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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AZGP1 Gene

protein-coding   GIFtS: 58
GCID: GC07M099564

Alpha-2-Glycoprotein 1, Zinc-Binding

(Previous names: alpha-2-glycoprotein 1, zinc)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alpha-2-Glycoprotein 1, Zinc-Binding1 2     zinc-alpha-2-glycoprotein2
ZAG2 3 5     zn-alpha-2-GP2
Alpha-2-Glycoprotein 1, Zinc1     zn-alpha-2-glycoprotein2
ZA2G2     ZNGP13
Zn-alpha2-glycoprotein2     Zn-alpha-2-GP3
Alpha-2-Glycoprotein, Zinc2     Zn-alpha-2-glycoprotein3

External Ids:    HGNC: 9101   Entrez Gene: 5632   Ensembl: ENSG000001608627   OMIM: 1944605   UniProtKB: P253113   

Export aliases for AZGP1 gene to outside databases

Previous GC identifers: GC07M098099 GC07M099161 GC07M099175 GC07M099209 GC07M099402 GC07M094200


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AZGP1 Gene: 
AZGP1 (alpha-2-glycoprotein 1, zinc-binding) is a protein-coding gene. Diseases associated with AZGP1 include clear cell hidradenoma, and hidrocystoma. GO annotations related to this gene include protein transmembrane transporter activity and fatty acid binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some
advanced cancers. May bind polyunsaturated fatty acids

Gene Wiki entry for AZGP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AZGP1 gene promoter:
         Max1   NF-1   Elk-1   NCX/Ncx   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAZGP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AZGP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZGP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

AZGP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZGP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099564:  view genomic region     (about GC identifiers)

Start:
99,564,343 bp from pter      End:
99,573,780 bp from pter
Size:
9,438 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,924,486-98,933,868     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311 (See protein sequence)
Recommended Name: Zinc-alpha-2-glycoprotein precursor  
Size: 298 amino acids; 34259 Da
Subunit: Interacts with PIP
Subcellular location: Secreted
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA14417.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA42438.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
6/8 PDB 3D structures from and Proteopedia for AZGP1 (see all 8):
1T7V (3D)        1T7W (3D)        1T7X (3D)        1T7Y (3D)        1T7Z (3D)        1T80 (3D)    
Secondary accessions: D6W5T8 O60386 Q5XKQ4 Q8N4N0

Explore the universe of human proteins at neXtProt for AZGP1: NX_P25311

Explore proteomics data for AZGP1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25311

  • AZGP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AZGP1 Protein Expression
    REFSEQ proteins: NP_001176.1  
    ENSEMBL proteins: 
     ENSP00000292401   ENSP00000389942   ENSP00000396093  

    Human Recombinant Protein Products for AZGP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AZGP1 (ZAG)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for AZGP1
    OriGene Custom MassSpec 
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    Novus Biologicals AZGP1 Proteins
    Novus Biologicals AZGP1 Lysates
    Sino Biological Recombinant Protein for AZGP1
    Sino Biological Cell Lysate for AZGP1 
    ProSpec Recombinant Protein for AZGP1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IBA--
    GO:0005886plasma membrane IBA--
    GO:0042612MHC class I protein complex IEA--

    AZGP1 for ontologies           About GeneDecksing



    AZGP1 Antibody Products: 
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    Novus Biologicals AZGP1 Antibodies
    Abcam antibodies for AZGP1
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    ThermoFisher Antibodies for AZGP1
    LSBio Antibodies in human, mouse, rat for AZGP1 

    Assay Products for AZGP1: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR011161 MHC_I-like_Ag-recog
     IPR001039 MHC_I_a_a1/a2
     IPR011162 MHC_I/II-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry P25311

    ProtoNet protein and cluster: P25311

    2 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    AZGP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZA2G_HUMAN, P25311
    Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some
    advanced cancers. May bind polyunsaturated fatty acids

         Genatlas biochemistry entry for AZGP1:
    zinc alpha-2-glycoprotein 1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IBA--
    GO:0004540ribonuclease activity NAS10462714
    GO:0005515protein binding ----
    GO:0008320protein transmembrane transporter activity NAS6896906
    GO:0042605peptide antigen binding IEA--
         
    AZGP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AZGP1:
     Synthetic lethal with imatinib 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Azgp1):
     adipose tissue  growth/size  hematopoietic system  homeostasis/metabolism  immune system 

    AZGP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AZGP1: Azgp1tm1Lex Azgp1tm1.1Sbah

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AZGP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AZGP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AZGP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AZGP1 

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Sino Biological Human cDNA Clone for AZGP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AZGP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AZGP1
    Sirion Biotech Customized lentivirus for stable overexpression of AZGP1 
                         Customized lentivirus expression plasmids for stable overexpression of AZGP1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZGP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AZGP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for AZGP1 (P253113 ENSP000002924014) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP53Q70EK83, ENSP000002740304I2D: score=2 STRING: ENSP00000274030
    ITGAVP067563, ENSP000002610234I2D: score=1 STRING: ENSP00000261023
    APCP250543I2D: score=2 
    C12orf44Q9BSB43I2D: score=1 
    GOSR1O952493I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I IEA--
    GO:0006955immune response IEA--
    GO:0007155cell adhesion ISS--
    GO:0008285negative regulation of cell proliferation NAS10462714

    AZGP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AZGP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AZGP1 (ZA2G)

    2 DrugBank Compounds for AZGP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----
    O-Sialic Acid-- --target----

    7 Novoseek inferred chemical compound relationships for AZGP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyacrylamide 44.7 3 1592045 (1), 2265857 (1)
    zinc 27.9 30 12190871 (9), 11309332 (2), 17503403 (1), 20355218 (1) (see all 6)
    polyethylene glycol 12.7 10 15477100 (2)
    lipid 9.12 11 20432169 (2), 10206894 (2), 11425849 (2), 15620688 (1) (see all 7)
    fatty acid 0 3 15477100 (1), 11425849 (1)
    estrogen 0 1 1444749 (1)
    serine 0 1 15595735 (1)

    Search CenterWatch for drugs/clinical trials and news about AZGP1 / ZA2G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AZGP1 gene: 
    NM_001185.3  

    Unigene Cluster for AZGP1:

    Alpha-2-glycoprotein 1, zinc-binding
    Hs.546239  [show with all ESTs]
    Unigene Representative Sequence: BC014470
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483612 ENST00000292401(uc003ush.3) ENST00000419575 ENST00000411734
    ENST00000477251 ENST00000495765

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidAZGP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AZGP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZGP1
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    Sirion Biotech Customized lentivirus for stable overexpression of AZGP1 
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    Primer
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    OriGene qPCR primer pairs and template standards for AZGP1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZGP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZGP1

    Additional mRNA sequence: 

    BC005306.1 BC005908.1 BC014470.1 BC033830.1 D90427.1 M76707.1 X59766.1 

    9 DOTS entries:

    DT.454242  DT.95123268  DT.100819191  DT.95275314  DT.100819194  DT.86855291  DT.95275316  DT.86855292 
    DT.92445589 

    24/320 AceView cDNA sequences (see all 320):

    T50792 CD722675 BM981240 BC043381 CB305376 CK429925 AU099653 BM931193 
    AA449344 AF503615 BM982830 BC005306 CK430006 AA916811 AA622995 H60180 
    CK430249 NM_001185 CD722060 BM977564 CD723049 CA946332 CD722298 BC038207 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:              -           -           -         
    SP2:                                                
    SP3:              -           -                     


    ECgene alternative splicing isoforms for AZGP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AZGP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTCTGGA
    AZGP1 Expression
    About this image


    See AZGP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AZGP1

    SOURCE GeneReport for Unigene cluster: Hs.546239

    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands,
    liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZGP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AZGP1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Azgp11 , 5 alpha-2-glycoprotein 1, zinc1, 5 74.11(n)1
    60.82(a)1
      5 (76.92 cM)5
    120071  NM_013478.21  NP_038506.21 
     1379815215 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 20)
    Uncharacterized protein
    (see all 20)
    41(a)
    41(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    AAWZ02039289(774-2823)
    AAWZ02040156(3915-5955)


    ENSEMBL Gene Tree for AZGP1 (if available)
    TreeFam Gene Tree for AZGP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AZGP1 gene
    MICA2  MICB2  
    18/97 SIMAP similar genes for AZGP1 using alignment to 4 protein entries:     ZA2G_HUMAN (see all proteins) (see all similar genes):
    HLA-B*3531    HLA-B*47RG    HLA-B52    EA2.1    HLA C*    HLA G locus
    HLA-B*15IL    HLA-B*35KM    HLA-B*35SRE    HLA-B*4202    HLA-B*5101 variant    HLA-B52v
    HLA-B*40    HLA-B*51IM    HLA-B*27    HLA -B    HLA-B*1805    HLA-B35

    AZGP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AZGP1
    PGOHUM00000250897 PGOHUM00000250957


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/295 SNPs in AZGP1 are shown (see all 295)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825331041,2
    --99563873(+) TACAAC/TCCCTG 1 -- int10--------
    rs1866328601,2
    --99563949(+) ACACCC/GCTTGT 1 -- int10--------
    rs25278821,2
    C,F,H--99563961(-) CTCTCT/CCAATA 1 -- int122Minor allele frequency- C:0.45NS EA NA WA CSA 2141
    rs102351281,2
    C--99563984(+) ccccaA/Gctggg 1 -- int10--------
    rs1396030421,2
    --99564107(+) AGTAAC/TATCAT 1 -- int10--------
    rs1825645091,2
    --99564118(+) CCTCTC/TCCTTC 1 -- int10--------
    rs1872234911,2
    --99564180(+) CCAAGG/TGAAAG 1 -- int10--------
    rs1497807191,2
    --99564234(+) GGAACA/CATGGC 1 -- int10--------
    rs1128226241,2
    C--99564352(+) CTGTTA/TTGCTA 1 -- ut310--------
    rs1928686851,2
    --99564412(+) TGGGGA/GTGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AZGP1 (99564343 - 99573780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for AZGP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518
    nsv888772CNV Loss21882294
    nsv824234CNV Loss20364138
    nsv824233CNV Loss20364138
    esv32694CNV Loss17666407
    esv23518CNV Gain19812545
    nsv433391CNV Gain18776910

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194460    OMIM disorders: --

    20/28 diseases for AZGP1 (see all 28):    About MalaCards
    clear cell hidradenoma    hidrocystoma    scotoma    hidradenoma
    breast cyst    breast disease    syndactyly    prostate adenocarcinoma
    lung adenocarcinoma    morbid obesity    intrahepatic cholangiocarcinoma    lupus nephritis
    cholangiocarcinoma    nephritis    insulin resistance    prostate cancer
    cervical cancer    obesity    adenocarcinoma    prostatitis


    AZGP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for AZGP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cysts 63 4 9114041 (2), 1828959 (1)
    breast diseases 54.7 2 9114041 (1)
    breast carcinoma 44.6 6 1444749 (2), 8049458 (1), 9114041 (1), 8307568 (1)
    breast cancer 10.5 2 2202419 (1)
    cancer 8.4 9 12190871 (2), 16475792 (1), 15620688 (1), 20198343 (1) (see all 7)
    prostate cancer 0.471 10 11309332 (4), 16598739 (2), 17317883 (2)
    metastasis 0 2 1444749 (1), 16598739 (1)
    tumors 0 13 11309332 (3), 12190871 (2), 2244662 (1), 16598739 (1) (see all 7)
    melanoma 0 2 12190871 (1)

    Human Genome Epidemiology (HuGE) Navigator: AZGP1 (1 document)

    Export disorders for AZGP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AZGP1 gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with AZGP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. (PubMed id 2049092)1, 2, 3, 9 Ueyama H.... Ohkubo I. (1991)
    2. Biochemical characterization and crystalization of human Zn-alpha2- glycoprotein, a soluble class I major histocompatibility complex homolog. (PubMed id 9114041)1, 2, 9 Sanchez L.M.... Bjorkman P.J. (1997)
    3. Crystallographic studies of ligand binding by Zn-alpha2- glycoprotein. (PubMed id 15477100)1, 2, 9 Delker S.L.... Bjorkman P.J. (2004)
    4. Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat- depleting factor related to major histocompatibility complex proteins. (PubMed id 11425849)1, 2, 9 Kennedy M.W.... Sanchez L.M. (2001)
    5. Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules. (PubMed id 10206894)1, 2, 9 Sanchez L.M.... Bjorkman P.J. (1999)
    6. Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein. (PubMed id 8241150)1, 2, 9 Ueyama H.... Ohkubo I. (1993)
    7. Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. (PubMed id 8307568)1, 2, 9 Freije J.P.... Lopez-Otin C. (1993)
    8. Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. (PubMed id 1915885)1, 2, 9 Freije J.P.... Lopez-Otin C. (1991)
    9. Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2 Hassan M.I....Singh T.P. (2008)
    10. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 563 HGNC: 910 AceView: AZGP1 Ensembl:ENSG00000160862 euGenes: HUgn563
    ECgene: AZGP1 H-InvDB: AZGP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AZGP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AZGP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AZGP1 gene:
    Search GeneIP for patents involving AZGP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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