AZI1 Gene
protein-coding GIFtS : 52
GCID: GC17 M079163
5-azacytidine induced 1
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Aliasesfor AZI1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases 5-Azacytidine Induced 1 1 2 Pre-Acrosome Localization Protein 12 3 KIAA11181 3 5 Cep1312 3 AZ11 2 ZA12 5 CEP1311 3 5-Azacytidine-Induced Protein 12 Centrosomal Protein Of 131 KDa2 3 Centrosomal Protein 131 KDa2
Export aliases for AZI1 gene to outside databases Previous GC identifers: GC17M079725 GC17M079863 GC17M076777 GC17M074602
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Summariesfor AZI1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: AZI1_HUMAN, Q9UPN4 Function : May play a role in spermatogenesis (By similarity)Gene Wiki entry for AZI1
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Genomic Viewsfor AZI1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the AZI1 gene promoter: ISGF-3 C/EBPbeta Sp1 p53 LCR-F1 HEN1 Pax-3 ARP-1 Pax-4a ATF Other transcription factors Search SABiosciences Chromatin IP Primers for AZI1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AZI1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3 AZI1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M079163: view genomic region
(about GC identifiers )
Start:
79,163,393 bp from pter
End:
79,196,799 bp from pter
Size:
33,407 bases
Orientation:
minus strand
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Proteinsfor AZI1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AZI1_HUMAN, Q9UPN4 (See
protein sequence )Recommended Name: 5-azacytidine-induced protein 1 Size : 1083 amino acids; 122149 Da
Subcellular location : Cytoplasm, cytoskeleton, centrosome
Sequence caution : Sequence=BAA83070.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions : A6NHI8 B2RN11 Q96F50Alternative splicing : 3 isoforms : Q9UPN4-1 Q9UPN4-2 Q9UPN4-3 (Contains a phosphoserine at position 489. Contains a phosphoserine at position 496)Explore the universe of human proteins at neXtProt for AZI1: NX_Q9UPN4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UPN4 AZI1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001009811.2 NP_055799.2 ENSEMBL proteins: ENSP00000363914 ENSP00000269392 ENSP00000461374 ENSP00000460006 ENSP00000393583 ENSP00000459733 ENSP00000460098 Reactome Protein details: Q9UPN4 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
AZI1 for ontologies About GeneDecksing AZI1 Antibody Products: Assay Products for AZI1:
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Protein
Domains / Familiesfor AZI1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9UPN4
UniProtKB/Swiss-Prot: AZI1_HUMAN, Q9UPN4 Similarity : Contains 1 IQ domain
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Functionfor AZI1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AZI1_HUMAN, Q9UPN4 Function : May play a role in spermatogenesis (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AZI1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AZI1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AZI1 (NM_014984 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AZI1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AZI1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZI1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
AZI1 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for AZI1 :
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Pathways & Interactionsfor AZI1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Recruitment of mitotic centrosome proteins and complexes 2 Cell Cycle
Pathway sources See GeneCards unified pathways Show all pathways 5/8
Reactome Pathways for AZI1 (see all 8 )
AZI1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AZI1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/61 Interacting proteins for AZI1 (Q9UPN4 3 ENSP00000393583 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 61 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
AZI1 for ontologies About GeneDecksing
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Drugs & Compoundsfor AZI1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for AZI1 Search CenterWatch for drugs/clinical trials and news about AZI1
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Transcriptsfor AZI1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for AZI1 gene (2 alternative transcripts): NM_001009811.2 NM_014984.2 Unigene Cluster for AZI1:
5-azacytidine induced 1 Hs.514578 [show with all ESTs ] Unigene Representative Sequence: BC012130 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000374782 ENST00000269392 (uc002jzm.1 uc002jzn.1 uc002jzo.1 uc002jzp.1 uc010wum.1 )ENST00000570817 ENST00000573053 (uc002jzq.3 ) ENST00000450824 ENST00000575907 ENST00000571292 ENST00000570482 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AZI1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AZI1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): AZI1 (NM_014984 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AZI1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AZI1
Additional cDNA sequence: AB029041.1 BC010413.2 BC011615.2 BC012130.1 BC040023.1 BC136578.1 BC136580.1 BC144263.1
6 DOTS entries : DT.70104946 DT.92424048
DT.100697986 DT.435887 DT.100802481 DT.92049878 24/65 AceView cDNA sequences (see all 65 ):
BE384437 BQ637523 BE734213 BU165495 BC010413 BQ069739 BE902597 BM911459 BC040023 BG031900 BF591342 BC011615 AL135248 CO250199 BM927610 BQ643385 AB029041 BM009715 BF343215 BF974651 BX391524 BG109696 CF125276 AI817702 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AZI1 (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ SP1 :           -                                           SP2 :                           -                           SP3 :                                             -         SP4 :                                                     SP5 :                                             -        
ExUns: 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27 SP1 : -                 SP2 : -                 SP3 : -                 SP4 :                 SP5 :                
ECgene alternative splicing isoforms for AZI1
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Expression for AZI1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section AZI1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGGCTGCGGT
About this image AZI1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See AZI1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for AZI1 SOURCE GeneReport for Unigene cluster: Hs.514578 SABiosciences Custom PCR Arrays for AZI1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AZI1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat AZI1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AZI1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AZI1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZI1
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Orthologsfor AZI1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for AZI1 gene from 6/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for AZI1 (if available)TreeFam Gene Tree for AZI1 (if available)
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Paralogsfor AZI1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor AZI1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for AZI1 (79163393 - 79196799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for AZI1 4 CNVs : 73071 30032 4048 30855 1 Indel : 25954
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AZI1
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Disorders
/ Diseasesfor AZI1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
AZI1 for disorders About MalaCards
AZI1 for disorders About GeneDecksing
OMIM gene information: 613479
OMIM disorders : --Export disorders for AZI1 gene to outside databases
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Publicationsfor AZI1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for AZI1 gene, integrated from 9 sources (see all 34 ): (articles sorted by number of sources associating them with AZI1) Utopia : connect your pdf to the dynamic world of online information
Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843) 1 , 2 , 3 Andersen J.S....Mann M. (2003) Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851) 1 , 2 , 3 Kikuno R....Ohara O. (1999) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids. (PubMed id 9070930) 1 , 3 Aoto H....Tajima S. (1997) ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1. (PubMed id 18062773) 1 , 9 Snapir Z....Kahana C. (2008) Regulation of CEP131 gene expression by SP1. (PubMed id 23137637) 1 Huong P.T....Kim B.Y. (2013) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011)
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External Searches for AZI1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing AZI1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing AZI1 gene
(According to HUGE )
About This Section
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Specialized Databases showing AZI1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for AZI1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for AZI1 gene: Search GeneIP for patents involving AZI1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor AZI1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for AZI1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for AZI1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for AZI1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for AZI1 OriGene 3'-UTR Clone for AZI1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for AZI1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for AZI1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for AZI1 OriGene Custom Protein Services for AZI1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AZI1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing AZI1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat AZI1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat AZI1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat AZI1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat AZI1
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AZI1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZI1
ThermoFisher Antibodies for AZI1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat AZI1
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Aliases for AZI1
Databases for AZI1
Disorders / Diseases for AZI1
Domains / Families for AZI1
Drugs / Compounds for AZI1
Expression for AZI1
Function for AZI1
Genomic Views for AZI1
Intellectual Property for AZI1
Orthologs for AZI1
Paralogs for AZI1
Pathways / Interactions for AZI1
Products for AZI1
Proteins for AZI1
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Search Box for AZI1
Summaries for AZI1
Transcripts for AZI1
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