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AVEN Gene

protein-coding   GIFtS: 54
GCID: GC15M034158

Apoptosis, Caspase Activation Inhibitor

  See AVEN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apoptosis, Caspase Activation Inhibitor1 2
Cell Death Regulator Aven1 2
Programmed Cell Death 121 2
PDCD122

External Ids:    HGNC: 135091   Entrez Gene: 570992   Ensembl: ENSG000001698577   OMIM: 6052655   UniProtKB: Q9NQS13   

Export aliases for AVEN gene to outside databases

Previous GC identifers: GC15M029400 GC15M026866 GC15M031737 GC15M031874 GC15M031945 GC15M011021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AVEN Gene:
AVEN (apoptosis, caspase activation inhibitor) is a protein-coding gene. Diseases associated with AVEN include schizoid personality disorder, and alexithymia.

UniProtKB/Swiss-Prot: AVEN_HUMAN, Q9NQS1
Function: Protects against apoptosis mediated by Apaf-1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AVEN gene promoter:
         STAT5B   Elk-1   NRF-2   NCX/Ncx   STAT5A   Nkx2-5   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AVEN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AVEN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.1   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q13.1

AVEN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVEN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M034158:  view genomic region     (about GC identifiers)

Start:
34,158,428 bp from pter      End:
34,331,377 bp from pter
Size:
172,950 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AVEN_HUMAN, Q9NQS1 (See protein sequence)
Recommended Name: Cell death regulator Aven  
Size: 362 amino acids; 38506 Da
Subunit: Binds Apaf-1, BCL-2 and BAD (Bcl-xl)

Explore the universe of human proteins at neXtProt for AVEN: NX_Q9NQS1

Explore proteomics data for AVEN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AVEN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065104.1  
    ENSEMBL proteins: 
     ENSP00000306822   ENSP00000452906  

    AVEN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for AVEN
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    Novus Biologicals AVEN Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AVEN

     
    Search eBioscience for Proteins for AVEN 

    AVEN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for AVEN 
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    OriGene Custom Antibody Services for AVEN
    Novus Biologicals AVEN Antibodies
    Abcam antibodies for AVEN
    Cloud-Clone Corp. Antibodies for AVEN
    ThermoFisher Antibodies for AVEN
    LSBio Antibodies in human, mouse, rat for AVEN

    AVEN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for AVEN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AVEN
    Cloud-Clone Corp. CLIAs for AVEN
    Search eBioscience for ELISAs for AVEN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026187 Aven

    Graphical View of Domain Structure for InterPro Entry Q9NQS1

    ProtoNet protein and cluster: Q9NQS1


    Find genes that share domains with AVEN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AVEN_HUMAN, Q9NQS1
    Function: Protects against apoptosis mediated by Apaf-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10949025
         
    Find genes that share ontologies with AVEN           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aven):
     cellular 

    Find genes that share phenotypes with AVEN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AVEN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AVEN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AVEN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AVEN

    miRNA
    Products:
        
    miRTarBase miRNAs that target AVEN:
    hsa-mir-124-3p (MIRT022196), hsa-mir-98-5p (MIRT027461), hsa-mir-30a-5p (MIRT007276)

    Block miRNA regulation of human, mouse, rat AVEN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AVEN (see all 15):
    hsa-miR-30c hsa-miR-98 hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidAVEN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AVEN
    Predesigned siRNA for gene silencing in human, mouse, rat AVEN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AVEN

    Clone
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    OriGene clones in human, mouse for AVEN (see all 8)
    OriGene ORF clones in mouse, rat for AVEN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AVEN (NM_020371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVEN

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for AVEN
    Browse ESI BIO Cell Lines and PureStem Progenitors for AVEN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVEN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AVEN_HUMAN, Q9NQS1: Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular
    membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10949025
    GO:0012505endomembrane system IEA--
    GO:0016020membrane IDA10949025

    Find genes that share ontologies with AVEN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AVEN About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with AVEN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AVEN
        Apoptosis and Autophagy


        Pathway & Disease-focused RT2 Profiler PCR Arrays including AVEN: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AVEN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for AVEN (Q9NQS12, 3 ENSP000003068224) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APAF1O147272, 3, ENSP000003530594MINT-17186 MINT-17187 I2D: score=3 STRING: ENSP00000353059
    BCL2L1Q078173, ENSP000003025644I2D: score=2 STRING: ENSP00000302564
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    BCL2P104153, ENSP000003296234I2D: score=1 STRING: ENSP00000329623
    AXIN2Q9Y2T13I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process IDA10949025

    Find genes that share ontologies with AVEN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AVEN

    1 Novoseek inferred chemical compound relationship for AVEN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thapsigargin 35 2 11276013 (2)



    Find genes that share compounds with AVEN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AVEN gene: 
    NM_020371.2  

    Unigene Cluster for AVEN:

    Apoptosis, caspase activation inhibitor
    Hs.555966  [show with all ESTs]
    Unigene Representative Sequence: NM_020371
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306730(uc001zhj.3) ENST00000560649 ENST00000558136
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AVEN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AVEN (see all 15):
    hsa-miR-30c hsa-miR-98 hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidAVEN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AVEN
    Predesigned siRNA for gene silencing in human, mouse, rat AVEN
    Clone
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    OriGene clones in human, mouse for AVEN (see all 8)
    OriGene ORF clones in mouse, rat for AVEN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AVEN (NM_020371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVEN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AVEN
    OriGene qSTAR qPCR primer pairs in human, mouse for AVEN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AVEN
      QuantiTect SYBR Green Assays in human, mouse, rat AVEN
      QuantiFast Probe-based Assays in human, mouse, rat AVEN

    Additional mRNA sequence: 

    AF283508.1 AK025888.1 BC010488.1 BC063533.1 

    2 DOTS entries:

    DT.410128  DT.409791 

    Selected AceView cDNA sequences (see all 69):

    CR618548 AL541314 CR619789 BC010488 AI373132 AI473327 BU620526 AA630591 
    BM680720 BM711332 BC063533 BG285015 BM665905 BX090037 BM807941 AI018614 
    AA947847 NM_020371 AF283508 BM811419 BU856249 AW673669 BM760540 AI804357 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AVEN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTGGCCA
    AVEN Expression
    About this image


    AVEN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    AVEN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AVEN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555966

    UniProtKB/Swiss-Prot: AVEN_HUMAN, Q9NQS1
    Tissue specificity: Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart,
    skeletal muscle, liver, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AVEN: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AVEN
    OriGene qSTAR qPCR primer pairs in human, mouse for AVEN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AVEN
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    QuantiFast Probe-based Assays in human, mouse, rat AVEN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVEN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AVEN gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aven1 , 5 apoptosis, caspase activation inhibitor1, 5 80.51(n)1
    73.65(a)1
      2 (57.04 cM)5
    742681  NM_028844.31  NP_083120.21 
     1124929645 
    chicken
    (Gallus gallus)
    Aves AVEN1 apoptosis, caspase activation inhibitor 59.15(n)
    53.01(a)
      395127  NM_001005791.1  NP_001005791.1 
    lizard
    (Anolis carolinensis)
    Reptilia AVEN6
    apoptosis, caspase activation inhibitor
    42(a)
    1 ↔ 1
    1(33513060-33655519)
    zebrafish
    (Danio rerio)
    Actinopterygii aven6
    apoptosis, caspase activation inhibitor
    37(a)
    1 ↔ 1
    20(29257464-29295270) ENSDARG00000002894


    ENSEMBL Gene Tree for AVEN (if available)
    TreeFam Gene Tree for AVEN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AVEN (see all 2664)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573921611,2
    C--14263214(+) CATTAGGT/-GATTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2009388951,2
    --34158886(+) TGCTCA/GGGTTC 2 P syn10--------
    rs1476798131,2
    C,F--34158888(+) CTCAGG/CTTCCA 2 /P /A mis12Minor allele frequency- C:0.00NA EU 5869
    rs1423180411,2
    C--34158896(+) CCATGT/ATTTTT 2 /N /I mis11Minor allele frequency- A:0.00NA 4544
    rs1864102421,2
    C--34158902(+) TTTTTC/TCTTCA 2 E G mis10--------
    rs1469072961,2
    C--34158923(+) GTTTTG/ACACAA 2 /A /V mis11Minor allele frequency- A:0.00NA 4544
    rs1996188871,2
    --34158931(+) CAAACC/TGGGGG 1 -- spa10--------
    rs1469386401,2
    C--34158962(+) CCTCAA/GATGAG 1 -- int10--------
    rs1177033721,2
    C,F--34158981(+) TTGAAG/CGTATA 1 -- int12Minor allele frequency- C:0.04NA EU 713
    rs1379046971,2
    --34159091(+) GTAGAC/GGATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for AVEN (34158428 - 34331377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AVEN (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4730CNV Deletion18987735
    esv2749546CNV Deletion23290073
    esv2661499CNV Deletion23128226
    esv2678803CNV Deletion23128226
    esv1207147CNV Insertion17803354
    nsv507771CNV Insertion20534489
    nsv513427CNV Insertion21212237
    esv2648750CNV Insertion19546169
    esv24590CNV Loss19812545
    nsv516347CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AVEN
    DNA2.0 Custom Variant and Variant Library Synthesis for AVEN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605265    OMIM disorders: --

    2 diseases for AVEN:    
    About MalaCards
    schizoid personality disorder    alexithymia

    2 diseases from the University of Copenhagen DISEASES database for AVEN:
    Schizoid personality disorder     Alexithymia

    Find genes that share disorders with AVEN           About GenesLikeMe

    2 Novoseek inferred disease relationships for AVEN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15156195 (1), 17592138 (1), 15540893 (1)
    cancer 0 1 17592138 (1)

    Genetic Association Database (GAD): AVEN
    Human Genome Epidemiology (HuGE) Navigator: AVEN (8 documents)

    Export disorders for AVEN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AVEN gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with AVEN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf- 1. (PubMed id 10949025)1, 2, 3 Chau B.N.... Hardwick J.M. (Mol. Cell 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    7. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4 Kitahara K....Ota M. (Dis. Markers 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. (PubMed id 22751129)1 EiA9mann M....ZAPrnig M. (Oncogene 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57099 HGNC: 13509 AceView: AVEN Ensembl:ENSG00000169857 euGenes: HUgn57099
    ECgene: AVEN H-InvDB: AVEN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AVEN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AVEN gene:
    Search GeneIP for patents involving AVEN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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