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AVP Gene

protein-coding   GIFtS: 62

GC20M003011
arginine vasopressin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ARVP)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ADH 1, 2
ARVP 2, 3
AVP-NPII 2, 3
AVRP 2, 5
OTTHUMP00000030089 2
VP 2, 3, 5
neurohypophyseal 2
Descriptions
antidiuretic hormone 2
arginine vasopressin 2
arginine vasopressin-neurophysin II 2
vasopressin-neurophysin II-copeptin 2
External Ids
HGNC: 8941
Entrez Gene: 5512
UniProtKB: P011853
Ensembl: ENSG000001012007
Search outside databases for aliases for AVP gene

Previous GC identifers: GC20M003051 GC20M003058

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for AVP:
This gene encodes a precursor protein consisting of arginine vasopressin and two associated
proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior
pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of
the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into
neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where
it is either stored or secreted into the bloodstream. The precursor is thought to be activated
while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts
as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct
antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels.
This hormone can contract smooth muscle during parturition and lactation. It is also involved in
cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the
regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal
dominant neurohypophyseal diabetes insipidus (ADNDI). [provided by RefSeq]

UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185
Function: Vasopressin has a direct antidiuretic action on the kidney, it also causes
vasoconstriction of the peripheral vessels

Gene Wiki entry for AVP (Vasopressin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AVP gene  

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

AVP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003011:     (about GC identifiers)

Start:
3,011,188 bp from pter
End:
3,013,370 bp from pter
Size:
2,183 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000020.9  NT_011387.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185 (See protein sequence)
Recommended Name: Vasopressin-neurophysin 2-copeptin precursor  
Size: 164 amino acids; 17325 Da
Subcellular location: Secreted
Secondary accessions: A0AV35 O14935

REFSEQ proteins: NP_000481.2  

ENSEMBL proteins: 
ENSP00000369647 ENSP00000382771 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for AVP  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Neurophysin 2, Vasopressin)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005625 soluble fraction TAS1740104
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Antibodies for AVP: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of AVP
Browse Antibodies at Sigma-Aldrich
R&D Systems Antibodies for AVP (Neurophysin II)
Antibodies from Abcam (Neurophysin 2, Vasopressin), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for AVP

Assays for AVP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR000981 Neurhyp_horm
 IPR016321 Nonapeptide_hormone_prcur


   GeneDecks  AVP for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P01185

ProtoNet protein and cluster: P01185

1 Blocks protein family: IPB000981 Neurohypophysial hormone

UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185
Similarity: Belongs to the vasopressin/oxytocin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (AVP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000490

              Applied Biosystems Silencer® siRNAs for AVP

              Sigma-Aldrich siRNA and siRNA Panels for AVP  
                     Sigma-Aldrich shRNA for AVP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000490
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000490
                                 untagged cDNA clone in CMV expression vector: NM_000490 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000490

UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185
Function: Neurophysin 2 specifically binds vasopressin
Function: Vasopressin has a direct antidiuretic action on the kidney, it also causes
vasoconstriction of the peripheral vessels

Genatlas biochemistry entry for AVP:
arginine vasopressin (neurophysin II,copeptide precursor)

7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Avp):

behavior/neurologicalendocrine/exocrine glandhomeostasis/metabolismlethality-postnatalnervous system
normalrenal/urinary system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005185 neurohypophyseal hormone activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Millipore Pathway for AVP
 Selected targets of CREB1

   GeneDecks  AVP for the pathways selected above  
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  AVP  (Your Favorite Gene powered by Ingenuity) 
 Circadian Rhythm Signaling

   GeneDecks  AVP for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  AVP 


5/67 Interacting proteins for AVP (ENSP000003696473) via UniProtKB, MINT, and/or STRING (see all 67 )
InteractantInteraction Details
GeneCardExternal ID(s)
AVPR2ENSP000003518053STRING (score=.999)
AVPR1AENSP000002991783STRING (score=.996)
ADHFE1ENSP000002765763STRING (score=.993)
OXTRENSP000003242703STRING (score=.991)
NPPAENSP000003656633STRING (score=.966)
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5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS1740104
GO:0006833 water transport TAS1740104
GO:0007165 signal transduction TAS8794883
GO:0007267 cell-cell signaling TAS1740104
GO:0042310 vasoconstriction IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for AVP available from Tocris Bioscience
CompoundAction CAS number
[Lys8]-VasopressinAntidiuretic hormone[50-57-7]
[Arg8]-VasopressinAntidiuretic hormone[113-79-1]
SR 49059Selective, orally active vasopressin V1a receptor antagonist[150375-75-0]
d[Leu4,Lys8]-VPSelective V1b agonist[42061-33-6]
d[Cha4]-AVPPotent and selective human V1b agonist[500170-27-4]
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10/19 Novoseek chemical compound relationships for AVP gene (see all 19 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
acth 46.91 20 8090286 (3), 8621793 (3), 12466375 (2), 9627097 (2) (see all 10)
sodium 35.67 14 2147645 (2), 9666340 (2), 2276581 (1), 14695699 (1) (see all 8)
phenylalanine 20.36 7 12359138 (2), 9022681 (1), 12931042 (1), 16682840 (1)
abscisic acid 14.79 9 8787023 (2), 8672884 (2)
thymine 11.82 1 10827849 (1)
ethanol 4.51 4 1468643 (1), 15554233 (1), 2264624 (1)
uric acid 4.47 1 8738818 (1)
tyrosine 1.83 8 16682840 (2), 11150885 (1), 11739373 (1), 17595538 (1) (see all 6)
catecholamine 0.91 1 7770002 (1)
melatonin 0.00 1 16837102 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (AVP)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000490

              Sigma-Aldrich siRNA and siRNA Panels for AVP  
                     Sigma-Aldrich shRNA for AVP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000490  

REFSEQ mRNAs for AVP gene: 

NM_000490.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000490  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000490
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000490
                                 untagged cDNA clone in CMV expression vector: NM_000490 

Additional cDNA sequence: 

AF031475.1 AF031476.1 BC018062.1 BC126196.1 BC126224.1 M25647.1 X03172.1 

1 DOTS entry:

DT.308297 

9 AceView cDNA sequences:

AI478178 NM_000490 AF031475 BC018062 BV204441 BG715518 AF031476 X03172 
M25647 

highest scoring ESTs for AVP:

AF031475 AF031476 BC018062 BG715518 M25647 X03172 AI478178 BG715231 NM_000490 BC126196 

Unigene Cluster for AVP:

Arginine vasopressin
Hs.89648  [show with all ESTs]
Unigene Representative Sequence: AF031475


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000380293  ENST00000399882  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AVP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for AVP

1 / 2 / 3

3 probe-sets matching AVP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

34020_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M11166 0.20 1.00 0.72 1

207848_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000490 0.60 1.00 0.82 1

207848_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.89648

Expression variation in blood from EXPOLDB for AVP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for AVP gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
AVP1   -- arginine vasopressin 90.65(n)
90.85(a)
403579  XM_542923.2  XP_542923.2 
chimpanzee
(Pan troglodytes)
AVP1   -- arginine vasopressin 97.36(n)
94.51(a)
746870  XM_001160259.1  XP_001160259.1 
cow
(Bos taurus)
AVP1   -- arginine vasopressin 91.67(n)
90.24(a)
280728  NM_176854.1  NP_789824.1 
rat
(Rattus norvegicus)
Avp1   -- arginine vasopressin 83.54(n)
80.49(a)
24221  NM_016992.1  NP_058688.1 
mouse
(Mus musculus)
Avp1, 5 2 (73.20 cM)5
arginine vasopressin1, 5 84.96(n)1
81.71(a)1
119981  NM_009732.11  NP_033862.11 
 AK1381795  AL7317075  (see all 7)
About this table        Species with no ortholog for AVP

ENSEMBL Gene Tree for AVP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for AVP gene
OXT2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/29 NCBI SNPs in AVP are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 23)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs37612491,2
A,C,F,H3014362(+) CACTTT/GTGGTC 1 -- ng315Minor allele frequency- G:0.31EA EU WA 1904
rs37299651,2
C,H3013547(-) TCCCCT/CATGAT 1 -- ng31 ese3 trp34Minor allele frequency- C:0.00EU EA WA 418
--
rs60374811,2
A,C3015194(+) agaaaC/Tggggt 1 -- ng310--------
--
rs51951,2
F3011700(-) CCTGCC/TGTCGC 1 P/L mis11Minor allele frequency- T:0.05MN 80
--
rs61157851,2
C3015109(+) caagcA/Gatcct 1 -- ng310--------
rs48155651,2
H3014556(+) AAATTC/TCAGGG 1 -- ng31 tfbs34Minor allele frequency- T:0.00EU EA WA 418
--
rs18878541,2
C3011161(+) CTCCCC/TTTCCC 1 -- ng510--------
rs37299641,2
H3013219(-) ATGTCC/TGACCT 1 S/S syn14Minor allele frequency- T:0.00EU EA WA 418
rs22820181,2
A,C,F,H3012949(+) CATTTT/CCCTGC 1 -- int14Minor allele frequency- C:0.40EA WA 1798
rs37874821,2
C,F3012110(+) GGGGAG/ACCCTT 1 -- int11Minor allele frequency- A:0.27EA 1498
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HapMap Linkage Disequilibrium images for AVP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 192340   disorders: 125700  

UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185

  • Defects in AVP are the cause of autosomal dominant neurohypophyseal diabetes insipidus
    (ADNDI) [MIM:125700]. ADNDI is characterized by persistent thirst, polydipsia and polyuria. The
    disease is transmitted in an autosomal dominant mode and appears to be largely if not completely
    penetrant
  • Defects in AVP are the cause of autosomal recessive neurohypophyseal diabetes insipidus
    (ARNDI) [MIM:125700]. ARNDI is characterized by persistent thirst, polydipsia and polyuria. Most
    mutations are hypothesized to trigger neurodegeneration via disruption of preproAVP-NPII
    processing
  • 10/24 Novoseek disease relationships for AVP gene (see all 24 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    central diabetes insipidus 94.65 53 7714110 (3), 11150885 (2), 1840604 (2), 8706292 (2) (see all 35)
    hyponatremia 64.27 18 9100572 (2), 2153841 (2), 18984663 (2), 10614173 (2) (see all 10)
    siadh 62.94 9 9100572 (2), 1656520 (2), 16797399 (1), 10614173 (1)
    diabetes insipidus nephrogenic 59.40 3 17941907 (1), 7541187 (1), 16093448 (1)
    carcinoma oat cell 56.05 3 1966564 (2)
    hyperosmolality 37.50 1 1656520 (1)
    panhypopituitarism 34.18 1 10596369 (1)
    shock septic 33.08 8 17515850 (3), 19325368 (1), 15922490 (1), 19114902 (1) (see all 6)
    critically ill 30.34 8 16940457 (3), 16269513 (2), 16913350 (1), 17635944 (1) (see all 5)
    sepsis 25.59 17 17515850 (2), 16269513 (2), 18252006 (2), 16940457 (2) (see all 9)
    About this table

    Human Gene Mutation Database: AVP
    Genetic Association Database: AVP
    Human Genome Epidemiology Navigator: AVP (41 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/248 PubMed articles for AVP gene (see all 248 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 551 HGNC: 894 AceView: AVP Ensembl:ENSG00000101200 euGenes: HUgn551
    ECgene: AVP H-InvDB: AVP
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=AVP
    Wikipedia http://en.wikipedia.org/wiki/Vasopressin
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for AVP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for AVP Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Proteins for AVP
     Lentivirus-delivered shRNAs for AVP Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (Neurophysin 2, Vasopressin)
     Antibodies (Neurophysin 2, Vasopressin)
     Search OriGene for AVP
     Tocris compounds for AVP




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for AVP

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