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Aliases for AURKC Gene

Aliases for AURKC Gene

  • Aurora Kinase C 2 3 5
  • Serine/Threonine Kinase 13 (Aurora/IPL1-Like) 2 3
  • Serine/Threonine-Protein Kinase Aurora-C 3 4
  • Serine/Threonine-Protein Kinase 13 3 4
  • Aurora/IPL1-Related Kinase 3 3 4
  • Aurora-Related Kinase 3 3 4
  • EC 2.7.11.1 4 61
  • Aurora 3 3 4
  • STK13 3 4
  • ARK-3 3 4
  • AIE2 3 4
  • AIK3 3 4
  • ARK3 3 4
  • Epididymis Secretory Protein Li 90 3
  • Aurora/IPL1/EG2 Protein 2 3
  • Aurora/IPL1/Eg2 Protein 2 4
  • EC 2.7.11 61
  • HEL-S-90 3
  • Aurora-C 3
  • SPGF5 3
  • AIRK3 4
  • AurC 3

External Ids for AURKC Gene

Previous HGNC Symbols for AURKC Gene

  • STK13

Previous GeneCards Identifiers for AURKC Gene

  • GC19P062418
  • GC19P062433
  • GC19P057743
  • GC19P054054

Summaries for AURKC Gene

Entrez Gene Summary for AURKC Gene

  • This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for AURKC Gene

AURKC (Aurora Kinase C) is a Protein Coding gene. Diseases associated with AURKC include Spermatogenic Failure 5 and Macrozoospermia. Among its related pathways are Aurora B signaling and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKB.

UniProtKB/Swiss-Prot for AURKC Gene

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at Ser-10 and Ser-28. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at Ser-228.

Gene Wiki entry for AURKC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKC Gene

Genomics for AURKC Gene

Regulatory Elements for AURKC Gene

Enhancers for AURKC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057190 0.5 ENCODE 18.4 -38.6 -38555 1.9 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 ZNF207 KLF7 AURKC ZNF548 ZNF134 ZNF550 ZNF264 ZNF417 ZIM3 ZNF805 DUXA LOC105372476
GH19F057171 0.5 Ensembl ENCODE 17.2 -58.0 -57960 2.0 ZNF48 ZNF2 ZNF366 ZNF548 SP3 CEBPB ZFP69B ZNF585B ZNF341 GLIS1 LOC100132009 ZNF17 ZNF134 ZNF773 ZNF417 ZNF805 ZNF606 ZNF549 AURKC ZNF256
GH19F057239 0.4 ENCODE 15.3 +10.8 10789 2.6 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF264 ZNF805 AURKC ZNF471 ZNF548 ZNF543 ZNF134 ZFP28 ENSG00000268713
GH19F057809 1.2 FANTOM5 ENCODE 14 +582.9 582858 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
GH19F057663 1.1 FANTOM5 ENCODE 14 +434.2 434249 1.6 ZNF76 ARID4B ZNF48 ZNF2 RARA GLIS2 ZNF366 THAP11 ZNF362 SP3 ZIM3 AURKC ZNF671 USP29 ZNF256 ZNF749 ZNF419 ZNF211 RPL19P19 VN1R1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AURKC on UCSC Golden Path with GeneCards custom track

Genomic Location for AURKC Gene

Chromosome:
19
Start:
57,230,360 bp from pter
End:
57,235,550 bp from pter
Size:
5,191 bases
Orientation:
Plus strand

Genomic View for AURKC Gene

Genes around AURKC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKC Gene

Proteins for AURKC Gene

  • Protein details for AURKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQB9-AURKC_HUMAN
    Recommended name:
    Aurora kinase C
    Protein Accession:
    Q9UQB9
    Secondary Accessions:
    • O60681
    • O75442
    • Q6AZY8
    • Q6DLZ0
    • Q9UPK5

    Protein attributes for AURKC Gene

    Size:
    309 amino acids
    Molecular mass:
    35591 Da
    Quaternary structure:
    • Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.

    Alternative splice isoforms for AURKC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AURKC Gene

Post-translational modifications for AURKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for AURKC Gene

Gene Families for AURKC Gene

IUPHAR :

Suggested Antigen Peptide Sequences for AURKC Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQB9

UniProtKB/Swiss-Prot:

AURKC_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKC: view

Function for AURKC Gene

Molecular function for AURKC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at Ser-10 and Ser-28. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at Ser-228.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle-regulated, with an increase during G2 and M phases.

Enzyme Numbers (IUBMB) for AURKC Gene

Gene Ontology (GO) - Molecular Function for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 15670791
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with AURKC: view
genes like me logo Genes that share phenotypes with AURKC: view

Human Phenotype Ontology for AURKC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for AURKC Gene

MGI Knock Outs for AURKC:

Animal Model Products

  • Taconic Biosciences Mouse Models for AURKC

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for AURKC Gene

Localization for AURKC Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKC Gene

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. {ECO:0000269 PubMed:21531210}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKC Gene COMPARTMENTS Subcellular localization image for AURKC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000780 condensed nuclear chromosome, centromeric region IBA --
GO:0000793 condensed chromosome IDA 15670791
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with AURKC: view

Pathways & Interactions for AURKC Gene

genes like me logo Genes that share pathways with AURKC: view

Pathways by source for AURKC Gene

1 GeneTex pathway for AURKC Gene
1 Cell Signaling Technology pathway for AURKC Gene
2 Qiagen pathways for AURKC Gene

SIGNOR curated interactions for AURKC Gene

Activates:

Gene Ontology (GO) - Biological Process for AURKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IEA --
GO:0006468 protein phosphorylation IEA,IDA 15670791
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with AURKC: view

Drugs & Compounds for AURKC Gene

(32) Drugs for AURKC Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CYC116 Investigational Pharma inhibitor Potent Aurora A/B inhibitor, Inhibitors of mitosis Aurora kinase inhibitors 0
AT9283 Investigational Pharma Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
GSK1070916 Pharma inhibitor Aurora B/C inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
AMG-900 Pharma Aurora kinase inhibitor 0

(1) Additional Compounds for AURKC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(21) ApexBio Compounds for AURKC Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
Danusertib (PHA-739358) Pan-aurora kinase inhibitor 827318-97-8
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor 656820-32-5
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKC: view

Transcripts for AURKC Gene

Unigene Clusters for AURKC Gene

Aurora kinase C:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AURKC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for AURKC Gene

GeneLoc Exon Structure for
AURKC
ECgene alternative splicing isoforms for
AURKC

Expression for AURKC Gene

mRNA expression in normal human tissues for AURKC Gene

mRNA differential expression in normal tissues according to GTEx for AURKC Gene

This gene is overexpressed in Testis (x17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AURKC Gene



Protein tissue co-expression partners for AURKC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AURKC Gene:

AURKC

SOURCE GeneReport for Unigene cluster for AURKC Gene:

Hs.98338

mRNA Expression by UniProt/SwissProt for AURKC Gene:

Q9UQB9-AURKC_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
genes like me logo Genes that share expression patterns with AURKC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for AURKC Gene

Orthologs for AURKC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKC 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia STK13 35
  • 87 (a)
OneToOne
AURKC 34
  • 85.51 (n)
cow
(Bos Taurus)
Mammalia LOC618599 34
  • 84.46 (n)
-- 35
  • 82 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Aurkc 34 16 35
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii aurkb 35
  • 63 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8843 34
fruit fly
(Drosophila melanogaster)
Insecta ial 34
  • 58.79 (n)
aur 35
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007855 34
  • 56.54 (n)
worm
(Caenorhabditis elegans)
Secernentea air-2 35
  • 53 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 35 37
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AUR3 34
  • 57.28 (n)
soybean
(Glycine max)
eudicotyledons Gma.9652 34
rice
(Oryza sativa)
Liliopsida Os03g0765000 34
  • 57.48 (n)
corn
(Zea mays)
Liliopsida Zm.17459 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 35
  • 59 (a)
OneToMany
Species where no ortholog for AURKC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AURKC Gene

ENSEMBL:
Gene Tree for AURKC (if available)
TreeFam:
Gene Tree for AURKC (if available)

Paralogs for AURKC Gene

Paralogs for AURKC Gene

Pseudogenes.org Pseudogenes for AURKC Gene

genes like me logo Genes that share paralogs with AURKC: view

Variants for AURKC Gene

Sequence variations from dbSNP and Humsavar for AURKC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040385 A lung adenocarcinoma sample
VAR_040386 A lung squamous cell carcinoma sample
VAR_040387 A lung adenocarcinoma sample
rs121908654 Pathogenic 57,234,985(+) GCTCT(A/G)CTATG nc-transcript-variant, reference, missense
rs397515484 Pathogenic 57,233,458(+) CCCAC(A/G)GATAA splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for AURKC Gene

Variant ID Type Subtype PubMed ID
esv3893256 CNV loss 25118596
nsv580400 CNV gain 21841781

Variation tolerance for AURKC Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AURKC Gene

Human Gene Mutation Database (HGMD)
AURKC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AURKC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKC Gene

Disorders for AURKC Gene

MalaCards: The human disease database

(3) MalaCards diseases for AURKC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 5
  • infertility associated with multi-tailed spermatozoa and excessive dna
macrozoospermia
  • infertility associated with multi-tailed spermatozoa and excessive dna
infertility
- elite association - COSMIC cancer census association via MalaCards
Search AURKC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AURKC_HUMAN
  • Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269 PubMed:17435757, ECO:0000269 PubMed:21733974}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for AURKC

Genetic Association Database (GAD)
AURKC
Human Genome Epidemiology (HuGE) Navigator
AURKC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AURKC
genes like me logo Genes that share disorders with AURKC: view

No data available for Genatlas for AURKC Gene

Publications for AURKC Gene

  1. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. (PMID: 19147683) Dieterich K. … Ray P.F. (Hum. Mol. Genet. 2009) 3 22 46 64
  2. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. (PMID: 15499654) Sasai K. … Sen S. (Cell Motil. Cytoskeleton 2004) 3 4 22 64
  3. Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3. (PMID: 10066797) Kimura M. … Okano Y. (J. Biol. Chem. 1999) 3 4 22 64
  4. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. (PMID: 9799611) Bernard M. … Prigent C. (Genomics 1998) 2 3 4 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for AURKC Gene

Sources for AURKC Gene

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