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Aliases for AVPR1A Gene

Aliases for AVPR1A Gene

  • Arginine Vasopressin Receptor 1A 2 3 5
  • Vascular/Hepatic-Type Arginine Vasopressin Receptor 3 4
  • AVPR V1a 3 4
  • AVPR1 3 4
  • V1aR 3 4
  • V1-Vascular Vasopressin Receptor AVPR1A 3
  • SCCL Vasopressin Subtype 1a Receptor 3
  • Antidiuretic Hormone Receptor 1A 3
  • Antidiuretic Hormone Receptor 1a 4
  • V1a Vasopressin Receptor 3
  • Vasopressin V1a Receptor 3

External Ids for AVPR1A Gene

Previous HGNC Symbols for AVPR1A Gene

  • AVPR1

Previous GeneCards Identifiers for AVPR1A Gene

  • GC12P063279
  • GC12P063551
  • GC12M063255
  • GC12M061826
  • GC12M063540
  • GC12M060591

Summaries for AVPR1A Gene

Entrez Gene Summary for AVPR1A Gene

  • The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for AVPR1A Gene

AVPR1A (Arginine Vasopressin Receptor 1A) is a Protein Coding gene. Diseases associated with AVPR1A include Acth-Independent Macronodular Adrenal Hyperplasia and Asperger Syndrome. Among its related pathways are Peptide ligand-binding receptors and Vascular smooth muscle contraction. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase C binding. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for AVPR1A Gene

  • Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Tocris Summary for AVPR1A Gene

  • Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

Gene Wiki entry for AVPR1A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AVPR1A Gene

Genomics for AVPR1A Gene

Regulatory Elements for AVPR1A Gene

Enhancers for AVPR1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G063095 0.7 ENCODE 11 +58.2 58246 1.2 GATAD2A HLF CEBPB MAX CEBPG ZNF384 ZNF644 RARA JUND ATF4 AVPR1A GC12P063091 ENSG00000279444
GH12G062920 0.6 dbSUPER 4.4 +230.8 230806 4.1 PKNOX1 ZNF680 FEZF1 ZNF394 ZNF121 PRDM6 FOS ZNF652 SP7 RNU1-83P AVPR1A PPM1H GC12M062851
GH12G063149 1.1 Ensembl ENCODE 0.7 +2.7 2734 2.5 KLF17 ZNF2 RAD21 YY1 ZNF366 SCRT2 ZNF143 ZNF654 REST CBX8 AVPR1A ENSG00000279444
GH12G063345 0.3 FANTOM5 1.4 -191.3 -191322 0.2 DPY19L2 AVPR1A ENSG00000258117 GC12M063254
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AVPR1A on UCSC Golden Path with GeneCards custom track

Genomic Location for AVPR1A Gene

Chromosome:
12
Start:
63,142,287 bp from pter
End:
63,153,860 bp from pter
Size:
11,574 bases
Orientation:
Minus strand

Genomic View for AVPR1A Gene

Genes around AVPR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AVPR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AVPR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AVPR1A Gene

Proteins for AVPR1A Gene

  • Protein details for AVPR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37288-V1AR_HUMAN
    Recommended name:
    Vasopressin V1a receptor
    Protein Accession:
    P37288

    Protein attributes for AVPR1A Gene

    Size:
    418 amino acids
    Molecular mass:
    46800 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5 flanking region of AVPR1A. One such allelic variant has been linked to autism.

    Three dimensional structures from OCA and Proteopedia for AVPR1A Gene

neXtProt entry for AVPR1A Gene

Post-translational modifications for AVPR1A Gene

  • Glycosylation at posLast=2727 and Asn196
  • Modification sites at PhosphoSitePlus

Other Protein References for AVPR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AVPR1A Gene

Domains & Families for AVPR1A Gene

Suggested Antigen Peptide Sequences for AVPR1A Gene

Graphical View of Domain Structure for InterPro Entry

P37288

UniProtKB/Swiss-Prot:

V1AR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with AVPR1A: view

Function for AVPR1A Gene

Molecular function for AVPR1A Gene

GENATLAS Biochemistry:
vasopressin,vascular,ViA-type receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Gene Ontology (GO) - Molecular Function for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005000 vasopressin receptor activity IBA,IEA --
GO:0005080 protein kinase C binding TAS 10858434
GO:0005515 protein binding IPI 18402937
genes like me logo Genes that share ontologies with AVPR1A: view
genes like me logo Genes that share phenotypes with AVPR1A: view

Animal Models for AVPR1A Gene

MGI Knock Outs for AVPR1A:

Animal Model Products

  • Taconic Biosciences Mouse Models for AVPR1A

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for AVPR1A (V1a Vasopressin R/AVPR1A)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AVPR1A Gene

Localization for AVPR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVPR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AVPR1A gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10858434
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8838314
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AVPR1A: view

Pathways & Interactions for AVPR1A Gene

genes like me logo Genes that share pathways with AVPR1A: view

Gene Ontology (GO) - Biological Process for AVPR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA --
GO:0002125 maternal aggressive behavior IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
GO:0006091 generation of precursor metabolites and energy TAS 8106369
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with AVPR1A: view

No data available for SIGNOR curated interactions for AVPR1A Gene

Drugs & Compounds for AVPR1A Gene

(71) Drugs for AVPR1A Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tolvaptan Approved Pharma Antagonist, antagonist, Target AVP V2-receptor antagonist, Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active 90
Conivaptan Approved, Investigational Pharma Antagonist, antagonist, Target 21
Desmopressin Approved Pharma Full agonist, Agonist, stimulator, Target Hemostatic and anti-diuretic 0
Vasopressin Approved Pharma Full agonist, Agonist, agonist, Target 0
Terlipressin Approved, Investigational Pharma stimulator, Target 55

(11) Additional Compounds for AVPR1A Gene - From: IUPHAR, Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]AVP
Full agonist, Agonist
[<sup>3</sup>H]SR49059
Antagonist
[Phe<sup>2</sup>]OVT
Full agonist, Agonist
AVT
Full agonist, Agonist
OPC-31260
Antagonist

(5) Tocris Compounds for AVPR1A Gene

Compound Action Cas Number
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Selective vasopressin V1A antagonist 73168-24-8
[Arg8]-Vasopressin Antidiuretic hormone 113-79-1
OPC 21268 Orally active vasopressin V1 antagonist 131631-89-5
SR 49059 Selective, orally active vasopressin V1A receptor antagonist 150375-75-0
Tolvaptan Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active 150683-30-0

(9) ApexBio Compounds for AVPR1A Gene

Compound Action Cas Number
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin 73168-24-8
Atosiban mixed antagonist of oxytocin and vasopressin receptors 90779-69-4
Conivaptan HCl 168626-94-6
d[Cha4]-AVP
d[Leu4,Lys8]-VP 42061-33-6
Mozavaptan 137975-06-5
OPC 21268 131631-89-5
SR 49059 150375-75-0
Tolvaptan AVP V2-receptor antagonist 150683-30-0
genes like me logo Genes that share compounds with AVPR1A: view

Drug Products

Transcripts for AVPR1A Gene

mRNA/cDNA for AVPR1A Gene

Unigene Clusters for AVPR1A Gene

Arginine vasopressin receptor 1A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for AVPR1A (V1a Vasopressin R/AVPR1A)

Alternative Splicing Database (ASD) splice patterns (SP) for AVPR1A Gene

No ASD Table

Relevant External Links for AVPR1A Gene

GeneLoc Exon Structure for
AVPR1A
ECgene alternative splicing isoforms for
AVPR1A

Expression for AVPR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AVPR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AVPR1A Gene

This gene is overexpressed in Artery - Tibial (x10.6), Adrenal Gland (x7.8), Liver (x5.7), and Adipose - Visceral (Omentum) (x5.1).

Protein differential expression in normal tissues from HIPED for AVPR1A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AVPR1A Gene



Protein tissue co-expression partners for AVPR1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AVPR1A Gene:

AVPR1A

SOURCE GeneReport for Unigene cluster for AVPR1A Gene:

Hs.2131

Evidence on tissue expression from TISSUES for AVPR1A Gene

  • Liver(4.2)
  • Lung(4)
  • Adrenal gland(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with AVPR1A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AVPR1A Gene

Orthologs for AVPR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for AVPR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AVPR1A 35 34
  • 98.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AVPR1A 35 34
  • 85.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AVPR1A 35 34
  • 84.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Avpr1a 35 16 34
  • 83.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Avpr1a 34
  • 82.93 (n)
oppossum
(Monodelphis domestica)
Mammalia AVPR1A 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AVPR1A 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves AVPR1A 34
  • 75.59 (n)
VT4 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AVPR1A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia avpr1a 34
  • 69.85 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC571591 34
  • 66.67 (n)
AVPR1A (2 of 2) 35
  • 63 (a)
OneToMany
avpr1b 35
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta GRHR 36
  • 31 (a)
CG6111 36
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea F14F4.1 34
  • 43.8 (n)
T07D10.2 36
  • 29 (a)
Species where no ortholog for AVPR1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AVPR1A Gene

ENSEMBL:
Gene Tree for AVPR1A (if available)
TreeFam:
Gene Tree for AVPR1A (if available)

Paralogs for AVPR1A Gene

Paralogs for AVPR1A Gene

(5) SIMAP similar genes for AVPR1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AVPR1A: view

Variants for AVPR1A Gene

Sequence variations from dbSNP and Humsavar for AVPR1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000074731 -- 63,144,923(+) AAATT(G/T)AATTG utr-variant-3-prime
rs1000557231 -- 63,142,998(+) GAAAA(A/C/G)CAGTT utr-variant-3-prime
rs1000588313 -- 63,143,325(+) ATACA(C/T)AAAAC utr-variant-3-prime
rs1001235000 -- 63,149,078(+) GTAGG(C/T)GCAGA intron-variant
rs1001292278 -- 63,148,705(+) TATAT(C/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AVPR1A Gene

Variant ID Type Subtype PubMed ID
esv2761742 CNV loss 21179565
nsv1035231 CNV loss 25217958
nsv1046836 CNV gain 25217958
nsv469592 CNV loss 16826518
nsv832436 CNV gain 17160897

Variation tolerance for AVPR1A Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AVPR1A Gene

Human Gene Mutation Database (HGMD)
AVPR1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AVPR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AVPR1A Gene

Disorders for AVPR1A Gene

MalaCards: The human disease database

(4) MalaCards diseases for AVPR1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acth-independent macronodular adrenal hyperplasia
  • acth-independent macronodular adrenocortical hyperplasia
asperger syndrome
  • asperger disorder
borderline personality disorder
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AVPR1A

Genetic Association Database (GAD)
AVPR1A
Human Genome Epidemiology (HuGE) Navigator
AVPR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AVPR1A
genes like me logo Genes that share disorders with AVPR1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AVPR1A Gene

Publications for AVPR1A Gene

  1. Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. (PMID: 8106369) Thibonnier M. … Clauser E. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. (PMID: 20142561) Masuki S. … Nose H. (Hypertension 2010) 3 22 46 64
  3. Musical aptitude is associated with AVPR1A-haplotypes. (PMID: 19461995) Ukkola L.T. … JAorvelAo I. (PLoS ONE 2009) 3 22 46 64
  4. Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. (PMID: 19195791) Levin R. … Ebstein R.P. (Psychoneuroendocrinology 2009) 3 22 46 64
  5. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck M.E. … Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 22 46 64

Products for AVPR1A Gene

Sources for AVPR1A Gene

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