Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AXIN2 Gene

protein-coding   GIFtS: 65
GCID: GC17M063524

Axin 2

  See AXIN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Axin 21 2     axil1
conductin1 2     AXIL2
Axin-Like Protein2 3     axin-22
Axis Inhibition Protein 22 3     Axil3
ODCRCS2 5     Conductin3

External Ids:    HGNC: 9041   Entrez Gene: 83132   Ensembl: ENSG000001686467   OMIM: 6040255   UniProtKB: Q9Y2T13   

Export aliases for AXIN2 gene to outside databases

Previous GC identifers: GC17P064858 GC17P067924 GC17M063942 GC17M064074 GC17M060956 GC17M058916


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AXIN2 Gene:
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of
beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse,
conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen
synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the
deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has
been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma,
and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch
repair. (provided by RefSeq, Jul 2008)

GeneCards Summary for AXIN2 Gene:
AXIN2 (axin 2) is a protein-coding gene. Diseases associated with AXIN2 include axin2-related attenuated familial adenomatous polyposis, and oligodontia-colorectal cancer syndrome. GO annotations related to this gene include protein kinase binding and enzyme binding. An important paralog of this gene is AXIN1.

UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the
phosphorylation of beta-catenin and APC by GSK3B (By similarity)

Gene Wiki entry for AXIN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AXIN2 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   HNF-4alpha2   c-Jun   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAXIN2 promoter sequence
   Search Chromatin IP Primers for AXIN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AXIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23-q24   Ensembl cytogenetic band:  17q24.1   HGNC cytogenetic band: 17q23-q24

AXIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AXIN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M063524:  view genomic region     (about GC identifiers)

Start:
63,524,681 bp from pter      End:
63,557,765 bp from pter
Size:
33,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1 (See protein sequence)
Recommended Name: Axin-2  
Size: 843 amino acids; 93558 Da
Subunit: Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and
beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and
RNF111. Interacts with ANKRD6
Secondary accessions: Q3MJ88 Q9H3M6 Q9UH84

Explore the universe of human proteins at neXtProt for AXIN2: NX_Q9Y2T1

Explore proteomics data for AXIN2 at MOPED

Post-translational modifications: 

  • Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity)1
  • ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by
    ubiquitination and subsequent activation of the Wnt signaling pathway1
  • Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt
    signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step:
    deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AXIN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004646.3  
    ENSEMBL proteins: 
     ENSP00000302625   ENSP00000364854   ENSP00000464264   ENSP00000463761   ENSP00000463192  
     ENSP00000441151  
    Reactome Protein details: Q9Y2T1

    AXIN2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AXIN2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AXIN2
    GenScript Custom Purified and Recombinant Proteins Services for AXIN2
    Novus Biologicals AXIN2 Proteins
    Novus Biologicals AXIN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AXIN2

     
    Search eBioscience for Proteins for AXIN2 

     
    antibodies-online proteins for AXIN2 (7 products) 

     
    antibodies-online peptides for AXIN2

    AXIN2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AXIN2
    R&D Systems Antibodies for AXIN2 (Axin-2)
    Cell Signaling Technology (CST) Antibodies for AXIN2  (axin 2)
    OriGene Antibodies for AXIN2
    OriGene Custom Antibody Services for AXIN2
    Novus Biologicals AXIN2 Antibodies
    Search for Antibodies for AXIN2 at Abcam
    Cloud-Clone Corp. Antibodies for AXIN2
    ThermoFisher Antibody for AXIN2
    antibodies-online antibodies for AXIN2 (39 products) 

    AXIN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AXIN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AXIN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AXIN2
    Cloud-Clone Corp. CLIAs for AXIN2
    Search eBioscience for ELISAs for AXIN2 
    antibodies-online kits for AXIN2 (24 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR001158 DIX
     IPR014936 Axin_b-cat-bd
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2T1

    ProtoNet protein and cluster: Q9Y2T1

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
    Domain: The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2 (By
    similarity)
    Similarity: Contains 1 DIX domain
    Similarity: Contains 1 RGS domain


    Find genes that share domains with AXIN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AXIN2_HUMAN, Q9Y2T1
    Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the
    phosphorylation of beta-catenin and APC by GSK3B (By similarity)

         Genatlas biochemistry entry for AXIN2:
    axin 2,murine conduction homolog,negative regulator of the Wnt signaling pathway,promoting the GSK3B dependent
    phosphorylation of beta catenin (CTNNB1) strong candidate in multiple tumor types

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI10698523
    GO:0008013beta-catenin binding NAS11017067
    GO:0019899enzyme binding IPI19759537
         
    Find genes that share ontologies with AXIN2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AXIN2:
     Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Axin2):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis  normal 
     reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with AXIN2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AXIN2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AXIN2:
    hsa-mir-103a-3p (MIRT027137), hsa-mir-34a-5p (MIRT001232), hsa-mir-16-5p (MIRT006751)

    Block miRNA regulation of human, mouse, rat AXIN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AXIN2 (see all 49):
    hsa-miR-562 hsa-miR-607 hsa-miR-4307 hsa-miR-3141 hsa-miR-15a hsa-miR-374a hsa-miR-3074-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidAXIN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AXIN2
    Predesigned siRNA for gene silencing in human, mouse, rat AXIN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AXIN2

    Clone
    Products:
         
    OriGene clones in human, mouse for AXIN2 (see all 8)
    OriGene ORF clones in mouse, rat for AXIN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AXIN2 (NM_004655)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AXIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXIN2
    Addgene plasmids for AXIN2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AXIN2
    Browse ESI BIO Cell Lines and PureStem Progenitors for AXIN2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXIN2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10388) for AXIN2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AXIN2_HUMAN, Q9Y2T1: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    plasma membrane3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA12072559
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005881cytoplasmic microtubule IBA--

    Find genes that share ontologies with AXIN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AXIN2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    5Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35


    Find genes that share SuperPaths with AXIN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for AXIN2
        Wnt Signaling Pathways
    Apoptosis Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AXIN2
        Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for AXIN2
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for AXIN2
        Cytoskeleton remodeling Reverse signaling by ephrin B

    Selected BioSystems Pathways for AXIN2 (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    Canonical Wnt signaling pathway

    3 Reactome Pathways for AXIN2
        degradation of AXIN
    binding of TCF/LEF:CTNNB1 to target gene promoters
    TCF dependent signaling in response to WNT


    Selected Kegg Pathways  (Kegg details for AXIN2) (see all 6):
        Wnt signaling pathway
    Hippo signaling pathway
    Pathways in cancer
    Colorectal cancer
    Endometrial cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AXIN2: 
              WNT Signaling Targets in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AXIN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AXIN2 (Q9Y2T11, 2, 3 ENSP000003026254) via UniProtKB, MINT, STRING, and/or I2D (see all 208)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627141, 2, 3, ENSP000002211384EBI-4400025,EBI-1044367 MINT-8285087 MINT-8285094 MINT-8285108 MINT-8285117 I2D: score=2 STRING: ENSP00000221138
    GSK3BP498413, ENSP000003248064I2D: score=7 STRING: ENSP00000324806
    APCP250543, ENSP000002574304I2D: score=4 STRING: ENSP00000257430
    CSNK1EP496743, ENSP000003529294I2D: score=1 STRING: ENSP00000352929
    GSK3AP498403, ENSP000002223304I2D: score=1 STRING: ENSP00000222330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001756somitogenesis ----
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0001957intramembranous ossification IBA--
    GO:0003413chondrocyte differentiation involved in endochondral bone morphogenesis IEA--
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with AXIN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AXIN2

    5 Novoseek inferred chemical compound relationships for AXIN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pidotimod 85.2 9 10647780 (4), 11809809 (1), 10049590 (1), 11438668 (1)
    samp 82.3 2 10021369 (1), 10966653 (1)
    glycogen 50.4 4 16426922 (1), 11212302 (1), 10526234 (1), 10021369 (1)
    threonine 22.7 3 11809809 (1), 10911903 (1), 20300119 (1)
    serine 6.95 3 11809809 (1), 10911903 (1), 20300119 (1)



    Find genes that share compounds with AXIN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AXIN2 gene: 
    NM_004655.3  

    Unigene Cluster for AXIN2:

    Axin 2
    Hs.156527  [show with all ESTs]
    Unigene Representative Sequence: CR933657
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307078(uc002jfh.3 uc002jfi.3) ENST00000375702 ENST00000578251
    ENST00000577278 ENST00000580513 ENST00000585045(uc002jfj.1) ENST00000544103

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AXIN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AXIN2 (see all 49):
    hsa-miR-562 hsa-miR-607 hsa-miR-4307 hsa-miR-3141 hsa-miR-15a hsa-miR-374a hsa-miR-3074-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidAXIN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AXIN2
    Predesigned siRNA for gene silencing in human, mouse, rat AXIN2
    Clone
    Products:
         
    OriGene clones in human, mouse for AXIN2 (see all 8)
    OriGene ORF clones in mouse, rat for AXIN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AXIN2 (NM_004655)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AXIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXIN2
    Addgene plasmids for AXIN2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AXIN2
    OriGene qSTAR qPCR primer pairs in human, mouse for AXIN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AXIN2
      QuantiTect SYBR Green Assays in human, mouse, rat AXIN2
      QuantiFast Probe-based Assays in human, mouse, rat AXIN2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10388) for AXIN2 

    Additional mRNA sequence: 

    AB052751.1 AF078165.1 AF205888.1 AK025718.1 AK315303.1 BC101533.1 BC143244.1 CR933657.1 

    6 DOTS entries:

    DT.312900  DT.100773386  DT.95160596  DT.97809731  DT.100727598  DT.95197789 

    Selected AceView cDNA sequences (see all 147):

    BM771508 BU156663 BM468571 CB306601 AI824380 BQ064642 AA918343 AI263962 
    CK300336 BM770270 AI912345 AA932035 AA897688 AA921892 AW009558 BM974846 
    AW779070 AA604626 AW104413 AA972819 AI024641 BX956772 BQ438096 BE670767 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AXIN2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                            -                                       


    ECgene alternative splicing isoforms for AXIN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AXIN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTTTGTT
    AXIN2 Expression
    About this image


    AXIN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Odontoblasts Dentin
             Dental Papilla
     
     Dermis (Integumentary System)    fully expand to see all 4 entries
             Dermal Fibroblasts Dorsal Dermis
             Dental Papilla
     
     Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
    AXIN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AXIN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156527

    UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
    Tissue specificity: Expressed in brain and lymphoblast

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AXIN2: 
              WNT Signaling Targets in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AXIN2
    OriGene qSTAR qPCR primer pairs in human, mouse for AXIN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AXIN2
    QuantiTect SYBR Green Assays in human, mouse, rat AXIN2
    QuantiFast Probe-based Assays in human, mouse, rat AXIN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXIN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for AXIN2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Axin21 , 5 axin21, 5 86.2(n)1
    90.57(a)1
      11 (71.83 cM)5
    120061  NM_015732.41  NP_056547.31 
     1089203495 
    chicken
    (Gallus gallus)
    Aves AXIN21 axin 2 77.01(n)
    81.33(a)
      395152  NM_204491.1  NP_989822.1 
    lizard
    (Anolis carolinensis)
    Reptilia AXIN26
    axin 2
    78(a)
    1 ↔ 1
    GL343260.1(882505-926506)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58332 Transcribed sequence with weak similarity to protein more 77.39(n)    BX739698.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB032263.12   -- 76.63(n)   58080  AB032263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Axn6
    Axin
    23(a)
    1 → many
    3R(25848566-25861033)


    ENSEMBL Gene Tree for AXIN2 (if available)
    TreeFam Gene Tree for AXIN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AXIN2 gene
    AXIN12  
    5 SIMAP similar genes for AXIN2 using alignment to 7 protein entries:     AXIN2_HUMAN (see all proteins):
    DKFZp781B0869    AXIN1    RGS10    RGS20    RGS3

    Find genes that share paralogs with AXIN2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for AXIN2
    PGOHUM00000259798


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AXIN2 (see all 843)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22403081,2,,4
    C,F,A,HPolymorphism associated with increased risk of lung cancer4 --58946638(+) GACAGG/ACATGG 2 /P /S mis127Minor allele frequency- A:0.36NS EA NA EU 8476
    rs762661161,2
    C,F--58916274(+) GCCTTG/ATTGAT 1 -- ds50011Minor allele frequency- A:0.06EA 120
    rs1432434891,2
    C--58916388(+) ATGTCA/GGAGAC 1 -- ds50010--------
    rs1163382081,2
    F--58916463(+) CTGGAG/AACAAT 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1836074551,2
    --58916472(+) ATCTGC/TCCAGG 1 -- ds50010--------
    rs620634371,2
    C,F--58916483(+) AGGAAG/AAGGCT 1 -- ds50012Minor allele frequency- A:0.09NA EA 240
    rs1887168071,2
    --58916566(+) CCTCAA/GCCAGT 1 -- ds50010--------
    rs1478744591,2
    --58916619(+) GGGTCC/TAGATC 1 -- ds50010--------
    rs620634381,2
    F--58916621(+) GTCCAG/CATCAG 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs733462761,2
    C,F--58916648(+) AGAGAC/GGGGCT 1 -- ds50012Minor allele frequency- G:0.06WA 120

    HapMap Linkage Disequilibrium report for AXIN2 (63524681 - 63557765 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AXIN2: --
    Human Gene Mutation Database (HGMD): AXIN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AXIN2
    DNA2.0 Custom Variant and Variant Library Synthesis for AXIN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604025   
    OMIM disorders: 608615  114500  
    UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry is involved in disease pathogenesis
  • Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth
    agenesis and colorectal cancer or precancerous lesions of variable types. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 11 diseases for AXIN2:    
    About MalaCards
    axin2-related attenuated familial adenomatous polyposis    oligodontia-colorectal cancer syndrome    colorectal cancer, somatic    tooth agenesis, selective, 1, with or without orofacial cleft
    familial melanoma    tooth agenesis    orofacial cleft    familial adenomatous polyposis
    colorectal cancer    neuroblastoma    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for AXIN2:
    Tooth agenesis     Familial adenomatous polyposis     Colorectal cancer

    Find genes that share disorders with AXIN2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AXIN2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 86 5 16426922 (1), 11212302 (1), 11752446 (1), 14970870 (1) (see all 5)
    polyposis 57.5 1 16941501 (1)
    colorectal cancer 56.5 7 17927870 (2), 16941501 (2), 19454286 (1), 18843029 (1) (see all 5)
    colon cancer 53.7 4 16815967 (2), 11752446 (1), 17143297 (1)
    hepatoblastoma 44 4 15538750 (1), 15958610 (1)
    colon tumor 36.5 3 11752446 (2), 16815967 (1)
    colon carcinoma 36.4 3 16815967 (1), 10911903 (1)
    adenoma 35.2 4 16941501 (3), 18843029 (1)
    medulloblastoma 34.4 2 17373666 (1)
    somatic mutations 27.9 1 17258725 (1)

    Genetic Association Database (GAD): AXIN2
    Human Genome Epidemiology (HuGE) Navigator: AXIN2 (21 documents)

    Export disorders for AXIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AXIN2 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with AXIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. (PubMed id 10049590)1, 2, 3, 9 Mai M.... Liu W. (Genomics 1999)
    2. Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. (PubMed id 16820935)1, 2, 4 Kanzaki H.... Shimizu K. (Int. J. Mol. Med. 2006)
    3. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. (PubMed id 18708403)1, 4, 9 Wang X....Couch F.J. (amp 2008)
    4. Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. (PubMed id 16432638)1, 4, 9 Mostowska A....Jagodzinski P.P. (J. Hum. Genet. 2006)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PubMed id 21383061)1, 2 Lui T.T.... Angers S. (Mol. Cell. Biol. 2011)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (Menopause 2010)
    9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    10. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8313 HGNC: 904 AceView: AXIN2 Ensembl:ENSG00000168646 euGenes: HUgn8313
    ECgene: AXIN2 Kegg: 8313 H-InvDB: AXIN2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AXIN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AXIN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AXIN2 gene:
    Search GeneIP for patents involving AXIN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AXIN2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for AXIN2 (Axin-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AXIN2   OriGene RNAi products in human, mouse, rat for AXIN2  
     OriGene qPCR primer pairs and template standards for AXIN2   OriGene Protein Over-expression Lysate for AXIN2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AXIN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AXIN2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AXIN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AXIN2   OriGene Custom Protein Services for AXIN2  

     
     
     Block miRNA regulation of human, mouse, rat AXIN2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AXIN2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AXIN2 Predesigned siRNA for gene silencing in human, mouse, rat AXIN2
     QuantiFast Probe-based Assays in human, mouse, rat AXIN2 QuantiTect SYBR Green Assays in human, mouse, rat AXIN2
     PCR Arrays including human, mouse, rat AXIN2 Search Chromatin IP Primers for AXIN2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AXIN2  GeneGlobe Interaction Network for AXIN2
     Regulatory tfbs in AXIN2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AXIN2 GenScript cDNA clones with any tag delivered in your preferred vector for AXIN2
     GenScript Custom Assay Services for AXIN2 GenScript Custom overexpressing Cell Line Services for AXIN2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for AXIN2 
    (axin 2)

     Search Tocris compounds for AXIN2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AXIN2 antibodies
     AXIN2 proteins
     AXIN2 lysates
     Search for Antibodies for AXIN2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AXIN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AXIN2
     Antibodies for AXIN2
     ELISAs for AXIN2
     CLIAs for AXIN2



     Browse ESI BIO Cell Lines and PureStem Progenitors for AXIN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXIN2
     SwitchGear 3'UTR luciferase reporter plasmids for AXIN2
     SwitchGear Promoter luciferase reporter plasmids for AXIN2
     ThermoFisher Antibody for AXIN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXIN2
     Browse compounds at ApexBio
     Addgene plasmids for AXIN2
      Search eBioscience for proteins for AXIN2
      Search eBioscience for elisas for AXIN2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for AXIN2
     antibodies-online antibodies for AXIN2 (39 products)
     antibodies-online kits for AXIN2 (24 products)
     antibodies-online peptides for AXIN2
     antibodies-online proteins for AXIN2 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AXIN2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4