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AZIN1 Gene

protein-coding   GIFtS: 60
GCID: GC08M103838

Antizyme Inhibitor 1

(Previous name: ornithine decarboxylase antizyme inhibitor)
(Previous symbol: OAZIN)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Antizyme Inhibitor 11 2     OAZI2 3
OAZIN1 2 3 5     Ornithine Decarboxylase 1-Like1
Ornithine Decarboxylase Antizyme Inhibitor1 2 3     ODC1L2
AZI2 3     EC 4.1.1.178

External Ids:    HGNC: 164321   Entrez Gene: 515822   Ensembl: ENSG000001550967   OMIM: 6079095   UniProtKB: O149773   

Export aliases for AZIN1 gene to outside databases

Previous GC identifers: GC00U921561 GC08M103908 GC08M099039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AZIN1 Gene:
Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently
rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of
polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is
highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC
degradation. Two alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AZIN1 Gene:
AZIN1 (antizyme inhibitor 1) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase activator activity. An important paralog of this gene is ODC1.

UniProtKB/Swiss-Prot: AZIN1_HUMAN, O14977
Function: Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine
decarboxylase degradation by binding to antizyme

Gene Wiki entry for AZIN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AZIN1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AML1a   p300   E2F-2   MZF-1   E2F   E2F-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAZIN1 promoter sequence
   Search Chromatin IP Primers for AZIN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AZIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8p22-q21.3

AZIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZIN1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M103838:  view genomic region     (about GC identifiers)

Start:
103,838,536 bp from pter      End:
103,906,092 bp from pter
Size:
67,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AZIN1_HUMAN, O14977 (See protein sequence)
Recommended Name: Antizyme inhibitor 1  
Size: 448 amino acids; 49535 Da
Subunit: Monomer (By similarity)
Secondary accessions: A6NCD5 Q6IBQ7 Q96D20

Explore the universe of human proteins at neXtProt for AZIN1: NX_O14977

Explore proteomics data for AZIN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys125, Lys169, Lys175
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for AZIN1 (O14977)
     LDIGGGF  SQIKYAA  SDARCVFDM 


    See AZIN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056962.2  NP_680479.1  

    ENSEMBL proteins: 
     ENSP00000337180   ENSP00000321507   ENSP00000475919   ENSP00000429449   ENSP00000429215  
    Reactome Protein details: O14977

    AZIN1 Human Recombinant Protein Products:

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    Novus Biologicals AZIN1 Proteins
    Novus Biologicals AZIN1 Lysates
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    Cloud-Clone Corp. Proteins for AZIN1

     
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    antibodies-online proteins for AZIN1 (6 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR009006 Ala_racemase/Decarboxylase_C
     IPR000183 Orn/DAP/Arg_de-COase
     IPR022657 De-COase2_CS
     IPR002433 Orn_de-COase
     IPR022644 De-COase2_N

    Graphical View of Domain Structure for InterPro Entry O14977

    ProtoNet protein and cluster: O14977

    2 Blocks protein domains:
    IPB000183 Orn/DAP/Arg decarboxylase
    IPB002433 Ornithine decarboxylase signature


    UniProtKB/Swiss-Prot: AZIN1_HUMAN, O14977
    Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily


    Find genes that share domains with AZIN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AZIN1_HUMAN, O14977
    Function: Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine
    decarboxylase degradation by binding to antizyme

         Enzyme Number (IUBMB): EC 4.1.1.172

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0004857enzyme inhibitor activity TAS9349715
    GO:0042978ornithine decarboxylase activator activity IEA--
         
    Find genes that share ontologies with AZIN1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Azin1):
     growth/size/body  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with AZIN1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AZIN1

    miRNA
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    miRTarBase miRNAs that target AZIN1:
    hsa-mir-17-5p (MIRT050831), hsa-mir-30b-5p (MIRT023440)

    Block miRNA regulation of human, mouse, rat AZIN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AZIN1 (see all 65):
    hsa-miR-411* hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-138-2* hsa-miR-30a hsa-miR-4293 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidAZIN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AZIN1

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    GenScript: all cDNA clones in your preferred vector (see all 2): AZIN1 (NM_148174)
    Sino Biological Human cDNA Clone for AZIN1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZIN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with AZIN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AZIN1 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of ornithine decarboxylase (ODC)0.80
    2Metabolism
    Metabolism0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with AZIN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for AZIN1
        Diurnally regulated genes with circadian orthologs


    1 Reactome Pathway for AZIN1
        Regulation of ornithine decarboxylase (ODC)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AZIN1
    Interactions:

        Search GeneGlobe Interaction Network for AZIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for AZIN1 (O149771, 3 ENSP000003215074) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OAZ2O951901, 3EBI-1054824,EBI-1051861 I2D: score=2 
    FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
    FANCCQ005973, ENSP000002890814I2D: score=1 STRING: ENSP00000289081
    OAZ1ENSP000003148134STRING: ENSP00000314813
    OAZ3ENSP000003139224STRING: ENSP00000313922
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0006596polyamine biosynthetic process IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0043086negative regulation of catalytic activity TAS9349715
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with AZIN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AZIN1

    1 HMDB Compound for AZIN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AZIN1 gene (2 alternative transcripts): 
    NM_015878.4  NM_148174.2  

    Unigene Cluster for AZIN1:

    Antizyme inhibitor 1
    Hs.459106  [show with all ESTs]
    Unigene Representative Sequence: NM_015878
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337198(uc003ykx.3 uc003yky.3) ENST00000347770 ENST00000518697
    ENST00000523071 ENST00000521536 ENST00000522311 ENST00000520402 ENST00000518353
    ENST00000518940 ENST00000517581
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AZIN1 (see all 65):
    hsa-miR-411* hsa-miR-300 hsa-miR-485-3p hsa-miR-30d hsa-miR-138-2* hsa-miR-30a hsa-miR-4293 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidAZIN1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat AZIN1
      QuantiFast Probe-based Assays in human, mouse, rat AZIN1

    Additional mRNA sequence: 

    AF070634.1 AK095493.1 AK290516.1 BC013420.2 BC019279.1 BC042404.1 BT006858.1 CR456745.1 
    D88674.1 

    Selected DOTS entries (see all 36):

    DT.92463728  DT.100878296  DT.120631357  DT.95271065  DT.95271063  DT.120631377  DT.100762135  DT.92416836 
    DT.40117039  DT.100840249  DT.100774130  DT.120631284  DT.120631366  DT.120631517  DT.120631301  DT.95271068 
    DT.100743868  DT.120631306  DT.92463743  DT.95190460  DT.120631511  DT.120631551  DT.120631278  DT.120631344 

    Selected AceView cDNA sequences (see all 674):

    BC019279 AA825561 BM803229 CA440492 AI990871 BU521432 CF144031 CD643342 
    AI949432 AU280209 F06245 BX642799 NM_148174 AA232964 BU167808 AA233132 
    BQ924192 BQ431881 AA856694 BC013420 AI569112 BX956991 CD653615 BQ881213 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AZIN1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
    SP1:                    -                       -                                                     -                                   -                     
    SP2:                    -                       -     -                                               -                                   -                     
    SP3:                                                                                                  -                                   -                     
    SP4:                                                                                                                                      -                     
    SP5:                                            -     -                       -     -                 -                                                         

    ExUns: 15a · 15b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for AZIN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AZIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCACCC
    AZIN1 Expression
    About this image


    AZIN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Pancreas (Endocrine System)
     
     Esophagus (Gastrointestinal Tract)
    AZIN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AZIN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459106

    UniProtKB/Swiss-Prot: AZIN1_HUMAN, O14977
    Tissue specificity: Expressed in liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AZIN1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Azin11 , 5 antizyme inhibitor 11, 5 93.53(n)1
    95.76(a)1
      15 (15.17 cM)5
    543751  NM_001102458.11  NP_001095928.11 
     384874305 
    chicken
    (Gallus gallus)
    Aves AZIN11 antizyme inhibitor 1 81.77(n)
    77.68(a)
      420254  NM_001008729.1  NP_001008729.1 
    lizard
    (Anolis carolinensis)
    Reptilia AZIN16
    antizyme inhibitor 1
    76(a)
    1 ↔ 1
    4(13827205-13859491)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA790747.12   -- 81.4(n)    CA790747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC061960.12   -- 77.56(n)   317764  BC061960.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Odc16
    Odc26
    Ornithine decarboxylase 2
    36(a)
    35(a)
    many ↔ many
    many ↔ many
    2R(3892308-3894177)
    2R(3894769-3896567)
    worm
    (Caenorhabditis elegans)
    Secernentea F53F10.26
    Protein F53F10.2, isoform a
    19(a)
    1 → many
    I(3831117-3834124) WBGene00018764
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPE16
    Ornithine decarboxylase, catalyzes the first step ...
    31(a)
    1 → many
    XI(96757-98157) YKL184W


    ENSEMBL Gene Tree for AZIN1 (if available)
    TreeFam Gene Tree for AZIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AZIN1 gene
    ODC12  ADC2  
    2 SIMAP similar genes for AZIN1 using alignment to 4 protein entries:     AZIN1_HUMAN (see all proteins):
    ODC1    ADC

    Find genes that share paralogs with AZIN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AZIN1 (see all 756)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737015301,2
    C,F--103838055(+) TACTAG/ATGCAT 2 -- ds50012Minor allele frequency- A:0.10WA 120
    rs777153971,2
    F--103838130(+) TAACTA/GAAGTG 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1853945141,2
    --103838387(+) GAACTG/TAAGTG 2 -- ds50010--------
    rs1456880931,2
    --103838464(+) CTATAC/TATAAC 2 -- ds50010--------
    rs10623651,2
    C--103838674(-) AAATAC/TAAAAC 2 -- ut310--------
    rs1403341501,2
    C--103838677(+) TTATAA/TTTGCA 2 -- ut310--------
    rs1380471411,2
    C--103838848(+) TCACAC/TGTGAT 2 -- ut310--------
    rs32034441,2
    C,F--103838872(-) AAGAAA/GTAGCT 2 -- ut311Minor allele frequency- G:0.00MN 184
    rs69211,2
    C,F,A--103838876(+) ATTTCT/ATATAG 2 -- ut31 ese312Minor allele frequency- A:0.47MN NA WA CSA EA 557
    rs1906428691,2
    --103838884(+) TAGAAC/TAGCTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AZIN1 (103838536 - 103906092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AZIN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33118CNV Loss17666407
    nsv891245CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AZIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for AZIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607909    OMIM disorders: --


    Find genes that share disorders with AZIN1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: AZIN1 (1 document)

    Export disorders for AZIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AZIN1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with AZIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor. (PubMed id 9349715)1, 2, 3 Koguchi K....Hayashi S. (Biochim. Biophys. Acta 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    4. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. (PubMed id 23291631)1 Chen L....Guan X.Y. (Nat. Med. 2013)
    5. A candidate gene study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in chinese hepatitis B patients. (PubMed id 23844940)1 Peng L....Sninsky J.J. (Genet Test Mol Biomarkers 2013)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. [Polymorphism of ornithine decarboxylase antizyme inhibitor 1 gene is associated with liver cirrhosis in Chinese hepatitis B patients]. (PubMed id 21586232)1 Peng L.J....Wang J.Y. (Zhonghua Gan Zang Bing Za Zhi 2011)
    8. Minimal antizyme peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor. (PubMed id 21931692)1 Hsieh J.Y....Hung H.C. (PLoS ONE 2011)
    9. A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis. (PubMed id 21837750)1 Paris A.J....Friedman S.L. (Hepatology 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51582 HGNC: 16432 AceView: OAZIN Ensembl:ENSG00000155096 euGenes: HUgn51582
    ECgene: AZIN1 H-InvDB: AZIN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AZIN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AZIN1 gene:
    Search GeneIP for patents involving AZIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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