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Aliases for AZI2 Gene

Aliases for AZI2 Gene

  • 5-Azacytidine Induced 2 2 3 5
  • NF-Kappa-B-Activating Kinase-Associated Protein 1 3 4
  • NAP1 3 4
  • TILP 3 4
  • 5-Azacytidine-Induced Protein 2 3
  • 5-Azacytidine Induced Gene 2 3
  • NAK-Associated Protein 1 3
  • Nak-Associated Protein 1 4
  • TBKBP2 4
  • AZ2 3

External Ids for AZI2 Gene

Summaries for AZI2 Gene

Entrez Gene Summary for AZI2 Gene

  • AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

GeneCards Summary for AZI2 Gene

AZI2 (5-Azacytidine Induced 2) is a Protein Coding gene. Diseases associated with AZI2 include Vaccinia. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.

UniProtKB/Swiss-Prot for AZI2 Gene

  • Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

Gene Wiki entry for AZI2 Gene

Additional gene information for AZI2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZI2 Gene

Genomics for AZI2 Gene

Regulatory Elements for AZI2 Gene

Enhancers for AZI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H027665 0.9 Ensembl ENCODE 10.4 +682.7 682694 1 PKNOX1 MXI1 RFX1 MAX BMI1 RAD21 ETS1 RFX3 POLR2A IKZF1 RNU1-96P ZCWPW2 AZI2 ENSG00000271943 ENSG00000232766
GH03H028326 0.8 ENCODE 11.5 +22.7 22679 1 PKNOX1 SIN3A BMI1 GATA3 GATA2 ATF7 NFE2 RUNX3 IKZF2 CHD2 ZCWPW2 AZI2 CMC1 GC03P028315
GH03H028292 0.7 Ensembl ENCODE 11.3 +54.7 54684 3 ZNF133 CEBPB CEBPG AZI2 ZCWPW2 CMC1 GC03P028315
GH03H028346 1.4 ENCODE dbSUPER 5.1 +1.2 1214 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 AZI2 ZCWPW2 GC03P028315
GH03H027927 0.5 FANTOM5 1.2 +421.3 421289 0 ZNF217 IKZF1 ELF1 IKZF2 AZI2 GC03P027916 LINC01967
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AZI2 on UCSC Golden Path with GeneCards custom track

Promoters for AZI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150063 724 2601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3

Genomic Location for AZI2 Gene

Chromosome:
3
Start:
28,315,003 bp from pter
End:
28,349,424 bp from pter
Size:
34,422 bases
Orientation:
Minus strand

Genomic View for AZI2 Gene

Genes around AZI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AZI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AZI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZI2 Gene

Proteins for AZI2 Gene

  • Protein details for AZI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6S1-AZI2_HUMAN
    Recommended name:
    5-azacytidine-induced protein 2
    Protein Accession:
    Q9H6S1
    Secondary Accessions:
    • A8K3M2
    • C9JB40
    • H7BXU6
    • Q86W99
    • Q9BQF1

    Protein attributes for AZI2 Gene

    Size:
    392 amino acids
    Molecular mass:
    44935 Da
    Quaternary structure:
    • Homodimer. Interacts with IKBKE, TBK1 and TICAM1.
    • (Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).

    Three dimensional structures from OCA and Proteopedia for AZI2 Gene

    Alternative splice isoforms for AZI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AZI2 Gene

Post-translational modifications for AZI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AZI2 Gene

Domains & Families for AZI2 Gene

Gene Families for AZI2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AZI2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AZI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AZI2: view

No data available for UniProtKB/Swiss-Prot for AZI2 Gene

Function for AZI2 Gene

Molecular function for AZI2 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

Gene Ontology (GO) - Molecular Function for AZI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with AZI2: view
genes like me logo Genes that share phenotypes with AZI2: view

Animal Models for AZI2 Gene

MGI Knock Outs for AZI2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AZI2 Gene

Localization for AZI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZI2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AZI2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for AZI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AZI2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AZI2 Gene

Pathways & Interactions for AZI2 Gene

genes like me logo Genes that share pathways with AZI2: view

Pathways by source for AZI2 Gene

1 BioSystems pathway for AZI2 Gene
1 KEGG pathway for AZI2 Gene

Gene Ontology (GO) - Biological Process for AZI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0001816 cytokine production IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0016032 viral process IEA --
GO:0032607 interferon-alpha production IEA --
genes like me logo Genes that share ontologies with AZI2: view

No data available for SIGNOR curated interactions for AZI2 Gene

Drugs & Compounds for AZI2 Gene

(1) Additional Compounds for AZI2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AZI2: view

Transcripts for AZI2 Gene

Unigene Clusters for AZI2 Gene

5-azacytidine induced 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AZI2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: -
SP6: - - - - - - -
SP7: -
SP8: - - - -
SP9:
SP10: - -

Relevant External Links for AZI2 Gene

GeneLoc Exon Structure for
AZI2
ECgene alternative splicing isoforms for
AZI2

Expression for AZI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AZI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AZI2 Gene

This gene is overexpressed in Lung (38.8) and NK cells (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AZI2 Gene



NURSA nuclear receptor signaling pathways regulating expression of AZI2 Gene:

AZI2

SOURCE GeneReport for Unigene cluster for AZI2 Gene:

Hs.706676

mRNA Expression by UniProt/SwissProt for AZI2 Gene:

Q9H6S1-AZI2_HUMAN
Tissue specificity: Widely expressed. Abundant expression seen in the pancreas and testis.

Evidence on tissue expression from TISSUES for AZI2 Gene

  • Liver(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with AZI2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AZI2 Gene

Orthologs for AZI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AZI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZI2 33 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia AZI2 33 34
  • 92.52 (n)
cow
(Bos Taurus)
Mammalia AZI2 33 34
  • 88.95 (n)
mouse
(Mus musculus)
Mammalia Azi2 33 16 34
  • 84.86 (n)
rat
(Rattus norvegicus)
Mammalia Azi2 33
  • 81.67 (n)
oppossum
(Monodelphis domestica)
Mammalia AZI2 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AZI2 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves AZI2 33 34
  • 69.04 (n)
lizard
(Anolis carolinensis)
Reptilia AZI2 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia azi2 33
  • 60.3 (n)
zebrafish
(Danio rerio)
Actinopterygii azi2 33 34
  • 52.33 (n)
Species where no ortholog for AZI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AZI2 Gene

ENSEMBL:
Gene Tree for AZI2 (if available)
TreeFam:
Gene Tree for AZI2 (if available)

Paralogs for AZI2 Gene

(1) SIMAP similar genes for AZI2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AZI2 Gene

genes like me logo Genes that share paralogs with AZI2: view

No data available for Paralogs for AZI2 Gene

Variants for AZI2 Gene

Sequence variations from dbSNP and Humsavar for AZI2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000248644 -- 28,331,787(+) CAGAA(C/T)TGAAG intron-variant, utr-variant-3-prime
rs1000423212 -- 28,325,062(+) TTGTG(-/AA)ATCTT intron-variant
rs1000563047 -- 28,323,105(+) CACTT(-/TCTC)AATAA downstream-variant-500B, utr-variant-3-prime
rs1000812479 -- 28,343,133(+) TTATT(A/G)TACCA intron-variant
rs1000968253 -- 28,335,727(+) AACAC(C/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AZI2 Gene

Variant ID Type Subtype PubMed ID
dgv1365e212 CNV loss 25503493
esv3568668 CNV loss 25503493
esv996568 OTHER inversion 20482838

Variation tolerance for AZI2 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AZI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AZI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZI2 Gene

Disorders for AZI2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AZI2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
vaccinia
- elite association - COSMIC cancer census association via MalaCards
Search AZI2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AZI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AZI2
genes like me logo Genes that share disorders with AZI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AZI2 Gene

Publications for AZI2 Gene

  1. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PMID: 15611223) Sasai M … Seya T (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 22 60
  2. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. (PMID: 14560022) Fujita F … Nakanishi M (Molecular and cellular biology 2003) 3 4 22 60
  3. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. (PMID: 21931555) Unterholzner L … Bowie AG (PLoS pathogens 2011) 3 4 60
  4. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. (PMID: 17568778) Ryzhakov G … Randow F (The EMBO journal 2007) 3 4 60
  5. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. (PMID: 17142768) Sasai M … Seya T (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 22 60

Products for AZI2 Gene

Sources for AZI2 Gene

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