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Aliases for AZI2 Gene

Aliases for AZI2 Gene

  • 5-Azacytidine Induced 2 2 3
  • NAP1 3 4 6
  • TILP 3 4 6
  • NF-Kappa-B-Activating Kinase-Associated Protein 1 3 4
  • AZ2 3 6
  • 5-Azacytidine-Induced Protein 2 3
  • 5-Azacytidine Induced Gene 2 3
  • NAK-Associated Protein 1 3
  • Nak-Associated Protein 1 4
  • TBKBP2 4

External Ids for AZI2 Gene

Summaries for AZI2 Gene

Entrez Gene Summary for AZI2 Gene

  • AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

GeneCards Summary for AZI2 Gene

AZI2 (5-Azacytidine Induced 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.

UniProtKB/Swiss-Prot for AZI2 Gene

  • Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

Gene Wiki entry for AZI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZI2 Gene

Genomics for AZI2 Gene

Regulatory Elements for AZI2 Gene

Genomic Location for AZI2 Gene

Start:
28,315,003 bp from pter
End:
28,349,424 bp from pter
Size:
34,422 bases
Orientation:
Minus strand

Genomic View for AZI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AZI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZI2 Gene

Proteins for AZI2 Gene

  • Protein details for AZI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6S1-AZI2_HUMAN
    Recommended name:
    5-azacytidine-induced protein 2
    Protein Accession:
    Q9H6S1
    Secondary Accessions:
    • A8K3M2
    • C9JB40
    • H7BXU6
    • Q86W99
    • Q9BQF1

    Protein attributes for AZI2 Gene

    Size:
    392 amino acids
    Molecular mass:
    44935 Da
    Quaternary structure:
    • Homodimer. Interacts with IKBKE, TBK1 and TICAM1.

    Alternative splice isoforms for AZI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AZI2 Gene

Proteomics data for AZI2 Gene at MOPED

Post-translational modifications for AZI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AZI2 Gene

Domains for AZI2 Gene

Protein Domains for AZI2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AZI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AZI2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AZI2 Gene

Function for AZI2 Gene

Molecular function for AZI2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

Gene Ontology (GO) - Molecular Function for AZI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with AZI2: view
genes like me logo Genes that share phenotypes with AZI2: view

Animal Models for AZI2 Gene

MGI Knock Outs for AZI2:

miRNA for AZI2 Gene

miRTarBase miRNAs that target AZI2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AZI2 Gene

Localization for AZI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZI2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AZI2 Gene COMPARTMENTS Subcellular localization image for AZI2 gene
Compartment Confidence
mitochondrion 4
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for AZI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AZI2: view

Pathways for AZI2 Gene

genes like me logo Genes that share pathways with AZI2: view

Pathways by source for AZI2 Gene

1 BioSystems pathway for AZI2 Gene
1 KEGG pathway for AZI2 Gene

Gene Ontology (GO) - Biological Process for AZI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0001816 cytokine production --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0032607 interferon-alpha production IEA --
GO:0032609 interferon-gamma production IEA --
genes like me logo Genes that share ontologies with AZI2: view

Compounds for AZI2 Gene

(1) Novoseek inferred chemical compound relationships for AZI2 Gene

Compound -log(P) Hits PubMed IDs
poly(i-c) 81.7 1
genes like me logo Genes that share compounds with AZI2: view

Transcripts for AZI2 Gene

Unigene Clusters for AZI2 Gene

5-azacytidine induced 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AZI2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - - - - - -
SP5: -
SP6: - - - - - - -
SP7: -
SP8: - - - -
SP9:
SP10: - -

Relevant External Links for AZI2 Gene

GeneLoc Exon Structure for
AZI2
ECgene alternative splicing isoforms for
AZI2

Expression for AZI2 Gene

mRNA expression in normal human tissues for AZI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AZI2 Gene

SOURCE GeneReport for Unigene cluster for AZI2 Gene Hs.706676

mRNA Expression by UniProt/SwissProt for AZI2 Gene

Q9H6S1-AZI2_HUMAN
Tissue specificity: Widely expressed. Abundant expression seen in the pancreas and testis.
genes like me logo Genes that share expressions with AZI2: view

No data available for mRNA differential expression in normal tissues for AZI2 Gene

Orthologs for AZI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AZI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZI2 35
  • 99.83 (n)
  • 100 (a)
AZI2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AZI2 35
  • 88.95 (n)
  • 88.78 (a)
AZI2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AZI2 35
  • 92.52 (n)
  • 91.07 (a)
AZI2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Azi2 35
  • 84.86 (n)
  • 84.44 (a)
Azi2 16
Azi2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AZI2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AZI2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Azi2 35
  • 81.67 (n)
  • 81.59 (a)
chicken
(Gallus gallus)
Aves AZI2 35
  • 69.04 (n)
  • 67.28 (a)
AZI2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AZI2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia azi2 35
  • 60.3 (n)
  • 51.04 (a)
zebrafish
(Danio rerio)
Actinopterygii azi2 35
  • 52.33 (n)
  • 43 (a)
azi2 36
  • 38 (a)
OneToOne
Species with no ortholog for AZI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AZI2 Gene

ENSEMBL:
Gene Tree for AZI2 (if available)
TreeFam:
Gene Tree for AZI2 (if available)

Paralogs for AZI2 Gene

Selected SIMAP similar genes for AZI2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AZI2 Gene

genes like me logo Genes that share paralogs with AZI2: view

No data available for Paralogs for AZI2 Gene

Variants for AZI2 Gene

Sequence variations from dbSNP and Humsavar for AZI2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1975829 -- 28,339,124(-) ggtgc(A/G)cctat intron-variant, upstream-variant-2KB
rs3068913 -- 28,331,015(+) ACAGA(-/AA)GATTT intron-variant
rs3068916 -- 28,339,482(+) GCCAA(-/TA)TGTTA intron-variant, upstream-variant-2KB
rs3214861 -- 28,323,021(-) CACAC(-/TT)ATTCT utr-variant-3-prime
rs3217694 -- 28,331,980(-) ATTTA(-/A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AZI2 Gene

Variant ID Type Subtype PubMed ID
nsv876649 CNV Gain 21882294
esv996568 OTHER Inversion 20482838

Relevant External Links for AZI2 Gene

HapMap Linkage Disequilibrium report
AZI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZI2 Gene

Disorders for AZI2 Gene

No disorders were found for AZI2 Gene.

No data available for UniProtKB/Swiss-Prot for AZI2 Gene

Publications for AZI2 Gene

  1. Identification of NAP1, a regulatory subunit of IkappaB kinase- related kinases that potentiates NF-kappaB signaling. (PMID: 14560022) Fujita F. … Nakanishi M. (Mol. Cell. Biol. 2003) 3 4 23
  2. NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PMID: 15611223) Sasai M. … Seya T. (J. Immunol. 2005) 3 4 23
  3. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. (PMID: 17142768) Sasai M. … Seya T. (J. Immunol. 2006) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. (PMID: 17568778) Ryzhakov G. … Randow F. (EMBO J. 2007) 3 4

Products for AZI2 Gene

Sources for AZI2 Gene

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