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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AVPI1 Gene

protein-coding GIFtS: 46
GCID: GC10M099427

arginine vasopressin-induced 1

Explore 1 disease affiliated with
AVPI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Arginine Vasopressin-Induced 1¹ ²		AVP-Induced Protein 1² ³
PP5395¹ ²		RP11-548K23.7²
VIP32¹ ²		Arginine Vasopressin-Induced Protein 1²
VIT32¹ ²		Vasopressin-Induced Transcript²

External Ids:	HGNC: 30898¹	Entrez Gene: 60370²	Ensembl: ENSG00000119986⁷	UniProtKB: Q5T686³

Export aliases for AVPI1 gene to outside databases

Previous GC identifers: GC10M099102 GC10M093062

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AVPI1_HUMAN, Q5T686

Function: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling

(By similarity)

Gene Wiki entry for AVPI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AVPI1 gene promoter:
N-Myc MZF-1 CREB Sp1 deltaCREB Olf-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AVPI1 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AVPI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q24.2

AVPI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVPI1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M099427: view genomic region (about GC identifiers)

Start:	99,437,181 bp from pter	End:	99,447,080 bp from pter
Size:	9,900 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AVPI1_HUMAN, Q5T686 (See protein sequence)

Recommended Name: Arginine vasopressin-induced protein 1

Size: 147 amino acids; 16773 Da

Sequence caution: Sequence=AAG44474.1; Type=Frameshift; Positions=28;

Secondary accessions: Q53G32 Q9H2R9 Q9HBN9

Explore the universe of human proteins at neXtProt for AVPI1: NX_Q5T686

AVPI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_068378.2

ENSEMBL proteins:

ENSP00000359660

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AVPI1 for domains About GeneDecksing

1 InterPro domain/family:

IPR020282 Arg_vasopressin-induced_prot_1

Graphical View of Domain Structure for InterPro Entry Q5T686

ProtoNet protein and cluster: Q5T686

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AVPI1_HUMAN, Q5T686

Function: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling

(By similarity)

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AVPI1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for AVPI1 (Q5T686³ ENSP00000359660⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKG	Q9Y6K9³, ENSP00000358622⁴	I2D: score=1 STRING: ENSP00000358622
MDFI	Q99750³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0007049	cell cycle	IEA	--

AVPI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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1 HMDB Compound for AVPI1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Sodium	Sodium (see all 2)	7440-23-5	--

Search CenterWatch for drugs/clinical trials and news about AVPI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AVPI1 gene:

NM_021732.2

Unigene Cluster for AVPI1:

Arginine vasopressin-induced 1

Hs.23918 [show with all ESTs]

Unigene Representative Sequence: BM926282

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000370626(uc001koh.1 uc001koi.2)

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Additional cDNA sequence:

AF131791.1 AF218019.1 AF241786.1 AK024533.1 AK222493.1 AK223099.1 AY505173.1 BC000877.1

6 DOTS entries:

DT.312533 DT.100798119 DT.95291162 DT.100798107 DT.121250791 DT.91983124

24/203 AceView cDNA sequences (see all 203):

BI257315 BQ636519 BI257530 AW014857 BF196513 CR614805 BM713355 AI565946

BM980972 AW662193 CR595926 CD368395 BU739773 AA758381 CR608629 AW081240

AI343259 CB241292 N26801 CR591038 CD367635 AY505173 AI565957 BQ045038

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for AVPI1 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4
SP1:
SP2:					-		-
SP3:

ECgene alternative splicing isoforms for AVPI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AVPI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCCAGCAG

About this image

AVPI1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AVPI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AVPI1

SOURCE GeneReport for Unigene cluster: Hs.23918

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for AVPI1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Avpi1^{1 , 5}	arginine vasopressin-induced 1^{1, 5}	80(n)¹ 78.57(a)¹		19 (35.80 cM)⁵ 69534¹ NM_027106.4¹ NP_081382.1¹ 42123273⁵
lizard (Anolis carolinensis)	Reptilia	AVPI1⁶	--	36(a)	1 ↔ 1	3(39175610-39178298)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-197k17.3⁶	si:ch211-197k17.3	23(a)	1 ↔ 1	1(55297985-55304672)

ENSEMBL Gene Tree for AVPI1 (if available)
TreeFam Gene Tree for AVPI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AVPI1 for disorders About GeneDecksing

1 disease for AVPI1: About MalaCards

alzheimer's disease

Human Genome Epidemiology (HuGE) Navigator: AVPI1 (1 document)

Export disorders for AVPI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AVPI1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with AVPI1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 3} Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)^{1, 3} Andersson B.... Gibbs R.A. (1996)
A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation. (PubMed id 12356727)^{1, 9} Nicod M....Firsov D. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)¹ Fenner B.J....Prehn J.H. (2010)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 60370	HGNC: 30898	AceView: AVPI1	Ensembl:ENSG00000119986	euGenes: HUgn60370
ECgene: AVPI1	H-InvDB: AVPI1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AVPI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AVPI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AVPI1 gene:
Search GeneIP for patents involving AVPI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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AVPI1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for AVPI1

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVPI1

	SwitchGear 3'UTR luciferase reporter plasmids for AVPI1
	SwitchGear Promoter luciferase reporter plasmids for AVPI1

ThermoFisher Antibodies for AVPI1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVPI1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AVPI1

Sirion Biotech Customized:

	stable knockdown cell line services for AVPI1
	inducible knockdown cell line services for AVPI1
	design and validation of potent shRNA sequences against AVPI1
	adenovirus for potent knockdown of AVPI1
	adenovirus for overexpression of AVPI1
	stable overexpressing cell line services for AVPI1
	inducible overexpressing cell line services for AVPI1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes AVPI1 gene at Home site.

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AVPI1 Gene

arginine vasopressin-induced 1

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Export list of displayed genes

AVPI1 Gene

arginine vasopressin-induced 1

Aliasesfor AVPI1 gene

Summariesfor AVPI1 gene

Genomic Viewsfor AVPI1 gene

Proteinsfor AVPI1 gene

Protein Domains /Familiesfor AVPI1 gene

Functionfor AVPI1 gene

Pathways & Interactionsfor AVPI1 gene

Drugs & Compoundsfor AVPI1 gene

Transcriptsfor AVPI1 gene

Expression for AVPI1 gene

Orthologsfor AVPI1 gene

Paralogsfor AVPI1 gene

Genomic Variantsfor AVPI1 gene

Disorders / Diseasesfor AVPI1 gene

Publicationsfor AVPI1 gene

External Searches for AVPI1 gene

Genome Databases showing AVPI1 gene

Other Databases showing AVPI1 gene

Specialized Databases showing AVPI1 gene

Intellectual Propertyfor AVPI1 gene

Productsfor AVPI1 gene

View Random Gene

Aliases
for AVPI1 gene

Summaries
for AVPI1 gene

Genomic Views
for AVPI1 gene

Proteins
for AVPI1 gene

Protein Domains /
Families
for AVPI1 gene

Function
for AVPI1 gene

Pathways & Interactions
for AVPI1 gene

Drugs & Compounds
for AVPI1 gene

Transcripts
for AVPI1 gene

Expression
for AVPI1 gene

Orthologs
for AVPI1 gene

Paralogs
for AVPI1 gene

Genomic Variants
for AVPI1 gene

Disorders / Diseases
for AVPI1 gene

Publications
for AVPI1 gene

Intellectual Property
for AVPI1 gene

Products
for AVPI1 gene