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AZGP1 Gene

protein-coding   GIFtS: 59
GCID: GC07M099564

Alpha-2-Glycoprotein 1, Zinc-Binding

(Previous names: alpha-2-glycoprotein 1, zinc)
  See AZGP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alpha-2-Glycoprotein 1, Zinc-Binding1 2     zinc-alpha-2-glycoprotein2
ZAG2 3 5     zn-alpha-2-GP2
Alpha-2-Glycoprotein 1, Zinc1     zn-alpha-2-glycoprotein2
ZA2G2     ZNGP13
Zn-alpha2-glycoprotein2     Zn-alpha-2-GP3
Alpha-2-Glycoprotein, Zinc2     Zn-alpha-2-glycoprotein3

External Ids:    HGNC: 9101   Entrez Gene: 5632   Ensembl: ENSG000001608627   OMIM: 1944605   UniProtKB: P253113   

Export aliases for AZGP1 gene to outside databases

Previous GC identifers: GC07M098099 GC07M099161 GC07M099175 GC07M099209 GC07M099402 GC07M094200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AZGP1 Gene:
AZGP1 (alpha-2-glycoprotein 1, zinc-binding) is a protein-coding gene. Diseases associated with AZGP1 include prostate cancer. GO annotations related to this gene include ribonuclease activity and antigen binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some
advanced cancers. May bind polyunsaturated fatty acids

Gene Wiki entry for AZGP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the AZGP1 gene promoter:
         Max1   NF-1   Elk-1   NCX/Ncx   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAZGP1 promoter sequence
   Search Chromatin IP Primers for AZGP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AZGP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

AZGP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AZGP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099564:  view genomic region     (about GC identifiers)

Start:
99,564,343 bp from pter      End:
99,573,780 bp from pter
Size:
9,438 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,924,486-98,933,868     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311 (See protein sequence)
Recommended Name: Zinc-alpha-2-glycoprotein precursor  
Size: 298 amino acids; 34259 Da
Subunit: Interacts with PIP
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA14417.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA42438.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for AZGP1 (see all 8):
1T7V (3D)        1T7W (3D)        1T7X (3D)        1T7Y (3D)        1T7Z (3D)        1T80 (3D)    
Secondary accessions: D6W5T8 O60386 Q5XKQ4 Q8N4N0

Explore the universe of human proteins at neXtProt for AZGP1: NX_P25311

Explore proteomics data for AZGP1 at MOPED

Post-translational modifications: 

  • N-glycosylated. N-glycan at Asn-128: Hex5HexNAc41
  • Glycosylation2 at Asn109, Asn112, Asn128, Asn259
  • Modification sites at PhosphoSitePlus

  • See AZGP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001176.1  
    ENSEMBL proteins: 
     ENSP00000292401   ENSP00000389942   ENSP00000396093  

    AZGP1 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for AZGP1
    Sino Biological Cell Lysate for AZGP1
    ProSpec Recombinant Protein for AZGP1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AZGP1 

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    Search eBioscience for ELISAs for AZGP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P25311

    ProtoNet protein and cluster: P25311

    2 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with AZGP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZA2G_HUMAN, P25311
    Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some
    advanced cancers. May bind polyunsaturated fatty acids

         Genatlas biochemistry entry for AZGP1:
    zinc alpha-2-glycoprotein 1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI18930737
    GO:0003823antigen binding IBA--
    GO:0004540ribonuclease activity NAS10462714
    GO:0005515protein binding ----
    GO:0008320protein transmembrane transporter activity NAS6896906
         
    Find genes that share ontologies with AZGP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AZGP1:
     Synthetic lethal with imatinib 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Azgp1):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with AZGP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AZGP1: Azgp1tm1Lex Azgp1tm1.1Sbah

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AZGP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AZGP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AZGP1

    miRNA
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    miRTarBase miRNAs that target AZGP1:
    hsa-mir-128-3p (MIRT022028)

    Block miRNA regulation of human, mouse, rat AZGP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AZGP1
    SwitchGear 3'UTR luciferase reporter plasmidAZGP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AZGP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZGP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZA2G_HUMAN, P25311: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane IBA--
    GO:0042612MHC class I protein complex IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with AZGP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AZGP1
    Interactions:

        Search GeneGlobe Interaction Network for AZGP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AZGP1 (P253113 ENSP000002924014) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP53Q70EK83, ENSP000002740304I2D: score=2 STRING: ENSP00000274030
    ITGAVP067563, ENSP000002610234I2D: score=1 STRING: ENSP00000261023
    APCP250543I2D: score=2 
    ATG101Q9BSB43I2D: score=1 
    GOSR1O952493I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA--
    GO:0001895retina homeostasis IEP--
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I IEA--
    GO:0006955immune response IEA--

    Find genes that share ontologies with AZGP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AZGP1 (ZA2G)

    2 DrugBank Compounds for AZGP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----
    O-Sialic Acid-- --target----

    7 Novoseek inferred chemical compound relationships for AZGP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyacrylamide 44.7 3 1592045 (1), 2265857 (1)
    zinc 27.9 30 12190871 (9), 11309332 (2), 17503403 (1), 20355218 (1) (see all 6)
    polyethylene glycol 12.7 10 15477100 (2)
    lipid 9.12 11 20432169 (2), 10206894 (2), 11425849 (2), 15620688 (1) (see all 7)
    fatty acid 0 3 15477100 (1), 11425849 (1)
    estrogen 0 1 1444749 (1)
    serine 0 1 15595735 (1)



    Find genes that share compounds with AZGP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AZGP1 gene: 
    NM_001185.3  

    Unigene Cluster for AZGP1:

    Alpha-2-glycoprotein 1, zinc-binding
    Hs.546239  [show with all ESTs]
    Unigene Representative Sequence: BC014470
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483612 ENST00000292401(uc003ush.3) ENST00000419575 ENST00000411734
    ENST00000477251 ENST00000495765
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AZGP1
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      QuantiTect SYBR Green Assays in human, mouse, rat AZGP1
      QuantiFast Probe-based Assays in human, mouse, rat AZGP1

    Additional mRNA sequence: 

    BC005306.1 BC005908.1 BC014470.1 BC033830.1 D90427.1 M76707.1 X59766.1 

    9 DOTS entries:

    DT.454242  DT.95123268  DT.100819191  DT.95275314  DT.100819194  DT.86855291  DT.95275316  DT.86855292 
    DT.92445589 

    Selected AceView cDNA sequences (see all 320):

    CD721785 CB122300 AY297109 CK429925 AW015837 CK430854 AA622995 CK431134 
    AA449344 CD722298 BC043381 T74702 CD722869 BM981240 CD722675 CD723049 
    CK430006 AU076706 AA916811 CD722925 CD722282 CD722721 BM795361 BX281800 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:              -           -           -         
    SP2:                                                
    SP3:              -           -                     


    ECgene alternative splicing isoforms for AZGP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AZGP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTCTGGA
    AZGP1 Expression
    About this image

    AZGP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AZGP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546239

    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands,
    liver

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AZGP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Azgp11 , 5 alpha-2-glycoprotein 1, zinc1, 5 73.72(n)1
    60.41(a)1
      5 (76.92 cM)5
    120071  NM_013478.21  NP_038506.21 
     1379815215 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 17)
    Uncharacterized protein
    (see all 17)
    32(a)
    30(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    JH375197.1(5805-7031)
    JH375207.1(19595-21254)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 20)
    Uncharacterized protein
    (see all 20)
    41(a)
    41(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    AAWZ02039289(774-2823)
    AAWZ02040156(3915-5955)


    ENSEMBL Gene Tree for AZGP1 (if available)
    TreeFam Gene Tree for AZGP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AZGP1 gene
    HLA-F2  MR12  FCGRT2  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  
    HLA-G2  
    Selected SIMAP similar genes for AZGP1 using alignment to 4 protein entries:     ZA2G_HUMAN (see all proteins) (see all similar genes):
    HLA-B*3531    HLA-B*47RG    HLA-B52    EA2.1    HLA C*    HLA G locus
    HLA-B*15IL    HLA-B*35KM    HLA-B*35SRE    HLA-B*4202    HLA-B*5101 variant    HLA-B52v
    HLA-B*40    HLA-B*51IM    HLA-B*27    HLA -B    HLA-B*1805    HLA-B35

    Find genes that share paralogs with AZGP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for AZGP1
    PGOHUM00000250897 PGOHUM00000250957


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AZGP1 (see all 295)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825331041,2
    --99563873(+) TACAAC/TCCCTG 1 -- int10--------
    rs1866328601,2
    --99563949(+) ACACCC/GCTTGT 1 -- int10--------
    rs25278821,2
    C,F,H--99563961(-) CTCTCT/CCAATA 1 -- int122Minor allele frequency- C:0.45NS EA NA WA CSA 2141
    rs102351281,2
    C--99563984(+) ccccaA/Gctggg 1 -- int10--------
    rs1396030421,2
    --99564107(+) AGTAAC/TATCAT 1 -- int10--------
    rs1825645091,2
    --99564118(+) CCTCTC/TCCTTC 1 -- int10--------
    rs1872234911,2
    --99564180(+) CCAAGG/TGAAAG 1 -- int10--------
    rs1497807191,2
    --99564234(+) GGAACA/CATGGC 1 -- int10--------
    rs1128226241,2
    C--99564352(+) CTGTTA/TTGCTA 1 -- ut310--------
    rs1928686851,2
    --99564412(+) TGGGGA/GTGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for AZGP1 (99564343 - 99573780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for AZGP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518
    nsv888772CNV Loss21882294
    nsv824234CNV Loss20364138
    nsv824233CNV Loss20364138
    esv32694CNV Loss17666407
    esv23518CNV Gain19812545
    nsv433391CNV Gain18776910

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194460    OMIM disorders: --

    1 disease for AZGP1:    
    About MalaCards
    prostate cancer


    Find genes that share disorders with AZGP1           About GenesLikeMe

    9 Novoseek inferred disease relationships for AZGP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cysts 63 4 9114041 (2), 1828959 (1)
    breast diseases 54.7 2 9114041 (1)
    breast carcinoma 44.6 6 1444749 (2), 8049458 (1), 9114041 (1), 8307568 (1)
    breast cancer 10.5 2 2202419 (1)
    cancer 8.4 9 12190871 (2), 16475792 (1), 15620688 (1), 20198343 (1) (see all 7)
    prostate cancer 0.471 10 11309332 (4), 16598739 (2), 17317883 (2)
    metastasis 0 2 1444749 (1), 16598739 (1)
    tumors 0 13 11309332 (3), 12190871 (2), 2244662 (1), 16598739 (1) (see all 7)
    melanoma 0 2 12190871 (1)

    Human Genome Epidemiology (HuGE) Navigator: AZGP1 (1 document)

    Export disorders for AZGP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AZGP1 gene, integrated from 10 sources (see all 128):
    (articles sorted by number of sources associating them with AZGP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene. (PubMed id 2049092)1, 2, 3, 9 Ueyama H.... Ohkubo I. (Biochem. Biophys. Res. Commun. 1991)
    2. Biochemical characterization and crystallization of human Zn-alpha2- glycoprotein, a soluble class I major histocompatibility complex homolog. (PubMed id 9114041)1, 2, 9 Sanchez L.M.... Bjorkman P.J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Crystallographic studies of ligand binding by Zn-alpha2- glycoprotein. (PubMed id 15477100)1, 2, 9 Delker S.L.... Bjorkman P.J. (J. Struct. Biol. 2004)
    4. Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat- depleting factor related to major histocompatibility complex proteins. (PubMed id 11425849)1, 2, 9 Kennedy M.W.... Sanchez L.M. (J. Biol. Chem. 2001)
    5. Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules. (PubMed id 10206894)1, 2, 9 Sanchez L.M.... Bjorkman P.J. (Science 1999)
    6. Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein. (PubMed id 8241150)1, 2, 9 Ueyama H.... Ohkubo I. (Biochemistry 1993)
    7. Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes. (PubMed id 8307568)1, 2, 9 Freije J.P.... Lopez-Otin C. (Genomics 1993)
    8. Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues. (PubMed id 1915885)1, 2, 9 Freije J.P.... Lopez-Otin C. (FEBS Lett. 1991)
    9. Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2 Hassan M.I....Singh T.P. (J. Mol. Biol. 2008)
    10. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 563 HGNC: 910 AceView: AZGP1 Ensembl:ENSG00000160862 euGenes: HUgn563
    ECgene: AZGP1 H-InvDB: AZGP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AZGP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AZGP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AZGP1 gene:
    Search GeneIP for patents involving AZGP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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