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Aliases for AWAT1 Gene

Aliases for AWAT1 Gene

  • Acyl-CoA Wax Alcohol Acyltransferase 1 2 3 5
  • Diacylglycerol O-Acyltransferase 2-Like Protein 3 3 4
  • Long-Chain-Alcohol O-Fatty-Acyltransferase 1 3 4
  • Diacylglycerol O-Acyltransferase 2-Like 3 2 3
  • Diacylglycerol Acyltransferase 2 3 4
  • DGAT2L3 3 4
  • DGA2 3 4
  • Diacyl-Glycerol Acyltransferase 2 3
  • EC 2.3.1.75 4

External Ids for AWAT1 Gene

Previous HGNC Symbols for AWAT1 Gene

  • DGAT2L3

Previous GeneCards Identifiers for AWAT1 Gene

  • GC0XP069372
  • GC0XP069455
  • GC0XP063275

Summaries for AWAT1 Gene

Entrez Gene Summary for AWAT1 Gene

  • The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]

GeneCards Summary for AWAT1 Gene

AWAT1 (Acyl-CoA Wax Alcohol Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and long-chain-alcohol O-fatty-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for AWAT1 Gene

  • Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AWAT1 Gene

Genomics for AWAT1 Gene

Regulatory Elements for AWAT1 Gene

Genomic Location for AWAT1 Gene

Chromosome:
X
Start:
70,234,655 bp from pter
End:
70,240,661 bp from pter
Size:
6,007 bases
Orientation:
Plus strand

Genomic View for AWAT1 Gene

Genes around AWAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AWAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AWAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AWAT1 Gene

Proteins for AWAT1 Gene

  • Protein details for AWAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58HT5-AWAT1_HUMAN
    Recommended name:
    Acyl-CoA wax alcohol acyltransferase 1
    Protein Accession:
    Q58HT5
    Secondary Accessions:
    • Q5JT21
    • Q6IEE4

    Protein attributes for AWAT1 Gene

    Size:
    328 amino acids
    Molecular mass:
    37759 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AWAT1 Gene

Proteomics data for AWAT1 Gene at MOPED

Post-translational modifications for AWAT1 Gene

No Post-translational modifications

Other Protein References for AWAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AWAT1 Gene

Domains & Families for AWAT1 Gene

Gene Families for AWAT1 Gene

Protein Domains for AWAT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AWAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q58HT5

UniProtKB/Swiss-Prot:

AWAT1_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with AWAT1: view

Function for AWAT1 Gene

Molecular function for AWAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=31.7 pmol/min/mg enzyme with [14C]oleoyl-CoA as substrate {ECO:0000269 PubMed:15671038}; Vmax=113 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate {ECO:0000269 PubMed:15671038};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester.
UniProtKB/Swiss-Prot Function:
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).

Enzyme Numbers (IUBMB) for AWAT1 Gene

genes like me logo Genes that share phenotypes with AWAT1: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AWAT1 Gene

Localization for AWAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AWAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AWAT1 Gene COMPARTMENTS Subcellular localization image for AWAT1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
golgi apparatus 3
peroxisome 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for AWAT1 Gene

Pathways & Interactions for AWAT1 Gene

genes like me logo Genes that share pathways with AWAT1: view

Pathways by source for AWAT1 Gene

Interacting Proteins for AWAT1 Gene

Gene Ontology (GO) - Biological Process for AWAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with AWAT1: view

No data available for SIGNOR curated interactions for AWAT1 Gene

Drugs & Compounds for AWAT1 Gene

(4) Drugs for AWAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved Nutra 413
Dodecanol Experimental Pharma 0
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(44) Additional Compounds for AWAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AWAT1: view

Transcripts for AWAT1 Gene

mRNA/cDNA for AWAT1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AWAT1 Gene

Acyl-CoA wax alcohol acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AWAT1 Gene

No ASD Table

Relevant External Links for AWAT1 Gene

GeneLoc Exon Structure for
AWAT1
ECgene alternative splicing isoforms for
AWAT1

Expression for AWAT1 Gene

mRNA expression in normal human tissues for AWAT1 Gene

mRNA differential expression in normal tissues according to GTEx for AWAT1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x30.7) and Skin - Sun Exposed (Lower leg) (x12.0).

SOURCE GeneReport for Unigene cluster for AWAT1 Gene Hs.407641

mRNA Expression by UniProt/SwissProt for AWAT1 Gene

Q58HT5-AWAT1_HUMAN
Tissue specificity: Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis.
genes like me logo Genes that share expression patterns with AWAT1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for AWAT1 Gene

Orthologs for AWAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AWAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AWAT1 35
  • 88.48 (n)
  • 87.35 (a)
AWAT1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AWAT1 35
  • 90.33 (n)
  • 88.89 (a)
AWAT1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Awat1 35
  • 84.76 (n)
  • 81.71 (a)
Awat1 16
Awat1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AWAT1 35
  • 92.07 (n)
  • 90.03 (a)
AWAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Awat1 35
  • 84.76 (n)
  • 82.01 (a)
oppossum
(Monodelphis domestica)
Mammalia AWAT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1941 36
  • 31 (a)
ManyToMany
CG1942 36
  • 32 (a)
ManyToMany
CG1946 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgat-2 36
  • 34 (a)
ManyToMany
dgtr-1 36
  • 33 (a)
ManyToMany
K07B1.4 36
  • 37 (a)
ManyToMany
Y53G8B.2 36
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for AWAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AWAT1 Gene

ENSEMBL:
Gene Tree for AWAT1 (if available)
TreeFam:
Gene Tree for AWAT1 (if available)

Paralogs for AWAT1 Gene

Paralogs for AWAT1 Gene

(6) SIMAP similar genes for AWAT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AWAT1: view

Variants for AWAT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for AWAT1 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv519741 CNV Gain 19592680
nsv520416 CNV Loss 19592680
nsv527253 CNV Gain 19592680
nsv522033 CNV Gain 19592680

Variation tolerance for AWAT1 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AWAT1 Gene

HapMap Linkage Disequilibrium report
AWAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for AWAT1 Gene

Disorders for AWAT1 Gene

Relevant External Links for AWAT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AWAT1

No disorders were found for AWAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AWAT1 Gene

Publications for AWAT1 Gene

  1. Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PMID: 15671038) Turkish A.R. … Sturley S.L. (J. Biol. Chem. 2005) 2 3 4 67
  2. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3
  3. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). (PMID: 20374941) Holmes R.S. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2010) 23
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  5. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M. … Kramer W. (Proteins 2003) 26

Products for AWAT1 Gene

Sources for AWAT1 Gene

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