.W. (Adv. Exp. Med. Biol. 1991)
    7. Structure of HBP, a multifunctional protein with a serine proteinase fold. (PubMed id 9095193)1, 2, 9 Iversen L.F.... Larsen I.K. (Nat. Struct. Biol. 1997)
    8. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. (PubMed id 2049091)1, 2, 9 Almeida R.P.... Gabay J.E. (Biochem. Biophys. Res. Commun. 1991)
    9. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    10. Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. (PubMed id 19590686)1, 4 Wilker E....Schwartz J. (Environ. Health Perspect. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 566 HGNC: 913 AceView: AZU1 Ensembl:ENSG00000172232 euGenes: HUgn566
    ECgene: AZU1 H-InvDB: AZU1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AZU1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AZU1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AZU1 gene:
    Search GeneIP for patents involving AZU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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