Aliases for AVPR1A Gene
External Ids for AVPR1A Gene
Previous HGNC Symbols for AVPR1A Gene
Previous GeneCards Identifiers for AVPR1A Gene
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
GeneCards Summary for AVPR1A Gene
AVPR1A (Arginine Vasopressin Receptor 1A) is a Protein Coding gene. Diseases associated with AVPR1A include atypical autism and adenomyosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein kinase C binding and vasopressin receptor activity. An important paralog of this gene is AVPR1B.
UniProtKB/Swiss-Prot for AVPR1A Gene
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.