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AXIN1 Gene

protein-coding GIFtS: 68

GC16M000277

axin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AXIN ^², ³, ⁵
MGC52315 ^²
hAxin ^³

Descriptions
Axis inhibition protein 1 ^², ³
axin 1 ^²
axis inhibitor 1 ^²
fused, mouse, homolog of ^²

External Ids
HGNC: 903¹
Entrez Gene: 8312²
UniProtKB: O15169³
Ensembl: ENSG00000103126⁷

Search outside databases for aliases for AXIN1 gene

Previous GC identifer: GC16M000356

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AXIN1:

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS)

domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis

polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3

beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the

wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce

apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other

proteins, has been resolved. Mutations in this gene have been associated with hepatocellular

carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two

transcript variants encoding distinct isoforms have been identified for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: AXN1_HUMAN, O15169

Function: Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to

inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by

activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the

phosphorylation of beta-catenin and APC by GSK3B. Likely to function as a tumor suppressor.

Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Wild-type axin 1

can induce apoptosis in hepatocellular and colorectal cancer cells. Enhances TGF-beta signaling by

recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7

Gene Wiki entry for AXIN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AXIN1 gene

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

AXIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M000277: (about GC identifiers)

Start:	277,441 bp from pter
End:	342,465 bp from pter
Size:	65,025 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AXN1_HUMAN, O15169 (See protein sequence)

Recommended Name: Axin-1

Size: 862 amino acids; 95635 Da

Subunit: Homodimer (By similarity). Interacts with TP53 and HIPK2. Probably part of a complex

consisting of TP53, HIPK2 and AXIN1. Interacts with glycogen synthase kinase-3 beta (GSK3B) and

beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats

contained in beta-catenin. Ternary complex. Also binds to plakoglobin (gamma-catenin), APC, DVL

and PP2A. Interacts with SMAD6, SMAD7 and RNF111. Interacts with DIXDC1; prevents interaction with

MAP3K1. Interacts with MAP3K4, MDFI and MDFIC. Interacts with ANKRD6. Interacts with AIDA

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1DK8 (3D)

1EMU (3D)

Secondary accessions: Q4TT26 Q4TT27 Q86YA7 Q8WVW6 Q96S28

Alternative splicing: 2 isoforms: O15169-1 O15169-2

Post-translational modifications:

Probably phosphorylated by GSK3B and dephosphorylated by PP2A¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003493.1 NP_851393.1

ENSEMBL proteins:

ENSP00000262320 ENSP00000346935

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant AXIN1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Axin 1)
	Human Recombinant Proteins from Abnova (AXIN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	12072559
GO:0005737	cytoplasm	IDA	12072559
GO:0005829	cytosol	EXP	11955436 12000790 12820959 15327769 16753179
GO:0016328	lateral plasma membrane	IDA	12072559

About this table

Antibodies for AXIN1:

	Invitrogen Antibodies for AXIN1
	Millipore Mono- and Polyclonal Antibodies for the study of AXIN1
	Sigma-Aldrich Antibodies for AXIN1
	R&D Systems Antibodies for AXIN1 (Axin-1)
	Cell Signaling Technology (CST) Antibodies for AXIN1
	Antibodies from Abcam (Axin 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AXIN1)
	Novus Biologicals Antibodies for AXIN1

Assays for AXIN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15169

ProtoNet protein and cluster: O15169

1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: AXN1_HUMAN, O15169

Similarity: Contains 1 DIX domain

Similarity: Contains 1 RGS domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AXIN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AXIN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003502

Applied Biosystems Silencer® siRNAs for AXIN1

Sigma-Aldrich siRNA and siRNA Panels for AXIN1

Sigma-Aldrich shRNA for AXIN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003502
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003502
untagged cDNA clones in CMV expression vector (see all 2): NM_003502

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003502

UniProtKB/Swiss-Prot: AXN1_HUMAN, O15169

Function: Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to

inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by

activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the

phosphorylation of beta-catenin and APC by GSK3B. Likely to function as a tumor suppressor.

Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Wild-type axin 1

can induce apoptosis in hepatocellular and colorectal cancer cells. Enhances TGF-beta signaling by

recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7

Genatlas biochemistry entry for AXIN1:

axin 1,ubiquitously expressed (in mouse),negative regulator of the Wnt signaling pathway,promoting

the GSK3B dependent phosphorylation of beta catenin CTNNB1

15/16 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Axin1) (see all 16 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	growth/size	hearing/vestibular/ear	lethality-prenatal/perinatal	life span-post-weaning/aging
limbs/digits/tail	nervous system	normal	renal/urinary system	respiratory system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	NAS	9230313
GO:0008013	beta-catenin binding	ISS	--
GO:0042301	phosphate binding	ISS	--
GO:0042803	protein homodimerization activity	ISS	--
GO:0046332	SMAD binding	IPI	18593713

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for AXIN1 (Your Favorite Gene powered by Ingenuity) (see all 9 )

Endometrial Cancer Signaling
Ephrin Receptor Signaling
Basal Cell Carcinoma Signaling
Molecular Mechanisms of Cancer
Wnt/&beta

GeneDecks AXIN1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AXIN1

5/23 Interacting proteins for AXIN1 (O15169^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 23 )
Interactant Interaction Details
GeneCard External ID(s)
GSK3B P49841¹^,² EBI-710484, EBI-373586 MINT-7025816 MINT-7025707 MINT-7025684 MINT-4508259 EBI-710484, EBI-373586 MINT-7025816 MINT-7025707 MINT-7025684 MINT-4508259
ANP32A P39687¹^,² EBI-710484, EBI-359234 MINT-64311 EBI-710484, EBI-359234 MINT-64311
CRMP1 Q14194¹^,² EBI-710484, EBI-473101 MINT-64312 EBI-710484, EBI-473101 MINT-64312
SMYD2 Q9NRG4¹ EBI-710484, EBI-1055671
Ctnnb1 Ctnnb1 (xeno) Q02248¹ EBI-710484, EBI-397872
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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptosis IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007309 oocyte axis specification TAS 9230313
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 18593713
GO:0030178 negative regulation of Wnt receptor signaling pathway TAS 9482734
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AXIN1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AXIN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AXIN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003502

Sigma-Aldrich siRNA and siRNA Panels for AXIN1

Sigma-Aldrich shRNA for AXIN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003502 NM_181050

REFSEQ mRNAs for AXIN1 gene (2 alternative transcripts):

NM_003502.2 NM_181050.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003502 NM_181050

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003502
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003502
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003502

Additional cDNA sequence:

AB208876.1 AF009674.1 BC017447.1 BC035872.1 BC044648.1 BX648449.1 CR599188.1

7 DOTS entries:

DT.100814372 DT.101976503 DT.97773274 DT.454035 DT.100718839 DT.311122 DT.95375801

24/139 AceView cDNA sequences (see all 139 ):

AL044979 AL045145 NM_181050 BE018188 BI770541 BQ224891 BC044648 CR599188

NM_003502 BM765977 BQ428141 BC017447 BQ682318 AA355700 AL555682 BE301667

BX389979 AI625483 BF091963 AW273130 BU634202 BQ440991 BU500157 BU855932

highest scoring ESTs for AXIN1:

AF009674 AL526136 BC044648 BQ056686 AA121433 AA122137 AA303032 AA303033 AA338446 AA352281

Unigene Cluster for AXIN1:

Axin 1

Hs.592082 [show with all ESTs]

Unigene Representative Sequence: AB208876

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AXIN1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b
SP1:																							-		-
SP2:
SP3:
SP4:															-		-						-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for AXIN1

2 Ensembl transcripts including schematic representations:

ENST00000262320 ENST00000354866

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AXIN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AXIN1

¹ / ² / ³

3 probe-sets matching AXIN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33319_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF009674	1.00	1.00	1.00	1
212849_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA745954	0.60	1.00	0.82	1
212849_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AXIN1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGATGACACT

SOURCE GeneReport for Unigene cluster: Hs.592082
Expression variation in blood from EXPOLDB for AXIN1
UniProtKB/Swiss-Prot: AXN1_HUMAN, O15169
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AXIN1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AXIN1¹	--	axin 1	85.49(n) 87.43(a)	490099 XM_847228.1 XP_852321.1
chimpanzee (Pan troglodytes)	AXIN1¹	--	axin 1	98.94(n) 99.39(a)	453789 XM_001152990.1 XP_001152990.1
cow (Bos taurus)	AXIN1¹	--	axin 1	84.75(n) 86.18(a)	504357 XM_866610.2 XP_871703.1
rat (Rattus norvegicus)	Axin1¹	--	axin 1	84.06(n) 88.32(a)	79257 NM_024405.1 NP_077381.1
mouse (Mus musculus)	Axin1^{1, 5}	17 (11.80 cM)⁵	axin 1^{1, 5}	83.53(n)¹ 87.53(a)¹	12005¹ NM_009733.1¹ NP_033863.1¹ AA259709⁵ AF009011⁵ (see all 16)

About this table Species with no ortholog for AXIN1

ENSEMBL Gene Tree for AXIN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AXIN1 gene

AXIN2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/507 NCBI SNPs in AXIN1 are shown (see all 507 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 154)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs758033^1,2	A,C,F,H,O	337045(+)	`GTCAAG/TGAACA`	2	--	ut5¹ ese³		8		MN EA NA EU	664
	rs394128^1,2	A,C,F	277872(+)	`CTGCCT/CCACTT`	2	--	ut3¹ ese³		6		EA NA MN NS	336
--	rs7198290^1,2	A,C	343498(+)	`TGGTCA/GGCAGG`	2	--	ng3¹		0	--	--	--	--
--	rs2859342^1,2	C	343129(+)	`CATGGC/GCGGGA`	2	--	ng3¹		0	--	--	--	--
	rs2859341^1,2	C	343112(+)	`ATGGGC/GCGGGG`	2	--	ng3¹		0	--	--	--	--
	rs2859340^1,2	C	343098(+)	`ACGAGG/TTGAGA`	2	--	ng3¹		0	--	--	--	--
	rs395545^1,2	C	277751(-)	`TCTGGC/GTGGGG`	2	--	ut3¹		2		NS	74
--	rs45551435^1,2	F	278074(+)	`ACACCC/TGTGCC`	2	--	ut3¹		2		NS	94
--	rs45603234^1,2	F	277821(+)	`GGTGCC/TGGGGG`	2	--	ut3¹		2		NS	92
	rs1805105^1,2	A,C,F,H,O	336265(-)	`ATGGAC/TGAGGA`	2	D/D	syn¹ ese³		4		EU EA WA	412

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HapMap Linkage Disequilibrium images for AXIN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603816 disorders: 114550 607864

UniProtKB/Swiss-Prot: AXN1_HUMAN, O15169

Defects in AXIN1 are involved in hepatocellular carcinoma (HCC) [MIM:114550]

Hypermethylation of the AXIN1 promoter may be associated with caudal duplication anomaly

[MIM:607864]. Caudal duplication anomaly is characterized by the occurrence of duplications of

different organs in the caudal region

10/13 Novoseek disease relationships for AXIN1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
caudal duplication anomaly	93.99	2	16773576 (2)
familial adenomatous polyposis	68.79	3	14970870 (1), 15520370 (1), 15488029 (1)
medulloblastoma	61.72	7	12555076 (3), 11585731 (1), 12209999 (1)
colon cancer	50.01	4	9601641 (1), 11526492 (1), 17143297 (1), 11691783 (1)
hepatocellular carcinoma	43.61	4	11526492 (1), 18592156 (1), 10700176 (1)
colorectal cancer	38.88	5	14566817 (2), 17534895 (1), 10700176 (1)
cancer	31.83	6	15735151 (1), 11170292 (1), 16465433 (1), 10700176 (1) (see all 5)
tumors	30.63	6	16867867 (2), 16773180 (1), 11719457 (1), 12439747 (1) (see all 5)
cervical cancer	8.88	2	12883680 (2)
carcinoma squamous cell	6.49	1	18497987 (1)

About this table

Human Gene Mutation Database: AXIN1
Genetic Association Database: AXIN1
Human Genome Epidemiology Navigator: AXIN1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/125 PubMed articles for AXIN1 gene (see all 125 ):

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. (PubMed id 9230313)^{2, 3, 4} Zeng L.... Costantini F. (1997)
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. (PubMed id 10700176)^{1, 3, 4} Satoh S.... Nakamura Y. (2000)
Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. (PubMed id 16773576)^{1, 3, 4} Oates N.A.... Chong S. (2006)
Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. (PubMed id 15520370)^{1, 3, 6} Fearnhead N.S....Bodmer W.F. (2004)
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. (PubMed id 16601693)^{3, 4} Liu W.... Lin S.-C. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{3, 4} Martin J.... Pennacchio L.A. (2004)
The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PubMed id 15262978)^{3, 4} Wong C.K.... Lin S.-C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. (PubMed id 12192039)^{3, 4} Kusano S. and Raab-Traub N. (2002)
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. (PubMed id 12101426)^{3, 4} Taniguchi K.... Liu W. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8312	HGNC: 903	AceView: AXIN1	Ensembl:ENSG00000103126	euGenes: HUgn8312
ECgene: AXIN1	H-InvDB: AXIN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AXIN1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for AXIN1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AXIN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AXIN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AXIN1		Antibodies for AXIN1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AXIN1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AXIN1)
	Antibodies (AXIN1)
	Chimera RNAi (AXIN1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for AXIN1

	Recombinant Proteins (Axin 1)
	Antibodies (Axin 1)

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Antibodies for AXIN1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AXIN1 Gene at Home site.
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AXIN1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for AXIN1

Summaries
for AXIN1

Genomic Location
for AXIN1

Proteins
for AXIN1

Protein Domains/
Families
for AXIN1

Gene Function
for AXIN1

Pathways & Interactions
for AXIN1

Drugs & Compounds
for AXIN1

Transcripts
for AXIN1

Expression
for AXIN1

Orthologs
for AXIN1

Paralogs
for AXIN1

SNPs/Variants
for AXIN1

Disorders & Mutations
for AXIN1

Medical News
for AXIN1

Publications
for AXIN1

Search for AXIN1

Genome Databases showing AXIN1

Other Databases showing AXIN1

Specialized Databases showing AXIN1

Licensable Technologies
for AXIN1

Services
for AXIN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AXIN1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor AXIN1

Summariesfor AXIN1

Genomic Locationfor AXIN1

Proteinsfor AXIN1

Protein Domains/Familiesfor AXIN1

Gene Functionfor AXIN1

Pathways & Interactionsfor AXIN1

Drugs & Compoundsfor AXIN1

Transcriptsfor AXIN1

Expression for AXIN1

Orthologsfor AXIN1

Paralogsfor AXIN1

SNPs/Variantsfor AXIN1

Disorders & Mutationsfor AXIN1

Medical Newsfor AXIN1

Publicationsfor AXIN1

Search for AXIN1

Genome Databases showing AXIN1

Other Databases showing AXIN1

Specialized Databases showing AXIN1

Licensable Technologiesfor AXIN1

Servicesfor AXIN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AXIN1

Summaries
for AXIN1

Genomic Location
for AXIN1

Proteins
for AXIN1

Protein Domains/
Families
for AXIN1

Gene Function
for AXIN1

Pathways & Interactions
for AXIN1

Drugs & Compounds
for AXIN1

Transcripts
for AXIN1

Expression
for AXIN1

Orthologs
for AXIN1

Paralogs
for AXIN1

SNPs/Variants
for AXIN1

Disorders & Mutations
for AXIN1

Medical News
for AXIN1

Publications
for AXIN1

Licensable Technologies
for AXIN1

Services
for AXIN1