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AURKC Gene

protein-coding   GIFtS: 59
GCID: GC19P057743

Aurora Kinase C

(Previous name: serine/threonine kinase 13 (aurora/IPL1-like))
(Previous symbol: STK13)
  See AURKC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aurora Kinase C1 2     AIK32 3
STK131 2 3 5     ARK-32 3
AIE22 3 5     ARK32 3
Serine/Threonine Kinase 13 (Aurora/IPL1-Like)1 2     EC 2.7.11.13 8
Aurora 32 3     SPGF52 5
Aurora-Related Kinase 32 3     AurC2
Aurora/IPL1-Related Kinase 32 3     aurora-C2
Aurora/IPL1/Eg2 Protein 22 3     AIRK33
Serine/Threonine-Protein Kinase 132 3     EC 2.7.118
Serine/Threonine-Protein Kinase Aurora-C2 3     

External Ids:    HGNC: 113911   Entrez Gene: 67952   Ensembl: ENSG000001051467   OMIM: 6034955   UniProtKB: Q9UQB93   

Export aliases for AURKC gene to outside databases

Previous GC identifers: GC19P062418 GC19P062433 GC19P054054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AURKC Gene:
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a
chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a
role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is
overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for AURKC Gene:
AURKC (aurora kinase C) is a protein-coding gene. Diseases associated with AURKC include polyploidy, and spermatogenic failure 5. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is AURKA.

UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that
acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct
chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle
assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions
with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and
'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'

Gene Wiki entry for AURKC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AURKC gene promoter:
         FOXF2   AML1a   GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAURKC promoter sequence
   Search Chromatin IP Primers for AURKC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AURKC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

AURKC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057743:  view genomic region     (about GC identifiers)

Start:
57,742,377 bp from pter      End:
57,746,916 bp from pter
Size:
4,540 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9 (See protein sequence)
Recommended Name: Aurora kinase C  
Size: 309 amino acids; 35591 Da
Subunit: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin,
INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1
Secondary accessions: O60681 O75442 Q6AZY8 Q6DLZ0 Q9UPK5
Alternative splicing: 3 isoforms:  Q9UQB9-1   Q9UQB9-2   Q9UQB9-3   

Explore the universe of human proteins at neXtProt for AURKC: NX_Q9UQB9

Explore proteomics data for AURKC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys53, Lys130, Lys197
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AURKC (Q9UQB9) (see all 12)
     CGTLDYL  EHQLRRE  SRRVLPP  LCYELLVG 


    See AURKC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001015878.1  NP_001015879.1  NP_003151.2  

    ENSEMBL proteins: 
     ENSP00000407162   ENSP00000302898   ENSP00000468918   ENSP00000469983   ENSP00000471830  
     ENSP00000470465   ENSP00000469894   ENSP00000406798  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: aurora kinase C
    Aurora kinase (Aur) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQB9

    ProtoNet protein and cluster: Q9UQB9

    UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AURKC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AURKC_HUMAN, Q9UQB9
    Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that
    acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct
    chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle
    assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions
    with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and
    'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and
    protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with
    INCENP, which acts also as an activator
    Induction: Expression is cell cycle-regulated, with an increase during G2 and M phases

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15670791
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19774610
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with AURKC           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AURKC:
     Decreased Hepatitis C virus re  Decreased substrate adherent c 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aurkc):
     reproductive system 

    Find genes that share phenotypes with AURKC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aurkctm1Lex for AURKC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AURKC
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AURKC_HUMAN, Q9UQB9: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.
    Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a
    dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the
    midbody during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000793condensed chromosome IDA15670791
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005819spindle TAS19774610

    Find genes that share ontologies with AURKC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AURKC About    
    See pathways by source

    SuperPathContained pathways About
    1Aurora B signaling
    Aurora B signaling
    Signaling by Aurora kinases0.00
    Aurora C signaling0.00
    2ERK Signaling
    Molecular Mechanisms of Cancer0.51
    3Sweet Taste Signaling
    Sperm Motility0.37
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with AURKC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AURKC
        Molecular Mechanisms of Cancer
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for AURKC
        Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for AURKC
        Aurora C signaling
    Aurora B signaling
    Signaling by Aurora kinases


        Pathway & Disease-focused RT2 Profiler PCR Arrays including AURKC: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AURKC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AURKC (Q9UQB93 ENSP000003028984) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204221O152133I2D: score=1 
    ENSG00000206284O152133I2D: score=1 
    ENSG00000226916O152133I2D: score=1 
    ENSG00000236222O152133I2D: score=1 
    HIST1H2BCP628073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis TAS10066797
    GO:0006468protein phosphorylation IDA15670791
    GO:0007126meiotic nuclear division IEA--
    GO:0008608attachment of spindle microtubules to kinetochore TAS19774610
    GO:0016570histone modification TAS19774610

    Find genes that share ontologies with AURKC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for AURKC (see all 28)     About this table
    CompoundAction CAS #
    AMG-900potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C[945595-80-2]
    Anacardic acidselectively activate Aurora kinase A-mediated phosphorylation of histone H3[16611-84-0]
    AT9283novel inhibitor of aurora kinase[896466-04-9]
    Aurora A Inhibitor Inovel, potent, and selective inhibitor of Aurora A[1158838-45-9]
    AZD1152selective Aurora B kinase inhibitor[722543-31-9]
    Barasertib (AZD1152-HQPA)potent aurora kinase inhibitor[722544-51-6]
    CCT129202ATP-competitively inhibits Aurora A, Aurora B and Aurora C[942947-93-5]
    CCT137690highly selective inhibitor of Aurora A, Aurora B and Aurora C[1095382-05-0]
    CYC116potent inhibitor of Aurora A/B[693228-63-6]
    Danusertib (PHA-739358)potent small-molecule inhibitor of aurora B kinase[827318-97-8]

    Browse Tocris compounds for AURKC

    2 HMDB Compounds for AURKC    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AURKC gene (3 alternative transcripts): 
    NM_001015878.1  NM_001015879.1  NM_003160.2  

    Unigene Cluster for AURKC:

    Aurora kinase C
    Hs.98338  [show with all ESTs]
    Unigene Representative Sequence: AF059681
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415300(uc002qoc.3) ENST00000302804(uc002qoe.3 uc010etv.3)
    ENST00000601799 ENST00000599062 ENST00000598785 ENST00000596375 ENST00000594599
    ENST00000448930(uc002qod.3)
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    Additional mRNA sequence: 

    AB017332.1 AF054621.1 AF059681.1 AK301886.1 AY661554.1 AY714054.1 BC075064.2 

    6 DOTS entries:

    DT.407053  DT.92047796  DT.102821133  DT.101976867  DT.121497704  DT.99963318 

    18 AceView cDNA sequences:

    BX092186 BQ884154 AA421265 AF054621 AY661554 BC075064 BM995321 CF455900 
    AF059681 AI206603 NM_003160 AA421312 AB017332 AW969883 AI204621 AI564072 
    AA484664 AI262745 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AURKC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -                                                         
    SP2:                                                                        
    SP3:              -                                                         
    SP4:                                                                        


    ECgene alternative splicing isoforms for AURKC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AURKC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGAAAGT
    AURKC Expression
    About this image

    AURKC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AURKC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98338

    UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
    Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in
    a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AURKC: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for AURKC
    OriGene qSTAR qPCR primer pairs in human, mouse for AURKC
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat AURKC
    QuantiTect SYBR Green Assays in human, mouse, rat AURKC
    QuantiFast Probe-based Assays in human, mouse, rat AURKC
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AURKC gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aurkc1 , 5 aurora kinase C1, 5 81.87(n)1
    79.56(a)1
      7 (4.06 cM)5
    208711  NM_001080965.11  NP_001074434.11 
     69954435 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    GL343400.1(501601-511324)
    zebrafish
    (Danio rerio)
    Actinopterygii aurkb6
    aurora kinase B
    63(a)
    1 → many
    14(2647-7578) ENSDARG00000037640
    fruit fly
    (Drosophila melanogaster)
    Insecta ial1 IplI-aurora-like kinase 58.79(n)
    51.97(a)
      34504  NM_057988.4  NP_477336.1 
    worm
    (Caenorhabditis elegans)
    Secernentea air-26
    Protein AIR-2 (air-2) mRNA, complete cds
    53(a)
    1 → many
    I(5937477-5938885) WBGene00000099
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IPL1(YPL209C)4 Aurora kinase subunit of the conserved chromosomal more   --   16(157593-156490) 855892  NP_015115.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AUR31 AUR3 57.28(n)
    57.41(a)
      819157  NM_130111.3  NP_182073.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07650001 Os03g0765000 57.48(n)
    57.09(a)
      4334220  NM_001057908.1  NP_001051373.1 


    ENSEMBL Gene Tree for AURKC (if available)
    TreeFam Gene Tree for AURKC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AURKC gene
    AURKA2  STK362  AURKB2  
    Selected SIMAP similar genes for AURKC using alignment to 5 protein entries:     AURKC_HUMAN (see all proteins) (see all similar genes):
    AURKA    AURKB    PKN2    PLK4    PTK7    MARK4
    CDK7    CDKL1    KIN27    MARK1    MARK2    ULK3
    CDK3    NUAK1    Par1b    STK36    RPS6KA2    PRKACA

    Find genes that share paralogs with AURKC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for AURKC (see all 215)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0403864
    A lung squamous cell carcinoma sample4--see VAR_0403862 E Q mis40--------
    VAR_0403854
    A lung adenocarcinoma sample4--see VAR_0403852 G E mis40--------
    VAR_0403874
    A lung adenocarcinoma sample4--see VAR_0403872 H Q mis40--------
    rs1422692861,2
    C--57742494(+) CTGCA-/GGACGA
    GCAGGATT
    GGAAG
    3 -- ut51 int10--------
    rs586829461,2
    C--57742497(+) CAGGA-/CGAGCA
    GGATTGGA
    AGCGC
    3 -- ut51 int10--------
    rs589455721,2
    C--57742497(+) CAGGA-/CGAGCAG 3 -- ut51 int10--------
    rs1120393031,2
    C--57742497(+) CAGGAA/CGAGCA 3 -- ut51 int10--------
    rs590747071,2
    C--57742502(+) CGAGC-/AGGATT
    GGAAGCG
    /G
    CCCCG
    4 -- ut51 cds1 int10--------
    rs590949591,2
    C--57742502(+) CGAGC-/AGGA  
      TTGGAA
    GCGCC
    3 -- ut51 int10--------
    rs1124525721,2
    C,F--57745260(+) ACACTT/CGGCTA 3 -- int13Minor allele frequency- C:0.40WA CSA 5

    HapMap Linkage Disequilibrium report for AURKC (57742377 - 57746916 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AURKC: --
    Human Gene Mutation Database (HGMD): AURKC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AURKC
    DNA2.0 Custom Variant and Variant Library Synthesis for AURKC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603495   
    OMIM disorders: 243060  
    UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
  • Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects.
    Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility,
    oversized irregular heads, and abnormal midpiece and acrosome. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 3 diseases for AURKC:    
    About MalaCards
    polyploidy    spermatogenic failure 5    myotonia


    Find genes that share disorders with AURKC           About GenesLikeMe

    2 Novoseek inferred disease relationships for AURKC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 12.6 2 15476560 (1), 10066797 (1)
    tumors 0 1 10066797 (1)

    Genetic Association Database (GAD): AURKC
    Human Genome Epidemiology (HuGE) Navigator: AURKC (3 documents)

    Export disorders for AURKC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AURKC gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with AURKC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. (PubMed id 9799611)1, 2, 3 Bernard M.... Prigent C. (Genomics 1998)
    2. Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3. (PubMed id 10066797)1, 2, 9 Kimura M.... Okano Y. (J. Biol. Chem. 1999)
    3. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. (PubMed id 15499654)1, 2, 9 Sasai K.... Sen S. (Cell Motil. Cytoskeleton 2004)
    4. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. (PubMed id 19147683)1, 4, 9 Dieterich K....Ray P.F. (Hum. Mol. Genet. 2009)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis. (PubMed id 21733974)1, 2 Ben Khelifa M.... Ray P.F. (Mol. Hum. Reprod. 2011)
    7. A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. (PubMed id 21493633)1, 2 Avo Santos M.... Baart E.B. (Hum. Reprod. 2011)
    8. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. (PubMed id 21531210)1, 2 Gabillard J.C.... Arlot-Bonnemains Y. (Biochem. Biophys. Res. Commun. 2011)
    9. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. (PubMed id 17435757)1, 2 Dieterich K.... Ray P.F. (Nat. Genet. 2007)
    10. Aurora C is directly associated with Survivin and required for cytokinesis. (PubMed id 15938719)1, 2 Yan X.... Yu L. (Genes Cells 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6795 HGNC: 11391 AceView: AURKC Ensembl:ENSG00000105146 euGenes: HUgn6795
    ECgene: AURKC H-InvDB: AURKC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AURKC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AURKC gene:
    Search GeneIP for patents involving AURKC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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