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Aliases for AZGP1 Gene

Aliases for AZGP1 Gene

  • Alpha-2-Glycoprotein 1, Zinc-Binding 2 3 5
  • Zn-Alpha-2-Glycoprotein 3 4
  • Zn-Alpha-2-GP 3 4
  • ZAG 3 4
  • Testicular Tissue Protein Li 227 3
  • Alpha-2-Glycoprotein 1, Zinc 2
  • Alpha-2-Glycoprotein, Zinc 3
  • Zinc-Alpha-2-Glycoprotein 3
  • Zn-Alpha2-Glycoprotein 3
  • ZNGP1 4
  • ZA2G 3

External Ids for AZGP1 Gene

Previous GeneCards Identifiers for AZGP1 Gene

  • GC07M098099
  • GC07M099161
  • GC07M099175
  • GC07M099209
  • GC07M099402
  • GC07M099564
  • GC07M094200

Summaries for AZGP1 Gene

GeneCards Summary for AZGP1 Gene

AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) is a Protein Coding gene. Diseases associated with AZGP1 include Hidrocystoma and Clear Cell Hidradenoma. Among its related pathways are Miscellaneous transport and binding events and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include antigen binding and peptide antigen binding. An important paralog of this gene is HLA-B.

UniProtKB/Swiss-Prot for AZGP1 Gene

  • Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

Gene Wiki entry for AZGP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZGP1 Gene

Genomics for AZGP1 Gene

Regulatory Elements for AZGP1 Gene

Enhancers for AZGP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F099692 1.6 FANTOM5 Ensembl ENCODE 1.8 +281.9 281909 2.7 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 CBX5 KLF13 ZNF263 SP5 NYAP1 PDAP1 MBLAC1 ZKSCAN5 CYP3A5 SAP25 ZSCAN25 ENSG00000244219 CYP3A43 CYP3A4
GH07F099975 0.9 ENCODE 0.8 -0.1 -53 1.0 TBP MLX ZFP64 ARID4B DMAP1 THRB ZNF48 ZSCAN9 RAD21 YY1 TRIM4 AZGP1 AZGP1P1
GH07F099979 0.8 Ensembl 0.8 -4.2 -4220 1.2 DRAP1 CTCF ZFP64 EBF1 ZIC2 RAD21 ZNF7 YY1 GLIS2 POLR2A TRIM4 MBLAC1 CYP3A5 GPC2 AZGP1 AZGP1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AZGP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AZGP1 Gene

Chromosome:
7
Start:
99,966,720 bp from pter
End:
99,976,157 bp from pter
Size:
9,438 bases
Orientation:
Minus strand

Genomic View for AZGP1 Gene

Genes around AZGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AZGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AZGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZGP1 Gene

Proteins for AZGP1 Gene

  • Protein details for AZGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25311-ZA2G_HUMAN
    Recommended name:
    Zinc-alpha-2-glycoprotein
    Protein Accession:
    P25311
    Secondary Accessions:
    • D6W5T8
    • O60386
    • Q5XKQ4
    • Q8N4N0

    Protein attributes for AZGP1 Gene

    Size:
    298 amino acids
    Molecular mass:
    34259 Da
    Quaternary structure:
    • Interacts with PIP.
    SequenceCaution:
    • Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA14417.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA42438.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AZGP1 Gene

neXtProt entry for AZGP1 Gene

Post-translational modifications for AZGP1 Gene

  • N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.
  • Glycosylation at Asn 109, Asn 112, Asn 128, and Asn 259
  • Modification sites at PhosphoSitePlus

Other Protein References for AZGP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AZGP1 Gene

Domains & Families for AZGP1 Gene

Gene Families for AZGP1 Gene

Suggested Antigen Peptide Sequences for AZGP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25311

UniProtKB/Swiss-Prot:

ZA2G_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with AZGP1: view

Function for AZGP1 Gene

Molecular function for AZGP1 Gene

GENATLAS Biochemistry:
zinc alpha-2-glycoprotein 1
UniProtKB/Swiss-Prot Function:
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

Gene Ontology (GO) - Molecular Function for AZGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 18930737
GO:0003823 antigen binding IBA --
GO:0004540 ribonuclease activity NAS 10462714
GO:0005515 protein binding IPI 16237761
GO:0008320 protein transmembrane transporter activity NAS 6896906
genes like me logo Genes that share ontologies with AZGP1: view
genes like me logo Genes that share phenotypes with AZGP1: view

Animal Models for AZGP1 Gene

MGI Knock Outs for AZGP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for AZGP1

miRNA for AZGP1 Gene

miRTarBase miRNAs that target AZGP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AZGP1 Gene

Localization for AZGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZGP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AZGP1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for AZGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005886 plasma membrane IBA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with AZGP1: view

Pathways & Interactions for AZGP1 Gene

genes like me logo Genes that share pathways with AZGP1: view

Pathways by source for AZGP1 Gene

Interacting Proteins for AZGP1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000292401%0d%0a9606.ENSP00000291009%0d%0a9606.ENSP00000274030%0d%0a9606.ENSP00000261023%0d%0a9606.ENSP00000357907%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000292401 P25311-ZA2G_HUMAN for AZGP1 Gene via STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
ABCC1

Gene Ontology (GO) - Biological Process for AZGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis IEP 23580065
GO:0007155 cell adhesion ISS --
GO:0008285 negative regulation of cell proliferation NAS 10462714
GO:0019882 antigen processing and presentation IBA --
genes like me logo Genes that share ontologies with AZGP1: view

No data available for SIGNOR curated interactions for AZGP1 Gene

Drugs & Compounds for AZGP1 Gene

(5) Drugs for AZGP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-acetyl-alpha-neuraminic acid Experimental Pharma Target 0

(4) Additional Compounds for AZGP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
genes like me logo Genes that share compounds with AZGP1: view

Transcripts for AZGP1 Gene

Unigene Clusters for AZGP1 Gene

Alpha-2-glycoprotein 1, zinc-binding:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - - -
SP2:
SP3: - -

Relevant External Links for AZGP1 Gene

GeneLoc Exon Structure for
AZGP1
ECgene alternative splicing isoforms for
AZGP1

Expression for AZGP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AZGP1 Gene

mRNA differential expression in normal tissues according to GTEx for AZGP1 Gene

This gene is overexpressed in Minor Salivary Gland (x16.0), Liver (x14.6), Prostate (x4.5), and Breast - Mammary Tissue (x4.5).

Protein differential expression in normal tissues from HIPED for AZGP1 Gene

This gene is overexpressed in Urine (11.8), Synovial fluid (10.8), Serum (8.0), and Vitreous humor (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AZGP1 Gene



Protein tissue co-expression partners for AZGP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AZGP1 Gene:

AZGP1

SOURCE GeneReport for Unigene cluster for AZGP1 Gene:

Hs.546239

mRNA Expression by UniProt/SwissProt for AZGP1 Gene:

P25311-ZA2G_HUMAN
Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.
genes like me logo Genes that share expression patterns with AZGP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AZGP1 Gene

Orthologs for AZGP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AZGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZGP1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AZGP1 34 35
  • 77.93 (n)
dog
(Canis familiaris)
Mammalia AZGP1 34 35
  • 76.46 (n)
rat
(Rattus norvegicus)
Mammalia Azgp1 34
  • 74.46 (n)
mouse
(Mus musculus)
Mammalia Azgp1 34 16 35
  • 73.72 (n)
oppossum
(Monodelphis domestica)
Mammalia AZGP1 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 32 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
BF1 35
  • 27 (a)
ManyToMany
BFIV21 35
  • 27 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for AZGP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AZGP1 Gene

ENSEMBL:
Gene Tree for AZGP1 (if available)
TreeFam:
Gene Tree for AZGP1 (if available)

Paralogs for AZGP1 Gene

Paralogs for AZGP1 Gene

Pseudogenes.org Pseudogenes for AZGP1 Gene

genes like me logo Genes that share paralogs with AZGP1: view

Variants for AZGP1 Gene

Sequence variations from dbSNP and Humsavar for AZGP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10235128 -- 99,966,361(+) cccca(A/G)ctggg downstream-variant-500B
rs10243303 -- 99,971,469(+) GTGTG(A/G)AGGTG intron-variant
rs111616251 -- 99,971,744(+) CACTG(A/C)CCGTT splice-donor-variant
rs111914925 -- 99,970,255(+) TTTTT(A/T)GTTTT intron-variant
rs112067579 -- 99,968,154(+) GAGTA(C/T)CTTGC splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for AZGP1 Gene

Variant ID Type Subtype PubMed ID
nsv970912 CNV duplication 23825009
nsv824234 CNV loss 20364138
nsv824233 CNV loss 20364138
nsv607930 CNV loss 21841781
nsv469687 CNV loss 16826518
nsv433391 CNV gain 18776910
esv3614287 CNV loss 21293372
esv32694 CNV loss 17666407
esv2734888 CNV deletion 23290073
esv23518 CNV gain 19812545

Variation tolerance for AZGP1 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 31.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AZGP1 Gene

Human Gene Mutation Database (HGMD)
AZGP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AZGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZGP1 Gene

Disorders for AZGP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AZGP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hidrocystoma
  • apocrine cystadenoma
clear cell hidradenoma
  • eccrine acrospiroma
- elite association - COSMIC cancer census association via MalaCards
Search AZGP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AZGP1

Human Genome Epidemiology (HuGE) Navigator
AZGP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AZGP1
genes like me logo Genes that share disorders with AZGP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AZGP1 Gene

Publications for AZGP1 Gene

  1. Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. (PMID: 2049092) Ueyama H. … Ohkubo I. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 22 64
  2. Crystallographic studies of ligand binding by Zn-alpha2- glycoprotein. (PMID: 15477100) Delker S.L. … Bjorkman P.J. (J. Struct. Biol. 2004) 3 4 22 64
  3. Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat- depleting factor related to major histocompatibility complex proteins. (PMID: 11425849) Kennedy M.W. … Sanchez L.M. (J. Biol. Chem. 2001) 3 4 22 64
  4. Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules. (PMID: 10206894) Sanchez L.M. … Bjorkman P.J. (Science 1999) 3 4 22 64
  5. Biochemical characterization and crystallization of human Zn-alpha2- glycoprotein, a soluble class I major histocompatibility complex homolog. (PMID: 9114041) Sanchez L.M. … Bjorkman P.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 22 64

Products for AZGP1 Gene

Sources for AZGP1 Gene

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