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Aliases for AZGP1 Gene

Aliases for AZGP1 Gene

  • Alpha-2-Glycoprotein 1, Zinc-Binding 2 3
  • ZAG 3 4 6
  • Zn-Alpha-2-Glycoprotein 3 4
  • Zn-Alpha-2-GP 3 4
  • Alpha-2-Glycoprotein 1, Zinc 2
  • Alpha-2-Glycoprotein, Zinc 3
  • Zinc-Alpha-2-Glycoprotein 3
  • Zn-Alpha2-Glycoprotein 3
  • ZNGP1 4
  • ZA2G 3

External Ids for AZGP1 Gene

Previous GeneCards Identifiers for AZGP1 Gene

  • GC07M098099
  • GC07M099161
  • GC07M099175
  • GC07M099209
  • GC07M099402
  • GC07M099564
  • GC07M094200

Summaries for AZGP1 Gene

GeneCards Summary for AZGP1 Gene

AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) is a Protein Coding gene. Diseases associated with AZGP1 include prostate cancer. GO annotations related to this gene include antigen binding and ribonuclease activity. An important paralog of this gene is MR1.

UniProtKB/Swiss-Prot for AZGP1 Gene

  • Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids

Gene Wiki entry for AZGP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZGP1 Gene

Genomics for AZGP1 Gene

Regulatory Elements for AZGP1 Gene

Genomic Location for AZGP1 Gene

Start:
99,966,720 bp from pter
End:
99,976,157 bp from pter
Size:
9,438 bases
Orientation:
Minus strand

Genomic View for AZGP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AZGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZGP1 Gene

Proteins for AZGP1 Gene

  • Protein details for AZGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25311-ZA2G_HUMAN
    Recommended name:
    Zinc-alpha-2-glycoprotein
    Protein Accession:
    P25311
    Secondary Accessions:
    • D6W5T8
    • O60386
    • Q5XKQ4
    • Q8N4N0

    Protein attributes for AZGP1 Gene

    Size:
    298 amino acids
    Molecular mass:
    34259 Da
    Quaternary structure:
    • Interacts with PIP.
    SequenceCaution:
    • Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA14417.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA42438.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AZGP1 Gene

neXtProt entry for AZGP1 Gene

Proteomics data for AZGP1 Gene at MOPED

Post-translational modifications for AZGP1 Gene

  • N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.
  • Glycosylation at Asn109, Asn112, Asn128, and Asn259
  • Modification sites at PhosphoSitePlus

Other Protein References for AZGP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AZGP1 Gene

Domains for AZGP1 Gene

Gene Families for AZGP1 Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing

Suggested Antigen Peptide Sequences for AZGP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25311

UniProtKB/Swiss-Prot:

ZA2G_HUMAN :
  • P25311
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with AZGP1: view

Function for AZGP1 Gene

Molecular function for AZGP1 Gene

GENATLAS Biochemistry: zinc alpha-2-glycoprotein 1
UniProtKB/Swiss-Prot Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids

Gene Ontology (GO) - Molecular Function for AZGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 18930737
GO:0003823 antigen binding IBA --
GO:0004540 ribonuclease activity NAS 10462714
GO:0005515 protein binding IPI 16237761
GO:0008320 protein transmembrane transporter activity NAS 6896906
genes like me logo Genes that share ontologies with AZGP1: view
genes like me logo Genes that share phenotypes with AZGP1: view

Animal Models for AZGP1 Gene

MGI Knock Outs for AZGP1:

Animal Model Products

CRISPR Products

miRNA for AZGP1 Gene

miRTarBase miRNAs that target AZGP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AZGP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AZGP1 Gene

Localization for AZGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZGP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AZGP1 Gene COMPARTMENTS Subcellular localization image for AZGP1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AZGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005886 plasma membrane IBA --
GO:0042612 MHC class I protein complex IEA --
genes like me logo Genes that share ontologies with AZGP1: view

Pathways for AZGP1 Gene

SuperPathways for AZGP1 Gene

No Data Available

Interacting Proteins for AZGP1 Gene

Gene Ontology (GO) - Biological Process for AZGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis IEP 23580065
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with AZGP1: view

No data available for Pathways by source for AZGP1 Gene

Compounds for AZGP1 Gene

(2) Drugbank Compounds for AZGP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
O-Sialic Acid
target

(7) Novoseek inferred chemical compound relationships for AZGP1 Gene

Compound -log(P) Hits PubMed IDs
polyacrylamide 44.7 2
zinc 27.9 15
polyethylene glycol 12.7 2
lipid 9.12 10
fatty acid 0 2
genes like me logo Genes that share compounds with AZGP1: view

Transcripts for AZGP1 Gene

mRNA/cDNA for AZGP1 Gene

Unigene Clusters for AZGP1 Gene

Alpha-2-glycoprotein 1, zinc-binding:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AZGP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - - -
SP2:
SP3: - -

Relevant External Links for AZGP1 Gene

GeneLoc Exon Structure for
AZGP1
ECgene alternative splicing isoforms for
AZGP1

Expression for AZGP1 Gene

mRNA expression in normal human tissues for AZGP1 Gene

mRNA differential expression in normal tissues according to GTEx for AZGP1 Gene

This gene is overexpressed in Minor Salivary Gland (16.0), Liver (14.6), Prostate (4.5), and Breast - Mammary Tissue (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AZGP1 Gene

SOURCE GeneReport for Unigene cluster for AZGP1 Gene Hs.546239

mRNA Expression by UniProt/SwissProt for AZGP1 Gene

P25311-ZA2G_HUMAN
Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver
genes like me logo Genes that share expressions with AZGP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AZGP1 Gene

Orthologs for AZGP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AZGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZGP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AZGP1 35
  • 77.93 (n)
  • 68.94 (a)
AZGP1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AZGP1 35
  • 76.46 (n)
  • 61.49 (a)
AZGP1 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Azgp1 35
  • 73.72 (n)
  • 60.41 (a)
Azgp1 16
Azgp1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AZGP1 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Azgp1 35
  • 74.46 (n)
  • 61.51 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
BF1 36
  • 27 (a)
ManyToMany
BFIV21 36
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for AZGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AZGP1 Gene

ENSEMBL:
Gene Tree for AZGP1 (if available)
TreeFam:
Gene Tree for AZGP1 (if available)

Paralogs for AZGP1 Gene

Paralogs for AZGP1 Gene

Pseudogenes.org Pseudogenes for AZGP1 Gene

genes like me logo Genes that share paralogs with AZGP1: view

Variants for AZGP1 Gene

Sequence variations from dbSNP and Humsavar for AZGP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1804900 -- 99,966,902(-) TCCAC(A/G)AGGCC utr-variant-3-prime
rs1804901 -- 99,966,906(-) TGGAT(C/T)CACAA utr-variant-3-prime
rs1804902 -- 99,966,890(-) GAGGA(A/G)CAGTG utr-variant-3-prime
rs1804903 -- 99,966,939(-) ATGTG(G/T)GAGCT utr-variant-3-prime
rs1894235 -- 99,971,939(-) TTTCA(A/G)GCCCT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for AZGP1 Gene

Variant ID Type Subtype PubMed ID
nsv888772 CNV Loss 21882294
nsv824233 CNV Loss 20364138
nsv824234 CNV Loss 20364138
nsv433391 CNV Gain 18776910
esv23518 CNV Gain 19812545
esv32694 CNV Loss 17666407
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073

Relevant External Links for AZGP1 Gene

HapMap Linkage Disequilibrium report
AZGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZGP1 Gene

Disorders for AZGP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AZGP1 Gene including...

Search for AZGP1 Gene in MalaCards »

(9) Novoseek inferred disease relationships for AZGP1 Gene

Disease -log(P) Hits PubMed IDs
breast cysts 63 3
breast diseases 54.7 1
breast carcinoma 44.6 5
breast cancer 10.5 1
cancer 8.4 8

Relevant External Links for AZGP1

Human Genome Epidemiology (HuGE) Navigator
AZGP1
genes like me logo Genes that share disorders with AZGP1: view

No data available for UniProtKB/Swiss-Prot for AZGP1 Gene

Publications for AZGP1 Gene

  1. Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. (PMID: 2049092) Ueyama H. … Ohkubo I. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 23
  2. Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein. (PMID: 8241150) Ueyama H. … Ohkubo I. (Biochemistry 1993) 3 4 23
  3. Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. (PMID: 8307568) Freije J.P. … Lopez-Otin C. (Genomics 1993) 3 4 23
  4. Biochemical characterization and crystallization of human Zn-alpha2- glycoprotein, a soluble class I major histocompatibility complex homolog. (PMID: 9114041) Sanchez L.M. … Bjorkman P.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  5. Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. (PMID: 1915885) Freije J.P. … Lopez-Otin C. (FEBS Lett. 1991) 3 4 23

Products for AZGP1 Gene

Sources for AZGP1 Gene

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