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AXL Gene

protein-coding GIFtS: 68

GC19P046416

AXL receptor tyrosine kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.1 ^³
JTK11 ^¹, ²
UFO ^¹, ², ³

Descriptions
AXL oncogene ^³
AXL receptor tyrosine kinase ^²
AXL transforming sequence/gene ^²
oncogene AXL ^²

External Ids
HGNC: 905¹
Entrez Gene: 558²
UniProtKB: P30530³
Ensembl: ENSG00000167601⁷

Search outside databases for aliases for AXL gene

Previous GC identifers: GC19P042364 GC19P042116 GC19P046400

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AXL:

The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it

is similar to other receptor tyrosine kinases, this protein represents a unique structure of the

extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the

extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein

growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can

also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants

encoding different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: UFO_HUMAN, P30530

Function: May function as a signal transducer between specific cell types of mesodermal origin. In

case of filovirus infection, seems to function as a cell entry factor

Gene Wiki entry for AXL (AXL_receptor_tyrosine_kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AXL gene

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1

AXL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046416: (about GC identifiers)

Start:	46,416,948 bp from pter
End:	46,459,511 bp from pter
Size:	42,564 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UFO_HUMAN, P30530 (See protein sequence)

Recommended Name: Tyrosine-protein kinase receptor UFO precursor

Size: 894 amino acids; 98336 Da

Subunit: Heterodimer and heterotetramer with GAS6

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

2C5D (3D)

Secondary accessions: Q8N5L2 Q9UD27

Alternative splicing: 2 isoforms: P30530-1 P30530-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001690.2 NP_068713.2

ENSEMBL proteins:

ENSP00000351995 ENSP00000301178

Human Recombinant Proteins

	Invitrogen human recombinant proteins for AXL
	Millipore Purified and/or Recombinant AXL Protein
	Sigma-Aldrich Proteins for AXL
	R&D Systems Recombinant & Natural Proteins for AXL
	Enzo Life Sciences proteins for AXL
	Recombinant Proteins from Abcam (Axl)
	Human Recombinant Proteins from Abnova (AXL)

OriGene Purified Recombinant Human Protein: AXL

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	1656220
GO:0016020	membrane	IEA	--

About this table

Antibodies for AXL:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AXL
	R&D Systems Antibodies for AXL
	Cell Signaling Technology (CST) Antibodies for AXL
	Antibodies from Abcam (Axl), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AXL)
	Novus Biologicals Antibodies for AXL

Assays for AXL:

	Invitrogen Assays for AXL
	Millipore Kits and Assays for the Analysis of AXL
	R&D Systems ELISAs for AXL (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P30530

ProtoNet protein and cluster: P30530

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: UFO_HUMAN, P30530

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily

Similarity: Contains 2 fibronectin type-III domains

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AXL)
		Millipore RNAi Products for the Analysis of AXL Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (AXL)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001699

Applied Biosystems Silencer® siRNAs for AXL

Sigma-Aldrich siRNA and siRNA Panels for AXL

Sigma-Aldrich shRNA Panels and shRNA for AXL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AXL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001699
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001699
untagged cDNA clones in CMV expression vector (see all 3): NM_001699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021913

UniProtKB/Swiss-Prot: UFO_HUMAN, P30530

Function: May function as a signal transducer between specific cell types of mesodermal origin. In

case of filovirus infection, seems to function as a cell entry factor

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for AXL:

AXL transforming sequence,activated by GAS6,involved in the protection of neurons from apoptosis

across neuronal migration,expressed in neural lymphoid,vascular and reproductive tissue,involved

in the regulation of spermatogenesis and in primary and tumor cell lines derived from these

sources

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Axl):

	cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	nervous system	normal	reproductive system
skeleton	skin/coat/nails	vision/eye

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	TAS	1656220
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for AXL (Your Favorite Gene powered by Ingenuity)

IL-15 Signaling

GeneDecks AXL for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AXL

5/23 Interacting proteins for AXL (P30530² ENSP00000301178³) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GAS6	Q14393², ENSP00000349962³	MINT-2735822 MINT-2735908 MINT-2738515 MINT-2735786 MINT-2735853 MINT-2735881 MINT-2735935 MINT-2735964 STRING (score=.999)
PROS1	ENSP00000330021³	STRING (score=.992)
GRB2	ENSP00000339007³	STRING (score=.965)
PIK3R2	ENSP00000222254³	STRING (score=.957)
RANBP9	ENSP00000011619³	STRING (score=.956)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	1656220

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AXL
4 Novoseek chemical compound relationships for AXL gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	79.94	168	1656220 (5), 15964779 (4), 9259426 (4), 9287338 (3) (see all 99)
gamma-carboxyglutamic acid	63.71	8	18760998 (2), 12871548 (1), 15605394 (1)
wortmannin	53.11	1	17255529 (1)
phosphatidylinositol	41.36	2	17255529 (1), 15380678 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AXL)
		Millipore RNAi Products for the Analysis of AXL Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (AXL)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001699

Sigma-Aldrich siRNA and siRNA Panels for AXL

Sigma-Aldrich shRNA Panels and shRNA for AXL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001699 NM_021913

REFSEQ mRNAs for AXL gene (2 alternative transcripts):

NM_001699.4 NM_021913.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001699 NM_021913

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001699
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001699
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001699

Additional cDNA sequence:

AK309139.1 AK310881.1 BC032229.1 M76125.1 S65125.1 X57019.1 X66029.1

15 DOTS entries:

DT.100786483 DT.97805775 DT.91755245 DT.100029048 DT.100780536 DT.456157 DT.100041719 DT.121460717

DT.91677197 DT.91683879 DT.121460881 DT.121461087 DT.91681161 DT.95191274 DT.95375668

24/304 AceView cDNA sequences (see all 304 ):

BI871630 BU542214 CB160525 BQ960243 AA330590 AW838036 BQ435953 AA425944

AI309979 BM449982 BM695457 AI343551 BQ446686 AW838042 F07212 BQ774129

CN482730 AW377752 CA440405 CA418366 BQ641894 CD671303 BQ708279 AI096939

highest scoring ESTs for AXL:

M76125 AA039995 AA040011 AA302422 AA641133 AI073459 AI160010 AI350512 AI393212 AI420198

Unigene Cluster for AXL:

AXL receptor tyrosine kinase

Hs.590970 [show with all ESTs]

Unigene Representative Sequence: NM_021913

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for AXL

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:					-
SP2:					-																				-
SP3:

About this scheme

ECgene alternative splicing isoforms for AXL

2 Ensembl transcripts including schematic representations:

ENST00000359092 ENST00000301178

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AXL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AXL

¹ / ² / ³

7 probe-sets matching AXL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1278_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.03	HG162-HT3165	0.20	1.00	0.72	1
1233_s_at²^{, 3}	U95-A	1	1.00	1.00	0.35	0.89	M76125	1.00	1.00	1.00	1
38433_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.10	M76125	1.00	1.00	1.00	1
202685_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI467916	0.80	1.00	0.91	1
202686_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021913	0.40	1.00	0.76	1
202685_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202686_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AXL for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGCCCCCGT

SOURCE GeneReport for Unigene cluster: Hs.590970
Expression variation in blood from EXPOLDB for AXL
UniProtKB/Swiss-Prot: UFO_HUMAN, P30530
Tissue specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors.
Weakly expressed in normal colon tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AXL gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AXL¹	--	AXL receptor tyrosine kinase	88.23(n) 90.55(a)	484490 XM_541604.2 XP_541604.2
cow (Bos taurus)	AXL¹	--	AXL receptor tyrosine kinase	82.38(n) 84.21(a)	516598 XM_594754.3 XP_594754.3
rat (Rattus norvegicus)	Axl¹	--	Axl receptor tyrosine kinase	85.31(n) 88.61(a)	308444 NM_001013147.1 NP_001013165.1
mouse (Mus musculus)	Axl^{1, 5}	7 (6.00 cM)⁵	AXL receptor tyrosine kinase^{1, 5}	85.57(n)¹ 88.61(a)¹	26362¹ NM_009465.3¹ NP_033491.2¹ AA500897⁵ AI323647⁵ (see all 20)
worm (Caenorhabditis elegans)	T14E8.1b³	X(6588581-6594203)	--	34(a) (best of 3)	--

About this table Species with no ortholog for AXL

ENSEMBL Gene Tree for AXL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AXL gene

RYK² TYRO3² MERTK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/254 NCBI SNPs in AXL are shown (see all 254 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 72)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8101017^1,2	A,C,F,H	46415727(+)	`TAGACG/TCCCAG`	2	--	ng5¹		7		EU EA NA	662
	rs2301236^1,2	C,F,H	46416660(+)	`TGAGAG/AGGGAG`	2	--	ng5¹ trp³		7		EA MN EU WA	2946
--	rs8101568^1,2	A,C	46416330(+)	`GTCCCC/GCATGG`	2	--	ng5¹		0	--	--	--	--
	rs7249222^1,2	C,H	46435701(+)	`TGTCAG/AACGAT`	2	N/D	mis¹		4		EU EA WA	416
	rs35202236^1,2	C,F	46418917(+)	`CGACAC/TGGGAC`	2	T/M	mis¹		4		EU EA WA	416
	rs28364580^1,2	F	46416725(+)	`AGCCCG/AGATAG`	2	--	ng5¹ ese³		2		MN EA	1252
--	rs10411012^1,2	C	46417111(+)	`GCCCAA/GCAACT`	2	--	ut5¹		0	--	--	--	--
	rs1004955^1,2	H	46457353(-)	`CTCTGT/CAAAAC`	2	A/T	mis¹ ese³		5		MN EU EA WA	604
	rs35538872^1,2	C	46446270(+)	`GCCTGG/AGCATC`	2	S/G	mis¹		4		EU EA WA	420
--	rs17856940^1,2	H	46455332(+)	`GCGCCA/GGGGAA`	2	Q/R	mis¹ ese³		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for AXL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109135

UniProtKB/Swiss-Prot: UFO_HUMAN, P30530

Has transforming potential in patients with chronic myeloproliferative disorder or chronic

myelocytic leukemia

10/29 Novoseek disease relationships for AXL gene (see all 29 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	51.75	7	8656672 (1), 9130617 (1), 1656220 (1), 15380678 (1) (see all 6)
glomerulonephritis mesangial proliferative	47.47	1	11290560 (1)
myeloid leukemia chronic	31.65	7	7521695 (2), 8235704 (1), 7848912 (1), 10528229 (1)
thyroid carcinoma	27.54	17	10411118 (6), 9492013 (3), 12490074 (3)
renal disease	27.40	3	14750094 (2), 12768229 (1)
myeloproliferative disorders	20.37	3	7521695 (1)
carcinoma papillary	19.47	1	12490074 (1)
diabetic nephropathies	18.83	2	18374201 (1)
glomerulonephritis	17.60	4	11290560 (1), 12644472 (1), 15199298 (1)
leukemia	15.23	12	10482985 (3), 8656672 (2), 10528229 (1), 15605394 (1) (see all 6)

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Human Gene Mutation Database: AXL

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/147 PubMed articles for AXL gene (see all 147 ):

AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. (PubMed id 1656220)^{1, 2, 3, 4} O'Bryan J.P.... Liu E.T. (1991)
Structural basis for Gas6-Axl signalling. (PubMed id 16362042)^{1, 3, 4} Sasaki T.... Hohenester E. (2006)
A novel putative tyrosine kinase receptor with oncogenic potential. (PubMed id 1834974)^{1, 3, 4} Janssen J.W.G.... Bartram C.R. (1991)
Tyro3 family-mediated cell entry of Ebola and Marburg viruses. (PubMed id 17005688)^{3, 4} Shimojima M....Kawaoka Y. (2006)
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. (PubMed id 8247543)^{3, 4} Lee S.-T.... Spritz R.A. (1993)
Putative tyrosine kinases expressed in K-562 human leukemia cells. (PubMed id 2247464)^{3, 4} Partanen J.... Alitalo K. (1990)
The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. (PubMed id 15964779)^{1, 3} Hafizi S....Dahlback B. (2005)
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme. (PubMed id 18172262)^{1, 3} Hutterer M....Ullrich A. (2008)
Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. (PubMed id 15958209)^{1, 3} Valverde P. (2005)
Expression of axl in lung adenocarcinoma and correlation with tumor progression. (PubMed id 16354588)^{1, 3} Shieh Y.S....Wu C.W. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 558	HGNC: 905	AceView: AXL	Ensembl:ENSG00000167601	euGenes: HUgn558
ECgene: AXL	H-InvDB: AXL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AXL	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AXL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AXL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AXL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AXL		Antibodies for AXL
	Explore super-pooled esiRNAs		Proteins for AXL
	Lentivirus-delivered shRNAs for AXL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AXL)
	Antibodies (AXL)
	Chimera RNAi (AXL)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for AXL

	Recombinant Proteins (Axl)
	Antibodies (Axl)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for AXL

	Proteins for AXL
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AXL

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AXL Gene at Home site.
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AXL Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for AXL

Summaries
for AXL

Genomic Location
for AXL

Proteins
for AXL

Protein Domains/
Families
for AXL

Gene Function
for AXL

Pathways & Interactions
for AXL

Drugs & Compounds
for AXL

Transcripts
for AXL

Expression
for AXL

Orthologs
for AXL

Paralogs
for AXL

SNPs/Variants
for AXL

Disorders & Mutations
for AXL

Medical News
for AXL

Publications
for AXL

Search for AXL

Genome Databases showing AXL

Other Databases showing AXL

Specialized Databases showing AXL

Licensable Technologies
for AXL

Services
for AXL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AXL Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor AXL

Summariesfor AXL

Genomic Locationfor AXL

Proteinsfor AXL

Protein Domains/Familiesfor AXL

Gene Functionfor AXL

Pathways & Interactionsfor AXL

Drugs & Compoundsfor AXL

Transcriptsfor AXL

Expression for AXL

Orthologsfor AXL

Paralogsfor AXL

SNPs/Variantsfor AXL

Disorders & Mutationsfor AXL

Medical Newsfor AXL

Publicationsfor AXL

Search for AXL

Genome Databases showing AXL

Other Databases showing AXL

Specialized Databases showing AXL

Licensable Technologiesfor AXL

Servicesfor AXL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AXL

Summaries
for AXL

Genomic Location
for AXL

Proteins
for AXL

Protein Domains/
Families
for AXL

Gene Function
for AXL

Pathways & Interactions
for AXL

Drugs & Compounds
for AXL

Transcripts
for AXL

Expression
for AXL

Orthologs
for AXL

Paralogs
for AXL

SNPs/Variants
for AXL

Disorders & Mutations
for AXL

Medical News
for AXL

Publications
for AXL

Licensable Technologies
for AXL

Services
for AXL