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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AVPR1A Gene

protein-coding GIFtS: 69
GCID: GC12M063540

arginine vasopressin receptor 1A

(Previous symbol: AVPR1)

Explore 21 diseases affiliated with
AVPR1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Arginine Vasopressin Receptor 1A¹ ²		AVPR V1a² ³
AVPR1¹ ² ³		SCCL Vasopressin Subtype 1a Receptor²
Antidiuretic Hormone Receptor 1a² ³		V1-Vascular Vasopressin Receptor AVPR1A²
Vascular/Hepatic-Type Arginine Vasopressin Receptor² ³		V1a Vasopressin Receptor²
V1aR² ³		Vasopressin V1a Receptor²

External Ids:	HGNC: 895¹	Entrez Gene: 552²	Ensembl: ENSG00000166148⁷	OMIM: 600821⁵	UniProtKB: P37288³

Export aliases for AVPR1A gene to outside databases

Previous GC identifers: GC12P063279 GC12P063551 GC12M063255 GC12M061826 GC12M060591

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AVPR1A:

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of

G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which

stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and

proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: V1AR_HUMAN, P37288

Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a

phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation

and attachment

summary for AVPR1A:

Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis

and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to

oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle

cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found

to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in

the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively

on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for AVPR1A (Arginine vasopressin receptor 1A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AVPR1A gene promoter:
Max1 STAT5B STAT1 AML1a ATF-2 Evi-1 CRE-BP1 COMP1 ATF6 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AVPR1A promoter sequence

Search SABiosciences Chromatin IP Primers for AVPR1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AVPR1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14-q15 Ensembl cytogenetic band: 12q14.2 HGNC cytogenetic band: 12q14-q15

AVPR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVPR1A gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M063540: view genomic region (about GC identifiers)

Start:	63,539,014 bp from pter	End:	63,546,590 bp from pter
Size:	7,577 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: V1AR_HUMAN, P37288 (See protein sequence)

Recommended Name: Vasopressin V1a receptor

Size: 418 amino acids; 46800 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Miscellaneous: Differences in regional receptor expression in the brain as well as differences in social behavior may

result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has

been linked to autism

1 PDB 3D structure from and Proteopedia for AVPR1A:

1YTV (3D)

Explore the universe of human proteins at neXtProt for AVPR1A: NX_P37288

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P37288

AVPR1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000697.1

ENSEMBL proteins:

ENSP00000449822 ENSP00000299178

Reactome Protein details: P37288
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant AVPR1A Protein
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	Uscn Proteins for AVPR1A

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	TAS	10858434
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8838314
GO:0016021	integral to membrane	--	--
GO:0031410	cytoplasmic vesicle	IEA	--

AVPR1A for ontologies About GeneDecksing

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	ThermoFisher Antibodies for AVPR1A

Assay Products for AVPR1A:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript AVPR1A-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AVPR1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AVPR1A for domains About GeneDecksing

5 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR015076 DUF1856

IPR001224 Vprs_V1A_rcpt

IPR000276 GPCR_Rhodpsn

IPR001817 Vasoprsn_rcpt

Graphical View of Domain Structure for InterPro Entry P37288

ProtoNet protein and cluster: P37288

2 Blocks protein families:

IPB001224 Vasopressin V1A receptor signature

IPB001817 Vasopressin receptor signature

UniProtKB/Swiss-Prot: V1AR_HUMAN, P37288

Similarity: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: V1AR_HUMAN, P37288

Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a

phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation

and attachment

Genatlas biochemistry entry for AVPR1A:

vasopressin,vascular,ViA-type receptor,G protein coupled receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone: AVPR1A Browse MicroRNA Expression Plasmids
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		hsa-miR-146a* hsa-miR-4314 hsa-miR-708*
		SwitchGear 3'UTR luciferase reporter plasmid: AVPR1A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AVPR1A (see all 7) OriGene shRNA RFP: AVPR1A OriGene siRNA: AVPR1A
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		Search LifeMap BioReagents cell lines for AVPR1A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVPR1A

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005000	vasopressin receptor activity	IEA	--
GO:0005080	protein kinase C binding	TAS	10858434
GO:0005515	protein binding	IPI	18402937
GO:0017046	peptide hormone binding	IEA	--
GO:0031894	V1A vasopressin receptor binding	IEA	--

AVPR1A for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for AVPR1A:

Decreased substrate adherent c

Increased cell number in G1, s

Animal Models:
Mouse knock-outs for AVPR1A: Avpr1a^tm1Sbhu Avpr1a^tm1Lex Avpr1a^tm1Gzt
10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Avpr1a):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	muscle	nervous system	normal

AVPR1A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
Peptide ligand-binding receptors	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Vasopressin-like receptors

Vasopressin-like receptors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for AVPR1A

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

2 BioSystems Pathways for AVPR1A

	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/9 Reactome Pathways for AVPR1A (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	Vasopressin-like receptors

3 Kegg Pathways (Kegg details for AVPR1A):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction

AVPR1A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for AVPR1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/131 Interacting proteins for AVPR1A (P37288³ ENSP00000299178⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 131)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AVP	P01185³, ENSP00000369647⁴	I2D: score=1 STRING: ENSP00000369647
GRK5	P34947³, ENSP00000376609⁴	I2D: score=2 STRING: ENSP00000376609
PRKCA	P17252³, ENSP00000284384⁴	I2D: score=2 STRING: ENSP00000284384
ADRA1D	ENSP00000368766⁴	STRING: ENSP00000368766
AGTR1	ENSP00000273430⁴	STRING: ENSP00000273430

About this table

Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001992	regulation of systemic arterial blood pressure by vasopressin	IEA	--
GO:0002125	maternal aggressive behavior	IEA	--
GO:0003084	positive regulation of systemic arterial blood pressure	IEA	--
GO:0006091	generation of precursor metabolites and energy	TAS	8106369
GO:0006950	response to stress	--	--

AVPR1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AVPR1A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for AVPR1A available from Tocris Bioscience About this table

Compound	Action	CAS #
OPC 2128	Orally active vasopressin V1 antagonist	[131631-89-5]
[Arg8]-Vasopressin	Antidiuretic hormone	[113-79-1]
SR 49059	Selective, orally active vasopressin V1A receptor antagonist	[150375-75-0]
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin	Selective vasopressin V1A antagonist	[73168-24-8]

2 HMDB Compounds for AVPR1A About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Vasopressin	3-(Phenylalanine)-8-lysine oxytocin (see all 8)	11000-17-2	--

5 DrugBank Compounds for AVPR1A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Conivaptan	Conivaptan hydrochloride (see all 3)	210101-16-9	target	antagonist	19057376 17592003 17202666 20054444 19695403 11752352 17919259 19663609 16522696 17428103
Terlipressin	N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin (see all 4)	14636-12-5	target	stimulator	17275806 16011575 17303660 11752352 16532916 16511036
Vasopressin	3-Isoleucyl vasopressin (see all 8)	11000-17-2	target	--	17275806 17303660 16011575 16511036 16532916
Desmopressin	1-Desamino-8-D-arginine vasopressin (see all 4)	16679-58-6	target	--	10594321 8957254 15613460 10731046
Felypressin	--	56-59-7	target	agonist	18655903 17139284 11752352 17016423

10 Novoseek chemical compound relationships for AVPR1A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovta	90.3	2	15613460 (1)
sr49059	89.9	10	15823830 (2), 16565083 (2), 12869559 (2), 14678081 (1) (see all 6)
atosiban	79.3	2	10519430 (1), 12436949 (1)
arginine	68.7	34	16520824 (2), 19195791 (2), 18655892 (2), 18655900 (2) (see all 20)
acth	42.2	3	12160092 (1), 15642780 (1), 16114100 (1)
calcium	12.8	11	12764111 (3), 15613460 (2), 7969820 (1), 17360584 (1) (see all 5)
prazosin	12.6	1	10486651 (1)
lysine	0	2	9141585 (1)
phosphatidylinositol	0	2	9284404 (1), 8621513 (1)
cysteine	0	2	10544254 (1), 12869559 (1)

Search CenterWatch for drugs/clinical trials and news about AVPR1A / V1AR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AVPR1A gene:

NM_000706.4

Unigene Cluster for AVPR1A:

Arginine vasopressin receptor 1A

Hs.2131 [show with all ESTs]

Unigene Representative Sequence: NM_000706

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000550940 ENST00000299178(uc001sro.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AVPR1A

Additional cDNA sequence:

AF030625.1 AF101725.1 AY322550.1 BC074803.2 BC074804.2 L25615.1 S73899.1

3 DOTS entries:

DT.310927 DT.436381 DT.65285985

24/41 AceView cDNA sequences (see all 41):

BC074804 NM_000706 AI796495 BU072335 AY322550 BX409993 BX452085 BX461255

AW451399 AF101725 AI654158 AF030625 AI521688 AW293471 AL041679 S73899

AW470784 AW612307 BU072761 AI634010 BC074803 CB048700 R72131 BV203119

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AVPR1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGGGGAAT

About this image

AVPR1A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AVPR1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AVPR1A

SOURCE GeneReport for Unigene cluster: Hs.2131

SABiosciences Expression via Pathway-Focused PCR Arrays including AVPR1A:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Hypertension in human mouse rat

Hepatotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVPR1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AVPR1A gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AVPR1A¹	arginine vasopressin receptor 1A	75.43(n) 71.78(a)		771773 NM_001110438.1 NP_001103908.1
lizard (Anolis carolinensis)	Reptilia	D0VFF9_ANOCA⁶	Vasotocin V1a receptor Fragment	73(a)	1 ↔ 1	5(50861929-50862171)
zebrafish (Danio rerio)	Actinopterygii	LOC571591¹	Arg8-vasotocin receptor-like	67.78(n) 64.9(a)		571591 XM_695195.2 XP_700287.2
worm (Caenorhabditis elegans)	Secernentea	T07D10.2³ F14F4.1¹	conopressin receptor like³ Protein F14F4.1¹	29(a)³ 43.8(n)¹ 33.58(a)¹		I(12629224-12631137)³ 184471¹ NM_078076.1¹ NP_510477.1¹

ENSEMBL Gene Tree for AVPR1A (if available)
TreeFam Gene Tree for AVPR1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AVPR1A gene

GPR150² AVPR1B² AVPR2² OXTR² GNRHR² NPSR1² GNRHR2²

5 SIMAP similar genes for AVPR1A using alignment to 2 protein entries: V1AR_HUMAN (see all proteins):

AVPR1 AVPR1B OXTR AVPR2 GNRHR

AVPR1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200514244^1,2		--	63536078(+)	`AAAAG-/AAAAAA`	1	--	int¹		0	--	--	--	--
rs7967970^1,2	C,F,A,H,	--	63536136(+)	`GTCTAC/GTGGGA`	1	--	int¹		5		NS EA WA	526
rs74097647^1,2	C,	--	63536142(+)	`TGGGAA/GAAAAT`	1	--	int¹		2		WA	120
rs7967990^1,2	C,F,A,H,	--	63536241(+)	`AGATGA/TTGTTT`	1	--	int¹		11		NS EA NA WA CSA	658
rs181156019^1,2		--	63536272(+)	`ATGACA/GTCAGC`	1	--	int¹		0	--	--	--	--
rs186467276^1,2		--	63536278(+)	`TCAGCA/TAACCT`	1	--	int¹		0	--	--	--	--
rs74097649^1,2	C,F,	--	63536349(+)	`ACTTAT/CTGAAA`	1	--	int¹		3		WA CSA	122
rs191525715^1,2		--	63536388(+)	`CTATGC/GTCACT`	1	--	int¹		0	--	--	--	--
rs74097651^1,2	C,F,	--	63536565(+)	`TAGAAA/GCAAGA`	1	--	ut3¹		4		WA CSA	124
rs113841722^1,2		--	63536678(+)	`TTTATC/AACTCA`	1	--	ut3¹		1		CSA	2

HapMap Linkage Disequilibrium report for AVPR1A (63539014 - 63546590 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AVPR1A
1 CNV: 2171
Human Gene Mutation Database (HGMD): AVPR1A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AVPR1A for disorders           About GeneDecksing

OMIM gene information: 600821    OMIM disorders: --

20/21 diseases for AVPR1A (see all 21):    About MalaCards

nephrogenic diabetes insipidus diabetes insipidus adrenal hyperplasia autism spectrum disorder

hepatitis anorexia nervosa portal hypertension bipolar disorder

panic disorder small cell carcinoma essential hypertension adenomyosis

hypertension ischemia aldosteronism lung carcinoma

lung cancer carcinoma breast cancer neuronitis

1 disease from the University of Copenhagen DISEASES database for AVPR1A:

Autistic disorder

7 Novoseek disease relationships for AVPR1A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adrenal hyperplasia	69.3	1	12466375 (1)
dysmenorrhea	63.6	5	10826575 (2), 14678081 (1), 16532916 (1), 16706682 (1)
tumors	1.95	1	18427561 (1)
ischemia	0	1	16532916 (1)
cancer lung	0	1	15613460 (1)
bipolar disorder	0	1	16403186 (1)
carcinoma	0	1	8050087 (1)

Genetic Association Database (GAD): AVPR1A
Human Genome Epidemiology (HuGE) Navigator: AVPR1A (27 documents)

Export disorders for AVPR1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AVPR1A gene, integrated from 9 sources (see all 184):
(articles sorted by number of sources associating them with AVPR1A)

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Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. (PubMed id 8106369)^{1, 2, 3, 9} Thibonnier M....Clauser E. (1994)
Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (PubMed id 9581826)^{1, 2, 9} North W.G.... Du J. (1998)
Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. (PubMed id 9357056)^{1, 2, 9} North W.G.... Du J. (1997)
AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. (PubMed id 16205790)^{1, 4, 9} Bachner-Melman R....Ebstein R.P. (2005)
A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein. (PubMed id 16511036)^{2, 7} Adikesavan N.V.... Shoham M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. (PubMed id 12082568)^{1, 2} Kim S.J....Insel T.R. (2002)
Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor. (PubMed id 8074728)^{1, 2} Hirasawa A.... Tsujimoto G. (1994)
Molecular genetic studies of the arginine vasopressin 1a receptor (AVPR1a) and the oxytocin receptor (OXTR) in human behaviour: from autism to altruism with some notes in between. (PubMed id 18655900)^{1, 9} Israel S....Ebstein R.P. (2008)
Association between the arginine vasopressin 1a receptor (AVPR1a) gene and autism in a family-based study: mediation by socialization skills. (PubMed id 16520824)^{1, 9} Yirmiya N....Ebstein R.P. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 552	HGNC: 895	AceView: AVPR1A	Ensembl:ENSG00000166148	euGenes: HUgn552
ECgene: AVPR1A	Kegg: 552	H-InvDB: AVPR1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AVPR1A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AVPR1A gene
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Patent Information for AVPR1A gene:
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arginine vasopressin receptor 1A

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AVPR1A Gene

arginine vasopressin receptor 1A

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