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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AURKB Gene

protein-coding   GIFtS: 71
GCID: GC17M008108

aurora kinase B

(Previous name: serine/threonine kinase 12 )
(Previous symbol: STK12)
 Explore 45 diseases affiliated with
AURKB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AURKB    

Aliases
for AURKB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aurora Kinase B1 2     Serine/Threonine-Protein Kinase 52 3
ARK21 2 3 5     Serine/Threonine-Protein Kinase Aurora-B2 3
STK121 2 3 5     ARK-22 3
AIM-11 2 3     STK-12 3
STK51 2 3     EC 2.7.11.13 8
AIK22 3 5     Aik21
AIM12 3 5     Aurkb-Sv11
AurB1 2     Aurkb-Sv21
IPL11 2     Aurora Kinase B-Sv12
PPP1R481 2     Aurora Kinase B-Sv22
Serine/Threonine Kinase 121 2     Aurora-11
Aurora 12 3     Aurora-B1
Aurora- And IPL1-Like Midbody-Associated Protein 12 3     Protein Phosphatase 1, Regulatory Subunit 482
Aurora-Related Kinase 22 3     AIRK23
Aurora/IPL1-Related Kinase 22 3     STK13
Serine/Threonine-Protein Kinase 122 3     EC 2.7.118

External Ids:    HGNC: 113901   Entrez Gene: 92122   Ensembl: ENSG000001789997   OMIM: 6049705   UniProtKB: Q96GD43   

Export aliases for AURKB gene to outside databases

Previous GC identifers: GC17M008050 GC17M008308 GC17M008048 GC17M008006


Summaries
for AURKB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AURKB:
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two
members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of
segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene
is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as
a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome
alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of
cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB
phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to
increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA,
DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop
involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin
filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during
mitosis. A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for
kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional
activity

summary for AURKB:
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in
regulating many of the processes that are pivotal to mitosis. Each isoform, Aurora A, Aurora B and Aurora C,
has a different function in the control of mitosis. Aurora B is the catalytic component of the chromosomal
passenger complex (CPC) that is critical for the correct progression through and completion of mitosis. CPC
is composed of three other proteins, survivin, INCENP and borealin, which are all substrates for Aurora B
and function to regulate the activity of this enzyme. The CPC initially forms along chromosome arms, then
concentrates at the centromere before finally localizing to the spindle midzone during cytokinesis.
Functions of the CPC include condensation of chromosomes, formation of the bipolar spindle, attachment of
the chromosomes to the mitotic spindle, regulation of the spindle checkpoint and completion of cytokinesis.
An important target of Aurora B is histone H3, which is a critical regulator of chromosome condensation. H3
phosphorylation is a biomarker of Aurora B activity. Since their discovery in the 1990s, Aurora kinases have
been strongly linked to the progression of human cancers. Aurora A maps to human chromosome 20q13 and Aurora
B to human chromosome 17q13.1, which are loci altered frequently in human cancers. Overexpression of Aurora
A and B is seen in many cancers, but these enzymes are not oncoproteins, as concomitant oncogenic mutations
are required to promote tumor progression. Aurora kinase inhibitors are an intense area of research for the
development of anticancer therapies.

Gene Wiki entry for AURKB (Aurora B kinase)


Genomic Views
for AURKB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AURKB gene promoter:
         AREB6   PPAR-gamma1   SREBP-1a   SREBP-1c   Olf-1   PPAR-gamma2   LCR-F1   ITF-2   Tal-1beta   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AURKB promoter sequence
   Search SABiosciences Chromatin IP Primers for AURKB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AURKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

AURKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008108:  view genomic region     (about GC identifiers)

Start:
 8,108,049 bp from pter      End:
 8,113,918 bp from pter
Size:
 5,870 bases      Orientation:
 minus strand

Proteins
for AURKB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4 (See protein sequence)
Recommended Name: Aurora kinase B  
Size: 344 amino acids; 39311 Da
Cofactor: Magnesium
Subunit: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin,
INCENP, AURKB and AURKC. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPT1
and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active,
Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the
middle kinase domain) with NOC2L (via the N- and C-terminus domains)
Subcellular location: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on
chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and
midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body. Proper localization of the
active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC
Sequence caution: Sequence=AAH13300.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for AURKB:
4AF3 (3D)    
Secondary accessions: C7G533 C7G534 C7G535 D3DTR4 O14630 O60446 O95083 Q96DV5 Q9UQ46
Alternative splicing: 3 isoforms:  Q96GD4-1   Q96GD4-2   Q96GD4-3   (Not expressed in normal liver, high expression in metastatic liver)

Explore the universe of human proteins at neXtProt for AURKB: NX_Q96GD4

Post-translational modifications:

  • The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism.
    • Thr-232 phosphorylation is indispensable for the AURKB kinase activity1
  • Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3
    • ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis.
    During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle
    midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex
    may not lead to its degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96GD4

    • 4/18 DME Specific Peptides for AURKB (Q96GD4) (see all 18)
     TAAPGQK  LYNYFYD  CGTLDYL  EHQLRRE 

    AURKB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243763.1  NP_004208.2  

    ENSEMBL proteins: 
     ENSP00000313950   ENSP00000443869   ENSP00000463999   ENSP00000462858   ENSP00000462207  
     ENSP00000461981   ENSP00000463636   ENSP00000462930   ENSP00000464031   ENSP00000462027  
     ENSP00000445866  
    Reactome Protein details: Q96GD4
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant AURKB Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for AURKB
    OriGene Purified Protein: AURKB
    OriGene Protein Over-expression Lysate: AURKB
    OriGene Custom Protein Services for AURKB 
    GenScript Custom Purified and Recombinant Proteins Services for AURKB
    Novus Biologicals AURKB Proteins
    Novus Biologicals AURKB Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for AURKB
    Uscn Proteins for AURKB

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000779condensed chromosome, centromeric region IDA19465021
    GO:0000780condensed nuclear chromosome, centromeric region IDA18195732
    GO:0005634nucleus IDA--
    GO:0005819spindle TAS19774610
    GO:0005829cytosol TAS--


    AURKB for ontologies           About GeneDecksing



    AURKB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AURKB
    R&D Systems Antibodies for AURKB (Aurora B)
    Cell Signaling Technology (CST) Antibodies for AURKB  (AurB)
    OriGene Antibodies (see all 2): AURKB
    OriGene Custom Antibody Services for AURKB 
    GenScript Superior Antibodies for AURKB
    Novus Biologicals AURKB Antibodies
    Abcam antibodies for AURKB 
    Uscn Antibodies for AURKB
    ThermoFisher Antibody for AURKB

    Assay Products for AURKB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AURKB
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AURKB

    Protein Domains /
    Families
    for AURKB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AURKB for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96GD4

    ProtoNet protein and cluster: Q96GD4

    UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for AURKB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
    Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as
    a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome
    alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
    Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of
    cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB
    phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to
    increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA,
    DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop
    involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin
    filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during
    mitosis. A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for
    kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional
    activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activity is greatly increased when AURKB is within the CPC complex. In particular,
    AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between GSG2 and AURKB contributes to CPC
    localization
    Induction: Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases
    again after M phase

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target AURKB:
    hsa-mir-24 (MIRT000120), hsa-mir-16 (MIRT004742), hsa-let-7b (MIRT001649)

    OriGene 3'-UTR Clone: AURKB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AURKB
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate AURKB (see all 11):
    hsa-miR-3173-3p hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-3927
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AURKB (see all 7)
    OriGene shRNA RFP: AURKB
    OriGene siRNA: AURKB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AURKB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AURKB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AURKB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AURKB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AURKB (NM_004217)
    Sino Biological Human cDNA Clone for AURKB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AURKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for AURKB
    Search LifeMap BioReagents cell lines for AURKB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKB

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19774610
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    AURKB for ontologies           About GeneDecksing


    11 GenomeRNAi human phenotypes for AURKB:
     Cell division defect  Decreased cell number, increas  Decreased substrate adherent c  Decreased telomerase activity 
     Decreased viability  Decreased viability of wild-ty  Increased ID2::GFP protein exp  Increased cell death in breast 
     Increased cell number in G2M,   Paclitaxel antagonistic effect  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-out Aurkbtm1.2Mama for AURKB
         10 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Aurkb):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  no phenotypic analysis  reproductive system  tumorigenesis 

    AURKB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AURKB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Ubiquitinated Orc1 is degraded by the proteasome
    		Degradation of multiubiquitinated cell cycle proteins0.70
    		Regulation of mitotic cell cycle0.58
    		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.69
    		APC/C-mediated degradation of cell cycle proteins0.58
    3Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    4Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    5Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for AURKB
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Chromosome condensation in prometaphase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AURKB
        Molecular Mechanisms of Cancer
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for AURKB
        Cell Cycle / Checkpoint Control

    3 GeneGo (Thomson Reuters) Pathways for AURKB
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation

    5 BioSystems Pathways for AURKB 
        Aurora C signaling
    FOXM1 transcription factor network
    Aurora A signaling
    Aurora B signaling
    Signaling by Aurora kinases

    5/14        Reactome Pathways for AURKB (see all 14)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Degradation of multiubiquitinated cell cycle proteins
    Mitotic Anaphase



    AURKB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AURKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/890 Interacting proteins for AURKB (Q96GD41, 2, 3 ENSP000003139504) via UniProtKB, MINT, STRING, and/or I2D (see all 890)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=2 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=2 
    HIST1H3CP684313I2D: score=2 
    HIST1H3DP684313I2D: score=2 
    HIST1H3EP684313I2D: score=2 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis ----


    AURKB for ontologies           About GeneDecksing



    Drugs & Compounds
    for AURKB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AURKB for compounds           About GeneDecksing

    EMD Millipore small molecules for AURKB:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for AURKB

    Compounds for AURKB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ZM 447439Inhibits Aurora kinase B[331771-20-1]
    CCT 137690Potent pan-Aurora kinase inhibitor[1095382-05-0]
    Hesperadin hydrochloridePotent Aurora B kinase inhbitor[422513-13-1]

    3 HMDB Compounds for AURKB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for AURKB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HESPERIDIN-- --target--10592235
    N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine-- --target--10592235

    3 Novoseek chemical compound relationships for AURKB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 55.6 9 9931403 (1), 9809983 (1), 11266445 (1), 19287963 (1) (see all 7)
    serine 42.7 5 9931403 (1), 9809983 (1), 19074838 (1), 9606188 (1) (see all 5)
    paclitaxel 10.6 1 19720871 (1)

    Search CenterWatch for drugs/clinical trials and news about AURKB 

    Transcripts
    for AURKB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AURKB gene (2 alternative transcripts): 
    NM_001256834.1  NM_004217.3  

    Unigene Cluster for AURKB:

    Aurora kinase B
    Hs.442658  [show with all ESTs]
    Unigene Representative Sequence: CD049340
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316199(uc021tpy.1 uc010cnu.3 uc002gkm.3 uc002gkn.3 uc010vuu.2 uc002gko.3)
    ENST00000534871 ENST00000585124 ENST00000584972 ENST00000578549 ENST00000580998
    ENST00000578753 ENST00000577833 ENST00000581511 ENST00000580390 ENST00000584561
    ENST00000582368 ENST00000583915 ENST00000583124 ENST00000535053

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate AURKB (see all 11):
    hsa-miR-3173-3p hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-3927
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB011446.1 AB011450.1 AB519677.1 AB519678.1 AB519679.1 AF004022.1 AF008552.1 AF015254.1 
    AK297976.1 AK314889.1 AY677083.1 BC000442.2 BC009751.2 BC013300.2 BC080581.1 BT019534.1 

    19 DOTS entries:

    DT.215614  DT.100037065  DT.308944  DT.100827548  DT.100827551  DT.120919739  DT.97846154  DT.100827558 
    DT.91752525  DT.100827547  DT.100827554  DT.120919755  DT.120919766  DT.40111698  DT.91752526  DT.95189889 
    DT.95354860  DT.99928281  DT.100037064 

    24/274 AceView cDNA sequences (see all 274):

    CR604968 AI803988 BU159806 BC013300 BG470446 BI226599 CB142452 BU153790 
    CR603941 BU173439 BU186069 CR600836 CR591471 BG826770 BU185083 BG117695 
    AL561428 CB143322 BM845066 BU554119 BU157783 BI912762 AY677083 BM910592 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for AURKB (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^
    SP1:                                -     -     -                                         -     -     -                 -     -                                 
    SP2:                                -     -     -                                         -     -     -                 -     -                                 
    SP3:                                -     -     -                       -     -     -     -     -     -                 -     -                                 
    SP4:                                -     -     -                       -     -     -     -     -                       -     -                                 
    SP5:                                -     -     -                       -     -     -     -     -                       -     -                                 

    ExUns: 10a · 10b · 10c · 10d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AURKB

    Expression
    for AURKB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AURKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACAATGAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AURKB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    TestisTestis CordXY Germ CellsGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Adult human kidney epithelial cells (Primary Cell)Kidney

    See AURKB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AURKB

    SOURCE GeneReport for Unigene cluster: Hs.442658

    UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
    Tissue specificity: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon,
    placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M
    phase

        SABiosciences Expression via Pathway-Focused PCR Arrays including AURKB: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
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              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat

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    Orthologs
    for AURKB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AURKB gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 77(a)
    		 1 → many
    		 GL343400.1(503210-507658)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3984572 similar to serine/threonine kinase 12 75.72(n)    AF292096.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii stka2 serine/threonine kinase a 79.44(n)   192306  AY099518.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ial6
    aur6
    		 aurora
    		 41(a)
    40(a)
    		 possible ortholog
    1 ↔ many
    		 2L(10856797-10858094)
    3R(7788852-7790550)
    worm
    (Caenorhabditis elegans)    		 Secernentea air-26
    air-16
    		 Aurora/Ipl1 Related kinase family member (air-1)
    		 54(a)
    44(a)
    		 possible ortholog
    possible ortholog
    		 I(5937479-5938887)
    V(8221390-8223567)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AUR26
    AtAUR16
    (see all 3)    		 serine/threonine-protein kinase aurora-1
    (see all 3)    		 60(a)
    59(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2(11034652-11036910)
    4(15842453-15844536)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 CAMK_CAMK_like_Aur_like.1 - CAMK includes calcium/...
    CAMK_CAMK_like_Aur_like.2 - CAMK includes calcium/...
    		 59(a)
    48(a)
    		 many ↔ many
    many ↔ many
    		 1(4908890-4913370)
    3(31667445-31671597)


    ENSEMBL Gene Tree for AURKB (if available)
    TreeFam Gene Tree for AURKB (if available) 

    Paralogs
    for AURKB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AURKB gene
    AURKA2  AURKC2  
    18/119 SIMAP similar genes for AURKB using alignment to 9 protein entries:     AURKB_HUMAN (see all proteins) (see all similar genes):
    AURKC    AURKA    BRSK2    STK36    MARK2    NUAK1
    PHKG2    PLK1    PLK4    CDK7    MARK4    SIK3
    MARK3    ULK3    RPS6KA3    STK32A    KIAA0999    RPS6KA2

    AURKB for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for AURKB
    PGOHUM00000238927 PGOHUM00000239400 PGOHUM00000249478


    Genomic Variants
    for AURKB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 NCBI SNPs in AURKB are shown (see all 173)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1483646841,2
    		C,other8110550(+) TCCTTA/C/TTCTAT 6 E D syn1 mis10--------
    rs1821549501,2
    		--8107644(+) TCAAAC/GACAGC 2 -- int1 ds50010--------
    rs1419966731,2
    		--8107683(+) CCTACA/GTTGGC 2 -- ds5001 int10--------
    rs1506797111,2
    		--8107717(+) AAAGGA/GAAAAC 2 -- int1 ds50010--------
    rs1862857051,2
    		--8107812(+) CCCAGA/TGCCCC 2 -- ds5001 int10--------
    rs1398742811,2
    		--8107969(+) CATCCC/TGGCTC 2 -- int1 ds50010--------
    rs30272531,2
    		F,H--8107978(+) TCCTCA/TGGGTG 2 -- ds5001 int12Minor allele frequency- T:0.03EA NS 158
    rs75033531,2
    		C,F,A,H,--8107979(+) CCTCAG/TGGTGA 2 -- ds5001 int129Minor allele frequency- N:0.00EA NA NS WA 2984
    rs1498149911,2
    		--8107992(+) CAGCTC/TTCCTT 2 -- int1 ds50010--------
    rs766136361,2
    		C,F,--8108009(+) AACAGC/TTTCCT 2 -- ds5001 int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for AURKB (8108049 - 8113918 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AURKB: --
    Human Gene Mutation Database (HGMD): AURKB

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    Disorders / Diseases
    for AURKB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AURKB for disorders           About GeneDecksing

    OMIM gene information: 604970    OMIM disorders: --

    UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
  • Note=Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity
    • in cancer cells through its dominant-negative effect on cytokinesis

    20/45 diseases for AURKB (see all 45):    About MalaCards
    non-small cell lung carcinoma    non-hodgkin lymphoma    squamous cell carcinoma    giant cell glioblastoma
    laryngeal squamous cell carcinoma    esophageal squamous cell carcinoma    hodgkin's lymphoma    chronic lymphocytic leukemia
    acute myeloid leukemia    epithelial ovarian cancer    lymphocytic leukemia    hepatocellular carcinoma
    myeloid leukemia    carcinoma    lung carcinoma    familial breast cancer
    breast cancer    laryngitis    ovarian cancer    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for AURKB:
    Cancer

    10/12 Novoseek disease relationships for AURKB gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 42.7 8 18767990 (2), 19075809 (1), 17173139 (1), 11005026 (1)
    colorectal tumors 38.8 4 12234980 (2), 9931403 (1), 9809983 (1)
    tumors 29.4 12 9809983 (3), 19188929 (1), 19567821 (1), 12234980 (1) (see all 9)
    carcinoma non-small cell lung 19.8 2 16222316 (1), 17121938 (1)
    retinoblastoma 9.86 1 19225156 (1)
    mesothelioma 7.89 1 17394948 (1)
    hepatocellular carcinoma 2.96 2 17094487 (1), 18311747 (1)
    lung carcinoma 2.82 1 17483322 (1)
    carcinoma squamous cell 0 1 20112500 (1)
    breast cancer 0 2 20175926 (2)

    Human Genome Epidemiology (HuGE) Navigator: AURKB (5 documents)

    Export disorders for AURKB gene to outside databases

    Publications
    for AURKB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AURKB gene, integrated from 9 sources (see all 327):
    (articles sorted by number of sources associating them with AURKB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. (PubMed id 9858806)1, 2, 3, 9 Kimura M.... Okano Y. (1998)
    2. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. (PubMed id 9809983)1, 2, 9 Tatsuka M....Terada Y. (1998)
    3. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PubMed id 17617734)1, 2, 9 Pouwels J.... Kallio M.J. (2007)
    4. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PubMed id 14610074)1, 2, 9 Wheatley S.P.... Earnshaw W.C. (2004)
    5. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. (PubMed id 12925766)1, 2, 9 Honda R....Nigg E.A. (2003)
    6. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)1, 2, 9 Faitar S.L.... Cowell J.K. (2006)
    7. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PubMed id 15249581)1, 2, 9 Gassmann R.... Earnshaw W.C. (2004)
    8. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. (PubMed id 11784863)1, 2, 9 Crosio C.... Sassone-Corsi P. (2002)
    9. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PubMed id 11756469)1, 2, 9 Zeitlin S.G.... Sullivan K.F. (2001)
    10. Aurora B interacts with NIR-p53, leading to p53 phosp horylation in its DNA-binding domain and subsequent functional suppression. (PubMed id 20959462)1, 2 Wu L....Jain A. (2011)

    External Searches for AURKB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AURKB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9212 HGNC: 11390 AceView: AURKB Ensembl:ENSG00000178999 euGenes: HUgn9212
    ECgene: AURKB H-InvDB: AURKB

    Other Databases showing AURKB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AURKB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AURKB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AURKB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AURKB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AURKB gene:
    Search GeneIP for patents involving AURKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
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    von Willebrand factor
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