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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AURKC Gene

protein-coding   GIFtS: 57
GCID: GC19P057743

aurora kinase C

(Previous name: serine/threonine kinase 13 (aurora/IPL1-like) )
(Previous symbol: STK13)
 Explore 12 diseases affiliated with
AURKC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AURKC    

Aliases
for AURKC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aurora Kinase C1 2     Serine/Threonine-Protein Kinase 132 3
STK131 2 3 5     Serine/Threonine-Protein Kinase Aurora-C2 3
ARK31 2 3     AIK32 3
AIE22 3 5     ARK-32 3
AurC1 2     EC 2.7.11.13 8
Serine/Threonine Kinase 13 (Aurora/IPL1-Like)1 2     SPGF52
Aurora 32 3     Aurora-C1
Aurora-Related Kinase 32 3     AIRK33
Aurora/IPL1-Related Kinase 32 3     EC 2.7.118
Aurora/IPL1/Eg2 Protein 22 3     

External Ids:    HGNC: 113911   Entrez Gene: 67952   Ensembl: ENSG000001051467   OMIM: 6034955   UniProtKB: Q9UQB93   

Export aliases for AURKC gene to outside databases

Previous GC identifers: GC19P062418 GC19P062433 GC19P054054


Summaries
for AURKC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AURKC:
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a
chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in
organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in
several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as
a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome
alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays
also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can
rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1,
another protein involved in cell division, at 'Ser-228'

Gene Wiki entry for AURKC


Genomic Views
for AURKC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AURKC gene promoter:
         FOXF2   AML1a   GCNF-1   GCNF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AURKC promoter sequence
   Search SABiosciences Chromatin IP Primers for AURKC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.3-qter

AURKC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057743:  view genomic region     (about GC identifiers)

Start:
 57,742,377 bp from pter      End:
 57,746,916 bp from pter
Size:
 4,540 bases      Orientation:
 plus strand

Proteins
for AURKC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9 (See protein sequence)
Recommended Name: Aurora kinase C  
Size: 309 amino acids; 35591 Da
Subunit: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin,
INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1
Subcellular location: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes
in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from
separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during
cytokinesis
Secondary accessions: O60681 O75442 Q6AZY8 Q6DLZ0 Q9UPK5
Alternative splicing: 3 isoforms:  Q9UQB9-1   Q9UQB9-2   Q9UQB9-3   

Explore the universe of human proteins at neXtProt for AURKC: NX_Q9UQB9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQB9

    • 4/12 DME Specific Peptides for AURKC (Q9UQB9) (see all 12)
     CGTLDYL  EHQLRRE  SRRVLPP  LCYELLVG 

    AURKC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001015878.1  NP_001015879.1  NP_003151.2  

    ENSEMBL proteins: 
     ENSP00000407162   ENSP00000302898   ENSP00000406798  

    Human Recombinant Protein Products: 
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    Novus Biologicals AURKC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AURKC

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000793condensed chromosome IDA15670791
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005819spindle TAS19774610


    AURKC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AURKC

    Protein Domains /
    Families
    for AURKC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AURKC for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQB9

    ProtoNet protein and cluster: Q9UQB9

    UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for AURKC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
    Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as
    a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome
    alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays
    also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can
    rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1,
    another protein involved in cell division, at 'Ser-228'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein
    phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which
    acts also as an activator
    Induction: Expression is cell cycle-regulated, with an increase during G2 and M phases

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for AURKC

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15670791
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19774610
    GO:0005524ATP binding IEA--


    AURKC for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AURKC:
     Decreased Hepatitis C virus re  Decreased substrate adherent c 

    Animal Models:
         Mouse knock-out Aurkctm1Lex for AURKC
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Aurkc):
     reproductive system 

    AURKC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AURKC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Aurora C signaling
    		Aurora C signaling1.00
    		Signaling by Aurora kinases0.50
    2Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    3Aurora B signaling
    		Aurora B signaling1.00
    4Rho Family GTPases
    		Molecular Mechanisms of Cancer0.51
    5Sweet Taste Signaling
    		Sperm Motility0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AURKC
        Molecular Mechanisms of Cancer
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for AURKC
        Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for AURKC 
        Aurora B signaling
    Aurora C signaling
    Signaling by Aurora kinases



    AURKC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AURKC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/69 Interacting proteins for AURKC (Q9UQB93 ENSP000003028984) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis TAS10066797
    GO:0006468protein phosphorylation IDA15670791
    GO:0007126meiosis IEA--
    GO:0008608attachment of spindle microtubules to kinetochore TAS19774610
    GO:0016570histone modification TAS19774610


    AURKC for ontologies           About GeneDecksing



    Drugs & Compounds
    for AURKC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for AURKC:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AURKC

    2 HMDB Compounds for AURKC    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about AURKC 

    Transcripts
    for AURKC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AURKC gene (3 alternative transcripts): 
    NM_001015878.1  NM_001015879.1  NM_003160.2  

    Unigene Cluster for AURKC:

    Aurora kinase C
    Hs.98338  [show with all ESTs]
    Unigene Representative Sequence: AF059681
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415300(uc002qoc.3) ENST00000302804(uc002qoe.3 uc010etv.3)
    ENST00000448930(uc002qod.3)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AURKC (see all 7)
    OriGene shRNA RFP: AURKC
    OriGene siRNA: AURKC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AURKC
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): AURKC (NM_001015878)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AURKC

    Additional cDNA sequence: 

    AB017332.1 AF054621.1 AF059681.1 AK301886.1 AY661554.1 AY714054.1 BC075064.2 

    6 DOTS entries:

    DT.407053  DT.92047796  DT.102821133  DT.101976867  DT.121497704  DT.99963318 

    18 AceView cDNA sequences:

    BQ884154 BX092186 BC075064 AF054621 AY661554 AA421265 BM995321 CF455900 
    AI206603 AF059681 AB017332 AW969883 NM_003160 AI204621 AA421312 AI564072 
    AA484664 AI262745 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AURKC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -                                                         
    SP2:                                                                        
    SP3:              -                                                         
    SP4:                                                                        


    ECgene alternative splicing isoforms for AURKC

    Expression
    for AURKC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AURKC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAGAAAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AURKC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AURKC

    SOURCE GeneReport for Unigene cluster: Hs.98338

    UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
    Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a
    subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase

        SABiosciences Expression via Pathway-Focused PCR Arrays including AURKC: 
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              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKC

    Orthologs
    for AURKC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AURKC gene from 6/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 72(a)
    		 1 → many
    		 GL343400.1(503210-507658)
    zebrafish
    (Danio rerio)    		 Actinopterygii aurkb6
    		 aurora kinase B
    		 64(a)
    		 1 → many
    		 14(2647-7578)
    fruit fly
    (Drosophila melanogaster)    		 Insecta ial1 IplI-aurora-like kinase 58.79(n)
    51.97(a)    		   34504  NM_057988.3  NP_477336.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea air-26
    air-16
    		 Aurora/Ipl1 Related kinase family member (air-1)
    		 53(a)
    43(a)
    		 possible ortholog
    possible ortholog
    		 I(5937479-5938887)
    V(8221390-8223567)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AUR26
    AtAUR16
    (see all 3)    		 serine/threonine-protein kinase aurora-1
    (see all 3)    		 59(a)
    58(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2(11034652-11036910)
    4(15842453-15844536)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 CAMK_CAMK_like_Aur_like.1 - CAMK includes calcium/...
    CAMK_CAMK_like_Aur_like.2 - CAMK includes calcium/...
    		 58(a)
    47(a)
    		 many ↔ many
    many ↔ many
    		 1(4908890-4913370)
    3(31667445-31671597)


    ENSEMBL Gene Tree for AURKC (if available)
    TreeFam Gene Tree for AURKC (if available) 

    Paralogs
    for AURKC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AURKC gene
    AURKA2  AURKB2  
    18/112 SIMAP similar genes for AURKC using alignment to 5 protein entries:     AURKC_HUMAN (see all proteins) (see all similar genes):
    AURKB    AURKA    PLK4    MARK4    PTK7    MARK2
    CDK7    CDKL1    KIN27    MARK1    ULK3    CDK3
    NUAK1    Par1b    STK36    RPS6KA2    BRSK2    CHEK1

    AURKC for paralogs           About GeneDecksing



    Genomic Variants
    for AURKC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 NCBI SNPs in AURKC are shown (see all 169)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1421090091,2
    		--57740492(+) CGGGCA/GTGGTG 3 -- us2k10--------
    rs37610641,2
    		C,--57740509(-) GGACTA/GCAGGT 3 -- us2k10--------
    rs1507573951,2
    		--57740533(+) GTCTGA/GGGCAG 3 -- us2k10--------
    rs37610631,2
    		C,F,--57740608(-) TGTCGT/CCCAGG 3 -- us2k13Minor allele frequency- C:0.33WA NA 6
    rs1827023221,2
    		--57740664(+) GGAATG/TCATAA 3 -- us2k10--------
    rs1449929901,2
    		--57740669(+) GCATAA/GTTATT 3 -- us2k10--------
    rs1870306971,2
    		--57740676(+) TATTTG/TGCTAT 3 -- us2k10--------
    rs1922380211,2
    		--57740703(+) TTAGAA/GCAGTG 3 -- us2k10--------
    rs10080731,2
    		C,F,A,H,--57740719(+) TGCAAG/CATAGG 3 -- us2k117Minor allele frequency- C:0.36NA EA NS WA 1142
    rs1475681621,2
    		--57740733(+) TCAATC/TGATAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for AURKC (57742377 - 57746916 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AURKC: --
    Human Gene Mutation Database (HGMD): AURKC

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for AURKC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AURKC for disorders           About GeneDecksing

    OMIM gene information: 603495   
    OMIM disorders: 243060  
    UniProtKB/Swiss-Prot: AURKC_HUMAN, Q9UQB9
  • Defects in AURKC are the cause of spermatogenic failure type 5 (SPGF5) [MIM:243060]. An infertility disorder
    • caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar
    spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome

    12 diseases for AURKC:    About MalaCards
    ruptured abdominal aortic aneurysm    abdominal aortic aneurysm    aortic aneurysm    male infertility
    cardiac sarcoidosis    infertility    sarcoidosis    breast cancer
    pneumonia    tuberculosis    malaria    mycobacterium tuberculosis

    2 Novoseek disease relationships for AURKC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 12.6 2 15476560 (1), 10066797 (1)
    tumors 0 1 10066797 (1)

    Human Genome Epidemiology (HuGE) Navigator: AURKC (3 documents)

    Export disorders for AURKC gene to outside databases

    Publications
    for AURKC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AURKC gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with AURKC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. (PubMed id 9799611)1, 2, 3 Bernard M.... Prigent C. (1998)
    2. Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3. (PubMed id 10066797)1, 2, 9 Kimura M.... Okano Y. (1999)
    3. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. (PubMed id 15499654)1, 2, 9 Sasai K....Sen S. (2004)
    4. A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis. (PubMed id 21733974)1, 2 Ben Khelifa M.... Ray P.F. (2011)
    5. A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. (PubMed id 21493633)1, 2 Avo Santos M.... Baart E.B. (2011)
    6. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. (PubMed id 21531210)1, 2 Gabillard J.C.... Arlot-Bonnemains Y. (2011)
    7. Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. (PubMed id 17435757)1, 2 Dieterich K.... Ray P.F. (2007)
    8. Aurora C is directly associated with Survivin and required for cytokinesis. (PubMed id 15938719)1, 2 Yan X....Yu L. (2005)
    9. Cloning and characterization of a novel human Aurora C splicing variant. (PubMed id 15670791)1, 2 Yan X.... Yu L. (2005)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)

    External Searches for AURKC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing AURKC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6795 HGNC: 11391 AceView: AURKC Ensembl:ENSG00000105146 euGenes: HUgn6795
    ECgene: AURKC H-InvDB: AURKC

    Other Databases showing AURKC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AURKC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AURKC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AURKC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AURKC gene:
    Search GeneIP for patents involving AURKC

    GeneCards and IP:
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    About This Section

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