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AZGP1 Gene

protein-coding   GIFtS: 60

GC07M099402
alpha-2-glycoprotein 1, zinc-binding
(Previous names: alpha-2-glycoprotein 1, zinc )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ZA2G 1, 2
ZAG 1, 2, 3, 5
ZNGP1 3
Zn-alpha-2-GP 3
Zn-alpha-2-glycoprotein 3
Zn-alpha2-glycoprotein 2
Descriptions
Alpha-2-glycoprotein, zinc 2
alpha-2-glycoprotein 1, zinc 1, 2
alpha-2-glycoprotein 1, zinc-binding 2
External Ids
HGNC: 9101
Entrez Gene: 5632
UniProtKB: P253113
Ensembl: ENSG000001608627
Search outside databases for aliases for AZGP1 gene

Previous GC identifers: GC07M098099 GC07M099161 GC07M099175 GC07M099209

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated
with some advanced cancers. May bind polyunsaturated fatty acids

Gene Wiki entry for AZGP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AZGP1 gene  

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

AZGP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099402:     (about GC identifiers)

Start:
99,402,286 bp from pter
End:
99,411,623 bp from pter
Size:
9,338 bases
Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,924,486-98,933,820     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079595.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311 (See protein sequence)
Recommended Name: Zinc-alpha-2-glycoprotein precursor  
Size: 295 amino acids; 33872 Da
Subunit: Interacts with PIP
Subcellular location: Secreted
PDB structures from and Proteopedia :
1T7V (3D)    1T7W (3D)    1T7X (3D)    1T7Y (3D)    1T7Z (3D)    1T80 (3D)    1ZAG (3D)    3ES6 (3D)    
Secondary accessions: O60386 Q5XKQ4 Q8N4N0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001176.1  

    ENSEMBL proteins: 
    ENSP00000292401 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Zinc Alpha 2 Glycoprotein)
    Human Recombinant Proteins from Abnova (AZGP1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region NAS14718574
    GO:0016020 membrane IEA--
    GO:0042612 MHC class I protein complex IEA--
    About this table

    Antibodies for AZGP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for AZGP1
    R&D Systems Antibodies for AZGP1 (ZAG)
    Antibodies from Abcam (Zinc Alpha 2 Glycoprotein), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (AZGP1)
    Novus Biologicals Antibodies for AZGP1

    Assays for AZGP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR007110 Ig-like
     IPR003006 Ig/MHC_CS
     IPR011161 MHC_I-like_Ag-recog
     IPR001039 MHC_I_a_a1/a2
     IPR013783 Ig-like_fold


       GeneDecks  AZGP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P25311

    ProtoNet protein and cluster: P25311

    2 Blocks protein families:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AZGP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AZGP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001185

                  Applied Biosystems Silencer® siRNAs for AZGP1

                  Sigma-Aldrich siRNA for AZGP1  
                         Sigma-Aldrich shRNA for AZGP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for AZGP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001185
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001185
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001185 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001185

    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Function: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated
    with some advanced cancers. May bind polyunsaturated fatty acids

    Genatlas biochemistry entry for AZGP1:
    zinc alpha-2-glycoprotein 1
    1 MGI phenotypic allele for Azgp1 (no phenotypes)

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004540 ribonuclease activity NAS10462714
    GO:0005504 fatty acid binding NAS10206894
    GO:0008320 protein transmembrane transporter activity NAS6896906
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for AZGP1 (Maps provided by GeneGo):
     IFN-gamma/IL-10 signaling in keratinocytes via JAK/STAT pathway

       GeneDecks  AZGP1 for the pathways selected above  
    About GeneDecksing


    4 Interacting proteins for AZGP1 (ENSP000002924013) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIPENSP000002910093STRING (score=.962)
    UCP1ENSP000002629993STRING (score=.888)
    CYCSENSP000003077863STRING (score=.844)
    KLK3ENSP000003141513STRING (score=.726)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response IEA--
    GO:0007155 cell adhesion IDA9813179
    GO:0008285 negative regulation of cell proliferation NAS10462714
    GO:0016042 lipid catabolic process NAS10206894
    GO:0019882 antigen processing and presentation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for AZGP1
    4 Novoseek chemical compound relationships for AZGP1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyacrylamide 37.09 3 1592045 (1), 2265857 (1)
    zinc 24.62 29 12190871 (9), 11309332 (2), 17503403 (1), 18978557 (1) (see all 5)
    lipid 6.56 9 10206894 (2), 11425849 (2), 15620688 (1), 16598739 (1) (see all 6)
    fatty acid 0.00 3 15477100 (1), 11425849 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (AZGP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (AZGP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001185

                  Sigma-Aldrich siRNA for AZGP1  
                         Sigma-Aldrich shRNA for AZGP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001185  

    REFSEQ mRNAs for AZGP1 gene: 

    NM_001185.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001185  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001185
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001185
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001185 

    Additional cDNA sequence: 

    BC005306.1 BC005908.1 BC014470.1 BC033830.1 D90427.1 M76707.1 X59766.1 

    9 DOTS entries:

    DT.454242  DT.95123268  DT.100819191  DT.95275314  DT.86855291  DT.100819194  DT.95275316  DT.86855292 
    DT.92445589 

    24/320 AceView cDNA sequences (see all 320 ):

    AU099653 CD723505 CD722298 CD722018 BC014470 AU076706 CD722675 AA449344 
    AY297109 BX281800 CD722282 H21514 AF503615 BM977564 T74702 CD721785 
    CD724111 CB122300 BM931193 BM982830 CD722925 CA946357 CK430854 AA074992 

    highest scoring ESTs for AZGP1:

    X59766 AA143598 AA344600 AA345762 AA507153 AA583037 AU099653 AV695243 BC005306 BC005908 

    Unigene Cluster for AZGP1:

    Alpha-2-glycoprotein 1, zinc-binding
    Hs.546239  [show with all ESTs]
    Unigene Representative Sequence: BC014470


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AZGP1

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:              -           -           -         
    SP2:                                                
    SP3:              -           -                     

    About this scheme

    ECgene alternative splicing isoforms for AZGP1

    1 Ensembl transcript including schematic representation:
    ENST00000292401  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    AZGP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for AZGP1

    1 / 2 / 3

    5 probe-sets matching AZGP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35834_at2, 3 U95-A 3 1.00 0.96 1.00 1.00 X59766 1.00 1.00 1.00 1

    209309_at2, 3 U133-A 3 1.00 0.82 -- -- D90427 0.80 1.00 0.91 1

    217014_s_at2 U133-A 4 1.00 0.30 -- -- -- -- -- -- --

    209309_at2 U133Plus2 3 1.00 0.82 -- -- -- -- -- -- --

    217014_s_at2 U133Plus2 4 1.00 0.30 -- -- -- -- -- -- --
    GeneDecks  AZGP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGACTCTGGA

    SOURCE GeneReport for Unigene cluster: Hs.546239

    Expression variation in blood from EXPOLDB for AZGP1

    UniProtKB/Swiss-Prot: ZA2G_HUMAN, P25311
    Tissue specificity: Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various
    human glands, liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for AZGP1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    AZGP11   -- alpha-2-glycoprotein 1, zinc-binding 76.46(n)
    61.49(a)
    479739  XM_536867.2  XP_536867.2 
    chimpanzee
    (Pan troglodytes)
    AZGP11   -- alpha-2-glycoprotein 1, zinc-binding 99.44(n)
    100(a)
    737709  XM_001143820.1  XP_001143820.1 
    cow
    (Bos taurus)
    AZGP11   -- alpha-2-glycoprotein 1, zinc-binding 77.93(n)
    68.94(a)
    508800  NM_001034331.1  NP_001029503.1 
    rat
    (Rattus norvegicus)
    Azgp11   -- alpha-2-glycoprotein 1, zinc-binding 74.68(n)
    61.86(a)
    25294  NM_012826.1  NP_036958.1 
    mouse
    (Mus musculus)
    Azgp11, 5 5 (78.00 cM)5
    alpha-2-glycoprotein 1, zinc1, 5 74.34(n)1
    61.17(a)1
    120071  NM_013478.11  NP_038506.11 
     AF2816585  AK0050515  (see all 13)
    About this table        Species with no ortholog for AZGP1

    ENSEMBL Gene Tree for AZGP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for AZGP1 gene
    ENSG000002045202  FCGRT2  HFE2  ENSG000002045162  AZGP1P22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/57 NCBI SNPs in AZGP1 are shown (see all 57 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 7)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs22830171,2
    C,F99412694(+) TGCCCA/GGCCTC 1 -- ng310--------
    --
    rs22476071,2
    A,C99412674(+) tttacA/Tagtgt 1 -- ng310--------
    --
    rs115414431,2
    H99407446(-) AAGACA/GGGAAG 1 R/G mis1 ese34Minor allele frequency- G:0.00EU EA WA 406
    --
    rs37354501,2
    C99403952(-) GAGATC/G/TGAGAA 2 I/M I/I mis1 syn10--------
    --
    rs25278821,2
    C99401897(-) CTCTCC/TCAATA 1 -- ng510--------
    --
    rs18942351,2
    H99407498(-) TTTCAG/AGCCCT 1 Q/Q syn1 ese35Minor allele frequency- A:0.00MN EU EA WA 604
    --
    rs25255541,2
    A,C,F,H99404343(+) atggcA/Gaaatc 1 -- int17Minor allele frequency- G:0.50EU EA WA NA 554
    --
    rs25279171,2
    A,C,F,H99405844(-) gcctgG/Agtgac 1 -- int18Minor allele frequency- A:0.25EU EA WA 838
    --
    rs19875801,2
    A,C,H99408522(-) attttG/Ttgaat 1 -- int14Minor allele frequency- T:0.00EU EA WA 418
    rs25279231,2
    C,F,H99405391(-) AGAAAG/AGTAGA 1 -- int13Minor allele frequency- A:0.37EU EA 278
    About this table

    HapMap Linkage Disequilibrium images for AZGP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 194460

    9 Novoseek disease relationships for AZGP1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cysts 63.96 4 9114041 (2), 1828959 (1)
    breast diseases 56.37 2 9114041 (1)
    breast carcinoma 46.46 6 1444749 (2), 8049458 (1), 9114041 (1), 8307568 (1)
    breast cancer 13.36 2 2202419 (1)
    cancer 8.25 8 12190871 (2), 16475792 (1), 15620688 (1), 15449322 (1) (see all 6)
    prostate cancer 3.54 10 11309332 (4), 16598739 (2), 17317883 (2)
    melanoma 0.00 2 12190871 (1)
    tumors 0.00 13 11309332 (3), 12190871 (2), 2244662 (1), 16598739 (1) (see all 7)
    metastasis 0.00 2 1444749 (1), 16598739 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/80 PubMed articles for AZGP1 gene (see all 80 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 563 HGNC: 910 AceView: AZGP1 Ensembl:ENSG00000160862 euGenes: HUgn563
    ECgene: AZGP1 H-InvDB: AZGP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for AZGP1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AZGP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for AZGP1 Antibodies for AZGP1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for AZGP1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for AZGP1

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