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AURKB Gene

protein-coding   GIFtS: 74
GCID: GC17M008108

Aurora Kinase B

(Previous name: serine/threonine kinase 12)
(Previous symbol: STK12)
  See AURKB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aurora Kinase B1 2     STK-12 3
STK121 2 3 5     STK52 3
AIK22 3 5     EC 2.7.11.13 8
AIM12 3 5     Protein Phosphatase 11
ARK22 3 5     Regulatory Subunit 481
Serine/Threonine Kinase 121 2     AurB2
aurora-11 2     IPL12
aurora-B1 2     PPP1R482
Aurora 12 3     aurkb-sv12
Aurora- And IPL1-Like Midbody-Associated Protein 12 3     aurkb-sv22
Aurora-Related Kinase 22 3     Aurora Kinase B-Sv12
Aurora/IPL1-Related Kinase 22 3     Aurora Kinase B-Sv22
Serine/Threonine-Protein Kinase 122 3     Protein Phosphatase 1, Regulatory Subunit 482
Serine/Threonine-Protein Kinase 52 3     AIRK23
Serine/Threonine-Protein Kinase Aurora-B2 3     STK13
AIM-12 3     EC 2.7.118
ARK-22 3     

External Ids:    HGNC: 113901   Entrez Gene: 92122   Ensembl: ENSG000001789997   OMIM: 6049705   UniProtKB: Q96GD43   

Export aliases for AURKB gene to outside databases

Previous GC identifers: GC17M008050 GC17M008308 GC17M008048 GC17M008006


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AURKB Gene:
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the
other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the
regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A
pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jan 2013)

GeneCards Summary for AURKB Gene:
AURKB (aurora kinase B) is a protein-coding gene. Diseases associated with AURKB include neuroblastoma, susceptibility, and polyploidy. GO annotations related to this gene include protein serine/threonine/tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is AURKA.

UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that
acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct
chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle
assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for
the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow
formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP.
Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric
functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and
histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres.
Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is
phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback
between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of
BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activityy. Key regulator of
active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active
promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding
and activity of the USP16 deubiquitinase at transcribed genes

summary for AURKB Gene:
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in
regulating many of the processes that are pivotal to mitosis. Each isoform, Aurora A, Aurora B and Aurora C,
has a different function in the control of mitosis. Aurora B is the catalytic component of the chromosomal
passenger complex (CPC) that is critical for the correct progression through and completion of mitosis. CPC
is composed of three other proteins, survivin, INCENP and borealin, which are all substrates for Aurora B
and function to regulate the activity of this enzyme. The CPC initially forms along chromosome arms, then
concentrates at the centromere before finally localizing to the spindle midzone during cytokinesis.
Functions of the CPC include condensation of chromosomes, formation of the bipolar spindle, attachment of
the chromosomes to the mitotic spindle, regulation of the spindle checkpoint and completion of cytokinesis.
An important target of Aurora B is histone H3, which is a critical regulator of chromosome condensation. H3
phosphorylation is a biomarker of Aurora B activity. Since their discovery in the 1990s, Aurora kinases have
been strongly linked to the progression of human cancers. Aurora A maps to human chromosome 20q13 and Aurora
B to human chromosome 17q13.1, which are loci altered frequently in human cancers. Overexpression of Aurora
A and B is seen in many cancers, but these enzymes are not oncoproteins, as concomitant oncogenic mutations
are required to promote tumor progression. Aurora kinase inhibitors are an intense area of research for the
development of anticancer therapies.

Gene Wiki entry for AURKB (Aurora B kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AURKB gene promoter:
         AREB6   PPAR-gamma1   SREBP-1a   SREBP-1c   Olf-1   PPAR-gamma2   LCR-F1   ITF-2   Tal-1beta   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAURKB promoter sequence
   Search Chromatin IP Primers for AURKB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AURKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

AURKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AURKB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008108:  view genomic region     (about GC identifiers)

Start:
8,108,049 bp from pter      End:
8,113,918 bp from pter
Size:
5,870 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4 (See protein sequence)
Recommended Name: Aurora kinase B  
Size: 344 amino acids; 39311 Da
Cofactor: Magnesium
Subunit: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin,
INCENP, AURKB and AURKC. Associates with RACGAP1 during M phase. Interacts with CDCA1, EVI5, JTB, NDC80, PSMA3,
SEPT1 and TACC1. Interacts with SPDYC; this interaction may be required for proper localization of active,
Thr-232-phosphorylated AURKB form during prometaphase and metaphase. Interacts with p53/TP53. Interacts (via the
middle kinase domain) with NOC2L (via the N- and C-terminus domains). Interacts with TTC28. Interacts with
RNF2/RING1B
Sequence caution: Sequence=AAH13300.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for AURKB:
4AF3 (3D)    
Secondary accessions: B4DNM4 C7G533 C7G534 C7G535 D3DTR4 O14630 O60446 O95083 Q96DV5 Q9UQ46
Alternative splicing: 4 isoforms:  Q96GD4-1   Q96GD4-2   Q96GD4-3   Q96GD4-4   (Not expressed in normal liver, high expression in metastatic liver)

Explore the universe of human proteins at neXtProt for AURKB: NX_Q96GD4

Explore proteomics data for AURKB at MOPED

Post-translational modifications: 

  • The phosphorylation of Thr-232 requires the binding to INCENP and occurs by means of an autophosphorylation
    mechanism. Thr-232 phosphorylation is indispensable for the AURKB kinase activity1
  • Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the
    BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is
    required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex
    from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by
    BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome1
  • Ubiquitination2 at Lys4, Lys31, Lys56, Lys87, Lys164, Lys168, Lys202, Lys211, Lys215, Lys231
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AURKB (Q96GD4) (see all 18)
     TAAPGQK  LYNYFYD  CGTLDYL  EHQLRRE 


    See AURKB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243763.1  NP_001271455.1  NP_004208.2  

    ENSEMBL proteins: 
     ENSP00000313950   ENSP00000443869   ENSP00000463999   ENSP00000462858   ENSP00000462207  
     ENSP00000461981   ENSP00000463636   ENSP00000462930   ENSP00000464031   ENSP00000462027  
     ENSP00000445866  
    Reactome Protein details: Q96GD4

    AURKB Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant AURKB Protein
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    GenScript Custom Purified and Recombinant Proteins Services for AURKB
    Novus Biologicals AURKB Proteins
    Novus Biologicals AURKB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for AURKB
    Cloud-Clone Corp. Proteins for AURKB

     
    Search eBioscience for Proteins for AURKB 

     
    antibodies-online proteins for AURKB (17 products) 

     
    antibodies-online peptides for AURKB

    AURKB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of AURKB
    R&D Systems Antibodies for AURKB (Aurora B)
    Cell Signaling Technology (CST) Antibodies for AURKB  (AurB)
    OriGene Antibodies for AURKB
    OriGene Custom Antibody Services for AURKB
    Novus Biologicals AURKB Antibodies
    Abcam antibodies for AURKB
    Cloud-Clone Corp. Antibodies for AURKB
    ThermoFisher Antibody for AURKB
    antibodies-online antibodies for AURKB (164 products) 

    AURKB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for AURKB
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    Search eBioscience for ELISAs for AURKB 
    antibodies-online kits for AURKB (15 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    IUPHAR Guide to PHARMACOLOGY protein family classification: aurora kinase B
    Aurora kinase (Aur) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR028772 AURKB
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q96GD4

    ProtoNet protein and cluster: Q96GD4

    UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with AURKB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AURKB_HUMAN, Q96GD4
    Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that
    acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct
    chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle
    assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for
    the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow
    formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP.
    Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric
    functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and
    histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres.
    Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is
    phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback
    between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of
    BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activityy. Key regulator of
    active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active
    promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding
    and activity of the USP16 deubiquitinase at transcribed genes
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activity is greatly increased when AURKB is within the CPC complex. In particular,
    AURKB-phosphorylated INCENP acts as an activator of AURKB. Positive feedback between GSG2 and AURKB contributes
    to CPC localization
    Induction: Expression is cell cycle-regulated, with a low in G1/S, an increase during G2 and M. Expression
    decreases again after M phase

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19774610
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12689593
         
    Find genes that share ontologies with AURKB           About GenesLikeMe


    Phenotypes:
         11 GenomeRNAi human phenotypes for AURKB:
     Cell division defect  Decreased cell number, increas  Decreased substrate adherent c  Decreased telomerase activity 
     Decreased viability  Decreased viability of wild-ty  Increased ID2::GFP protein exp  Increased cell death in breast 
     Increased cell number in G2M,   Paclitaxel antagonistic effect  Wnt reporter downregulated 

         10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Aurkb):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  no phenotypic analysis  reproductive system  tumorigenesis 

    Find genes that share phenotypes with AURKB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aurkbtm1.2Mama for AURKB

       genOway: Develop your customized and physiologically relevant rodent model for AURKB

    miRNA
    Products:
        
    miRTarBase miRNAs that target AURKB:
    hsa-mir-148a-3p (MIRT048044), hsa-mir-155-5p (MIRT020616), hsa-mir-124-3p (MIRT022319), hsa-mir-92a-3p (MIRT049133), hsa-mir-24-3p (MIRT000120), hsa-mir-125b-5p (MIRT046053), hsa-mir-16-5p (MIRT004742), hsa-let-7b-5p (MIRT001649)

    Block miRNA regulation of human, mouse, rat AURKB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AURKB (see all 11):
    hsa-miR-3173-3p hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-3927
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AURKB

    Gene Editing
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    Sino Biological Human cDNA Clone for AURKB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AURKB
    Addgene plasmids for AURKB 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AURKB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AURKB_HUMAN, Q96GD4: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.
    Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to
    the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the
    mid-body. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon
    interaction with SPDYC
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000779condensed chromosome, centromeric region IDA19465021
    GO:0000780condensed nuclear chromosome, centromeric region IDA18195732
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005819spindle TAS19774610

    Find genes that share ontologies with AURKB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AURKB About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G10.93
    Regulation of mitotic cell cycle0.94
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Aurora B signaling
    Aurora B signaling
    Signaling by Aurora kinases0.00
    Aurora C signaling0.00
    5Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with AURKB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for AURKB
        Molecular Mechanisms of Cancer
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for AURKB
        Cell Cycle / Checkpoint Control

    3 GeneGo (Thomson Reuters) Pathways for AURKB
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation

    Selected BioSystems Pathways for AURKB (see all 6)
        Aurora A signaling
    FOXM1 transcription factor network
    Aurora C signaling
    Aurora B signaling
    Regulation of Microtubule Cytoskeleton


    4 Reactome Pathways for AURKB
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


        Pathway & Disease-focused RT2 Profiler PCR Arrays including AURKB: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for AURKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AURKB (Q96GD41, 2, 3 ENSP000003139504) via UniProtKB, MINT, STRING, and/or I2D (see all 1030)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=2 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=2 
    HIST1H3CP684313I2D: score=2 
    HIST1H3DP684313I2D: score=2 
    HIST1H3EP684313I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis ----
    GO:0002903negative regulation of B cell apoptotic process IDA--
    GO:0006468protein phosphorylation IDA--

    Find genes that share ontologies with AURKB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for AURKB
    Selected ApexBio Compounds for AURKB (see all 28)     About this table
    CompoundAction CAS #
    AMG-900potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C[945595-80-2]
    Anacardic acidselectively activate Aurora kinase A-mediated phosphorylation of histone H3[16611-84-0]
    AT9283novel inhibitor of aurora kinase[896466-04-9]
    Aurora A Inhibitor Inovel, potent, and selective inhibitor of Aurora A[1158838-45-9]
    AZD1152selective Aurora B kinase inhibitor[722543-31-9]
    Barasertib (AZD1152-HQPA)potent aurora kinase inhibitor[722544-51-6]
    CCT129202ATP-competitively inhibits Aurora A, Aurora B and Aurora C[942947-93-5]
    CCT137690highly selective inhibitor of Aurora A, Aurora B and Aurora C[1095382-05-0]
    CYC116potent inhibitor of Aurora A/B[693228-63-6]
    Danusertib (PHA-739358)potent small-molecule inhibitor of aurora B kinase[827318-97-8]

    Compounds for AURKB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Anacardic acidNoncompetitive PCAF/p300 HAT inhibitor[16611-84-0]
    SNS 314 mesylatePotent pan-Aurora kinase inhibitor[1146618-41-8]
    TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor [1245907-03-2]
    CCT 137690Potent pan-Aurora kinase inhibitor[1095382-05-0]
    Hesperadin hydrochloridePotent Aurora kinase B inhibitor[422513-13-1]

    3 HMDB Compounds for AURKB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for AURKB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HESPERIDIN-- --target--10592235
    N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine-- --target--10592235

    3 Novoseek inferred chemical compound relationships for AURKB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 55.6 9 9931403 (1), 9809983 (1), 11266445 (1), 19287963 (1) (see all 7)
    serine 42.7 5 9931403 (1), 9809983 (1), 19074838 (1), 9606188 (1) (see all 5)
    paclitaxel 10.6 1 19720871 (1)



    Find genes that share compounds with AURKB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for AURKB gene (3 alternative transcripts): 
    NM_001256834.1  NM_001284526.1  NM_004217.3  

    Unigene Cluster for AURKB:

    Aurora kinase B
    Hs.442658  [show with all ESTs]
    Unigene Representative Sequence: CD049340
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316199(uc021tpy.1 uc010cnu.3 uc002gkm.3 uc002gkn.3 uc010vuu.2 uc002gko.3)
    ENST00000534871 ENST00000585124 ENST00000584972 ENST00000578549 ENST00000580998
    ENST00000578753 ENST00000577833 ENST00000581511 ENST00000580390 ENST00000584561
    ENST00000582368 ENST00000583915 ENST00000583124 ENST00000535053
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AURKB (see all 11):
    hsa-miR-3173-3p hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-3927
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      QuantiFast Probe-based Assays in human, mouse, rat AURKB

    Additional mRNA sequence: 

    AB011446.1 AB011450.1 AB519677.1 AB519678.1 AB519679.1 AF004022.1 AF008552.1 AF015254.1 
    AK297976.1 AK314889.1 AY677083.1 BC000442.2 BC009751.2 BC013300.2 BC080581.1 BT019534.1 

    19 DOTS entries:

    DT.215614  DT.100037065  DT.308944  DT.100827548  DT.100827551  DT.120919739  DT.97846154  DT.100827558 
    DT.91752525  DT.100827547  DT.100827554  DT.120919755  DT.120919766  DT.40111698  DT.91752526  DT.95189889 
    DT.95354860  DT.99928281  DT.100037064 

    Selected AceView cDNA sequences (see all 274):

    CR591471 BX463217 BQ056188 BM910592 BG470446 BU848701 BQ054552 BU162471 
    BG117695 CA488263 BU185083 AI352050 CR617702 H81024 CB137591 BC009751 
    BI912762 BU902604 BG826770 BM788554 BC013300 CR600836 BU173439 BM849844 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AURKB (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^
    SP1:                                -     -     -                                         -     -     -                 -     -                                 
    SP2:                                -     -     -                                         -     -     -                 -     -                                 
    SP3:                                -     -     -                       -     -     -     -     -     -                 -     -                                 
    SP4:                                -     -     -                       -     -     -     -     -                       -     -                                 
    SP5:                                -     -     -                       -     -     -     -     -                       -     -                                 

    ExUns: 10a · 10b · 10c · 10d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for AURKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    AURKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAATGAGA
    AURKB Expression
    About this image


    AURKB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad
             XY Germ Cells Testis Cord
    AURKB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AURKB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442658

    UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
    Tissue specificity: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis,
    colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells
    during M phase

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AURKB: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AURKB gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aurkb1 , 5 aurora kinase B1, 5 83.19(n)1
    85.04(a)1
      11 (42.32 cM)5
    208771  NM_011496.11  NP_035626.11 
     690456475 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    66(a)
    1 → many
    GL343400.1(501601-511324)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984572 similar to serine/threonine kinase 12 75.72(n)    AF292096.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stka2 serine/threonine kinase a 79.44(n)   192306  AY099518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aur6
    aurora
    42(a)
    1 → many
    3R(7788852-7790550)
    worm
    (Caenorhabditis elegans)
    Secernentea air-26
    Protein AIR-2 (air-2) mRNA, complete cds
    55(a)
    1 → many
    I(5937477-5938885) WBGene00000099
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IPL11 IPL1 50.72(n)
    44.48(a)
      855892   NP_015115.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.91992 Transcribed sequence with moderate similarity to protein more 73.32(n)    BU987283.1 


    ENSEMBL Gene Tree for AURKB (if available)
    TreeFam Gene Tree for AURKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AURKB gene
    AURKA2  STK362  AURKC2  
    Selected SIMAP similar genes for AURKB using alignment to 8 protein entries:     AURKB_HUMAN (see all proteins) (see all similar genes):
    AURKA    AURKC    BRSK2    STK36    MARK2    NUAK1
    PHKG2    PLK1    PLK4    CDK7    MARK4    MARK3
    SIK3    ULK3    RPS6KA3    KIAA0999    STK32A    BRSK1

    Find genes that share paralogs with AURKB           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for AURKB
    PGOHUM00000238927 PGOHUM00000239400 PGOHUM00000249478


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for AURKB (see all 244)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483646841,2
    Cuntested18110550(+) TCCTTA/C/TTCTAT 4 E syn10--------
    rs1821549501,2
    --8107644(+) TCAAAC/GACAGC 2 -- ds5001 int10--------
    rs1419966731,2
    --8107683(+) CCTACA/GTTGGC 2 -- ds5001 int10--------
    rs1506797111,2
    --8107717(+) AAAGGA/GAAAAC 2 -- ds5001 int10--------
    rs1862857051,2
    --8107812(+) CCCAGA/TGCCCC 2 -- ds5001 int10--------
    rs3712443701,2
    C--8107936(+) GTAGGA/GGTTAC 2 -- ds5001 int10--------
    rs1398742811,2
    C--8107969(+) CATCCC/TGGCTC 2 -- ds5001 int10--------
    rs30272531,2
    F,H--8107978(+) TCCTCA/TGGGTG 2 -- ds5001 int12Minor allele frequency- T:0.03EA NS 158
    rs75033531,2
    C,F,A,H--8107979(+) CCTCAG/TGGTGA 2 -- ds5001 int129Minor allele frequency- N:0.00EA NA NS WA 2984
    rs1498149911,2
    --8107992(+) CAGCTC/TTCCTT 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for AURKB (8108049 - 8113918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AURKB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833353CNV Loss17160897
    nsv907658CNV Loss21882294

    Human Gene Mutation Database (HGMD): AURKB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AURKB
    DNA2.0 Custom Variant and Variant Library Synthesis for AURKB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604970    OMIM disorders: --

    UniProtKB/Swiss-Prot: AURKB_HUMAN, Q96GD4
  • Note=Disruptive regulation of expression is a possible mechanism of the perturbation of chromosomal
    integrity in cancer cells through its dominant-negative effect on cytokinesis

  • 3 diseases for AURKB:    
    About MalaCards
    neuroblastoma, susceptibility    polyploidy    giant cell glioblastoma

    1 disease from the University of Copenhagen DISEASES database for AURKB:
    Cancer

    Find genes that share disorders with AURKB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for AURKB gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 42.7 8 18767990 (2), 19075809 (1), 17173139 (1), 11005026 (1)
    colorectal tumors 38.8 4 12234980 (2), 9931403 (1), 9809983 (1)
    tumors 29.4 12 9809983 (3), 19188929 (1), 19567821 (1), 12234980 (1) (see all 9)
    carcinoma non-small cell lung 19.8 2 16222316 (1), 17121938 (1)
    retinoblastoma 9.86 1 19225156 (1)
    mesothelioma 7.89 1 17394948 (1)
    hepatocellular carcinoma 2.96 2 17094487 (1), 18311747 (1)
    lung carcinoma 2.82 1 17483322 (1)
    carcinoma squamous cell 0 1 20112500 (1)
    breast cancer 0 2 20175926 (2)

    Genetic Association Database (GAD): AURKB
    Human Genome Epidemiology (HuGE) Navigator: AURKB (5 documents)

    Export disorders for AURKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for AURKB gene, integrated from 10 sources (see all 368):
    (articles sorted by number of sources associating them with AURKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. (PubMed id 9858806)1, 2, 3, 9 Kimura M.... Okano Y. (Cytogenet. Cell Genet. 1998)
    2. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. (PubMed id 9809983)1, 2, 9 Tatsuka M....Terada Y. (Cancer Res. 1998)
    3. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PubMed id 17617734)1, 2, 9 Pouwels J.... Kallio M.J. (Cell Cycle 2007)
    4. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PubMed id 14610074)1, 2, 9 Wheatley S.P.... Earnshaw W.C. (J. Biol. Chem. 2004)
    5. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. (PubMed id 12925766)1, 2, 9 Honda R.... Nigg E.A. (Mol. Biol. Cell 2003)
    6. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)1, 2, 9 Faitar S.L.... Cowell J.K. (Exp. Cell Res. 2006)
    7. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PubMed id 15249581)1, 2, 9 Gassmann R.... Earnshaw W.C. (J. Cell Biol. 2004)
    8. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. (PubMed id 11784863)1, 2, 9 Crosio C.... Sassone-Corsi P. (Mol. Cell. Biol. 2002)
    9. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PubMed id 11756469)1, 2, 9 Zeitlin S.G.... Sullivan K.F. (J. Cell Biol. 2001)
    10. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. (PubMed id 20959462)1, 2 Wu L.... Jain A. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9212 HGNC: 11390 AceView: AURKB Ensembl:ENSG00000178999 euGenes: HUgn9212
    ECgene: AURKB H-InvDB: AURKB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AURKB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AURKB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AURKB gene:
    Search GeneIP for patents involving AURKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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