Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AWAT1 Gene

Aliases for AWAT1 Gene

  • Acyl-CoA Wax Alcohol Acyltransferase 1 2 3
  • Diacylglycerol O-Acyltransferase 2-Like Protein 3 3 4
  • Long-Chain-Alcohol O-Fatty-Acyltransferase 1 3 4
  • Diacylglycerol O-Acyltransferase 2-Like 3 2 3
  • Diacylglycerol Acyltransferase 2 3 4
  • DGAT2L3 3 4
  • DGA2 3 4
  • Diacyl-Glycerol Acyltransferase 2 3
  • EC 2.3.1.75 4

External Ids for AWAT1 Gene

Previous Symbols for AWAT1 Gene

  • DGAT2L3

Summaries for AWAT1 Gene

Entrez Gene Summary for AWAT1 Gene

  • The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]

GeneCards Summary for AWAT1 Gene

AWAT1 (Acyl-CoA Wax Alcohol Acyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include long-chain-alcohol O-fatty-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for AWAT1 Gene

  • Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AWAT1 Gene

Genomics for AWAT1 Gene

Genomic Location for AWAT1 Gene

Start:
70,234,655 bp from pter
End:
70,240,661 bp from pter
Size:
6,007 bases
Orientation:
Plus strand

Genomic View for AWAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AWAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AWAT1 Gene

Regulatory Elements for AWAT1 Gene

Proteins for AWAT1 Gene

  • Protein details for AWAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58HT5-AWAT1_HUMAN
    Recommended name:
    Acyl-CoA wax alcohol acyltransferase 1
    Protein Accession:
    Q58HT5
    Secondary Accessions:
    • Q5JT21
    • Q6IEE4

    Protein attributes for AWAT1 Gene

    Size:
    328 amino acids
    Molecular mass:
    37759 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AWAT1 Gene

Proteomics data for AWAT1 Gene at MOPED

Post-translational modifications for AWAT1 Gene

No Post-translational modifications

Other Protein References for AWAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AWAT1 Gene

Domains for AWAT1 Gene

Protein Domains for AWAT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AWAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q58HT5

UniProtKB/Swiss-Prot:

AWAT1_HUMAN
Family:
  • Belongs to the diacylglycerol acyltransferase family.:
    • Q58HT5
genes like me logo Genes that share domains with AWAT1: view

No data available for Gene Families for AWAT1 Gene

Function for AWAT1 Gene

Molecular function for AWAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: Vmax=31.7 pmol/min/mg enzyme with [14C]oleoyl-CoA as substrate {ECO:0000269 PubMed:15671038}; Vmax=113 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate {ECO:0000269 PubMed:15671038};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester
UniProtKB/Swiss-Prot Function: Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).

Enzyme Numbers (IUBMB) for AWAT1 Gene

Gene Ontology (GO) - Molecular Function for AWAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with AWAT1: view
genes like me logo Genes that share phenotypes with AWAT1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AWAT1 Gene

Localization for AWAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AWAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AWAT1 Gene COMPARTMENTS Subcellular localization image for AWAT1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AWAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AWAT1: view

Pathways for AWAT1 Gene

SuperPathways for AWAT1 Gene

No Data Available

Interacting Proteins for AWAT1 Gene

Gene Ontology (GO) - Biological Process for AWAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with AWAT1: view

No data available for Pathways by source for AWAT1 Gene

Compounds for AWAT1 Gene

(887) HMDB Compounds for AWAT1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with AWAT1: view

Transcripts for AWAT1 Gene

mRNA/cDNA for AWAT1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AWAT1 Gene

Acyl-CoA wax alcohol acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AWAT1 Gene

No ASD Table

Relevant External Links for AWAT1 Gene

GeneLoc Exon Structure for
AWAT1
ECgene alternative splicing isoforms for
AWAT1

Expression for AWAT1 Gene

mRNA expression in normal human tissues for AWAT1 Gene

mRNA differential expression in normal tissues according to GTEx for AWAT1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (30.7) and Skin - Sun Exposed (Lower leg) (12.0).

SOURCE GeneReport for Unigene cluster for AWAT1 Gene Hs.407641

mRNA Expression by UniProt/SwissProt for AWAT1 Gene

Q58HT5-AWAT1_HUMAN
Tissue specificity: Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis.
genes like me logo Genes that share expressions with AWAT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for AWAT1 Gene

Orthologs for AWAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AWAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AWAT1 35
  • 92.07 (n)
  • 90.03 (a)
AWAT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AWAT1 35
  • 88.48 (n)
  • 87.35 (a)
AWAT1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AWAT1 35
  • 90.33 (n)
  • 88.89 (a)
AWAT1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Awat1 35
  • 84.76 (n)
  • 81.71 (a)
Awat1 16
Awat1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AWAT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Awat1 35
  • 84.76 (n)
  • 82.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 36
  • 31 (a)
ManyToMany
CG1942 36
  • 32 (a)
ManyToMany
CG1946 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgat-2 36
  • 34 (a)
ManyToMany
dgtr-1 36
  • 33 (a)
ManyToMany
K07B1.4 36
  • 37 (a)
ManyToMany
Y53G8B.2 36
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for AWAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for AWAT1 Gene

ENSEMBL:
Gene Tree for AWAT1 (if available)
TreeFam:
Gene Tree for AWAT1 (if available)

Paralogs for AWAT1 Gene

Paralogs for AWAT1 Gene

Selected SIMAP similar genes for AWAT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AWAT1: view

Variants for AWAT1 Gene

Sequence variations from dbSNP and Humsavar for AWAT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1152194 -- 70,240,095(+) GAGGT(C/T)CTAAC intron-variant
rs1152195 -- 70,239,238(+) ACCAG(C/T)AAGGT intron-variant
rs1152196 -- 70,238,897(+) CCTGG(A/C)ACACT intron-variant
rs1152197 -- 70,237,995(+) CCTAC(C/T)GGTTT intron-variant
rs1152198 -- 70,236,582(+) TTAGC(A/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AWAT1 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv519741 CNV Gain 19592680
nsv520416 CNV Loss 19592680
nsv527253 CNV Gain 19592680
nsv522033 CNV Gain 19592680

Relevant External Links for AWAT1 Gene

HapMap Linkage Disequilibrium report
AWAT1
Locus Specific Mutation Databases (LSDB)
AWAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AWAT1 Gene

Disorders for AWAT1 Gene

No disorders were found for AWAT1 Gene.

No data available for UniProtKB/Swiss-Prot for AWAT1 Gene

Publications for AWAT1 Gene

  1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3 4
  2. Identification of two novel human Acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. (PMID: 15671038) Turkish A.R. … Sturley S.L. (J. Biol. Chem. 2005) 2 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M. … Kramer W. (Proteins 2003) 26

Products for AWAT1 Gene

Sources for AWAT1 Gene

Back to Top

Content