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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AZF1 Locus

genetic locus   GIFtS: 15
GCID: GC0YU990003

Azoospermia Factor 1


(Previous symbol: AZF)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Azoospermia Factor 11 2
AZF1 2
AZFA2
SP32

External Ids:    HGNC: 9081   Entrez Gene: 5602   OMIM: 4150005   

Export aliases for AZF1 gene to outside databases

Previous GC identifer: GC00U922184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AZF1 Gene: 
AZF1 (azoospermia factor 1) is a genetic locus. Diseases associated with AZF1 include varicocele, and partial deletion of y.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AZF1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAZF1 promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZF1


Genomic Location:
Chromosome:Y   

Entrez Gene cytogenetic band: Yq11   HGNC cytogenetic band: Yq11

GeneLoc information about chromosome Y        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for AZF1 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AZF1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
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AZF1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AZF1

1 Novoseek inferred chemical compound relationship for AZF1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
azfd 90.2 3 10230814 (2), 19421675 (1)

Search CenterWatch for drugs/clinical trials and news about AZF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidAZF1 3' UTR sequence
Inhib. RNA
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

    SABiosciences Custom PCR Arrays for AZF1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZF1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Human Gene Mutation Database (HGMD): AZF1
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing AZF1
DNA2.0 Custom Variant and Variant Library Synthesis for AZF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 415000    OMIM disorders: --

15 diseases for AZF1:    About MalaCards
varicocele    partial deletion of y    klinefelter's syndrome    oligospermia
mixed gonadal dysgenesis    cryptorchidism    testicular cancer    sertoli cell-only syndrome
azoospermia    male infertility    gonadal dysgenesis    lymphedema
prader-willi syndrome    infertility    germ cell tumors


AZF1 for disorders           About GeneDecksing

10/15 Novoseek inferred disease relationships for AZF1 gene (see all 15)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
azoospermia 96.4 162 18393244 (3), 8042776 (2), 8711205 (2), 12150339 (2) (see all 99)
oligozoospermia 93.5 22 8622504 (2), 17478930 (2), 16466551 (1), 17050323 (1) (see all 18)
infertility male 90.8 29 11139528 (2), 20369704 (2), 10767340 (1), 15845593 (1) (see all 24)
chromosome deletion 86.5 3 9813189 (1), 12826698 (1), 16862061 (1)
infertility 78.4 18 9447460 (2), 18357961 (2), 12900510 (2), 16157049 (2) (see all 14)
klinefelters syndrome 74.3 8 19909597 (2), 20369704 (1), 17968468 (1), 19072570 (1)
cryptorchidism 57.4 7 11869370 (2), 12508125 (2), 15066457 (2), 20369704 (1)
varicocele 49.1 3 12508125 (2), 20369704 (1)
chromosomal aberrations 44.5 9 16612480 (2), 18393244 (2), 17683468 (1), 19072570 (1)
virilization 39.6 1 15136108 (1)

Genetic Association Database (GAD): AZF1
Human Genome Epidemiology (HuGE) Navigator: AZF1 (1 document)

Export disorders for AZF1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for AZF1 gene, integrated from 9 sources (see all 182):
(articles sorted by number of sources associating them with AZF1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular analysis of defects in the CFTR gene and AZF locus of the Y chromosome in male infertility. (PubMed id 16572913)1, 4, 9 Sobczynska-Tomaszewska A....Bal J. (2006)
  2. High prevalence of AZFb microdeletion in Iranian pati ents with idiopathic non-obstructive azoospermia. (PubMed id 20847372)1, 4 Mirfakhraie R....Houshmand M. (2010)
  3. Spermatogenesis in a man with complete deletion of US P9Y. (PubMed id 19246359)1, 3 Luddi A....Piomboni P. (2009)
  4. Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility. (PubMed id 17412880)1, 4 Zhang F....Jin L. (2007)
  5. A frequent partial AZFc deletion does not render an increased risk of spermatogenic impairment in East Asians. (PubMed id 16674553)1, 4 Zhang F....Jin L. (2006)
  6. Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility. (PubMed id 10767340)1, 9 Foresta C....Moro E. (2000)
  7. No AZF deletion in 160 patients with testicular germ cell neoplasia. (PubMed id 12900510)1, 9 Frydelund-Larsen L....Rajpert-De Meyts E. (2003)
  8. SRY and AZF gene variation in male infertility: a cytogenetic and molecular approach. (PubMed id 17762975)1, 9 Ozdemir O....Sezgin I. (2007)
  9. Natural transmission of USP9Y gene mutations: a new perspective on the role of AZFa genes in male fertility. (PubMed id 16893908)1, 9 Krausz C....Forti G. (2006)
  10. Routine screening for classical azoospermia factor deletions of the Y chromosome in azoospermic patients with Klinefelter syndrome. (PubMed id 17968468)1, 9 Choe J.H....Seo J.T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 560 HGNC: 908 euGenes: HUgn560 ECgene: AZF1 H-InvDB: AZF1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for AZF1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for AZF1 gene:
Search GeneIP for patents involving AZF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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