Aliases for AWAT1 Gene
External Ids for AWAT1 Gene
Previous HGNC Symbols for AWAT1 Gene
Previous GeneCards Identifiers for AWAT1 Gene
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
GeneCards Summary for AWAT1 Gene
AWAT1 (Acyl-CoA Wax Alcohol Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and long-chain-alcohol O-fatty-acyltransferase activity. An important paralog of this gene is MOGAT2.
UniProtKB/Swiss-Prot for AWAT1 Gene
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).