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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AVEN Gene

protein-coding   GIFtS: 54
GCID: GC15M034158

Apoptosis, Caspase Activation Inhibitor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apoptosis, Caspase Activation Inhibitor1 2
Cell Death Regulator Aven1 2
Programmed Cell Death 121 2
PDCD122

External Ids:    HGNC: 135091   Entrez Gene: 570992   Ensembl: ENSG000001698577   OMIM: 6052655   UniProtKB: Q9NQS13   

Export aliases for AVEN gene to outside databases

Previous GC identifers: GC15M029400 GC15M026866 GC15M031737 GC15M031874 GC15M031945 GC15M011021


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AVEN Gene: 
AVEN (apoptosis, caspase activation inhibitor) is a protein-coding gene. Diseases associated with AVEN include schizoid personality disorder, and alexithymia. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: AVEN_HUMAN, Q9NQS1
Function: Protects against apoptosis mediated by Apaf-1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AVEN gene promoter:
         STAT5B   Elk-1   NRF-2   NCX/Ncx   STAT5A   Nkx2-5   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for AVEN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AVEN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.1   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q13.1

AVEN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AVEN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M034158:  view genomic region     (about GC identifiers)

Start:
34,158,428 bp from pter      End:
34,331,377 bp from pter
Size:
172,950 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AVEN_HUMAN, Q9NQS1 (See protein sequence)
Recommended Name: Cell death regulator Aven  
Size: 362 amino acids; 38506 Da
Subunit: Binds Apaf-1, BCL-2 and BAD (Bcl-xl)
Subcellular location: Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular
membranes

Explore the universe of human proteins at neXtProt for AVEN: NX_Q9NQS1

Explore proteomics data for AVEN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQS1

  • AVEN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AVEN Protein Expression
    REFSEQ proteins: NP_065104.1  
    ENSEMBL proteins: 
     ENSP00000306822   ENSP00000452906  

    Human Recombinant Protein Products for AVEN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for AVEN 
    OriGene Custom Protein Services for AVEN
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    Novus Biologicals AVEN Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AVEN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10949025
    GO:0012505endomembrane system IEA--
    GO:0016020membrane IDA10949025

    AVEN for ontologies           About GeneDecksing



    AVEN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AVEN
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    Abcam antibodies for AVEN
    Cloud-Clone Corp. Antibodies for AVEN 
    ThermoFisher Antibodies for AVEN
    LSBio Antibodies in human, mouse, rat for AVEN 

    Assay Products for AVEN: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AVEN 
    Cloud-Clone Corp. CLIAs for AVEN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026187 Aven

    Graphical View of Domain Structure for InterPro Entry Q9NQS1

    ProtoNet protein and cluster: Q9NQS1


    AVEN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AVEN_HUMAN, Q9NQS1
    Function: Protects against apoptosis mediated by Apaf-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10949025
         
    AVEN for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aven):
     cellular 

    AVEN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AVEN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AVEN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AVEN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AVEN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AVEN
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate AVEN (see all 15):
    hsa-miR-30c hsa-miR-98 hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidAVEN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AVEN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AVEN

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for AVEN
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    GenScript: all cDNA clones in your preferred vector: AVEN (NM_020371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVEN
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                         Customized lentivirus expression plasmids for stable overexpression of AVEN 

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    GenScript Custom overexpressing Cell Line Services for AVEN
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVEN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AVEN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AVEN
        Apoptosis and Autophagy



    AVEN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AVEN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/10 Interacting proteins for AVEN (Q9NQS12, 3 ENSP000003068224) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APAF1O147272, 3, ENSP000003530594MINT-17186 MINT-17187 I2D: score=3 STRING: ENSP00000353059
    BCL2L1Q078173, ENSP000003025644I2D: score=2 STRING: ENSP00000302564
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    BCL2P104153, ENSP000003296234I2D: score=1 STRING: ENSP00000329623
    AXIN2Q9Y2T13I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process IDA10949025

    AVEN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AVEN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AVEN

    1 Novoseek inferred chemical compound relationship for AVEN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thapsigargin 35 2 11276013 (2)

    Search CenterWatch for drugs/clinical trials and news about AVEN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AVEN gene: 
    NM_020371.2  

    Unigene Cluster for AVEN:

    Apoptosis, caspase activation inhibitor
    Hs.555966  [show with all ESTs]
    Unigene Representative Sequence: NM_020371
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306730(uc001zhj.3) ENST00000560649 ENST00000558136
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AVEN
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate AVEN (see all 15):
    hsa-miR-30c hsa-miR-98 hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7i hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidAVEN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AVEN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AVEN
    Clone
    Products:
         
    OriGene clones in human, mouse for AVEN (see all 9)
    OriGene ORF clones in mouse, rat for AVEN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AVEN (NM_020371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AVEN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AVEN
    Sirion Biotech Customized lentivirus for stable overexpression of AVEN 
                         Customized lentivirus expression plasmids for stable overexpression of AVEN 
    Primer
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    OriGene qPCR primer pairs and template standards for AVEN
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AVEN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AVEN

    Additional mRNA sequence: 

    AF283508.1 AK025888.1 BC010488.1 BC063533.1 

    2 DOTS entries:

    DT.410128  DT.409791 

    24/69 AceView cDNA sequences (see all 69):

    AI373132 AI473327 BU620526 AA630591 BM680720 BM711332 BC063533 BG285015 
    BM665905 BX090037 BM807941 AI018614 CR619789 AL541314 CR618548 BC010488 
    AI804357 BM762814 AW969599 BM796145 BM843171 AK025888 AA678956 BU855198 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AVEN expression in normal human tissues (normalized intensities)      AVEN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTGGCCA
    AVEN Expression
    About this image


    AVEN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             optic nerve head astrocytes   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             cervix, uterine ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See AVEN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AVEN

    SOURCE GeneReport for Unigene cluster: Hs.555966

    UniProtKB/Swiss-Prot: AVEN_HUMAN, Q9NQS1
    Tissue specificity: Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart,
    skeletal muscle, liver, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including AVEN: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AVEN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AVEN gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aven1 , 5 apoptosis, caspase activation inhibitor1, 5 80.02(n)1
    75.44(a)1
      2 (57.04 cM)5
    742681  NM_028844.31  NP_083120.21 
     1124929645 
    chicken
    (Gallus gallus)
    Aves AVEN1 apoptosis, caspase activation inhibitor 60.21(n)
    52.6(a)
      395127  NM_001005791.1  NP_001005791.1 
    lizard
    (Anolis carolinensis)
    Reptilia AVEN6
    apoptosis, caspase activation inhibitor
    39(a)
    1 ↔ 1
    1(33513060-33655519)
    zebrafish
    (Danio rerio)
    Actinopterygii aven1 apoptosis, caspase activation inhibitor 52.32(n)
    44.04(a)
      692323  NM_001045292.2  NP_001038757.2 


    ENSEMBL Gene Tree for AVEN (if available)
    TreeFam Gene Tree for AVEN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2664 SNPs in AVEN are shown (see all 2664)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573921611,2
    C--14263214(+) CATTAGGT/-GATTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2009388951,2
    --34158886(+) TGCTCA/GGGTTC 2 P syn10--------
    rs1476798131,2
    C,F--34158888(+) CTCAGG/CTTCCA 2 /P /A mis12Minor allele frequency- C:0.00NA EU 5869
    rs1423180411,2
    C--34158896(+) CCATGT/ATTTTT 2 /N /I mis11Minor allele frequency- A:0.00NA 4544
    rs1864102421,2
    C--34158902(+) TTTTTC/TCTTCA 2 E G mis10--------
    rs1469072961,2
    C--34158923(+) GTTTTG/ACACAA 2 /A /V mis11Minor allele frequency- A:0.00NA 4544
    rs1996188871,2
    --34158931(+) CAAACC/TGGGGG 1 -- spa10--------
    rs1469386401,2
    C--34158962(+) CCTCAA/GATGAG 1 -- int10--------
    rs1177033721,2
    C,F--34158981(+) TTGAAG/CGTATA 1 -- int12Minor allele frequency- C:0.04NA EU 713
    rs1379046971,2
    --34159091(+) GTAGAC/GGATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for AVEN (34158428 - 34331377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for AVEN (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv4730CNV Deletion18987735
    esv2749546CNV Deletion23290073
    esv2661499CNV Deletion23128226
    esv2678803CNV Deletion23128226
    esv1207147CNV Insertion17803354
    nsv507771CNV Insertion20534489
    nsv513427CNV Insertion21212237
    esv2648750CNV Insertion19546169
    esv24590CNV Loss19812545
    nsv516347CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AVEN
    DNA2.0 Custom Variant and Variant Library Synthesis for AVEN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605265    OMIM disorders: --

    18 diseases for AVEN:    About MalaCards
    schizoid personality disorder    alexithymia    glucocorticoid resistance    personality disorder
    malignant pleural mesothelioma    prader-willi syndrome    kaposi's sarcoma    acute lymphoblastic leukemia
    lymphoblastic leukemia    sarcoma    alcoholism    myeloid leukemia
    leukemia    alzheimer's disease    prostate cancer    prostatitis
    pancreatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for AVEN:
    Schizoid personality disorder     Alexithymia

    AVEN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for AVEN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15156195 (1), 17592138 (1), 15540893 (1)
    cancer 0 1 17592138 (1)

    Genetic Association Database (GAD): AVEN
    Human Genome Epidemiology (HuGE) Navigator: AVEN (8 documents)

    Export disorders for AVEN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AVEN gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with AVEN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf- 1. (PubMed id 10949025)1, 2, 3 Chau B.N.... Hardwick J.M. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. (2009)
    7. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4 Kitahara K....Ota M. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Overexpression of the anti-apoptotic protein AVEN cont ributes to increased malignancy in hematopoietic neoplasms. (PubMed id 22751129)1 Eismann M....Zornig M. (2013)
    10. The Apaf-1-binding protein Aven is cleaved by Cathepsi n D to unleash its anti-apoptotic potential. (PubMed id 22388353)1 Melzer I.M....Zornig M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57099 HGNC: 13509 AceView: AVEN Ensembl:ENSG00000169857 euGenes: HUgn57099
    ECgene: AVEN H-InvDB: AVEN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AVEN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AVEN gene:
    Search GeneIP for patents involving AVEN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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