Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AVL9 Gene

Aliases for AVL9 Gene

  • AVL9 Homolog (S. Cerevisiase) 2 3
  • KIAA0241 2 3 4 6
  • Late Secretory Pathway Protein AVL9 Homolog 3

External Ids for AVL9 Gene

Previous Symbols for AVL9 Gene

  • KIAA0241

Summaries for AVL9 Gene

GeneCards Summary for AVL9 Gene

AVL9 (AVL9 Homolog (S. Cerevisiase)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AVL9 Gene

  • Functions in cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AVL9 Gene

Genomics for AVL9 Gene

Genomic Location for AVL9 Gene

Start:
32,495,426 bp from pter
End:
32,588,721 bp from pter
Size:
93,296 bases
Orientation:
Plus strand

Genomic View for AVL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AVL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AVL9 Gene

Regulatory Elements for AVL9 Gene

Proteins for AVL9 Gene

  • Protein details for AVL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBF6-AVL9_HUMAN
    Recommended name:
    Late secretory pathway protein AVL9 homolog
    Protein Accession:
    Q8NBF6
    Secondary Accessions:
    • Q92573

    Protein attributes for AVL9 Gene

    Size:
    648 amino acids
    Molecular mass:
    71947 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AVL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AVL9 Gene

Proteomics data for AVL9 Gene at MOPED

Post-translational modifications for AVL9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys465

Other Protein References for AVL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AVL9 Gene

Domains for AVL9 Gene

Protein Domains for AVL9 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AVL9_HUMAN
Family:
  • Belongs to the AVL9 family.:
    • Q8NBF6
genes like me logo Genes that share domains with AVL9: view

No data available for Gene Families for AVL9 Gene

Function for AVL9 Gene

Molecular function for AVL9 Gene

UniProtKB/Swiss-Prot Function: Functions in cell migration.

miRNA for AVL9 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AVL9 Gene

Localization for AVL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AVL9 Gene

Recycling endosome. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AVL9 Gene COMPARTMENTS Subcellular localization image for AVL9 gene
Compartment Confidence
endosome 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for AVL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0055037 recycling endosome IDA 22595670
genes like me logo Genes that share ontologies with AVL9: view

Pathways for AVL9 Gene

SuperPathways for AVL9 Gene

No Data Available

Interacting Proteins for AVL9 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315568%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000298532%0d%0a9606.ENSP00000345702%0d%0a9606.ENSP00000350199%0d%0a9606.ENSP00000314414%0d%0a
Selected Interacting proteins: ENSP00000315568 Q8NBF6-AVL9_HUMAN for AVL9 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for AVL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IDA 22595670
genes like me logo Genes that share ontologies with AVL9: view

No data available for Pathways by source for AVL9 Gene

Transcripts for AVL9 Gene

Unigene Clusters for AVL9 Gene

AVL9 homolog (S. cerevisiase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AVL9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - -
SP3:

Relevant External Links for AVL9 Gene

GeneLoc Exon Structure for
AVL9
ECgene alternative splicing isoforms for
AVL9

Expression for AVL9 Gene

mRNA expression in normal human tissues for AVL9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AVL9 Gene

SOURCE GeneReport for Unigene cluster for AVL9 Gene Hs.128056

genes like me logo Genes that share expressions with AVL9: view

Orthologs for AVL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AVL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AVL9 36
  • 99.64 (n)
  • 99.85 (a)
AVL9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AVL9 36
  • 90.45 (n)
  • 93.04 (a)
AVL9 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AVL9 36
  • 91.84 (n)
  • 93.35 (a)
AVL9 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Avl9 36
  • 89.35 (n)
  • 91.51 (a)
Avl9 16
Avl9 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AVL9 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AVL9 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Avl9 36
  • 89.4 (n)
  • 91.2 (a)
chicken
(Gallus gallus)
Aves AVL9 36
  • 76.71 (n)
  • 81.73 (a)
AVL9 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AVL9 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia avl9 36
  • 71.98 (n)
  • 77.34 (a)
Str.18105 36
zebrafish
(Danio rerio)
Actinopterygii avl9 36
  • 65.37 (n)
  • 66.91 (a)
avl9 37
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000251 36
  • 51.6 (n)
  • 46.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11178 36
  • 47.23 (n)
  • 40.79 (a)
CG11178 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T26A5.6 36
  • 52.4 (n)
  • 44.16 (a)
T26A5.6 37
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVL9 37
  • 21 (a)
OneToOne
AVL9 39
Species with no ortholog for AVL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AVL9 Gene

ENSEMBL:
Gene Tree for AVL9 (if available)
TreeFam:
Gene Tree for AVL9 (if available)

Paralogs for AVL9 Gene

No data available for Paralogs for AVL9 Gene

Variants for AVL9 Gene

Sequence variations from dbSNP and Humsavar for AVL9 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs702830 -- 32,540,036(+) aacaa(A/T)tagag intron-variant
rs702831 -- 32,540,103(+) GTGGC(C/T)GTCTT intron-variant
rs764483 -- 32,538,538(+) CTGTA(A/T)GTTTG intron-variant
rs787212 -- 32,536,819(+) ctctt(C/T)gcttg intron-variant
rs787213 -- 32,538,138(+) AGTTG(C/G)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AVL9 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv887921 CNV Gain 21882294
nsv887922 CNV Gain 21882294
esv3153 CNV Deletion 18987735
esv29644 CNV Gain 19812545
nsv820638 CNV Deletion 20802225
esv2676855 CNV Deletion 23128226
esv996889 CNV Insertion 20482838
nsv887923 CNV Loss 21882294

Relevant External Links for AVL9 Gene

HapMap Linkage Disequilibrium report
AVL9

Disorders for AVL9 Gene

(1) University of Copenhagen DISEASES for AVL9 Gene

Relevant External Links for AVL9

Genetic Association Database (GAD)
AVL9
genes like me logo Genes that share disorders with AVL9: view

No data available for UniProtKB/Swiss-Prot for AVL9 Gene

Publications for AVL9 Gene

  1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A. … Barr F.A. (Dev. Cell 2012) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway. (PMID: 17229886) Harsay E. … Schekman R. (Mol. Biol. Cell 2007) 2 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for AVL9 Gene

Sources for AVL9 Gene

Back to Top

Content