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Aliases for AZIN1 Gene

Aliases for AZIN1 Gene

  • Antizyme Inhibitor 1 2 3
  • Ornithine Decarboxylase Antizyme Inhibitor 2 3 4
  • OAZIN 3 4 6
  • OAZI 3 4
  • AZI 3 4
  • Ornithine Decarboxylase 1-Like 2
  • EC 4.1.1.17 64
  • ODC1L 3
  • AZIA1 3

External Ids for AZIN1 Gene

Previous Symbols for AZIN1 Gene

  • OAZIN

Summaries for AZIN1 Gene

Entrez Gene Summary for AZIN1 Gene

  • The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for AZIN1 Gene

AZIN1 (Antizyme Inhibitor 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase activator activity. An important paralog of this gene is AZIN2.

UniProtKB/Swiss-Prot for AZIN1 Gene

  • Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.

Gene Wiki entry for AZIN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZIN1 Gene

Genomics for AZIN1 Gene

Genomic Location for AZIN1 Gene

Start:
102,826,308 bp from pter
End:
102,893,864 bp from pter
Size:
67,557 bases
Orientation:
Minus strand

Genomic View for AZIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AZIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZIN1 Gene

Regulatory Elements for AZIN1 Gene

Proteins for AZIN1 Gene

  • Protein details for AZIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14977-AZIN1_HUMAN
    Recommended name:
    Antizyme inhibitor 1
    Protein Accession:
    O14977
    Secondary Accessions:
    • A6NCD5
    • Q6IBQ7
    • Q96D20

    Protein attributes for AZIN1 Gene

    Size:
    448 amino acids
    Molecular mass:
    49535 Da
    Quaternary structure:
    • Monomer. Interacts with OAZ1 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation

neXtProt entry for AZIN1 Gene

Proteomics data for AZIN1 Gene at MOPED

Selected DME Specific Peptides for AZIN1 Gene

Post-translational modifications for AZIN1 Gene

  • Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys47, Lys125, Lys169, and Lys175

Other Protein References for AZIN1 Gene

Domains for AZIN1 Gene

UniProtKB/Swiss-Prot:

AZIN1_HUMAN
Family:
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.:
    • O14977
genes like me logo Genes that share domains with AZIN1: view

No data available for Gene Families for AZIN1 Gene

Function for AZIN1 Gene

Molecular function for AZIN1 Gene

UniProtKB/Swiss-Prot Function: Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.

Enzyme Numbers (IUBMB) for AZIN1 Gene

Gene Ontology (GO) - Molecular Function for AZIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004586 NOT ornithine decarboxylase activity IBA --
GO:0004857 enzyme inhibitor activity --
GO:0005515 protein binding IPI 25416956
GO:0042978 ornithine decarboxylase activator activity IDA 17900240
genes like me logo Genes that share ontologies with AZIN1: view

Phenotypes for AZIN1 Gene

genes like me logo Genes that share phenotypes with AZIN1: view

miRNA for AZIN1 Gene

miRTarBase miRNAs that target AZIN1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AZIN1 Gene

Localization for AZIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZIN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AZIN1 Gene COMPARTMENTS Subcellular localization image for AZIN1 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AZIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AZIN1: view

Pathways for AZIN1 Gene

genes like me logo Genes that share pathways with AZIN1: view

Pathways by source for AZIN1 Gene

Gene Ontology (GO) - Biological Process for AZIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006596 polyamine biosynthetic process --
GO:0033387 putrescine biosynthetic process from ornithine IBA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0042177 negative regulation of protein catabolic process IDA 17900240
genes like me logo Genes that share ontologies with AZIN1: view

Compounds for AZIN1 Gene

(1) HMDB Compounds for AZIN1 Gene

Compound Synonyms Cas Number PubMed IDs
Ornithine
  • (+)-S-Ornithine
70-26-8
genes like me logo Genes that share compounds with AZIN1: view

Transcripts for AZIN1 Gene

Unigene Clusters for AZIN1 Gene

Antizyme inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AZIN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11: - - - - - -

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for AZIN1 Gene

GeneLoc Exon Structure for
AZIN1
ECgene alternative splicing isoforms for
AZIN1

Expression for AZIN1 Gene

mRNA expression in normal human tissues for AZIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AZIN1 Gene

SOURCE GeneReport for Unigene cluster for AZIN1 Gene Hs.459106

mRNA Expression by UniProt/SwissProt for AZIN1 Gene

O14977-AZIN1_HUMAN
Tissue specificity: Expressed in liver
genes like me logo Genes that share expressions with AZIN1: view

Orthologs for AZIN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AZIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZIN1 36
  • 99.93 (n)
  • 100 (a)
AZIN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AZIN1 36
  • 94.64 (n)
  • 94.2 (a)
AZIN1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AZIN1 36
  • 96.35 (n)
  • 95.97 (a)
AZIN1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Azin1 36
  • 93.53 (n)
  • 95.76 (a)
Azin1 16
Azin1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AZIN1 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Azin1 36
  • 91.44 (n)
  • 93.08 (a)
chicken
(Gallus gallus)
Aves AZIN1 36
  • 81.77 (n)
  • 77.68 (a)
AZIN1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AZIN1 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia azin1 36
  • 74.34 (n)
  • 68.34 (a)
Str.5995 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
azin1a 37
  • 52 (a)
OneToMany
azin1b 36
  • 61.4 (n)
  • 56.74 (a)
azin1b 37
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Odc1 37
  • 36 (a)
ManyToMany
Odc2 37
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.2 37
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE1 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10349 37
  • 34 (a)
OneToMany
Species with no ortholog for AZIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AZIN1 Gene

ENSEMBL:
Gene Tree for AZIN1 (if available)
TreeFam:
Gene Tree for AZIN1 (if available)

Paralogs for AZIN1 Gene

Paralogs for AZIN1 Gene

Selected SIMAP similar genes for AZIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AZIN1: view

Variants for AZIN1 Gene

Sequence variations from dbSNP and Humsavar for AZIN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1138 -- 102,856,258(+) TTACA(C/T)GTGAA intron-variant
rs2809 -- 102,827,135(-) TGGTG(C/T)CAATG utr-variant-3-prime
rs3836 -- 102,828,132(+) TAAAC(A/G)TTATC utr-variant-3-prime
rs6921 -- 102,826,648(+) ATTTC(A/T)TATAG utr-variant-3-prime
rs13123 -- 102,826,775(-) GTGCA(C/T)TGTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AZIN1 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV Loss 17666407
nsv891245 CNV Gain 21882294

Relevant External Links for AZIN1 Gene

HapMap Linkage Disequilibrium report
AZIN1
Human Gene Mutation Database (HGMD)
AZIN1

Disorders for AZIN1 Gene

Relevant External Links for AZIN1

Human Genome Epidemiology (HuGE) Navigator
AZIN1
genes like me logo Genes that share disorders with AZIN1: view

No data available for UniProtKB/Swiss-Prot for AZIN1 Gene

Publications for AZIN1 Gene

  1. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor. (PMID: 9349715) Koguchi K. … Hayashi S. (Biochim. Biophys. Acta 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K. … Andersson L.C. (Biochem. J. 2008) 3 4
  5. Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells. (PMID: 18508777) LA^pez-Contreras A.J. … PeA+afiel R. (J. Biol. Chem. 2008) 3

Products for AZIN1 Gene

Sources for AZIN1 Gene

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