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Aliases & Descriptions for AVIL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ADVIL 1, 2 | | DKFZp779O1812 2 | | DOC6 1, 2 | | FLJ12386 1, 2 | | MGC133244 2 | | advillin 2 | | p92 1, 2, 3 |
| | |
| | Search outside databases for aliases for AVIL genePrevious GC identifers: GC12M057793 GC12M058334 GC12M057907 |
Summaries for AVIL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AVIL: The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq] UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366Function: Ca(2+)-regulated actin-binding protein |
Genomic Location for AVIL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AVIL gene 
Entrez Gene cytogenetic band: 12q14.1 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13.11AVIL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M056477:
(about GC identifiers)
Start:
|
56,477,704 bp from pter |
End:
|
56,496,119 bp from pter |
Size:
|
18,416 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for AVIL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366 (See
protein sequence)Recommended Name: Advillin Size: 819 amino acids; 92028 Da
Subcellular location: Cytoplasm, cytoskeleton
PDB structures from and Proteopedia :1UND (3D)
 
Secondary accessions: B2RAU7 Q2NKM9Alternative splicing: 2 isoforms: O75366-1 O75366-2 REFSEQ proteins: NP_006567.2
ENSEMBL proteins: ENSP00000257861
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AVIL: Assays for AVIL: | Protein
Domains/ Families for AVIL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75366
ProtoNet protein and cluster: O75366 3 Blocks protein families: IPB003128 Villin headpiece IPB007122 Gelsolin family signature IPB007123 Gelsolin region
UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366Similarity: Belongs to the villin/gelsolin familySimilarity: Contains 6 gelsolin-like repeatsSimilarity: Contains 1 HP (headpiece) domain | Gene Function for AVIL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006576
Applied Biosystems Silencer® siRNAs for AVIL
Sigma-Aldrich siRNA for AVIL  Sigma-Aldrich shRNA for AVIL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006576                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006576                                  untagged cDNA clone in CMV expression vector: NM_006576 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006576
UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366Function: Ca(2+)-regulated actin-binding protein3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Avil):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AVIL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5 Interacting proteins for AVIL (ENSP000002578613) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for AVIL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AVIL
|
Transcripts for AVIL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006576
Sigma-Aldrich siRNA for AVIL  Sigma-Aldrich shRNA for AVIL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006576 REFSEQ mRNAs for AVIL gene: NM_006576.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006576               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006576                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006576                                  untagged cDNA clone in CMV expression vector: NM_006576  Additional cDNA sequence: AF041449.1 AF318328.1 AK022448.1 AK314362.1 BC111730.1 BX647344.1 14 DOTS entries: DT.112342 DT.455328 DT.97868569 DT.121200921 DT.101961055 DT.40250470 DT.421093 DT.211446 DT.437665 DT.100045490 DT.40256148 DT.40120459 DT.70100979 DT.91737169 24/66 AceView cDNA sequences (see all 66
):BX647344 AI458701 BM713863 BE139483 AI215450 AI288722 F04173 BQ893208 BM510486 F02365 CA848547 AA410634 AI458294 NM_006576 AI050859 AA427733 AA534371 AA434298 AW410212 AU122557 AW081692 AK022448 BU617924 AA034150
highest scoring ESTs for AVIL:AF041449 AA098885 AI928739 BF309064 BG433816 BI114542 NM_006576 AA034149 AA075612 AA173779 Unigene Cluster for AVIL: Advillin Hs.584854 [show with all ESTs]Unigene Representative Sequence: BX647344
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for AVIL
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |
| SP3: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   |
| ExUns: | 20a | · | 20b | · | 20c | |
| SP1: | |   | |   | |   | |
| SP2: | |   | |   | |   | |
| SP3: | |   | |   | |   | |
| SP4: | |   | |   | |   | |
| SP5: | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AVIL
1 Ensembl transcript including schematic representation: ENST00000257861
|
Expression for AVIL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AVIL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AVIL
1 / 2 / 3 7 probe-sets matching AVIL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTCTCCATTT
SOURCE GeneReport for Unigene cluster: Hs.584854
Expression variation in blood from EXPOLDB for AVIL UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366Tissue specificity: Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus |
Orthologs for AVIL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AVIL gene from 5/9 species (see all 9
)
About this table Species with no ortholog for AVIL
ENSEMBL Gene Tree for AVIL | Paralogs for AVIL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AVIL gene
- VIL12
|
SNPs/Variants for AVIL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AVIL (up to first 250kb)
|
Disorders & Mutations for AVIL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for AVIL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AVIL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for AVIL gene (see all 15
):- Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins. (PubMed id 9664034)1, 2, 3, 4 Marks P.W.... Kwiatkowski D.J. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2). (PubMed id 12034507)2, 3 Tumer Z....Schreiber S. (2002)
- Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PubMed id 18022635)1, 3 Piana S....Martins J.C. (2008)
- Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements. (PubMed id 15096633)1, 3 Vermeulen W....Borremans F.A. (2004)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)4 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion. (PubMed id 11287316)3 Takami M....Petruzzelli L. (2001)
- Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth. (PubMed id 15247299)1 Shibata M....Arai H. (2004)
|
Search for AVIL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AVIL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AVIL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AVIL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AVIL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AVIL:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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