Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AVP Gene

protein-coding   GIFtS: 65
GCID: GC20M003063

Arginine Vasopressin


(Previous symbol: ARVP)
  See AVP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Arginine Vasopressin1 2     AVP-NPII2 3
ARVP1 2 3     AVRP2 5
VP2 3 5     Diabetes Insipidus1
Antidiuretic Hormone1 2     Neurophysin II1
neurohypophyseal1 2     ADH2
Prepro-Arginine-Vasopressin-Neurophysin II1 2     Vasopressin-Neurophysin 2-Copeptin2
Prepro-AVP-NP II1 2     Vasopressin-Neurophysin II-Copeptin2

External Ids:    HGNC: 8941   Entrez Gene: 5512   Ensembl: ENSG000001012007   OMIM: 1923405   UniProtKB: P011853   
ORGUL members:         

Export aliases for AVP gene to outside databases

Previous GC identifers: GC20M003051 GC20M003011 GC20M003058


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for AVP Gene:
This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin
2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the
supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin
2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the
neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be
activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a
growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action
on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth
muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex
sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). (provided by RefSeq,
Mar 2010)

GeneCards Summary for AVP Gene:
AVP (arginine vasopressin) is a protein-coding gene. Diseases associated with AVP include syndrome of inappropriate antidiuretic hormone, and inappropriate adh syndrome. GO annotations related to this gene include protein kinase activity and receptor binding. An important paralog of this gene is OXT.

UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185
Function: Neurophysin 2 specifically binds vasopressin
Function: Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the
peripheral vessels

summary for AVP Gene:
Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis
and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to
oxytocin receptors (OT). V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle
cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found
to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in
the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively
on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

Gene Wiki entry for AVP (Vasopressin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the AVP gene promoter:
         NRSF form 1   Egr-1   NRSF form 2   Tal-1beta   E47   S8   PPAR-gamma1   c-Myb   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAVP promoter sequence
   Search Chromatin IP Primers for AVP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AVP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

AVP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003063:  view genomic region     (about GC identifiers)

Start:
3,063,202 bp from pter      End:
3,065,370 bp from pter
Size:
2,169 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185 (See protein sequence)
Recommended Name: Vasopressin-neurophysin 2-copeptin precursor  
Size: 164 amino acids; 17325 Da
Secondary accessions: A0AV35 O14935

Explore the universe of human proteins at neXtProt for AVP: NX_P01185

Explore proteomics data for AVP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn131

  • See AVP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000481.2  
    ENSEMBL proteins: 
     ENSP00000369647  
    Reactome Protein details: P01185

    AVP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for AVP
    OriGene Protein Over-expression Lysate for AVP
    OriGene MassSpec for AVP
    OriGene Custom Protein Services for AVP
    GenScript Custom Purified and Recombinant Proteins Services for AVP
    Novus Biologicals AVP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for AVP
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AVP 

     
    antibodies-online proteins for AVP (19 products) 

     
    antibodies-online peptides for AVP

    AVP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AVP
    R&D Systems Antibodies for AVP (Copeptin, Neurophysin II)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AVP
    Novus Biologicals AVP Antibody
    Abcam antibodies for AVP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for AVP
    antibodies-online antibodies for AVP (82 products) 

    AVP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AVP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AVP
    Enzo Life Sciences assays for AVP
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AVP 
    antibodies-online kits for AVP (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR022423 Neurohypophysial_hormone_CS
     IPR000981 Neurhyp_horm

    Graphical View of Domain Structure for InterPro Entry P01185

    ProtoNet protein and cluster: P01185

    1 Blocks protein domain: IPB000981 Neurohypophysial hormone

    UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185
    Similarity: Belongs to the vasopressin/oxytocin family


    Find genes that share domains with AVP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEU2_HUMAN, P01185
    Function: Neurophysin 2 specifically binds vasopressin
    Function: Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the
    peripheral vessels

         Genatlas biochemistry entry for AVP:
    arginine vasopressin (neurophysin II,copeptide precursor)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA18402937
    GO:0004871signal transducer activity IDA18402937
    GO:0005102receptor binding TAS1740104
    GO:0005184neuropeptide hormone activity TAS1740104
    GO:0005185neurohypophyseal hormone activity IEA--
         
    Find genes that share ontologies with AVP           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Avp):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system  normal 
     renal/urinary system 

    Find genes that share phenotypes with AVP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AVP

    miRNA
    Products:
        
    miRTarBase miRNAs that target AVP:
    hsa-mir-335-5p (MIRT018794)

    Block miRNA regulation of human, mouse, rat AVP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AVP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AVP
    Predesigned siRNA for gene silencing in human, mouse, rat AVP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AVP

    Clone
    Products:
         
    OriGene clones in human, mouse for AVP (see all 5)
    OriGene ORF clones in mouse, rat for AVP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AVP (NM_000490)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVP
    Addgene plasmids for AVP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AVP
    Browse ESI BIO Cell Lines and PureStem Progenitors for AVP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NEU2_HUMAN, P01185: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    endosome2
    golgi apparatus2
    nucleus2
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005829cytosol TAS--
    GO:0030141secretory granule IEA--
    GO:0030425dendrite IEA--

    Find genes that share ontologies with AVP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for AVP About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    Vasopressin-like receptors0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Aquaporin-mediated transport0.85
    5Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66


    Find genes that share SuperPaths with AVP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for AVP
        SIDS Susceptibility Pathways

    Selected Reactome Pathways for AVP (see all 6)
        G alpha (q) signalling events
    Vasopressin-like receptors
    Transport of organic anions
    Regulation of water balance by renal Aquaporins
    BMAL1:CLOCK,NPAS2 activates circadian gene expression


    1 Kegg Pathway  (Kegg details for AVP):
        Vasopressin-regulated water reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AVP: 
              Hypertension in human mouse rat
              GABA & Glutamate in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AVP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for AVP (P011853 ENSP000003696474) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TXNDC17Q9BRA23, ENSP000002501014I2D: score=2 STRING: ENSP00000250101
    AVPR1BP479013, ENSP000003560944I2D: score=1 STRING: ENSP00000356094
    AVPR1AP372883, ENSP000002991784I2D: score=1 STRING: ENSP00000299178
    AVPR2P305183, ENSP000003380724I2D: score=1 STRING: ENSP00000338072
    OXTRP305593, ENSP000003242704I2D: score=1 STRING: ENSP00000324270
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002125maternal aggressive behavior IEA--
    GO:0003084positive regulation of systemic arterial blood pressure IEA--
    GO:0006091generation of precursor metabolites and energy TAS1740104
    GO:0006468protein phosphorylation IDA18402937
    GO:0006833water transport TAS--

    Find genes that share ontologies with AVP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for AVP
      Browse compounds at ApexBio 

    Compounds for AVP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    d[Leu4,Lys8]-VP Selective V1B agonist[42061-33-6]
    [Arg8]-VasopressinAntidiuretic hormone[113-79-1]
    SR 49059 Selective, orally active vasopressin V1A receptor antagonist [150375-75-0]
    DesmopressinSynthetic vasopressin analog; V1B and V2 agonist[16679-58-6]
    (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Selective vasopressin V1A antagonist[73168-24-8]

    Selected Novoseek inferred chemical compound relationships for AVP gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 79.4 106 8045958 (3), 11748489 (3), 9467595 (3), 16913350 (3) (see all 61)
    desmopressin 58.6 11 8940142 (3), 8039334 (2), 17941907 (1)
    acth 48.8 20 8090286 (3), 8621793 (3), 12466375 (2), 9627097 (2) (see all 10)
    sodium 36.7 15 2147645 (2), 9666340 (2), 2276581 (1), 14695699 (1) (see all 9)
    phenylalanine 18.2 7 12359138 (2), 9022681 (1), 12931042 (1), 16682840 (1)
    guanine 16.1 3 20520956 (2), 10827849 (1)
    cysteine 12.5 7 12359138 (2), 11150885 (1), 8461298 (1), 10827849 (1) (see all 5)
    abscisic acid 11.1 9 8787023 (2), 8672884 (2)
    thymine 9.38 1 10827849 (1)
    creatinine 4.78 2 20447532 (1), 9666340 (1)



    Find genes that share compounds with AVP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AVP gene: 
    NM_000490.4  

    Unigene Cluster for AVP:

    Arginine vasopressin
    Hs.89648  [show with all ESTs]
    Unigene Representative Sequence: AF031475
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380293(uc002whu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AVP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AVP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AVP
    Predesigned siRNA for gene silencing in human, mouse, rat AVP
    Clone
    Products:
         
    OriGene clones in human, mouse for AVP (see all 5)
    OriGene ORF clones in mouse, rat for AVP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AVP (NM_000490)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVP
    Addgene plasmids for AVP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for AVP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AVP
      QuantiTect SYBR Green Assays in human, mouse, rat AVP
      QuantiFast Probe-based Assays in human, mouse, rat AVP

    Additional mRNA sequence: 

    AF031475.1 AF031476.1 BC018062.1 BC126196.1 BC126224.1 M25647.1 X03172.1 

    1 DOTS entry:

    DT.308297 

    9 AceView cDNA sequences:

    AI478178 NM_000490 BV204441 BC018062 AF031475 AF031476 X03172 BG715518 
    M25647 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AVP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AVP Expression
    About this image


    AVP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    AVP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AVP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89648
        Pathway & Disease-focused RT2 Profiler PCR Arrays including AVP: 
              Hypertension in human mouse rat
              GABA & Glutamate in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for AVP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AVP
    QuantiTect SYBR Green Assays in human, mouse, rat AVP
    QuantiFast Probe-based Assays in human, mouse, rat AVP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AVP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Avp1 , 5 arginine vasopressin1, 5 84.96(n)1
    81.71(a)1
      2 (63.24 cM)5
    119981  NM_009732.11  NP_033862.11 
     1305806205 
    chicken
    (Gallus gallus)
    Aves AVP1 arginine vasopressin (neurophysin II, antidiuretic more 68.67(n)
    61.33(a)
      396101  NM_205185.2  NP_990516.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1419962402   -- 74.44(n)    141996240 
    zebrafish
    (Danio rerio)
    Actinopterygii vsnp2 vasotocin neurophysin 72.98(n)   352922  AY168623.1 


    ENSEMBL Gene Tree for AVP (if available)
    TreeFam Gene Tree for AVP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AVP gene
    OXT2  
    1 SIMAP similar gene for AVP using alignment to 4 protein entries:     NEU2_HUMAN (see all proteins):
    OXT

    Find genes that share paralogs with AVP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AVP (see all 142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289348781,2,,4
    CDiabetes insipidus, neurohypophyseal (NDI)4 pathogenic13007342(-) CTTCGC/TGGGCA 2 A V mis1 ese30--------
    VAR_0049834
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0049832 G R mis40--------
    VAR_0192764
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0192762 C W mis40--------
    VAR_0299984
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0299982 C S mis40--------
    VAR_0049844
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0049842 G V mis40--------
    VAR_0152694
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0152692 S F mis40--------
    VAR_0152674
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0152672 C R mis40--------
    VAR_0049864
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0049862 P L mis40--------
    VAR_0152704
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0152702 C Y mis40--------
    VAR_0152634
    Diabetes insipidus, neurohypophyseal (NDI)4--see VAR_0152632 P L mis40--------

    HapMap Linkage Disequilibrium report for AVP (3063202 - 3065370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AVP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833897CNV Loss17160897
    nsv912603CNV Gain21882294

    Human Gene Mutation Database (HGMD): AVP
    Locus Specific Mutation Databases (LSDB): AVP

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AVP
    DNA2.0 Custom Variant and Variant Library Synthesis for AVP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 192340   
    OMIM disorders: 125700  
    UniProtKB/Swiss-Prot: NEU2_HUMAN, P01185
  • Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]: A disease characterized by persistent thirst,
    polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop
    symptoms of vasopressin deficiency during childhood. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 15 diseases for AVP:    
    About MalaCards
    syndrome of inappropriate antidiuretic hormone    inappropriate adh syndrome    neurohypophyseal diabetes insipidus    neurogenic diabetes insipidus
    fanconi syndrome    nephrogenic syndrome of inappropriate antidiuresis    diabetes insipidus    endolymphatic hydrops
    pituitary apoplexy    myxedema    bartter disease    nephrogenic diabetes insipidus
    septic shock    vascular dementia    neuroblastoma

    17 diseases from the University of Copenhagen DISEASES database for AVP:
    Diabetes insipidus     Inappropriate ADH syndrome     Neurohypophyseal diabetes insipidus     Nephrogenic diabetes insipidus
    Hypertension     Congestive heart failure     Hypopituitarism     Kidney failure
    Bartter disease     Brain disease     Liver cirrhosis     Craniopharyngioma
    Meningitis     Hypothyroidism     Germinoma     Hypoglycemia
    Olfactory neuroblastoma

    Find genes that share disorders with AVP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AVP gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    central diabetes insipidus 94.5 54 7714110 (3), 11150885 (2), 1840604 (2), 8706292 (2) (see all 36)
    hyponatremia 62.4 18 9100572 (2), 2153841 (2), 18984663 (2), 10614173 (2) (see all 10)
    siadh 61.2 9 9100572 (2), 1656520 (2), 16797399 (1), 10614173 (1)
    diabetes insipidus nephrogenic 57.6 3 17941907 (1), 7541187 (1), 16093448 (1)
    carcinoma oat cell 54.9 3 1966564 (2)
    hyperosmolality 54.4 1 1656520 (1)
    critically ill 33.6 8 16940457 (3), 16269513 (2), 16913350 (1), 17635944 (1) (see all 5)
    sepsis 32.1 18 17515850 (2), 16269513 (2), 18252006 (2), 16940457 (2) (see all 10)
    panhypopituitarism 31.9 1 10596369 (1)
    shock septic 30.6 8 17515850 (3), 19325368 (1), 15922490 (1), 19114902 (1) (see all 6)

    Genetic Association Database (GAD): AVP
    Human Genome Epidemiology (HuGE) Navigator: AVP (82 documents)

    Export disorders for AVP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AVP gene, integrated from 10 sources (see all 330):
    (articles sorted by number of sources associating them with AVP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus. (PubMed id 8045958)1, 2, 4, 9 Repaske D.R. and Browning J.E. (J. Clin. Endocrinol. Metab. 1994)
    2. Two novel mutations of the vasopressin gene associated with familial diabetes insipidus and identification of an asymptomatic carrier infant. (PubMed id 9814475)1, 2, 4 Grant F.D.... Majzoub J.A. (J. Clin. Endocrinol. Metab. 1998)
    3. A missense mutation encoding Cys73Phe in neurophysin II is associated with autosomal dominant neurohypophyseal diabetes insipidus. (PubMed id 12359138)1, 2, 9 Santiprabhob J.... Repaske D.R. (Mol. Genet. Metab. 2002)
    4. Identification of a novel mutation in the arginine vasopressin- neurophysin II gene affecting the sixth intrachain disulfide bridge of the neurophysin II moiety. (PubMed id 15538939)1, 2, 9 Baglioni S.... Peri A. (Eur. J. Endocrinol. 2004)
    5. Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. (PubMed id 7714110)1, 2, 9 Nagasaki H.... Oiso Y. (J. Clin. Endocrinol. Metab. 1995)
    6. A new mutation of the arginine vasopressin-neurophysin II gene in a family with autosomal dominant neurohypophyseal diabetes insipidus. (PubMed id 11748489)1, 2, 9 Mundschenk J.... Lehnert H. (Exp. Clin. Endocrinol. Diabetes 2001)
    7. A novel arginine vasopressin-neurophysin II mutation causes autosomal dominant neurohypophyseal diabetes insipidus and morphologic pituitary changes. (PubMed id 11150885)1, 2, 9 Skordis N.... Phillips J.A. III (Horm. Res. 2000)
    8. A single base substitution in the coding region for neurophysin II associated with familial central diabetes insipidus. (PubMed id 1840604)1, 3, 9 Ito M.... Saito H. (J. Clin. Invest. 1991)
    9. Progressive decline of vasopressin secretion in familial autosomal dominant neurohypophyseal diabetes insipidus presenting a novel mutation in the vasopressin-neurophysin II gene. (PubMed id 14510916)1, 2, 9 Elias P.C.L.... Castro M. (Clin. Endocrinol. (Oxf.) 2003)
    10. A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus. (PubMed id 11161827)1, 2, 9 DiMeglio L.A....Repaske D.R. (Mol. Genet. Metab. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 551 HGNC: 894 AceView: AVP Ensembl:ENSG00000101200 euGenes: HUgn551
    ECgene: AVP Kegg: 551 H-InvDB: AVP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AVP Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=AVP[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Vasopressin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AVP gene:
    Search GeneIP for patents involving AVP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of AVP
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for AVP (Copeptin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AVP  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for AVP  
     OriGene MassSpec for AVP   OriGene clones in human, mouse for AVP  
     OriGene qSTAR qPCR primer pairs in human, mouse for AVP   OriGene Purified Protein for AVP  
     OriGene ORF clones in mouse, rat for AVP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AVP   OriGene Custom Protein Services for AVP  

     
     
     Block miRNA regulation of human, mouse, rat AVP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AVP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AVP Predesigned siRNA for gene silencing in human, mouse, rat AVP
     QuantiFast Probe-based Assays in human, mouse, rat AVP QuantiTect SYBR Green Assays in human, mouse, rat AVP
     PCR Arrays including human, mouse, rat AVP Search Chromatin IP Primers for AVP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AVP  GeneGlobe Interaction Network for AVP
     Regulatory tfbs in AVP promoter
     GenScript Custom Purified and Recombinant Proteins Services for AVP GenScript cDNA clones with any tag delivered in your preferred vector for AVP
     GenScript Custom Assay Services for AVP GenScript Custom overexpressing Cell Line Services for AVP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for AVP
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Drugs for AVP
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AVP antibodies
     AVP lysates
     Antibodies for AVP
     See all of Abcam's Antibodies, Kits and Proteins for AVP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AVP
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for AVP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVP
     Browse SwitchGear 3'UTR luciferase reporter plasmids for AVP
     SwitchGear Promoter luciferase reporter plasmids for AVP
     ThermoFisher Antibodies for AVP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVP
     Browse compounds at ApexBio
     Addgene plasmids for AVP
      Search eBioscience for proteins for AVP
      Search eBioscience for elisas for AVP
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for AVP
     antibodies-online antibodies for AVP (82 products)
     antibodies-online kits for AVP (29 products)
     antibodies-online peptides for AVP
     antibodies-online proteins for AVP (19 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AVP gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4