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Aliases & Descriptions for AZGP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ZA2G 1, 2 | | ZAG 1, 2, 3, 5 | | ZNGP1 3 | | Zn-alpha-2-GP 3 | | Zn-alpha-2-glycoprotein 3 | | Zn-alpha2-glycoprotein 2 |
| | | Descriptions |
|---|
| Alpha-2-glycoprotein, zinc 2 | | alpha-2-glycoprotein 1, zinc 1, 2 | | alpha-2-glycoprotein 1, zinc-binding 2 |
|
| | Search outside databases for aliases for AZGP1 genePrevious GC identifers: GC07M098099 GC07M099161 GC07M099175 GC07M099209 |
Summaries for AZGP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acidsGene Wiki entry for AZGP1 |
Genomic Location for AZGP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AZGP1 gene 
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1AZGP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M099402:
(about GC identifiers)
Start:
|
99,402,286 bp from pter |
End:
|
99,411,623 bp from pter |
Size:
|
9,338 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 98,924,486-98,933,820 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079595.2
| Proteins for AZGP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311 (See
protein sequence)Recommended Name: Zinc-alpha-2-glycoprotein precursor Size: 295 amino acids; 33872 Da
Subunit: Interacts with PIP
Subcellular location: Secreted
PDB structures from and Proteopedia :1T7V (3D)
 1T7W (3D)
 1T7X (3D)
 1T7Y (3D)
 1T7Z (3D)
 1T80 (3D)
 1ZAG (3D)
 3ES6 (3D)
 
Secondary accessions: O60386 Q5XKQ4 Q8N4N0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001176.1
ENSEMBL proteins: ENSP00000292401
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AZGP1: Assays for AZGP1: | Protein
Domains/ Families for AZGP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P25311
ProtoNet protein and cluster: P25311 2 Blocks protein families: IPB001039 MHC class I signature IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain | Gene Function for AZGP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001185
Applied Biosystems Silencer® siRNAs for AZGP1
Sigma-Aldrich siRNA for AZGP1  Sigma-Aldrich shRNA for AZGP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001185                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001185                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001185 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001185
UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acidsGenatlas biochemistry entry for AZGP1:zinc alpha-2-glycoprotein 11 MGI phenotypic allele for Azgp1 (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AZGP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for AZGP1 (ENSP000002924013) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for AZGP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AZGP1 4 Novoseek chemical compound relationships for AZGP1 gene
About this table
|
Transcripts for AZGP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001185
Sigma-Aldrich siRNA for AZGP1  Sigma-Aldrich shRNA for AZGP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001185 REFSEQ mRNAs for AZGP1 gene: NM_001185.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001185               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001185                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001185                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001185  Additional cDNA sequence: BC005306.1 BC005908.1 BC014470.1 BC033830.1 D90427.1 M76707.1 X59766.1 9 DOTS entries: DT.454242 DT.95123268 DT.100819191 DT.95275314 DT.86855291 DT.100819194 DT.95275316 DT.86855292 DT.92445589 24/320 AceView cDNA sequences (see all 320
):AU099653 CD723505 CD722298 CD722018 BC014470 AU076706 CD722675 AA449344 AY297109 BX281800 CD722282 H21514 AF503615 BM977564 T74702 CD721785 CD724111 CB122300 BM931193 BM982830 CD722925 CA946357 CK430854 AA074992
highest scoring ESTs for AZGP1:X59766 AA143598 AA344600 AA345762 AA507153 AA583037 AU099653 AV695243 BC005306 BC005908 Unigene Cluster for AZGP1: Alpha-2-glycoprotein 1, zinc-binding Hs.546239 [show with all ESTs]Unigene Representative Sequence: BC014470
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | |
| SP1: | |   | |   | - |   | |   | - |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AZGP1
1 Ensembl transcript including schematic representation: ENST00000292401
|
Expression for AZGP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AZGP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AZGP1
1 / 2 / 3 5 probe-sets matching AZGP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGACTCTGGA
SOURCE GeneReport for Unigene cluster: Hs.546239
Expression variation in blood from EXPOLDB for AZGP1 UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver |
Orthologs for AZGP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AZGP1 gene from 5 species
About this table Species with no ortholog for AZGP1
ENSEMBL Gene Tree for AZGP1 | Paralogs for AZGP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AZGP1 gene
- ENSG000002045202 FCGRT2 HFE2 ENSG000002045162 AZGP1P22
|
SNPs/Variants for AZGP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AZGP1 (up to first 250kb)
|
Disorders & Mutations for AZGP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 194460
9 Novoseek disease relationships for AZGP1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cysts |
63.96 |
4 |
9114041 (2), 1828959 (1) |
| breast diseases |
56.37 |
2 |
9114041 (1) |
| breast carcinoma |
46.46 |
6 |
1444749 (2), 8049458 (1), 9114041 (1), 8307568 (1) |
| breast cancer |
13.36 |
2 |
2202419 (1) |
| cancer |
8.25 |
8 |
12190871 (2), 16475792 (1), 15620688 (1), 15449322 (1) (see all 6) |
| prostate cancer |
3.54 |
10 |
11309332 (4), 16598739 (2), 17317883 (2) |
| melanoma |
0.00 |
2 |
12190871 (1) |
| tumors |
0.00 |
13 |
11309332 (3), 12190871 (2), 2244662 (1), 16598739 (1) (see all 7) |
| metastasis |
0.00 |
2 |
1444749 (1), 16598739 (1) |
About this table
|
Medical News for AZGP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AZGP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/80 PubMed articles for AZGP1 gene (see all 80
):- Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. (PubMed id 2049092)1, 2, 3, 4 Ueyama H.... Ohkubo I. (1991)
- Biochemical characterization and crystalization of human Zn-alpha2- glycoprotein, a soluble class I major histocompatibility complex homolog. (PubMed id 9114041)1, 3, 4 Sanchez L.M.... Bjorkman P.J. (1997)
- Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein. (PubMed id 15477100)1, 3, 4 Delker S.L....Bjorkman P.J. (2004)
- Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat- depleting factor related to major histocompatibility complex proteins. (PubMed id 11425849)1, 3, 4 Kennedy M.W.... Sanchez L.M. (2001)
- Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules. (PubMed id 10206894)1, 3, 4 Sanchez L.M.... Bjorkman P.J. (1999)
- Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein. (PubMed id 8241150)1, 3, 4 Ueyama H.... Ohkubo I. (1993)
- Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. (PubMed id 8307568)1, 3, 4 Freije J.P....Lopez-Otin C. (1993)
- Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. (PubMed id 1915885)1, 3, 4 Freije J.P.... Lopez-Otin C. (1991)
- Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)3, 4 Hassan M.I....Singh T.P. (2008)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)3, 4 Ramachandran P....Loo J.A. (2006)
|
Search for AZGP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AZGP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AZGP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AZGP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AZGP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AZGP1:

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Incremental update: 13 Oct 2009
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