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Aliases for AXIN2 Gene

Aliases for AXIN2 Gene

  • Axin 2 2 3
  • Conductin 2 3 4
  • Axis Inhibition Protein 2 3 4
  • Axin-Like Protein 3 4
  • ODCRCS 3 6
  • AXIL 3 4
  • Axin-2 3
  • Axil 2

External Ids for AXIN2 Gene

Previous GeneCards Identifiers for AXIN2 Gene

  • GC17P064858
  • GC17P067924
  • GC17M063942
  • GC17M064074
  • GC17M060956
  • GC17M063524
  • GC17M058916

Summaries for AXIN2 Gene

Entrez Gene Summary for AXIN2 Gene

  • The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for AXIN2 Gene

AXIN2 (Axin 2) is a Protein Coding gene. Diseases associated with AXIN2 include oligodontia-colorectal cancer syndrome and oligodontia - cancer predisposition syndrome. Among its related pathways are Pathways in cancer and Neural Crest Differentiation. GO annotations related to this gene include protein kinase binding and enzyme binding. An important paralog of this gene is AXIN1.

UniProtKB/Swiss-Prot for AXIN2 Gene

  • Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

Gene Wiki entry for AXIN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AXIN2 Gene

Genomics for AXIN2 Gene

Regulatory Elements for AXIN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AXIN2 Gene

65,528,563 bp from pter
65,561,648 bp from pter
33,086 bases
Minus strand

Genomic View for AXIN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AXIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AXIN2 Gene

Proteins for AXIN2 Gene

  • Protein details for AXIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3MJ88
    • Q9H3M6
    • Q9UH84

    Protein attributes for AXIN2 Gene

    843 amino acids
    Molecular mass:
    93558 Da
    Quaternary structure:
    • Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

neXtProt entry for AXIN2 Gene

Proteomics data for AXIN2 Gene at MOPED

Post-translational modifications for AXIN2 Gene

  • ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
  • Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
  • Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AXIN2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AXIN2 (axin 2)

No data available for DME Specific Peptides for AXIN2 Gene

Domains for AXIN2 Gene

Suggested Antigen Peptide Sequences for AXIN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2T1
  • The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.
  • Contains 1 DIX domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with AXIN2: view

No data available for Gene Families for AXIN2 Gene

Function for AXIN2 Gene

Molecular function for AXIN2 Gene

GENATLAS Biochemistry:
axin 2,murine conduction homolog,negative regulator of the Wnt signaling pathway,promoting the GSK3B dependent phosphorylation of beta catenin (CTNNB1) strong candidate in multiple tumor types
UniProtKB/Swiss-Prot Function:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).

Gene Ontology (GO) - Molecular Function for AXIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 10698523
GO:0008013 beta-catenin binding NAS 11017067
GO:0019899 enzyme binding IPI 19759537
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with AXIN2: view
genes like me logo Genes that share phenotypes with AXIN2: view

miRNA for AXIN2 Gene

miRTarBase miRNAs that target AXIN2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AXIN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AXIN2 Gene

Localization for AXIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AXIN2 Gene


Subcellular locations from

Jensen Localization Image for AXIN2 Gene COMPARTMENTS Subcellular localization image for AXIN2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for AXIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12072559
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with AXIN2: view

Pathways for AXIN2 Gene

genes like me logo Genes that share pathways with AXIN2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for AXIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis --
GO:0001934 positive regulation of protein phosphorylation IMP 20300119
GO:0001957 intramembranous ossification IBA --
GO:0003139 secondary heart field specification IEA --
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA --
genes like me logo Genes that share ontologies with AXIN2: view

Compounds for AXIN2 Gene

(5) Novoseek inferred chemical compound relationships for AXIN2 Gene

Compound -log(P) Hits PubMed IDs
pidotimod 85.2 7
samp 82.3 2
glycogen 50.4 4
threonine 22.7 3
serine 6.95 3
genes like me logo Genes that share compounds with AXIN2: view

Transcripts for AXIN2 Gene

Unigene Clusters for AXIN2 Gene

Axin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AXIN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AXIN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP4: -

Relevant External Links for AXIN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AXIN2 Gene

mRNA expression in normal human tissues for AXIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for AXIN2 Gene

This gene is overexpressed in Pancreatic juice (64.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AXIN2 Gene

SOURCE GeneReport for Unigene cluster for AXIN2 Gene Hs.156527

mRNA Expression by UniProt/SwissProt for AXIN2 Gene

Tissue specificity: Expressed in brain and lymphoblast
genes like me logo Genes that share expressions with AXIN2: view

Expression partners for AXIN2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AXIN2 Gene

Orthologs for AXIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AXIN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AXIN2 35
  • 80.55 (n)
  • 81.38 (a)
AXIN2 36
  • 81 (a)
(Canis familiaris)
Mammalia AXIN2 35
  • 90.75 (n)
  • 93.12 (a)
AXIN2 36
  • 93 (a)
(Mus musculus)
Mammalia Axin2 35
  • 86.2 (n)
  • 90.57 (a)
Axin2 16
Axin2 36
  • 90 (a)
(Pan troglodytes)
Mammalia AXIN2 35
  • 99.45 (n)
  • 99.64 (a)
AXIN2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Axin2 35
  • 86.28 (n)
  • 90.69 (a)
(Monodelphis domestica)
Mammalia AXIN2 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia AXIN2 36
  • 78 (a)
(Gallus gallus)
Aves AXIN2 35
  • 77.01 (n)
  • 81.33 (a)
AXIN2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia AXIN2 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5833 35
(Danio rerio)
Actinopterygii -- 35
axin2 35
  • 65.87 (n)
  • 68.14 (a)
axin2 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Axn 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for AXIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AXIN2 Gene

Gene Tree for AXIN2 (if available)
Gene Tree for AXIN2 (if available)

Paralogs for AXIN2 Gene

Paralogs for AXIN2 Gene

Selected SIMAP similar genes for AXIN2 Gene using alignment to 7 proteins: Pseudogenes for AXIN2 Gene

genes like me logo Genes that share paralogs with AXIN2: view

Variants for AXIN2 Gene

Sequence variations from dbSNP and Humsavar for AXIN2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7591 -- 65,528,964(+) CGAAC(A/T)TCAAA utr-variant-3-prime
rs1133683 -- 65,537,650(-) AGCCC(C/T)CGCTC reference, synonymous-codon
rs2240307 -- 65,558,189(+) GAGAC(A/G)ATGCT synonymous-codon, reference
rs3923086 -- 65,553,370(-) GTGTT(G/T)GAATG intron-variant
rs3923087 -- 65,553,143(-) GTTCA(A/G)CATGG intron-variant

Relevant External Links for AXIN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AXIN2 Gene

Disorders for AXIN2 Gene

(2) OMIM Diseases for AXIN2 Gene (604025)


  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:11017067}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. {ECO:0000269 PubMed:15042511}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for AXIN2 Gene

(14) Novoseek inferred disease relationships for AXIN2 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 86 5
polyposis 57.5 1
colorectal cancer 56.5 7
colon cancer 53.7 4
hepatoblastoma 44 2

Relevant External Links for AXIN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AXIN2: view

No data available for Genatlas for AXIN2 Gene

Publications for AXIN2 Gene

  1. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. (PMID: 10049590) Mai M. … Liu W. (Genomics 1999) 2 3 4 23
  2. Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. (PMID: 16432638) Mostowska A. … Jagodzinski P.P. (J. Hum. Genet. 2006) 3 23 48
  3. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. (PMID: 18708403) Wang X. … Couch F.J. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 23 48
  4. Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. (PMID: 16820935) Kanzaki H. … Shimizu K. (Int. J. Mol. Med. 2006) 3 4 48
  5. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (PMID: 15042511) Lammi L. … Nieminen P. (Am. J. Hum. Genet. 2004) 3 4

Products for AXIN2 Gene

  • Addgene plasmids for AXIN2

Sources for AXIN2 Gene

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