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AZI2 Gene

protein-coding   GIFtS: 49
GCID: GC03M028340

5-Azacytidine Induced 2

  Search for AZI2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Azacytidine Induced 21 2     AZ22 5
NAP12 3 5     5-Azacytidine Induced Gene 22
TILP2 3 5     5-Azacytidine-Induced Protein 22
Nak-Associated Protein 12 3     TBKBP23
NF-Kappa-B-Activating Kinase-Associated Protein 12 3     

External Ids:    HGNC: 240021   Entrez Gene: 643432   Ensembl: ENSG000001635127   OMIM: 6099165   UniProtKB: Q9H6S13   

Export aliases for AZI2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AZI2 Gene:
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating
IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 (PubMed 14560022)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for AZI2 Gene:
AZI2 (5-azacytidine induced 2) is a protein-coding gene.

UniProtKB/Swiss-Prot: AZI2_HUMAN, Q9H6S1
Function: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates
serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of
NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of
NF-kappa-B. Participates in IFNB promoter activation via TICAM1

Gene Wiki entry for AZI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the AZI2 gene promoter:
         Pax-5   NCX/Ncx   IRF-1   STAT5A   AREB6   SRY   POU2F1   POU2F1a   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAZI2 promoter sequence
   Search Chromatin IP Primers for AZI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AZI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.1   Ensembl cytogenetic band:  3p24.1   HGNC cytogenetic band: 3p23

AZI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZI2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M028340:  view genomic region     (about GC identifiers)

Start:
28,356,494 bp from pter      End:
28,390,618 bp from pter
Size:
34,125 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AZI2_HUMAN, Q9H6S1 (See protein sequence)
Recommended Name: 5-azacytidine-induced protein 2  
Size: 392 amino acids; 44935 Da
Subunit: Homodimer. Interacts with IKBKE, TBK1 and TICAM1
Secondary accessions: A8K3M2 C9JB40 H7BXU6 Q86W99 Q9BQF1
Alternative splicing: 4 isoforms:  Q9H6S1-1   Q9H6S1-3   Q9H6S1-4   Q9H6S1-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for AZI2: NX_Q9H6S1

Explore proteomics data for AZI2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AZI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001127904.1  NP_001127905.1  NP_001258579.1  NP_071906.1  

    ENSEMBL proteins: 
     ENSP00000403133   ENSP00000419371   ENSP00000335609   ENSP00000391696   ENSP00000389577  
     ENSP00000412820   ENSP00000416380  

    AZI2 Human Recombinant Protein Products:

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    Novus Biologicals AZI2 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for AZI2

     
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    Cloud-Clone Corp. ELISAs for AZI2
    Cloud-Clone Corp. CLIAs for AZI2
    Search eBioscience for ELISAs for AZI2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024581 TBD

    Graphical View of Domain Structure for InterPro Entry Q9H6S1

    ProtoNet protein and cluster: Q9H6S1


    Find genes that share domains with AZI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AZI2_HUMAN, Q9H6S1
    Function: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates
    serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of
    NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of
    NF-kappa-B. Participates in IFNB promoter activation via TICAM1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14743216
         
    Find genes that share ontologies with AZI2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AZI2:
     Decreased viability with pacli 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Azi2):
     cellular  hematopoietic system  immune system  respiratory system 

    Find genes that share phenotypes with AZI2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Azi2tm1Aki for AZI2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AZI2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AZI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AZI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AZI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AZI2:
    hsa-mir-375 (MIRT019757)

    Block miRNA regulation of human, mouse, rat AZI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AZI2 (see all 29):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-607 hsa-miR-448 hsa-miR-520d-5p hsa-miR-539 hsa-miR-3660 hsa-miR-885-5p
    SwitchGear 3'UTR luciferase reporter plasmidAZI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AZI2
    Predesigned siRNA for gene silencing in human, mouse, rat AZI2

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AZI2 (NM_001134433)
    Sino Biological Human cDNA Clone for AZI2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZI2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AZI2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for AZI2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AZI2_HUMAN, Q9H6S1: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    plasma membrane4
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----
    GO:0005886plasma membrane ----

    Find genes that share ontologies with AZI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AZI2 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.47
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with AZI2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for AZI2
        TNF-alpha/NF-kB Signaling Pathway



    1 Kegg Pathway  (Kegg details for AZI2):
        RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including AZI2: 
              Antiviral Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AZI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for AZI2 (Q9H6S11, 2, 3 ENSP000004193714) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-359973,EBI-356402 MINT-48042 MINT-49256 I2D: score=6 STRING: ENSP00000329967
    TICAM1Q8IUC63, ENSP000002482444I2D: score=2 STRING: ENSP00000248244
    N4BP1O751133, ENSP000002623844I2D: score=1 STRING: ENSP00000262384
    RNF31Q96EP03, ENSP000003151124I2D: score=1 STRING: ENSP00000315112
    TBKBP1A7MCY63, ENSP000003547774STRING: ENSP00000354777 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--

    Find genes that share ontologies with AZI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AZI2

    1 Novoseek inferred chemical compound relationship for AZI2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 81.7 1 17142768 (1)



    Find genes that share compounds with AZI2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AZI2 gene (4 alternative transcripts): 
    NM_001134432.1  NM_001134433.1  NM_001271650.1  NM_022461.4  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429369 ENST00000479665(uc003ceb.3 uc003cec.3) ENST00000295748
    ENST00000476174 ENST00000492044 ENST00000463512(uc003cee.4) ENST00000334100
    ENST00000488978 ENST00000470234 ENST00000420543(uc011axd.1 uc003ceg.2)
    ENST00000457172 ENST00000414162 ENST00000462936 ENST00000415852
    miRNA
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    Block miRNA regulation of human, mouse, rat AZI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AZI2 (see all 29):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-607 hsa-miR-448 hsa-miR-520d-5p hsa-miR-539 hsa-miR-3660 hsa-miR-885-5p
    SwitchGear 3'UTR luciferase reporter plasmidAZI2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AZI2
    Clone
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    OriGene ORF clones in mouse, rat for AZI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): AZI2 (NM_001134433)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZI2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AZI2
    Primer
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    OriGene qPCR primer pairs and template standards for AZI2
    OriGene qSTAR qPCR primer pairs in human, mouse for AZI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AZI2
      QuantiTect SYBR Green Assays in human, mouse, rat AZI2
      QuantiFast Probe-based Assays in human, mouse, rat AZI2

    Selected AceView cDNA sequences (see all 304):

    NM_022461 C02531 CF528511 BU782741 NM_203326 BX399142 AI336192 AA491507 
    AA857575 BU620765 BM981726 CN478710 BM763923 BU078920 AI753698 BU621093 
    CA448951 AV651892 AW594201 BC001853 BM982133 BF000175 AV651297 CA429488 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AZI2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
    SP1:                                -     -     -                                               -                       -     -     -                     
    SP2:                                -     -                                                     -                                                         
    SP3:                                                                                            -                                                         
    SP4:                                -     -     -                                   -     -     -                                                         
    SP5:                                -                                                                                                                     


    ECgene alternative splicing isoforms for AZI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AZI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGCATA
    AZI2 Expression
    About this image


    AZI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Adipose (Muscoskeletal System)
    AZI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AZI2 Protein Expression

    UniProtKB/Swiss-Prot: AZI2_HUMAN, Q9H6S1
    Tissue specificity: Widely expressed. Abundant expression seen in the pancreas and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including AZI2: 
              Antiviral Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AZI2
    OriGene qSTAR qPCR primer pairs in human, mouse for AZI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AZI2
    QuantiTect SYBR Green Assays in human, mouse, rat AZI2
    QuantiFast Probe-based Assays in human, mouse, rat AZI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AZI2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Azi21 , 5 5-azacytidine induced gene 21, 5 84.86(n)1
    84.44(a)1
      9 (69.86 cM)5
    272151  NM_001286508.11  NP_001273437.11 
     1180404995 
    chicken
    (Gallus gallus)
    Aves AZI21 5-azacytidine induced 2 69.04(n)
    67.28(a)
      420660  XM_418759.4  XP_418759.4 
    lizard
    (Anolis carolinensis)
    Reptilia AZI26
    5-azacytidine induced 2
    57(a)
    1 ↔ 1
    1(195977012-196000518)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia azi21 5-azacytidine induced 2 60.3(n)
    51.04(a)
      100487986  XM_004915383.1  XP_004915440.1 
    zebrafish
    (Danio rerio)
    Actinopterygii azi21 5-azacytidine induced 2 52.33(n)
    43(a)
      406377  NM_214733.1  NP_999898.1 


    ENSEMBL Gene Tree for AZI2 (if available)
    TreeFam Gene Tree for AZI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AZI2 gene
    1 SIMAP similar gene for AZI2 using alignment to 4 protein entries:     AZI2_HUMAN (see all proteins):
    TBKBP1

    Find genes that share paralogs with AZI2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for AZI2
    PGOHUM00000246775 PGOHUM00000247104 PGOHUM00000232587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AZI2 (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883541491,2
    --28363426(+) GATTCC/TAAAGG 2 -- int10--------
    rs1916590981,2
    --28363546(+) TTTTAC/TCTAGA 2 -- int10--------
    rs173572061,2
    C,F,H--28363559(+) AGAGAT/GATCAA 2 -- int126Minor allele frequency- G:0.17NA NS EA WA 2728
    rs1427025891,2
    --28363948(+) CAAAGA/GAAAAT 2 -- ut310--------
    rs1510087781,2
    --28364010(+) GATATA/GATATA 2 -- ut310--------
    rs1408505731,2
    --28364033(+) CCACAC/TGAGAA 2 -- ut310--------
    rs1850273081,2
    --28364207(+) TGACAC/GCAATT 2 -- ut310--------
    rs1459244321,2
    C--28364312(+) AATACA/CGTAGA 2 -- ut310--------
    rs1479100731,2
    --28364332(+) AGATAC/TTGAGT 2 -- ut310--------
    rs1416689721,2
    C--28364346(+) AGATAC/TATGAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AZI2 (28356494 - 28390618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AZI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876649CNV Gain21882294
    esv996568OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609916    OMIM disorders: --


    Find genes that share disorders with AZI2           About GenesLikeMe


    Export disorders for AZI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AZI2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with AZI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of NAP1, a regulatory subunit of IkappaB kinase- related kinases that potentiates NF-kappaB signaling. (PubMed id 14560022)1, 2, 9 Fujita F.... Nakanishi M. (Mol. Cell. Biol. 2003)
    2. NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PubMed id 15611223)1, 2, 9 Sasai M....Seya T. (J. Immunol. 2005)
    3. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. (PubMed id 17568778)1, 2 Ryzhakov G. and Randow F. (EMBO J. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus. (PubMed id 10580148)1, 3 Miyagawa J....Tajima S. (Gene 1999)
    6. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. (PubMed id 17142768)1, 9 Sasai M....Seya T. (J. Immunol. 2006)
    7. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-I^ production and antiviral response by targeting NAP1. (PubMed id 22539786)1 Zhao W....Gao C. (J. Immunol. 2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    9. Functional dissection of the TBK1 molecular network. (PubMed id 21931631)2 Goncalves A....Superti-Furga G. (PLoS ONE 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64343 HGNC: 24002 AceView: AZI2 Ensembl:ENSG00000163512 euGenes: HUgn64343
    ECgene: AZI2 Kegg: 64343 H-InvDB: AZI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AZI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AZI2 gene:
    Search GeneIP for patents involving AZI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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