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Aliases for AWAT2 Gene

Aliases for AWAT2 Gene

  • Acyl-CoA Wax Alcohol Acyltransferase 2 2 3
  • Multifunctional O-Acyltransferase 2 3 4
  • Diacylglycerol O-Acyltransferase 2-Like Protein 4 3 4
  • Diacylglycerol O-Acyltransferase Candidate 4 3 4
  • Long-Chain-Alcohol O-Fatty-Acyltransferase 2 3 4
  • Acyl-CoA Retinol O-Fatty-Acyltransferase 3 4
  • Retinol O-Fatty-Acyltransferase 3 4
  • DGAT2L4 3 4
  • ARAT 3 4
  • MFAT 3 4
  • DC4 3 4
  • WS 3 4
  • Diacylglycerol O-Acyltransferase 2-Like 4 2
  • Wax Synthase 4
  • EC 2.3.1.75 4
  • EC 2.3.1.76 4
  • HDC4 4
  • HWS 4

External Ids for AWAT2 Gene

Previous Symbols for AWAT2 Gene

  • DGAT2L4

Summaries for AWAT2 Gene

Entrez Gene Summary for AWAT2 Gene

  • This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

GeneCards Summary for AWAT2 Gene

AWAT2 (Acyl-CoA Wax Alcohol Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Vitamin A and carotenoid metabolism and Vitamin digestion and absorption. GO annotations related to this gene include retinol O-fatty-acyltransferase activity and long-chain-alcohol O-fatty-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for AWAT2 Gene

  • Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AWAT2 Gene

Genomics for AWAT2 Gene

Genomic Location for AWAT2 Gene

Start:
70,040,542 bp from pter
End:
70,049,938 bp from pter
Size:
9,397 bases
Orientation:
Minus strand

Genomic View for AWAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AWAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AWAT2 Gene

Regulatory Elements for AWAT2 Gene

Proteins for AWAT2 Gene

  • Protein details for AWAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6E213-AWAT2_HUMAN
    Recommended name:
    Acyl-CoA wax alcohol acyltransferase 2
    Protein Accession:
    Q6E213
    Secondary Accessions:
    • Q6IEE3
    • Q6P437

    Protein attributes for AWAT2 Gene

    Size:
    333 amino acids
    Molecular mass:
    38094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AWAT2 Gene

Proteomics data for AWAT2 Gene at MOPED

Post-translational modifications for AWAT2 Gene

No Post-translational modifications

Other Protein References for AWAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AWAT2 Gene

Domains for AWAT2 Gene

Protein Domains for AWAT2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AWAT2_HUMAN
Family:
  • Belongs to the diacylglycerol acyltransferase family.:
    • Q6E213
genes like me logo Genes that share domains with AWAT2: view

No data available for Gene Families for AWAT2 Gene

Function for AWAT2 Gene

Molecular function for AWAT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: Vmax=1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate {ECO:0000269 PubMed:15671038};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester.
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + retinol = CoA + retinyl ester.
UniProtKB/Swiss-Prot Function: Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.

Enzyme Numbers (IUBMB) for AWAT2 Gene

Gene Ontology (GO) - Molecular Function for AWAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity IEA --
GO:0050252 retinol O-fatty-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with AWAT2: view

Phenotypes for AWAT2 Gene

GenomeRNAi human phenotypes for AWAT2:
genes like me logo Genes that share phenotypes with AWAT2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AWAT2 Gene

Localization for AWAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AWAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for AWAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AWAT2: view

Pathways for AWAT2 Gene

genes like me logo Genes that share pathways with AWAT2: view

Pathways by source for AWAT2 Gene

1 BioSystems pathway for AWAT2 Gene
2 KEGG pathways for AWAT2 Gene

Interacting Proteins for AWAT2 Gene

Gene Ontology (GO) - Biological Process for AWAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010025 wax biosynthetic process IEA --
GO:0042572 retinol metabolic process IEA --
genes like me logo Genes that share ontologies with AWAT2: view

Compounds for AWAT2 Gene

(894) HMDB Compounds for AWAT2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AWAT2: view

Transcripts for AWAT2 Gene

mRNA/cDNA for AWAT2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AWAT2 Gene

Acyl-CoA wax alcohol acyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AWAT2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for AWAT2 Gene

GeneLoc Exon Structure for
AWAT2
ECgene alternative splicing isoforms for
AWAT2

Expression for AWAT2 Gene

mRNA expression in normal human tissues for AWAT2 Gene

mRNA differential expression in normal tissues according to GTEx for AWAT2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (32.0) and Skin - Sun Exposed (Lower leg) (16.4).

SOURCE GeneReport for Unigene cluster for AWAT2 Gene Hs.661507

mRNA Expression by UniProt/SwissProt for AWAT2 Gene

Q6E213-AWAT2_HUMAN
Tissue specificity: Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas.
genes like me logo Genes that share expressions with AWAT2: view

Orthologs for AWAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AWAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AWAT2 36
  • 99.9 (n)
  • 99.7 (a)
AWAT2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AWAT2 36
  • 84.74 (n)
  • 79.82 (a)
AWAT2 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AWAT2 36
  • 86.69 (n)
  • 84.38 (a)
AWAT2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Awat2 36
  • 85.99 (n)
  • 84.38 (a)
Awat2 16
Awat2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AWAT2 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Awat2 36
  • 84.38 (n)
  • 80.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 37
  • 28 (a)
ManyToMany
CG1942 37
  • 29 (a)
ManyToMany
CG1946 37
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgat-2 37
  • 33 (a)
ManyToMany
dgtr-1 37
  • 33 (a)
ManyToMany
K07B1.4 37
  • 32 (a)
ManyToMany
Y53G8B.2 37
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for AWAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AWAT2 Gene

ENSEMBL:
Gene Tree for AWAT2 (if available)
TreeFam:
Gene Tree for AWAT2 (if available)

Paralogs for AWAT2 Gene

Paralogs for AWAT2 Gene

Selected SIMAP similar genes for AWAT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AWAT2: view

Variants for AWAT2 Gene

Sequence variations from dbSNP and Humsavar for AWAT2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1409993 -- 70,046,362(+) TCACT(A/G)TGAAA intron-variant
rs1409994 -- 70,049,389(+) TAAAT(G/T)GTCGA intron-variant
rs1409995 -- 70,049,445(+) CAACT(A/G)TCTCT intron-variant
rs2281932 -- 70,041,086(+) TATTT(C/T)GGGCG utr-variant-3-prime
rs2281933 -- 70,041,968(+) CTGCC(A/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AWAT2 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv6949 CNV Insertion 18451855

Relevant External Links for AWAT2 Gene

HapMap Linkage Disequilibrium report
AWAT2
Locus Specific Mutation Databases (LSDB)
AWAT2

Disorders for AWAT2 Gene

No disorders were found for AWAT2 Gene.

No data available for UniProtKB/Swiss-Prot for AWAT2 Gene

Publications for AWAT2 Gene

  1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3 4
  2. Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PMID: 15671038) Turkish A.R. … Sturley S.L. (J. Biol. Chem. 2005) 2 3 4
  3. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. (PMID: 16106050) Yen C.-L.E. … Farese R.V. Jr. (J. Lipid Res. 2005) 2 3 4
  4. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PMID: 15220349) Cheng J.B. … Russell D.W. (J. Biol. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AWAT2 Gene

Sources for AWAT2 Gene

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