AZF1 Locus
genetic locus GIFtS: 16
GCID: GC0YU990003
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azoospermia factor 1
(Previous symbol: AZF)
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Aliases
for AZF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Azoospermia Factor 11 2 | | AZF1 2 | | AZFa1 | | AZFA2 | | SP32 |
Export aliases for AZF1 gene to outside databasesPrevious GC identifer: GC00U922184 |
Summaries
for AZF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for AZF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AZF1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AZF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZF1 |
Genomic Location:
Chromosome:Y
Entrez Gene cytogenetic band: Yq11 HGNC cytogenetic band: Yq11GeneLoc information about chromosome Y |
Proteins
for AZF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for AZF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for AZF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZF1 |
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Pathways & Interactions
for AZF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AZF1
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Drugs & Compounds
for AZF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AZF1 for compounds About GeneDecksing
 Browse Tocris compounds for AZF1
1 Novoseek chemical compound relationship for AZF1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| azfd |
90.2 |
3 |
10230814 (2), 19421675 (1) |
Search CenterWatch for drugs/clinical trials and news about AZF1 
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Transcripts
for AZF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for AZF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for AZF1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AZF1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZF1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZF1 |
Orthologs
for AZF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for AZF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for AZF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Human Gene Mutation Database (HGMD): AZF1
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for AZF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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AZF1 for disorders About GeneDecksing
OMIM gene information: 415000
OMIM disorders: --
20/21  diseases for AZF1 (see all 21): About MalaCardsazoospermia sertoli cell-only syndrome mixed gonadal dysgenesis gonadal dysgenesis
partial deletion of y prader-willi syndrome testicular germ cell tumor germ cell tumor
cryptorchidism klinefelter's syndrome spontaneous abortion cryptorchidism, idiopathic
virilization varicocele male infertility oligospermia
testicular cancer infertility lymphedema twinning
10/15 Novoseek disease relationships for AZF1 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| azoospermia |
96.4 |
162 |
18393244 (3), 8042776 (2), 8711205 (2), 12150339 (2) (see all 99) |
| oligozoospermia |
93.5 |
22 |
8622504 (2), 17478930 (2), 16466551 (1), 17050323 (1) (see all 18) |
| infertility male |
90.8 |
29 |
11139528 (2), 20369704 (2), 10767340 (1), 15845593 (1) (see all 24) |
| chromosome deletion |
86.5 |
3 |
9813189 (1), 12826698 (1), 16862061 (1) |
| infertility |
78.4 |
18 |
9447460 (2), 18357961 (2), 12900510 (2), 16157049 (2) (see all 14) |
| klinefelters syndrome |
74.3 |
8 |
19909597 (2), 20369704 (1), 17968468 (1), 19072570 (1) |
| cryptorchidism |
57.4 |
7 |
11869370 (2), 12508125 (2), 15066457 (2), 20369704 (1) |
| varicocele |
49.1 |
3 |
12508125 (2), 20369704 (1) |
| chromosomal aberrations |
44.5 |
9 |
16612480 (2), 18393244 (2), 17683468 (1), 19072570 (1) |
| virilization |
39.6 |
1 |
15136108 (1) |
Human Genome Epidemiology (HuGE) Navigator: AZF1 (1 document)
Export disorders for AZF1 gene to outside databases
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Publications
for AZF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for AZF1 gene, integrated from 9 sources (see all 182):
(articles sorted by number of sources associating them with AZF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Spermatogenesis in a man with complete deletion of US P9Y. (PubMed id 19246359)1, 3 Luddi A....Piomboni P. (2009)
- Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility. (PubMed id 10767340)1, 9 Foresta C....Moro E. (2000)
- No AZF deletion in 160 patients with testicular germ cell neoplasia. (PubMed id 12900510)1, 9 Frydelund-Larsen L....Rajpert-De Meyts E. (2003)
- SRY and AZF gene variation in male infertility: a cytogenetic and molecular approach. (PubMed id 17762975)1, 9 Ozdemir O....Sezgin I. (2007)
- Natural transmission of USP9Y gene mutations: a new perspective on the role of AZFa genes in male fertility. (PubMed id 16893908)1, 9 Krausz C....Forti G. (2006)
- Routine screening for classical azoospermia factor deletions of the Y chromosome in azoospermic patients with Klinefelter syndrome. (PubMed id 17968468)1, 9 Choe J.H....Seo J.T. (2007)
- Molecular analysis of defects in the CFTR gene and AZF locus of the Y chromosome in male infertility. (PubMed id 16572913)1, 9 Sobczynska-Tomaszewska A....Bal J. (2006)
- Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions. (PubMed id 12871878)1, 9 Hopps C.V....Schlegel P.N. (2003)
- AZF microdeletions associated with idiopathic and non-idiopathic cases with cryptorchidism and varicocele. (PubMed id 12508125)1, 9 Dada R....Kucheria K. (2002)
- Genetic association between AZF region polymorphism a nd Klinefelter syndrome. (PubMed id 19909597)1, 9 Hadjkacem-Loukil L....Ammar-Keskes L. (2009)
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External Searches for AZF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing AZF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing AZF1 gene
(According to HUGE)
About This Section
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Specialized Databases showing AZF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for AZF1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for AZF1 gene:
Search GeneIP for patents involving AZF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AZF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AZF1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AZF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AZF1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AZF1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AZF1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AZF1 |
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| | | | Search Tocris compounds for AZF1 |
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 | | | AZF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AZF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AZF1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AZF1 |
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