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Aliases for AVPR1B Gene

Aliases for AVPR1B Gene

  • Arginine Vasopressin Receptor 1B 2 3 5
  • Vasopressin V3 Receptor 3 4
  • AVPR V1b 3 4
  • AVPR V3 3 4
  • AVPR3 3 4
  • V1bR 3 4
  • Antidiuretic Hormone Receptor 1B 3
  • Pituitary Vasopressin Receptor 3 3
  • Antidiuretic Hormone Receptor 1b 4
  • Arginine Vasopressin Receptor 3 3
  • VPR3 4

External Ids for AVPR1B Gene

Previous HGNC Symbols for AVPR1B Gene

  • AVPR3

Previous GeneCards Identifiers for AVPR1B Gene

  • GC01U990014
  • GC01P202767
  • GC01P204390
  • GC01P206223
  • GC01P177157

Summaries for AVPR1B Gene

Entrez Gene Summary for AVPR1B Gene

  • The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for AVPR1B Gene

AVPR1B (Arginine Vasopressin Receptor 1B) is a Protein Coding gene. Diseases associated with AVPR1B include melancholia and acth-independent macronodular adrenal hyperplasia. Among its related pathways are Calcium signaling pathway and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase C binding. An important paralog of this gene is AVPR2.

UniProtKB/Swiss-Prot for AVPR1B Gene

  • Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

Tocris Summary for AVPR1B Gene

  • Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

Gene Wiki entry for AVPR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AVPR1B Gene

Genomics for AVPR1B Gene

Regulatory Elements for AVPR1B Gene

Enhancers for AVPR1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AVPR1B on UCSC Golden Path with GeneCards custom track

Promoters for AVPR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AVPR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for AVPR1B Gene

Chromosome:
1
Start:
206,109,692 bp from pter
End:
206,117,699 bp from pter
Size:
8,008 bases
Orientation:
Minus strand

Genomic View for AVPR1B Gene

Genes around AVPR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AVPR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AVPR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AVPR1B Gene

Proteins for AVPR1B Gene

  • Protein details for AVPR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47901-V1BR_HUMAN
    Recommended name:
    Vasopressin V1b receptor
    Protein Accession:
    P47901
    Secondary Accessions:
    • B0M0J6
    • Q5TZ00

    Protein attributes for AVPR1B Gene

    Size:
    424 amino acids
    Molecular mass:
    46971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AVPR1B Gene

Proteomics data for AVPR1B Gene at MOPED

Post-translational modifications for AVPR1B Gene

  • Glycosylation at Asn 21
  • Modification sites at PhosphoSitePlus

Other Protein References for AVPR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AVPR1B Gene

Domains & Families for AVPR1B Gene

Suggested Antigen Peptide Sequences for AVPR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47901

UniProtKB/Swiss-Prot:

V1BR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with AVPR1B: view

Function for AVPR1B Gene

Molecular function for AVPR1B Gene

GENATLAS Biochemistry:
vasopressin pituitary V3-type,receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
genes like me logo Genes that share phenotypes with AVPR1B: view

Animal Models for AVPR1B Gene

MGI Knock Outs for AVPR1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for AVPR1B

miRNA for AVPR1B Gene

miRTarBase miRNAs that target AVPR1B

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for AVPR1B (V1b Vasopressin R/AVPR1B)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AVPR1B Gene

Localization for AVPR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVPR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AVPR1B Gene COMPARTMENTS Subcellular localization image for AVPR1B gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for AVPR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10858434
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with AVPR1B: view

Pathways & Interactions for AVPR1B Gene

genes like me logo Genes that share pathways with AVPR1B: view

Gene Ontology (GO) - Biological Process for AVPR1B Gene

None

No data available for SIGNOR curated interactions for AVPR1B Gene

Drugs & Compounds for AVPR1B Gene

(49) Drugs for AVPR1B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desmopressin Approved Pharma Full agonist, Agonist, stimulator, Target Synthetic vasopressin analog; V1B and V2 agonist 0
Vasopressin Approved Pharma Full agonist, Agonist, agonist, Target 0
Terlipressin Approved, Investigational Pharma stimulator, Target 48
Oxytocin Approved Pharma Full agonist, Agonist, agonist Involved in uterine contraction and lactation 376
Tolvaptan Approved Pharma Antagonist AVP V2-receptor antagonist 84

(10) Additional Compounds for AVPR1B Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]AVP
Full agonist, Agonist
[<sup>3</sup>H]SSR149415
Antagonist
AVT
Full agonist, Agonist
OPC-31260
Antagonist
SR 121463A
Antagonist

(5) Tocris Compounds for AVPR1B Gene

Compound Action Cas Number
[Arg8]-Vasopressin Antidiuretic hormone 113-79-1
[Lys8]-Vasopressin Antidiuretic hormone 50-57-7
d[Cha4]-AVP Potent and selective human V1B agonist 500170-27-4
d[Leu4,Lys8]-VP Selective V1B agonist 42061-33-6
Desmopressin Synthetic vasopressin analog; V1B and V2 agonist 16679-58-6

(3) ApexBio Compounds for AVPR1B Gene

Compound Action Cas Number
Conivaptan HCl 168626-94-6
Mozavaptan 137975-06-5
Tolvaptan AVP V2-receptor antagonist 150683-30-0
genes like me logo Genes that share compounds with AVPR1B: view

Transcripts for AVPR1B Gene

mRNA/cDNA for AVPR1B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AVPR1B Gene

Arginine vasopressin receptor 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AVPR1B Gene

No ASD Table

Relevant External Links for AVPR1B Gene

GeneLoc Exon Structure for
AVPR1B
ECgene alternative splicing isoforms for
AVPR1B

Expression for AVPR1B Gene

mRNA expression in normal human tissues for AVPR1B Gene

mRNA differential expression in normal tissues according to GTEx for AVPR1B Gene

This gene is overexpressed in Pituitary (x39.3).

SOURCE GeneReport for Unigene cluster for AVPR1B Gene Hs.1372

genes like me logo Genes that share expression patterns with AVPR1B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AVPR1B Gene

Orthologs for AVPR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for AVPR1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AVPR1B 35
  • 85.39 (n)
  • 81.04 (a)
AVPR1B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AVPR1B 35
  • 85.87 (n)
  • 82.62 (a)
AVPR1B 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Avpr1b 35
  • 83.17 (n)
  • 81.67 (a)
Avpr1b 16
Avpr1b 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AVPR1B 35
  • 99.21 (n)
  • 99.06 (a)
AVPR1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909648 35
  • 83.21 (n)
  • 81.95 (a)
oppossum
(Monodelphis domestica)
Mammalia AVPR1B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AVPR1B 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves AVPR1B 35
  • 71.42 (n)
  • 66.58 (a)
AVT2R 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii avpr2l 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6111 37
  • 32 (a)
Species with no ortholog for AVPR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AVPR1B Gene

ENSEMBL:
Gene Tree for AVPR1B (if available)
TreeFam:
Gene Tree for AVPR1B (if available)

Paralogs for AVPR1B Gene

Paralogs for AVPR1B Gene

(4) SIMAP similar genes for AVPR1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AVPR1B: view

Variants for AVPR1B Gene

Sequence variations from dbSNP and Humsavar for AVPR1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35369693 - 206,116,696(-) CGCAA(C/G)CGCTC reference, missense
rs33990840 - 206,116,320(-) ACTTC(A/C/G)GCTTC reference, missense
rs36030374 - 206,116,092(+) GGGTC(A/G)GCAGC reference, missense
rs28632197 - 206,110,373(-) GATGC(A/G/T)CCGGC reference, missense
rs3891058 - 206,116,219(+) TGCCA(A/C/T)GAGAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AVPR1B Gene

Variant ID Type Subtype PubMed ID
nsv832414 CNV Gain 17160897
nsv873118 CNV Loss 21882294
dgv519n71 CNV Loss 21882294
dgv520n71 CNV Gain 21882294

Variation tolerance for AVPR1B Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AVPR1B Gene

HapMap Linkage Disequilibrium report
AVPR1B
Human Gene Mutation Database (HGMD)
AVPR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AVPR1B Gene

Disorders for AVPR1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for AVPR1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melancholia
acth-independent macronodular adrenal hyperplasia
  • acth-independent macronodular adrenal hyperplasia 2
asperger syndrome
  • asperger disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AVPR1B

Genetic Association Database (GAD)
AVPR1B
Human Genome Epidemiology (HuGE) Navigator
AVPR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AVPR1B
genes like me logo Genes that share disorders with AVPR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AVPR1B Gene

Publications for AVPR1B Gene

  1. Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. (PMID: 17909131) Dempster E.L. … Barr C.L. (Arch. Gen. Psychiatry 2007) 3 4 23 48 67
  2. Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors-molecular dynamics study of the activated receptor-vasopressin-G(alpha) systems. (PMID: 16114100) Slusarz M.J. … Ciarkowski J. (J. Pept. Sci. 2006) 23 25 26
  3. The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy. (PMID: 17027167) Young W.S. … Palkovits M. (Neuroscience 2006) 23 25 26
  4. Vasopressin increases GAGA binding activity to the V1b receptor promoter through transactivation of the MAP kinase pathway. (PMID: 16720725) Volpi S. … Aguilera G. (J. Mol. Endocrinol. 2006) 23 25 26
  5. Further neuroendocrine evidence of enhanced vasopressin V3 receptor responses in melancholic depression. (PMID: 14971638) Dinan T.G. … Scott L.V. (Psychol Med 2004) 23 25 26

Products for AVPR1B Gene

Sources for AVPR1B Gene

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