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AXIN2 Gene

protein-coding GIFtS: 62

GC17M060956

axin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AXIL ^²
Axil ^³
Conductin ^³
DKFZp781B0869 ^¹, ²
MGC10366 ^²
MGC126582 ^¹, ²
conductin ^²

Descriptions
Axin-like protein ^³
Axis inhibition protein 2 ^³
axin 2 ^²

External Ids
HGNC: 904¹
Entrez Gene: 8313²
UniProtKB: Q9Y2T1³
Ensembl: ENSG00000168646⁷

Search outside databases for aliases for AXIN2 gene

Previous GC identifers: GC17P064858 GC17P067924 GC17M063942 GC17M064074

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for AXIN2:

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the

stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse

conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous

polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads

to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important

event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a

region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other

tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch

repair. [provided by RefSeq]

UniProtKB/Swiss-Prot: AXN2_HUMAN, Q9Y2T1

Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate

the phosphorylation of beta-catenin and APC by GSK3B (By similarity)

Gene Wiki entry for AXIN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AXIN2 gene

Entrez Gene cytogenetic band: 17q23-q24 Ensembl cytogenetic band: 17q24.1 HGNC cytogenetic band: 17q23-q24

AXIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M060956: (about GC identifiers)

Start:	60,955,143 bp from pter
End:	60,988,227 bp from pter
Size:	33,085 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AXN2_HUMAN, Q9Y2T1 (See protein sequence)

Recommended Name: Axin-2

Size: 843 amino acids; 93558 Da

Subunit: Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction

between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By

similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6

Subcellular location: Cytoplasm

Secondary accessions: Q3MJ88 Q9H3M6 Q9UH84

Post-translational modifications:

Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004646.3

ENSEMBL proteins:

ENSP00000364854 ENSP00000302625

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Axin 2)
	Human Recombinant Proteins from Abnova (AXIN2)

OriGene Purified Recombinant Human Protein: AXIN2

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	12072559
GO:0005737	cytoplasm	IEA	--

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Antibodies for AXIN2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for AXIN2
	Antibodies from Abcam (Axin 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for AXIN2

Assays for AXIN2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9Y2T1

ProtoNet protein and cluster: Q9Y2T1

1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: AXN2_HUMAN, Q9Y2T1

Similarity: Contains 1 DIX domain

Similarity: Contains 1 RGS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AXIN2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004655

Applied Biosystems Silencer® siRNAs for AXIN2

Sigma-Aldrich siRNA and siRNA Panels for AXIN2

Sigma-Aldrich shRNA for AXIN2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AXIN2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004655
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004655
untagged cDNA clones in CMV expression vector (see all 3): BC006295

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004655

UniProtKB/Swiss-Prot: AXN2_HUMAN, Q9Y2T1

Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate

the phosphorylation of beta-catenin and APC by GSK3B (By similarity)

Genatlas biochemistry entry for AXIN2:

axin 2,murine conduction homolog,negative regulator of the Wnt signaling pathway,promoting the

GSK3B dependent phosphorylation of beta catenin (CTNNB1) strong candidate in multiple tumor types

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Axin2):

craniofacial

endocrine/exocrine gland

reproductive system

skeleton

vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for AXIN2 (Your Favorite Gene powered by Ingenuity)

Wnt/&beta

GeneDecks AXIN2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AXIN2

5/54 Interacting proteins for AXIN2 (ENSP00000302625³) via UniProtKB, MINT, and/or STRING (see all 54 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNNB1	ENSP00000344456³	STRING (score=.999)
GSK3B	ENSP00000324806³	STRING (score=.993)
APC	ENSP00000257430³	STRING (score=.982)
LEF1	ENSP00000265165³	STRING (score=.979)
CSNK1E	ENSP00000352929³	STRING (score=.976)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001756	somitogenesis	IEA	--
GO:0001957	intramembranous ossification	IEA	--
GO:0007165	signal transduction	TAS	10049590
GO:0007275	multicellular organismal development	IEA	--
GO:0008285	negative regulation of cell proliferation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AXIN2
3 Novoseek chemical compound relationships for AXIN2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
samp	83.21	2	10021369 (1), 10966653 (1)
glycogen	48.32	4	16426922 (1), 11212302 (1), 10526234 (1), 10021369 (1)
threonine	11.43	2	11809809 (1), 10911903 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AXIN2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004655

Sigma-Aldrich siRNA and siRNA Panels for AXIN2

Sigma-Aldrich shRNA for AXIN2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004655

REFSEQ mRNAs for AXIN2 gene:

NM_004655.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004655

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004655
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004655
                                 untagged cDNA clones in CMV expression vector (see all 3): BC006295

Additional cDNA sequence:

AB052751.1 AF078165.1 AF205888.1 AK025718.1 AK315303.1 BC101533.1 BC143244.1 CR933657.1

6 DOTS entries:

DT.312900 DT.100773386 DT.95160596 DT.97809731 DT.100727598 DT.95197789

24/147 AceView cDNA sequences (see all 147 ):

AI024641 BQ438096 AI824380 BE670767 CK300336 AA932035 AA897688 AI263962

AW104413 AW779070 BU156663 AW009558 AI912345 CB306601 AA972819 BM974846

BM771508 BM468571 BM770270 BM745159 AA604626 BX956772 AA921892 AA918343

highest scoring ESTs for AXIN2:

AI660889 AI818109 AW016690 BI488624 BI913880 BM468571 AA305361 AA325695 AA341377 AA446378

Unigene Cluster for AXIN2:

Axin 2

Hs.156527 [show with all ESTs]

Unigene Representative Sequence: CR933657

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for AXIN2

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12
SP1:
SP2:
SP3:
SP4:															-

About this scheme

ECgene alternative splicing isoforms for AXIN2

2 Ensembl transcripts including schematic representations:

ENST00000375702 ENST00000307078

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AXIN2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AXIN2

¹ / ² / ³

11 probe-sets matching AXIN2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59763_s_at²^{, 3}	U95-C	1	1.00	1.00	0.85	1.10	AW016690	0.80	1.00	0.91	1
64129_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.21	AI660889	0.80	1.00	0.91	1
90101_at²^{, 3}	U95-E	1	1.00	1.00	-0.36	0.71	AI818109	0.80	1.00	0.91	1
224498_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC006295	0.40	1.00	0.76	1
224176_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF205888	0.60	1.00	0.82	1
222696_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF684446	0.60	1.00	0.82	1
222695_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI818109	0.80	1.00	0.91	1
224498_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224176_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222696_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222695_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AXIN2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACATTTTGTT

SOURCE GeneReport for Unigene cluster: Hs.156527
UniProtKB/Swiss-Prot: AXN2_HUMAN, Q9Y2T1
Tissue specificity: Expressed in brain and lymphoblast

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for AXIN2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AXIN2¹	--	axin 2	90.67(n) 92.88(a)	490903 XM_548025.2 XP_548025.2
chimpanzee (Pan troglodytes)	AXIN2¹	--	axin 2	99.37(n) 99.41(a)	468301 XM_001162941.1 XP_001162941.1
cow (Bos taurus)	AXIN2¹	--	axin 2	80.47(n) 81.14(a)	511619 XM_588992.3 XP_588992.3
rat (Rattus norvegicus)	Axin2¹	--	axin2	86.2(n) 90.45(a)	29134 NM_024355.1 NP_077331.1
mouse (Mus musculus)	Axin2^{1, 5}	11 (70.00 cM)⁵	axin2^{1, 5}	86.16(n)¹ 90.45(a)¹	12006¹ NM_015732.3¹ NP_056547.3¹ AA990118⁵ AF073788⁵ (see all 15)

About this table Species with no ortholog for AXIN2

ENSEMBL Gene Tree for AXIN2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AXIN2 gene

AXIN1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/184 NCBI SNPs in AXIN2 are shown (see all 184 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 76)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7591^1,2	A,C,F,H,O	60955544(+)	`CGAACA/TTCAAA`	1	--	ut3¹		14		MN EU EA WA NA	1424
	rs2240308^1,2	A,C,F,H	60985053(+)	`GACAGG/ACATGG`	1	S/P	mis¹		8		EU EA WA NA	778
--	rs10438779^1,2	A,C	60955762(+)	`CATGAG/TGGGGA`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs4791168^1,2	A	60990132(-)	`CACAGC/TCCCTT`	1	--	ng3¹		0	--	--	--	--
--	rs8081536^1,2	H	60964913(+)	`GCAGGC/TGGTGG`	1	R/H	mis¹ ese³		4		EU EA WA	406
	rs2240307^1,2	F,H	60984769(+)	`GAGACA/GATGCT`	1	I/I	syn¹ ese³		4		EU EA WA	418
	rs1133683^1,2	A,C	60964230(-)	`AGCCCC/TCGCTC`	1	P/P	syn¹ ese³		0	--	--	--	--
	rs35415678^1,2	F	60962979(-)	`CTCCCC/TTGACC`	1	L/L	syn¹		1		EU	192
--	rs9915936^1,2	C	60964251(+)	`ACGCCC/TGGAGA`	1	P/P	syn¹ ese³		0	--	--	--	--
	rs4074947^1,2	A,C,F,H	60957682(-)	`TCCCTC/TTGTGA`	1	--	int¹ trp³		12		EU EA WA NA	994

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HapMap Linkage Disequilibrium images for AXIN2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604025 disorders: 114500 608615

UniProtKB/Swiss-Prot: AXN2_HUMAN, Q9Y2T1

Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be

specifically associated with defective mismatch repair

Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome [MIM:608615].

Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions

of variable types

10/14 Novoseek disease relationships for AXIN2 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis	84.51	5	16426922 (1), 11212302 (1), 11752446 (1), 14970870 (1) (see all 5)
colorectal cancer	56.55	5	16941501 (2), 17927870 (1), 18843029 (1), 11474173 (1)
colon cancer	55.36	4	16815967 (2), 11752446 (1), 17143297 (1)
hepatoblastoma	45.37	4	15538750 (1), 15958610 (1)
polyposis	41.02	1	16941501 (1)
colon tumor	37.92	3	11752446 (2), 16815967 (1)
colon carcinoma	37.78	3	16815967 (1), 10911903 (1)
medulloblastoma	36.10	2	17373666 (1)
adenoma	30.11	4	16941501 (3), 18843029 (1)
somatic mutations	29.49	1	17258725 (1)

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Human Gene Mutation Database: AXIN2
Human Genome Epidemiology Navigator: AXIN2 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/71 PubMed articles for AXIN2 gene (see all 71 ):

Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. (PubMed id 10049590)^{1, 2, 3, 4} Mai M.... Liu W. (1999)
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. (PubMed id 16601693)^{3, 4} Liu W.... Lin S.-C. (2006)
Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. (PubMed id 16820935)^{3, 4} Kanzaki H....Shimizu K. (2006)
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (PubMed id 15042511)^{3, 4} Lammi L.... Nieminen P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. (PubMed id 11017067)^{3, 4} Liu W.... Thibodeau S.N. (2000)
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. (PubMed id 17373666)^{1, 3} Koch A....Pietsch T. (2007)
Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. (PubMed id 16941501)^{1, 3} Lejeune S....Buisine M.P. (2006)
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. (PubMed id 10966653)^{1, 3} von Kries J.P.... Birchmeier W. (2000)
Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. (PubMed id 18708403)^{1, 3} Wang X....Couch F.J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8313	HGNC: 904	AceView: AXIN2	Ensembl:ENSG00000168646	euGenes: HUgn8313
ECgene: AXIN2	H-InvDB: AXIN2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for AXIN2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AXIN2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AXIN2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AXIN2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AXIN2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AXIN2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies & Assays for AXIN2

	Recombinant Proteins (Axin 2)
	Antibodies (Axin 2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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AXIN2 Gene at Home site.
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AXIN2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for AXIN2

Summaries
for AXIN2

Genomic Location
for AXIN2

Proteins
for AXIN2

Protein Domains/
Families
for AXIN2

Gene Function
for AXIN2

Pathways & Interactions
for AXIN2

Drugs & Compounds
for AXIN2

Transcripts
for AXIN2

Expression
for AXIN2

Orthologs
for AXIN2

Paralogs
for AXIN2

SNPs/Variants
for AXIN2

Disorders & Mutations
for AXIN2

Medical News
for AXIN2

Publications
for AXIN2

Search for AXIN2

Genome Databases showing AXIN2

Other Databases showing AXIN2

Specialized Databases showing AXIN2

Licensable Technologies
for AXIN2

Services
for AXIN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AXIN2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor AXIN2

Summariesfor AXIN2

Genomic Locationfor AXIN2

Proteinsfor AXIN2

Protein Domains/Familiesfor AXIN2

Gene Functionfor AXIN2

Pathways & Interactionsfor AXIN2

Drugs & Compoundsfor AXIN2

Transcriptsfor AXIN2

Expression for AXIN2

Orthologsfor AXIN2

Paralogsfor AXIN2

SNPs/Variantsfor AXIN2

Disorders & Mutationsfor AXIN2

Medical Newsfor AXIN2

Publicationsfor AXIN2

Search for AXIN2

Genome Databases showing AXIN2

Other Databases showing AXIN2

Specialized Databases showing AXIN2

Licensable Technologiesfor AXIN2

Servicesfor AXIN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AXIN2

Summaries
for AXIN2

Genomic Location
for AXIN2

Proteins
for AXIN2

Protein Domains/
Families
for AXIN2

Gene Function
for AXIN2

Pathways & Interactions
for AXIN2

Drugs & Compounds
for AXIN2

Transcripts
for AXIN2

Expression
for AXIN2

Orthologs
for AXIN2

Paralogs
for AXIN2

SNPs/Variants
for AXIN2

Disorders & Mutations
for AXIN2

Medical News
for AXIN2

Publications
for AXIN2

Licensable Technologies
for AXIN2

Services
for AXIN2