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Aliases for AURKB Gene

Aliases for AURKB Gene

  • Aurora Kinase B 2 3 5
  • Serine/Threonine-Protein Kinase Aurora-B 3 4
  • Serine/Threonine-Protein Kinase 12 3 4
  • Serine/Threonine-Protein Kinase 5 3 4
  • Aurora/IPL1-Related Kinase 2 3 4
  • Serine/Threonine Kinase 12 2 3
  • Aurora-Related Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • Aurora-B 2 3
  • Aurora-1 2 3
  • Aurora 1 3 4
  • STK12 3 4
  • AIM-1 3 4
  • ARK-2 3 4
  • STK-1 3 4
  • AIK2 3 4
  • AIM1 3 4
  • ARK2 3 4
  • STK5 3 4
  • Aurora- And Ipl1-Like Midbody-Associated Protein 1 3
  • Aurora- And IPL1-Like Midbody-Associated Protein 1 4
  • Protein Phosphatase 1, Regulatory Subunit 48 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 48 2
  • Aurora Kinase B-Sv1 3
  • Aurora Kinase B-Sv2 3
  • Aurkb-Sv1 3
  • Aurkb-Sv2 3
  • EC 2.7.11 63
  • PPP1R48 3
  • AIRK2 4
  • AurB 3
  • IPL1 3
  • STK1 4

External Ids for AURKB Gene

Previous HGNC Symbols for AURKB Gene

  • STK12

Previous GeneCards Identifiers for AURKB Gene

  • GC17M008050
  • GC17M008308
  • GC17M008048
  • GC17M008108
  • GC17M008006
  • GC17M008218
  • GC17M008264

Summaries for AURKB Gene

Entrez Gene Summary for AURKB Gene

  • This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for AURKB Gene

AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include neuroblastoma, susceptibility and tetraploidy. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKC.

UniProtKB/Swiss-Prot for AURKB Gene

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at Ser-10 and Ser-28 during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.

Tocris Summary for AURKB Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.

Gene Wiki entry for AURKB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKB Gene

Genomics for AURKB Gene

Regulatory Elements for AURKB Gene

Promoters for AURKB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AURKB on UCSC Golden Path with GeneCards custom track

Genomic Location for AURKB Gene

Chromosome:
17
Start:
8,204,731 bp from pter
End:
8,210,776 bp from pter
Size:
6,046 bases
Orientation:
Minus strand

Genomic View for AURKB Gene

Genes around AURKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AURKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AURKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKB Gene

Proteins for AURKB Gene

  • Protein details for AURKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GD4-AURKB_HUMAN
    Recommended name:
    Aurora kinase B
    Protein Accession:
    Q96GD4
    Secondary Accessions:
    • B4DNM4
    • C7G533
    • C7G534
    • C7G535
    • D3DTR4
    • J9JID1
    • O14630
    • O60446
    • O95083
    • Q96DV5
    • Q9UQ46

    Protein attributes for AURKB Gene

    Size:
    344 amino acids
    Molecular mass:
    39311 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPT1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28. Interacts with RNF2/RING1B.
    SequenceCaution:
    • Sequence=AAH13300.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKB Gene

    Alternative splice isoforms for AURKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AURKB Gene

Proteomics data for AURKB Gene at MOPED

Post-translational modifications for AURKB Gene

  • The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.
  • Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
  • Ubiquitination at Lys 4, Lys 31, Lys 56, Lys 168, Lys 202, Lys 211, and Lys 215
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for AURKB (AurB)

Domains & Families for AURKB Gene

Gene Families for AURKB Gene

Graphical View of Domain Structure for InterPro Entry

Q96GD4

UniProtKB/Swiss-Prot:

AURKB_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKB: view

Function for AURKB Gene

Molecular function for AURKB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between GSG2 and AURKB contributes to CPC localization.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at Ser-10 and Ser-28 during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases again after M phase.

Enzyme Numbers (IUBMB) for AURKB Gene

Phenotypes for AURKB Gene

MGI mutant phenotypes for AURKB:
inferred from 6 alleles
GenomeRNAi human phenotypes for AURKB:
genes like me logo Genes that share phenotypes with AURKB: view

Animal Models for AURKB Gene

MGI Knock Outs for AURKB:

Animal Model Products

  • Taconic Biosciences Mouse Models for AURKB

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AURKB Gene

Localization for AURKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKB Gene

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKB Gene COMPARTMENTS Subcellular localization image for AURKB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000780 condensed nuclear chromosome, centromeric region IDA 18195732
GO:0005819 spindle TAS 19774610
GO:0005876 spindle microtubule IBA --
GO:0010369 chromocenter IEA --
genes like me logo Genes that share ontologies with AURKB: view

Pathways & Interactions for AURKB Gene

genes like me logo Genes that share pathways with AURKB: view

SIGNOR curated interactions for AURKB Gene

Gene Ontology (GO) - Biological Process for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20959462
GO:0002903 negative regulation of B cell apoptotic process IDA 20959462
GO:0006468 protein phosphorylation IEA,IDA 21820309
GO:0007051 spindle organization IMP 21820309
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with AURKB: view

Drugs & Compounds for AURKB Gene

(44) Drugs for AURKB Gene - From: HMDB, DGIdb, DrugBank, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Hesperidin Experimental Nutra Target 10
N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine Experimental Pharma Target 0
AT9283 Investigational Pharma inhibitor, Target Aurora kinase/JAK inhibitor, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
CYC116 Investigational Pharma inhibitor Potent Aurora A/B inhibitor, Inhibitors of mitosis Aurora kinase inhibitors 0

(3) Additional Compounds for AURKB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Hesperadin hydrochloride
422513-13-1
TC-A 2317 hydrochloride
1245907-03-2

(5) Tocris Compounds for AURKB Gene

Compound Action Cas Number
Anacardic acid Noncompetitive PCAF/p300 inhibitor 16611-84-0
CCT 137690 Potent pan-Aurora kinase inhibitor 1095382-05-0
Hesperadin hydrochloride Potent Aurora kinase B inhibitor 422513-13-1
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor 1245907-03-2
ZM 447439 Inhibits Aurora kinase B 331771-20-1

(22) ApexBio Compounds for AURKB Gene

Compound Action Cas Number
AMG-900 Aurora kinase inhibitor 945595-80-2
Anacardic acid HAT inhibitor 16611-84-0
AT9283 Aurora kinase/JAK inhibitor 896466-04-9
Aurora A Inhibitor I Aurora A inhibitor 1158838-45-9
Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective 722544-51-6
CCT129202 Aurora kinase inhibitor,ATP-competitive and potent 942947-93-5
CCT137690 Aurora A/B/C inhibitor 1095382-05-0
CYC116 Potent Aurora A/B inhibitor 693228-63-6
ENMD-2076 Selective Aurora A/Flt3 inhibitor 934353-76-1
ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor 1291074-87-7
GSK1070916 Aurora B/C inhibitor 942918-07-2
Hesperadin Aurora B kinase inhibitor 422513-13-1
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective 1010085-13-8
MK-8745 Aurora A inhibitor,potent and selective 885325-71-3
MLN8054 Aurora A inhibitor 869363-13-3
PF-03814735 Aurora A/B inhibitor 942487-16-3
PHA-680632 Aurora kinase inhibitor,novel and potent 398493-79-3
SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective 1146618-41-8
TAK-901 Novel Aurora A/B inhibitor 934541-31-8
VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor 639089-54-6
ZM 447439 Aurora Kinase inhibitor,potent and selective 331771-20-1
genes like me logo Genes that share compounds with AURKB: view

Drug Products

Transcripts for AURKB Gene

Unigene Clusters for AURKB Gene

Aurora kinase B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AURKB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - -
SP14: - - -
SP15: - - -
SP16: - - - - - -
SP17: - - - - -
SP18: - - -
SP19:
SP20:

ExUns: 10a · 10b · 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for AURKB Gene

GeneLoc Exon Structure for
AURKB
ECgene alternative splicing isoforms for
AURKB

Expression for AURKB Gene

mRNA expression in normal human tissues for AURKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKB Gene

This gene is overexpressed in Nerve - Tibial (x4.6) and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for AURKB Gene

This gene is overexpressed in Breast (56.8) and Lung (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AURKB Gene



SOURCE GeneReport for Unigene cluster for AURKB Gene Hs.442658

mRNA Expression by UniProt/SwissProt for AURKB Gene

Q96GD4-AURKB_HUMAN
Tissue specificity: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
genes like me logo Genes that share expression patterns with AURKB: view

Protein tissue co-expression partners for AURKB Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for AURKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AURKB 35
  • 90.86 (n)
  • 93.29 (a)
AURKB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AURKB 35
  • 89.99 (n)
  • 91.84 (a)
AURKB 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurkb 35
  • 83.19 (n)
  • 85.04 (a)
Aurkb 16
Aurkb 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AURKB 35
  • 98.84 (n)
  • 98.26 (a)
AURKB 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aurkb 35
  • 84.07 (n)
  • 85.34 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aurkb 35
  • 66.27 (n)
  • 71.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398457 35
zebrafish
(Danio rerio)
Actinopterygii aurkb 35
  • 69.37 (n)
  • 74.66 (a)
stka 35
aurkb 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta aur 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea air-2 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL101C 35
  • 55.08 (n)
  • 46.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02332g 35
  • 52.62 (n)
  • 49.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 35
  • 50.72 (n)
  • 44.48 (a)
IPL1 36
  • 36 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.9199 35
corn
(Zea mays)
Liliopsida Zm.5439 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00108 35
  • 58.66 (n)
  • 57.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ark1 35
  • 55.94 (n)
  • 63.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 36
  • 59 (a)
OneToMany
Species with no ortholog for AURKB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AURKB Gene

ENSEMBL:
Gene Tree for AURKB (if available)
TreeFam:
Gene Tree for AURKB (if available)

Paralogs for AURKB Gene

Paralogs for AURKB Gene

Pseudogenes.org Pseudogenes for AURKB Gene

genes like me logo Genes that share paralogs with AURKB: view

Variants for AURKB Gene

Sequence variations from dbSNP and Humsavar for AURKB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3027254 - 8,207,274(+) ATGAA(A/C)TGGCT intron-variant, nc-transcript-variant, reference, missense
rs1059476 - 8,205,013(+) CTCCC(A/G)TGGGC nc-transcript-variant, reference, missense
rs55878091 - 8,207,622(+) CAGGG(A/G)CAGCT nc-transcript-variant, reference, missense
VAR_040384 -
rs1059456 -- 8,206,843(-) CGGAG(A/G)AGGAT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AURKB Gene

Variant ID Type Subtype PubMed ID
nsv907658 CNV Loss 21882294
nsv833353 CNV Loss 17160897

Variation tolerance for AURKB Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AURKB Gene

HapMap Linkage Disequilibrium report
AURKB
Human Gene Mutation Database (HGMD)
AURKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKB Gene

Disorders for AURKB Gene

MalaCards: The human disease database

(3) MalaCards diseases for AURKB Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma, susceptibility
tetraploidy
  • tetraploidy syndrome
giant cell glioblastoma
  • monstrocellular sarcoma [obs]
- elite association - COSMIC cancer census association via MalaCards
Search AURKB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AURKB_HUMAN
  • Note=Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.

Relevant External Links for AURKB

Genetic Association Database (GAD)
AURKB
Human Genome Epidemiology (HuGE) Navigator
AURKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AURKB
genes like me logo Genes that share disorders with AURKB: view

No data available for Genatlas for AURKB Gene

Publications for AURKB Gene

  1. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. (PMID: 9858806) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 1998) 2 3 4 23 67
  2. Widespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase. (PMID: 20157117) Li Y. … Prochownik E.V. (J. Biol. Chem. 2010) 3 23
  3. Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase. (PMID: 20177074) Perrera C. … Rusconi L. (J. Biol. Chem. 2010) 3 23
  4. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. (PMID: 20231380) Liu D. … Lampson M.A. (J. Cell Biol. 2010) 3 23
  5. The catalytic role of INCENP in Aurora B activation and the kinetic mechanism of Aurora B/INCENP. (PMID: 18767990) Yang J. … Lai Z. (Biochem. J. 2009) 3 23

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