Aliases for AVPR1B Gene
External Ids for AVPR1B Gene
Previous HGNC Symbols for AVPR1B Gene
Previous GeneCards Identifiers for AVPR1B Gene
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for AVPR1B Gene
AVPR1B (Arginine Vasopressin Receptor 1B) is a Protein Coding gene. Diseases associated with AVPR1B include melancholia and acth-independent macronodular adrenal hyperplasia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein kinase C binding and vasopressin receptor activity. An important paralog of this gene is NPSR1.
UniProtKB/Swiss-Prot for AVPR1B Gene
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.