Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AXIN2 Gene

protein-coding   GIFtS: 66
GCID: GC17M063524

Axin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Axin 21 2     AXIL2
conductin1 2     ODCRCS2
Axin-Like Protein2 3     axin-22
Axis Inhibition Protein 22 3     Axil3
axil1     Conductin3

External Ids:    HGNC: 9041   Entrez Gene: 83132   Ensembl: ENSG000001686467   OMIM: 6040255   UniProtKB: Q9Y2T13   

Export aliases for AXIN2 gene to outside databases

Previous GC identifers: GC17P064858 GC17P067924 GC17M063942 GC17M064074 GC17M060956 GC17M058916


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AXIN2 Gene:
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of
beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse,
conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen
synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the
deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has
been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma,
and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch
repair. (provided by RefSeq, Jul 2008)

GeneCards Summary for AXIN2 Gene: 
AXIN2 (axin 2) is a protein-coding gene. Diseases associated with AXIN2 include oligodontia-colorectal cancer syndrome, and anodontia, and among its related super-pathways are Wnt signaling pathway and Endometrial cancer. GO annotations related to this gene include protein kinase binding and enzyme binding. An important paralog of this gene is AXIN1.

UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the
phosphorylation of beta-catenin and APC by GSK3B (By similarity)

Gene Wiki entry for AXIN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AXIN2 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   HNF-4alpha2   c-Jun   PPAR-gamma2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAXIN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AXIN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AXIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23-q24   Ensembl cytogenetic band:  17q24.1   HGNC cytogenetic band: 17q23-q24

AXIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AXIN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M063524:  view genomic region     (about GC identifiers)

Start:
63,524,681 bp from pter      End:
63,557,765 bp from pter
Size:
33,085 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1 (See protein sequence)
Recommended Name: Axin-2  
Size: 843 amino acids; 93558 Da
Subunit: Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and
beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and
RNF111. Interacts with ANKRD6
Subcellular location: Cytoplasm
Secondary accessions: Q3MJ88 Q9H3M6 Q9UH84

Explore the universe of human proteins at neXtProt for AXIN2: NX_Q9Y2T1

Explore proteomics data for AXIN2 at MOPED 

Post-translational modifications:

  • UniProtKB: Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity)
  • UniProtKB: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by
    ubiquitination and subsequent activation of the Wnt signaling pathway
  • UniProtKB: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt
    signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step:
    deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2T1

  • AXIN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AXIN2 Protein Expression
    REFSEQ proteins: NP_004646.3  
    ENSEMBL proteins: 
     ENSP00000302625   ENSP00000364854   ENSP00000464264   ENSP00000463761   ENSP00000463192  
     ENSP00000441151  

    Human Recombinant Protein Products for AXIN2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AXIN2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AXIN2
    GenScript Custom Purified and Recombinant Proteins Services for AXIN2
    Novus Biologicals AXIN2 Proteins
    Novus Biologicals AXIN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AXIN2 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA12072559
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005881cytoplasmic microtubule IBA--

    AXIN2 for ontologies           About GeneDecksing



    AXIN2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AXIN2
    R&D Systems Antibodies for AXIN2 (Axin-2)
    Cell Signaling Technology (CST) Antibodies for AXIN2  (axin 2)
    OriGene Antibodies for AXIN2
    OriGene Custom Antibody Services for AXIN2
    GenScript Custom Superior Antibodies Services for AXIN2
    Novus Biologicals AXIN2 Antibodies
    Abcam antibodies for AXIN2
    Cloud-Clone Corp. Antibodies for AXIN2 
    ThermoFisher Antibody for AXIN2
    LSBio Antibodies in human, mouse, rat for AXIN2 

    Assay Products for AXIN2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AXIN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AXIN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AXIN2 
    Cloud-Clone Corp. CLIAs for AXIN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR014936 Axin_b-cat-bd
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam
     IPR001158 DIX

    Graphical View of Domain Structure for InterPro Entry Q9Y2T1

    ProtoNet protein and cluster: Q9Y2T1

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
    Domain: The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2 (By
    similarity)
    Similarity: Contains 1 DIX domain
    Similarity: Contains 1 RGS domain


    AXIN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AXIN2_HUMAN, Q9Y2T1
    Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the
    phosphorylation of beta-catenin and APC by GSK3B (By similarity)

         Genatlas biochemistry entry for AXIN2:
    axin 2,murine conduction homolog,negative regulator of the Wnt signaling pathway,promoting the GSK3B dependent
    phosphorylation of beta catenin (CTNNB1) strong candidate in multiple tumor types

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI10698523
    GO:0008013beta-catenin binding NAS11017067
    GO:0019899enzyme binding IPI19759537
         
    AXIN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AXIN2:
     Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Axin2):
     cardiovascular system  craniofacial  embryogenesis  endocrine/exocrine gland  limbs/digits/tail 
     mortality/aging  nervous system  normal  reproductive system  skeleton 
     vision/eye 

    AXIN2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AXIN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AXIN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AXIN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AXIN2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AXIN2:
    hsa-mir-34a (MIRT001232)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AXIN2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate AXIN2 (see all 49):
    hsa-miR-562 hsa-miR-607 hsa-miR-4307 hsa-miR-3141 hsa-miR-15a hsa-miR-374a hsa-miR-3074-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidAXIN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AXIN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AXIN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AXIN2
    Sirion Biotech Customized adenovirus for overexpression of AXIN2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AXIN2 (see all 8)
    OriGene ORF clones in mouse, rat for AXIN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AXIN2 (NM_004655)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AXIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXIN2
    Sirion Biotech Customized lentivirus for stable overexpression of AXIN2 
                         Customized lentivirus expression plasmids for stable overexpression of AXIN2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AXIN2
    Search LifeMap BioReagents cell lines for AXIN2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXIN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AXIN2 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    3Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    4Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency0.55
    5Basal cell carcinoma
    Basal cell carcinoma0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AXIN2
        Cytoskeleton remodeling Reverse signaling by ephrin B

    2 R&D Systems Pathways for AXIN2
        Wnt Signaling Pathway
    Apoptosis Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AXIN2
        Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for AXIN2
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for AXIN2
        Cytoskeleton remodeling Reverse signaling by ephrin B

    5/6 BioSystems Pathways for AXIN2 (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    Canonical Wnt signaling pathway


    5/6         Kegg Pathways  (Kegg details for AXIN2) (see all 6):
        Wnt signaling pathway
    Hippo signaling pathway
    Pathways in cancer
    Colorectal cancer
    Endometrial cancer


    AXIN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AXIN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/187 Interacting proteins for AXIN2 (Q9Y2T12, 3 ENSP000003026254) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627142, 3, ENSP000002211384MINT-8285087 MINT-8285094 MINT-8285108 MINT-8285117 I2D: score=2 STRING: ENSP00000221138
    GSK3BP498413, ENSP000003248064I2D: score=7 STRING: ENSP00000324806
    APCP250543, ENSP000002574304I2D: score=4 STRING: ENSP00000257430
    CSNK1EP496743, ENSP000003529294I2D: score=1 STRING: ENSP00000352929
    GSK3AP498403, ENSP000002223304I2D: score=1 STRING: ENSP00000222330
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001756somitogenesis ----
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0001957intramembranous ossification IBA--
    GO:0003413chondrocyte differentiation involved in endochondral bone morphogenesis IEA--
    GO:0007275multicellular organismal development ----

    AXIN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AXIN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AXIN2

    5 Novoseek inferred chemical compound relationships for AXIN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pidotimod 85.2 9 10647780 (4), 11809809 (1), 10049590 (1), 11438668 (1)
    samp 82.3 2 10021369 (1), 10966653 (1)
    glycogen 50.4 4 16426922 (1), 11212302 (1), 10526234 (1), 10021369 (1)
    threonine 22.7 3 11809809 (1), 10911903 (1), 20300119 (1)
    serine 6.95 3 11809809 (1), 10911903 (1), 20300119 (1)

    Search CenterWatch for drugs/clinical trials and news about AXIN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AXIN2 gene: 
    NM_004655.3  

    Unigene Cluster for AXIN2:

    Axin 2
    Hs.156527  [show with all ESTs]
    Unigene Representative Sequence: CR933657
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307078(uc002jfh.3 uc002jfi.3) ENST00000375702 ENST00000578251
    ENST00000577278 ENST00000580513 ENST00000585045(uc002jfj.1) ENST00000544103

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AXIN2
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate AXIN2 (see all 49):
    hsa-miR-562 hsa-miR-607 hsa-miR-4307 hsa-miR-3141 hsa-miR-15a hsa-miR-374a hsa-miR-3074-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidAXIN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AXIN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AXIN2
    Clone
    Products:
         
    OriGene clones in human, mouse for AXIN2 (see all 8)
    OriGene ORF clones in mouse, rat for AXIN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AXIN2 (NM_004655)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AXIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXIN2
    Sirion Biotech Customized lentivirus for stable overexpression of AXIN2 
                         Customized lentivirus expression plasmids for stable overexpression of AXIN2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AXIN2
    OriGene qSTAR qPCR primer pairs in human, mouse for AXIN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AXIN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AXIN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AXIN2

    Additional mRNA sequence: 

    AB052751.1 AF078165.1 AF205888.1 AK025718.1 AK315303.1 BC101533.1 BC143244.1 CR933657.1 

    6 DOTS entries:

    DT.312900  DT.100773386  DT.95160596  DT.97809731  DT.100727598  DT.95197789 

    24/147 AceView cDNA sequences (see all 147):

    AA918343 AA932035 BM468571 BU156663 CK300336 AW779070 AI263962 BM974846 
    AA972819 AI630818 BM770270 AA604626 BX956772 BE670767 BM745159 CB306601 
    AI912345 BM771508 AA921892 AW009558 AI024641 AI824380 BQ438096 BQ064642 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AXIN2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                            -                                       


    ECgene alternative splicing isoforms for AXIN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AXIN2 expression in normal human tissues (normalized intensities)      AXIN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTTTGTT
    AXIN2 Expression
    About this image


    AXIN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 5 entries
             Dermal Fibroblasts Dorsal Dermis
             limb/forelimb/fore-paw   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain/lateral wall   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm

    See AXIN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AXIN2

    SOURCE GeneReport for Unigene cluster: Hs.156527

    UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
    Tissue specificity: Expressed in brain and lymphoblast

        SABiosciences Expression via Pathway-Focused PCR Arrays including AXIN2: 
              WNT Signaling Targets in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AXIN2
    OriGene qSTAR qPCR primer pairs in human, mouse for AXIN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AXIN2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AXIN2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AXIN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXIN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AXIN2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Axin21 , 5 axin21, 5 86.24(n)1
    90.69(a)1
      11 (71.83 cM)5
    120061  NM_015732.41  NP_056547.31 
     1089203495 
    chicken
    (Gallus gallus)
    Aves AXIN21 axin 2 77.54(n)
    81.82(a)
      395152  NM_204491.1  NP_989822.1 
    lizard
    (Anolis carolinensis)
    Reptilia AXIN26
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343260.1(882505-926506)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58332 Transcribed sequence with weak similarity to protein more 77.39(n)    BX739698.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB032263.12   -- 76.63(n)   58080  AB032263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Axn6
    Axin
    21(a)
    1 → many
    3R(25848566-25861033)


    ENSEMBL Gene Tree for AXIN2 (if available)
    TreeFam Gene Tree for AXIN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AXIN2 gene
    AXIN12  
    5 SIMAP similar genes for AXIN2 using alignment to 7 protein entries:     AXIN2_HUMAN (see all proteins):
    DKFZp781B0869    AXIN1    RGS10    RGS20    RGS3

    AXIN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AXIN2
    PGOHUM00000259798


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/843 SNPs in AXIN2 are shown (see all 843)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22403081,2,4
    C,F,A,HPolymorphism associated with increased risk of lung cancer4 --58946638(+) GACAGG/ACATGG 2 /P /S mis127Minor allele frequency- A:0.36NS EA NA EU 8476
    rs762661161,2
    C,F--58916274(+) GCCTTG/ATTGAT 1 -- ds50011Minor allele frequency- A:0.06EA 120
    rs1432434891,2
    C--58916388(+) ATGTCA/GGAGAC 1 -- ds50010--------
    rs1163382081,2
    F--58916463(+) CTGGAG/AACAAT 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1836074551,2
    --58916472(+) ATCTGC/TCCAGG 1 -- ds50010--------
    rs620634371,2
    C,F--58916483(+) AGGAAG/AAGGCT 1 -- ds50012Minor allele frequency- A:0.09NA EA 240
    rs1887168071,2
    --58916566(+) CCTCAA/GCCAGT 1 -- ds50010--------
    rs1478744591,2
    --58916619(+) GGGTCC/TAGATC 1 -- ds50010--------
    rs620634381,2
    F--58916621(+) GTCCAG/CATCAG 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs733462761,2
    C,F--58916648(+) AGAGAC/GGGGCT 1 -- ds50012Minor allele frequency- G:0.06WA 120

    HapMap Linkage Disequilibrium report for AXIN2 (63524681 - 63557765 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AXIN2: --

    Human Gene Mutation Database (HGMD): AXIN2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AXIN2
    DNA2.0 Custom Variant and Variant Library Synthesis for AXIN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604025   
    OMIM disorders: 114500  608615  
    UniProtKB/Swiss-Prot: AXIN2_HUMAN, Q9Y2T1
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry is involved in disease pathogenesis
  • Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth
    agenesis and colorectal cancer or precancerous lesions of variable types. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/31 diseases for AXIN2 (see all 31):    About MalaCards
    oligodontia-colorectal cancer syndrome    anodontia    tooth agenesis, selective, 1, with or without orofacial cleft    tooth agenesis
    hepatoblastoma    colorectal cancer    merkel cell carcinoma    orofacial cleft
    familial adenomatous polyposis    neuroblastoma    hirschsprung's disease    medulloblastoma
    breast cancer    esophageal adenocarcinoma    basal cell carcinoma    duodenitis
    brain injury    colon cancer    adenoma    ovarian cancer

    3 diseases from the University of Copenhagen DISEASES database for AXIN2:
    Tooth agenesis     Familial adenomatous polyposis     Colorectal cancer

    AXIN2 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for AXIN2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 86 5 16426922 (1), 11212302 (1), 11752446 (1), 14970870 (1) (see all 5)
    polyposis 57.5 1 16941501 (1)
    colorectal cancer 56.5 7 17927870 (2), 16941501 (2), 19454286 (1), 18843029 (1) (see all 5)
    colon cancer 53.7 4 16815967 (2), 11752446 (1), 17143297 (1)
    hepatoblastoma 44 4 15538750 (1), 15958610 (1)
    colon tumor 36.5 3 11752446 (2), 16815967 (1)
    colon carcinoma 36.4 3 16815967 (1), 10911903 (1)
    adenoma 35.2 4 16941501 (3), 18843029 (1)
    medulloblastoma 34.4 2 17373666 (1)
    somatic mutations 27.9 1 17258725 (1)

    Genetic Association Database (GAD): AXIN2
    Human Genome Epidemiology (HuGE) Navigator: AXIN2 (21 documents)

    Export disorders for AXIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AXIN2 gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with AXIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. (PubMed id 10049590)1, 2, 3, 9 Mai M.... Liu W. (1999)
    2. Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. (PubMed id 16820935)1, 2, 4 Kanzaki H....Shimizu K. (2006)
    3. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. (PubMed id 18708403)1, 4, 9 Wang X....Couch F.J. (2008)
    4. Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. (PubMed id 16432638)1, 4, 9 Mostowska A....Jagodzinski P.P. (2006)
    5. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PubMed id 21383061)1, 2 Lui T.T.... Angers S. (2011)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    7. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    8. Association between polymorphisms in Wnt signaling pa thway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (2010)
    9. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    10. Single nucleotide polymorphisms in the Wnt and BMP pa thways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8313 HGNC: 904 AceView: AXIN2 Ensembl:ENSG00000168646 euGenes: HUgn8313
    ECgene: AXIN2 Kegg: 8313 H-InvDB: AXIN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AXIN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AXIN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AXIN2 gene:
    Search GeneIP for patents involving AXIN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AXIN2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for AXIN2 (Axin-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for AXIN2   OriGene RNAi products in human, mouse, rat for AXIN2  
     OriGene qPCR primer pairs and template standards for AXIN2   OriGene Protein Over-expression Lysate for AXIN2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AXIN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AXIN2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AXIN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AXIN2   OriGene Custom Protein Services for AXIN2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AXIN2
     QIAGEN SeqTarget long-range PCR primers for resequencing AXIN2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AXIN2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AXIN2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AXIN2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AXIN2
     GenScript Custom Purified and Recombinant Proteins Services for AXIN2 GenScript cDNA clones with any tag delivered in your preferred vector for AXIN2
     GenScript Custom Assay Services for AXIN2 GenScript Custom Superior Antibodies Services for AXIN2
     GenScript Custom overexpressing Cell Line Services for AXIN2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for AXIN2 
    (axin 2)

     Regulatory tfbs in AXIN2 promoter
     Search Chromatin IP Primers for AXIN2
     RT2 qPCR Primer Assay in human, mouse, rat AXIN2
     GNC Network for AXIN2
     SABiosciences PCR Arrays including human, mouse, rat AXIN2
     Search Tocris compounds for AXIN2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AXIN2 antibodies
     AXIN2 proteins
     AXIN2 lysates
     Antibodies for AXIN2
     See all of Abcam's Antibodies, Kits and Proteins for AXIN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for AXIN2
     Antibodies for AXIN2
     ELISAs for AXIN2
     CLIAs for AXIN2
     Search LifeMap BioReagents cell lines for AXIN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXIN2
     SwitchGear 3'UTR luciferase reporter plasmids for AXIN2
     SwitchGear Promoter luciferase reporter plasmids for AXIN2
     ThermoFisher Antibody for AXIN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXIN2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AXIN2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AXIN2
    Customized:
     lentivirus for stable overexpression of AXIN2
     lentivirus expression plasmids for stable overexpression of AXIN2
     adenovirus for overexpression of AXIN2
     LSBio Antibodies in human, mouse, rat for AXIN2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AXIN2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4