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AVIL Gene

protein-coding   GIFtS: 53
GCID: GC12M058191

Advillin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
advillin1 2
p922 3
ADVIL2
DOC62

External Ids:    HGNC: 141881   Entrez Gene: 106772   Ensembl: ENSG000001354077   OMIM: 6133975   UniProtKB: O753663   

Export aliases for AVIL gene to outside databases

Previous GC identifers: GC12M057793 GC12M058334 GC12M057907 GC12M056477 GC12M055228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AVIL Gene:
The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This
protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal
cells that form ganglia. (provided by RefSeq, Jul 2008)

GeneCards Summary for AVIL Gene:
AVIL (advillin) is a protein-coding gene. Diseases associated with AVIL include lennox-gastaut syndrome, and dacryoadenitis. GO annotations related to this gene include actin binding. An important paralog of this gene is SVIL.

UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366
Function: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal
cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in
regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the
formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AVIL gene promoter:
         HFH-3   Egr-3   AML1a   HOXA3   Ik-3   E47   HEN1   FOXI1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAVIL promoter sequence
   Search Chromatin IP Primers for AVIL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AVIL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13.11

AVIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVIL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058191:  view genomic region     (about GC identifiers)

Start:
58,191,159 bp from pter      End:
58,212,487 bp from pter
Size:
21,329 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366 (See protein sequence)
Recommended Name: Advillin  
Size: 819 amino acids; 92027 Da
Subunit: Associates (via C-terminus) with actin. Interacts with SCARF1 (By similarity). Interacts with F-actin
1 PDB 3D structure from and Proteopedia for AVIL:
1UND (3D)    
Secondary accessions: B2RAU7 Q2NKM9
Alternative splicing: 2 isoforms:  O75366-1   O75366-2   

Explore the universe of human proteins at neXtProt for AVIL: NX_O75366

Explore proteomics data for AVIL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AVIL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006567.3  
    ENSEMBL proteins: 
     ENSP00000450188   ENSP00000257861   ENSP00000449239   ENSP00000443207  

    AVIL Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for AVIL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007122 Villin/Gelsolin
     IPR003128 Villin_headpiece
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry O75366

    ProtoNet protein and cluster: O75366

    3 Blocks protein domains:
    IPB003128 Villin headpiece
    IPB007122 Gelsolin family signature
    IPB007123 Gelsolin region


    UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366
    Similarity: Belongs to the villin/gelsolin family
    Similarity: Contains 6 gelsolin-like repeats
    Similarity: Contains 1 HP (headpiece) domain


    AVIL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AVIL_HUMAN, O75366
    Function: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal
    cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in
    regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the
    formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005515protein binding ----
         
    AVIL for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AVIL:
     Decreased cilium length  Decreased cilium length after  

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Avil):
     behavior/neurological  cellular  integument  limbs/digits/tail  mortality/aging 
     nervous system  no phenotypic analysis 

    AVIL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AVIL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AVIL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AVIL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AVIL

    miRNA
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    miRTarBase miRNAs that target AVIL:
    hsa-mir-9-5p (MIRT021358)

    Block miRNA regulation of human, mouse, rat AVIL using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate AVIL:
    hsa-miR-1290 hsa-miR-520f hsa-miR-562 hsa-miR-3143 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidAVIL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AVIL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: AVIL (NM_006576)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVIL

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVIL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AVIL_HUMAN, O75366: Cytoplasm, cytoskeleton. Cell projection (By similarity). Cell projection, axon (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0015629actin cytoskeleton TAS9664034
    GO:0030424axon IEA--
    GO:0042995cell projection ISS--
    GO:0043005neuron projection ISS--

    AVIL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AVIL
    Interactions:

        Search GeneGlobe Interaction Network for AVIL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for AVIL (O753663 ENSP000002578614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    HDAC8ENSP000003626744STRING: ENSP00000362674
    FSCN1ENSP000003717984STRING: ENSP00000371798
    FSCN2ENSP000003346654STRING: ENSP00000334665
    FSCN3ENSP000002658254STRING: ENSP00000265825
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress ----
    GO:0007010cytoskeleton organization IEA--
    GO:0007399nervous system development TAS9664034
    GO:0010976positive regulation of neuron projection development ISS--
    GO:0051693actin filament capping IEA--

    AVIL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AVIL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AVIL gene: 
    NM_006576.3  

    Unigene Cluster for AVIL:

    Advillin
    Hs.584854  [show with all ESTs]
    Unigene Representative Sequence: NM_006576
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546952 ENST00000549851 ENST00000551248 ENST00000257861 ENST00000550537(uc001sqk.1)
    ENST00000550083 ENST00000549548 ENST00000549753 ENST00000548843(uc001sql.4)
    ENST00000549994 ENST00000537081(uc001sqj.2 uc009zqe.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat AVIL using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate AVIL:
    hsa-miR-1290 hsa-miR-520f hsa-miR-562 hsa-miR-3143 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidAVIL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for AVIL
    Predesigned siRNA for gene silencing in human, mouse, rat AVIL
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    OriGene ORF clones in mouse, rat for AVIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AVIL (NM_006576)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVIL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AVIL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AVIL
      QuantiTect SYBR Green Assays in human, mouse, rat AVIL
      QuantiFast Probe-based Assays in human, mouse, rat AVIL

    Additional mRNA sequence: 

    AF041449.1 AF318328.1 AK022448.1 AK314362.1 BX647344.1 XR_159030.2 XR_159219.2 XR_171957.1 

    13 DOTS entries:

    DT.112342  DT.455328  DT.97868569  DT.121200921  DT.101961055  DT.421093  DT.40250470  DT.437665 
    DT.100045490  DT.40256148  DT.211446  DT.40120459  DT.70100979 

    Selected AceView cDNA sequences (see all 66):

    AA410634 BM510486 BQ893208 F04173 F02365 NM_006576 AA434298 AA534371 
    BM713863 AI288722 BE139483 AI458294 AI215450 AI050859 BX647344 CA848547 
    AW410212 AI458701 AA427733 BU617924 BI114542 AW081692 AI925174 AF041449 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AVIL    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                                              -                                         -                             -           -         
    SP2:                                                                                                        -                       -     -     -               
    SP3:        -                                                                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -         

    ExUns: 20a · 20b · 20c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AVIL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AVIL expression in normal human tissues (normalized intensities)      AVIL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCCATTT
    AVIL Expression
    About this image


    AVIL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neural Tube (Nervous System)
             Metencephalon
    AVIL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AVIL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584854

    UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366
    Tissue specificity: Most highly expressed in the small intestine and colonic lining. Weaker expression also
    detected in the thymus, prostate, testes and uterus

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    QuantiFast Probe-based Assays in human, mouse, rat AVIL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVIL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AVIL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Avil1 , 5 advillin1, 5 86.77(n)1
    89.5(a)1
      10 (74.48 cM)5
    115671  NM_009635.31  NP_033765.21 
     1270007095 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    54(a)
    many ↔ many
    2(4562087-4592894)
    lizard
    (Anolis carolinensis)
    Reptilia AVIL6
    advillin
    71(a)
    1 ↔ 1
    2(66980914-67021231)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.52422 Transcribed sequence with weak similarity to protein more 76.41(n)    137723683 
    zebrafish
    (Danio rerio)
    Actinopterygii avil1 advillin 65.92(n)
    64.81(a)
      678618  NM_001040365.1  NP_001035455.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VLN21 VLN2 47.31(n)
    37.59(a)
      818773  NM_129738.4  NP_565958.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03567001 Os03g0356700 46.21(n)
    34.88(a)
      4332869  NM_001056675.1  NP_001050140.1 


    ENSEMBL Gene Tree for AVIL (if available)
    TreeFam Gene Tree for AVIL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AVIL gene
    SVIL2  FLII2  VILL2  SCIN2  GSN2  CAPG2  VIL12  
    8 SIMAP similar genes for AVIL using alignment to 3 protein entries:     AVIL_HUMAN (see all proteins):
    VIL1    DKFZp313L0718    VILL    GSN    SVIL    CAPG
    SCIN    FLII

    AVIL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AVIL (see all 381)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470364961,2
    C--58197143(+) GAGACG/AAGACT 2 /R /C mis11Minor allele frequency- A:0.00NA 4552
    rs2014958111,2
    --58197169(+) CCTGCC/TGAAGT 2 Q R mis10--------
    rs1896609761,2
    C--58197180(+) CTGCAA/GTATAG 1 -- int10--------
    rs1930382071,2
    C,F--58197182(+) GCAATA/GTAGTC 1 -- int11Minor allele frequency- G:0.01EU 1323
    rs607804891,2
    C--58197231(+) ACTGAG/TGTTTT 1 -- int12Minor allele frequency- T:0.02EA EU 713
    rs2005193921,2
    --58197323(+) GGCATA/GGGGAG 2 H Y mis10--------
    rs1426061171,2
    C,F--58197363(+) GCTGGC/TTCCTG 2 E syn12Minor allele frequency- T:0.01NA EU 5813
    rs1996943461,2
    --58197434(+) TGCCCA/GCTCAT 2 R W mis10--------
    rs2019654361,2
    C--58197442(+) CATCCA/C/GCACTA 3 A G V mis10--------
    rs2013677171,2
    C--58197466(+) GGGGCG/AAGGAG 1 -- int11Minor allele frequency- A:0.00EU 1323

    HapMap Linkage Disequilibrium report for AVIL (58191159 - 58212487 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AVIL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510601CNV Loss20534489
    nsv470297CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613397    OMIM disorders: --

    8 diseases for AVIL:    About MalaCards
    lennox-gastaut syndrome    dacryoadenitis    dengue hemorrhagic fever    hemorrhagic fever
    inflammatory bowel disease    neuronitis    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for AVIL:
    Lennox-Gastaut syndrome

    AVIL for disorders           About GeneDecksing


    Export disorders for AVIL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AVIL gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with AVIL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins. (PubMed id 9664034)1, 2, 3, 9 Marks P.W.... Kwiatkowski D.J. (J. Cell Sci. 1998)
    2. Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2). (PubMed id 12034507)1, 2, 3 Tumer Z.... Schreiber S. (Gene 2002)
    3. Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements. (PubMed id 15096633)1, 2, 9 Vermeulen W.... Borremans F.A. (Protein Sci. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PubMed id 18022635)1, 9 Piana S....Martins J.C. (J. Mol. Biol. 2008)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. Functional genomic screen for modulators of ciliogenesis and cilium length. (PubMed id 20393563)2 Kim J.... Gleeson J.G. (Nature 2010)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10677 HGNC: 14188 AceView: AVIL Ensembl:ENSG00000135407 euGenes: HUgn10677
    ECgene: AVIL H-InvDB: AVIL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AVIL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AVIL gene:
    Search GeneIP for patents involving AVIL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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