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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AXL Gene

protein-coding   GIFtS: 71
GCID: GC19P041725

AXL Receptor Tyrosine Kinase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AXL Receptor Tyrosine Kinase1 2     JTK112
UFO2 3     AXL Transforming Sequence/Gene2
AXL Oncogene2 3     Tyrosine-Protein Kinase Receptor UFO2
EC 2.7.10.13 8     EC 2.7.108

External Ids:    HGNC: 9051   Entrez Gene: 5582   Ensembl: ENSG000001676017   OMIM: 1091355   UniProtKB: P305303   

Export aliases for AXL gene to outside databases

Previous GC identifers: GC19P042364 GC19P042116 GC19P046400 GC19P046416 GC19P038157


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AXL Gene:
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The
encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the
N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into
the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be
involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple
cell types. Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq, Jul
2013)

GeneCards Summary for AXL Gene: 
AXL (AXL receptor tyrosine kinase) is a protein-coding gene. Diseases associated with AXL include femoral neuropathy, and critical limb ischemia, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include phosphatidylserine binding and protein heterodimerization activity. An important paralog of this gene is MET.

UniProtKB/Swiss-Prot: UFO_HUMAN, P30530
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival,
cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and
autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of
PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate
candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase
regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role
in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal
cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing
hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an
important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus
infection, seems to function as a cell entry factor

Gene Wiki entry for AXL (AXL receptor tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AXL gene promoter:
         AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAXL promoter sequence
   Search SABiosciences Chromatin IP Primers for AXL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AXL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

AXL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AXL gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041725:  view genomic region     (about GC identifiers)

Start:
41,725,108 bp from pter      End:
41,767,671 bp from pter
Size:
42,564 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UFO_HUMAN, P30530 (See protein sequence)
Recommended Name: Tyrosine-protein kinase receptor UFO precursor  
Size: 894 amino acids; 98336 Da
Subunit: Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2,
PIK3R3, PLCG1, SOCS1 and TENC1. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL
recruitment by TNK2
Subcellular location: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for AXL:
2C5D (3D)    
Secondary accessions: Q8N5L2 Q9UD27
Alternative splicing: 2 isoforms:  P30530-1   P30530-2   

Explore the universe of human proteins at neXtProt for AXL: NX_P30530

Explore proteomics data for AXL at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to
    polyubiquitination in a very transient fashion
  • UniProtKB: Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30530

  • 4/9 DME Specific Peptides for AXL (P30530) (see all 9)
     GNRLKQP  RDLAARN  GDYYRQG  FSCEAHN 

    AXL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AXL Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265528.1  NP_001690.2  NP_068713.2  

    ENSEMBL proteins: 
     ENSP00000301178   ENSP00000351995   ENSP00000471497  

    Human Recombinant Protein Products for AXL: 
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    Novus Biologicals AXL Proteins
    Novus Biologicals AXL Lysates
    Sino Biological Recombinant Protein for AXL
    Sino Biological Cell Lysate for AXL 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AXL 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005887integral to plasma membrane TAS1656220
    GO:0009986cell surface IDA19657094
    GO:0016021integral to membrane ----

    AXL for ontologies           About GeneDecksing



    AXL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AXL
    R&D Systems Antibodies for AXL
    Cell Signaling Technology (CST) Antibodies for AXL 
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    Novus Biologicals AXL Antibodies
    Abcam antibodies for AXL
    Cloud-Clone Corp. Antibodies for AXL 
    ThermoFisher Antibody for AXL
    LSBio Antibodies in human, mouse, rat for AXL 

    Assay Products for AXL: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for AXL         (see all)
    GenScript Custom Assay Services for AXL
    Cell Signaling Technology (CST) Sandwich ELISA Kits for AXL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AXL 
    Cloud-Clone Corp. CLIAs for AXL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: AXL receptor tyrosine kinase 
    TAM (or AXL) receptor family
    Axl family

    5/11 InterPro protein domains (see all 11):
     IPR007110 Ig-like_dom
     IPR017441 Protein_kinase_ATP_BS
     IPR003599 Ig_sub
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry P30530

    ProtoNet protein and cluster: P30530

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: UFO_HUMAN, P30530
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    AXL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UFO_HUMAN, P30530
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival,
    cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and
    autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of
    PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate
    candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase
    regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role
    in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal
    cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing
    hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an
    important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus
    infection, seems to function as a cell entry factor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by GAS6-binding and subsequent autophosphorylation

         Genatlas biochemistry entry for AXL:
    AXL transforming sequence,activated by GAS6,involved in the protection of neurons from apoptosis across neuronal
    migration,expressed in neural lymphoid,vascular and reproductive tissue,involved in the regulation of
    spermatogenesis and in primary and tumor cell lines derived from these sources

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI16362042
         
    AXL for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for AXL:
     Decreased substrate adherent c  Increased cell death in breast  Increased mitotic index  Increased viability after born 

         14 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Axl):
     cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 
     normal  reproductive system  skeleton  vision/eye 

    AXL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Axltm1Grl for AXL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AXL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AXL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AXL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AXL 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AXL:
    hsa-mir-1 (MIRT002758)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AXL
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate AXL (see all 22):
    hsa-miR-25 hsa-miR-650 hsa-miR-449a hsa-miR-24 hsa-miR-33b hsa-miR-3612 hsa-miR-92b hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidAXL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AXL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AXL

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AXL (NM_021913)
    Sino Biological Human cDNA Clone for AXL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AXL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXL
    Sirion Biotech Customized lentivirus for stable overexpression of AXL 
                         Customized lentivirus expression plasmids for stable overexpression of AXL 

    Cell Line
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    Search LifeMap BioReagents cell lines for AXL
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AXL About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AXL (see all 29)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for AXL
        Tyrosine Kinases / Adaptors




    AXL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AXL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for AXL (P305302, 3 ENSP000003011784) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAS6Q143932, 3, ENSP000003318314MINT-2735822 MINT-2735908 MINT-2738515 MINT-2735786 MINT-2735853 MINT-2735881 MINT-2735935 MINT-2735964 I2D: score=5 STRING: ENSP00000331831
    PIK3R1P279862, 3, ENSP000002743354MINT-8028639 MINT-8028655 I2D: score=5 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8028607 MINT-8028623 I2D: score=4 STRING: ENSP00000244007
    GRB2P629932, 3, ENSP000003390074MINT-8026688 MINT-8028671 MINT-8028687 I2D: score=4 STRING: ENSP00000339007
    LCKP062393, ENSP000003378254I2D: score=4 STRING: ENSP00000337825
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0001779natural killer cell differentiation IEA--
    GO:0001961positive regulation of cytokine-mediated signaling pathway IDA18840707
    GO:0001974blood vessel remodeling IEA--
    GO:0006468protein phosphorylation ----

    AXL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AXL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for AXL

    Browse Tocris compounds for AXL (UFO)

    2 HMDB Compounds for AXL    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 IUPHAR Ligands for AXL (AXL receptor tyrosine kinase)    About this table 
    LigandTypeActionAffinityPubmed IDs
    protein S
    NoneNone7867073
    growth arrest specific protein 6
    NoneNone8939948

    7 Novoseek inferred chemical compound relationships for AXL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 80.5 193 1656220 (5), 15964779 (4), 9259426 (4), 9287338 (3) (see all 99)
    gamma-carboxyglutamic acid 62.4 8 18760998 (2), 12871548 (1), 15605394 (1)
    wortmannin 51.2 1 17255529 (1)
    warfarin 44.4 4 11290560 (1), 15199298 (1), 11546821 (1)
    ly294002 41.7 2 15380678 (1), 19027714 (1)
    phosphatidylinositol 39.2 2 17255529 (1), 15380678 (1)
    phosphatidylserine 18.2 3 18760998 (2)

    Search CenterWatch for drugs/clinical trials and news about AXL / UFO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AXL gene (3 alternative transcripts): 
    NM_001278599.1  NM_001699.5  NM_021913.4  

    Unigene Cluster for AXL:

    AXL receptor tyrosine kinase
    Hs.590970  [show with all ESTs]
    Unigene Representative Sequence: NM_021913
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301178(uc010ehi.1 uc010ehj.3) ENST00000359092(uc010ehk.3)
    ENST00000599659 ENST00000594880 ENST00000593513
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate AXL (see all 22):
    hsa-miR-25 hsa-miR-650 hsa-miR-449a hsa-miR-24 hsa-miR-33b hsa-miR-3612 hsa-miR-92b hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidAXL 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AXL
    Clone
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    OriGene ORF clones in mouse, rat for AXL
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    GenScript: all cDNA clones in your preferred vector (see all 2): AXL (NM_021913)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AXL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXL
    Sirion Biotech Customized lentivirus for stable overexpression of AXL 
                         Customized lentivirus expression plasmids for stable overexpression of AXL 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AXL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AXL

    Additional mRNA sequence: 

    AK309139.1 AK310881.1 BC032229.1 M76125.1 S65125.1 X57019.1 X66029.1 

    15 DOTS entries:

    DT.100786483  DT.97805775  DT.91755245  DT.100029048  DT.100041719  DT.100780536  DT.456157  DT.121460717 
    DT.121460881  DT.121461087  DT.91677197  DT.91681161  DT.95191274  DT.95375668  DT.91683879 

    24/304 AceView cDNA sequences (see all 304):

    F08146 AI418665 AI309979 AI160138 BG251255 BQ641894 BQ929060 BU542214 
    BM669998 BQ446686 BM719192 BE909134 CB160525 BM449982 AW008618 CA418366 
    W76451 AI371020 AI299882 BQ435953 BM915347 BI871630 BM695457 BQ774129 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AXL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:              -                                                                                                                           
    SP2:              -                                                           -                                                               
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for AXL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AXL expression in normal human tissues (normalized intensities)      AXL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCCCCCGT
    AXL Expression
    About this image


    AXL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Myocytes   
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Smooth Muscle (Muscoskeletal System)
     
     Bone (Muscoskeletal System)

    See AXL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AXL

    SOURCE GeneReport for Unigene cluster: Hs.590970

    UniProtKB/Swiss-Prot: UFO_HUMAN, P30530
    Tissue specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly
    expressed in normal colon tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AXL gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Axl1 , 5 AXL receptor tyrosine kinase1, 5 85.57(n)1
    88.61(a)1
      7 (14.02 cM)5
    263621  NM_001190974.11  NP_001177903.11 
     257572735 
    lizard
    (Anolis carolinensis)
    Reptilia AXL6
    AXL receptor tyrosine kinase
    60(a)
    1 ↔ 1
    LGf(3521319-3616786)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01088927.16
    CABZ01088930.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    56(a)
    56(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    15(27341-34669)
    15(20172-27007)


    ENSEMBL Gene Tree for AXL (if available)
    TreeFam Gene Tree for AXL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AXL gene
    MET2  RYK2  TYRO32  MERTK2  MST1R2  
    18/32 SIMAP similar genes for AXL using alignment to 2 protein entries:     UFO_HUMAN (see all proteins) (see all similar genes):
    ufo    FLT4    EPHA4    ABL1    TYRO3    EPHA2
    FLT1    MST1R    MERTK    BRAF    DKFZp434L0319    BTK kinase deficient isoform 6
    FES    MET    RYK    PTK7    TXK    STK25

    AXL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1126 SNPs in AXL are shown (see all 1126)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0455974
    A lung neuroendocrine carcinoma sample4--see VAR_0455972 R W mis40--------
    VAR_0418774
    A gastric adenocarcinoma sample4--see VAR_0418772 R C mis40--------
    VAR_0418784
    ----see VAR_0418782 S G mis40--------
    VAR_0579904
    ----see VAR_0579902 N D mis40--------
    rs1427061271,2
    C--41723175(+) GGGGC-/AGAGGT 2 -- us2k10--------
    rs1467017151,2
    --41723274(+) ATGGCC/TGGGCA 2 -- us2k10--------
    rs1400585351,2
    C--41723335(+) ATCACA/GAGTTC 2 -- us2k10--------
    rs1814930321,2
    --41723426(+) CACACC/TTGTAA 2 -- us2k10--------
    rs104246461,2
    C,F,A--41723512(+) agccaC/Ttgcac 2 -- us2k12Minor allele frequency- T:0.33WA CSA 3
    rs575523731,2
    C--41723571(+) AAAAA-/A/GGACAC 2 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for AXL (41725108 - 41767671 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AXL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911768CNV Loss21882294
    nsv819422CNV Loss19587683
    esv995062CNV Loss20482838


    Human Gene Mutation Database (HGMD): AXL
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for AXL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109135    OMIM disorders: --

    UniProtKB/Swiss-Prot: UFO_HUMAN, P30530
  • Note=AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be
    involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers
    such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer

  • 20/59 diseases for AXL (see all 59):    About MalaCards
    femoral neuropathy    critical limb ischemia    ocular melanoma    ovarian endometriosis
    amblyopia    refractive error    glomerulonephritis    abdominal aortic aneurysm
    endometriosis    pancreatic ductal adenocarcinoma    aortic aneurysm    myeloid leukemia
    myopia    b-cell chronic lymphocytic leukemia    leiomyoma    noma
    thrombosis    esophageal adenocarcinoma    kaposi's sarcoma    thyroid cancer

    2 diseases from the University of Copenhagen DISEASES database for AXL:
    Cancer     Refractive error

    AXL for disorders           About GeneDecksing

    10/29 Novoseek inferred disease relationships for AXL gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 49.9 7 8656672 (1), 9130617 (1), 1656220 (1), 15380678 (1) (see all 6)
    glomerulonephritis mesangial proliferative 45.7 1 11290560 (1)
    myeloid leukemia chronic 34.6 8 7521695 (2), 8235704 (1), 7848912 (1), 20145042 (1) (see all 5)
    thyroid carcinoma 25 17 10411118 (6), 9492013 (3), 12490074 (3)
    renal disease 24.1 3 14750094 (2), 12768229 (1)
    myeloproliferative disorders 17.9 3 7521695 (1)
    carcinoma papillary 17.1 1 12490074 (1)
    inflammation 16.6 3 9516131 (1), 16831897 (1), 15964779 (1), 17708828 (1)
    diabetic nephropathies 16.1 2 18374201 (1)
    metastasis 15.9 23 20145120 (2), 19633687 (2), 20080645 (2), 10411118 (2) (see all 10)

    Genetic Association Database (GAD): AXL
    Human Genome Epidemiology (HuGE) Navigator: AXL (6 documents)

    Export disorders for AXL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AXL gene, integrated from 9 sources (see all 218):
    (articles sorted by number of sources associating them with AXL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. (PubMed id 1656220)1, 2, 3, 9 O'Bryan J.P.... Liu E.T. (1991)
    2. Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. (PubMed id 15958209)1, 2, 9 Valverde P. (2005)
    3. Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl. (PubMed id 12490074)1, 2, 9 Ito M....Yamashita S. (2002)
    4. Cytoplasmic ACK1 interaction with multiple receptor t yrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signali ng. (PubMed id 19815557)1, 2, 9 Pao-Chun L....Manser E. (2009)
    5. Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. (PubMed id 15507525)1, 2, 9 Gallicchio M....Bussolino F. (2005)
    6. Acidification prevents endothelial cell apoptosis by Axl activation. (PubMed id 12364394)1, 2, 9 D'Arcangelo D....Capogrossi M.C. (2002)
    7. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. (PubMed id 7854420)1, 2, 9 Varnum B.C.... Yamane H.K. (1995)
    8. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2, 9 Hafizi S.... Dahlbaeck B. (2002)
    9. Structural basis for Gas6-Axl signalling. (PubMed id 16362042)1, 2, 9 Sasaki T.... Hohenester E. (2006)
    10. A novel putative tyrosine kinase receptor with oncogenic potential. (PubMed id 1834974)1, 2, 9 Janssen J.W.G.... Bartram C.R. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 558 HGNC: 905 AceView: AXL Ensembl:ENSG00000167601 euGenes: HUgn558
    ECgene: AXL H-InvDB: AXL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AXL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AXL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AXL gene:
    Search GeneIP for patents involving AXL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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