AXDND1 Gene
protein-coding GIFtS: 39
GCID: GC01P179335
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axonemal dynein light chain domain containing 1(Previous name: chromosome 1 open reading frame 125 )
(Previous symbol: C1orf125)
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Aliases
for AXDND1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Axonemal Dynein Light Chain Domain Containing 11 2 | | C1orf1251 2 3 | | FLJ329401 | | Chromosome 1 Open Reading Frame 1251 | | RP11-215I23.22 | | Axonemal Dynein Light Chain Domain-Containing Protein 12 |
Export aliases for AXDND1 gene to outside databases |
Summaries
for AXDND1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for AXDND1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AXDND1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AXDND1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AXDND1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.2 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q25.2AXDND1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P179335: view genomic region
(about GC identifiers)
Start:
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179,334,855 bp from pter |
End:
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179,523,870 bp from pter |
Size:
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189,016 bases |
Orientation:
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plus strand |
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Proteins
for AXDND1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AXDN1_HUMAN, Q5T1B0 (See
protein sequence)Recommended Name: Axonemal dynein light chain domain-containing protein 1 Size: 1012 amino acids; 118027 Da
Sequence caution: Sequence=CAH10571.1; Type=Frameshift; Positions=655;
Secondary accessions: Q6AWB2 Q96LJ3 Q96M01Alternative splicing: 3 isoforms: Q5T1B0-1 Q5T1B0-2 Q5T1B0-3 Explore the universe of human proteins at neXtProt for AXDND1: NX_Q5T1B0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T1B0
AXDND1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653297.3
ENSEMBL proteins: ENSP00000425019 ENSP00000356590 ENSP00000427142 ENSP00000422992 ENSP00000424337 ENSP00000425198 ENSP00000424373 ENSP00000391716 ENSP00000416712
Human Recombinant Protein Products:
AXDND1 Antibody Products:
Assay Products for AXDND1: |
Protein
Domains /
Families
for AXDND1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AXDND1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T1B0ProtoNet protein and cluster: Q5T1B0 |
Function
for AXDND1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AXDND1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AXDND1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AXDND1 (NM_144696) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AXDND1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXDND1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXDND1 |
|
Pathways & Interactions
for AXDND1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AXDND1
|
Drugs & Compounds
for AXDND1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AXDND1
Search CenterWatch for drugs/clinical trials and news about AXDND1 / AXDN1
|
Transcripts
for AXDND1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AXDND1 gene (2 alternative transcripts): NM_182766.2 NM_144696.5 Unigene Cluster for AXDND1: Axonemal dynein light chain domain containing 1 Hs.658505 [show with all ESTs]Unigene Representative Sequence: BX64793514 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509175 ENST00000367618(uc001gmo.3 uc021pfj.1) ENST00000507383
ENST00000508229 ENST00000508285 ENST00000511889 ENST00000510593 ENST00000511157(uc009wxg.3 uc009wxh.3)
ENST00000461179 ENST00000434088 ENST00000484883 ENST00000484455 ENST00000489080(uc001gmr.3)
ENST00000457238(uc001gmn.2 uc010pnl.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AXDND1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AXDND1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AXDND1 (NM_144696) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AXDND1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXDND1 |
Additional cDNA sequence: AK058167.1 AK302972.1 AL833914.1 BC146823.1 BX647935.1 NR_073544.1 12 DOTS entries: DT.100659451 DT.101979466 DT.95305999 DT.95230437 DT.121446580 DT.95086529 DT.121446605 DT.209681 DT.70101401 DT.86675012 DT.95322140 DT.121446531 24/26 AceView cDNA sequences (see all 26): BX647935 AK058167 AW663973 NM_144696 NM_182766 AK057502 AA393293 AW835459 BX506303 AA398634 AI688134 BU568958 AL833914 BI520346 AK093460 BI831348 BI520711 BP371239 AI015507 AA621738 AA770258 AI243879 AA776793 AA725831
GeneLoc Exon Structure
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Expression
for AXDND1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AXDND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCACCCA
About this image
See AXDND1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AXDND1
SOURCE GeneReport for Unigene cluster: Hs.658505
SABiosciences Custom PCR Arrays for AXDND1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AXDND1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AXDND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AXDND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AXDND1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXDND1 |
Orthologs
for AXDND1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for AXDND1 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for AXDND1 (if available)
TreeFam Gene Tree for AXDND1 (if available) |
Paralogs
for AXDND1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for AXDND1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for AXDND1 (179334855 - 179523870 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AXDND1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AXDND1 |
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Disorders
/ Diseases
for AXDND1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AXDND1 for disorders About GeneDecksing
3  diseases for AXDND1: About MalaCardsessential hypertension multiple sclerosis hypertension
Export disorders for AXDND1 gene to outside databases
|
Publications
for AXDND1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AXDND1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AXDND1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)1 Baranzini S.E....Oksenberg J.R. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for AXDND1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing AXDND1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AXDND1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AXDND1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AXDND1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for AXDND1 gene:
Search GeneIP for patents involving AXDND1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AXDND1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AXDND1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AXDND1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AXDND1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AXDND1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AXDND1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AXDND1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AXDND1 | | OriGene Custom Protein Services for AXDND1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AXDND1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AXDND1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AXDND1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AXDND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AXDND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AXDND1 |
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 |  |  |  | |
| | | | Search Tocris compounds for AXDND1 |
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 | | | AXDND1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AXDND1 |
|  |  |  | | | | ThermoFisher Antibodies for AXDND1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AXDND1 |
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