Aliases for AZIN2 Gene
Aliases for AZIN2 Gene
External Ids for AZIN2 Gene
- HGNC: 29957
- Entrez Gene: 113451
- Ensembl: ENSG00000142920
- OMIM: 608353
- UniProtKB: Q96A70
Previous HGNC Symbols for AZIN2 Gene
- ADC
Summaries for AZIN2 Gene
-
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
GeneCards Summary for AZIN2 Gene
AZIN2 (Antizyme Inhibitor 2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Arginine and proline metabolism. GO annotations related to this gene include ornithine decarboxylase activity and putrescine transmembrane transporter activity. An important paralog of this gene is ODC1.
UniProtKB/Swiss-Prot for AZIN2 Gene
-
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZIN2 Gene
Genomics for AZIN2 Gene
Regulatory Elements for AZIN2 Gene
Enhancers for AZIN2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AZIN2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for AZIN2 Gene
- Chromosome:
- 1
- Start:
- 33,081,104 bp from pter
- End:
- 33,178,892 bp from pter
- Size:
- 97,789 bases
- Orientation:
- Plus strand
Genomic View for AZIN2 Gene
Genes around AZIN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p35.1 by Ensembl
- 1p35.1 by Entrez Gene
- 1p35.1 by HGNC
AZIN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AZIN2 Gene
Proteins for AZIN2 Gene
-
Protein details for AZIN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96A70-AZIN2_HUMAN
- Recommended name:
- Antizyme inhibitor 2
- Protein Accession:
- Q96A70
- B2RDU5
- D3DPQ9
- Q5TIF4
- Q5TIF5
- Q5TIF6
- Q8TF56
- Q96L54
- Q96L55
- Q96L56
- Q96L57
- Q96MD9
Protein attributes for AZIN2 Gene
- Size:
- 460 amino acids
- Molecular mass:
- 49980 Da
- Quaternary structure:
-
- Monomer. Interacts with OAZ1, OAZ2 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1. Does not form a heterodimer with ODC1.
Protein Expression for AZIN2 Gene
Post-translational modifications for AZIN2 Gene
- Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AZIN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001280491.1
- NP_001288752.1
- NP_001288753.1
- NP_001288754.1
- NP_001288755.1
- NP_001337327.1
- NP_001337328.1
- NP_001337329.1
- NP_001337330.1
- NP_001337331.1
- NP_443724.1
- XP_005270461.1
- XP_005270463.1
- XP_005270464.1
- XP_006710375.1
- XP_011538859.1
- XP_011538865.1
- XP_011538868.1
- XP_016855656.1
- XP_016855657.1
- XP_016855658.1
- XP_016855659.1
- XP_016855660.1
- XP_016855661.1
- XP_016855662.1
- XP_016855663.1
- XP_016855664.1
- XP_016855665.1
- XP_016855666.1
- XP_016855667.1
Antibody Products
- Novus Biologicals Antibodies for AZIN2
- Invitrogen Antibodies for AZIN2
- antibodies-online Antibodies for AZIN2: See all 9
- GeneTex AZIN2 antibody for AZIN2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for AZIN2
- Origene Custom Protein Services for AZIN2
- antibodies-online Proteins for AZIN2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for AZIN2
Assay Products
- antibodies-online Kits for AZIN2: See all 3
No data available for DME Specific Peptides for AZIN2 Gene
Domains & Families for AZIN2 Gene
Protein Domains for AZIN2 Gene
Suggested Antigen Peptide Sequences for AZIN2 Gene
Graphical View of Domain Structure for InterPro Entry
Q96A70UniProtKB/Swiss-Prot:
AZIN2_HUMAN :- The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).
- Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
- Domain:
-
- The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).
- Family:
-
- Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
No data available for Gene Families for AZIN2 Gene
Function for AZIN2 Gene
Molecular function for AZIN2 Gene
- UniProtKB/Swiss-Prot Function:
- Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17900240 |
| GO:0008792 | arginine decarboxylase activity | TAS | -- |
| GO:0015489 | putrescine transmembrane transporter activity | IEA,ISS | -- |
| GO:0042978 | ornithine decarboxylase activator activity | ISS | -- |
Phenotypes for AZIN2 Gene
- MGI mutant phenotypes for AZIN2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AZIN2:
Animal Model Products
-
Taconic Biosciences Mouse Models for AZIN2
- Cyagen custom Knockout/knockin (KOKI) mouse models for AZIN2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AZIN2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AZIN2 gene
- Search ViGene Biosciences for AZIN2
CRISPR Products
-
OriGene CRISPR knockouts for AZIN2
-
Applied Biological Materials CRISPR for AZIN2
- GenScript: Design CRISPR guide RNA sequences for AZIN2
miRNA for AZIN2 Gene
- miRTarBase miRNAs that target AZIN2
-
- hsa-mir-375 (MIRT019757)
- hsa-mir-578 (MIRT498790)
- hsa-mir-1278 (MIRT526456)
- hsa-mir-28-3p (MIRT526457)
- hsa-mir-4446-5p (MIRT609522)
- hsa-mir-664b-3p (MIRT609523)
- hsa-mir-579-3p (MIRT609524)
- hsa-mir-5696 (MIRT609525)
- hsa-mir-153-5p (MIRT609526)
- hsa-mir-1250-3p (MIRT609527)
- hsa-mir-3117-3p (MIRT613506)
- hsa-mir-205-3p (MIRT615271)
- hsa-mir-8083 (MIRT617639)
- hsa-mir-3169 (MIRT617640)
- hsa-mir-4759 (MIRT617641)
- hsa-mir-138-2-3p (MIRT625245)
miRNA Products
- Search ViGene Biosciences for AZIN2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AZIN2
- Browse OriGene Inhibitory RNA Products For AZIN2
-
ViGene Biosciences ready-to-package AAV shRNAs for AZIN2 gene
Clone Products
- Sino Biological Human cDNA Clone for AZIN2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AZIN2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AZIN2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AZIN2
-
ViGene Biosciences adenoviral particle packaged cDNA for AZIN2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AZIN2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AZIN2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AZIN2 Gene
Localization for AZIN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AZIN2 Gene
- Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in an antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 19718454 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
Pathways & Interactions for AZIN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Arginine and proline metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Viral mRNA Translation | ||
| 4 | CDK-mediated phosphorylation and removal of Cdc6 | ||
Pathways by source for AZIN2 Gene
1 BioSystems pathway for AZIN2 Gene
4 Reactome pathways for AZIN2 Gene
2 KEGG pathways for AZIN2 Gene
Interacting Proteins for AZIN2 Gene
Selected Interacting proteins:
ENSP00000294517
Q96A70-AZIN2_HUMAN
for AZIN2 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006591 | ornithine metabolic process | IEA | -- |
| GO:0006596 | polyamine biosynthetic process | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0007283 | spermatogenesis | NAS | 11587527 |
| GO:0015847 | putrescine transport | IEA,ISS | -- |
No data available for SIGNOR curated interactions for AZIN2 Gene
Drugs & Compounds for AZIN2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| L-Arginine | Approved | Nutra | Full agonist, Agonist, Target | 0 | ||
| Carbon dioxide | Approved, Vet_approved | Pharma | 0 | |||
| Famotidine | Approved | Pharma | Histamine H2-receptor antagonist | 61 | ||
| Guanidine | Approved | Pharma | 0 | |||
| agmatine | Experimental, Investigational | Pharma | Activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for AZIN2 Gene
mRNA/cDNA for AZIN2 Gene
- (30) REFSEQ mRNAs :
- (84) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AZIN2
-
Applied Biological Materials CRISPR for AZIN2
- GenScript: Design CRISPR guide RNA sequences for AZIN2
miRNA Products
- Search ViGene Biosciences for AZIN2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AZIN2
- Browse OriGene Inhibitory RNA Products For AZIN2
-
ViGene Biosciences ready-to-package AAV shRNAs for AZIN2 gene
Clone Products
- Sino Biological Human cDNA Clone for AZIN2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AZIN2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AZIN2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - |
Expression for AZIN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Pancreatic juice (32.1) and Adipocyte (25.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AZIN2 Gene
NURSA nuclear receptor signaling pathways regulating expression of AZIN2 Gene:
AZIN2mRNA Expression by UniProt/SwissProt for AZIN2 Gene:
Q96A70-AZIN2_HUMAN
Tissue specificity:
Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.
Evidence on tissue expression from TISSUES for AZIN2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for AZIN2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AZIN2 Gene
Orthologs for AZIN2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADC 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADC 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ADC 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Adc 35 34 |
|
OneToOne | |
| Azin2 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Adc 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADC 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADC 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADC 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADC 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adc 34 |
|
||
| Str.8128 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Odc1 35 |
|
ManyToMany | |
| Odc2 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F53F10.2 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPE1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10349 35 |
|
OneToMany |
- Species where no ortholog for AZIN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for AZIN2 Gene
Variants for AZIN2 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016877 | -- | 33,092,249(+) | GGGAG(C/G)CTGGG | intron-variant | |
| rs1000048917 | -- | 33,148,566(+) | TTAGG(C/T)TTTCT | intron-variant | |
| rs1000050725 | -- | 33,119,619(+) | TATGA(C/T)GAATG | intron-variant | |
| rs1000077036 | -- | 33,098,806(+) | TCAAC(C/G)AGGCT | intron-variant | |
| rs1000082373 | -- | 33,162,597(+) | AGAGT(C/T)TTGTC | intron-variant, downstream-variant-500B |
Residual Variation Intolerance Score:
62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.73;
86.61% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AZIN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AZIN2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZIN2 Gene
Disorders for AZIN2 Gene
Relevant External Links for AZIN2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- AZIN2
No disorders were found for AZIN2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AZIN2 Gene
Publications for AZIN2 Gene
- Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K. … Andersson L.C. (Biochem. J. 2008) 2 3 4 22 64
- Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. (PMID: 14738999) Zhu M.-Y. … Regunathan S. (Biochim. Biophys. Acta 2004) 2 3 4 22 64
- Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes. (PMID: 11587527) Pitkaenen L.T. … Andersson L.C. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
- Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease. (PMID: 19832840) MAokitie L.T. … Andersson L.C. (Brain Pathol. 2010) 3 4 64
- Antizyme inhibitor 2: molecular, cellular and physiological aspects. (PMID: 19956990) LA^pez-Contreras A.J. … PeA+afiel R. (Amino Acids 2010) 3 4 64
Products for AZIN2 Gene
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- Browse R&D Systems for biochemical assays
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- OriGene qPCR primer pairs for AZIN2
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- GenScript: Next-day shipping of latest version cDNA ORF clones for AZIN2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AZIN2
- GenScript Custom Assay Services for AZIN2
- GenScript Custom overexpressing Cell Line Services for AZIN2
- GenScript: Design CRISPR guide RNA sequences for AZIN2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AZIN2
- Sino Biological Human cDNA Clone for AZIN2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for AZIN2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for AZIN2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for AZIN2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for AZIN2: See all 9
- antibodies-online Kits for AZIN2: See all 3
- antibodies-online Proteins for AZIN2: See all 3
- Search antibodies-online for peptides
- GeneTex AZIN2 antibody for AZIN2
- Search GeneTex for Proteins for AZIN2
- ViGene Biosciences adenoviral particle packaged cDNA for AZIN2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for AZIN2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for AZIN2 gene
- Search ViGene Biosciences for AZIN2
- Horizon Cell Lines for AZIN2
- Cyagen custom Knockout/knockin (KOKI) mouse models for AZIN2
- VectorBuilder custom plasmid, inducible vectors for AZIN2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AZIN2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AZIN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio