Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AZU1 Gene

protein-coding   GIFtS: 54
GCID: GC19P000825

azurocidin 1

 Explore 30 diseases affiliated with
AZU1 via our new
 Human Malady Compendium 
Biological research products
for AZU1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Azurocidin 11 2     NAZC1 2
HBP1 2 3     Cationic Antimicrobial Protein CAP372 3
CAP371 2 5     Heparin-Binding Protein2 3
AZAMP1 2     Azurocidin1
AZU1 2     Cationic Antimicrobial Protein 372
HUMAZUR1 2     Neutrophil Azurocidin2

External Ids:    HGNC: 9131   Entrez Gene: 5662   Ensembl: ENSG000001722327   OMIM: 1628155   UniProtKB: P201603   

Export aliases for AZU1 gene to outside databases

Previous GC identifers: GC19P000909 GC19P000765 GC19P000776 GC19P000597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AZU1:
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of
microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic
and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a
member of the serine protease gene family but it is not a serine proteinase, because the active site serine and
histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a
cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged
together into azurophil granules during neutrophil differentiation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic
glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this
specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged
lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating
recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative
bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have
antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans
NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123,
Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against
C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G

Gene Wiki entry for AZU1 (Azurocidin 1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AZU1 gene promoter:
         AP-1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AZU1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AZU1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

AZU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZU1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000825:  view genomic region     (about GC identifiers)

Start:
825,097 bp from pter      End:
832,017 bp from pter
Size:
6,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160 (See protein sequence)
Recommended Name: Azurocidin precursor  
Size: 251 amino acids; 26886 Da
Subunit: Monomer
Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils
4 PDB 3D structures from and Proteopedia for AZU1:
1A7S (3D)        1AE5 (3D)        1FY1 (3D)        1FY3 (3D)    
Secondary accessions: P80014 Q52LG4 Q9UCM1 Q9UCT5

Explore the universe of human proteins at neXtProt for AZU1: NX_P20160

AZU1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_001691.1  
ENSEMBL proteins: 
 ENSP00000233997  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for AZU1 (Azurocidin/CAP37/HBP)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: AZU1
OriGene Custom Protein Services for AZU1 
GenScript Custom Purified and Recombinant Proteins Services for AZU1
Novus Biologicals AZU1 Protein
Novus Biologicals AZU1 Lysate
Sino Biological Recombinant Protein for AZU1
Browse ProSpec Recombinant Proteins
Uscn Proteins for AZU1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS11861296
GO:0042582azurophil granule IDA11861296


AZU1 for ontologies           About GeneDecksing



AZU1 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for AZU1 (Azurocidin/CAP37/HBP)
Browse OriGene Antibodies
OriGene Custom Antibody Services for AZU1 
GenScript Custom Superior Antibodies Services for AZU1
Novus Biologicals AZU1 Antibodies
Search for Antibodies for AZU1 at Abcam  
Uscn Antibodies for AZU1
Search ThermoFisher Antibodies for AZU1

Assay Products for AZU1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for AZU1
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for AZU1


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AZU1 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR001314 Peptidase_S1A
 IPR009003 Trypsin-like_Pept_dom
 IPR001254 Peptidase_S1

Graphical View of Domain Structure for InterPro Entry P20160

ProtoNet protein and cluster: P20160

2 Blocks protein families:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: CAP7_HUMAN, P20160
Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic
glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this
specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged
lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating
recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative
bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have
antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans
NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123,
Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against
C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G

     Genatlas biochemistry entry for AZU1:
azurocidin,37kDa,neutrophil and monocyte derived serine protease homolog,released from azurophilic granules of
neutrophiles,oxygen independent phagocytes of Gram- bacteria

miRNA
Products:
    
OriGene 3'-UTR Clone: AZU1
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AZU1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AZU1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AZU1
OriGene shRNA RFP: AZU1
OriGene siRNA: AZU1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZU1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for AZU1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AZU1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AZU1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: AZU1 (NM_001700)
Sino Biological Human cDNA Clone for AZU1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZU1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AZU1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for AZU1
Search LifeMap BioReagents cell lines for AZU1

In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for AZU1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004252serine-type endopeptidase activity IEA--
GO:0008201heparin binding NAS11994286
GO:0015643toxin binding NAS10534120


AZU1 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for AZU1:
 Decreased Salmonella enterica  


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AZU1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/37 Interacting proteins for AZU1 (P201602, 3 ENSP000002339974) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
InteractantInteraction Details
GeneCardExternal ID(s)
CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
TTKP339813, ENSP000002305104I2D: score=2 STRING: ENSP00000230510
ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
ELANEP082463I2D: score=1 
A2MP010232MINT-4054731
About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001774microglial cell activation IEP12465046
GO:0006508proteolysis IEA--
GO:0006954inflammatory response NAS12678126
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway TAS12465046
GO:0008347glial cell migration IDA12465046


AZU1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AZU1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AZU1

1 HMDB Compound for AZU1    About this table
CompoundSynonyms CAS #PubMed Ids
HeparinArteven (see all 17)9005-49-6--
10/32 Novoseek chemical compound relationships for AZU1 gene (see all 32)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 84.6 271 9544807 (4), 1699446 (4), 9177698 (4), 16314105 (4) (see all 99)
heparan sulfate 78.7 8 1387642 (1), 8662616 (1), 18343110 (1), 12491369 (1) (see all 7)
dermatan sulfate 53.9 2 14588099 (1)
glycosaminoglycan 53.9 2 8195298 (1), 16712822 (1)
tinzaparin 49.3 1 12166042 (1)
protamine sulfate 48.7 1 11801647 (1)
chondroitin sulfate 48.3 1 19389385 (1)
serine 42.5 25 1518849 (2), 2332502 (2), 1919011 (2), 2049091 (1) (see all 11)
fucoidan 33.7 3 9826363 (3)
polysaccharide 23.4 1 10548047 (1)

Search CenterWatch for drugs/clinical trials and news about AZU1 / CAP7 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AZU1 gene: 
NM_001700.3  

Unigene Cluster for AZU1:

Azurocidin 1
Hs.72885  [show with all ESTs]
Unigene Representative Sequence: BC044940
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000592205 ENST00000233997(uc002lpz.1)

miRNA
Products:
     
OriGene 3'-UTR Clone: AZU1
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AZU1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AZU1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AZU1
OriGene shRNA RFP: AZU1
OriGene siRNA: AZU1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZU1
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AZU1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AZU1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: AZU1 (NM_001700)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZU1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AZU1 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AZU1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AZU1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZU1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZU1

Additional cDNA sequence: 

BC044940.1 BC069495.1 BC093931.1 BC093933.1 X58794.1 

3 DOTS entries:

DT.409983  DT.95157270  DT.91826897 

24/34 AceView cDNA sequences (see all 34):

NM_001700 BU617927 BC069495 BI031057 T28021 X58794 BP430543 BI770059 
BI029207 BC044940 BQ447054 BI022268 AA505389 AJ705649 AW075790 AA456322 
AA702802 AW467282 BQ335848 BF903310 BQ335269 AW467266 AW195252 BI026721 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AZU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See AZU1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AZU1

SOURCE GeneReport for Unigene cluster: Hs.72885
    SABiosciences Expression via Pathway-Focused PCR Arrays including AZU1: 
          Apoptosis 384HT in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AZU1
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AZU1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZU1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZU1
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for AZU1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AZU1 gene from 2/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
zebrafish
(Danio rerio)
Actinopterygii CR558302.26
AL954146.16
--
26(a)
25(a)
possible ortholog
possible ortholog
11(3640652-3646662)
23(37542555-37552094)
fruit fly
(Drosophila melanogaster)
Insecta CG111926
Try29F6
(see all 49)
Trypsin 29F
(see all 49)
28(a)
27(a)
(see all 49)
possible ortholog
possible ortholog
(see all 49)
2R(16241610-16242558)
2L(8998537-8999468)


ENSEMBL Gene Tree for AZU1 (if available)
TreeFam Gene Tree for AZU1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for AZU1 gene
PRTN32  GZMH2  GZMK2  PRSS572  CTSG2  CFD2  ELANE2  CMA12  
GZMM2  GZMA2  GZMB2  
18/38 SIMAP similar genes for AZU1 using alignment to 2 protein entries:     CAP7_HUMAN (see all proteins) (see all similar genes):
PRTN3    ELA2    ELANE    GZMH    PRSSL1    GZMB
APS    KLK3    CTSG    GZMK    KLK2    LPA
PRSS57    GZMA    GZMM    KLK11    KLK12    KLK14

AZU1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for AZU1
PGOHUM00000248374


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/187 NCBI SNPs in AZU1 are shown (see all 187    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1388973261,2
--825862(+) TTGGAC/TGCAGT 1 -- us2k10--------
rs1127564591,2
C,--825894(+) CACTTC/TGGGAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs286315971,2
C,F,--826044(+) GAGGCG/AGGAGG 1 -- us2k13Minor allele frequency- A:0.40NA CSA 5
rs1378998171,2
--826077(+) AGGCTG/TCAGCG 1 -- us2k10--------
rs1814636041,2
--826116(+) CTGGGA/CAACAT 1 -- us2k10--------
rs1114715791,2
C,--826118(+) GGGCAC/ACATAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1505244371,2
--826160(+) TTAGCC/TGGGCA 1 -- us2k10--------
rs1839098161,2
--826173(+) GTGGCA/GGGTGC 1 -- us2k10--------
rs1118330051,2
C,F,--826248(+) GCAGTG/TAGCTG 1 -- us2k13Minor allele frequency- T:0.22WA CSA 122
rs1890815741,2
--826293(+) CGAGAC/TCTCAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for AZU1 (825097 - 832017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AZU1
     1 CNV: 30052

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AZU1
DNA2.0 Custom Variant and Variant Library Synthesis for AZU1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AZU1 for disorders           About GeneDecksing

OMIM gene information: 162815    OMIM disorders: --

20/30 diseases for AZU1 (see all 30):    About MalaCards
heparin-induced thrombocytopenia    duchenne muscular dystrophy    muscular dystrophy    ovarian hyperstimulation syndrome
biliary atresia    erysipelas    diphtheria    thrombocytopenia
herpes simplex    diabetic retinopathy    thrombosis    embryonal carcinoma
alzheimer's disease    epididymitis    peritonitis    sepsis
vasculitis    nephritis    ovarian carcinoma    endometriosis

1 disease from the University of Copenhagen DISEASES database for AZU1:
Cornea cancer

10/22 Novoseek disease relationships for AZU1 gene (see all 22)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 18.9 6 2332502 (2), 11590435 (1), 11170199 (1), 11980855 (1)
carcinoma embryonal 14.5 1 2229028 (1)
thrombocytopenia 11.6 2 9372019 (1), 8833886 (1)
response acute phase 6.8 4 9301637 (3)
diphtheria 3.82 1 11284691 (1)
cancer 3.67 1 19002078 (1)
tumors 2.34 15 1987767 (1), 16519745 (1), 19754371 (1), 11980855 (1) (see all 11)
edema 1.63 2 19477593 (1)
thrombosis 0.786 2 9372019 (1), 8833886 (1)
carcinoma squamous cell 0 1 1885605 (1)

Human Genome Epidemiology (HuGE) Navigator: AZU1 (3 documents)

Export disorders for AZU1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for AZU1 gene, integrated from 9 sources (see all 252):
(articles sorted by number of sources associating them with AZU1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. (PubMed id 1919011)1, 2, 3, 9 Morgan J.G.... Larrick J.L. (1991)
  2. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. (PubMed id 2332502)1, 2, 9 Pereira H.A.... Spitznagel J.K. (1990)
  3. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. (PubMed id 1518849)1, 2, 9 Zimmer M....Jenne D.E. (1992)
  4. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. (PubMed id 8506327)1, 2, 9 Pereira H.A.... Spitznagel J.K. (1993)
  5. Atomic resolution structure of human HBP/CAP37/azurocidin. (PubMed id 9761855)1, 2, 9 Karlsen S.... Kastrup J.S. (1998)
  6. Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. (PubMed id 1755383)1, 2, 9 Morgan J.G....Larrick J.W. (1991)
  7. Structure of HBP, a multifunctional protein with a serine proteinase fold. (PubMed id 9095193)1, 2, 9 Iversen L.F.... Larsen I.K. (1997)
  8. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. (PubMed id 2049091)1, 2, 9 Almeida R.P.... Gabay J.E. (1991)
  9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 566 HGNC: 913 AceView: AZU1 Ensembl:ENSG00000172232 euGenes: HUgn566
ECgene: AZU1 H-InvDB: AZU1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for AZU1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for AZU1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for AZU1 gene:
Search GeneIP for patents involving AZU1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for AZU1 (Azurocidin/CAP37/HBP)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for AZU1 (Azurocidin/CAP37/HBP)  
 Browse OriGene Antibodies   OriGene shRNA RFP for AZU1  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AZU1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AZU1  
 OriGene Protein Over-expression Lysate for AZU1   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for AZU1   OriGene 3'-UTR Clone for AZU1  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AZU1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AZU1  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for AZU1   OriGene Custom Protein Services for AZU1  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AZU1
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AZU1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZU1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZU1
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZU1
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZU1
 GenScript Custom Purified and Recombinant Proteins Services for AZU1 GenScript cDNA clones with any tag delivered in your preferred vector for AZU1
 GenScript Custom Assay Services for AZU1 GenScript Custom Superior Antibodies Services for AZU1
 GenScript Custom overexpressing Cell Line Services for AZU1 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in AZU1 promoter
 Search Chromatin IP Primers for AZU1
 RT2 qPCR Primer Assay in human, mouse / rat AZU1
 GNC Network for AZU1
 SABiosciences PCR Arrays including human, mouse / rat AZU1
 Search Tocris compounds for AZU1
 Proteins and Antibodies for AZU1
 cDNA Clones for AZU1
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 AZU1 antibodies
 AZU1 proteins
 AZU1 lysates
 Search for Antibodies for AZU1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for AZU1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 AZU1 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for AZU1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for AZU1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for AZU1
 SwitchGear Promoter luciferase reporter plasmids for AZU1
 Search ThermoFisher Antibodies for AZU1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AZU1
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      AZU1 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4