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Aliases for AURKB Gene

Aliases for AURKB Gene

  • Aurora Kinase B 2 3
  • STK12 3 4 6
  • AIM1 3 4 6
  • AIK2 3 4 6
  • ARK2 3 4 6
  • Serine/Threonine-Protein Kinase Aurora-B 3 4
  • Serine/Threonine-Protein Kinase 12 3 4
  • Serine/Threonine-Protein Kinase 5 3 4
  • Aurora/IPL1-Related Kinase 2 3 4
  • Serine/Threonine Kinase 12 2 3
  • Aurora-Related Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • Aurora-B 2 3
  • Aurora-1 2 3
  • Aurora 1 3 4
  • STK-1 3 4
  • AIM-1 3 4
  • ARK-2 3 4
  • STK5 3 4
  • Aurora- And Ipl1-Like Midbody-Associated Protein 1 3
  • Aurora- And IPL1-Like Midbody-Associated Protein 1 4
  • Protein Phosphatase 1, Regulatory Subunit 48 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 48 2
  • Aurora Kinase B-Sv1 3
  • Aurora Kinase B-Sv2 3
  • Aurkb-Sv1 3
  • Aurkb-Sv2 3
  • EC 2.7.11 63
  • PPP1R48 3
  • AIRK2 4
  • STK1 4
  • AurB 3
  • IPL1 3

External Ids for AURKB Gene

Previous HGNC Symbols for AURKB Gene

  • STK12

Previous GeneCards Identifiers for AURKB Gene

  • GC17M008050
  • GC17M008308
  • GC17M008048
  • GC17M008108
  • GC17M008006

Summaries for AURKB Gene

Entrez Gene Summary for AURKB Gene

  • This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for AURKB Gene

AURKB (Aurora Kinase B) is a Protein Coding gene. Diseases associated with AURKB include neuroblastoma, susceptibility and giant cell glioblastoma. Among its related pathways are ERK Signaling and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is AURKC.

UniProtKB/Swiss-Prot for AURKB Gene

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at Ser-10 and Ser-28 during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.

Tocris Summary for AURKB Gene

  • Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each isoform, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis. Aurora B is the catalytic component of the chromosomal passenger complex (CPC) that is critical for the correct progression through and completion of mitosis. CPC is composed of three other proteins, survivin, INCENP and borealin, which are all substrates for Aurora B and function to regulate the activity of this enzyme. The CPC initially forms along chromosome arms, then concentrates at the centromere before finally localizing to the spindle midzone during cytokinesis. Functions of the CPC include condensation of chromosomes, formation of the bipolar spindle, attachment of the chromosomes to the mitotic spindle, regulation of the spindle checkpoint and completion of cytokinesis. An important target of Aurora B is histone H3, which is a critical regulator of chromosome condensation. H3 phosphorylation is a biomarker of Aurora B activity. Since their discovery in the 1990s, Aurora kinases have been strongly linked to the progression of human cancers. Aurora A maps to human chromosome 20q13 and Aurora B to human chromosome 17q13.1, which are loci altered frequently in human cancers. Overexpression of Aurora A and B is seen in many cancers, but these enzymes are not oncoproteins, as concomitant oncogenic mutations are required to promote tumor progression. Aurora kinase inhibitors are an intense area of research for the development of anticancer therapies.

Gene Wiki entry for AURKB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AURKB Gene

Genomics for AURKB Gene

Regulatory Elements for AURKB Gene

Genomic Location for AURKB Gene

Start:
8,204,731 bp from pter
End:
8,210,626 bp from pter
Size:
5,896 bases
Orientation:
Minus strand

Genomic View for AURKB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AURKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AURKB Gene

Proteins for AURKB Gene

  • Protein details for AURKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GD4-AURKB_HUMAN
    Recommended name:
    Aurora kinase B
    Protein Accession:
    Q96GD4
    Secondary Accessions:
    • B4DNM4
    • C7G533
    • C7G534
    • C7G535
    • D3DTR4
    • J9JID1
    • O14630
    • O60446
    • O95083
    • Q96DV5
    • Q9UQ46

    Protein attributes for AURKB Gene

    Size:
    344 amino acids
    Molecular mass:
    39311 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3, SEPT1, SIRT2 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active, Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28. Interacts with RNF2/RING1B.
    SequenceCaution:
    • Sequence=AAH13300.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AURKB Gene

    Alternative splice isoforms for AURKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AURKB Gene

Proteomics data for AURKB Gene at MOPED

Post-translational modifications for AURKB Gene

  • The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity.
  • Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
  • Ubiquitination at Lys4, Lys31, Lys56, Lys87, Lys164, Lys168, Lys202, Lys211, Lys215, and Lys231
  • Modification sites at PhosphoSitePlus

Domains for AURKB Gene

Gene Families for AURKB Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q96GD4

UniProtKB/Swiss-Prot:

AURKB_HUMAN :
  • Q96GD4
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
genes like me logo Genes that share domains with AURKB: view

Function for AURKB Gene

Molecular function for AURKB Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is greatly increased when AURKB is within the CPC complex. In particular, AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between GSG2 and AURKB contributes to CPC localization.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at Ser-10 and Ser-28 during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
UniProtKB/Swiss-Prot Induction: Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression decreases again after M phase.

Enzyme Numbers (IUBMB) for AURKB Gene

Gene Ontology (GO) - Molecular Function for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 22724069
GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 19774610
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12689593
genes like me logo Genes that share ontologies with AURKB: view
genes like me logo Genes that share phenotypes with AURKB: view

Animal Models for AURKB Gene

MGI Knock Outs for AURKB:

No data available for Transcription Factor Targeting and HOMER Transcription for AURKB Gene

Localization for AURKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for AURKB Gene

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AURKB Gene COMPARTMENTS Subcellular localization image for AURKB gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000779 condensed chromosome, centromeric region IDA 19465021
GO:0000780 condensed nuclear chromosome, centromeric region IDA 18195732
GO:0005634 nucleus IDA 20959462
GO:0005819 spindle TAS 19774610
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AURKB: view

Pathways for AURKB Gene

genes like me logo Genes that share pathways with AURKB: view

Gene Ontology (GO) - Biological Process for AURKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20959462
GO:0000278 mitotic cell cycle TAS --
GO:0002903 negative regulation of B cell apoptotic process IDA 20959462
GO:0006468 protein phosphorylation IDA 21820309
GO:0007067 mitotic nuclear division --
genes like me logo Genes that share ontologies with AURKB: view

Compounds for AURKB Gene

(28) ApexBio Compounds for AURKB Gene

Compound Action Cas Number
AMG-900 potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C [945595-80-2]
Anacardic acid selectively activate Aurora kinase A-mediated phosphorylation of histone H3 [16611-84-0]
AT9283 novel inhibitor of aurora kinase [896466-04-9]
Aurora A Inhibitor I novel, potent, and selective inhibitor of Aurora A [1158838-45-9]
AZD1152 selective Aurora B kinase inhibitor [722543-31-9]
Barasertib (AZD1152-HQPA) potent aurora kinase inhibitor [722544-51-6]
CCT129202 ATP-competitively inhibits Aurora A, Aurora B and Aurora C [942947-93-5]
CCT137690 highly selective inhibitor of Aurora A, Aurora B and Aurora C. [1095382-05-0]
CYC116 potent inhibitor of Aurora A/B. [693228-63-6]
Danusertib (PHA-739358) Pan-aurora kinase inhibitor [827318-97-8]
ENMD-2076 selective activity against Aurora A and VEGFR(Flt3). [934353-76-1]
GSK1070916 reversible and ATP-competitive inhibitor of Aurora B/C. [942918-07-2]
Hesperadin Hesperadin potently inhibits Aurora B with IC50 of 250 nM. [422513-13-1]
JNJ-7706621 dual inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases [443797-96-4]
MK-5108 (VX-689) novel, potent and selective inhibitor of Aurora A kinase. [1010085-13-8]
MK-8745 potent and selective Aurora A inhibitor. [885325-71-3]
MLN8054 potent of Aurora A kinase inhibitor [869363-13-3]
MLN8237 (Alisertib) potent small-molecule inhibitor of Aurora A kinase [1028486-01-2]
PF-03814735 novel, potent and reversible inhibitor of Aurora A/B. [942487-16-3]
PHA-680632 novel and potent inhibitor of Aurora kinases. [398493-79-3]
Reversine inhibition of Aurora A and B. [656820-32-5]
SCH-1473759 novel sub-nanomolar Aurora A/B inhibitor [1094069-99-4]
SNS-314 Mesylate potent and selective inhibitor of Aurora A, Aurora B and Aurora C. [1146618-41-8]
TAK-901 novel inhibitor of Aurora A/B. [934541-31-8]
TC-A 2317 hydrochloride Potent Aurora kinase A inhibitor [1245907-03-2]
VX-680 (MK-0457,Tozasertib) potent inhibitor of pan-aurora kinase [639089-54-6]
XL228 protein kinase inhibitor targeting AURORA kinases [898280-07-4]
ZM 447439 novel, potent and selective inhibitor of Aurora kinase [331771-20-1]

(5) Tocris Compounds for AURKB Gene

Compound Action Cas Number
Anacardic acid Noncompetitive PCAF/p300 HAT inhibitor [16611-84-0]
Hesperadin hydrochloride Potent Aurora kinase B inhibitor [422513-13-1]
PF 03814735 Aurora kinase A and B inhibitor [942487-16-3]
SNS 314 mesylate Potent pan-Aurora kinase inhibitor [1146618-41-8]
TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor [1245907-03-2]

(3) HMDB Compounds for AURKB Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(2) Drugbank Compounds for AURKB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
HESPERIDIN
target
N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine
target

(3) Novoseek inferred chemical compound relationships for AURKB Gene

Compound -log(P) Hits PubMed IDs
threonine 55.6 7
serine 42.7 5
paclitaxel 10.6 1
genes like me logo Genes that share compounds with AURKB: view

Transcripts for AURKB Gene

Unigene Clusters for AURKB Gene

Aurora kinase B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AURKB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - -
SP14: - - -
SP15: - - -
SP16: - - - - - -
SP17: - - - - -
SP18: - - -
SP19:
SP20:

ExUns: 10a · 10b · 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for AURKB Gene

GeneLoc Exon Structure for
AURKB
ECgene alternative splicing isoforms for
AURKB

Expression for AURKB Gene

mRNA expression in normal human tissues for AURKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AURKB Gene

This gene is overexpressed in Nerve - Tibial (4.6) and Esophagus - Mucosa (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AURKB Gene

SOURCE GeneReport for Unigene cluster for AURKB Gene Hs.442658

mRNA Expression by UniProt/SwissProt for AURKB Gene

Q96GD4-AURKB_HUMAN
Tissue specificity: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
genes like me logo Genes that share expressions with AURKB: view

Orthologs for AURKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AURKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AURKB 35
  • 98.84 (n)
  • 98.26 (a)
AURKB 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AURKB 35
  • 90.86 (n)
  • 93.29 (a)
AURKB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AURKB 35
  • 89.99 (n)
  • 91.84 (a)
AURKB 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aurkb 35
  • 83.19 (n)
  • 85.04 (a)
Aurkb 16
Aurkb 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Aurkb 35
  • 84.07 (n)
  • 85.34 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398457 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aurkb 35
  • 66.27 (n)
  • 71.01 (a)
zebrafish
(Danio rerio)
Actinopterygii aurkb 35
  • 69.37 (n)
  • 74.66 (a)
aurkb 36
  • 70 (a)
OneToMany
stka 35
fruit fly
(Drosophila melanogaster)
Insecta aur 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea air-2 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL101C 35
  • 55.08 (n)
  • 46.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPL1 35
  • 50.72 (n)
  • 44.48 (a)
IPL1 36
  • 36 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02332g 35
  • 52.62 (n)
  • 49.43 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9199 35
corn
(Zea mays)
Liliopsida Zm.5439 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00108 35
  • 58.66 (n)
  • 57.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ark1 35
  • 55.94 (n)
  • 63.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4656 36
  • 59 (a)
OneToMany
Species with no ortholog for AURKB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AURKB Gene

ENSEMBL:
Gene Tree for AURKB (if available)
TreeFam:
Gene Tree for AURKB (if available)

Paralogs for AURKB Gene

Paralogs for AURKB Gene

Pseudogenes.org Pseudogenes for AURKB Gene

genes like me logo Genes that share paralogs with AURKB: view

Variants for AURKB Gene

Sequence variations from dbSNP and Humsavar for AURKB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1059456 -- 8,206,843(-) CGGAG(A/G)AGGAT synonymous-codon, reference
rs1059476 - 8,205,013(+) CTCCC(A/G)TGGGC missense, reference
rs1059480 -- 8,204,811(-) GGAAA(A/G)AAGGG utr-variant-3-prime
rs2241909 -- 8,205,021(+) GGCAC(A/G)GAAGC reference, synonymous-codon
rs2289590 -- 8,207,446(+) TCATC(A/C)CATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AURKB Gene

Variant ID Type Subtype PubMed ID
nsv907658 CNV Loss 21882294
nsv833353 CNV Loss 17160897

Relevant External Links for AURKB Gene

HapMap Linkage Disequilibrium report
AURKB
Human Gene Mutation Database (HGMD)
AURKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AURKB Gene

Disorders for AURKB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for AURKB Gene including...

Search for AURKB Gene in MalaCards »

UniProtKB/Swiss-Prot

AURKB_HUMAN
  • Note=Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.

(1) University of Copenhagen DISEASES for AURKB Gene

(12) Novoseek inferred disease relationships for AURKB Gene

Disease -log(P) Hits PubMed IDs
cancer 42.7 5
colorectal tumors 38.8 4
tumors 29.4 11
carcinoma non-small cell lung 19.8 2
retinoblastoma 9.86 1

Relevant External Links for AURKB

Genetic Association Database (GAD)
AURKB
Human Genome Epidemiology (HuGE) Navigator
AURKB
genes like me logo Genes that share disorders with AURKB: view

Publications for AURKB Gene

  1. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. (PMID: 9858806) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PMID: 11756469) Zeitlin S.G. … Sullivan K.F. (J. Cell Biol. 2001) 3 4 23
  3. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. (PMID: 12925766) Honda R. … Nigg E.A. (Mol. Biol. Cell 2003) 3 4 23
  4. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PMID: 14610074) Wheatley S.P. … Earnshaw W.C. (J. Biol. Chem. 2004) 3 4 23
  5. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PMID: 17617734) Pouwels J. … Kallio M.J. (Cell Cycle 2007) 3 4 23

Products for AURKB Gene

  • Addgene plasmids for AURKB

Sources for AURKB Gene

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