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Aliases for AZIN1 Gene

Aliases for AZIN1 Gene

  • Antizyme Inhibitor 1 2 3 5
  • Ornithine Decarboxylase Antizyme Inhibitor 2 3 4
  • OAZIN 3 4
  • OAZI 3 4
  • AZI 3 4
  • Ornithine Decarboxylase 1-Like 2
  • EC 4.1.1.17 63
  • AZIA1 3
  • ODC1L 3

External Ids for AZIN1 Gene

Previous HGNC Symbols for AZIN1 Gene

  • OAZIN

Previous GeneCards Identifiers for AZIN1 Gene

  • GC00U921561
  • GC08M103908
  • GC08M099039
  • GC08M103838

Summaries for AZIN1 Gene

Entrez Gene Summary for AZIN1 Gene

  • The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for AZIN1 Gene

AZIN1 (Antizyme Inhibitor 1) is a Protein Coding gene. Diseases associated with AZIN1 include hepatocellular carcinoma. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase activator activity. An important paralog of this gene is AZIN2.

UniProtKB/Swiss-Prot for AZIN1 Gene

  • Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.

Gene Wiki entry for AZIN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZIN1 Gene

Genomics for AZIN1 Gene

Regulatory Elements for AZIN1 Gene

Genomic Location for AZIN1 Gene

Chromosome:
8
Start:
102,826,302 bp from pter
End:
102,893,864 bp from pter
Size:
67,563 bases
Orientation:
Minus strand

Genomic View for AZIN1 Gene

Genes around AZIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AZIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AZIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZIN1 Gene

Proteins for AZIN1 Gene

  • Protein details for AZIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14977-AZIN1_HUMAN
    Recommended name:
    Antizyme inhibitor 1
    Protein Accession:
    O14977
    Secondary Accessions:
    • A6NCD5
    • Q6IBQ7
    • Q96D20

    Protein attributes for AZIN1 Gene

    Size:
    448 amino acids
    Molecular mass:
    49535 Da
    Quaternary structure:
    • Monomer. Interacts with OAZ1 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation.

    Three dimensional structures from OCA and Proteopedia for AZIN1 Gene

neXtProt entry for AZIN1 Gene

Proteomics data for AZIN1 Gene at MOPED

Selected DME Specific Peptides for AZIN1 Gene

Post-translational modifications for AZIN1 Gene

  • Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.
  • Ubiquitination at Lys 47, Lys 125, Lys 169, and Lys 175
  • Modification sites at PhosphoSitePlus

Other Protein References for AZIN1 Gene

Domains & Families for AZIN1 Gene

Suggested Antigen Peptide Sequences for AZIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14977

UniProtKB/Swiss-Prot:

AZIN1_HUMAN :
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
Family:
  • Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
genes like me logo Genes that share domains with AZIN1: view

No data available for Gene Families for AZIN1 Gene

Function for AZIN1 Gene

Molecular function for AZIN1 Gene

UniProtKB/Swiss-Prot Function:
Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.

Enzyme Numbers (IUBMB) for AZIN1 Gene

genes like me logo Genes that share phenotypes with AZIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AZIN1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AZIN1 Gene

Localization for AZIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZIN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AZIN1 Gene COMPARTMENTS Subcellular localization image for AZIN1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for AZIN1 Gene

Pathways & Interactions for AZIN1 Gene

genes like me logo Genes that share pathways with AZIN1: view

Gene Ontology (GO) - Biological Process for AZIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0033387 putrescine biosynthetic process from ornithine IBA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AZIN1: view

No data available for SIGNOR curated interactions for AZIN1 Gene

Drugs & Compounds for AZIN1 Gene

(1) Drugs for AZIN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Full agonist, Agonist 63
genes like me logo Genes that share compounds with AZIN1: view

Transcripts for AZIN1 Gene

Unigene Clusters for AZIN1 Gene

Antizyme inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AZIN1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9:
SP10:
SP11: - - - - - -

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for AZIN1 Gene

GeneLoc Exon Structure for
AZIN1
ECgene alternative splicing isoforms for
AZIN1

Expression for AZIN1 Gene

mRNA expression in normal human tissues for AZIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AZIN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AZIN1 Gene



SOURCE GeneReport for Unigene cluster for AZIN1 Gene Hs.459106

mRNA Expression by UniProt/SwissProt for AZIN1 Gene

O14977-AZIN1_HUMAN
Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with AZIN1: view

Protein tissue co-expression partners for AZIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AZIN1 Gene

Orthologs for AZIN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AZIN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AZIN1 35
  • 94.64 (n)
  • 94.2 (a)
AZIN1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AZIN1 35
  • 96.35 (n)
  • 95.97 (a)
AZIN1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Azin1 35
  • 93.53 (n)
  • 95.76 (a)
Azin1 16
Azin1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AZIN1 35
  • 99.93 (n)
  • 100 (a)
AZIN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Azin1 35
  • 91.44 (n)
  • 93.08 (a)
oppossum
(Monodelphis domestica)
Mammalia AZIN1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves AZIN1 35
  • 81.77 (n)
  • 77.68 (a)
AZIN1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AZIN1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia azin1 35
  • 74.34 (n)
  • 68.34 (a)
Str.5995 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
azin1b 35
  • 61.4 (n)
  • 56.74 (a)
azin1a 36
  • 52 (a)
OneToMany
azin1b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Odc1 36
  • 36 (a)
ManyToMany
Odc2 36
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53F10.2 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10349 36
  • 34 (a)
OneToMany
Species with no ortholog for AZIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AZIN1 Gene

ENSEMBL:
Gene Tree for AZIN1 (if available)
TreeFam:
Gene Tree for AZIN1 (if available)

Paralogs for AZIN1 Gene

Paralogs for AZIN1 Gene

(2) SIMAP similar genes for AZIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AZIN1: view

Variants for AZIN1 Gene

Sequence variations from dbSNP and Humsavar for AZIN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs6921 -- 102,826,648(+) ATTTC(A/T)TATAG utr-variant-3-prime
rs13123 -- 102,826,775(-) GTGCA(C/T)TGTTG utr-variant-3-prime
rs1138 -- 102,856,258(+) TTACA(C/T)GTGAA intron-variant
rs2809 -- 102,827,135(-) TGGTG(C/T)CAATG utr-variant-3-prime
rs3836 -- 102,828,132(+) TAAAC(A/G)TTATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AZIN1 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV Loss 17666407
nsv891245 CNV Gain 21882294

Variation tolerance for AZIN1 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AZIN1 Gene

HapMap Linkage Disequilibrium report
AZIN1
Human Gene Mutation Database (HGMD)
AZIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZIN1 Gene

Disorders for AZIN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AZIN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search AZIN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AZIN1

Human Genome Epidemiology (HuGE) Navigator
AZIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AZIN1
genes like me logo Genes that share disorders with AZIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AZIN1 Gene

Publications for AZIN1 Gene

  1. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor. (PMID: 9349715) Koguchi K. … Hayashi S. (Biochim. Biophys. Acta 1997) 2 3 4 67
  2. ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. (PMID: 18062773) Snapir Z. … Kahana C. (Biochem. J. 2008) 3 23
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev D.E. … Baranov P.V. (Elife 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for AZIN1 Gene

Sources for AZIN1 Gene

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