Aliases for AXIN2 Gene
External Ids for AXIN2 Gene
Previous GeneCards Identifiers for AXIN2 Gene
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for AXIN2 Gene
AXIN2 (Axin 2) is a Protein Coding gene. Diseases associated with AXIN2 include Oligodontia-Colorectal Cancer Syndrome and Axin2-Related Attenuated Familial Adenomatous Polyposis. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Mesodermal Commitment Pathway. GO annotations related to this gene include protein kinase binding and GTPase activator activity. An important paralog of this gene is AXIN1.
UniProtKB/Swiss-Prot for AXIN2 Gene
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).