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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AVIL Gene

protein-coding GIFtS: 52
GCID: GC12M058191

advillin

Explore 10 diseases affiliated with
AVIL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Advillin¹
P92¹
ADVIL¹ ²
DOC6¹ ²
FLJ12386¹

External Ids:	HGNC: 14188¹	Entrez Gene: 10677²	Ensembl: ENSG00000135407⁷	OMIM: 613397⁵	UniProtKB: O75366³

Export aliases for AVIL gene to outside databases

Previous GC identifers: GC12M057793 GC12M058334 GC12M057907 GC12M056477 GC12M055228

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AVIL:

The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein

has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form

ganglia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366

Function: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells

which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative

sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long

fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AVIL gene promoter:
HFH-3 Egr-3 AML1a HOXA3 Ik-3 E47 HEN1 FOXI1 MEF-2A aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AVIL promoter sequence

Search SABiosciences Chromatin IP Primers for AVIL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AVIL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13.11

AVIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVIL gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M058191: view genomic region (about GC identifiers)

Start:	58,191,159 bp from pter	End:	58,212,487 bp from pter
Size:	21,329 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366 (See protein sequence)

Recommended Name: Advillin

Size: 819 amino acids; 92027 Da

Subunit: Associates (via C-terminus) with actin. Interacts with SCARF1 (By similarity). Interacts with F-actin

Subcellular location: Cytoplasm, cytoskeleton. Cell projection (By similarity). Cell projection, axon (By similarity)

1 PDB 3D structure from and Proteopedia for AVIL:

1UND (3D)

Secondary accessions: B2RAU7 Q2NKM9

Alternative splicing: 2 isoforms: O75366-1 O75366-2

Explore the universe of human proteins at neXtProt for AVIL: NX_O75366

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75366

AVIL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006567.3

ENSEMBL proteins:

ENSP00000450188 ENSP00000257861 ENSP00000449239 ENSP00000443207

Human Recombinant Protein Products for AVIL:

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	Novus Biologicals AVIL Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AVIL

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0015629	actin cytoskeleton	TAS	9664034
GO:0030424	axon	IEA	--
GO:0042995	cell projection	ISS	--
GO:0043005	neuron projection	ISS	--

AVIL for ontologies About GeneDecksing

AVIL Antibody Products:

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	Uscn Antibodies for AVIL
	ThermoFisher Antibody for AVIL

Assay Products for AVIL:

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	Uscn ELISAs and CLIAs for AVIL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AVIL for domains About GeneDecksing

4 InterPro domains/families:

IPR015627 Villin

IPR007122 Gelsolin

IPR003128 Villin_headpiece

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry O75366

ProtoNet protein and cluster: O75366

3 Blocks protein families:

IPB003128 Villin headpiece

IPB007122 Gelsolin family signature

IPB007123 Gelsolin region

UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366

Similarity: Belongs to the villin/gelsolin family

Similarity: Contains 6 gelsolin-like repeats

Similarity: Contains 1 HP (headpiece) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AVIL_HUMAN, O75366

Function: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells

which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative

sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long

fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	ISS	--
GO:0005515	protein binding	--	--

AVIL for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for AVIL:

Decreased cilium length

Decreased cilium length after

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Avil):

behavior/neurological	cellular	integument	limbs/digits/tail	mortality/aging
nervous system	no phenotypic analysis

AVIL for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AVIL

miRNA Products:		OriGene 3'-UTR Clone: AVIL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AVIL
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate AVIL:
		hsa-miR-1290 hsa-miR-520f hsa-miR-562 hsa-miR-3143 hsa-miR-1271 hsa-miR-96
		SwitchGear 3'UTR luciferase reporter plasmid: AVIL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AVIL (see all 7) OriGene shRNA RFP: AVIL OriGene siRNA: AVIL
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		Sirion Biotech Custom design and validation of potent shRNA sequences against AVIL

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for AVIL
			Sirion Biotech Customized adenovirus for overexpression of AVIL Sirion Biotech Customized adenovirus for potent knockdown of AVIL

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AVIL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AVIL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVIL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AVIL

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for AVIL (O75366³ ENSP00000257861⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRK	P46108³, ENSP00000300574⁴	I2D: score=1 STRING: ENSP00000300574
HDAC8	ENSP00000362674⁴	STRING: ENSP00000362674

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006950	response to stress	IEA	--
GO:0007010	cytoskeleton organization	IEA	--
GO:0007399	nervous system development	TAS	9664034
GO:0010976	positive regulation of neuron projection development	ISS	--
GO:0051693	actin filament capping	IEA	--

AVIL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AVIL
Search CenterWatch for drugs/clinical trials and news about AVIL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AVIL gene:

NM_006576.3

Unigene Cluster for AVIL:

Advillin

Hs.584854 [show with all ESTs]

Unigene Representative Sequence: NM_006576

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000546952 ENST00000549851 ENST00000551248 ENST00000257861 ENST00000550537(uc001sqk.1)

ENST00000550083 ENST00000549548 ENST00000549753 ENST00000548843(uc001sql.4)

ENST00000549994 ENST00000537081(uc001sqj.2 uc009zqe.2)

miRNA Products:		OriGene 3'-UTR Clone: AVIL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AVIL
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate AVIL:
		hsa-miR-1290 hsa-miR-520f hsa-miR-562 hsa-miR-3143 hsa-miR-1271 hsa-miR-96
		SwitchGear 3'UTR luciferase reporter plasmid: AVIL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AVIL (see all 7) OriGene shRNA RFP: AVIL OriGene siRNA: AVIL
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		Sirion Biotech Custom design and validation of potent shRNA sequences against AVIL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AVIL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AVIL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AVIL (NM_006576)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVIL
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AVIL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat AVIL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AVIL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AVIL

Additional cDNA sequence:

AF041449.1 AF318328.1 AK022448.1 AK314362.1 BX647344.1 XR_159030.2 XR_159219.2 XR_171957.1

13 DOTS entries:

DT.112342 DT.455328 DT.97868569 DT.121200921 DT.101961055 DT.421093 DT.40250470 DT.437665

DT.100045490 DT.40256148 DT.211446 DT.40120459 DT.70100979

24/66 AceView cDNA sequences (see all 66):

BM510486 AI050859 F04173 BQ893208 AW410212 AI458701 CA848547 BX647344

AI288722 AI215450 AI458294 BE139483 BM713863 NM_006576 AA434298 F02365

AA534371 AA410634 AA427733 BM511317 BQ720945 AF041449 CA848258 AA034149

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for AVIL About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b	^
SP1:																					-														-										-				-
SP2:																																			-								-		-		-
SP3:			-
SP4:
SP5:																																																	-

ExUns:	20a	·	20b	·	20c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for AVIL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AVIL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTCCATTT

About this image

AVIL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AVIL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AVIL

SOURCE GeneReport for Unigene cluster: Hs.584854

UniProtKB/Swiss-Prot: AVIL_HUMAN, O75366

Tissue specificity: Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in

the thymus, prostate, testes and uterus

SABiosciences Custom PCR Arrays for AVIL

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AVIL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVIL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AVIL gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	AVIL⁶	--	71(a)	1 ↔ 1	2(66980914-67021231)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.5242²	Transcribed sequence with weak similarity to protein more	76.41(n)		137723683
zebrafish (Danio rerio)	Actinopterygii	zgc:136857¹	zgc:136857	65.92(n) 64.81(a)		678618 NM_001040365.1 NP_001035455.1
fruit fly (Drosophila melanogaster)	Insecta	Gel³	actin binding	37(a)		82A1 --
worm (Caenorhabditis elegans)	Secernentea	K06A4.3³	gelsolin	34(a)		V(9499695-9501863) --
thale cress (Arabidopsis thaliana)	eudicotyledons	VLN3⁶ VLN2⁶ (see all 5)	villin 2 (see all 5)	27(a) 27(a) (see all 5)	possible ortholog possible ortholog (see all 5)	3(21243136-21251100) 2(17410715-17417740)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	villin protein, putative, expressed (see all 5)	28(a) 26(a) (see all 5)	possible ortholog possible ortholog (see all 5)	8(8507453-8515439) 4(30278742-30287878)

ENSEMBL Gene Tree for AVIL (if available)
TreeFam Gene Tree for AVIL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AVIL gene

SVIL² FLII² VILL² SCIN² GSN² VIL1² CAPG²

8 SIMAP similar genes for AVIL using alignment to 3 protein entries: AVIL_HUMAN (see all proteins):

VIL1 DKFZp313L0718 VILL GSN SVIL SCIN

CAPG FLII

AVIL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55933151^1,2	C	--	55248470(+)	`CCCGTT/CTCCCA`	1	--	ds500¹		2		NA	122
rs11172348^1,2	C,F,H	--	55248616(+)	`TCTCTC/TCTTCT`	1	--	nc-transcript-varianttrp³		18		NS EA NA WA CSA	1744
rs147036496^1,2	C	--	58197143(+)	`GAGACG/AAGACT`	2	/R /C	mis¹		1		NA	4552
rs201495811^1,2		--	58197169(+)	`CCTGCC/TGAAGT`	2	Q R	mis¹		0	--	--	--	--
rs189660976^1,2	C	--	58197180(+)	`CTGCAA/GTATAG`	1	--	int¹		0	--	--	--	--
rs193038207^1,2	C,F	--	58197182(+)	`GCAATA/GTAGTC`	1	--	int¹		1		EU	1323
rs60780489^1,2	C	--	58197231(+)	`ACTGAG/TGTTTT`	1	--	int¹		2		EA EU	713
rs200519392^1,2		--	58197323(+)	`GGCATA/GGGGAG`	2	H Y	mis¹		0	--	--	--	--
rs142606117^1,2	C,F	--	58197363(+)	`GCTGGC/TTCCTG`	2	E	syn¹		2		NA EU	5813
rs199694346^1,2		--	58197434(+)	`TGCCCA/GCTCAT`	2	R W	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AVIL (58191159 - 58212487 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AVIL: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AVIL

DNA2.0 Custom Variant and Variant Library Synthesis for AVIL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AVIL for disorders           About GeneDecksing

OMIM gene information: 613397    OMIM disorders: --

10 diseases for AVIL:    About MalaCards

petit mal status lennox-gastaut syndrome inflammatory bowel disease 12 dengue hemorrhagic fever

inflammatory bowel disease dengue shock syndrome dacryoadenitis hemorrhagic fever

neuronitis prostatitis

1 disease from the University of Copenhagen DISEASES database for AVIL:

Lennox-Gastaut syndrome

Export disorders for AVIL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AVIL gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with AVIL)

Utopia: connect your pdf to the dynamic
world of online information

Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins. (PubMed id 9664034)^{1, 2, 3, 9} Marks P.W.... Kwiatkowski D.J. (1998)
Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2). (PubMed id 12034507)^{1, 2, 3} Tumer Z....Schreiber S. (2002)
Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements. (PubMed id 15096633)^{1, 2, 9} Vermeulen W....Borremans F.A. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PubMed id 18022635)^{1, 9} Piana S....Martins J.C. (2008)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Functional genomic screen for modulators of ciliogenesis and cilium length. (PubMed id 20393563)² Kim J.... Gleeson J.G. (2010)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10677	HGNC: 14188	AceView: AVIL	Ensembl:ENSG00000135407	euGenes: HUgn10677
ECgene: AVIL	H-InvDB: AVIL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AVIL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AVIL gene
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Patent Information for AVIL gene:
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GeneCards and IP:
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