Aliases for AZI2 Gene
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
GeneCards Summary for AZI2 Gene
AZI2 (5-Azacytidine Induced 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
UniProtKB/Swiss-Prot for AZI2 Gene
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.