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Aliases for AURKC Gene

Aliases for AURKC Gene

  • Aurora Kinase C 2 3
  • STK13 3 4 6
  • AIE2 3 4 6
  • Serine/Threonine Kinase 13 (Aurora/IPL1-Like) 2 3
  • Serine/Threonine-Protein Kinase Aurora-C 3 4
  • Serine/Threonine-Protein Kinase 13 3 4
  • Aurora/IPL1-Related Kinase 3 3 4
  • Aurora-Related Kinase 3 3 4
  • EC 2.7.11.1 4 64
  • Aurora 3 3 4
  • SPGF5 3 6
  • ARK-3 3 4
  • AIK3 3 4
  • ARK3 3 4
  • Aurora/IPL1/EG2 Protein 2 3
  • Aurora/IPL1/Eg2 Protein 2 4
  • EC 2.7.11 64
  • Aurora-C 3
  • AIRK3 4
  • AurC 3

External Ids for AURKC Gene

Previous Symbols for AURKC Gene

  • STK13

Summaries for AURKC Gene

Entrez Gene Summary for AURKC Gene

  • This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for AURKC Gene

AURKC (Aurora Kinase C) is a Protein Coding gene. Diseases associated with AURKC include spermatogenic failure 5 and macrozoospermia. Among its related pathways are ERK Signaling and Cell Cycle / Checkpoint Control. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is AURKB.

UniProtKB/Swiss-Prot for AURKC Gene

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at Ser-10 and Ser-28. Phosphorylates TACC1, another protein involved in cell division, at Ser-228.

Gene Wiki entry for AURKC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKC Gene

Genomics for AURKC Gene

Genomic Location for AURKC Gene

Start:
57,230,381 bp from pter
End:
57,235,548 bp from pter
Size:
5,168 bases
Orientation:
Plus strand

Genomic View for AURKC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AURKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKC Gene

Regulatory Elements for AURKC Gene

Proteins for AURKC Gene

  • Protein details for AURKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQB9-AURKC_HUMAN
    Recommended name:
    Aurora kinase C
    Protein Accession:
    Q9UQB9
    Secondary Accessions:
    • O60681
    • O75442
    • Q6AZY8
    • Q6DLZ0
    • Q9UPK5

    Protein attributes for AURKC Gene

    Size:
    309 amino acids
    Molecular mass:
    35591 Da
    Quaternary structure:
    • Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.

    Alternative splice isoforms for AURKC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AURKC Gene

Proteomics data for AURKC Gene at MOPED

Post-translational modifications for AURKC Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys53, Lys130, and Lys197

Domains for AURKC Gene

Gene Families for AURKC Gene

UniProtKB/Swiss-Prot:

AURKC_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9UQB9
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.:
    • Q9UQB9
genes like me logo Genes that share domains with AURKC: view

Function for AURKC Gene

Molecular function for AURKC Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at Ser-10 and Ser-28. Phosphorylates TACC1, another protein involved in cell division, at Ser-228.
UniProtKB/Swiss-Prot Induction: Expression is cell cycle-regulated, with an increase during G2 and M phases.

Enzyme Numbers (IUBMB) for AURKC Gene

Gene Ontology (GO) - Molecular Function for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15670791
GO:0004674 protein serine/threonine kinase activity --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with AURKC: view

Phenotypes for AURKC Gene

genes like me logo Genes that share phenotypes with AURKC: view

Animal Models for AURKC Gene

MGI Knock Outs for AURKC:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for AURKC Gene

Localization for AURKC Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKC Gene

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKC Gene COMPARTMENTS Subcellular localization image for AURKC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region --
GO:0000780 condensed nuclear chromosome, centromeric region IBA --
GO:0000793 condensed chromosome IDA 15670791
GO:0005634 nucleus --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with AURKC: view

Pathways for AURKC Gene

genes like me logo Genes that share pathways with AURKC: view

Pathways by source for AURKC Gene

2 Qiagen pathways for AURKC Gene
1 Cell Signaling Technology pathway for AURKC Gene

Gene Ontology (GO) - Biological Process for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IEA --
GO:0006468 protein phosphorylation IDA 15670791
GO:0007283 spermatogenesis IEA --
GO:0008608 attachment of spindle microtubules to kinetochore TAS 19774610
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with AURKC: view

Compounds for AURKC Gene

(28) ApexBio Compounds for AURKC Gene

Compound Action Cas Number
AMG-900 potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C [945595-80-2]
Anacardic acid selectively activate Aurora kinase A-mediated phosphorylation of histone H3 [16611-84-0]
AT9283 novel inhibitor of aurora kinase [896466-04-9]
Aurora A Inhibitor I novel, potent, and selective inhibitor of Aurora A [1158838-45-9]
AZD1152 selective Aurora B kinase inhibitor [722543-31-9]
Barasertib (AZD1152-HQPA) potent aurora kinase inhibitor [722544-51-6]
CCT129202 ATP-competitively inhibits Aurora A, Aurora B and Aurora C [942947-93-5]
CCT137690 highly selective inhibitor of Aurora A, Aurora B and Aurora C. [1095382-05-0]
CYC116 potent inhibitor of Aurora A/B. [693228-63-6]
Danusertib (PHA-739358) Pan-aurora kinase inhibitor [827318-97-8]
ENMD-2076 selective activity against Aurora A and VEGFR(Flt3). [934353-76-1]
GSK1070916 reversible and ATP-competitive inhibitor of Aurora B/C. [942918-07-2]
Hesperadin Hesperadin potently inhibits Aurora B with IC50 of 250 nM. [422513-13-1]
JNJ-7706621 dual inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases [443797-96-4]
MK-5108 (VX-689) novel, potent and selective inhibitor of Aurora A kinase. [1010085-13-8]
MK-8745 potent and selective Aurora A inhibitor. [885325-71-3]
MLN8054 potent of Aurora A kinase inhibitor [869363-13-3]
MLN8237 (Alisertib) potent small-molecule inhibitor of Aurora A kinase [1028486-01-2]
PF-03814735 novel, potent and reversible inhibitor of Aurora A/B. [942487-16-3]
PHA-680632 novel and potent inhibitor of Aurora kinases. [398493-79-3]
Reversine inhibition of Aurora A and B. [656820-32-5]
SCH-1473759 novel sub-nanomolar Aurora A/B inhibitor [1094069-99-4]
SNS-314 Mesylate potent and selective inhibitor of Aurora A, Aurora B and Aurora C. [1146618-41-8]
TAK-901 novel inhibitor of Aurora A/B. [934541-31-8]
TC-A 2317 hydrochloride Potent Aurora kinase A inhibitor [1245907-03-2]
VX-680 (MK-0457,Tozasertib) potent inhibitor of pan-aurora kinase [639089-54-6]
XL228 protein kinase inhibitor targeting AURORA kinases [898280-07-4]
ZM 447439 novel, potent and selective inhibitor of Aurora kinase [331771-20-1]

(2) HMDB Compounds for AURKC Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with AURKC: view

Transcripts for AURKC Gene

mRNA/cDNA for AURKC Gene

Unigene Clusters for AURKC Gene

Aurora kinase C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for AURKC Gene

GeneLoc Exon Structure for
AURKC
ECgene alternative splicing isoforms for
AURKC

Expression for AURKC Gene

mRNA expression in normal human tissues for AURKC Gene

mRNA differential expression in normal tissues according to GTEx for AURKC Gene

This gene is overexpressed in Testis (17.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AURKC Gene

SOURCE GeneReport for Unigene cluster for AURKC Gene Hs.98338

mRNA Expression by UniProt/SwissProt for AURKC Gene

Q9UQB9-AURKC_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
genes like me logo Genes that share expressions with AURKC: view

Orthologs for AURKC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKC 36
  • 99.24 (n)
  • 99.68 (a)
AURKC 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
LOC618599 36
  • 84.46 (n)
  • 83.78 (a)
dog
(Canis familiaris)
Mammalia AURKC 36
  • 85.51 (n)
  • 87.63 (a)
STK13 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurkc 36
  • 81.87 (n)
  • 79.56 (a)
Aurkc 16
Aurkc 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8843 36
zebrafish
(Danio rerio)
Actinopterygii aurkb 37
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007855 36
  • 56.54 (n)
  • 54.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta aur 37
  • 38 (a)
OneToMany
ial 36
  • 58.79 (n)
  • 51.97 (a)
worm
(Caenorhabditis elegans)
Secernentea air-2 37
  • 53 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 37
  • 35 (a)
OneToMany
IPL1 39
soybean
(Glycine max)
eudicotyledons Gma.9652 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AUR3 36
  • 57.28 (n)
  • 57.41 (a)
corn
(Zea mays)
Liliopsida Zm.17459 36
rice
(Oryza sativa)
Liliopsida Os03g0765000 36
  • 57.48 (n)
  • 57.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 37
  • 59 (a)
OneToMany
Species with no ortholog for AURKC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AURKC Gene

ENSEMBL:
Gene Tree for AURKC (if available)
TreeFam:
Gene Tree for AURKC (if available)

Paralogs for AURKC Gene

Paralogs for AURKC Gene

genes like me logo Genes that share paralogs with AURKC: view

Variants for AURKC Gene

Sequence variations from dbSNP and Humsavar for AURKC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs758097 -- 57,231,335(+) GACGC(A/G)GGGAA intron-variant
rs758098 -- 57,231,671(+) TCCTC(C/T)CCTCT intron-variant
rs758099 -- 57,231,966(+) ATTGG(C/T)ATCCC intron-variant
rs1008073 -- 57,229,351(+) tgcaa(C/G)atagg upstream-variant-2KB
rs1544491 -- 57,234,304(+) gcctg(C/T)ctcgg intron-variant

Relevant External Links for AURKC Gene

HapMap Linkage Disequilibrium report
AURKC
Human Gene Mutation Database (HGMD)
AURKC

No data available for Structural Variations from Database of Genomic Variants (DGV) for AURKC Gene

Disorders for AURKC Gene

(1) OMIM Diseases for AURKC Gene (603495)

UniProtKB/Swiss-Prot

AURKC_HUMAN
  • Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269 PubMed:17435757, ECO:0000269 PubMed:21733974}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for AURKC Gene

Disease -log(P) Hits PubMed IDs
cancer 12.6 2
tumors 0 1

Relevant External Links for AURKC

Genetic Association Database (GAD)
AURKC
Human Genome Epidemiology (HuGE) Navigator
AURKC
genes like me logo Genes that share disorders with AURKC: view

Publications for AURKC Gene

  1. Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3. (PMID: 10066797) Kimura M. … Okano Y. (J. Biol. Chem. 1999) 3 4 23
  2. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. (PMID: 15499654) Sasai K. … Sen S. (Cell Motil. Cytoskeleton 2004) 3 4 23
  3. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. (PMID: 9799611) Bernard M. … Prigent C. (Genomics 1998) 2 3 4
  4. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. (PMID: 19147683) Dieterich K. … Ray P.F. (Hum. Mol. Genet. 2009) 3 23 49
  5. [Function of aurora kinase C (AURKC) in human reproduction]. (PMID: 19447663) Harbuz R. … Ray P.F. (Gynecol Obstet Fertil 2009) 23 49

Products for AURKC Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Targets in human,mouse,rat
    • Cytoskeleton Regulators in human,mouse,rat
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AURKC
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AURKC
    • Block miRNA regulation of AURKC using miScript Target Protectors
    • Addgene plasmids for AURKC

    Sources for AURKC Gene

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